CN106929363B

CN106929363B - Health wine and preparation method thereof

Info

Publication number: CN106929363B
Application number: CN201710296403.9A
Authority: CN
Inventors: 陈安新; 陈育新
Original assignee: Xinjiang Shengmingheli High Tech Co ltd
Current assignee: Xinjiang Shengmingheli High Tech Co ltd
Priority date: 2017-04-28
Filing date: 2017-04-28
Publication date: 2020-11-13
Anticipated expiration: 2037-04-28
Also published as: CN106929363A

Abstract

The invention provides a health wine and its preparation method, the wine contains herba cistanches 20-60 parts, herba Epimedii 20-40 parts, mulberry 10-30 parts, fructus Lycii 10-30 parts, fructus Corni 10-30 parts, fructus Jujubae 10-30 parts, cornu Cervi Pantotrichum 1-2 parts, crystal sugar 45-65 parts, adopt soak, filter, concoct, store wine, irritate wine, capping process to prepare get final product, the wine of the invention has solved the short problem of traditional health product storage cycle well, prepare into the wine and improve the potency, utilize several Chinese medicines to formulate through rational proportion, it has many health promoting effects such as invigorating vital energy and tonifying deficiency, moistening five internal organs, and blood vessel, benefiting vital essence and qi, replenishing essence and marrow, strengthening muscle and bone, spleen and stomach, supporting yang, soak in the wine base, add water and concoct the alcoholic strength and add crystal sugar to make up, clear and transparent through sensory detection, the product is transparent, said product is suitable for many years, it can be used for the health care of the health, Has good taste and wide adaptability in the fields of treating chronic fatigue syndrome and health care.

Description

Health wine and preparation method thereof

Technical Field

The invention mainly relates to the technical field of health-care products, in particular to a health-care wine and a preparation method thereof.

Background

Fatigue is a subjective feeling of discomfort, but objectively loses its ability to perform the normal activities or work originally undertaken under the same conditions. If the patient usually feels tired and cannot concentrate attention in daily life, the patient can be tired by a little exercise, the patient can sleep more but not feel tired at ordinary times, and the patient can go to a hospital for physical examination without serious pathological changes, so that the patient can suffer from Chronic Fatigue Syndrome (CFS). The CFS definition at the 1994 conference of the international chronic fatigue syndrome team is: fatigue persists for 6 months or more, excluding other diseases, and possesses at least 4 of the following symptoms: short-term memory decline or inability to concentrate attention; ② sore throat; ③ lymph node pain; fourthly, muscle soreness is caused; joint swelling and pain without red swelling; sixthly, headache is caused by new hair; seventhly, after sleeping, vigor cannot be recovered; the people are discomfortable for 24 hours continuously after the physical or mental labor.

Fatigue belongs to the categories of deficiency, consumptive disease and consumptive disease in traditional Chinese medicine, and is often called fatigue, abortive, thin, heavy and heavy in Huang Di Nei Jing. Su Wen & Zhao Yi Lun (literature article of monograph) states that "liver deficiency, kidney deficiency and spleen deficiency all make the human body be very restless and dry, and according to the theory of traditional Chinese medicine visceral manifestation, fatigue is related to five zang organs, and mainly responsible for spleen, liver and kidney and heart and lung. Failure of the spleen to transport and transform leads to the failure of qi and blood to transform and transform, failing to nourish the muscles of the limbs, manifesting as lassitude, weakness, or flaccidity. In addition, spleen governs transportation and transformation of water-dampness, spleen functions of transportation and transformation of water-dampness are declined, and it is easy to generate dampness and gather phlegm, and phlegm-dampness stagnates in the muscles of limbs, which is manifested as heavy and weak limbs, even soreness and pain. Liver stores blood and governs tendons as the root of death, stores blood, regulates blood volume and can ensure normal distribution of blood during exercise. Kidneys are the innate root, store essence and govern bone and marrow. Indulgence in sexual desire, excessive fatigue, kidney essence deficiency, marrow sea deficiency, listlessness, vertigo, tinnitus, hypomnesis, thought retardation, soreness and weakness of the waist and knees, debility of limbs, fatigue and weakness. Fatigue is also related to the visceral functions of the heart and lung. The heart governs blood vessels, and heart qi promotes the circulation of blood throughout the body, and the blood flows throughout the body to play a role in nourishing and moistening. Heart stores spirit and has all physiological functions of the human body, such as internal organs, body sense organs and orifices, and mental consciousness and thinking activities. Sufficient heart blood, vigorous heart qi and heart spirit, so blood can move, blood vessels are smooth and vital energy is vigorous. The lung governs qi, governs respiration, and moves towards the heart and blood. Excessive labor, lung impairment due to qi consumption, lung qi deficiency, and failure to help heart and blood circulation, blood stasis, manifested as palpitation and chest distress. Therefore, fatigue is often accompanied by qi deficiency symptoms such as lassitude and laziness in speaking. The traditional Chinese medicine considers that the generation of physical strength takes qi, blood, body fluid and liquid as material bases and takes the functions of yin and yang as external manifestations. The generation of fatigue is closely related to the loss of qi, blood, yin and yang. In a word, the traditional Chinese medicine considers that the fatigue is mainly caused by dysfunction of three organs, namely spleen, liver and kidney, heart and lung involvement and imbalance of qi, blood, yin and yang, which are caused by various reasons.

