CN112603959A - Preparation process of Chinese patent medicine for treating chronic pharyngitis - Google Patents

Preparation process of Chinese patent medicine for treating chronic pharyngitis Download PDF

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Publication number
CN112603959A
CN112603959A CN202011529120.2A CN202011529120A CN112603959A CN 112603959 A CN112603959 A CN 112603959A CN 202011529120 A CN202011529120 A CN 202011529120A CN 112603959 A CN112603959 A CN 112603959A
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particles
parts
drying kettle
temperature
liquid
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贺东兵
马雨涵
吴义兵
周华平
陈莹
张箭
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Hefei China Resources Shenlu Pharmaceutical Co ltd
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Hefei China Resources Shenlu Pharmaceutical Co ltd
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/80Scrophulariaceae (Figwort family)
    • A61K36/804Rehmannia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • AHUMAN NECESSITIES
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/287Chrysanthemum, e.g. daisy
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/35Caprifoliaceae (Honeysuckle family)
    • A61K36/355Lonicera (honeysuckle)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/484Glycyrrhiza (licorice)
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/80Scrophulariaceae (Figwort family)
    • A61K36/808Scrophularia (figwort)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/896Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A61K36/8968Ophiopogon (Lilyturf)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605Excipients; Inactive ingredients
    • A61K9/1629Organic macromolecular compounds
    • A61K9/1652Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/04Drugs for disorders of the respiratory system for throat disorders
    • FMECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F26DRYING
    • F26BDRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
    • F26B11/00Machines or apparatus for drying solid materials or objects with movement which is non-progressive
    • F26B11/12Machines or apparatus for drying solid materials or objects with movement which is non-progressive in stationary drums or other mainly-closed receptacles with moving stirring devices
    • F26B11/14Machines or apparatus for drying solid materials or objects with movement which is non-progressive in stationary drums or other mainly-closed receptacles with moving stirring devices the stirring device moving in a horizontal or slightly-inclined plane
    • FMECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F26DRYING
    • F26BDRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
    • F26B21/00Arrangements or duct systems, e.g. in combination with pallet boxes, for supplying and controlling air or gases for drying solid materials or objects
    • F26B21/001Drying-air generating units, e.g. movable, independent of drying enclosure
    • FMECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F26DRYING
    • F26BDRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
    • F26B21/00Arrangements or duct systems, e.g. in combination with pallet boxes, for supplying and controlling air or gases for drying solid materials or objects
    • F26B21/004Nozzle assemblies; Air knives; Air distributors; Blow boxes
    • FMECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F26DRYING
    • F26BDRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
    • F26B25/00Details of general application not covered by group F26B21/00 or F26B23/00
    • F26B25/04Agitating, stirring, or scraping devices
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/33Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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    • A61K2236/30Extraction of the material
    • A61K2236/39Complex extraction schemes, e.g. fractionation or repeated extraction steps
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50Methods involving additional extraction steps
    • A61K2236/51Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50Methods involving additional extraction steps
    • A61K2236/55Liquid-liquid separation; Phase separation

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Abstract

The invention discloses a preparation process of a Chinese patent medicine for treating chronic pharyngitis, which comprises the following raw materials, by weight, 18-22 parts of radix rehmanniae recen, 2-5 parts of chrysanthemum, 16-23 parts of radix ophiopogonis, 1-3 parts of honeysuckle, 12-15 parts of radix scrophulariae, 1-2 parts of scaphium scaphigerum and 5-7 parts of liquorice. The Chinese patent medicine granules have the advantages of convenient taking, lower sugar content or no sugar content compared with the traditional granules, wider applicable population, low dosage and better help for people who are prohibited from sugar, such as diabetes mellitus and the like.

Description

Preparation process of Chinese patent medicine for treating chronic pharyngitis
Technical Field
The invention relates to the technical field of Chinese patent medicine preparation, in particular to a preparation process of a Chinese patent medicine for treating chronic pharyngitis.
