CN204951247U - Biodegradable metal blood vessel support - Google Patents
Biodegradable metal blood vessel support Download PDFInfo
- Publication number
- CN204951247U CN204951247U CN201520527330.6U CN201520527330U CN204951247U CN 204951247 U CN204951247 U CN 204951247U CN 201520527330 U CN201520527330 U CN 201520527330U CN 204951247 U CN204951247 U CN 204951247U
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- intravascular stent
- main unit
- biodegradable metals
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- biodegradable
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Abstract
The utility model discloses a biodegradable metal blood vessel support, it is including a plurality of main part structure support ring, a plurality of consecutive the encircleing of main part structure support ring forms the tubular structure, is connected by a plurality of connecting rod between two adjacent main part unit support rings, and every main part structure support ring is including a plurality of main part unit that connects into the wave structure. The utility model discloses the blood vessel support has good holding power, compliance and fatigue strength, can be used to the treatment of periphery blood vessel and coronary vascular stenosis disease.
Description
Technical field
This utility model relates to a kind of medical apparatus and instruments of interventional therapy angiostenosis, is specifically related to a kind of biodegradable metals intravascular stent for the treatment of peripheral blood vessel and coronary artery stenosis or occlusion.
Background technology
In peripheral blood vessel or Percutaneous Intracoronary Arterial Stenting be one of most effective method for the treatment of angiostenosis at present.The development of intravascular stent mainly experienced by from bare metal stent, to bracket for eluting medicament, then arrives the process of Biodegradable scaffold.The intravascular stent medically applied at present, mainly by the manufacture of the medical metal material such as rustless steel, Nitinol, sprays the bracket for eluting medicament of macromolecule drug-carried coat.
Bracket for eluting medicament can suppress smooth muscle cell to regenerate by the release of anti-proliferative drugs, thus reduces the restenosis rate of blood vessel, but metal rack itself is biologically inert, stays in the body for a long time after implant into body, still has the risk that advanced thrombus occurs.When the vascular site generation restenosis of implant frame, must process by performing the operation, due to the permanent support previously implanted, the complexity of operation can be increased further.Biodegradable scaffold is on active service in vivo, and after blood vessel recovers, support is absorbed by the body, and has effectively evaded this problem.Current Biodegradable scaffold mainly contains three kinds: high molecular polymer support, ferroalloy support and magnesium alloy bracket.Biodegradable polymer material has good biocompatibility, but to compare metal material much lower for intensity, hardness, rigidity, and degradable macromolecule support needs to increase string diameter size, and mechanical property still has larger gap with metal rack.Ferroalloy support has good mechanical property, but degradation speed is very low, and active time is long, and after blood vessel wall is recovered, ferroalloy support still keeps comparatively high integrality, has the risk that advanced thrombus occurs equally.
Biodegradable magnesium alloy or zinc alloy material have good mechanical property and biocompatibility, are described as " revolutionary metallic biomaterial ", are the focuses of technical field of biological material research both at home and abroad at present.The Medical magnesium alloy material of up-to-date research and development, achieve uniform, controllable degraded, magnesium alloy bracket not only can provide the high support strength of metal rack, can also be absorbed by the body after 6 ~ 12 months, thus avoid stimulating the long-term foreign body of blood vessel wall, reduce vascular restenosis rate, show huge advantages and potential.
Patent publication No. is disclose the good magnesium alloy blood vessel rack of moderate, the good radial support power of a kind of metal coverage rate, compliance in the utility model patent of CN103110465; Patent publication No. has the magnesium alloy blood vessel rack of excellent mechanical property for magnesium alloy bracket disclosed in the utility model patent of CN2936196Y.The distortion of balloon expandable process is focused in magnesium alloy bracket design disclosed in above two patents, but due to the deformation at room temperature performance that magnesium alloy materials is relatively weak, magnesium alloy bracket is held in process in pressure, support ring arch section far-end easily causes material damage, larger elastical retraction and higher residual stress due to violent stretching plastic deformation; And traditional isometrical arc profile design cannot be held in violent pressure, the most effective dispersive stress in dilatating and deformable, makes magnesium alloy bracket have higher residual stress after strutting, causes regional area to corrode too fast, still have problems in corrosion fatigue life.
Utility model content
The purpose of this utility model is to provide a kind of novel biodegradable metals intravascular stent, this degradable magnesium alloy or kirsite intravascular stent shape, by the design of its special constitutional repeating unit, for support provide good mechanical property, longer effective service life with meet clinical in real requirement to degradable blood vessel bracket.
