CN103300951A - Vertebral artery stent - Google Patents
Vertebral artery stent Download PDFInfo
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- CN103300951A CN103300951A CN2013102391151A CN201310239115A CN103300951A CN 103300951 A CN103300951 A CN 103300951A CN 2013102391151 A CN2013102391151 A CN 2013102391151A CN 201310239115 A CN201310239115 A CN 201310239115A CN 103300951 A CN103300951 A CN 103300951A
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- vertebral artery
- dredging
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Abstract
The invention discloses a vertebral artery stent. The vertebral artery stent comprises denser class-I annular units and sparser class-II annular units, which are connected and respectively arranged at the near end and the far end of a vertebral artery to form a tubular structure, wherein each denser class-I annular unit is formed by tandem connection of axially symmetrical U-shaped structures, and each sparser class-II annular unit is formed by tandem connection of axially asymmetrical U-shaped structures. Through the approach, the vertebral artery stent can effectively reduce the incidence of restenosis, provides a good platform for the development of vertebral artery stents, and can realize the purpose of treatment of the starting place of stenosis so as to meet the requirements on vertebral artery stenosis in clinic.
Description
Technical field
The present invention relates to medical instruments field, particularly relate to a kind of vertebral artery support.
Background technology
Cerebrovascular is to cause one of human three dead big principal diseases, and cerebral infarction accounts for 80% in the cerebrovascular, and cerebrovascular stenosis is its most important disease.The vertebral artery initial part narrow in whole cerebrovascular stenosis proportion up to 25-40%.Drug therapy can't be reversed the morphological change that has caused, and this position is because factors such as treatment technology difficulty, risk height are not suitable for surgical operation.(vertebral artery angioplasty and stenting is that invalid a kind of of the narrow patient's Drug therapy of present symptomatic vertebral artery opening treats selection VAS) for vertebral artery angiopoiesis and stent endoprosthesis.Because the limitation of Drug therapy and surgical operation therapy, in conjunction with VAS extensive experience of using in the coronary atherosclerotic disease, its art formula is simple, operation risk is low, complication is few, is considered to the invalid a kind of effective selection of the narrow patient's Drug therapy of vertebral artery opening at present.This method can clearly be improved blood flow, alleviates narrow relevant ischemia symptom, improves prognosis and prevents the generation of ischemic event.
At present, the research report of lot of domestic and foreign shows, the neither one support is that indication designs for the vertebral-basilar artery system, common vertebral artery mounting system is all from coronary artery bracket and intracranial stent, coronary artery bracket mainly contains CypherTM support (U.S. Cordis company) and TAXUSTM support (U.S. Boston company), and intracranial stent mainly contains Apollo support (Shanghai company of Wicresoft) and Wingspan intracranial bracket for eluting medicament.
The form of existing cerebral arteries support is varied, mainly based on intracranial stent, is divided into laser cut stent (patent of invention: 200910088181.7 from manufacture method; Patent of invention: 200910088181.1) and braided support (invention: 201120409581.6) two kinds; 201020659175.0) and cobalt-base alloys support (patent of invention: 200910088181.7 from using material to be divided into nick-eltitanium alloy stent (invention:; Patent of invention: 200910088181.1) two kinds; (invention: 201120409581.6) and covered stnet (is not invented: 201020659175.0 to be divided into covered stnet from structure; Patent of invention: 200910088181.1) two kinds; From whether being with medicine to be divided into bare metal stent (invention: ZL02266010.0) and bracket for eluting medicament (patent of invention: 200910088181.7; Patent of invention: 200910088181.1) two kinds; From expansion method be divided into from swollen support (invention: 201120409581.6,201020659175.0) and balloon expandable stent (patent of invention: 200910088181.7 invention:; Patent of invention: 200910088181.1, invention: ZL02266010.0) two kinds.
At present still there are some problems in these intracranial stent: incompatibility vertebral-basilar artery systems all, just in view of the situation, for the vertebral-basilar artery system is indication, be specially adapted for recovering vertebral artery blood flow state and blood flow increasing, have the effect that the prevention speckle comes off simultaneously, be necessary to carry out research and development and the applied research of novel vertebral artery support.The vertebral-basilar artery support should meet the following requirements: 1) satisfy the balance of support between support force and submissive row; 2) satisfy support at the support force of vertebral artery initial part; 3) solve vertebral artery in the processing of vascular dissection pathological changes; 4) restenosis in the effectively anti-hemostatic tube; 5) bear the fatigue strength of pulse circulation varying load.
Summary of the invention
The technical problem that the present invention mainly solves provides a kind of vertebral artery support, can effectively reduce the generation of restenosis, for the exploitation of vertebral artery support provides good platform, and can realize the purpose of vertebral artery section start narrow treatment, with satisfy clinical in to the needs of vertebral artery narrowing.
For solving the problems of the technologies described above, the technical scheme that the present invention adopts is: a kind of vertebral artery support is provided, comprises a continuous closeer class annular unit and the two class annular units of dredging; A described closeer class annular unit and the described two class annular units of dredging are arranged in vertebral artery near-end and far-end formation tubular structure respectively.
Preferably, a described closeer class annular unit is formed by connecting by the U-shaped structure serial connection of axial symmetry, and the described two class annular units of dredging are formed by connecting by axial asymmetrical U-shaped structure serial connection.
Preferably, the adjacent corresponding circular arc short dowel that passes through at interval of U-shaped structure links to each other in the described closeer class annular unit, and the inside and outside side of the corresponding circular arc that the U-shaped structure is adjacent in the described two class annular units of the dredging long dowel that passes through at interval links to each other.