Background
Chronic pharyngitis is a common throat disease and is mainly characterized by throat discomfort, dryness and burning, choking cough and expectoration in clinic. At present, many medicines for treating chronic pharyngitis are added, and some medicines are added with raw materials with high sugar content such as sucrose and syrup, have high sugar content and large dosage and are not suitable for sugar-avoiding people such as diabetes mellitus.
Disclosure of Invention
The invention aims to provide a preparation process of a Chinese patent medicine for treating chronic pharyngitis, which solves the following technical problems: (1) the Chinese patent medicine adopts Chinese herbal medicine components, has the functions of promoting the production of body fluid to quench thirst, cooling and relieving heat, has sufficient treatment effect on chronic pharyngitis such as throat discomfort, dry burning, choking cough and the like, is a granule, is convenient to take, has lower sugar content or no sugar content compared with the traditional granule, has wider applicable population and low dosage, and is better helpful for people who are prohibited from sugar such as diabetes mellitus and the like; (2) the particles are put into a feeding pipe on drying equipment, the resistance belt in the heat dissipation fins continuously heats the air in the drying kettle, the air in the drying kettle is heated, a rotating motor is started, an output shaft of the rotating motor drives a driving bevel gear to rotate, the driving bevel gear is meshed with a driven bevel gear to drive an auger shaft to rotate, the auger shaft rotates to drive an auger blade to rotate, the auger blade continuously transports the particles to a semi-empty space of the drying kettle from the bottom, the auger blade transports the wet particles at the bottom of the drying kettle to the semi-empty space from the bottom, the wet particles fall into the bottom of the drying kettle by the self gravity after being dried by the heat dissipation fins at a short distance, the wet particles are continuously lifted and fall down, the surface of the drying kettle is fully contacted with the drying gas, the drying efficiency is improved, the drying is more sufficient, the fan at the top in the drying kettle is matched with the auger blades, so that the cooling efficiency is higher, and the working efficiency is improved.
The purpose of the invention can be realized by the following technical scheme:
a preparation process of a Chinese patent medicine for treating chronic pharyngitis comprises the following steps:
the method comprises the following steps: weighing 18-22 parts of radix rehmanniae recen, 2-5 parts of chrysanthemum, 16-23 parts of radix ophiopogonis, 1-3 parts of honeysuckle, 12-15 parts of radix scrophulariae, 1-2 parts of boat-fruited sterculia seed and 5-7 parts of liquorice according to parts by weight;
step two: adding weighed honeysuckle, chrysanthemum and boat-fruited sterculia seed into a multifunctional extraction tank, adding 6-10 times of water, soaking at 60-90 ℃ for 30 minutes each time, filtering, carrying out three times according to the method, then pumping hot soaking liquid into a liquid storage tank for later use, placing weighed rehmannia root, dwarf lilyturf tuber, figwort root and liquorice into the multifunctional extraction tank, adding 6-10 times of water, heating to boil, decocting for 1 hour, decocting for 3 times, and pumping extracting liquid into the liquid storage tank for later use;
step three: pumping the hot extract and the extractive solution into a vacuum concentration tank, concentrating under reduced pressure until the relative density is 1.15-1.20Be' to obtain primary concentrated solution;
step four: adding 75% ethanol into the primary concentrated solution, stirring, standing for 24-48 hr, collecting supernatant, recovering ethanol from the supernatant, concentrating the supernatant in a reduced pressure concentration tank under reduced pressure, and concentrating to relative density of 1.22-1.25Be' to obtain extract;
step five: adding the extract into hot purified water, stirring uniformly, filtering to obtain a liquid medicine, placing 1-2 parts of dextrin and 0-1 part of sugar powder into a one-step granulator, setting the temperature of materials in the one-step granulator at 80 ℃, adjusting the flow rate to 25-31, setting the frequency of a fan at 25-35Hz, starting spraying the liquid medicine when the temperature of the materials is more than or equal to 50 ℃, observing the materials to be powdery through a sight glass, wherein the liquid spraying time is 10-20 minutes, setting the temperature of the materials at 45-90 ℃, setting the frequency of the fan at 30-45Hz, setting the flow rate at 27-35 after the liquid spraying is finished, and spraying for 60-90 minutes again to obtain formed particles;