This utility model is achieved through the following technical solutions:
First aspect, this utility model provides a kind of biodegradable metals intravascular stent, comprise some agent structure support rings, some described agent structure support rings are connected around formation tubular structure successively, connected by several connecting rods between adjacent two main unit support rings, each agent structure support ring comprises several main unit connecting into wavy shaped configuration.
Preferably, described intravascular stent, the described agent structure support ring of its arbitrary neighborhood two is mutually in mirror symmetry.
Preferably, described connecting rod is in " n " shape structure, and by curved portions, two straight shape portions with the two ends being arranged at described curved portions form, and the outside of described curved portions is smooth curve shape, and inner side is the smooth arc curvilinear structures that two symmetries intersect.
Preferably, in described intravascular stent circumference, the quantity of main unit is 4 ~ 8.
Preferably, the connecting rod in described intravascular stent circumference spatially arranges in the shape of a spiral, and quantity is 2 ~ 4.
Preferably, described main unit comprises top, two elliptic arc portions, two straight-bar portions and two inflection curve parts, two described elliptic arc portions are positioned at the two ends at top, and two described straight-bar portions are respectively connected with an elliptic arc portion, and two described inflection curve parts are respectively connected with a straight-bar portion.
Preferably, the top outer of described main unit is provided with protrusion element, and the height of described protrusion element is 0.01 ~ 1mm, and the major axis in described elliptic arc portion is 0.1 ~ 0.5mm, and minor axis is 0.05 ~ 0.40mm.Protrusion element protrusion element
Preferably, the external diameter of described intravascular stent is 1 ~ 5mm, and wall thickness is 0.1 ~ 0.3mm, and length is 10 ~ 100mm; The metallic rod width of main unit is 0.1 ~ 0.3mm, and connecting rod width is 0.06 ~ 0.25mm, and the radius of the centrage semicircular of connecting rod arch section is 0.10 ~ 0.30mm.
Preferably, be made up of magnesium alloy or zinc alloy material.
Second aspect, this utility model additionally provides the application of a kind of biodegradable metals intravascular stent as the aforementioned in coronary artery or peripheral blood vessel treatment.
Compared with prior art, this utility model has following beneficial effect:
1, this biodegradable metals intravascular stent has good biocompatibility, evenly degrades in vivo, and after affected area blood vessel completes positivity reconstruct, support is absorbed by the body, and effectively prevent and stimulates the long-term foreign body of vascular tissue.
2, magnesium alloy or zinc alloy material are in yield strength, percentage elongation, rustless steel is compared in the material mechanical performance aspects such as fracture strength, cochrome, the permanent support materials such as titanium alloy have certain gap, so existing permanent support design is held in pressure, introduce excessive deflection in process of expansion and be not suitable for magnesium alloy or zinc alloy material, this biodegradable metals intravascular stent is by adding inflection, larger distortion circular arc, projection outside distortion arc, the support bar width of smooth change makes pressure hold, stress in process of expansion is concentrated and is significantly improved, plastic deformation is dispersed to larger scope, therefore this biodegradable metals intravascular stent has good radial support power, good compliance, pressure hold and balloon expandable process in homogeneous deformation, not easy fracture, residual stress is low.
3, this biodegradable metals intravascular stent passes through circular arc and the inflection edge contour of intense adjustment, both rigidity are mated mutually, common participation pressure is held, dilatating and deformable, press adjacent steady arm when holding terminal to be parallel to each other and make full use of space, while dispersion plastic deformation, reduce and press the elastic recoil after holding.
4, this biodegradable metals intravascular stent make to press by unique profile design hold, plastic deformation in process of expansion is less, reduces the mechanical damage may introduced in deformation process; When support is on active service, stress is concentrated and is effectively improved, and reduce the corrosion rate of biodegradable metals support in blood environment, therefore this biodegradable metals support has longer corrosion fatigue life, longer effective active time.
5, this utility model support is except being applied to periphery and coronary stricture treatment as intravascular stent, also can be used as the biodegradable stent application of other luminal stenosis treatment, as Esophageal Stent, trachea bracket, biliary tract prosthesis, stents of pancreatic duct, catheter bracket etc.
