CN112587623A - Traditional Chinese medicine composition for soothing nerves and helping sleep, oral liquid containing composition, and preparation method and application of oral liquid - Google Patents

Traditional Chinese medicine composition for soothing nerves and helping sleep, oral liquid containing composition, and preparation method and application of oral liquid Download PDF

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CN112587623A
CN112587623A CN202011535558.1A CN202011535558A CN112587623A CN 112587623 A CN112587623 A CN 112587623A CN 202011535558 A CN202011535558 A CN 202011535558A CN 112587623 A CN112587623 A CN 112587623A
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traditional chinese
chinese medicine
medicine composition
seeds
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杨全红
张科建
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Shandong Hebao Pharmaceutical Co ltd
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Shandong Hebao Pharmaceutical Co ltd
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Abstract

The invention belongs to the technical field of medicines, and particularly relates to a traditional Chinese medicine composition for soothing nerves and helping sleep, and a preparation method and application thereof. The traditional Chinese medicine composition is composed of the following traditional Chinese medicine raw materials in parts by weight: 10-20 parts of raw wheat kernels, 5-20 parts of dark plums, 20-40 parts of lilies, 5-20 parts of spina date seeds, 10-20 parts of lotus seeds, 10-30 parts of trifoliate orange seeds and 5-10 parts of donkey-hide gelatin. Clinical experiments prove that the traditional Chinese medicine composition for soothing nerves and helping sleep has a total effective rate of 98.4%, wherein the clinical cure rate is 74.2%, the obvious effect is 17.74%, and the effective rate is 6.45%.

Description

Traditional Chinese medicine composition for soothing nerves and helping sleep, oral liquid containing composition, and preparation method and application of oral liquid
Technical Field
The invention belongs to the technical field of medicines, and particularly relates to a traditional Chinese medicine composition for soothing nerves and helping sleep, an oral liquid containing the composition, and a preparation method and application of the oral liquid.
Background
According to surveys, the worldwide experience of insomnia has been nearly 30% of the general population. Wherein the insomnia is serious, and the ratio of the insomnia to sleep can be about 17% only by taking the medicine; the proportion of the elderly insomnia patients aged over 65 years old is higher, and is 5-6 times of that of young people. No matter what difference exists among regions, ages and sexes, all people who have insomnia generally have the problems of difficulty in sleeping and difficulty in sleeping well.
Aiming at the problems of high incidence rate of insomnia, great influence on human health and life, and urgent need to solve the problem of finding a traditional Chinese medicine with good efficacy and high safety.
Patent CN109463589A discloses a spina date seed formula beverage for improving sleep quality, which is characterized in that the formula beverage comprises the following raw materials in parts by weight: 10-30% of spina date seed, 2-10% of ginseng, 10-30% of poria cocos, 10-20% of dark plum fruit, 2-10% of Chinese yam, 2-10% of mulberry, 2-10% of longan aril, 1-10% of lotus seed, 1-10% of lily and 1-10% of lophatherum gracile. The invention has unique formula, the efficacies of various components interact with each other, and the synergistic effect is realized, so that the effects of strengthening the spleen and stomach, tonifying qi and promoting the production of body fluid, calming the heart and tranquilizing the mind, and cooling and quenching thirst are realized together. In the formula, ginseng and arillus longan are used as raw materials. Ginseng is a good nourishing medicinal material essentially, but if the ginseng is taken for a long time, a plurality of side effects, such as mood excitation, dysphoria, insomnia and the like, can also appear, and the side effects are collectively called as ginseng abuse syndrome; but is not conducive to sleep. The longan pulp has the following eating contraindications: (1) it is contraindicated for patients with phlegm-fire in spleen and stomach, damp stagnation, dyspepsia, nausea and emesis. (2) For pregnant women, especially in early gestation period, longan pulp should not be taken to prevent fetal movement and premature delivery. (3) In addition, because of its high glucose content, it is not suitable for diabetics to take more. (4) Long-term consumption of longan can cause excessive internal heat. This is contrary to the treatment of "nourishing yin to reduce pathogenic fire" in traditional Chinese medicine. Therefore, the prescription is suitable for limited people, and is not suitable for people with spleen and stomach fire, pregnant women and diabetes patients to take, and in addition, the prescription is not suitable for long-term taking.