Preferably, a described closeer class annular unit and the described two class annular unit dowels of dredging are to adopt linear structure, or " V " or " W " or " S " or " N " shape structure.
Preferably, the U-shaped structure of the U-shaped structure of a described closeer class annular unit and the two class annular units dredged is made by one or more materials in rustless steel, cochrome, Nitinol, biodegradable polymers material or biodegradable metal, pure magnesium, magnesium alloy, pure iron or the ferroalloy.
Preferably, the number of the U-shaped structure of a described closeer class annular unit is 1.1-2.0 times of number of the U-shaped structure of the described two class annular units of dredging.
Preferably, the length of straigh line of the U-shaped structure of the described two class annular units of dredging is 1.1-2.0 times of U-shaped structure length of straigh line of a described closeer class annular unit.
Preferably, the straightway width of the U-shaped structure of the described two class annular units of dredging is 1.1-2.0 times of U-shaped structure straightway width of a described closeer class annular unit.
Preferably, to be a described closeer class annular unit participate in 1.1-1.6 times of each U-shaped structure arc section width of being connected with the described two class annular units of dredging for a described closeer class annular unit and width that the described two class annular units of dredging have neither part nor lot in the arc section of each the U-shaped structure that is connected.
Preferably, the width of the straightway of each the U-shaped structure in a described closeer class annular unit and the described two class annular units of dredging be have neither part nor lot in each the U-shaped structure that is connected the arc section width 1.1-1.6 doubly.
The invention has the beneficial effects as follows: a kind of vertebral artery support of the present invention, utilize dowel to connect with respect to traditional supporting structure by single annular unit, adopt two kinds of annular units of density interphase to form, each annular unit interconnects with part U-shaped structure.A described closeer class annular unit and the described two class annular units of dredging are arranged in vertebral artery near-end and far-end formation tubular structure respectively, the expansion back forms conical naturally, the support force of near-end is greater than far-end, thereby be more suitable for treating the needs of vertebral artery narrowing, have good pliability, keep the unobstructed support strength of tremulous pulse, and can bear the fatigue load that pulse causes.
Description of drawings
Fig. 1 is the flat deployable structure sketch map of the conical vertebral artery support of a kind of density interphase of the present invention;
Fig. 2 is the near-end partial enlarged drawing of the conical vertebral artery support of a kind of density interphase of the present invention;
Fig. 3 is the far-end partial enlarged drawing of the conical vertebral artery support of a kind of density interphase of the present invention;
Fig. 4 is the flat deployable structure sketch map of the embodiment two of the conical vertebral artery support of a kind of density interphase of the present invention;
Fig. 5 is the far-end partial enlarged drawing of the embodiment two of the conical vertebral artery support of a kind of density interphase of the present invention;
Fig. 6 is the flat deployable structure sketch map of the embodiment three of the conical vertebral artery support of a kind of density interphase of the present invention;
Fig. 7 is the far-end partial enlarged drawing of the embodiment three of the conical vertebral artery support of a kind of density interphase of the present invention;
Fig. 8 is the flat deployable structure sketch map of the embodiment four of the conical vertebral artery support of a kind of density interphase of the present invention;
Fig. 9 is the flat deployable structure sketch map of the embodiment five of the conical vertebral artery support of a kind of density interphase of the present invention;
Figure 10 is a kind of flat deployable structure sketch map of traditional density interphase arterial bracket;
Figure 11 is the flat deployable structure sketch map of another traditional closed-loop arterial bracket;
Figure 12 is the flat deployable structure sketch map of another conventional open-loop arterial bracket;
Figure 13 is the flat deployable structure sketch map of another traditional short straight rod arterial bracket;
Figure 14 is the concept map of forming support U-shaped structure;
Figure 15 is support bending fatigue strength test synoptic diagram.
The specific embodiment
Below in conjunction with accompanying drawing preferred embodiment of the present invention is described in detail, thereby so that advantages and features of the invention can be easier to be it will be appreciated by those skilled in the art that protection scope of the present invention is made more explicit defining.
Embodiment:
As shown in Figure 1, along on the axis direction of support, the U-shaped structure 3 that one end is open and 3' are around the central shaft C circumferential array of support 1, the two class annular unit 2' axially-aligned that form a closeer class annular unit 2 and dredge, U-shaped structure 2 and 2' by straightway 4 and 4' and arc section 5 and 5' or 6 and 6' form, U-shaped structure 3 and 3' are connected to form tubular structure by dowel 7 and 7', and tubular structure is dilatating and deformable from inside to outside.
A plurality of class U-shaped structures 2 are connected to form a closeer class annular unit 3 with circumferencial direction; A plurality of two class U-shaped structure 2' are connected to form the two class annular unit 3' that dredge with circumferencial direction, and a closeer class annular unit 3 is arranged in the near-end of blood vessel, and the two class annular unit 3' that dredge are arranged in the far-end of blood vessel.One class annular unit 3 and two class annular unit 3' are connected to form the tubular structure of open loop structure respectively with dowel 7 or 7'.Open loop structure mainly is that part U-shaped structure 2 is connected with 2', so the pliability of support is improved.
A closeer class annular unit 3 upwards is symmetrically distributed at support shaft, links to each other with dowel 7 parts, thereby makes support 1 reduce non-uniform phenomenon when expansion, and improve the support force on the unit are.In the present embodiment, can be that the dowel 7 of 0.1～0.5mm connects by length as dowel 7, but comparatively ideally be, the straightway that is shorter in length than U-shaped structure 24 of dowel 7, and the arc top 6 of dowel 7 and corresponding U-shaped structure 2 arc sections directly is connected to form one, adopt arc to push up direct-connected form, maximum stress occur in connecting portion around, thereby the reduction maximum stress improves safety coefficient.