According to statistics, the incidence rate of the chronic fatigue syndrome in 90 years in the 20 th century is 20% -30%, the community survey in England finds that the prevalence rate of women is higher than that of men, about 30% of women and about 18% -19% of men, and the statistical data in China find that the proportion of men and women is almost the same. The patient group is mainly brainworkers engaged in the industries of computer software development, secretary, financial staff and the like, the social pressure, the mental pressure, the working pressure and the living pressure of the patient group are very large, and in addition, the modern society is high in intensity and fast in rhythm, and complicated modern social environment, interpersonal relationship and intense competition, so that the body and the mind of the patient are exhausted, the stress, the pressure, the anxiety and the unappreciated feeling of the patient are easily generated, and various bad moods such as anxiety, vexation, depression, self-mutilation, low mood and the like are caused. If the mental tension state can be moderate, the mental tension state is beneficial to the acquisition and the health, but if the mental tension state is too strong and the self psychological bearing capacity is not strong, the psychological fatigue is inevitable, so that the chronic fatigue syndrome is easy to generate.

The medicated liquor is a clear liquid preparation prepared by extracting medicinal materials with Chinese liquor. The wine has the characteristics of flexible formula, simple and convenient preparation, convenient taking and quick response, and has thousands of years of history in China. The wine formula is also one of the important dosage forms of the traditional Chinese medicine formula. The wine can promote the efficacy of the medicine: the wine is sweet, slightly pungent and slightly bitter. Pungent flavor can disperse and move, and bitter flavor can purge. Heat, moving without staying on the body, can move through the meridians and blood vessels, go on the surface of the whole body, go up to the vertex and go down to the tarsal region, and can be used for moving medicine without any place. The compound is prepared in a prescription, can improve the curative effect of the medicine and quickly play the role of the medicine. The wine can also strengthen the body and strengthen the body resistance, and avoid dirtiness and remove dirt. The wine has sweet taste and can tonify, has the functions of nourishing intestines and stomach and nourishing spleen qi, and has the functions of regulating blood and promoting qi circulation, strengthening spirit and resisting cold and worries about joyful; the wine is fragrant and hot, so it can expel cold, dampness, dirt and epidemic fulminant and kill all pathogens to calm the body.

According to the traditional Chinese medicine, the wine is the smell of food, is pungent and sweet in taste, is strong in nature and hot, has fragrant and mellow smell, enters heart and liver meridians, can ascend and disperse energy, is suitable for guiding medicine vigor, and has the functions of invigorating spleen and stomach, eliminating cold accumulation, correcting odor and correcting taste. The wine is taken as a dosage form, besides being capable of dissolving various active ingredients in medicinal materials, the wine base can moderate the performance of the medicaments and correct the bias; the medicine can be guided to the channels and the effect can be strengthened; the medicine property can be changed to expand or change the curative effect of the original medicine; can also reduce the toxicity or side effect of the original medicine.