Disclosure of Invention
In order to solve the technical problems, the invention provides a traditional Chinese medicine composition for soothing nerves and helping sleep and a preparation method thereof.
The invention is realized by the following technical scheme:
a traditional Chinese medicine composition for soothing nerves and helping sleep is composed of the following traditional Chinese medicine raw materials in parts by weight:
10-20 parts of raw wheat kernels, 5-20 parts of dark plums, 20-40 parts of lilies, 5-20 parts of spina date seeds, 10-20 parts of lotus seeds, 10-30 parts of trifoliate orange seeds and 5-10 parts of donkey-hide gelatin;
preferably, the traditional Chinese medicine composition for soothing nerves and helping sleep comprises the following traditional Chinese medicine raw materials in parts by weight:
10-15 parts of raw wheat kernels, 15-20 parts of dark plums, 30-40 parts of lilies, 5-10 parts of spina date seeds, 10-15 parts of lotus seeds, 10-20 parts of trifoliate orange seeds and 5-10 parts of donkey-hide gelatin.
More preferably, the traditional Chinese medicine composition for soothing nerves and helping sleep comprises the following traditional Chinese medicine raw materials in parts by weight:
15 parts of raw wheat kernels, 20 parts of dark plums, 40 parts of lilies, 10 parts of spina date seeds, 15 parts of lotus seeds, 10 parts of hovenia dulcis and 10 parts of donkey-hide gelatin.
Every 100ml of the oral liquid containing the traditional Chinese medicine composition for soothing the nerves and helping sleep is composed of the following traditional Chinese medicine raw materials in parts by weight:
60g of liquid medicine
High fructose corn syrup 20g
Stevioside 0.04g
Citric acid 0.1g
Malic acid 0.07g
0.04g of potassium sorbate
Honey 0.64g
The balance being water.
In the oral liquid of the traditional Chinese medicine composition for soothing nerves and aiding sleep, the preparation method of the liquid medicine comprises the following steps: taking 10-20 parts of crude wheat kernels, 5-20 parts of dark plum, 20-40 parts of lily, 5-20 parts of spina date seeds, 10-20 parts of lotus seeds and 10-30 parts of trifoliate orange seeds, adding the medicinal materials, soaking for 60min by 10 times of water, slightly boiling for 100min, filtering decoction dregs, adding donkey-hide gelatin into the filtrate while the filtrate is hot, stirring and dissolving, adding a clarifying agent, taking the supernatant, concentrating to 5 times of the amount of the medicinal materials, standing for 16-24 h, centrifuging at a high speed of 10000r/min, centrifuging for 5min, and taking the supernatant as concentrated liquid medicine for later use.
The preparation method of the oral liquid of the traditional Chinese medicine composition for soothing the nerves and helping sleep comprises the following steps: adding high fructose syrup, stevioside, citric acid, malic acid, potassium sorbate and Mel into the concentrated solution, mixing, adding purified water to a specified amount, stirring to dissolve completely, bottling, and sterilizing at 100 deg.C for 20 mi.
The application of the traditional Chinese medicine composition for soothing the nerves and helping sleep in preparing the medicine or food for treating insomnia.
In the traditional Chinese medicine composition for soothing nerves and helping sleep of the invention,
hovenia dulcis, hovenia dulcis thunb, wood honey, tree honey, wood leaven, white stone wood, honey troops, chicken's gizzard-membrane, balsam pear, surimi-surgara seed, Chinese date, Japanese raisin tree, Japanese raisin Tree, sarcandra glabra, chicken claw, chicken orange, Chinese knotweed, Japanese holly root, white stone jujube, pawpaw, pear, sweet midnight, dragon claw, pecan, ramulus Uncariae cum uncis, wild jujube, chicken claw, jujube, Japanese raisin tree, orange button, Japanese raisin tree and fructus Cinchonae. Is mature seed of Hovenia dulcis Thunb [ H.dulcis Thunb.var.glabrara Makino ], Hovenia acerba Lindl [ H.dulcis auct.non Thunb ] and Hovenia tricchart Chun et Tsiang. There are also fruits with rachis. Sweet in taste; the nature is flat; meridian entered heart, spleen and lung meridians; the functional indications are as follows: relieving alcoholism; quenching thirst and relieving restlessness; preventing vomiting; is beneficial to relieving the bowels. Mainly drunk; polydipsia; vomiting; it is not good for the bowels.