The two class annular unit 3' that dredge partly link to each other with dowel 7', thereby make support 1 reduce axial cripetura rate when expansion, and improve compliance in the support shaft distribution or asymmetrical distribution that makes progress.In the present embodiment, can be that the dowel 7' of 0.5～1.5mm connects by length as dowel 7', but comparatively ideally be, the length of dowel 7' slightly is longer than the straightway 4' of U-shaped structure 2', and dowel 7' directly is connected to form one with the mid point 6' of corresponding U-shaped structure 2' arc section, adopt arc to push up direct-connected form, maximum stress occur in connecting portion around, thereby the reduction maximum stress can improve safety coefficient.
When support is used balloon expandable, form taper shape naturally from the vertebral artery far-end to near-end, circular cone two ends diameter differs 3-10% under nominal pressure.This is because near-end is made up of a closeer class annular unit 2, far-end is made up of the two class annular unit 2' that dredge, and the straightway 4' width of the U-shaped structure 3' of two class annular unit 2' is 1.1-2.0 times of straightway 4 width of the U-shaped structure 3 of a class annular unit 2.U-shaped structure 3 easy deformation more makes proximal diameter greater than distal diameter under identical expansion pressure, forms tubaeform naturally.The shape of vertebral artery section start is similar to taper shape, and circular cone two ends diameter differs 3-10%, and this is conducive to the adherent property of support when treatment vertebral artery section start narrow.
The number of the U-shaped structure 3 of a closeer class annular unit 2 is 1.1-2.0 times than the number of the U-shaped structure 3' of the two class annular unit 2' that dredge.Support expansion back proximal diameter is greater than distal diameter, and in order to improve the support uniformity of support, the number of the U-shaped structure 2' of a class annular unit 2 of composition near-end is more than the number of the U-shaped structure 3' of two class annular units 3 of far-end.And the vertebral artery section start takes place when narrow, and the ratio far-end of near-end design is closeer, is conducive to improve its support performance.
The straightway 4' length of the U-shaped structure 3' of the two class annular unit 2' that dredge is 1.1-2.0 times of U-shaped structure 3 straightways 4 length of a described closeer class annular unit 2.This is when forming taper shape owing to support after by expansion, for fear of the stress of the circular arc place 4 of the U-shaped structure 3 of near-end one class annular unit 2 and 5 greater than the 4' of circular arc place of the U-shaped structure 3' of two class annular unit 2' and the stress of 5', can make stress distribution even, reach unanimity.
The width of each U-shaped structure 3 among a closeer class annular unit 2 and the two class annular unit 2' that dredge and the straightway 4 of 3' and 4' be have neither part nor lot in the arc section 5 of each the U-shaped structure that is connected and 5' width 1.1-1.6 doubly.This is conducive to support when dilatating and deformable, and the stress at arc section 5 and 5' place is tending towards evenly, and maximum stress descends, and improves safety coefficient.
In like manner, the width that a closeer class annular unit 2 and the two class annular unit 2' that dredge have neither part nor lot in the arc section 5 of each U-shaped structure 3 of being connected and 3' and the 5' 1.1-1.6 that to be a described closeer class annular unit 2 participate in each U-shaped structure 3 of being connected and 3' arc section 6 and 6' width with the described two class annular unit 2' that dredge doubly is conducive to improve and expands uniformity.Be easy to generate constraint at connection arc section 6 and 6' place, be unfavorable for distortion, when the equal in length of junction point both sides straightway 4 and 4', angle equates in the time of can guaranteeing to expand, and improves the expansion uniformity.
The straightway 4 and the 4' that form support U-shaped structure 3 and 3', the difference on arc section 5 and 5' and arc section 6 and the 6' width has been avoided when support bending and pressure are held, and structure is not overlapping.And during support flexural deformation, the adjacent supports body can not interfere.Usually, the width of the straightway 4 of the structure of participation connection and 4' is best than arc section 5 and the wide 10-30% of 5'; The width of arc section 5 and 5' is best than arc section 6 and the wide 10-30% of 6'.Less than 10% o'clock, above mentioned effect can not be given full play to, and surpassed at 30% o'clock, and is relatively poor to the uniformity of vessel support.In addition, when stand out is excessive, the expansion uniformity is affected, the support stiffness of connecting portion is descended.
U-shaped structure 3 and 3' are after support expansion, and when being the obtuse angle with the angle of central shaft C, the radial support power of support increases.The angle theta that two straightways 4 of U-shaped structure 3 after the expansion and 3' and 4' form during near 120 ° radial support power increase to maximum.Therefore, design is during support, and when support was expanded to nominal diameter, two straightways 4 of U-shaped structure 3 and 3' and the angle theta of 4' and central shaft C will design at least more than 90 °.
Size of the present invention (stent length and diameter) has no particular limits, with the conventional stent basically identical.Under situation about not expanding, about 5 30 millimeters of length, comparatively desirable in the scope of about 1.5 6.0mm of the diameter after the expansion.The length of a ring-type unit of support, general about 0.5 3.0mm.The length of dowel 7 is about 0.1 0.5mm, and ideal length is 0.2 0.3mm; The length of dowel 7' is about 0.5 1.5mm, and ideal length is 1.0 1.5mm.