At present, the health-care food for relieving physical fatigue in the market mainly comprises the following types: the energy is supplemented, and the purposes of maintaining the normal physiological functions of the body and relieving fatigue are achieved by supplementing energy consumed in sports; secondly, supplying vitamins and trace elements necessary for human body; thirdly, the elimination and discharge of the metabolic substances in the body are accelerated by improving the functions of the organs of the body, particularly the functions of a circulatory system, so as to achieve the aim of resisting fatigue.

However, the traditional health care products have short preservation period and single effect, can not effectively treat chronic fatigue syndrome, and the market urgently needs a health care product with multiple effects of tonifying qi and tonifying deficiency, moistening five internal organs, harmonizing blood vessels, benefiting vital essence and qi, nourishing essence and marrow, strengthening bones and muscles, strengthening spleen and stomach, nourishing yin and tonifying yang and the like, and the health care product can be preserved for a long time and has stable and reliable quality.

Disclosure of Invention

Aiming at the current situation of the prior art, the cistanche deserticola, the epimedium herb, the mulberry, the medlar, the dogwood, the Chinese date, the cervus elaphus linnaeus and the rock sugar are fused into the white spirit to prepare the medicinal liquor by a certain process, so that the problem of short shelf life and unstable quality of the traditional health-care products is well solved, the chronic fatigue syndrome can be effectively treated by reasonably matching a plurality of traditional Chinese medicines with different components, and a new way is found for treating the chronic fatigue syndrome by human beings.

In order to achieve the above object, the present invention provides a technical solution:

the invention provides a health wine, which comprises 20 to 60 parts of cistanche, 20 to 40 parts of epimedium, 10 to 30 parts of mulberry, 10 to 30 parts of medlar, 10 to 30 parts of dogwood, 10 to 30 parts of Chinese date, 1 to 2 parts of cervus elaphus linnaeus and 45 to 65 parts of rock sugar.

Preferably, the wine comprises 40 parts of cistanche, 30 parts of epimedium, 20 parts of mulberry, 20 parts of medlar, 20 parts of dogwood, 20 parts of Chinese date, 1 part of cervus elaphus linnaeus and 55 parts of rock candy.

In the invention, the wine is prepared by the following method:

(1) weighing and cleaning: weighing the medicinal materials in proportion, washing with water, and draining.

(2) Soaking: placing herba Epimedii at bottom of soaking tank, placing the rest materials on the soaking tank, adding 4 times of 65% Chinese liquor, soaking for 4-6 hr, circulating for 15-25 days, filtering, and storing the filtrate in a storage tank; adding 45% white spirit in an amount which is 2.5 times the volume of the soaking tank, soaking for 4-6 hours every day during the soaking period, filtering after 10-20 days, and placing the filtrate in a storage tank; then adding purified water with the volume of 1.0 time for circulation for 2 hours, filtering, and placing the filtrate in a storage tank.

(3) And (3) filtering: standing the liquor obtained by soaking for 3 times for 10-20 days, and filtering the supernatant with diatomaceous earth filter with the amount of diatomaceous earth of 1 kg/1 ton for use.

(4) Blending: mixing the filtrates in the storage tank, adding purified water to obtain 36.5% wine, adding crystal sugar according to formula proportion, stirring and dissolving.

(5) Storing wine: putting the liquor into a storage tank, standing at low temperature for 30 days after passing sensory inspection and alcohol content inspection, filtering, inspecting physical and chemical indexes, and preparing for filling.

(6) Washing bottles and sterilizing: selecting qualified glass bottles and bottle caps, roughly washing the glass bottles with drinking water, finely washing the glass bottles with purified water, immediately drying, sterilizing and cooling for later use, roughly washing the bottle caps with the drinking water, finely washing the glass bottles with the purified water, soaking the glass bottles in 75% ethanol for 2 hours, sterilizing and drying for later use.

(7) Filling wine and sealing: and opening the filling machine, adjusting to the specified filling amount of 500ml, immediately sealing the cover after filling, checking the sealing performance, removing unqualified products by adopting a lamp, and then filling into an outer package.

Preferably, the preparation method of the invention is that the wine soaking liquid in the tank circulates for 6 hours every day during the wine soaking period, the filtration is carried out after 25 days, and the filtrate is placed in the storage tank; circulating for 6 hours every day after the white spirit is put into the soaking tank, filtering after 20 days, and putting the filtrate into a storage tank; adding purified water with the volume of 1.0 time for circulating for 2 hours, filtering, and placing filtrate in a storage tank; standing the liquor obtained by 3 times soaking for 20 days, and filtering the supernatant with diatomaceous earth filter.

