CN113456290B

CN113456290B - Degradable metal skull repairing mesh implant

Info

Publication number: CN113456290B
Application number: CN202110706037.6A
Authority: CN
Inventors: 王鲁宁; 姚生莲; 唐蕴知; 邬军
Original assignee: University of Science and Technology Beijing USTB
Current assignee: University of Science and Technology Beijing USTB
Priority date: 2021-06-24
Filing date: 2021-06-24
Publication date: 2022-11-04
Anticipated expiration: 2041-06-24
Also published as: CN113456290A

Abstract

The invention provides a degradable metal skull repairing mesh implant, which comprises: the bridge wire structure is used for realizing in-plane stretching or compression deformation under the action of stress; the island-shaped structure is used for realizing out-of-plane deformation in the direction perpendicular to the mesh-shaped implant so as to form a net bag structure; after being connected with each other, the bridge wire structures are wound around the periphery of the island-shaped structures and connected with the island-shaped structures to form a net-shaped support; the invention can adapt to intracranial pressure change after implantation, generate self-adaptive deformation in the development process of children, continuously provide stable mechanical support, avoid untight adhesion and displacement with the skull, and solve the problems of poor adaptability and the like of the conventional skull repairing device; the problem that the mechanical supporting effect on an implanted area is lost due to structural damage or the degradable stent falls off in a large area in the degradation process can be avoided before the degradable stent is completely degraded.

Description

Degradable metal skull repairing mesh implant

[ technical field ] A method for producing a semiconductor device

The invention relates to the technical field of skull repair, in particular to a degradable metal skull repair mesh implant.

[ background of the invention ]

Cranial defects exist in a variety of clinical situations such as trauma, developmental malformations, tumor resection, and the like. The number of skull defects caused by craniocerebral trauma is as high as 100-200/10 ten thousand, and the mortality rate and the disability rate are the first of all types of trauma. The patient is faced with not only deformity in appearance but also psychological anxiety and fear. The restoration of the mechanical integrity of the skeleton is of great importance for the psychological and physiological rehabilitation of the patient. The currently used skull repairing materials mainly include two main types, namely natural biological materials and artificial synthetic materials. The natural biological material is derived from autogenous bone, allogeneic bone and xenogeneic bone, and is only used for the filling type transplantation of small-area skull defect due to the defects of limited material selection, immunological rejection reaction, infection risk and the like.

Therefore, the inert metal titanium and the alloy thereof are mainly used as the support material of the skull repairing net for clinically repairing skull defects at present, and the material serving as the most common metal material of the orthopedic implant has the characteristics of good biocompatibility and higher mechanical property. In recent years, a polyetheretherketone and reinforced composite (PEEK) skull repairing scaffold prepared by adopting a 3D printing mode aiming at a region with a complex structure are also clinically developed, and compared with titanium and titanium alloy, the material has lower density, does not influence development detection and has higher mechanical supporting capacity.

However, the main skull repairing scaffold materials are all non-degradable, although the skull defect is difficult to regenerate due to the large damage area, the non-degradable scaffold always has the risks of causing pain and infection in the damaged area and occupies the damaged area to influence the skull repairing regeneration. In order to promote the skull to be repaired and regenerated, some research teams develop a high-molecular skull repair scaffold at present, but the high-molecular skull repair scaffold has weak mechanical supporting capability and limited promotion effect on the skull regeneration. The degradable metal stent not only has excellent mechanical property and provides a good mechanical supporting effect for skull coloboma, but also has the effect of promoting osteogenesis or resisting bacteria by ions generated by degradation. Therefore, the degradable metal stent has great application and development prospects in the repair and treatment of skull defects. Particularly, aiming at the skull defects of children in the development stage, the advantages of the degradable metal stent can be reflected by the good mechanical supporting effect and the degradable property of the degradable metal stent.

Accordingly, there is a need to develop a degradable metal cranial prosthetic mesh implant that addresses the deficiencies of the prior art to solve or alleviate one or more of the problems set forth above.