Accompanying drawing explanation
By reading the detailed description done non-limiting example with reference to the following drawings, other features, objects and advantages of the present utility model will become more obvious:
Fig. 1 is biodegradable metals intravascular stent schematic perspective view of the present utility model;
Fig. 2 is the flat deployable structure schematic diagram of biodegradable metals intravascular stent of the present utility model;
Fig. 3 is the structural front view of main unit in this utility model;
Fig. 4 is the structural front view of connecting rod in this utility model.
In figure: 1, main unit; 2, connecting rod; 3, agent structure support ring; 11, protrusion element; 12, elliptic arc portion; 13, straight-bar portion; 14, inflection curve part; 21, curved portions; 22, straight shape portion.
Detailed description of the invention
Below in conjunction with specific embodiment, this utility model is described in detail.Following examples will contribute to those skilled in the art and understand this utility model further, but not limit this utility model in any form.It should be pointed out that to those skilled in the art, without departing from the concept of the premise utility, some distortion and improvement can also be made.These all belong to protection domain of the present utility model.
embodiment 1
The structure of a kind of biodegradable metals intravascular stent that the present embodiment relates to as shown in figures 1-4, comprise some agent structure support rings 3, some agent structures support 3 rings and are connected around formation tubular structure successively, connected by several connecting rods 2 between adjacent two main unit support rings 3, agent structure support ring 3 comprises several main unit 1 connecting into wavy shaped configuration.
Described intravascular stent, the described agent structure support ring 3 of its arbitrary neighborhood two is mutually in mirror symmetry.
As shown in Figure 4, connecting rod 2 is in " n " shape structure, by curved portions 21, two straight shape portions 22 with the two ends being arranged at curved portions 21 form, and the outside of curved portions 21 is the smooth curve structure of the semicircular through distortion, and inner side is the smooth arc curvilinear structures that two symmetries intersect.
In intravascular stent circumference, the quantity of main unit is 4 ~ 8, is chosen as 8 in the present embodiment; Connecting rod in intravascular stent circumference spatially arranges in the shape of a spiral, and quantity is 2 ~ 4, is 3 in the present embodiment.
As shown in Figure 2, main unit 1 is in the structure being similar to " V " shape, comprise top, two straight-bar portions 13 of 12, two, elliptic arc portion and two inflection curve parts 14, two elliptic arc portions 12 are positioned at the two ends at top, two straight-bar portions 13 are respectively connected with an elliptic arc portion 12, and two inflection curve parts 14 are respectively connected with a straight-bar portion 13.
The top outer of main unit 1 is also provided with protrusion element 11, and the height of protrusion element 11 is 0.01 ~ 1mm, and wherein, the major axis in elliptic arc portion 12 is 0.1 ~ 0.5mm, and minor axis is 0.05 ~ 0.40mm.
Main unit in intravascular stent, connecting rod are by magnesium alloy materials manufacture, and the external diameter of intravascular stent is 1 ~ 5mm, and wall thickness is 0.1 ~ 0.3mm, and length is 10 ~ 100mm; The metallic rod width of main unit is 0.1 ~ 0.3mm, and connecting rod width is 0.06 ~ 0.25mm, and the radius of the centrage semicircular of the curved portions of connecting rod is 0.10 ~ 0.30mm.
This biodegradable metals intravascular stent can, at surface spraying macromolecule drug-carried coat, be held in process of expansion in pressure, and deformation of timbering is even, is conducive to keeping the complete of macromolecule drug-carried coat, the risk reducing coating fold Yu peel off.This biodegradable metals intravascular stent, while the local stress accelerated corrosion avoiding large plastometric set generation stress concentration phenomenon to cause, keeps the good support force of support and compliance.
The most preferred material of described biodegradable metals intravascular stent is Mg-Nd-Zn-Zr magnesium alloy, but be not limited to this magnesium alloy materials, for other biological magnesium alloy and zinc alloy material, because the Parameters variation such as elastic modelling quantity, Poisson's ratio, density are little, according to yield strength, percentage elongation, quiet stress strain curve and expection pressure are held, expanded dimension, and slightly adjusting the internal and external contour line of the elliptic arc part 12 of main unit and the inflection curve part 14 of main unit when not changing main unit 1 shape can be adaptive.