The pharmacological mechanism of the health care wine of the invention is as follows:

cistanche deserticola: cistanche deserticola is dry fleshy stem with scale leaves of cistanche deserticola or cistanche tubulosa which is a perennial parasitic herbaceous plant of broomrape, and is mainly parasitic on the root of halaxylon ammodendron forest or halaxylon ammodendron which is shrub chenopodiaceae. Cistanchis herba is sweet, salty and warm in nature. Belongs to kidney and large intestine channels, has the efficacies of tonifying kidney yang, benefiting essence and blood, tonifying middle-jiao and Qi and relaxing bowel, and is called desert ginseng as a material. The traditional medicine records that the cistanche deserticola as a traditional Chinese medicinal material has two thousand years of use history in China, is recorded in Shen nong Ben Cao Jing and is listed as a superior product. The book "… … in Ben Cao Hui Yan" is a mild tonic, warm but not hot. Tonify without drastic action, warm without dryness, slippery without diarrhea, so it is named desert cistanche (leisurely).

Herba Epimedii is dry leaf of herba Epimedii of berberidaceae, herba Epimedii of sagittaria sagittifolia, herba Epimedii of Epimedium pubescens and herba Epimedii of Korean epimedium, is pungent and sweet in flavor, warm in nature, and enters liver and kidney channels, and has effects of invigorating kidney yang, strengthening tendons and bones, and dispelling pathogenic wind and dampness. It is commonly used for impotence, spermatorrhea, premature ejaculation, leukorrhagia due to deficiency-cold, infertility due to cold womb, frequent micturition, dribbling urination, lumbago due to kidney deficiency, rheumatalgia, spasm of muscles and tendons, numbness of limbs, and paralysis of hands and feet. Li Shizhen is said to have the actions of tonifying qi, strengthening tendons and bones, tonifying waist and knees and strengthening heart force in Ben Cao gang mu. Modern pharmacological research shows that epimedium has the physiological functions of relieving physical fatigue and the like.

Mulberry, mulberry, a dry ear of Moraceae plant, mulberry, also known as mulberry, has a history of use for more than two thousand years in China. The mulberry has rich nutrition, contains various nutrient components necessary for human body, has various nutrient components higher than those of common fruits, and also has medical care effect. The compendium of materia medica records the main indications: benefiting the five internal organs and joints and promoting blood and qi circulation. It can be taken for a long time without hunger, calm soul and tranquilize mind, and make people smart, white and not old. The mulberry is recognized to have the effects of tonifying liver and kidney, nourishing yin and blood, blackening hair and improving eyesight, removing freckles and prolonging life, and is considered as a natural food with nutrition and health care functions by people. Mulberry fruit is indicated for its action in Tang Ben Cao (Tang materia Medica) in Tang dynasty. The traditional Chinese medicine believes that the mulberry is sweet in taste and cold in nature, enters heart, liver and kidney channels, has the effects of nourishing yin and supplementing blood, and can treat yin deficiency, little body fluid, insomnia and the like. In addition, many classical traditional Chinese medicine documents are documented: benefiting five internal organs and joints, promoting blood circulation, tranquilizing, lowering blood pressure, quenching thirst, improving eyesight, whitening, and relieving alcoholism. Clinically, the modern medicine proves that the mulberry has good effects of nourishing heart, liver and kidney, nourishing blood and dispelling wind. Has obvious curative effects on reducing blood fat, relieving neurasthenia, arteriosclerosis, sexual function weakness, deafness and dim eyesight, early white beard and hair, internal heat diabetes, blood deficiency and constipation. Pharmacological research shows that: the mulberry can supplement the lack of gastric juice when entering the stomach, promote the digestion of the gastric juice, promote the secretion of intestinal juice when entering the intestine, promote the gastrointestinal peristalsis and have the effects of tonifying and strengthening. Modern pharmacological research on a mulberry blood system proves that the mulberry can promote the growth of hematopoietic cells, and after a blood-deficiency mouse is infused with mulberry liquid, the values of red blood cells and hemoglobin of the blood-deficiency mouse are recovered to be normal on the 5 th day, and the blood-deficiency symptom of the mouse is obviously improved. The mulberry can promote the growth of hematopoietic cells and the growth of granulosa progenitor cells. The mulberry is listed as a traditional blood-tonifying medicine in modern China together with the tuber fleeceflower root, the angelica, the medlar and the like, has certain curative effects on fatigue anemia, premature graying, urinary incontinence of old people and anemia patients, tinnitus, dizziness and constipation, and has the effects of calming, protecting the liver, diminishing inflammation, relieving pain and the like. Uygur recorded in the medical dictionary has effects of promoting blood circulation, nourishing brain, dredging collaterals, protecting liver, strengthening body constitution, improving sexual desire, strengthening kidney, promoting diuresis, relieving hangover, protecting liver, treating pharyngolaryngitis, tracheitis, aphtha of the mouth and tongue, periodontitis, etc., preventing and treating respiratory tract and dyspepsia, and resisting aging. Mulberry is sweet, cold and moist, enters liver and kidney meridians, can nourish yin of liver and kidney and enrich blood, and has good curative effect on fatigue syndromes such as fatigue, weakness, palpitation, amnesia, dizziness, palpitation, insomnia, soreness and weakness of waist and knees and the like.