The U-shaped structure 3 of one class and two class annular units 2 and 2' and the number that 3' disposes in a circumferential direction are more than 4 or 4.And, if the diameter after the expansion is then answered more than 6 or 6 greater than more than the φ 3.0mm, get between the 6-10 usually.The many 1-4 of a common class annular unit 2 to two class annular unit 2'.Make progress at support shaft, every 10mm configuration is a class and two class annular unit 2 and 2' more than 2, are generally 4-8.When support is expanded to aimed dia (for example φ 3.0, φ 4.0, φ 5.0), above-mentioned θ at least should be more than 90 ℃, be generally 90 ° 120 ° (Figure 14), though the support force of support is improved when surpassing 120 °, but the deflection of arc section is excessive, and expansion can cause the axial LVFS of support to increase.
Two straightways 4 of U-shaped structure 3 and 3' and the lateral symmetry of 4' and central shaft C distribute.The U-shaped structure 3 of support and the thickness of 3' are generally consistent.The width of the support that cochrome is made is generally at 60 120 μ, and thickness is 40 100 μ.The width of the structure of the support that rustless steel is made is generally 80 140 μ, and thickness is 60 120 μ.
The dowel 7 of this support has the version of unloading ring 8, has avoided the stress concentration at junction point place, thereby has improved ruggedness and motility, and pliability and autgmentability are not affected simultaneously.In addition, corresponding U-shaped structure 3 is not all link to each other (open loop type) with 3' mutually, when pressure is held and carry in the blood vessel, even the diameter of support reduces to some extent, 3 and 3' also be unlikely to form three-dimensional stack at the radial direction of support.
As Figure 1-3, a closeer class annular unit 2 should have a point to be connected on the circumferencial direction of support with the U-shaped structure 3 of the two class annular unit 2' that dredge and the dowel 7 of 3' at least, difference according to stent diameter, to adjust in the U-shaped structure 3 of circumferencial direction configuration and the number of 3', generally, when diameter is 3～6mm, U-shaped structure 3 and 3' get 6-10, this moment, dowel 7 was generally got 1-4, corresponding U-shaped structure 3 is connected with part participation among the 3', all the other are for having neither part nor lot in connection, and the existence of this disconnected structure makes the support compliance be improved.
An above-mentioned closeer class annular unit axial length accounts for the 30-60% of total support length., the optimal design ratio is 40-60%., this near-end structural design closeer than far-end is in order to treat the vertebral artery section start when narrow, to be conducive to improve its support performance.By the adjustment on structure and the size, it is high that the two class annular unit support forces that the support force that makes a closeer class annular unit is relatively dredged are wanted, the support force of a general closeer class annular unit be the two class annular unit support forces dredged 1.1-1.5 doubly.
A closeer class annular unit of this support and the two class annular unit dowels of dredging are to adopt linear structure, or " V " or " W " or " S " or " N " shape structure.
Present embodiment, the maximum stress value at place, the arc top of arc section descends when bearing varying load, and the ability of bearing fatigue load is improved, and the uniformity of the stress/distortion when making expansion simultaneously improves, the relative traditional product of spreading performance is improved, and has strengthened dilation procedure and safety.
Material of the present invention is by the SUS-316L rustless steel, marmems such as Ni-Ti alloy, Cu-Al-Mn alloy, titanium alloy, tantalum alloy, manufacturings such as CoCr-L605 cochrome.
In addition, material of the present invention also can be a kind of metal that can decompose in human body (biodegradable metals).The degradable metal comprises pure magnesium, magnesium alloy, pure iron and ferroalloy etc.
In addition, material of the present invention also can be polylactic acid, polyglycolic acid, poly-(lactic acid-6-caprolactone), poly-Biodegradable polymerics such as (glycolic-6-caprolactones).
In addition, on the degradable metal, coat a kind of biodegradable polymer material in vivo.
Planform of the present invention can be utilized the laser engraving one-shot forming.The production process of laser engraving: at first, utilize CAM to create cutting path based on the support Design drawing; Secondly, metal or macromolecular material are carried out cut; At last, improve surface smoothness through overpickling and electrochemical process, make each edge shape mellow and full.
Below, the expansion pressure when the present invention is used, fatigue strength, support force, pliability, axially cripetura rate, rebound degree radially, maximum distortions etc. carry out test evaluation by following method.
[expansion pressure]
With the support of 3.0 millimeters of nominal diameters, insert internal diameter 3.0mm, the artificial blood vessel of external diameter 4.0mm injects normal saline, when shelf inner diameter is expanded to 3.0mm, measures the expansion pressure of sacculus.
[bending fatigue strength]
As shown in figure 15, support is fixed on the equipment two ends, and the left side is fixed, and the right side connects cam, cam is driven by straight galvanic electricity machine, by the promotion of cam, realizes the bending that carriage center partly produces the about 2.0mm of off-center, repeat above operation, till the support fracture, and writing time.
[pliability]
Measure bending stiffness by the four-point bending test method, the assessment pliability.
[axially cripetura]
Support is inserted internal diameter 3.0mm, and external diameter is the artificial blood vessel of 4.0mm, behind the injection normal saline, shelf inner diameter is expanded to 3.0mm, and expansion back measurement bracket length compares with expansion fore-stock length, calculates the cripetura rate, is axial cripetura rate.
[radially resilience]
Support is inserted internal diameter 3.0mm, and external diameter is the artificial blood vessel of 4.0mm, injects normal saline, with sacculus support is expanded to after the internal diameter 3.0mm, and the unloading sacculus is measured the internal diameter varies rate before and after the unloading, is radially rebound degree.
For the intensity angle from material is estimated the distortion that each position of support takes place, support held behind balloon expandable from pressure keep somewhere to endovascular whole process, set up the FEM (finite element) model of support, import corresponding material behavior, utilize computer to carry out simulation analysis, estimated maximum stress/strain and mechanical property.
