CN1126038A

CN1126038A - Fat reducing chewing gum

Info

Publication number: CN1126038A
Application number: CN 95109312
Authority: CN
Inventors: 吴宏伟; 杜秋梅; 苏柏青
Original assignee: Individual
Current assignee: Individual
Priority date: 1995-08-07
Filing date: 1995-08-07
Publication date: 1996-07-10
Anticipated expiration: 2015-08-07
Also published as: CN1045246C

Abstract

The weight-losing chewing gum is made from 13 Chinese-medicinal components such as raw haw, scabish, raw fleece flower root, white chrysanthemum flower, etc, defatted milk powder or whey powder, gel, proteoglycan, pepper powder, extracted liquid of mint in anhydrous alcohole, essence, hydroxypropyl cellulose and hydroxypropyl methylcellulose, and features its medical functions of losing weight, removing foul breath, and preventing and curing hyperlipemia, atherosclerosis, fatty liver and diabetes.

Description

Fat reducing chewing gum

The present invention relates to a kind of fat reducing chewing gum.

At present, China's confection market confection is of a great variety, and the type class differs, its composition is not quite similar, and as plain edition, suckle newborn type, coffee type, cold-type yellow (clear) etc., sees only sugar and sugar from the combined ingredient of confection, only confection and confection also have some chewing gum, but it have only the function of antihalitosis.

The object of the present invention is to provide a kind of fat reducing chewing gum, not only have the antihalitosis effect, also have weight losing function.

Technical solution of the present invention to achieve these goals is achieved by the following technical solution: this fat reducing chewing gum is by Chinese herbal medicine, defatted milk powder or whey powder, gel, protein sugar, Fructus Piperis powder, the immersion of Herba Menthae dehydrated alcohol, essence, hydroxypropyl cellulose and hydroxypropyl emthylcellulose mix, the content of each composition is 10～20 parts of Chinese herbal medicine, 60～80 parts of defatted milk powder or whey powders, 20～30 parts of gels, 0.5～1 part of protein sugar, 0.1～0.3 part of Fructus Piperis powder, 0.1～0.2 part of Herba Menthae dehydrated alcohol immersion, 0.024～0.04 part in essence, 5～10 parts of hydroxypropyl celluloses and hydroxypropyl emthylcellulose are an amount of, and wherein Chinese herbal medicine is by 3～5 parts of Fructus Crataegi, 4～6 parts of Largeleaf Gymnema, 3～5 parts of Radix Oenotherae erythrosepalaes, 3～5 parts of Radix Polygoni Multifloris, 1.5～3 parts of Flos Chrysanthemis, 1.5～3 parts of Herba Lysimachiae foenum-graeci, 3～5 parts of green tea, 1～2 part of the Rhizoma Atractylodis Macrocephalae, 3～5 parts of Fructus Lycii, 1～2 part of mentha leave, 2～4 parts of Folium Stevlae Rebaudianae, 3～5 parts of SEMEN CARTHAMIs, 3～5 parts of institutes of Radix Glycyrrhizae combine.

The production technology of product of the present invention is as follows:

1, Chinese herbal medicine such as Fructus Crataegi, Largeleaf Gymnema, Radix Oenotherae erythrosepalae, Radix Polygoni Multiflori, Flos Chrysanthemi, Herba Lysimachiae foenum-graeci, green tea, Folium Stevlae Rebaudianae, the Rhizoma Atractylodis Macrocephalae, SEMEN CARTHAMI, Fructus Lycii, mentha leave, Radix Glycyrrhizae is heated after the water logging bubble 10～12 hours, under 90～100 ℃ of temperature, refluxed 2 hours, filter and remove residue, make concentrated solution, add hydroxypropyl cellulose adsorbate mix homogeneously then.

2, gel is soaked in 84～96 ℃ water-bath, thermosol is at 70 ℃, heat-retaining condition adds the mixed liquor mix homogeneously that Chinese herbal medicine concentrated solution and adsorbate make down, adds defatted milk powder or whey powder and protein sugar mix homogeneously then, is cooled to 30～40 ℃ of extrusion modlings.

3, spray Fructus Piperis powder, Herba Menthae anhydrous alcohol solution and essence after the molding.

4, get final product with carrying out the polishing processing behind the hydroxypropyl emthylcellulose coating.