Wolfberry fruit, fructus lycii, is the fruit of lycium barbarum, a solanaceae plant, and the traditional medicine believes that the wolfberry fruit has the effects of moistening lung, clearing liver, nourishing kidney, tonifying qi, producing sperm, supporting yang, tonifying deficiency, strengthening bones and muscles and improving eyesight. Modern researches prove that the medlar contains polysaccharide, various vitamins and essential amino acids, and the medlar can promote blood circulation and is very suitable for relieving fatigue.

Dogwood, dogwood is dry and mature pulp of dogwood belonging to the family of dogwood, is an important wild plant resource, is also a traditional Chinese medicinal material in China, has the efficacies of tonifying liver and kidney, and arresting seminal emission, and is commonly used for symptoms such as dizziness and tinnitus, soreness and pain of waist and knees, impotence and spermatorrhea, enuresis, frequent micturition, metrorrhagia and leukorrhagia. The medicinal history of the dogwood is already recorded in 2000, the Ming dynasty Li Shizhen Ben Cao gang mu, and the dogwood has the functions of warming the middle-jiao, expelling cold, wetting spleen, removing turbidity, strengthening yin and benefiting essence, and improving eyesight, strengthening and prolonging life after being taken for a long time, and is a traditional famous and precious Chinese medicinal material for strengthening yin and benefiting essence, and secret essence and securing qi in China. In recent years, the research believes that the dogwood has obvious anti-aging and anti-fatigue effects and also has the effect of enhancing the memory.

Chinese date: fructus Jujubae is mature fruit of Zizyphi fructus of Rhamnaceae. Warm in nature and sweet in flavor, tonify middle-jiao, nourish blood and tranquilize mind, and moderate drug property. The Chinese date recorded in the new compilation of materia medica has the efficacies of dredging nine orifices, mixing various medicines, nourishing lung and stomach, tonifying qi, moistening heart and lung, promoting fluid production, assisting various channels and tonifying five internal organs. The folk also has the saying that the red dates are eaten everyday and are not aged in life. Modern medicine and food research show that the Chinese date has various biological effects of enhancing muscle capacity, resisting fatigue and the like.

Cornu Cervi Pantotrichum, cornu Cervi Pantotrichum is mostly the young horn of spotted deer or red deer without ossification. The cornu Cervi Pantotrichum is obtained by sawing in summer and autumn, drying in shade or oven drying, and slicing cornu Cervi Pantotrichum. The records of Shennong Ben Cao Jing and Ben Cao gang mu are that the pilose antler is sweet and warm in taste, non-toxic, mainly leaks and has aversion to blood, cold and heat fright epilepsy, qi-tonifying and will strengthen the mind, and the teeth are not aged. Recorded in the Chinese pharmacopoeia, Lu Rong can strengthen kidney yang, nourish essence and blood, strengthen tendons and bones, regulate Chong and ren meridians, and relieve sore toxicity. Can be used for treating kidney yang deficiency, essence and blood deficiency, sexual impotence, spermatorrhea, infertility due to cold womb, marasmus, listlessness, aversion to cold, vertigo, tinnitus, cold pain of waist and back, tendons and bones flaccidity, metrorrhagia, leukorrhagia, and vaginal abscess. Modern researches have proved that cornu Cervi Pantotrichum has effects of enhancing immunity, relieving fatigue, tranquilizing mind, and tranquilizing mind.