All other medicines are the traditional Chinese medicines recorded in the first part of the Chinese pharmacopoeia 2015 edition.
The raw material medicines of the traditional Chinese medicine composition for soothing the nerves and helping sleep are traditional Chinese medicines which are published by Weijian Wei and are both foods and medicines.
The traditional Chinese medicine composition for soothing nerves and helping sleep disclosed by the invention has the formula mechanism as follows:
1. typing and treatment method for insomnia by traditional Chinese medicine
(1) Insomnia due to deficiency of heart-qi and gallbladder-qi
The syndrome: mainly manifested by insomnia and dreamful sleep, restlessness and insomnia accompanied by easy awakening, timidity and palpitation, fright in case of physical disability, timidity and easy fright, qi deficiency, pale tongue and thready pulse;
therapeutic method: replenishing qi, relieving convulsion, tranquilizing the mind
(2) Insomnia with disharmony between heart and kidney
The syndrome: vexation, insomnia, palpitation, vertigo, tinnitus, amnesia, dysphoria with feverish sensation in chest, palms and soles, dry throat, soreness of the waist and knees, spermatorrhea, leukorrhagia, red tongue, and thready and rapid pulse;
treatment is proper: nourishing yin to reduce pathogenic fire and harmonizing heart and kidney
(3) Insomnia due to food stagnation
The syndrome: it is mainly manifested as insomnia and dreaminess, abdominal distention, poor appetite, thick and greasy tongue coating, dirty and turbid tongue coating, and slippery pulse;
treatment is proper: promoting digestion, removing food stagnation, regulating stomach function and tranquilizing
(4) Insomnia due to deficiency of both heart and spleen
The syndrome: it is commonly seen in consumptive disease, palpitation, severe palpitation, insomnia, amnesia, vertigo, blood syndrome, pale tongue with white coating, and thready pulse;
therapeutic method: tonifying heart and spleen, nourishing blood and tranquilization;
(5) phlegm-heat disturbing the heart type insomnia
The syndrome: mainly shows that except insomnia, the traditional Chinese medicine also has symptoms of phlegm-heat such as heavy head, excessive phlegm, chest distress, heavy head and dizziness, nausea, indigestion, eructation, acid regurgitation, vexation, bitter taste in mouth, dizziness and the like, the coating is greasy and yellow, and the pulse is smooth and rapid;
treatment is proper: clearing and resolving phlegm-heat
(6) Insomnia with liver depression transforming into fire
The syndrome: mainly manifested by insomnia, accompanied by symptoms such as dryness, irritability, poor appetite, thirst with desire for drink, dry mouth and throat, conjunctival congestion, bitter taste, yellow and red urine, constipation, etc., red tongue with yellow coating, and wiry pulse;
treatment is proper: soothing the liver, purging fire, calming the heart and tranquilizing the mind
2. General therapeutic principle
By integrating the classification of insomnia, the overall treatment rule of traditional Chinese medicine on insomnia is as follows: tranquilizing mind, strengthening spleen and stomach, nourishing yin, and purging pathogenic fire.
3. Prescription for relieving constipation
(1) Hovenia dulcis
Zhi Zhen Zi can be used for treating various diseases. Fruit stalks, fruits, seeds, leaves and roots can be used as the medicine, and the fruits are called as the hovenia dulcis chessmen. The medicinal use was first seen in Tang Ben Cao. Li Shizhen (compendium of materia Medica) says that it has the effects of tranquilizing and removing heat, and has the effects of quenching thirst, relieving restlessness, removing diaphragm heat, moistening five internal organs, facilitating urination and defecation, and being used with honey.