step six: placing the particles into a feeding pipe on drying equipment, sealing the feeding pipe, electrifying resistance belts, continuously heating air in a drying kettle by the resistance belts in radiating fins, starting a rotating motor, driving a driving bevel gear to rotate by a rotating motor output shaft, driving a packing auger shaft to rotate by a driving bevel gear meshed with a driven bevel gear, driving a packing auger blade to rotate by the packing auger shaft, continuously transporting the particles to a drying kettle half-empty from the bottom by the packing auger blade, transporting the wet particles at the bottom of the drying kettle to the half-empty from the bottom by the packing auger blade, drying the particles in a short distance by the radiating fins, falling into the bottom of the drying kettle by self gravity, quickly dehydrating in a short time, opening a control valve, measuring the moisture of the particles by a moisture quick tester, cooling the drying kettle after the moisture of the particles reaches a set value, starting a temperature control motor, driving a fan to rotate, cooling the dried particles in the drying kettle by a fan, simultaneously lifting the dried particles by the auger blades to further cool, discharging hot air through a vent pipe on one side of the drying kettle, opening a control valve after cooling, and discharging the particles from a discharge pipe to obtain the required dried particles;
step seven: and (3) respectively sieving the dried particles by 16-mesh and 60-mesh sieves, putting the particles between 16 meshes and 60 meshes into a two-dimensional motion mixer for mixing for 8-10 minutes, and packaging the particles after mixing is finished to obtain the Chinese patent medicine.
Further, the temperature of the liquid medicine is controlled at 50-85 ℃ when the hot dipping liquid and the extracting liquid are concentrated under reduced pressure in the third step, and the temperature of the liquid medicine is controlled at 50-80 ℃ when the supernate in the fourth step is concentrated under reduced pressure.
Furthermore, the temperature of the hot purified water in the fifth step is 60-100 ℃, and the relative density of the liquid medicine is 10-16 Be'.
Further, in the sixth step, the temperature of the drying kettle is 80-100 ℃, the moisture content of the particles is less than or equal to 6%, the frequency of the fan is 33-40Hz when the drying kettle is cooled, and the temperature of the materials is below 50 ℃.
Further, the drying equipment comprises a drying kettle, an auger shaft is arranged in the drying kettle, the auger shaft penetrates through the bottom of the drying kettle and is sleeved with a driven bevel gear, the driven bevel gear is meshed with and connected with a driving bevel gear, the driving bevel gear is sleeved on an output shaft of a rotating motor, an auger blade is sleeved on the auger shaft and is arranged in the drying kettle, one end of the auger shaft, which is far away from the driven bevel gear, is connected with a heating mechanism, the heating mechanism comprises a heat dissipation fin, a rotating sleeve and a resistance belt, the rotating sleeve is rotatably arranged at the end part of the auger shaft, a plurality of heat dissipation fins with equal radians are fixedly arranged on the rotating sleeve, the resistance belt is arranged in each heat dissipation fin, a plurality of heat dissipation fins are arranged at one side, close to the auger blade, and are provided with a plurality of heat dissipation, temperature-controlled motor output shaft runs through dry cauldron top connection fan, dry cauldron top one side intercommunication has the pan feeding pipe, the outer middle part one side intercommunication of dry cauldron has the breather pipe, it is provided with the thermometer to keep away from breather pipe one side outward for dry cauldron, thermometer and thermocouple electric connection, the thermocouple runs through dry cauldron lateral wall, a plurality of support columns are installed to dry cauldron bottom, dry cauldron bottom intercommunication has the discharging pipe, be provided with the control valve on the discharging pipe, be provided with control panel on the dry cauldron.
