CN106176003B - A kind of intravascular stent, preparation method and application - Google Patents
A kind of intravascular stent, preparation method and application Download PDFInfo
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- CN106176003B CN106176003B CN201610525145.2A CN201610525145A CN106176003B CN 106176003 B CN106176003 B CN 106176003B CN 201610525145 A CN201610525145 A CN 201610525145A CN 106176003 B CN106176003 B CN 106176003B
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- 239000000463 material Substances 0.000 claims description 8
- 238000000034 method Methods 0.000 claims description 8
- 229910052751 metal Inorganic materials 0.000 claims description 7
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- 229910000831 Steel Inorganic materials 0.000 claims 1
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/86—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
- A61F2/90—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
- A61F2/91—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
- A61F2/915—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other
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- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/04—Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
- A61F2/06—Blood vessels
- A61F2/07—Stent-grafts
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/04—Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
- A61F2/06—Blood vessels
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- A61F2002/072—Encapsulated stents, e.g. wire or whole stent embedded in lining
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/86—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
- A61F2/90—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
- A61F2/91—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
- A61F2/915—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other
- A61F2002/91508—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other the meander having a difference in amplitude along the band
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- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/86—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
- A61F2/90—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
- A61F2/91—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
- A61F2/915—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other
- A61F2002/91516—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other the meander having a change in frequency along the band
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/86—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
- A61F2/90—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
- A61F2/91—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
- A61F2/915—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other
- A61F2002/91533—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other characterised by the phase between adjacent bands
- A61F2002/91541—Adjacent bands are arranged out of phase
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/86—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
- A61F2/90—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
- A61F2/91—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
- A61F2/915—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other
- A61F2002/9155—Adjacent bands being connected to each other
- A61F2002/91575—Adjacent bands being connected to each other connected peak to trough
Abstract
The present invention relates to a kind of intravascular stents, preparation method and application, intravascular stent includes location area section and support section, location area section includes multiple first repeated monomers, supporting section includes at least two support units and at least one connection unit, support unit includes multiple second repeated monomers, the number of first repeated monomer is different from the number of the second repeated monomer, the second repeated monomer in the support unit of the rear and front end of support section is connected one to one by the second repeated monomer in the first connection unit and another adjacent support unit to constitute closed loop configuration.Intravascular stent of the invention is especially suitable for iliac vein, it is good to the support effect of iliac vein, and it is small to the damage of wall of vein, the formation of secondary thrombus in intravascular stent implantation after-poppet can effectively be avoided, furthermore, intravascular stent of the invention can be good at being positioned in iliac vein, improve the accuracy of release, easy to operate.
Description
Technical field
The invention belongs to medical instruments fields, and in particular to a kind of intravascular stent, preparation method and application.
Background technique
Venous disease is most commonly seen in vascular surgery disease, especially lower-limb deep veins thrombus and lower limb great saphenous vein
Varicose is more common.And both diseases are formed by reason that have be greatly caused by iliac vein compression.Iliac vein by
Pressure syndrome (iliacveincompressionsyndrome, IVCS) means that iliac vein is oppressed by common iliac artery, causes intracavitary viscous
Even, narrow or occlusion, so that the syndrome of range of clinical symptom occurs, also known as May-Thurner, Cockett syndrome.Ilium is quiet
Arteries and veins iliac vein incidence is 20%~34%.
Compression of vein is solved to perform the operation always in the treatment, due to needing to perform the operation into abdomen, wound is larger, and patient is difficult always
To receive, thus it is less in the operation number of cases of China's report.Cause many patient's lower extremity swelling and distensions that can not solve, have some patientss because
The blood stasis of blood is stagnant to there is phlebothrombosis.From the development of the 1990s interventional technique, the country begins through balloon expandable, branch
The method of frame implantation solves iliac vein compression, and by nearly 20 years clinical treatments, the method for interventional therapy is vascular surgery
Boundary is received, simultaneously because wound is small, patient can also receive, and the present country has many hospitals to carry out this work.Simultaneously
There are also the patients that the technology is used for iliac vein thrombosis sequelae by many doctors.With being significantly increased for clinical disease number of cases,
And clinic treats always the patient of detection of iliac vein compression syndrome using the biggish arterial bracket of bore at present, to occur one
A important problem, i.e., the probability of secondary thrombus is higher in bracket, this small with arterial bracket mesh and iliac vein structure is led
Cause arterial bracket that must protrude into 1-1.5 centimetres of inferior caval vein, and its support force is not for caused by designed by vein.