[ summary of the invention ]

In view of this, the invention provides a degradable metal skull repair mesh implant aiming at skull defects, in particular to the skull defect situation of children with large skull deformation after implantation, which can adapt to the intracranial pressure change after implantation, generate self-adaptive deformation in the child development process, continuously provide stable mechanical support, avoid the untight adhesion and displacement with the skull, and solve the problems of poor adaptability and the like of the conventional skull repair device; different from a clinically used non-degradable stent, the stress of the degradable stent in the deformation process promotes the degradation speed and the maintenance problem of the mesh stent, and the problem that the mechanical support effect on an implanted region is lost due to the structural damage or the large-area falling-off occurs in the degradation process before the degradable stent is completely degraded is ensured.

In one aspect, the present invention provides a degradable metal skull repairing mesh implant, the mesh implant comprising:

the bridge wire structure is used for realizing in-plane stretching or compression deformation under the action of stress;

the island-shaped structure is used for realizing out-of-plane deformation in the direction perpendicular to the mesh-shaped implant so as to form a net bag structure;

after being connected with each other, the bridge wire structures are wound around the periphery of the island-shaped structures and connected with the island-shaped structures to form a net-shaped support;

a plurality of mesh stents are interconnected to form a mesh implant.

The above aspects and any possible implementation manners further provide an implementation manner, where the bridgewire structure includes a bridgewire arc unit, a bridgewire parallel unit, and two bridgewire node units, where the two bridgewire node units are respectively disposed at two ends of the bridgewire arc unit, and two ends of the bridgewire parallel unit are connected to the bridgewire arc unit.

The above aspects and any possible implementation manners further provide an implementation manner that the number of the bridge line arc units and the bridge line juxtaposition units is not less than one, the bridge line arc units include but are not limited to S-shaped and wave-shaped, and the bridge line juxtaposition units are circular arc lines.

The above aspect and any possible implementation manner further provide an implementation manner, where the island-shaped structure includes at least six island-shaped arc line units, the island-shaped arc line units include an extending portion, and a connecting portion, the extending portion includes a plurality of extending arcs arranged in parallel, both ends of each extending arc are connected to the extending portion, and the extending portion is connected to the bridge line node unit through the connecting portion.

The above aspects and any possible implementations further provide an implementation manner, wherein the shape of the extending portion includes, but is not limited to, an S shape, the connecting portion is a circular arc line, the extending portion is used for realizing in-plane deformation parallel to the direction of the mesh stent, and the connecting portion is used for realizing out-of-plane deformation perpendicular to the direction of the mesh stent.

The above aspect and any possible implementation manner further provide an implementation manner, wherein the inside of the island-shaped structure is hollow, and the hollow part is used for bearing a medicine.

The above aspects and any possible implementation further provide an implementation manner that the mesh stent is formed by performing finite element mechanical simulation analysis, and adopting a thickened design manner for a structural region with stress concentration in an implantation environment, so as to increase the width of a connection of the region, wherein the structural region with stress concentration comprises a bridgewire arc unit, a bridgewire parallel unit and a bridgewire node unit.

The above aspect and any possible implementation manner further provide an implementation manner, wherein the mesh implant further comprises an edge support, the edge support is arranged outside the mesh support, the edge support is connected with the mesh support, the edge support is provided with nail holes, and the nail holes are connected with the bridgewire node units.

The above aspects and any possible implementations further provide an implementation where the mesh stent is made of a material including, but not limited to, zinc alloy, magnesium alloy, and iron alloy.

The above aspect and any possible implementation further provide an implementation that, in a specific application, the mesh-shaped scaffold is a curved structure when fitting to the shape of the skull, and when repairing skull injury, the mesh-shaped scaffold is a planar structure and is adjusted to a shape fitting to the skull.

Compared with the prior art, the invention can obtain the following technical effects:

1): the skull restoration net provided by the invention can be more firmly contacted and fixed with the skull of a human body, so that the displacement of the skull restoration net can be reduced, and the secondary injury to the head of a patient is avoided;

2): the skull restoration net can be properly bent and twisted to deform, so that the skull restoration net is more easily attached to the appearance of the skull, a better fixing effect is achieved, and a series of health problems caused by skull restoration through a conventional mesh scaffold are prevented;

3): particularly for children patients, the skull repairing device can expand and deform a certain amount along with the development of bones along with the development of the skull of the patient after an operation, so that good structural adaptability and a protection effect are achieved, the clinical problem of skull repair of children is solved, and the risk of repairing the skull for many times in the growth process of infants is avoided;

4): the children patient is in a development stage, the skull defect can be restored by the human body to form bone, the biodegradable metal material is selected to provide enough mechanical support in the initial stage of implantation, and the bone is gradually degraded along with the development and the bone healing of the children patient, so that the medical cost is greatly saved.