The invention has the beneficial effects that:
(1) the Chinese patent medicine adopts Chinese herbal medicine components, has the functions of promoting the production of body fluid to quench thirst, cooling and relieving fever, has sufficient treatment effect on chronic pharyngitis such as throat discomfort, dry burning, choking cough and the like, is a granule, is convenient to take, has lower sugar content or no sugar content compared with the traditional granule, has wider applicable population and low dosage, and is better helpful for people who are prohibited from sugar, such as diabetes mellitus and the like;
(2) the particles are put into a feeding pipe on drying equipment, the resistance belt in the heat dissipation fins continuously heats the air in the drying kettle, the air in the drying kettle is heated, a rotating motor is started, an output shaft of the rotating motor drives a driving bevel gear to rotate, the driving bevel gear is meshed with a driven bevel gear to drive an auger shaft to rotate, the auger shaft rotates to drive an auger blade to rotate, the auger blade continuously transports the particles to a semi-empty space of the drying kettle from the bottom, the auger blade transports the wet particles at the bottom of the drying kettle to the semi-empty space from the bottom, the wet particles fall into the bottom of the drying kettle by the self gravity after being dried by the heat dissipation fins at a short distance, the wet particles are continuously lifted and fall down, the surface of the drying kettle is fully contacted with the drying gas, the drying efficiency is improved, the drying is more sufficient, the fan at the top in the drying kettle is matched with the auger blades, so that the cooling efficiency is higher, and the working efficiency is improved.
Drawings
The invention will be further described with reference to the accompanying drawings.
FIG. 1 is a front view of a drying vessel according to the present invention;
FIG. 2 is a schematic view of the inside structure of a drying vessel according to the present invention;
FIG. 3 is a schematic view of the heating mechanism of the present invention;
fig. 4 is an enlarged view of a in fig. 2.
In the figure: 1. drying the kettle; 2. a feeding pipe; 3. a fan; 4. a packing auger shaft; 5. a screw blade; 6. a heating mechanism; 601. rotating the sleeve; 602. a resistance band; 603. heat dissipation fins; 604. heat dissipation holes; 7. a temperature control motor; 8. rotating the motor; 9. a driven bevel gear; 10. a drive bevel gear; 11. a breather pipe; 12. a support pillar; 13. a thermocouple; 14. a thermometer; 15. and (4) discharging the pipe.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Please refer to FIGS. 1-4
Example 1
A preparation process of a Chinese patent medicine for treating chronic pharyngitis comprises the following steps:
the method comprises the following steps: weighing 18 parts of radix rehmanniae recen, 2 parts of chrysanthemum, 16 parts of radix ophiopogonis, 1 part of honeysuckle, 12 parts of radix scrophulariae, 1 part of boat-fruited sterculia seed and 5 parts of liquorice according to parts by weight;
step two: adding the weighed honeysuckle, the chrysanthemum and the boat-fruited sterculia seed into a multifunctional extraction tank, adding 6 times of water, soaking at 60 ℃ for 30 minutes each time, filtering, carrying out three times according to the method, then pumping hot soaking liquid into a liquid storage tank for later use, placing the weighed rehmannia root, the dwarf lilyturf tuber, the figwort root and the liquorice into the multifunctional extraction tank, adding 6 times of water, heating and boiling, then decocting for 1 hour and 3 times, and pumping extracting liquid into the liquid storage tank for later use;
step three: pumping the hot extract and the extractive solution into a vacuum concentration tank, concentrating under reduced pressure until the relative density is 1.15Be' to obtain primary concentrated solution;
step four: adding 75% ethanol into the primary concentrated solution, stirring, standing for 24 hr, collecting supernatant, recovering ethanol from the supernatant, concentrating the supernatant in a reduced pressure concentration tank under reduced pressure, and concentrating to relative density of 1.22Be' to obtain extract;
step five: adding the extract into hot purified water, uniformly stirring, filtering to obtain a liquid medicine, taking 1 part of dextrin, placing the dextrin into a one-step granulator, setting the temperature of materials in the one-step granulator to 80 ℃, adjusting the flow rate to 25, setting the frequency of a fan to 25Hz, spraying the liquid medicine when the temperature of the materials is more than or equal to 50 ℃, observing the materials to be powdery through a sight glass, wherein the liquid spraying time is 10 minutes, setting the temperature of the materials to 45 ℃ after the liquid spraying is finished, setting the frequency of the fan to 30Hz, setting the flow rate to 27, spraying the liquid medicine again for 60 minutes, observing the flowability of the materials and the forming condition of particles in the liquid spraying process, and obtaining formed particles according to the particle size and the flowability adjustment;