Currently, display, the bracket designed using detection of iliac vein compression syndrome as indication are reported in the research of lot of domestic and foreign
It is less.The country can be taken off self-inflated bone vein bracket and (utility model: 201520126120.6) effectively prevent deep veins of lower limb
Pulmonary embolism caused by thrombus breaks loose can avoid bracket long-term after completing therapeutic purposes through jugular vein or the taking-up of femoral vein approach
Indwelling generates complication.For treating the narrow bracket of iliac vein (utility model: 201320053442.3) by nickel-titanium metal silk
The latticed network management being coiled into is woven, network management front end nozzle face is inclined-plane, and the angle on inclined-plane and network management section is 40 degree, is had on network management
The label circle of ellipse realizes accurate positioning.But these bone vein brackets still have some problems: not all being suitable for restoring
Bone venous blood flow state and increase blood flow, and it is easy to cause the formation of thrombus, thus it is necessary to carry out novel bone venous branch
The research and development and application study of frame.
Summary of the invention
The technical problem to be solved by the present invention is to overcome the deficiencies of the prior art and provide a kind of blood vessel branch that structure is different
Frame, preparation method and application, which, which has, is not easily formed thrombus, and histocompatbility is good, to the support force of vein
Blood flow suitably and is not influenced, structure is simple, easy to operate, accurate positioning, can satisfy in clinic to the needs of iliac vein treatment.
In order to solve the above technical problems, the present invention adopts the following technical scheme:
It is an object of the present invention to provide a kind of intravascular stents, can be from the compression shape with first cross-sectional diameter
State changes to the expansion state with the second cross-sectional diameter being extended,
The intravascular stent includes the location area section and support being connected on the axis direction of the intravascular stent
Section,
The location area section includes circumferentially distributed multiple first repeated monomers along the intravascular stent,
The support section includes at least two supports to adjoin one another on the axis direction of the intravascular stent
Unit and at least one connection unit, the support unit include circumferentially distributed multiple the along the intravascular stent
Two repeated monomers,
The number of first repeated monomer is different from the number of the second repeated monomer, positioned at the support
The second repeated monomer in the support unit of the rear and front end of section passes through first connection unit and adjacent
The second repeated monomer in support unit described in another connects one to one to constitute closed loop configuration.
According to embodiment of the present invention, it is single to be less than second repetition for the number of first repeated monomer
The number of body.
Preferably, the number of second repeated monomer is 2 ~ 4 times of the number of first repeated monomer, described
The first repeated monomer number be 4 to 10.
Further, the front end of the support section is connected with the first developing cell.
According to a preferred aspect of the present invention, the front end of the second repeated monomer of the support section is connected with
One developing cell, the number of the first developing cell can be equal with the number of first repeated monomer or differ.
In the present invention, the first repeated monomer can be connected with the second repeated monomer, can also be connected with connection unit.
According to embodiment of the present invention, the axis of the extending direction of the location area section and the intravascular stent
The angle in line direction is 0 ° ~ 60 °.
Preferably, when the angle of the extending direction of the location area section and the axis direction of the intravascular stent is 0 °
When, the intravascular stent is substantially in cylindrical body；When the extending direction of the location area section and the axis of the intravascular stent
When line direction has angle, the location area section from the one end that is connected with the support section towards front end gradually
Extend away from the direction of the axis of the intravascular stent.
According to a preferred aspect of the present invention, the front end of first repeated monomer is fillet, the circular arc of fillet
Internal diameter radius is more than or equal to 0.1mm.
According to a preferred aspect of the present invention, the length of first repeated monomer be 5 ~ 15mm, preferably 10 ~
15mm；The length of the support section is 40 ~ 140mm, preferably 60 ~ 120mm；The intravascular stent with a thickness of 0.1 ~
0.3mm。
According to embodiment of the present invention, the length of second repeated monomer is 1 ~ 7mm, preferably 2 ~ 5mm.
Preferably, the rear end of the support section is connected with multiple second developing cells.It is further preferable that described
The number of second developing cell is 3 to 10.