Of course, it is not necessary for any one product in which the invention is practiced to achieve all of the above-described technical effects simultaneously.

[ description of the drawings ]

In order to more clearly illustrate the technical solutions of the embodiments of the present invention, the drawings required to be used in the embodiments will be briefly described below, and it is obvious that the drawings in the following description are only some embodiments of the present invention, and it is obvious for those skilled in the art that other drawings can be obtained according to the drawings without creative efforts.

FIG. 1 is a schematic view of the overall structure of a degradable metal skull repairing mesh implant provided by an embodiment of the invention;

FIG. 2 is a block diagram of a bridgewire provided in accordance with one embodiment of the present invention;

FIG. 3 is a schematic view of an island structure provided by an embodiment of the present invention;

FIG. 4 is a pictorial view of a mesh implant provided in accordance with one embodiment of the present invention;

fig. 5 is a diagram of a mesh implant pre-deformed object according to an embodiment of the present invention.

[ detailed description ] embodiments

In order to better understand the technical scheme of the invention, the following detailed description of the embodiments of the invention is made with reference to the accompanying drawings.

It should be understood that the described embodiments are only some embodiments of the invention, and not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

The terminology used in the embodiments of the invention is for the purpose of describing particular embodiments only and is not intended to be limiting of the invention. As used in the examples of the present invention and the appended claims, the singular forms "a," "an," and "the" are intended to include the plural forms as well, unless the context clearly indicates otherwise.

In one aspect, the present invention provides a degradable metal skull repairing mesh implant, comprising:

a plurality of mesh stents are interconnected to form a mesh implant.

The bridge wire structure comprises bridge wire arc-shaped units, bridge wire parallel units and two bridge wire node units, wherein the two bridge wire node units are arranged at two ends of each bridge wire arc-shaped unit respectively, and two ends of each bridge wire parallel unit are connected to the bridge wire arc-shaped units. The bridge wire arc-shaped unit and the bridge wire parallel unit are not less than one, the bridge wire arc-shaped unit comprises but not limited to S shape and wave shape, and the bridge wire parallel unit is in a circular arc shape.

Island structure includes six at least island pitch arc units, island pitch arc unit is including extension portion, extension and connecting portion, extension portion includes a plurality of parallel arrangement extension arcs, and every extension arc both ends all are connected with the extension, the extension passes through connecting portion connection bridgewire node unit. The shape of the extending part comprises but is not limited to S shape, the connecting part is a circular arc line, the extending part is used for realizing in-plane deformation parallel to the direction of the reticular stent, and the connecting part is used for realizing out-plane deformation perpendicular to the direction of the reticular stent.

The island-shaped structure is hollow inside, and the hollow part is used for bearing the medicine. The net-shaped support adopts a thickening design mode for a structural area with stress concentration in an implantation environment through finite element mechanical simulation analysis, and the width of the connection of the area is increased, wherein the structural area with the stress concentration comprises a bridge wire arc-shaped unit, a bridge wire parallel unit and a bridge wire node unit.

The net-shaped implant further comprises an edge support, the edge support is arranged on the outer side of the net-shaped support, the edge support is connected with the net-shaped support, nail holes are formed in the edge support, and the nail holes are connected with the bridge line node units.

The mesh scaffold is made of materials including but not limited to zinc alloy, magnesium alloy and iron alloy. When the net-shaped bracket is applied specifically, the net-shaped bracket is of a curved surface structure when being matched with the shape of a skull, and is of a plane structure when being used for repairing skull injuries, and the net-shaped bracket is adjusted to be matched with the skull.