The medicinal materials have the functions: has effects of tranquilizing mind, calming heart, and clearing away heat.
(2) Wild jujube seed
The common wild jujube seed has the functions of tonifying heart and kidney, reducing blood pressure, calming nerves, tranquilizing and regulating nerves. According to the records of the book of materia medica, the spine date seed is mainly worried about and sleepless. The spina date seed has the effects of nourishing heart and tonifying liver, calming heart and tranquilizing mind, arresting sweating and promoting fluid production, and is mainly used for treating dysphoria and insomnia, palpitation and dreaminess, body deficiency and hyperhidrosis, body fluid deficiency and thirst.
The medicinal materials have the functions: has effects of calming heart, tranquilizing mind, and nourishing yin.
(3) Raw wheat kernel
The wheat kernels are rich in nutrition and cellulose, and can have the effects of coordinating intestines and stomach and promoting digestion; the wheat kernels are sweet in nature and neutral in flavor, have the functions of nourishing the heart and soothing the nerves, and are suitable for symptoms such as restlessness and insomnia; the wheat kernel can tonify qi, astringe heart fluid and remove deficiency heat, and the compatibility of different traditional Chinese medicines can be used for treating symptoms such as yin deficiency fever, bone steaming and internal heat.
The medicinal materials have the functions: has effects in invigorating spleen, calming heart, and tranquilizing mind.
(4) Lotus seed
Lotus seed, a name of traditional Chinese medicine, is the mature seed of Nelumbo nucifera Gaertn. Sweet and astringent taste and mild nature; it is entered into spleen and kidney. Has effects in stopping leukorrhagia, invigorating spleen, relieving diarrhea, invigorating kidney, and nourishing heart. It can be used for treating chronic diarrhea due to spleen deficiency, anorexia, kidney qi deficiency, nocturnal emission and spermatorrhea due to insecurity of essence closure, whitish and turbid urine due to imbalance between heart and kidney, nocturnal emission and spermatorrhea, spleen deficiency, leukorrhagia due to downward flow of water-dampness, imbalance between heart and kidney, vexation, and insomnia.
The medicinal materials have the functions: has effects in invigorating spleen, nourishing heart, and invigorating kidney.
(5) Lily bulb
The lily is a fleshy scaly leaf of lily brown f.e.brown var.viridulium baker or lily L.pulimum DC. belonging to Lilium of Liliaceae, and has effects of nourishing yin, moistening lung, clearing heart fire and tranquilizing mind. It is mainly used for treating yin deficiency dry cough, cough with hemoptysis, insomnia and palpitation due to yin deficiency with heat, and heart-lung yin deficiency internal heat syndrome due to lily disease.
The medicinal materials have the functions: has effects of clearing heart fire, tranquilizing mind, nourishing yin and moistening lung.
(6) Dark plum fruit
Dark plum, named as a traditional Chinese medicine, is a nearly mature fruit of plum Prunus mume (Sieb.) of Prunus of Rosaceae. Has effects in astringing lung, relieving cough, relieving diarrhea with astringents, relieving ascaris, relieving pain, promoting salivation, and quenching thirst. Can be used for treating lung deficiency, chronic cough, chronic diarrhea, chronic dysentery, abdominal pain due to ascariasis, emesis, and diabetes due to deficiency heat.
The medicinal materials have the functions: has effects in astringing lung, relieving cough, relieving diarrhea with astringents, relieving ascaris, relieving pain, promoting salivation, quenching thirst, clearing away heat, and nourishing yin.
(7) Donkey-hide gelatin
Donkey-hide gelatin, a Chinese patent medicine, is composed of donkey hide. Has effects in replenishing blood, nourishing yin, moistening dryness, and stopping bleeding. Can be used for treating blood deficiency, sallow complexion, giddiness, palpitation, vexation, insomnia, lung dryness and cough.