A specific embodiment according to the present invention, the connection unit include the week along the intravascular stent
To multiple connectors of distribution, the number of the connector is not more than the number of second repeated monomer.
Specifically, the number of the connector in the connection unit of the rear and front end of the described support section with
The number of second repeated monomer is equal, the connection in the connection unit at the middle part of the support section
The number of body is less than the number of second repeated monomer.
Preferably, the width of the connector is 0.1 ~ 0.3mm.
In the present invention, the width of the connector is equal with the width of the first repeated monomer.
In the present invention, regular width, such as 0.1 ~ 0.3mm is can be used in the width of second repeated monomer.
A specific embodiment according to the present invention, the front end of multiple first repeated monomers are formed by flat
The axis perpendicular in face and the intravascular stent.
A specific embodiment according to the present invention, the front end of multiple first repeated monomers are formed by flat
The angle of the axis of face and the intravascular stent is 45 ° ~ 89 °.
In the present invention, the material of the intravascular stent is stainless steel, memorial alloy, titanium alloy, tantalum alloy, the conjunction of cobalt chromium
One of gold, biodegradable metals, biodegradable polymer, magnesium alloy, pure iron are a variety of.
It is a further object to provide a kind of preparation methods of above-mentioned intravascular stent, by material according to support Design
Path on drawing is cut by laser, and then handles to obtain the intravascular stent through pickling, electrochemical process.
Certainly, intravascular stent of the invention can also be prepared using other methods, for example, braiding or welding.
Third object of the present invention is to provide a kind of stent delivery systems comprising above-mentioned intravascular stent.
Fourth object of the present invention is to provide a kind of purposes of above-mentioned intravascular stent in bifurcated vessels.
Preferably, the present invention provides a kind of purposes of above-mentioned intravascular stent in iliac vein.
The front of intravascular stent is defined as in the present invention, with side where location area section to support side where section to be defined as blood
The rear of pipe holder.
Angle defined in the present invention is the angle less than 90 ° formed between straight line and plane or straight line and straight line.
The total length of intravascular stent in the present invention refers to the front end of the first repeated monomer to the second developing cell most
Long vertical range.The length of first repeated monomer and the second repeated monomer refers to front end to the rear end of each repeated monomer
Vertical range.The length of support section refers to the first developing cell to the vertical range between the second developing cell.
Due to the implementation of above-mentioned technical proposal, the invention has the following advantages over the prior art:
Intravascular stent of the invention is good to the support effect of iliac vein especially suitable for iliac vein, and to the wound of wall of vein
Evil is small, can effectively avoid the formation of secondary thrombus in intravascular stent implantation after-poppet, the present invention will be by that will support section both ends
Closed loop configuration is formed, centre uses open loop structure, can be good at the support force for improving both ends, is conducive to both ends after bracket release
Support uniformity and expansion uniformity, to reduce damage to vascular wall.In addition, intravascular stent of the invention can be very
Good is positioned in iliac vein, improves the accuracy of release, easy to operate, the structure letter of intravascular stent of the invention
It is single, it is convenient for production, it is at low cost, to have important practical significance and good potential applicability in clinical practice.
Detailed description of the invention
Fig. 1 is that the intravascular stent of embodiment 1 is implanted in the schematic diagram (extending direction and blood vessel of location area section in iliac vein
The axis direction of bracket is consistent)；
Fig. 2 is that the intravascular stent of embodiment 1 is launched into the structural schematic diagram of plane；
Fig. 3 is the perspective view (extending direction and intravascular stent of location area section of the intravascular stent in expansion state of embodiment 1
Axis direction it is consistent)；
Fig. 4 is perspective view of the intravascular stent in expansion state of embodiment 1 (location area section is in bell shape)；
Fig. 5 is the enlarged drawing of the first connector；
Fig. 6 is the enlarged drawing of the first repeated monomer；
Fig. 7 is that the intravascular stent of embodiment 2 is launched into the structural schematic diagram of plane；
Fig. 8 is the perspective view (extending direction and intravascular stent of location area section of the intravascular stent in expansion state of embodiment 2
Axis direction it is consistent)；
Fig. 9 is perspective view of the intravascular stent in expansion state of embodiment 2 (location area section is in bell shape)；
Figure 10 is the schematic diagram that the intravascular stent of embodiment 1 is implanted in iliac vein (location area section is in bell shape)；
Figure 11 is that the intravascular stent of embodiment 2 is implanted in the schematic diagram (extending direction and blood of location area section in iliac vein
The axis direction of pipe holder is consistent)；
Figure 12 is the schematic diagram that the intravascular stent of embodiment 2 is implanted in iliac vein (location area section is in bell shape)；
Wherein: 1, location area section；11, the first repeated monomer；2, central support section；21, support unit；211, the second weight
Multiple monomer；22, connection unit；221, connector；4, the first developing cell；5, the second developing cell；β is the first repeated monomer
Front end is formed by the angle of the axis of plane and intravascular stent；W1 is the width of connector；W3 is the first repeated monomer
Width；W4 is the width of the second repeated monomer；L1 is the length of the first repeated monomer；L2 is the length for supporting section；L4 is
The length of two repeated monomers；L6 is total length of the intravascular stent in expansion state.