The design principle of the invention is as follows:

the island-bridge structure is designed in such a way that one island-shaped structure is connected with other island-shaped structures after being connected by a plurality of bridge wire structures, the bridge wire structures and the island-shaped structures are regularly and alternately distributed, the bridge wire structures are used as first-stage main structures of the net-shaped support, and the island-shaped structures are used as secondary structures. Island constitutional unit's design is the pitch arc design of inside fretwork, and island structure can realize warping at the off-plane of perpendicular to net shape support direction to form similar string bag structure, not only can regard as the carrier of medicine, still can provide the space for the whole deformation of support. The bridge wire structure is an arc bending structure, and can realize the deformation of stretching or compression under the action of in-plane stress. By carrying out finite element mechanical analysis on the reticular stent, a thickening design mode is adopted for a structural region with stress concentration in an implantation environment, namely the width of the connection of the region is increased; the design of parallel arc line structures is added for the area with larger stress concentration, so that after the original bearing structure is deformed or degraded, the parallel structures can be further used as a deformation expanding structure and a reticular support maintaining structure. The skull repairing mesh scaffold can be bent and twisted to deform properly, so that the skull repairing mesh scaffold is attached to the appearance of the skull more easily, can be contacted and fixed with the skull of a human body more firmly, and prevents a series of health problems caused by repairing the skull by using the conventional mesh scaffold. Particularly for children patients, after operation, the skull repairing device can expand and deform a certain amount along with the development of bones along with the development of the skull of the children, so that good structural adaptability and a protection effect are achieved, the clinical problem of skull repair of the children is solved, and the risk of repairing the skull for many times in the growth process of the children is avoided.

The specific implementation mode of the invention is as follows:

1. in the design of the mesh-shaped support, the characteristic of the mesh-shaped support which is adaptive to skull deformation is firstly considered, and adaptive deformation can be realized in the stress environment of skull growth, namely, the mesh-shaped support can generate large-size compression or stretching action according to factors such as skull growth, and the strain size range can be more than 5%. The specific implementation mode is the design of an island bridge structure:

1-1, the island-shaped structure units are designed into arc lines with hollow interiors, and the island-shaped structures can deform outside the surface perpendicular to the direction of the net-shaped support, so that a similar net bag structure is formed, the island-shaped structure not only can be used as a carrier of a medicament, but also can provide space for the overall deformation of the support, and has a good buffering effect on out-of-surface impact;

1-2, designing an in-plane deformable curve structure inside the island-shaped structure, wherein the island-shaped structure is provided with an out-of-plane deformation arc line design of 1-1 and an in-plane large-angle arc line design to increase the deformation degree of the island-shaped structure, and simultaneously plays roles in deformation buffering and protection on the out-of-plane deformation arc line design of the island-shaped structure;

the 1-3 bridge line structure is an arc line bending structure, and can realize large deformation of in-plane stretching or compression under the action of stress;

1-4, connecting one island-shaped structure with other island-shaped structures after a plurality of bridge line structures are connected, wherein the bridge line structures and the island-shaped structures are regularly and alternately distributed, the bridge line structures are used as a first-stage main structure of the net-shaped support, and the island-shaped structures are used as a secondary structure;

2. on the basis of fully considering the deformation of the reticular stent, the degradable metal skull repairing net also needs to mainly consider the problem that the degradation speeds of different regions of the reticular stent are inconsistent after deformation occurs under the stress condition along with the lapse of implantation time. In order to ensure the maintenance of the mesh stent under the stress degradation condition and avoid the problem of the whole block falling off. The invention mainly adopts a primary and secondary structure design:

2-1, performing finite element mechanical simulation analysis on the reticular stent, and adopting a thickening design mode for a structural region with stress concentration in an implantation environment, namely increasing the connection width of the region;

2-2, parallel arc line structure design is added for the area with larger stress concentration, so that after the original bearing structure is deformed or degraded, the parallel structure can be further used as a deformation expanding structure and a reticular support maintaining structure.

3. In order to ensure the supporting function of the reticular stent under the stress condition, the area of the stent occupies 30-50% of the area of the whole region before deformation, so that the uniform reticular stent can still be ensured after the stent is in a stretching state under a larger stress condition.

4. In order to ensure the implantation effect and good fit degree with the skull, the degradable metal skull scaffold adopts a predeformation design. Compared with other bone tissues, different areas of the skull have different structural characteristics and obvious individual difference, so that a pure metal mesh patch is usually reshaped in the operation and cannot be well matched with an implanted area in shape. Therefore, the degradable metal skull restoration net provided by the invention is pre-deformed according to the CT scanning result of the damaged area before implantation, so that the shape of the damaged area of the skull can be better met.