Present embodiment is compared with the prior art example compares, comparative result is depicted as chart such as table 1 and shown in Figure 15.Present embodiment and Comparative Examples all adopt length 12mm, diameter 1.0mm during contraction, and internal diameter 3.0mm is made by cochrome during expansion.
The specific embodiment of the invention comprises:
Embodiment one: as Fig. 1, Fig. 2, shown in Figure 3.
Technical scheme provided by the invention is: the conical vertebral artery support (Fig. 1) of a kind of density interphase is characterized in that: this vertebral artery support (1) comprises a closeer class annular unit (2) and the two class annular units of dredging (2 '); A described closeer class annular unit (2) and the described two class annular units of dredging (2 ') are arranged in vertebral artery near-end (A) and far-end (B) formation tubular structure respectively; A described closeer class annular unit (2) is formed by connecting by U-shaped structure (3) serial connection that axially (C) is symmetrical, and the corresponding circular arc (6) that wherein a part of U-shaped structure (3) is adjacent links to each other by short straight rod (7); The described two class annular units of dredging (2 ') are formed by connecting by axial (C) asymmetrical U-shaped structure (3 ') serial connection, and the outside is continuous by long straight-bar (7 ') in the corresponding circular arc (6 ') that wherein a part of U-shaped structure (3 ') is adjacent.
Wherein, described support (1) forms taper shape naturally from vertebral artery far-end (B) to near-end (A) when using balloon expandable, and circular cone two ends diameter differs 3-5% under nominal pressure.
Wherein, the number of the U-shaped structure (3) of a described closeer class annular unit (2) is about 1.3 times of number of the U-shaped structure (3 ') of the described two class annular units of dredging (2 ').
Wherein, straightway (4 ') length of the U-shaped structure (3 ') of the described two class annular units of dredging (2 ') is about 1.2 times of U-shaped structure (3) straightway (4) length of a described closeer class annular unit (2).
Wherein, straightway (4 ') width of the U-shaped structure (3 ') of the described two class annular units of dredging (2 ') is about 1.2 times of U-shaped structure (3) straightway (4) width of a described closeer class annular unit (2).
Wherein, a described closeer class annular unit (2) has neither part nor lot in each the U-shaped structure (3 that is connected with the described two class annular units of dredging (2 '), 3 ') arc section (5,5 ') width be that a described closeer class annular unit (2) and the described two class annular units of dredging (2 ') participate in each U-shaped structure (3 of being connected, 3 ') about 1.2 times of arc section (6,6 ') width.
Wherein, a described closeer class annular unit (2) and each the U-shaped structure (3 in the described two class annular units of dredging (2 '), 3 ') straightway (4,4 ') width be each the U-shaped structure (3 that has neither part nor lot in connection, 3 ') about 1.2 times of arc section (5,5 ') width.
Wherein, the described two class annular units of dredging (2 ') are made up of 6 U-shaped structures (3 ').
Wherein, to participate in the number of the U-shaped structure (3,3 ') that is connected be 2 for a described closeer class annular unit (2) and the described two class annular units of dredging (2 ').
Wherein, axial (C) length of a described closeer class annular unit (2) is about 50% of support (1) total length.
Wherein, (7) length of the dowel that links to each other of the U-shaped structure (3) of a described closeer class annular unit (2) is 0.2mm.
Wherein, the length of the dowel (7 ') that links to each other of the U-shaped structure (3 ') of the described two class annular units of dredging (2 ') is 1.4mm.
Wherein, the support force of a described closeer class annular unit (2) is 1.3 times of described two class annular unit (2 ') support forces of dredging.
Wherein, a described closeer class annular unit (2) and described two class annular unit (2 ') dowels of dredging are to adopt linear structure (7,7 '), described two class annular unit (2 ') dowels (7 ') have " N " shape off-load ring (8) structure.
Wherein, described support (1) is by rustless steel, cochrome, Nitinol, and one or more materials in biodegradable polymers material or biodegradable metal, pure magnesium, magnesium alloy, pure iron or the ferroalloy are made.
Wherein, above-mentioned support can be that laser engraving forms.Laser engraving: at first, based on the drawing of design support (1), utilize CAM to create cutting path; Secondly, metal or macromolecule tubing material are carried out cut.
Support of the present invention (1) forms tubular structure at vertebral artery near-end (A) and far-end (B), the expansion back forms conical naturally, the support force of near-end (A) is greater than far-end (B), thereby be more suitable for treating the needs of vertebral artery narrowing, have good adherent property, keep the unobstructed support strength of tremulous pulse, and can bear the fatigue load that pulse causes.
Embodiment two: as Fig. 4, shown in Figure 5.
Support of the present invention (1) comprises a closeer class annular unit (2) and the two class annular units of dredging (2 '); A described closeer class annular unit (2) and the described two class annular units of dredging (2 ') are arranged in vertebral artery near-end (A) and far-end (B) formation tubular structure respectively; A described closeer class annular unit (2) is formed by connecting by U-shaped structure (3) serial connection that axially (C) is symmetrical, and the corresponding circular arc (6) that wherein a part of U-shaped structure (3) is adjacent links to each other by short straight rod (7); The described two class annular units of dredging (2 ') are formed by connecting by U-shaped structure (3 ') serial connection that axially (C) is symmetrical, and the corresponding circular arc (6 ') that wherein a part of U-shaped structure (3 ') is adjacent is linked to each other by serpentine dowel (7 ').
Other are same as embodiment 1.