The function of the medicinal materials; has effects in replenishing blood, nourishing yin, moistening dryness, stopping bleeding, calming heart, and tranquilizing mind.
Insomnia is mainly manifested by: (1) it is difficult to sleep. People often have difficulty falling asleep or thinking of sleep due to the effects of environmental influences, anxiety, disease states, and the like. After lying in bed, the user turns over to cover the pillow and can not fall asleep, and some people have much thought and worry in mind. Some people worry about the sleep quality of the people, think that the people cannot sleep in the evening, worry about insomnia again and cannot fall asleep; some people have difficulty in realizing the sleep process because of improper temperature and excessive noise.
(2) It is difficult to sleep well. Some people in insomnia people belong to a particularly sensitive class, and can wake up as long as the external world has slight stimulation; although a person who faces anxiety, tension and stress for a long time sleeps for a long time, the poor mood and poor emotion are always volatile and can be expressed through the dream, because night dreams \32429, the person may wake up and feel that energy is not recovered after waking up.
The main hazards caused by long-term insomnia are:
(1) listlessness, exhaustion, emotional instability and attention deficit; (2) anxiety disorders are triggered; vegetative nerve functional disturbance, susceptibility to hyperfunction of nerve and the like; (3) hyperhidrosis of palms and soles, palpitation, fast heartbeat, rapid respiration obstruction, muscle contraction, trembling, urgent micturition and frequent micturition and chest compression appear; (4) abdominal distension and diarrhea, pharyngeal obstruction, hyperhidrosis, and numbness of limbs; (5) sociality can also be extremely harmful, becoming doubtful, sensitive, irritable, and rather confident.
The invention has the beneficial effects that:
(1) the raw material medicines of the traditional Chinese medicine composition for soothing the nerves and helping sleep are all medicinal and edible traditional Chinese medicines published by Weijian Wei Jian Wei. It can be used as food, and has high safety and no adverse side effect.
(2) Clinical experiments prove that the traditional Chinese medicine composition for soothing nerves and helping sleep has a total effective rate of 98.4%, wherein the clinical cure rate is 74.2%, the obvious effect is 17.74%, and the effective rate is 6.45%.
(3) After the traditional Chinese medicine composition for soothing the nerves and helping sleep is used by a patient, the sleep is improved obviously, the sleep time is recovered to be normal, the sleep is deep, and the patient is energetic after waking up.
(4) The traditional Chinese medicine composition for soothing nerves and helping sleep is suitable for a wide range of people and is suitable for various insomnia. Can be taken for a long time.
Detailed Description
The present invention will be further described with reference to specific examples so that those skilled in the art may better understand the present invention, but the present invention is not limited thereto.
Embodiment 1 a traditional Chinese medicine composition for soothing nerves and aiding sleep comprises the following traditional Chinese medicine raw materials in parts by weight:
15 parts of raw wheat kernels, 20 parts of dark plums, 40 parts of lilies, 10 parts of spina date seeds, 15 parts of lotus seeds, 10 parts of hovenia dulcis and 10 parts of donkey-hide gelatin.
Embodiment 2 a traditional Chinese medicine composition for soothing nerves and aiding sleep, which comprises the following traditional Chinese medicine raw materials in parts by weight:
10 parts of raw wheat kernels, 20 parts of dark plums, 30 parts of lilies, 10 parts of spina date seeds, 10 parts of lotus seeds, 20 parts of hovenia dulcis and 5 parts of donkey-hide gelatin.
Embodiment 3 a traditional Chinese medicine composition for soothing nerves and aiding sleep, which comprises the following traditional Chinese medicine raw materials in parts by weight:
15 parts of raw wheat kernels, 15 parts of dark plums, 40 parts of lilies, 5 parts of spina date seeds, 15 parts of lotus seeds, 10 parts of hovenia dulcis and 10 parts of donkey-hide gelatin.
Embodiment 4 a traditional Chinese medicine composition for soothing nerves and aiding sleep, which comprises the following traditional Chinese medicine raw materials in parts by weight:
10 parts of raw wheat kernel, 20 parts of dark plum, 20 parts of lily, 20 parts of spina date seed, 10 parts of lotus seed, 30 parts of trifoliate orange seed and 5 parts of donkey-hide gelatin.