Specific embodiment
The present invention will be further described in detail combined with specific embodiments below, but the present invention is not limited to following implementations
Example.
Intravascular stent of the invention is primarily adapted for use in bifurcated vessels, especially suitable for (such as Fig. 1) in iliac vein.By blood
During pipe holder is implanted into iliac vein, intravascular stent is mounted in the conveyer of stent delivery system, at this point, at intravascular stent
In compressive state, after intravascular stent is delivered to suitable position by conveyer, intravascular stent is discharged, intravascular stent expands outwardly to
Expansion state, to play a supporting role to iliac vein, intravascular stent has the first cross section in compressive state, in expansion shape
There is the second cross section, also, the diameter of the first cross section is less than the diameter of the second cross section when state state.In the present invention, the
One cross section and the second cross section are the cross section for supporting section 2, and the axis perpendicular of the cross section and intravascular stent.This reality
It applies in example, the outer diameter of the second cross section is 10 ~ 20mm, preferably 12 ~ 16mm.
The material of intravascular stent is stainless steel, memorial alloy, titanium alloy, tantalum alloy, cochrome, biodegradable gold
One of category, biodegradable polymer, magnesium alloy, pure iron are a variety of.SUS-316L stainless steel etc. can be used in stainless steel.Note
Recalling alloy can be used Ni-Ti alloy, Cu-Al-Mn alloy etc..CoCr-L605 cochrome etc. can be used in cochrome.Biology can
Degradation metal is a kind of metal, such as pure magnesium, magnesium alloy, pure iron and ferroalloy etc. that can be decomposed in human body.Biodegradable
Polymer can be polylactic acid, polyglycolic acid, poly- (lactic acid -6-caprolactone), the biodegradables such as poly- (glycolic -6-caprolactone)
Polymer.In addition, a kind of biodegradable polymer material can also be coated as blood vessel branch in vivo in degradable metal
The material of frame.
Intravascular stent of the invention can use laser engraving one-pass molding.The production process of laser engraving: firstly, being based on
Support Design drawing creates cutting path using CAM；Secondly, being cut by laser to metal or high molecular material；Finally, by
Pickling and electrochemical process improve surface smoothness, keep each edge shape mellow and full.
As shown in Figures 2 and 3, intravascular stent includes the positioning area connected from front to back on the axis direction of intravascular stent
Section 1 and support section 2.
Location area section 1 includes circumferentially distributed multiple first repeated monomers 11 along intravascular stent.
Support section 2 includes at least two support units 21 to adjoin one another on the axis direction of intravascular stent and at least
One connection unit 22, support unit 21 include circumferentially distributed multiple second repeated monomers 211 along intravascular stent, connection
Unit 22 includes circumferentially distributed multiple connectors 221 along intravascular stent, and the number of connector 221 is not more than the second repetition
The number of monomer 211.The second repeated monomer 211 in the support unit 21 of the rear and front end of support section 2 passes through first
The second repeated monomer 211 in connector 221 and another adjacent support unit 21 in connection unit 22, which corresponds, to be connected
It connects to constitute closed loop configuration, therefore, the number of the connector 221 in the connection unit 22 of the rear and front end of support section 2
It is equal with the number of the second repeated monomer 211, of the connector 221 in the connection unit 22 at the middle part of support section 2
Number is less than the numbers of the second repeated monomer 211, it is preferable that the number of the second repeated monomer 211 in each support unit 21 is
221 several 2 ~ 3 times of connector in each connection unit 22.Therefore, the support unit positioned at the middle part of support section 2 is to open
Ring structure.