step six: placing the particles into a feeding pipe 2 on drying equipment, sealing the feeding pipe 2, electrifying a resistance belt 602, continuously heating air in a drying kettle 1 by the resistance belt 602 in a radiating fin 603, starting a rotating motor 8, driving a driving bevel gear 10 to rotate by an output shaft of the rotating motor 8, driving a screw shaft 4 to rotate by the driving bevel gear 10 meshed with a driven bevel gear 9, driving a screw blade 5 to rotate by the screw shaft 4, continuously transporting the particles from the bottom to a half space in the drying kettle 1 by the screw blade 5, transporting moist particles at the bottom of the drying kettle 1 from the bottom to the half space by the screw blade 5, drying the particles in a short distance by the radiating fin 603, falling into the bottom of the drying kettle 1 by self gravity, quickly removing moisture in a short time, opening a control valve on a discharging pipe 15, measuring the moisture of the particles by a moisture quick measuring instrument, and cooling the drying kettle 1 when the moisture of the particles reaches a, starting a temperature control motor 7, driving a fan 3 to rotate by an output shaft of the temperature control motor 7, cooling the dried particles in the drying kettle 1 by the fan 3, simultaneously lifting the dried particles by a screw blade 5 to further cool, discharging hot air through a vent pipe 11 at one side of the drying kettle 1, opening a control valve after cooling, and discharging the particles from a discharge pipe 15 to obtain the required dried particles;
step seven: and (3) respectively sieving the dried particles by 16-mesh and 60-mesh sieves, putting the particles between 16 meshes and 60 meshes into a two-dimensional motion mixer for mixing for 8 minutes, and packaging the particles after mixing is finished to obtain the Chinese patent medicine.
Specifically, the temperature of the liquid medicine is controlled at 50 ℃ when the hot-dipping liquid and the extracting solution are concentrated under reduced pressure in the third step, and the temperature of the liquid medicine is controlled at 50 ℃ when the supernate is concentrated under reduced pressure in the fourth step. In the fifth step, the temperature of the hot purified water is 60 ℃, and the relative density of the liquid medicine is 10 Be'. In the sixth step, the temperature of the drying kettle 1 is 80 ℃, the moisture content of the particles is less than or equal to 6 percent, the frequency of the fan 3 is 33Hz when the drying kettle 1 is cooled, and the temperature of the materials is below 50 ℃.
Example 2
A preparation process of a Chinese patent medicine for treating chronic pharyngitis comprises the following steps:
the method comprises the following steps: weighing 22 parts of radix rehmanniae recen, 5 parts of chrysanthemum, 23 parts of radix ophiopogonis, 3 parts of honeysuckle, 15 parts of radix scrophulariae, 2 parts of boat-fruited sterculia seed and 7 parts of liquorice according to parts by weight;
step two: adding the weighed honeysuckle, the chrysanthemum and the boat-fruited sterculia seed into a multifunctional extraction tank, adding 10 times of water, soaking at 90 ℃ for 30 minutes each time, filtering, carrying out three times according to the method, then pumping hot soaking liquid into a liquid storage tank for later use, placing the weighed rehmannia root, the dwarf lilyturf tuber, the figwort root and the liquorice into the multifunctional extraction tank, adding 10 times of water, heating and boiling, then decocting for 1 hour and 3 times, and pumping extracting liquid into the liquid storage tank for later use;
step three: pumping the hot extract and the extractive solution into a vacuum concentration tank, concentrating under reduced pressure until the relative density is 1.20Be' to obtain primary concentrated solution;
step four: adding 75% ethanol into the primary concentrated solution, stirring, standing for 48 hr, collecting supernatant, recovering ethanol from the supernatant, concentrating the supernatant in a reduced pressure concentration tank under reduced pressure, and concentrating to relative density of 1.25Be' to obtain extract;
step five: adding the extract into hot purified water, uniformly stirring, filtering to obtain a liquid medicine, putting 2 parts of dextrin and 1 part of powdered sugar into a one-step granulator, setting the temperature of materials in the one-step granulator to 80 ℃, adjusting the flow rate to 31, setting the frequency of a fan to 35Hz, starting spraying the liquid medicine when the temperature of the materials is not less than 50 ℃, observing the materials to be powdery through a sight glass, spraying the liquid for 20 minutes, setting the temperature of the materials to 90 ℃ after the liquid spraying is finished, setting the frequency of the fan to 45Hz, setting the flow rate to 35, spraying the liquid for 90 minutes again, observing the flowability of the materials and the forming condition of particles in the liquid spraying process, and adjusting parameters according to the particle size and the flowability of the particles in a raw material;
step six is the same as example 1;
step seven: and (3) respectively sieving the dried particles by 16-mesh and 60-mesh sieves, putting the particles between 16 meshes and 60 meshes into a two-dimensional motion mixer for mixing for 10 minutes, and packaging the particles after mixing is finished to obtain the Chinese patent medicine.