Weight losing function mechanism of the present invention is to catch human body cause illness's main cause, by adjusting human body transporting and transforming function of the spleen and stomach absorption process, blocking-up lipogenesis approach, increase body material generation penetrate with body fluid for the firing rate degree, decompose the superabundant fats of piling up in the fat storehouse, thereby reach the fat-reducing purpose, simultaneously, by replenishing multiple element of body and nutrient substance, reach allaying tiredness to the greatest extent, the effect of refreshment brain-strengthening because of this product has blood fat reducing, blood viscosity lowering, blood sugar reducing function, is equally applicable to atherosclerosis, hyperlipemia, fatty liver, diabetes etc.

Rhizoma Atractylodis Macrocephalae invigorating the spleen and replenishing QI in the medicinal herb components, dampness diuretic, the secretion of promotion the intestines and stomach, blood sugar lowering protects the liver, and prevents that liver glycogen from reducing; The Fructus Crataegi promoting digestion and invigorating the stomach, blood circulation promoting and blood stasis dispelling, contained lipase can reduce fat, and suppresses lipid material at intrahepatic deposition, is one of main component of this medicine, and is effective to hyperlipemia, severe obesity; Radix Polygoni Multiflori invigorating the liver and kidney, benefiting essence-blood, the relieving constipation detoxifcation can stop cholesterol at intrahepatic deposition, alleviates atherosclerosis and forms, and hypoglycemic activity is arranged, and contained lecithin is to constitute the particularly main component of brains of nervous tissue, thereby the merit of nourishing the brain and improving intelligence is arranged; The Fructus Lycii nourishing essence-blood, blood sugar lowering can suppress fat at intrahepatic deposition, promotes liver cell regeneration, cholesterol reducing, tonification human bodies such as contained multivitamin B, C; Radix Oenotherae erythrosepalae can defying age, preventing thrombosis, blood fat reducing and prevent and treat atherosclerosis, and contained gamma-linolenic acid is the topmost unsaturated acids of lipid metabolism of regulating human body, also is the precursor source of prostaglandin in the body; Gymnemic acid can be suppressed at and absorb glucose in the small intestinal, suppresses blood glucose and rises, and can prevent and treat diabetes and obesity, to the glucosan of pathogenic bacteria of decayed tooth is synthetic inhibitory action is arranged, and is effective to preventing and treating dental caries; The Flos Chrysanthemi suppressing the hyperactive liver makes eye bright, and coronary artery dilator increases coronary flow, and the blood fat reducing effect is arranged; The SEMEN CARTHAMI promoting blood circulation and detoxication, contained fatty oil can reduce blood cholesterol and hyperlipidemia, and softening and blood vessel dilating increases blood circulation, steatolysis conversion and energy volatilization process.

To the internal organs of obesity location, start with by liver,spleen,kidney from the traditional Chinese medical science for above medicine, liver and kidney tonifying, and the spleen invigorating dehumidifying, dissipating phlegm and removing blood stasis just reaches the purpose of lowering blood-fat and reducing weight, blood sugar lowering Fructus Alpiniae Oxyphyllae by substance metabolism.

But select the mentha leave wind-dispelling heat-dissipating for use, the clear sharp head keeps away dirty detoxifcation, and people's implication perfume (or spice) is clean, refrigerant tasty and refreshing in addition; The green tea refresh oneself, relieving thirst and restlessness refreshment brain-strengthening is eliminated fat good Somnolence, blood fat reducing and promote systemic blood circulation, and can antibacterial counteract oral malodour; Herba Lysimachiae foenum-graeci is kept away foul, and it is cold to dispel the wind, and the gas suffering of its fragrance reaches on loosing, and dispels halitosis; The Folium Stevlae Rebaudianae sweet taste is pure, and contained stevioside is beneficial to blood sugar lowering and fat-reducing, and contained vitamin etc. can be made nutritional supplementation, also can be used as correctives; The Radix Glycyrrhizae coordinating the actions of various ingredients in a prescription relaxes the property of medicine, heat-clearing and toxic substances removing, and effective ingredient such as contained glycyrrhizin can reduce blood cholesterol content, stop progression of atherosclerosis; The defatted milk powder fat content is low, and anti-preservation is difficult for oxidation deterioration; The protein sugar tissue is fine and smooth, and is loose porous, and inlet is softening easily, and is flexible when chewing; Gel can be made thickening agent; Hydroxypropyl emthylcellulose is as coating.

Product of the present invention has the following advantages:

1, raw material adopts natural medicinal plant, draws materials conveniently, and is cheap, has no side effect, and carries and taking convenience.