The structure of the first repeated monomer 11 and the second repeated monomer 211 in the present invention, which can be, is capable of forming any of hole
Shape, such as V-type, grid type, diamond shape etc..Distribution mode of the connector 221 on entire intravascular stent can be arbitrary, example
Such as form of straight lines, V-type, W type, S type, N-type.
In the present invention, the front end of support section 2 is connected with the first developing cell 4, in the present embodiment, support section 2
The front end of second repeated monomer 211 is connected with the first developing cell 4, and the setting of the first developing cell 4 enables intravascular stent
It is enough to realize positioning well, facilitate doctor to find point of release accurately.
In the present embodiment, the rear end of the first repeated monomer 11 is connected with the front end of the second repeated monomer 211.
In the present invention, the number of the first repeated monomer 11 is 4 to 10, and the number of the first developing cell 4 is repeated with first
The number of monomer 11 is equal or different.
In the present invention, the rear end of support section 2 is connected with multiple second developing cells 5, the number of the second developing cell 5
It is 3 to 10, also, the number of the second developing cell 5 is equal with the number of the first developing cell 4.In the present embodiment, second is aobvious
Shadow unit 5 can be connected with support unit 21, or be connected with connection unit 22, and the second developing cell 5 is along blood vessel branch
The circumferential direction of frame is uniformly distributed.
In the present invention, the number of the first repeated monomer 11 is different from the number of the second repeated monomer 211.Preferably, first
The number of repeated monomer 11 is less than the number of the second repeated monomer 211, and in the present embodiment, the number of the second repeated monomer 211 is
2 ~ 4 times of the number of first repeated monomer 11 as shown in Figure 1 will so that the aperture for guaranteeing that the first repeated monomer 11 is formed is larger
After intravascular stent is implanted into iliac vein, when location area section 1 extends to inferior caval vein, it can be avoided because the aperture of intravascular stent is smaller to leading
It causes the formation of thrombus and location area section 1 is avoided to impact the blood flow of opposite iliac vein.
In the present embodiment, the angle of the axis direction of the extending direction and intravascular stent of location area section 1 is 0 ° ~ 45 °.Such as figure
Shown in 3, the extending direction of location area section 1 and the axis direction of intravascular stent are consistent, i.e., angle is 0 °, at this point, intravascular stent exists
It is substantially in cylinder type when expansion state.As shown in figure 4, the extending direction of location area section 1 and the axis direction of intravascular stent are deposited
In angle, also, location area section 1 from the one end being connected with support section 2 towards front end gradually away from blood vessel branch
The direction of the axis of frame extends, i.e., location area section 1 is in the bell shape gradually expanded outwardly from back to front.
In the present embodiment, the width W1(of connector 221 is as shown in Figure 5) it is 0.1 ~ 0.3mm.The width W1 of connector 221
It is as shown in Figure 6 with the width W3(of the first repeated monomer 11) it is equal.The width W4(of second repeated monomer 211 is as shown in Figure 5) it can
To use regular width, such as 0.1 ~ 0.3mm.
In the present embodiment, 0.1 ~ 0.3mm(of thickness of intravascular stent is not shown), the thickness of intravascular stent refers to blood vessel branch
The outer diameter of the cross section of frame and the difference of internal diameter.
In the present embodiment, the front end of the first repeated monomer 11 is fillet, and the circular arc internal diameter radius of fillet is greater than 0.1mm
(not shown), to reduce stimulation of the intravascular stent to blood vessel.
In the present embodiment, the length L1 of the first repeated monomer 11 is 5 ~ 15mm, preferably 10 ~ 15mm, the first repeated monomer
11 length is too long, and the front end that will lead to the first repeated monomer 11 touches the vascular wall on opposite and causes the stimulation to blood vessel
Deng adverse effect；The length of first repeated monomer 11 is too short, then will affect positioning of the intravascular stent in iliac vein, so that blood vessel
Bracket can not steadily be implanted in required position.
The length L2 of support section 2 is that the length L4 of the repeated monomer 211 of 40 ~ 140mm, preferably 60 ~ 120mm, second is 1
~ 7mm, preferably 2 ~ 5mm.That is, support section 2 generally comprises 16 support units 21, certainly, the number of support unit 21 can also
To be adjusted according to actual needs.