Embodiment three: as Fig. 6, shown in Figure 7.
Support of the present invention (1) comprises a closeer class annular unit (2) and the two class annular units of dredging (2 '); A described closeer class annular unit (2) and the described two class annular units of dredging (2 ') are arranged in vertebral artery near-end (A) and far-end (B) formation tubular structure respectively; A described closeer class annular unit (2) is formed by connecting by U-shaped structure (3) serial connection that axially (C) is symmetrical, and the corresponding circular arc (6) that wherein a part of U-shaped structure (3) is adjacent links to each other by short straight rod (7); The described two class annular units of dredging (2 ') are formed by connecting by U-shaped structure (3 ') serial connection that axially (C) is symmetrical, and the corresponding circular arc (6 ') that wherein a part of U-shaped structure (3 ') is adjacent is linked to each other by the dowel (7 ') of linear structure.
Other are same as embodiment 1.
Embodiment four: as shown in Figure 8.
Support of the present invention comprises a closeer class annular unit (2) and the two class annular units of dredging (2 '); A described closeer class annular unit (2) is arranged in the support two ends, and the described two class annular units of dredging (2 ') are arranged in the support central part; A described closeer class annular unit (2) is formed by connecting by axial U-shaped structure (3) serial connection of (C) symmetry, and wherein a part of U-shaped structure (3) is continuous by short straight rod (7) with the corresponding circular arc of U-shaped structure (3 ') (6 ') of adjacent two class annular units (2 '); The described two class annular units of dredging (2 ') are formed by connecting by axial (C) asymmetrical U-shaped structure (3 ') serial connection, and the outside is continuous by long straight-bar (7 ') in the corresponding circular arc (6 ') that wherein a part of U-shaped structure (3 ') is adjacent.Other are same as embodiment 1.
Embodiment five: as shown in Figure 9.
Support of the present invention comprises a closeer class annular unit (2) and the two class annular units of dredging (2 '); A described closeer class annular unit (2) is arranged in the support two ends, and the described two class annular units of dredging (2 ') are arranged in the support central part; A described closeer class annular unit (2) is formed by connecting by axial U-shaped structure (3) serial connection of (C) symmetry, and wherein a part of U-shaped structure (3) is continuous by short straight rod (7) with the corresponding circular arc of U-shaped structure (3 ') (6 ') of adjacent two class annular units (2 '); The described two class annular units of dredging (2 ') are formed by connecting by U-shaped structure (3 ') serial connection that axially (C) is symmetrical, and wherein the corresponding circular arc (6 ') of a part of U-shaped structure (3 ') is linked to each other by serpentine dowel (7 ').Other are same as embodiment 1.
Comparative Examples one: as shown in figure 10.
This coronary artery bracket comprises a class annular unit (2) and two class annular units (2 '); A described class annular unit (2) and described two class annular units (2 ') are alternately arranged successively and are formed tubular structure; A described class annular unit (2) and described two class annular units (2 ') are formed by connecting by U-shaped structure (3,3 ') serial connection; The opening direction of the U-shaped structure (3,3 ') that a described class annular unit (2) is adjacent with described two class annular units (2 ') is rightabout; Described U-shaped structure (3,3 ') is made up of straightway and arc section; Part in the U-shaped structure (3) of a described class annular unit (2) the corresponding circle segmental arc adjacent with the U-shaped structure (3 ') of described two class annular units (2 ') is joined by corresponding junction point (7).
Comparative Examples two: as shown in figure 11.
This coronary artery bracket comprises a class annular unit (9) and two class annular units (9 '); A described class annular unit (9) and described two class annular units (9 ') are alternately arranged successively and are formed tubular structure; A described class annular unit (9) and described two class annular units (9 ') are formed by connecting by U-shaped structure (10,10 ') serial connection; The opening direction of the U-shaped structure (10,10 ') that a described class annular unit (9) is adjacent with described two class annular units (9 ') is rightabout; Described U-shaped structure (10,10 ') is made up of straightway and arc section; Part in the U-shaped structure (10) of a described class annular unit (9) the corresponding circle segmental arc adjacent with the U-shaped structure (10 ') of described two class annular units (9 ') is continuous by corresponding " W " shape dowel (11).
Comparative Examples three: as shown in figure 12.
This coronary artery bracket comprises a class annular unit (9) and two class annular units (9 '); A described class annular unit (9) and described two class annular units (9 ') are alternately arranged successively and are formed tubular structure; A described class annular unit (9) and described two class annular units (9 ') are formed by connecting by U-shaped structure (10,10 ') serial connection; The opening direction of the U-shaped structure (10,10 ') that a described class annular unit (9) is adjacent with described two class annular units (9 ') is equidirectional; Described U-shaped structure (10,10 ') is made up of straightway and arc section; Part in the U-shaped structure (10) of a described class annular unit (9) the corresponding circle segmental arc adjacent with the U-shaped structure (10 ') of described two class annular units (9 ') is continuous by corresponding serpentine dowel (11).
Comparative Examples four: as shown in figure 13.
This coronary artery bracket comprises a class annular unit (9) and two class annular units (9 '); A described class annular unit (9) and described two class annular units (9 ') are alternately arranged successively and are formed tubular structure; A described class annular unit (9) and described two class annular units (9 ') are formed by connecting by U-shaped structure (10,10 ') serial connection; The opening direction of the U-shaped structure (10,10 ') that a described class annular unit (9) is adjacent with described two class annular units (9 ') is rightabout; Described U-shaped structure (10,10 ') is made up of straightway and arc section; Part in the U-shaped structure (10) of a described class annular unit (9) the corresponding circle segmental arc adjacent with the U-shaped structure (10 ') of described two class annular units (9 ') is continuous by corresponding straight line dowel (11).
