CN112601513B - 治疗眼部疾病的药物 - Google Patents

治疗眼部疾病的药物 Download PDF

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Publication number
CN112601513B
CN112601513B CN201980037118.2A CN201980037118A CN112601513B CN 112601513 B CN112601513 B CN 112601513B CN 201980037118 A CN201980037118 A CN 201980037118A CN 112601513 B CN112601513 B CN 112601513B
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cycloalkyl
halo
alkyl
group
hydrogen
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Chinese (zh)
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CN112601513A (zh
Inventor
苏里亚·坎塔·德
G·斯里达尔·普拉萨德
马歇尔·克拉克·彼得曼
伯纳德·科林斯
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Praxair Pharmaceutical Co
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Praxair Pharmaceutical Co
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/661—Phosphorus acids or esters thereof not having P—C bonds, e.g. fosfosal, dichlorvos, malathion or mevinphos
    • A61K31/6615—Compounds having two or more esterified phosphorus acid groups, e.g. inositol triphosphate, phytic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4741—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having oxygen as a ring hetero atom, e.g. tubocuraran derivatives, noscapine, bicuculline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/10—Ophthalmic agents for accommodation disorders, e.g. myopia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/12—Ophthalmic agents for cataracts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Ophthalmology & Optometry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN201980037118.2A 2018-04-05 2019-04-05 治疗眼部疾病的药物 Active CN112601513B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201862653249P 2018-04-05 2018-04-05
US62/653,249 2018-04-05
US201862694729P 2018-07-06 2018-07-06
US62/694,729 2018-07-06
PCT/US2019/026112 WO2019195761A2 (en) 2018-04-05 2019-04-05 Pharmacological agents for treating ocular diseases

Publications (2)

Publication Number Publication Date
CN112601513A CN112601513A (zh) 2021-04-02
CN112601513B true CN112601513B (zh) 2023-12-22

Family

ID=68101528

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201980037118.2A Active CN112601513B (zh) 2018-04-05 2019-04-05 治疗眼部疾病的药物

Country Status (6)

Country Link
US (1) US11872236B2 (https=)
JP (1) JP7532259B2 (https=)
CN (1) CN112601513B (https=)
BR (1) BR112020020351A2 (https=)
MX (1) MX2020010502A (https=)
WO (1) WO2019195761A2 (https=)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN120097859A (zh) * 2019-02-19 2025-06-06 加利福尼亚大学董事会 Nurr1受体调节剂
EP3976017A4 (en) * 2019-05-31 2023-06-14 Plex Pharmaceuticals, Inc. PHARMACOLOGICAL SUBSTANCES FOR THE TREATMENT OF PROTEIN AGGREGATION DISEASES OF THE EYE
WO2021086834A1 (en) * 2019-10-28 2021-05-06 Kebotix, Inc. Electronic control of transmittance of visible and near-infrared radiation
WO2022098847A1 (en) * 2020-11-04 2022-05-12 Corino Therapeutics, Inc. Tolcapone analogs and methods of use
CN116963727A (zh) * 2020-11-13 2023-10-27 普莱克斯医药公司 用于治疗眼部病症的药剂
JP2023549533A (ja) * 2020-11-13 2023-11-27 プレックス ファーマスーティカルズ，インク 眼の状態を処置するための薬理剤
US20250019352A1 (en) * 2021-06-29 2025-01-16 Plex Pharmaceuticals, Inc. Pharmacological agents for treating ophthalmic diseases
GB202204798D0 (en) 2022-04-01 2022-05-18 Bial Portela & Ca Sa Prodrugs of opicapone
WO2024123100A1 (ko) * 2022-12-09 2024-06-13 경희대학교 산학협력단 신규 아밀로이드-베타 응집체 분해제와 이를 이용한 뇌 표적화 약물 전달 시스템

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5476875A (en) * 1986-03-11 1995-12-19 Hoffman-La Roche Inc. Catechol derivatives
CN1188755A (zh) * 1997-01-22 1998-07-29 弗·哈夫曼-拉罗切有限公司 二苯酮衍生物的制备方法
WO2014147464A2 (en) * 2013-03-20 2014-09-25 Ra Chem Pharma Limited Novel process for the preparation of tolcapone
CN106163548A (zh) * 2014-02-08 2016-11-23 健泰科生物技术公司 治疗阿尔茨海默氏病的方法
CN107206009A (zh) * 2014-08-22 2017-09-26 广州康睿生物医药科技股份有限公司 用于治疗视觉障碍的组合物和方法
WO2022104383A1 (en) * 2020-11-13 2022-05-19 Plex Pharmaceuticals, Inc. Pharmacological agents for treating conditions of the eye
WO2023278464A1 (en) * 2021-06-28 2023-01-05 Plex Pharmaceuticals, Inc. Pharmacological agents for preventing and treating cataracts and presbyopia eye diseases