Specifically, the temperature of the liquid medicine is controlled at 85 ℃ when the hot-dipping liquid and the extracting solution are concentrated under reduced pressure in the third step, and the temperature of the liquid medicine is controlled at 80 ℃ when the supernate in the fourth step is concentrated under reduced pressure. In the fifth step, the temperature of the hot purified water is 100 ℃, and the relative density of the liquid medicine is 16 Be'. In the sixth step, the temperature of the drying kettle 1 is 100 ℃, the moisture content of the particles is less than or equal to 6 percent, the frequency of the fan 3 is 40Hz when the drying kettle 1 is cooled, and the temperature of the materials is below 50 ℃.
The drying equipment comprises a drying kettle 1, wherein an auger shaft 4 is arranged in the drying kettle 1, the auger shaft 4 penetrates through the bottom of the drying kettle 1 and is sleeved with a driven bevel gear 9, the driven bevel gear 9 is meshed with a driving bevel gear 10, the driving bevel gear 10 is sleeved on an output shaft of a rotating motor 8, an auger blade 5 is sleeved on the auger shaft 4, the auger blade 5 can continuously convey particles to a half-empty space of the drying kettle 1 from the bottom, the auger blade 5 is arranged in the drying kettle 1, one end of the auger shaft 4, far away from the driven bevel gear 9, is connected with a heating mechanism 6, the heating mechanism 6 comprises heat dissipation fins 603, a rotating sleeve 601 and resistance bands 602, the rotating sleeve 601 is rotatably arranged at the end part of the auger shaft 4, a plurality of heat dissipation fins 603 with equal radians are fixedly arranged on the rotating sleeve 601, the plurality of heat dissipation fins 603 are all provided with the, heat dissipation fin 603 is close to auger blade 5 one side and has been seted up a plurality of louvres 604, heat dissipation fin 603 top is provided with fan 3, 1 top in dry cauldron is provided with accuse temperature motor 7, accuse temperature motor 7 output shaft runs through 1 top in dry cauldron and connects fan 3, 1 top one side intercommunication in dry cauldron has pan feeding pipe 2, 1 outer middle part one side intercommunication in dry cauldron has breather pipe 11, 1 outer breather pipe 11 one side of keeping away from of dry cauldron is provided with thermometer 14, thermometer 14 and thermocouple 13 electric connection, thermometer 14 is used for showing 1 interior temperature in the dry cauldron, thermocouple 13 runs through 1 lateral wall in the dry cauldron, a plurality of support columns 12 are installed to 1 bottom in the dry cauldron, 1 bottom intercommunication in dry cauldron has discharging pipe 15, be provided with the control valve on discharging pipe 15, be provided with control panel.
In the description herein, references to the description of "one embodiment," "an example," "a specific example" or the like are intended to mean that a particular feature, structure, material, or characteristic described in connection with the embodiment or example is included in at least one embodiment or example of the invention. In this specification, the schematic representations of the terms used above do not necessarily refer to the same embodiment or example. Furthermore, the particular features, structures, materials, or characteristics described may be combined in any suitable manner in any one or more embodiments or examples.