embodiment 2
The biodegradable metals intravascular stent that the present embodiment relates to, the number of the main unit 1 in this intravascular stent circumference is 4 ~ 8, the quantity of connecting rod is 2 ~ 4, connecting rod 2 spatially arranges in the shape of a spiral, and other compositions are identical with specific embodiment 1 with annexation.The biodegradable metals intravascular stent that forms of mode thus, can adjust main unit and connecting rod quantity according to target expansion size, and without the need to doing too much adjustment to concrete main unit profile, can adaptive size in a big way, and there is good compliance.
embodiment 3
The biodegradable metals intravascular stent that the present embodiment relates to, the height of the protrusion element of described main unit end is 0.01 ~ 0.06mm, the major axis of the centrage sub-elliptical circular arc in the elliptic arc portion of main unit is 0.15 ~ 0.35mm, minor axis is 0.10 ~ 0.30mm, and the metallic rod width of main unit is between 0.1mm ~ 0.2mm.
embodiment 4
The biodegradable metals intravascular stent that the present embodiment relates to, the external diameter of intravascular stent is 1mm ~ 5mm, and wall thickness is 0.1mm ~ 0.2mm, and the length of intravascular stent is 10mm ~ 50mm, other composition and annexation identical with detailed description of the invention one.
embodiment 5
The biodegradable metals intravascular stent of present embodiment, introduces the design of inflection curve part 14 in the middle part of the straight-bar of main unit 1, and the radius in elliptic arc portion 12 can be made to increase, and residual stress is disperseed more, and plastic deformation is more even.Take biodegradable magnesium alloy as materials processing intravascular stent, main unit arch section adopts identical design, and kinking design is compared with straight shaft designs, and maximum principal strain declines about 5.2%, and maximum residual stress declines about 7.6%.
Above specific embodiment of the utility model is described.It is to be appreciated that this utility model is not limited to above-mentioned particular implementation, those skilled in the art can make various distortion or amendment within the scope of the claims, and this does not affect flesh and blood of the present utility model.
Claims (9)
1. a biodegradable metals intravascular stent, it is characterized in that, comprise some agent structure support rings, some described agent structure support rings are connected around formation tubular structure successively, connected by several connecting rods between adjacent two main unit support rings, each agent structure support ring comprises several main unit connecting into wavy shaped configuration.
2. biodegradable metals intravascular stent as claimed in claim 1, is characterized in that, described intravascular stent, and the described agent structure support ring of its arbitrary neighborhood two is mutually in mirror symmetry.
3. biodegradable metals intravascular stent as claimed in claim 1, it is characterized in that, described connecting rod is in " n " shape structure, by curved portions, two straight shape portions with the two ends being arranged at described curved portions form, and the outside of described curved portions is smooth curve shape, inner side is the smooth arc curvilinear structures that two symmetries intersect.
4. biodegradable metals intravascular stent as claimed in claim 1, it is characterized in that, in described intravascular stent circumference, the quantity of main unit is 4 ~ 8.
5. biodegradable metals intravascular stent as claimed in claim 1, it is characterized in that, the connecting rod in described intravascular stent circumference spatially arranges in the shape of a spiral, and quantity is 2 ~ 4.
6. the biodegradable metals intravascular stent as described in claim 1,2,4 or 5, it is characterized in that, described main unit comprises top, two elliptic arc portions, two straight-bar portions and two inflection curve parts, two described elliptic arc portions are positioned at the two ends at top, two described straight-bar portions are respectively connected with an elliptic arc portion, and two described inflection curve parts are respectively connected with a straight-bar portion.
7. biodegradable metals intravascular stent as claimed in claim 6, it is characterized in that, the top outer of described main unit is provided with protrusion element, and the height of described protrusion element is 0.01 ~ 1mm, the major axis in described elliptic arc portion is 0.1 ~ 0.5mm, and minor axis is 0.05 ~ 0.40mm.
8. biodegradable metals intravascular stent as claimed in claim 1, it is characterized in that, the external diameter of described intravascular stent is 1 ~ 5mm, and wall thickness is 0.1 ~ 0.3mm, and length is 10 ~ 100mm; The metallic rod width of main unit is 0.1 ~ 0.3mm, and connecting rod width is 0.06 ~ 0.25mm, and the radius of the centrage semicircular of connecting rod arch section is 0.10 ~ 0.30mm.