The total length L 6 of intravascular stent of the invention in expansion state is 50 ~ 120mm, preferably 60 ~ 100mm.
Embodiment 1 is identical with the above content of embodiment 2, difference only with: in embodiment 1, multiple first repeated monomers
11 front end is formed by the axis perpendicular of plane and intravascular stent, as shown in Figures 2 and 3.In embodiment 2, Duo Ge
The front end of one repeated monomer 11 is formed by plane and intersects with the axis of intravascular stent, and multiple first repeated monomers 11
The angle β that front end is formed by the axis of plane and intravascular stent is 45 ° ~ 89 °, as shown in Figs. 7-9, wherein Fig. 7 to 9
In, the angle β that the front end of multiple first repeated monomers 11 is formed by the axis of plane and intravascular stent is 70 °, embodiment 2
In, the length of the first repeated monomer 11 gradually changes, and still, length range should be in the first repeated monomer of above-mentioned restriction
Within 11 length range.
The present invention is described in detail above, its object is to allow the personage for being familiar with this field technology that can understand this
The content of invention is simultaneously implemented, and it is not intended to limit the scope of the present invention, and the present invention is not limited to above-mentioned implementations
, equivalent change or modification made by all Spirit Essences according to the present invention should be covered by the protection scope of the present invention.
Claims (9)
1. a kind of iliac vein intravascular stent, it can change to have from the compressive state with first cross-sectional diameter and be extended
Second cross-sectional diameter expansion state, it is characterised in that:
The intravascular stent includes the location area section (1) being connected on the axis direction of the intravascular stent and Support
Section (2),
The location area section (1) includes circumferentially distributed multiple first repeated monomers (11) along the intravascular stent,
The support section (2) includes at least two support lists to adjoin one another on the axis direction of the intravascular stent
First (21) and at least one connection unit (22), each support unit (21) include the week along the intravascular stent
To multiple second repeated monomers (211) of distribution,
The number of second repeated monomer (211) on each support unit (21) is that first repetition is single
2 ~ 4 times of the number of body (11) and first repeated monomer (11) be formed by aperture and be greater than described second to repeat
Monomer (211) is formed by aperture, and the number of first repeated monomer (11) is 4 to 10, positioned at the Support
The second repeated monomer (211) in the support unit (21) of the rear and front end of section (2) passes through the connection unit
(22) it connects one to one with the second repeated monomer (211) in the support unit (21) described in adjacent another to constitute and close
Ring structure；
Each connection unit (22) includes circumferentially distributed multiple connectors (221) along the intravascular stent,
The width of the connector (221) is 0.1 ~ 0.3 mm；
The number of connector (221) in the connection unit (22) of the rear and front end of the support section (2)
It is equal with the number of the second repeated monomer (211) on each support unit (21), positioned at the support
The number of connector (221) in the connection unit (22) of each of middle part of section (2) is less than each support
The number of second repeated monomer (211) on unit (21)；The length of first repeated monomer (11) be 5 ~
15mm, the length of the support section (2) are 40 ~ 140mm, the intravascular stent with a thickness of 0.1 ~ 0.3mm.
2. iliac vein intravascular stent according to claim 1, it is characterised in that: the front end of the support section (2)
It is connected with the first developing cell (4).
3. iliac vein intravascular stent according to claim 1, it is characterised in that: the extension side of the location area section (1)
Angle to the axis direction with the intravascular stent is 0 ° ~ 60 °.
4. iliac vein intravascular stent according to claim 1, it is characterised in that: before first repeated monomer (11)
End is fillet, and the circular arc internal diameter radius of fillet is more than or equal to 0.1mm.
5. iliac vein intravascular stent according to claim 1, it is characterised in that: the rear end of the support section (2)
Multiple second developing cells (5) are connected with, the number of second developing cell (5) is 3 to 10.
6. iliac vein intravascular stent according to claim 1, it is characterised in that: multiple first repeated monomers (11)
Front end be formed by the axis perpendicular of plane Yu the intravascular stent.
7. iliac vein intravascular stent according to claim 1, it is characterised in that: multiple first repeated monomers (11)
To be formed by the angle of the axis of plane and the intravascular stent be 45 ° ~ 89 ° for front end.