5. Threaded holes fixed with the skull are designed at the edge of the degradable metal skull restoration net at equal intervals so as to meet the fixing requirement of the mesh-shaped bracket and the skull.

Example 1

In the design of the mesh-shaped support, the characteristic of the mesh-shaped support which is adaptive to skull deformation is firstly considered, and adaptive deformation can be realized in the stress environment of skull growth, namely, the mesh-shaped support can generate large-size compression and stretching actions according to factors such as skull growth, and the strain size range can be more than 5%. The specific implementation mode is the design of an island bridge structure. The net-shaped stent 200 shown in fig. 1 is composed of the bridgewire structures 110 and the island-shaped structures 120 which are regularly and alternately distributed. On the basis of fully considering the deformation of the net-shaped bracket, the degradable metal skull repairing net also needs to mainly consider the problem that the degradation speeds of different areas of the net-shaped bracket are inconsistent after the net-shaped bracket deforms under the stress condition along with the lapse of implantation time. In order to ensure the maintenance of the mesh stent under the stress degradation condition and avoid the problem of the whole piece falling off. The invention mainly adopts a primary and secondary structure design. One island-shaped structure 120 is connected with other island-shaped structures after being connected by a plurality of bridge wire structures 110, the bridge wire structures 110 are used as a first-stage main structure of the net-shaped support, and the island-shaped structures 120 are used as secondary structures. The mesh stent 200 requires a certain thickness in order to achieve a certain radial support strength. The thickness of the mesh-like stent 200 is generally 0.2mm to 1mm. The mesh support 200 may be a curved structure that conforms to the shape of the skull. The mesh support 200 may also be a planar structure that adjusts to a shape that fits the skull when repairing the skull injury.

Island bridge structure 100 main part is an island structure 120, island structure 120's design is the pitch arc design of inside fretwork, island structure 120 can realize warping at the off-plane of perpendicular to net support direction, thereby form similar string bag structure, not only can regard as the carrier of medicine, still can provide the space for the whole deformation of support, island bridge structure 100a and island bridge structure 100 b's main part is two island structures separately in figure 1, island structure periphery centers on through the bridgewire structure, and two island structures have public bridgewire structure. Specifically, as shown in fig. 3, the island structures 120 include at least six arc-shaped units. In the present embodiment, the island-shaped structure 120 includes an S-shaped extending portion 121, and both ends of the extending portion 121 are connected by a connecting portion 122. The extensions 121 are intended to achieve in-plane deformation parallel to the direction of the mesh stent. The circular arc line 123 can realize out-of-plane deformation in a direction perpendicular to the mesh stent, thereby forming a string bag-like structure. The extension 121 and the arc line 123 may have other curvatures. Optionally, the island-like structures 120 have a cross-sectional width of 0.4mm to 1mm. The cross-sectional width of the island structures 120 affects the deformability of the island structures 110. It should be noted that, as technology develops and new materials emerge, the cross-sectional width of the island-shaped structures 110 can be adjusted, which is not absolute. Preferably, the island-like structures 110 have a cross-sectional width of 0.5mm. The island-like structures 110 have a cross-sectional width that is more suitable for the zinc alloy mesh stent 200.

One island structure 120 is connected to other island structures after being connected by a plurality of bridge line structures 110. The bridgewire 111 of the bridgewire structure 110 is an arc-curved structure, and can realize tensile or compressive deformation under the action of in-plane stress. Specifically, as shown in fig. 2, the bridge wire 111 includes at least one arc-shaped unit, which may be S-shaped or wavy. Optionally, the cross-sectional width of the bridge wire 111 is 0.4mm to 1mm. Too large a cross-sectional width of the bridgewire 111 affects the deformability of the bridgewire 111, and too small a cross-sectional width of the bridgewire 111 affects the radial support strength of the entire mesh stent 200. The two bridgewire structures 110 are connected by a node 112. The parallel arc line structure design is added in the area of the bridge line 111, so that after the original bearing structure is deformed or degraded, the parallel structure 113 can be further used as a deformation expanding structure and a reticular support maintaining structure.