9. biodegradable metals intravascular stent as claimed in claim 1, is characterized in that, be made up of magnesium alloy or zinc alloy material.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201520527330.6U CN204951247U (en) | 2015-07-20 | 2015-07-20 | Biodegradable metal blood vessel support |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201520527330.6U CN204951247U (en) | 2015-07-20 | 2015-07-20 | Biodegradable metal blood vessel support |
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| Publication Number | Publication Date |
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| CN204951247U true CN204951247U (en) | 2016-01-13 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201520527330.6U Withdrawn - After Issue CN204951247U (en) | 2015-07-20 | 2015-07-20 | Biodegradable metal blood vessel support |
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Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105596125A (en) * | 2016-02-04 | 2016-05-25 | 西安爱德万思医疗科技有限公司 | Pipe-network type intravascular stent formed by material of body absorbable zinc and zinc alloy thereof |
| CN105902331A (en) * | 2016-04-08 | 2016-08-31 | 南京永明医疗器械有限公司 | Intravascular stent and preparation method thereof |
| CN106237397A (en) * | 2016-01-20 | 2016-12-21 | 沈晨阳 | One is applicable to the arterial vascular Biodegradable vascular scaffold of below knee joint |
| WO2017012386A1 (en) * | 2015-07-20 | 2017-01-26 | 上海交通大学 | Biodegradable metal vascular scaffold and use thereof |
| CN106726037A (en) * | 2017-01-04 | 2017-05-31 | 北京航空航天大学 | A kind of PLA base intravascular stent that can uniformly degrade |
| WO2018036434A1 (en) * | 2016-08-23 | 2018-03-01 | 深圳市信立泰生物医疗工程有限公司 | Implant-type, completely bioabsorbable, vascular polymer stent |
| CN109893295A (en) * | 2019-03-26 | 2019-06-18 | 北京航空航天大学 | A kind of negative poisson's ratio degradable blood vessel bracket structure |
| CN110279501A (en) * | 2019-07-18 | 2019-09-27 | 中科益安医疗科技（北京）股份有限公司 | A kind of medical embedded coronary artery bracket |
-
2015
- 2015-07-20 CN CN201520527330.6U patent/CN204951247U/en not_active Withdrawn - After Issue
Cited By (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017012386A1 (en) * | 2015-07-20 | 2017-01-26 | 上海交通大学 | Biodegradable metal vascular scaffold and use thereof |
| CN106691647A (en) * | 2015-07-20 | 2017-05-24 | 上海交通大学 | Biodegradable metal intravascular stent and application thereof |
| CN106691647B (en) * | 2015-07-20 | 2019-05-24 | 上海交通大学 | A kind of biodegradable metals intravascular stent and its application |
| CN106237397A (en) * | 2016-01-20 | 2016-12-21 | 沈晨阳 | One is applicable to the arterial vascular Biodegradable vascular scaffold of below knee joint |
| CN105596125A (en) * | 2016-02-04 | 2016-05-25 | 西安爱德万思医疗科技有限公司 | Pipe-network type intravascular stent formed by material of body absorbable zinc and zinc alloy thereof |
| CN105902331A (en) * | 2016-04-08 | 2016-08-31 | 南京永明医疗器械有限公司 | Intravascular stent and preparation method thereof |
| WO2018036434A1 (en) * | 2016-08-23 | 2018-03-01 | 深圳市信立泰生物医疗工程有限公司 | Implant-type, completely bioabsorbable, vascular polymer stent |
| CN109640882A (en) * | 2016-08-23 | 2019-04-16 | 深圳市信立泰生物医疗工程有限公司 | A kind of complete biological absorbable blood vessel polymer support of implanted |
| CN109640882B (en) * | 2016-08-23 | 2021-03-26 | 深圳市信立泰生物医疗工程有限公司 | Implantable completely-bioabsorbable intravascular polymer stent |
| CN106726037A (en) * | 2017-01-04 | 2017-05-31 | 北京航空航天大学 | A kind of PLA base intravascular stent that can uniformly degrade |
| CN109893295A (en) * | 2019-03-26 | 2019-06-18 | 北京航空航天大学 | A kind of negative poisson's ratio degradable blood vessel bracket structure |
| CN110279501A (en) * | 2019-07-18 | 2019-09-27 | 中科益安医疗科技（北京）股份有限公司 | A kind of medical embedded coronary artery bracket |
| WO2021008599A1 (en) * | 2019-07-18 | 2021-01-21 | 史忠林 | Medical implanted coronary stent |
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| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| AV01 | Patent right actively abandoned |
Granted publication date: 20160113 Effective date of abandoning: 20190524 |
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| AV01 | Patent right actively abandoned |