Experimental result
As shown in table 1, the technology of utilizing theory analysis and experimentation to combine, above-mentioned support is compared research, the result shows: at aspects such as expansion pressure, radially resilience, axially cripetura, bending stiffness and flexible lifes, embodiment 1-5 has remarkable advantages than Comparative Examples 1-4, and this is clinically for selecting for use support that good reference frame is provided.
The invention provides the conical vertebral artery support of a kind of density interphase, help the development of support manufacturing technology, the industry contribution is very big, and the probability of industry application is very big.In addition, support of the present invention, it can utilize the manufacturing of tubing cut, so the industrialization manufacturing feasibility is very big.
Table 1 testing experiment result
| ? | Expansion pressure (atm) | Rebound degree (%) radially | Axially cripetura (%) | Bending stiffness (Nmm 2) | Bending fatigue strength (h) |
| Embodiment 1 | 6 | 3.2 | 2.7 | 25 | 12 |
| Embodiment 2 | 6 | 3.5 | 3.1 | 23 | 13 |
| Embodiment 3 | 6 | 3.7 | 3.2 | 31 | 11 |
| |
6 | 3.1 | 2.9 | 28 | 12 |
| |
6 | 3.4 | 3.2 | 27 | 15 |
| Comparative Examples 1 | 8 | 3.8 | 4.6 | 29 | 10 |
| Comparative Examples 2 | 9 | 4.7 | 3.8 | 86 | 2 |
| Comparative Examples 3 | 8 | 4.4 | 3.3 | 54 | 4 |
| Comparative Examples 4 | 8 | 3.9 | 5.5 | 31 | 9 |
A kind of vertebral artery support of the present invention utilizes dowel to connect with respect to traditional supporting structure by single annular unit, adopts two kinds of annular units of density interphase to form, and each annular unit interconnects with part U-shaped structure.A described closeer class annular unit and the described two class annular units of dredging are arranged in vertebral artery near-end and far-end formation tubular structure respectively, the expansion back forms conical naturally, the support force of near-end is greater than far-end, thereby be more suitable for treating the needs of vertebral artery narrowing, have good pliability, keep the unobstructed support strength of tremulous pulse, and can bear the fatigue load that pulse causes.
The above only is embodiments of the invention; be not so limit claim of the present invention; every equivalent structure or equivalent flow process conversion that utilizes description of the present invention and accompanying drawing content to do; or directly or indirectly be used in other relevant technical fields, all in like manner be included in the scope of patent protection of the present invention.
Claims (10)
1. a vertebral artery support is characterized in that: comprise a continuous closeer class annular unit and the two class annular units of dredging; A described closeer class annular unit and the described two class annular units of dredging are arranged in vertebral artery near-end and far-end formation tubular structure respectively.
2. a kind of vertebral artery support according to claim 1, it is characterized in that: a described closeer class annular unit is formed by connecting by the U-shaped structure serial connection of axial symmetry, and the described two class annular units of dredging are formed by connecting by axial asymmetrical U-shaped structure serial connection.
3. a kind of vertebral artery support according to claim 2, it is characterized in that: the adjacent corresponding circular arc short dowel that passes through at interval of U-shaped structure links to each other in the described closeer class annular unit, and the inside and outside side of the corresponding circular arc that the U-shaped structure is adjacent in the described two class annular units of the dredging long dowel that passes through at interval links to each other.
4. a kind of vertebral artery support according to claim 3, it is characterized in that: a described closeer class annular unit and the described two class annular unit dowels of dredging are to adopt linear structure, or " V " or " W " or " S " or " N " shape structure.
5. a kind of vertebral artery support according to claim 2 is characterized in that: the U-shaped structure of the U-shaped structure of a described closeer class annular unit and the two class annular units of dredging is made by one or more materials in rustless steel, cochrome, Nitinol, biodegradable polymers material or biodegradable metal, pure magnesium, magnesium alloy, pure iron or the ferroalloy.
6. a kind of vertebral artery support according to claim 2 is characterized in that: the number of the U-shaped structure of a described closeer class annular unit is 1.1-2.0 times of number of the U-shaped structure of the described two class annular units of dredging.
7. a kind of vertebral artery support according to claim 1 is characterized in that: the length of straigh line of the U-shaped structure of the described two class annular units of dredging is 1.1-2.0 times of U-shaped structure length of straigh line of a described closeer class annular unit.
8. a kind of vertebral artery support according to claim 1 is characterized in that: the straightway width of the U-shaped structure of the described two class annular units of dredging is 1.1-2.0 times of U-shaped structure straightway width of a described closeer class annular unit.
9. a kind of vertebral artery support according to claim 1 is characterized in that: to be a described closeer class annular unit participate in 1.1-1.6 times of each U-shaped structure arc section width of being connected with the described two class annular units of dredging for a described closeer class annular unit and the width that the described two class annular units of dredging have neither part nor lot in the arc section of each the U-shaped structure that is connected.
10. a kind of vertebral artery support according to claim 1 is characterized in that: the width of the straightway of each the U-shaped structure in a described closeer class annular unit and the described two class annular units of dredging be have neither part nor lot in each the U-shaped structure that is connected the arc section width 1.1-1.6 doubly.