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK175069B1 (da) 1986-03-11 2004-05-24 Hoffmann La Roche Pyrocatecholderivater
JPH1036257A (ja) * 1996-05-22 1998-02-10 Kikkoman Corp メイラード反応阻害剤
JP2000256259A (ja) * 1999-03-11 2000-09-19 Nippon Zoki Pharmaceut Co Ltd メイラード反応阻害剤
US8299079B2 (en) 2009-05-22 2012-10-30 Kaufman Herbert E Preparations and methods for ameliorating or reducing presbyopia
WO2011047412A1 (en) * 2009-10-22 2011-04-28 The Heart Research Institute Ltd Tyrosine and l-dopa for reducing l-dopa incorporation into proteins
WO2011140333A1 (en) * 2010-05-07 2011-11-10 The Board Of Trustees Of The Leland Stanford Junior University Identification of stabilizers of multimeric proteins
WO2015095257A2 (en) * 2013-12-18 2015-06-25 Emory University Managing visual dysfunction or loss of vision for diabetic subjects
WO2017039525A1 (en) 2015-09-04 2017-03-09 Lobsor Pharmaceuticals Aktiebolag Method of treating a dopamine related disorder in a subject by administering levodopa, in combination with a dopamine decarboxylase inhibitor and a catechol-o-methyltransferase inhibitor

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5476875A (en) * 1986-03-11 1995-12-19 Hoffman-La Roche Inc. Catechol derivatives
CN1188755A (zh) * 1997-01-22 1998-07-29 弗·哈夫曼-拉罗切有限公司 二苯酮衍生物的制备方法
WO2014147464A2 (en) * 2013-03-20 2014-09-25 Ra Chem Pharma Limited Novel process for the preparation of tolcapone
CN106163548A (zh) * 2014-02-08 2016-11-23 健泰科生物技术公司 治疗阿尔茨海默氏病的方法
CN107206009A (zh) * 2014-08-22 2017-09-26 广州康睿生物医药科技股份有限公司 用于治疗视觉障碍的组合物和方法
WO2022104383A1 (en) * 2020-11-13 2022-05-19 Plex Pharmaceuticals, Inc. Pharmacological agents for treating conditions of the eye
WO2023278464A1 (en) * 2021-06-28 2023-01-05 Plex Pharmaceuticals, Inc. Pharmacological agents for preventing and treating cataracts and presbyopia eye diseases

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
Administration of antioxidant compounds affects the lens chaperone activity and prevents the onset of cataracts;Yosuke Nakazawa等;《Biomed Pharmacother》;第95卷;137-143 *
Pharmacological restoration of transparency in cataract;L. Makley等;《Acta Ophthalmologica》;20161031;第94卷(第S256期);摘要 *
Repositioning tolcapone as a potent inhibitor of transthyretin amyloidogenesis and associated cellular toxicity;Ricardo Sant’Anna等;《NATURE COMMUNICATIONS》;20160223;第1-13页 *
Ricardo Sant’Anna等.Repositioning tolcapone as a potent inhibitor of transthyretin amyloidogenesis and associated cellular toxicity.《NATURE COMMUNICATIONS》.2016,第1-13页. *
国家医药管理局科技教育司组织编写.成酯及成酰胺修饰.《药物化学》.中国医药科技出版社,1996,(第1版),第209页. *

Also Published As

Publication number Publication date
EP3773438A2 (en) 2021-02-17
WO2019195761A2 (en) 2019-10-10
WO2019195761A3 (en) 2020-07-23
CN112601513A (zh) 2021-04-02
JP7532259B2 (ja) 2024-08-13
BR112020020351A2 (pt) 2021-01-12
US20210154213A1 (en) 2021-05-27
US11872236B2 (en) 2024-01-16
JP2021532059A (ja) 2021-11-25
MX2020010502A (es) 2021-03-25

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