The diameter of the circumcircle of 1 island bridge structure 100 is 10mm-50mm. Preferably, the diameter of the circle circumscribing the island bridge structure 100 is 20mm. The island structures 120 are too small to be machined and may affect the radial support strength of the mesh stent 200. The island-shaped structures 120 are too large in size, and the space occupied by the bridge wire 110 is smaller on the same size of the net-shaped stent 200, i.e. the deformation capability of the net-shaped stent 200 is affected.

For fixation to the skull, the mesh-like scaffold 200 may be provided with nail holes 210 at the edge of the mesh-like scaffold 200, the nail holes 210 being connected to 2-6 bridgewire structures 110. Specifically, as shown in FIG. 1, the nail holes 210 are connected to 3 bridgewire structures 110. The diameter of the nail hole 210 is 2mm-2.5mm, and the diameter of the nail hole is determined according to the industry standard, and is not further limited in the embodiment.

In this embodiment, the island-shaped structure and the S-shaped bridge line deform to satisfy the expansion or compression deformation of the mesh-shaped scaffold 200 in each direction in the two-dimensional plane, and satisfy the self-shaping ability that the common mesh-shaped scaffold lacks in the skull deformation process, and is particularly suitable for repairing the irregular skull defect of the child in the rapid skull growth period.

The skull repairing net of the invention has the following specific implementation modes:

as shown in fig. 4 and 5, the size, curvature and shape parameters of the defective skull are determined by a three-dimensional scanning mode. The basic size and shape of the mesh support 200 is determined according to the size and shape and curvature of the cranial defect. The skull repairing device mainly comprises three parts, wherein the first part is a bridgewire, the second part is a fixed structure, and the third part is an island-shaped structure. As a more conventional option, each portion may be made separately and then joined by suitable means. In particular, the cranial prosthesis may be made by removing a designated portion of a unitary metal plate, thereby leaving a desired portion of the metal plate. It will be appreciated that the method of separately manufacturing each portion and then splicing them together to form the skull restoration device is less difficult to manufacture. But there may be unexpected difficulties in connecting the various parts. If the skull repairing device is manufactured by removing the designated part from the whole metal plate, the connection problem does not need to be considered among the parts, but the difficulty level of the manufacturing depends on the realization mode and the precision of the device. In the process of repairing operation, fine adjustment is carried out according to the shape of the skull at the defect position so as to meet the requirement of complex shape, and the aim of stable integration is achieved by fixing the nail holes 130 at the boundary with the skull through screws. Although the plastic reticular stent is in a semicircular shape similar to the skull, the reticular stent can still be deformed to a greater degree through the bridgewire structure 110, and the clinical requirements of the repair of the skull of the child are met.

The degradable metal skull repair mesh implant provided by the embodiment of the application is described in detail above. The above description of the embodiments is only for the purpose of helping to understand the method of the present application and its core ideas; meanwhile, for a person skilled in the art, according to the idea of the present application, there may be variations in the specific embodiments and the application scope, and in summary, the content of the present specification should not be construed as a limitation to the present application.

As some terms are used throughout the description and claims to refer to particular components. As one skilled in the art will appreciate, manufacturers may refer to a component by different names. This specification and claims do not intend to distinguish between components that differ in name but not function. In the following description and in the claims, the terms "include" and "comprise" are used in an open-ended fashion, and thus should be interpreted to mean "include, but not limited to. "substantially" means within an acceptable error range, that a person skilled in the art can solve the technical problem within a certain error range to substantially achieve the technical effect. The description which follows is a preferred embodiment of the present application, but is made for the purpose of illustrating the general principles of the application and not for the purpose of limiting the scope of the application. The protection scope of the present application shall be subject to the definitions of the appended claims.

It is also noted that the terms "comprises," "comprising," or any other variation thereof, are intended to cover a non-exclusive inclusion, such that a good or system that comprises a list of elements does not include only those elements but may include other elements not expressly listed or inherent to such good or system. Without further limitation, an element defined by the phrase "comprising a … …" does not exclude the presence of additional like elements in a commodity or system comprising the element.