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| CN2013102391151A CN103300951A (en) | 2013-06-17 | 2013-06-17 | Vertebral artery stent |
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| CN2013102391151A CN103300951A (en) | 2013-06-17 | 2013-06-17 | Vertebral artery stent |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105167881A (en) * | 2015-09-17 | 2015-12-23 | 江苏大学 | Blood vessel stent resisting to longitudinal deformation |
| CN105596125A (en) * | 2016-02-04 | 2016-05-25 | 西安爱德万思医疗科技有限公司 | Pipe-network type intravascular stent formed by material of body absorbable zinc and zinc alloy thereof |
| CN105902331A (en) * | 2016-04-08 | 2016-08-31 | 南京永明医疗器械有限公司 | Intravascular stent and preparation method thereof |
| CN107049571A (en) * | 2017-05-12 | 2017-08-18 | 微创神通医疗科技（上海）有限公司 | A kind of vertebral artery stent and preparation method thereof |
| WO2019075790A1 (en) * | 2017-10-18 | 2019-04-25 | 科塞尔医疗科技苏州有限公司 | Blood vessel stent |
Citations (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1263450A (en) * | 1997-07-08 | 2000-08-16 | 诺弗Rpsulc | Expandable stent |
| CN101039633A (en) * | 2004-06-30 | 2007-09-19 | 科迪斯公司 | Stent having asymetrical members of unequal length |
| CN201085705Y (en) * | 2007-09-03 | 2008-07-16 | 江苏瑞上医疗器械有限公司 | Laser engraved blood vessel support rigid in radial direction and flexible in longitudinal direction |
| CN101237833A (en) * | 2005-06-20 | 2008-08-06 | S·珍耶那曼 | Structurally variable stents |
| CN201135516Y (en) * | 2007-12-13 | 2008-10-22 | 乐普（北京）医疗器械股份有限公司 | Variable diameter blood vessel support |
| US20080275541A1 (en) * | 2004-11-12 | 2008-11-06 | Icon Interventional Systems, Inc. | Ostial stent |
| CN201308556Y (en) * | 2008-12-15 | 2009-09-16 | 北京有色金属研究总院 | Blood vessel film coating bracket for thoracic aorta interlayer |
| WO2010123387A1 (en) * | 2009-04-23 | 2010-10-28 | Balton Sp. Z.O.O. | Stent for bifurcation and a system for intravascular implantation of the stent for bifurcation |
| CN101926697A (en) * | 2010-07-13 | 2010-12-29 | 北京迈迪顶峰医疗科技有限公司 | Outflow track expandable stent and conveyor thereof |
| CN202776647U (en) * | 2012-07-30 | 2013-03-13 | 赛诺医疗科学技术有限公司 | Vertebral artery support high in metal shielding rate |
| CN203425070U (en) * | 2013-06-17 | 2014-02-12 | 苏州爱瑞德医疗科技有限公司 | Vertebral artery stent |
-
2013
- 2013-06-17 CN CN2013102391151A patent/CN103300951A/en active Pending
Patent Citations (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1263450A (en) * | 1997-07-08 | 2000-08-16 | 诺弗Rpsulc | Expandable stent |
| CN101039633A (en) * | 2004-06-30 | 2007-09-19 | 科迪斯公司 | Stent having asymetrical members of unequal length |
| US20080275541A1 (en) * | 2004-11-12 | 2008-11-06 | Icon Interventional Systems, Inc. | Ostial stent |
| CN101237833A (en) * | 2005-06-20 | 2008-08-06 | S·珍耶那曼 | Structurally variable stents |
| CN201085705Y (en) * | 2007-09-03 | 2008-07-16 | 江苏瑞上医疗器械有限公司 | Laser engraved blood vessel support rigid in radial direction and flexible in longitudinal direction |
| CN201135516Y (en) * | 2007-12-13 | 2008-10-22 | 乐普（北京）医疗器械股份有限公司 | Variable diameter blood vessel support |
| CN201308556Y (en) * | 2008-12-15 | 2009-09-16 | 北京有色金属研究总院 | Blood vessel film coating bracket for thoracic aorta interlayer |
| WO2010123387A1 (en) * | 2009-04-23 | 2010-10-28 | Balton Sp. Z.O.O. | Stent for bifurcation and a system for intravascular implantation of the stent for bifurcation |
| CN101926697A (en) * | 2010-07-13 | 2010-12-29 | 北京迈迪顶峰医疗科技有限公司 | Outflow track expandable stent and conveyor thereof |
| CN202776647U (en) * | 2012-07-30 | 2013-03-13 | 赛诺医疗科学技术有限公司 | Vertebral artery support high in metal shielding rate |
| CN203425070U (en) * | 2013-06-17 | 2014-02-12 | 苏州爱瑞德医疗科技有限公司 | Vertebral artery stent |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105167881A (en) * | 2015-09-17 | 2015-12-23 | 江苏大学 | Blood vessel stent resisting to longitudinal deformation |
| CN105167881B (en) * | 2015-09-17 | 2018-06-01 | 江苏大学 | A kind of intravascular stent with resisting longitudinal deformation |
| CN105596125A (en) * | 2016-02-04 | 2016-05-25 | 西安爱德万思医疗科技有限公司 | Pipe-network type intravascular stent formed by material of body absorbable zinc and zinc alloy thereof |
| CN105902331A (en) * | 2016-04-08 | 2016-08-31 | 南京永明医疗器械有限公司 | Intravascular stent and preparation method thereof |
| CN107049571A (en) * | 2017-05-12 | 2017-08-18 | 微创神通医疗科技（上海）有限公司 | A kind of vertebral artery stent and preparation method thereof |
| WO2019075790A1 (en) * | 2017-10-18 | 2019-04-25 | 科塞尔医疗科技苏州有限公司 | Blood vessel stent |
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