Embodiment 5 a traditional Chinese medicine composition for soothing nerves and aiding sleep comprises the following traditional Chinese medicine raw materials in parts by weight:
20 parts of raw wheat kernels, 5 parts of dark plums, 40 parts of lilies, 5 parts of spina date seeds, 20 parts of lotus seeds, 10 parts of hovenia dulcis and 10 parts of donkey-hide gelatin.
Embodiment 6 preparation method of oral liquid of traditional Chinese medicine composition for soothing nerves and aiding sleep
(1) Preparation of concentrated medicinal liquid
Taking 15kg of raw wheat kernels, 20kg of dark plums, 40kg of lily, 10kg of spina date seeds, 15kg of lotus seeds, 10kg of semen hoveniae and 10kg of donkey-hide gelatin, adding medicinal materials, soaking for 60min by using 10 times of water, slightly boiling for 100min, filtering medicine residues, adding donkey-hide gelatin into filtrate while the filtrate is hot, stirring and dissolving, adding a clarifying agent, taking supernatant for concentrating until the amount is 5 times of the medicinal materials, standing for 16-24 hours, centrifuging at a high speed of 10000r/min for 5min, and taking the supernatant as concentrated liquid for later use;
(2) the concentrated liquid medicine is taken and added with other auxiliary materials to prepare the oral liquid of the traditional Chinese medicine composition for calming the nerves and helping sleep, and each 10000ml of the oral liquid consists of the following traditional Chinese medicine raw materials in parts by weight:
6000g of liquid medicine
High fructose corn syrup 2000g
Stevioside 4g
Citric acid 10g
Malic acid 7g
Potassium sorbate 4g
Honey 64g
The balance of water;
the preparation method of the oral liquid of the traditional Chinese medicine composition for soothing the nerves and helping sleep comprises the following steps:
adding high fructose syrup, stevioside, citric acid, malic acid, potassium sorbate and Mel into the concentrated solution, mixing, adding purified water to specified amount, stirring to dissolve completely, bottling, sterilizing at 100 deg.C for 20min, testing, labeling, and packaging.
Example 7 preparation method of an oral liquid of a traditional Chinese medicine composition for soothing nerves and aiding sleep
The difference from example 6 is that the concentrated medicinal solution prepared in step (1) is prepared as follows: 10kg of raw wheat kernels, 20kg of dark plums, 30kg of lilies, 10kg of spina date seeds, 10kg of lotus seeds, 20kg of hovenia dulcis seeds and 5kg of donkey-hide gelatin; the other preparation was the same as in example 6.
Embodiment 8 preparation method of oral liquid of traditional Chinese medicine composition for soothing nerves and aiding sleep
The difference from example 6 is that the concentrated medicinal solution prepared in step (1) is prepared as follows: 15kg of raw wheat kernels, 15kg of dark plums, 40kg of lily, 5kg of spina date seeds, 15kg of lotus seeds, 10kg of hovenia dulcis and 10kg of donkey-hide gelatin; the other preparation was the same as in example 6.
Example 9 preparation method of an oral liquid of a traditional Chinese medicine composition for soothing nerves and aiding sleep
The difference from example 6 is that the concentrated medicinal solution prepared in step (1) is prepared as follows: 10kg of raw wheat kernels, 20kg of dark plums, 20kg of lilies, 20kg of spina date seeds, 10kg of lotus seeds, 30kg of trifoliate orange seeds and 5kg of donkey-hide gelatin; the other preparation was the same as in example 6.
Example 10 preparation method of an oral liquid of a traditional Chinese medicine composition for soothing nerves and aiding sleep
The difference from example 6 is that the concentrated medicinal solution prepared in step (1) is prepared as follows: 20kg of raw wheat kernels, 5kg of dark plums, 40kg of lily, 5kg of spina date seeds, 20kg of lotus seeds, 10kg of hovenia dulcis and 10kg of donkey-hide gelatin; the other preparation was the same as in example 6.
