CN112601556A - 含有芳硝基的连接子、含连接子的抗体偶联药物及连接子的用途 - Google Patents

含有芳硝基的连接子、含连接子的抗体偶联药物及连接子的用途 Download PDF

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CN112601556A
CN112601556A CN201980055709.2A CN201980055709A CN112601556A CN 112601556 A CN112601556 A CN 112601556A CN 201980055709 A CN201980055709 A CN 201980055709A CN 112601556 A CN112601556 A CN 112601556A
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formula
cancer
compound
methyl
hydrogen
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CN112601556B (zh
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周辛波
王彦明
李松
钟武
樊士勇
肖典
肖军海
郑志兵
李行舟
谢云德
曹瑞源
王晓奎
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Institute of Pharmacology and Toxicology of AMMS
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Abstract

一种式I所示的含有芳硝基的连接子，还涉及含有所述连接子的抗体偶联药物，还涉及所述连接子的用途，还涉及包含所述抗体偶联药物的药物组合物，还涉及这些抗体偶联药物用于治疗和/或预防疾病的用途。

Description

PCT国内申请，说明书已公开。

Claims (21)

  1. PCT国内申请，权利要求书已公开。
CN201980055709.2A 2018-08-30 2019-08-28 含有芳硝基的连接子、含连接子的抗体偶联药物及连接子的用途 Active CN112601556B (zh)

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CN201811002559.2A CN110872339A (zh) 2018-08-30 2018-08-30 含有芳硝基的连接子、含连接子的抗体偶联药物及连接子的用途
PCT/CN2019/103053 WO2020043129A1 (zh) 2018-08-30 2019-08-28 含有芳硝基的连接子、含连接子的抗体偶联药物及连接子的用途

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CN114605367B (zh) * 2020-12-03 2023-06-27 中国人民解放军军事科学院军事医学研究院 含香豆素的连接子及含该连接子的抗体偶联药物
CN115215780B (zh) * 2022-04-22 2023-08-08 上海格苓凯生物科技有限公司 一种利用n,n-二琥珀酰亚胺基碳酸酯制备异双功能交联剂smcc的方法

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WO2009151687A2 (en) * 2008-03-12 2009-12-17 The Regents Of The University Of Michigan Dendrimer conjugates
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CN107417672A (zh) * 2017-04-12 2017-12-01 华东师范大学 一种基于2,2‑二甲基‑3‑（2‑硝基咪唑基）丙酸的低氧激活前药
WO2017214301A1 (en) * 2016-06-08 2017-12-14 Abbvie Inc. Anti-egfr antibody drug conjugates
CN107789630A (zh) * 2016-10-08 2018-03-13 四川百利药业有限责任公司 半胱氨酸改造的抗体‑毒素偶联物及其制备方法

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WO2009151687A2 (en) * 2008-03-12 2009-12-17 The Regents Of The University Of Michigan Dendrimer conjugates
CN106661123A (zh) * 2014-06-20 2017-05-10 荷商台医(有限合伙)公司 抗‑cd22抗体‑药物缀合物及其使用方法
WO2016094505A1 (en) * 2014-12-09 2016-06-16 Abbvie Inc. Antibody drug conjugates with cell permeable bcl-xl inhibitors
WO2017214301A1 (en) * 2016-06-08 2017-12-14 Abbvie Inc. Anti-egfr antibody drug conjugates
CN107789630A (zh) * 2016-10-08 2018-03-13 四川百利药业有限责任公司 半胱氨酸改造的抗体‑毒素偶联物及其制备方法
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