2, prescription rationally, participate in metabolism directly, regulate taste and absorb the fortuneization process, reduce glucose absorbtivity in small intestinal, suppressing blood glucose value rises, promote the volatilization of excess energy in the body, cut down the synthetic of the interior three big fat storehouses of body, the three big approach that blocking-up lipid forms in vivo and in vitro, thereby lipid is piled up in the minimizing body, can prevent and treat obesity, and can prevent and treat hyperlipemia, diseases such as atherosclerosis, fatty liver and diabetes.

3, this product also have the refreshment brain-strengthening, inspire enthusiasm, allaying tiredness and clearing away heat-damp and promoting diuresis function.

4, this product does not contain human body indigestibility, excretory gummy substrate, be convenient to suck, and the taste fragrance, old children is all suitable.

5, this product can be removed various halitosis, and deodorizing effect is higher 10～20 times than commercially available chewing gum, and effective to preventing and treating dental caries.

Further specify technical solution of the present invention with clinical trial data in conjunction with the embodiments.

One, embodiment

1, taking by weighing Fructus Crataegi 40g, Largeleaf Gymnema 50g, Radix Oenotherae erythrosepalae 40g, Radix Polygoni Multiflori 40g, Flos Chrysanthemi 20g, Herba Lysimachiae foenum-graeci 20g, green tea 40g, Rhizoma Atractylodis Macrocephalae 20g, Fructus Lycii 40g, mentha leave 15g, Folium Stevlae Rebaudianae 30g, SEMEN CARTHAMI 30g, Radix Glycyrrhizae 40g heats after the water logging bubble 10～12 hours, under 90～100 ℃ of temperature, refluxed 2 hours, filter and remove residue, make concentrated solution, add 50g hydroxypropyl cellulose adsorbate mix homogeneously then.

2,400g pectin and edible gel 200g are put into water-bath, in 84～96 ℃ water-bath, soak, at 70 ℃ of hot melts, and heat-retaining condition adds the mixed liquor mix homogeneously that said herbal medicine concentrated solution and adsorbate make down, add defatted milk powder 1000g and whey powder 275g and protein sugar 10g mix homogeneously then, be cooled to 30～40 ℃ of extrusion modlings.

3, spraying 0.6g Fructus Piperis powder, 0.5g Herba Menthae anhydrous alcohol solution and 0.15g essence after the molding.

4, get final product with carrying out the polishing processing behind an amount of hydroxypropyl emthylcellulose coating.

Two, clinical trial data

Extremely the present time more than 3 years is treated simple obesity patient 1957 examples altogether from February, 1992 to use this chewing gum, wherein male's 856 examples, women's 1101 examples, merge hyperlipemia 237 examples, male's 42 examples, women's 195 examples, fatty liver 57 examples, male 7 examples, women 50 examples, atherosclerotic's 88 examples, man's 30 examples, women 58 examples, complication with diabetes person 11 examples, male 2 examples, women 9 examples, for further investigating the prevention effect of this confection, randomly draw simple obesity 80 examples, be divided into two groups of each 40 examples, compare experimental observation.

Control group (hereinafter to be referred as A group) is totally 40 examples, wherein male's 18 examples, women's 22 examples, and the range of age was at 25-50 years old, and the mean age was at 28.2 years old.

Matched group (hereinafter to be referred as B group) is totally 40 examples, wherein male's 11 examples, women's 29 examples, and the range of age is at 23-51 years old, and the mean age is at 32.8 years old, there was no significant difference between two groups of mean aves (P＞0.05).

In the control group, slight fat 12 examples, average overweight 5-10kg, fat 19 examples of moderate, average overweight 15-20kg, fat 9 examples of severe are more than average overweight 25-30kg, matched group is slight, moderate, fat each 15,18,7 example of severe, two groups of overweight situation no significant differences (P＞0.05).

Companion's fatty liver person 2 examples, hyperlipemia 8 examples, arteriosclerosis 9 examples, diabetes 3 examples in the control group.

Matched group is respectively between 3,7,8,2, two groups with disease no significant difference (P＞0.05) in proper order by control group disease.

Dosage and method:

The A group: use this chewing gum, every heavy 10g, content of dispersion 2.5-2.7g, each four, day clothes three times, take half an hour ante cibum;

The B group: use Radix Et Rhizoma Rhei capsulae, every 0.5g, each two, day clothes three times all can before and after the diet.

Observation index and assessment method:

1,30 days course of treatment, weight loss 2-3kg is a produce effects, and decline 1.5kg is effectively, and the 1-0kg that descends is invalid.