Effectiveness and safety evaluation experiments are carried out on the oral liquid for soothing the nerves and helping sleep prepared in example 6, and details are as follows:
first, test purpose
The effectiveness and the safety of the tranquilizing oral liquid product of Shandong Hebao medicine industry Co.
Second, volunteer selection
20 volunteers, 18-45 years old, with no gender, who met the following diagnostic criteria were recruited; insomnia is the first complaint; the Pittsburgh sleep quality index scale (PSQI) total score is more than or equal to 8. The groups were randomized into test and control groups of 10 people each.
2.1 inclusion criteria:
meets the Chinese traditional medical diagnosis and treatment guidelines for insomnia in the 3 rd edition of Chinese mental disorder classification and diagnosis standard (CcmD-3).
Dissatisfaction with the quality of sleep for a long time, and other related clinical symptoms, affecting the functioning of work, learning or social activities.
Sleep disorder: including difficulty in falling asleep, inability to sleep for a long time, or intermittent waking, dreaminess all night, non-sleep or early waking, inability to fall asleep after waking, or difficulty in sleeping all night.
The sleep disorder occurs at least 3 times per week for more than 2 weeks.
The symptoms of lassitude, dizziness, fullness in the head, palpitation, vexation and the like appear in the daytime, and the functions of work, study and social activities are influenced.
2.2 exclusion criteria:
medicines and health-care foods related to the tested functions are taken orally for 1 week;
insomnia due to other reasons: insomnia caused by severe physical and mental diseases (such as schizophrenia, depression, anxiety, etc.);
the serious insomnia is treated by other hypnotics repeatedly and is not effective.
Known to be allergic to the components of the product (the product components comprise colla Corii Asini, Mel, semen Nelumbinis, semen Ziziphi Spinosae, fructus Hordei Germinatus, semen Hoveniae extract);
patients with immune system deficiency and hypofunction, and serious blood, cardiovascular, cancer, etc.; the severe Vaccinium uliginosum or late stage disease; lactating and pregnant women.
Third, test method
Test groups: the tranquilizing plant beverage is orally taken before sleep, 50mL of the tranquilizing plant beverage is taken each time, 1 time per day, and 30 days are a treatment course. The next course of treatment can be taken after 1 month interval.
Control group: before sleep, the nerve-soothing plant drink matrix is orally taken, 50mL of the matrix is taken each time, 1 time per day, and 30 days are a treatment course.
Fourth, observation of curative effect
4.1 evaluation node
1 evaluation was made before treatment, 7 days, 13 days, 19 days, 25 days, 31 days after treatment.
4.2 observation indexes:
scoring the Pesburg sleep index Scale (PSQI) scores (including sleep quality, time to sleep, sleep time, sleep efficiency, sleep disturbance, hypnotic, daytime dysfunction, total score) before and after treatment of the test subject. And observing the occurrence condition and rebound condition of adverse reaction during and after the treatment course, and recording all adverse events.
4.3 therapeutic effect standard:
the method is formulated according to the clinical research guidelines of treating insomnia with new traditional Chinese medicines. The clinical cure is as follows: recovering normal sleep time or sleep time above 6h, deep sleep, and waking up with abundant energy; the effect is shown: the sleep is improved obviously, and the sleep time is increased by more than 3 h; the method has the following advantages: the sleep time is increased compared with that before treatment, but is less than 3 hours; and (4) invalidation: sleep was not significantly improved.
Fifth, conclusion
Group and treatment summary (general group 62)
Male: 28 persons, 6 persons 18-25 years old; 25-35 years old: 10 persons; 35-50 years old; 12 persons
For the woman: 34, 14 at 18-25 years old; 25-35 years old: 12 persons; 35-50 years old: 8 persons
The tranquilization plant beverage is taken 50 ml/day before sleep and 30 days
Figure DEST_PATH_IMAGE002
The total effective rate is as follows: 98.4 percent. Wherein the clinical cure rate is 74.2%, the obvious effect is 17.74% and the effective effect is 6.45%.