It should be understood that the term "and/or" as used herein is merely one type of association that describes an associated object, meaning that three relationships may exist, e.g., a and/or B may mean: a exists alone, A and B exist simultaneously, and B exists alone. In addition, the character "/" herein generally indicates that the former and latter related objects are in an "or" relationship.

The foregoing description shows and describes several preferred embodiments of the present application, but as aforementioned, it is to be understood that the application is not limited to the forms disclosed herein, and is not to be construed as excluding other embodiments, but rather is capable of use in various other combinations, modifications, and environments and is capable of changes within the scope of the application as expressed herein, commensurate with the above teachings, or the skill or knowledge of the relevant art. And that modifications and variations may be effected by those skilled in the art without departing from the spirit and scope of the application, which is to be protected by the claims appended hereto.

Claims

1. A degradable metal cranial repair mesh implant, the mesh implant comprising:

a plurality of reticular stents are connected with each other to form a reticular implant;

the bridge wire structure comprises bridge wire arc-shaped units, bridge wire parallel units and two bridge wire node units, wherein the two bridge wire node units are respectively arranged at two ends of each bridge wire arc-shaped unit, and two ends of each bridge wire parallel unit are connected to the bridge wire arc-shaped units;

the bridge wire arc-shaped unit and the bridge wire parallel unit are not less than one, the bridge wire arc-shaped unit comprises an S shape and a wave shape, and the bridge wire parallel unit is in a circular arc shape;

the island-shaped structure comprises at least six island-shaped arc line units, each island-shaped arc line unit comprises an extending part, an extending part and a connecting part, each extending part comprises a plurality of extending arcs which are arranged in parallel, two ends of each extending arc are connected with the extending parts, and the extending parts are connected with the bridge line node units through the connecting parts;

the shape of the extension part comprises an S shape, the connecting part is an arc line, the extension part is used for realizing in-plane deformation parallel to the direction of the reticular stent, and the connecting part is used for realizing out-of-plane deformation perpendicular to the direction of the reticular stent;

the reticular implant is composed of island bridge structures, one island-shaped structure is connected with other island-shaped structures after being connected by a plurality of bridgewire structures, the bridgewire structures and the island-shaped structures are regularly and alternately distributed, the bridgewire structures are used as a first-stage main structure of the reticular stent, the island-shaped structures are used as secondary structures, the island-shaped structure units are designed into arc line designs with hollow interiors, the island-shaped structures can realize out-of-plane deformation in the direction perpendicular to the reticular stent, so that a similar net bag structure is formed, the bridge wire structures can be used as a carrier of medicines and can also provide space for the overall deformation of the stent, the bridgewire structures are arc line bending structures, the deformation of stretching or compression under the action of in-plane stress can be realized, the structural region with stress concentration in the implantation environment is subjected to finite element mechanical analysis by carrying out on the reticular stent, and the connection width of the region is increased by adopting a thickening design mode; the design of parallel arc line structures is added for the area with larger stress concentration, so that after the original bearing structure is deformed or degraded, the parallel structures can be further used as a deformation expanding structure and a reticular support maintaining structure; in order to ensure the supporting function of the reticular stent under the stress condition, the area of the stent occupies 30-50% of the area of the whole region before deformation, so that the uniform reticular stent can still be ensured after the stent is in a stretching state under a larger stress condition.

2. The mesh implant of claim 1, wherein the island structures are hollow, and the hollow is used for carrying a drug.

3. The mesh implant of claim 1, wherein said mesh stent is designed to be thickened by finite element mechanical simulation analysis for structural regions with stress concentration in the implantation environment, wherein the structural regions with stress concentration comprise bridgewire arc units, bridgewire side-by-side units and bridgewire node units, and the width of the connection of the regions is increased.

4. The mesh implant according to claim 1, further comprising an edge support, wherein the edge support is disposed outside the mesh support, the edge support is connected with the mesh support, the edge support is provided with nail holes, and the nail holes are connected with the bridge wire node units.

5. The mesh implant of claim 1, wherein said mesh scaffold is made of a material comprising a zinc alloy, a magnesium alloy, and an iron alloy.

6. The mesh implant of claim 1, wherein the mesh scaffold is a curved structure when adapted to the shape of the skull for a particular application, and a planar structure when used to repair a skull lesion, adapted to the shape of the skull.