2, according to human body fat storehouse distribution, can measure chest measurement, waistline and abdominal circumference, hip circumference downscaling etc., reduce obvious person and be produce effects more than 10 centimeters, 3-5 centimeters is effectively, is invalid below 3 centimeters.

3, the following symptom person of being clearly better is a produce effects, slightly improvement person is effective, symptom not alleviator is invalid, its symptom is: drowsiness, hyperhidrosis, breathe hard, moving then dyspnea with rapid and short breath, dizziness, constipation, weak, lazy moving etc., other complication such as hyperlipemia are referring to chemically examining blood fat list, fatty liver with reference to B ultrasonic, cerebral arteriosclerosis is referring to examination of ocular fundus, blood fat list, and diabetes are referring to blood glucose, glucose in urine report.This can be for referencial use when efficacy evaluation.

Observed result sees the following form: organize the effective routine digital display of total invalid routine number and imitate the total effective routine number of routine number

Example Shuo (%) (%) (%) (%) A 40 4 (10) 23 (57.5) 13 (32.5) 36 (90) B 40 10 (25) 24 (60) 6 (15) 30 (75) P＜0.01＞0.05＜0.01＜0.01

Find out that from last table A group produce effects number is higher than the B group, invalid number A group is less than the B group, and obvious difference, total effective rate A group be apparently higher than the B group, and there was no significant difference between two groups of effective percentage, from total prevention effect, the fat-reducing effect of this chewing gum obviously is better than the Radix Et Rhizoma Rhei capsulae group.

The afterreaction of taking medicine is observed:

A group: do not see untoward reaction, and above-mentioned conscious clinical symptoms takes a turn for the better or disappears,, constipation drowsiness, weak etc. as hyperhidrosis, because goods exist with the form of sugar, pure, the comfortable taste of sweet taste is very easily accepted by people.

The B group: exist and pay reaction, the different diarrhoea phenomenon of degree is arranged, wherein 8 people have slight gastralgia or discomfort, and after the drug withdrawal, transference cure need not special handling.

Discuss and analyze:

Medicinal monotaste plant Radix Et Rhizoma Rhei, it is the common drug of preventing and treating simple obesity in recent years, domestic once had many data and paper to report, in this clinical observation comparative drug as product of the present invention, be highly significant, Radix Et Rhizoma Rhei have the good reputation of " general ", but it is fierce by its property of medicine, strong excessively to body fluid consumption, the effect of paying is bigger, and by careful usefulness.

And product of the present invention, just because of rigorous, the medication science of prescription, dosage form novelty, do not have the effect of paying and extremely the people parent look at, the control simple obesity, must start with from the origin that causes a disease, entangle its depart from, but heresy set upright, lowering blood-fat and reducing weight, subtract and do not wane, subtract and do not rush down, subtract and the final purpose of not stifled three elements thereby reach.

Claims

1, a kind of fat reducing chewing gum, it is characterized in that: by Chinese herbal medicine, defatted milk powder or whey powder, gel, protein sugar, Fructus Piperis powder, the immersion of Herba Menthae dehydrated alcohol, essence, hydroxypropyl cellulose and hydroxypropyl emthylcellulose mix and make, the content of each composition is 10～20 parts of Chinese herbal medicine, 60～80 parts of defatted milk powder or whey powders, 20～30 parts of gels, 0.5～1 part of protein sugar, 0.1～0.3 part of Fructus Piperis powder, 0.1～0.2 part of Herba Menthae dehydrated alcohol immersion, 0.024～0.04 part in essence, 5～10 parts of hydroxypropyl celluloses and hydroxypropyl emthylcellulose are an amount of, and wherein Chinese herbal medicine is by 3～5 parts of Fructus Crataegi, 4～6 parts of Largeleaf Gymnema, 3～5 parts of Radix Oenotherae erythrosepalaes, 3～5 parts of Radix Polygoni Multifloris, 1.5～3 parts of Flos Chrysanthemis, 1.5～3 parts of Herba Lysimachiae foenum-graeci, 3～5 parts of green tea, 1～2 part of the Rhizoma Atractylodis Macrocephalae, 3～5 parts of Fructus Lycii, 1～2 part of mentha leave, 2～4 parts of Folium Stevlae Rebaudianae, 3～5 parts of SEMEN CARTHAMIs, 3～5 parts of institutes of Radix Glycyrrhizae combine.