The nerve-soothing plant beverage has good nerve-soothing and sleep-helping effects.

Claims (7)

1. The traditional Chinese medicine composition for soothing nerves and helping sleep is characterized by comprising the following traditional Chinese medicine raw materials in parts by weight:
10-20 parts of raw wheat kernels, 5-20 parts of dark plums, 20-40 parts of lilies, 5-20 parts of spina date seeds, 10-20 parts of lotus seeds, 10-30 parts of trifoliate orange seeds and 5-10 parts of donkey-hide gelatin.
2. The traditional Chinese medicine composition for soothing nerves and aiding sleep according to claim 1, which is characterized by comprising the following traditional Chinese medicine raw materials in parts by weight:
10-15 parts of raw wheat kernels, 15-20 parts of dark plums, 30-40 parts of lilies, 5-10 parts of spina date seeds, 10-15 parts of lotus seeds, 10-20 parts of trifoliate orange seeds and 5-10 parts of donkey-hide gelatin.
3. The traditional Chinese medicine composition for soothing nerves and aiding sleep according to claim 2 is characterized by comprising the following traditional Chinese medicine raw materials in parts by weight:
15 parts of raw wheat kernels, 20 parts of dark plums, 40 parts of lilies, 10 parts of spina date seeds, 15 parts of lotus seeds, 10 parts of hovenia dulcis and 10 parts of donkey-hide gelatin.
4. The oral liquid containing the traditional Chinese medicine composition for soothing the nerves and aiding sleep of any one of claims 1 to 3 is characterized in that each 100ml of the oral liquid consists of the following traditional Chinese medicine raw materials in parts by weight:
60g of liquid medicine
High fructose corn syrup 20g
Stevioside 0.04g
Citric acid 0.1g
Malic acid 0.07g
0.04g of potassium sorbate
Honey 0.64g
The balance being water.
5. The oral liquid of a traditional Chinese medicine composition for soothing nerves and aiding sleep according to claim 4, which is prepared by the following steps: taking 10-20 parts of crude wheat kernels, 5-20 parts of dark plum, 20-40 parts of lily, 5-20 parts of spina date seeds, 10-20 parts of lotus seeds and 10-30 parts of trifoliate orange seeds, adding the medicinal materials, soaking for 60min by 10 times of water, slightly boiling for 100min, filtering decoction dregs, adding donkey-hide gelatin into the filtrate while the filtrate is hot, stirring and dissolving, adding a clarifying agent, taking the supernatant, concentrating to 5 times of the amount of the medicinal materials, standing for 16-24 h, centrifuging at a high speed of 10000r/min, centrifuging for 5min, and taking the supernatant as concentrated liquid medicine for later use.
6. The preparation method of the oral liquid of the traditional Chinese medicine composition for soothing nerves and aiding sleep, which is characterized by comprising the following steps: adding high fructose syrup, stevioside, citric acid, malic acid, potassium sorbate and Mel into the concentrated solution, mixing, adding purified water to a specified amount, stirring to dissolve completely, bottling, and sterilizing at 100 deg.C for 20 min.
7. The use of the traditional Chinese medicine composition for soothing nerves and aiding sleep of claim 1, 2 or 3 in the preparation of drugs or foods for treating insomnia.
CN202011535558.1A 2020-12-23 2020-12-23 Traditional Chinese medicine composition for soothing nerves and helping sleep, oral liquid containing composition, and preparation method and application of oral liquid Pending CN112587623A (en)

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Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104351757A (en) * 2014-10-11 2015-02-18 王�琦 Food for improving yin deficiency constitution and preparation technology of food

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104351757A (en) * 2014-10-11 2015-02-18 王�琦 Food for improving yin deficiency constitution and preparation technology of food

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
张海龙等: "宋兰主任中医师辨治失眠的经验", 《中国医疗前沿》 *
李玮等: "《生命健康养护宝典》", 31 July 2017, 陕西科学技术出版社 *
薄智云: "《腹针无痛治百病》", 31 October 2012, 中国中医药出版社 *

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Application publication date: 20210402