The foregoing is merely exemplary and illustrative of the present invention and various modifications, additions and substitutions may be made by those skilled in the art to the specific embodiments described without departing from the scope of the invention as defined in the following claims.

Claims (5)

1. A preparation process of a Chinese patent medicine for treating chronic pharyngitis is characterized by comprising the following steps:
the method comprises the following steps: weighing 18-22 parts of radix rehmanniae recen, 2-5 parts of chrysanthemum, 16-23 parts of radix ophiopogonis, 1-3 parts of honeysuckle, 12-15 parts of radix scrophulariae, 1-2 parts of boat-fruited sterculia seed and 5-7 parts of liquorice according to parts by weight;
step two: adding weighed honeysuckle, chrysanthemum and boat-fruited sterculia seed into a multifunctional extraction tank, adding 6-10 times of water, soaking at 60-90 ℃ for 30 minutes each time, filtering, carrying out three times according to the method, then pumping hot soaking liquid into a liquid storage tank for later use, placing weighed rehmannia root, dwarf lilyturf tuber, figwort root and liquorice into the multifunctional extraction tank, adding 6-10 times of water, heating to boil, decocting for 1 hour, decocting for 3 times, and pumping extracting liquid into the liquid storage tank for later use;
step three: pumping the hot extract and the extractive solution into a vacuum concentration tank, concentrating under reduced pressure until the relative density is 1.15-1.20Be' to obtain primary concentrated solution;
step four: adding 75% ethanol into the primary concentrated solution, stirring, standing for 24-48 hr, collecting supernatant, recovering ethanol from the supernatant, concentrating the supernatant in a reduced pressure concentration tank under reduced pressure, and concentrating to relative density of 1.22-1.25Be' to obtain extract;
step five: adding the extract into hot purified water, stirring uniformly, filtering to obtain a liquid medicine, placing 1-2 parts of dextrin and 0-1 part of sugar powder into a one-step granulator, setting the temperature of materials in the one-step granulator at 80 ℃, adjusting the flow rate to 25-31, setting the frequency of a fan at 25-35Hz, starting spraying the liquid medicine when the temperature of the materials is more than or equal to 50 ℃, observing the materials to be powdery through a sight glass, wherein the liquid spraying time is 10-20 minutes, setting the temperature of the materials at 45-90 ℃, setting the frequency of the fan at 30-45Hz, setting the flow rate at 27-35 after the liquid spraying is finished, and spraying for 60-90 minutes again to obtain formed particles;
step six: placing the particles into a feeding pipe on drying equipment, sealing the feeding pipe, electrifying resistance belts, continuously heating air in a drying kettle by the resistance belts in radiating fins, starting a rotating motor, driving a driving bevel gear to rotate by a rotating motor output shaft, driving a packing auger shaft to rotate by a driving bevel gear meshed with a driven bevel gear, driving a packing auger blade to rotate by the packing auger shaft, continuously transporting the particles to a drying kettle half-empty from the bottom by the packing auger blade, transporting the wet particles at the bottom of the drying kettle to the half-empty from the bottom by the packing auger blade, drying the particles in a short distance by the radiating fins, falling into the bottom of the drying kettle by self gravity, quickly dehydrating in a short time, opening a control valve, measuring the moisture of the particles by a moisture quick tester, cooling the drying kettle after the moisture of the particles reaches a set value, starting a temperature control motor, driving a fan to rotate, cooling the dried particles in the drying kettle by a fan, simultaneously lifting the dried particles by the auger blades to further cool, discharging hot air through a vent pipe on one side of the drying kettle, opening a control valve after cooling, and discharging the particles from a discharge pipe to obtain the required dried particles;
step seven: and (3) respectively sieving the dried particles by 16-mesh and 60-mesh sieves, putting the particles between 16 meshes and 60 meshes into a two-dimensional motion mixer for mixing for 8-10 minutes, and packaging the particles after mixing is finished to obtain the Chinese patent medicine.
2. The preparation process of the Chinese patent medicine for treating chronic pharyngitis according to claim 1, wherein the temperature of the liquid medicine is controlled to be 50-85 ℃ when the hot-dipping liquid and the extracting liquid in the third step are concentrated under reduced pressure, and the temperature of the liquid medicine is controlled to be 50-80 ℃ when the supernate in the fourth step is concentrated under reduced pressure.