8. iliac vein intravascular stent according to claim 1, it is characterised in that: the material of the intravascular stent is stainless
One of steel, memorial alloy, biodegradable metals, biodegradable polymer, pure iron are a variety of.
9. a kind of preparation method of such as iliac vein intravascular stent described in any item of the claim 1 to 8, it is characterised in that: will
Material is cut by laser according to the path on support Design drawing, then handles to obtain through pickling, electrochemical process described
Intravascular stent.
Priority Applications (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610525145.2A CN106176003B (en) | 2016-07-06 | 2016-07-06 | A kind of intravascular stent, preparation method and application |
| US15/737,365 US10695201B2 (en) | 2016-04-27 | 2016-07-11 | Intravascular stent, preparation method and use thereof |
| EP16900039.5A EP3449878A4 (en) | 2016-04-27 | 2016-07-11 | Vascular stent, preparation method therefor, and application thereof |
| PCT/CN2016/089590 WO2017185529A1 (en) | 2016-04-27 | 2016-07-11 | Vascular stent, preparation method therefor, and application thereof |
| US16/878,320 US11471309B2 (en) | 2016-04-27 | 2020-05-19 | Intravascular stent, preparation method and use thereof |
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| CN201610525145.2A CN106176003B (en) | 2016-07-06 | 2016-07-06 | A kind of intravascular stent, preparation method and application |
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| CN106176003B true CN106176003B (en) | 2018-12-28 |
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| CN106821563B (en) * | 2017-03-15 | 2018-11-02 | 山东吉威医疗制品有限公司 | A kind of holder for branch vessel opening lesion |
| CN110292471A (en) * | 2019-08-01 | 2019-10-01 | 吴忠隐 | A kind of vein bracket |
| EP4164555A4 (en) * | 2020-06-16 | 2023-08-09 | Suzhou Venmed Technology Co., Ltd. | Intravascular stent |
Citations (2)
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|---|---|---|---|---|
| CN2917584Y (en) * | 2004-09-30 | 2007-07-04 | 大连理工大学 | Laser etching nickel-titanium alloy self-swelling type jumping-proof supporting stand |
| CN203408130U (en) * | 2013-08-12 | 2014-01-29 | 万瑞飞鸿(北京)医疗器材有限公司 | Self-expansion carotid artery covered stent |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100566681C (en) * | 2002-09-27 | 2009-12-09 | 医学技术设备公司 | Has the implantable stent that improves the end |
| US20090118810A1 (en) * | 2002-09-27 | 2009-05-07 | Medlogics Device Corporation | Stent assembly system |
| US7001425B2 (en) * | 2002-11-15 | 2006-02-21 | Scimed Life Systems, Inc. | Braided stent method for its manufacture |
| CN2710576Y (en) * | 2004-03-10 | 2005-07-20 | 杨大智 | Laser curved 'quasi sine' tube type nickel titanium alloy support |
| CN105726174B (en) * | 2016-04-27 | 2018-06-29 | 苏州天鸿盛捷医疗器械有限公司 | A kind of intravascular stent, preparation method and application |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN2917584Y (en) * | 2004-09-30 | 2007-07-04 | 大连理工大学 | Laser etching nickel-titanium alloy self-swelling type jumping-proof supporting stand |
| CN203408130U (en) * | 2013-08-12 | 2014-01-29 | 万瑞飞鸿(北京)医疗器材有限公司 | Self-expansion carotid artery covered stent |
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Inventor after: Feng Haiquan Inventor after: Li Xiaoqiang Inventor after: Cao Ping Inventor after: Wang Xiaotian Inventor after: Tang Lie Inventor after: Wang Yonggang Inventor before: Feng Haiquan Inventor before: Li Xiaoqiang Inventor before: Wang Xiaotian Inventor before: Tang Lie Inventor before: Wang Yonggang |
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Address after: Rooms 202, 501, and 502, Building 7, No. 188 Fuchunjiang Road, High tech Zone, Suzhou City, Jiangsu Province, 215000 Patentee after: SUZHOU VENMED TECHNOLOGY Co.,Ltd. Country or region after: China Address before: 215163 south 2nd floor, building 11, No.8 Jinfeng Road, science and Technology City, Suzhou high tech Zone, Jiangsu Province Patentee before: SUZHOU VENMED TECHNOLOGY Co.,Ltd. Country or region before: China |