3. The preparation process of the Chinese patent medicine for treating chronic pharyngitis according to claim 1, wherein the temperature of the hot purified water in the fifth step is 60-100 ℃, and the relative density of the liquid medicine is 10-16 Be'.
4. The preparation process of a Chinese patent medicine for treating chronic pharyngitis according to claim 1, wherein in the sixth step, the temperature in the drying kettle is 80-100 ℃, the moisture content of the granules is less than or equal to 6%, the frequency of the fan is 33-40Hz when the drying kettle is cooled, and the temperature of the material is below 50 ℃.
5. The preparation process of a Chinese patent drug for treating chronic pharyngitis according to claim 1, wherein the drying equipment comprises a drying kettle, an auger shaft is arranged in the drying kettle, the auger shaft is sleeved with a driven bevel gear through the bottom of the drying kettle, the driven bevel gear is meshed with and connected with a driving bevel gear, the driving bevel gear is sleeved on an output shaft of a rotating motor, an auger blade is sleeved on the auger shaft, the auger blade is arranged in the drying kettle, one end of the auger shaft, which is far away from the driven bevel gear, is connected with a heating mechanism, the heating mechanism comprises a heat dissipation fin, a rotating sleeve and a resistance belt, the rotating sleeve is rotatably arranged at the end part of the auger shaft, the rotating sleeve is fixedly provided with a plurality of heat dissipation fins with equal radians, a plurality of resistance belts are arranged in the heat dissipation fins, a plurality of heat dissipation holes are formed at, the heat dissipation wing top is provided with the fan, dry cauldron top is provided with accuse temperature motor, accuse temperature motor output shaft runs through dry cauldron top connection fan, dry cauldron top one side intercommunication has the pan feeding pipe, the outer middle part one side intercommunication of dry cauldron has the breather pipe, it is provided with the thermometer to keep away from breather pipe one side outward for dry cauldron, thermometer and thermocouple electric connection, the thermocouple runs through dry cauldron lateral wall, a plurality of support columns are installed to dry cauldron bottom, dry cauldron bottom intercommunication has the discharging pipe, be provided with the control valve on the discharging pipe, be provided with control panel on the dry cauldron.
CN202011529120.2A 2020-12-22 2020-12-22 Preparation process of Chinese patent medicine for treating chronic pharyngitis Pending CN112603959A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116222192A (en) * 2022-12-08 2023-06-06 亳州市宏宇中药饮片有限公司 Medicated leaven processing technology and processing equipment

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN2476775Y (en) * 2001-04-10 2002-02-13 陈金贵 Rotary drying machine
CN1387890A (en) * 2002-06-15 2003-01-01 合肥神鹿双鹤药业有限责任公司 Chinese medicine granule for treating chronic pharyngitis and its prepn process
CN106959001A (en) * 2017-05-30 2017-07-18 尹国祥 A kind of auger mechanism for material heated-air drying
CN209588644U (en) * 2019-03-05 2019-11-05 张掖市恒利中药材加工有限公司 A kind of Chinese medicine slice continuous dryer

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN2476775Y (en) * 2001-04-10 2002-02-13 陈金贵 Rotary drying machine
CN1387890A (en) * 2002-06-15 2003-01-01 合肥神鹿双鹤药业有限责任公司 Chinese medicine granule for treating chronic pharyngitis and its prepn process
CN106959001A (en) * 2017-05-30 2017-07-18 尹国祥 A kind of auger mechanism for material heated-air drying
CN209588644U (en) * 2019-03-05 2019-11-05 张掖市恒利中药材加工有限公司 A kind of Chinese medicine slice continuous dryer

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116222192A (en) * 2022-12-08 2023-06-06 亳州市宏宇中药饮片有限公司 Medicated leaven processing technology and processing equipment
CN116222192B (en) * 2022-12-08 2024-04-26 亳州市宏宇中药饮片有限公司 Medicated leaven processing technology and processing equipment

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Application publication date: 20210406