According to the characteristics of syndrome differentiation and treatment of traditional Chinese medicine, Chronic Fatigue Syndrome (CFS) can be classified into the types of traditional Chinese medicine syndromes such as qi and blood deficiency, liver depression and spleen deficiency, heart and spleen deficiency, liver and kidney yin deficiency, heart and kidney imbalance and the like.

Type of deficiency of both qi and blood: it is mainly manifested as fatigue, weakness, aggravation of movement, pale complexion, lusterless lips and nails, palpitation, insomnia, mental fatigue, disinclination to talk, diet reduction, pale tongue and thready and weak pulse. The treatment mainly aims at tonifying qi and blood and strengthening and activating the spleen and stomach.

Liver stagnation and spleen deficiency: it is mainly manifested as lassitude, weakness, dizziness, palpitation, fullness in the chest and hypochondrium, anorexia, abdominal distention, loose stool, borborborygmus, or abdominal pain with diarrhea, pain after diarrhea, pale tongue with thin and white coating, and wiry pulse. The treatment mainly comprises soothing liver, relieving depression, strengthening spleen and nourishing blood.

Heart-spleen deficiency type: it is mainly manifested as lassitude, weakness, dizziness, palpitation, dreaminess, amnesia, blurred vision, lassitude, tastelessness, pale complexion, pale tongue with thin coating, and thready and weak pulse. The treatment mainly comprises tonifying heart and spleen, nourishing blood and tranquillizing.

Liver-kidney yin deficiency type: the main symptoms are fatigue, weakness, light headedness, tinnitus, amnesia, impatience, irritability, mental stress, eye loss, dreaminess, dysphoria with feverish sensation in the chest, palms and soles, dry throat, red cheeks, soreness and weakness of waist and knees, spermatorrhea, red tongue with little coating and thready and rapid pulse, and the treatment mainly aims at nourishing liver and kidney and nourishing yin and suppressing yang.

Heart-kidney imbalance type: it is mainly manifested as fatigue, weakness, restlessness, amnesia, dreaminess, palpitation, soreness and weakness of waist and knees, spermatorrhea, red tongue tip, thin and yellow coating, thready and weak pulse or thready and rapid pulse, and it is mainly used to nourish yin to lower fire and to communicate heart and kidney.

At present, the diagnosis standards about CFS are not unified, the clinical manifestations are diversified, the main symptoms are insomnia, dreaminess and easy wakening, amnesia, inappetence, abdominal distension, mental depression, dizziness, anorexia, hyposexuality, lumbago, irritability, sore throat and the like, the main signs are pale complexion and wiry pulse, and the research shows that the CFS syndrome distribution is mainly caused by liver and kidney deficiency.

The cistanche deserticola is sweet and salty in taste and warm in nature, can tonify kidney yang and benefit essence and blood, is epimedium, is pungent, sweet and warm in taste, can tonify kidney yang, can strengthen tendons and bones, and can dispel wind-damp, and both herbs enter kidney channels, warm and tonify kidney yang, and accord with the pathogenesis of fatigue; mulberry, fructus lycii; the Chinese date has warm property, is in charge of spleen, stomach and heart channels, can tonify middle-jiao and Qi, nourish blood and tranquilize mind, can tonify deficiency of spleen and stomach, has sweet taste, can harmonize the properties of various medicines in the formula, has the function of correcting taste, and also can be used as a messenger medicine. Therefore, according to the traditional Chinese medicine theory, the raw materials are combined for use, so that the effects of nourishing liver and kidney and tonifying spleen can be achieved together, the pathogenesis of the disease is matched, qi and blood are abundant, the qi activity of internal organs is regulated, and the symptoms of limb lassitude, myalgia, sleep disorder and the like caused by fatigue are relieved.

The invention has the beneficial effects that:

(1) the health wine provided by the invention well solves the problems of short preservation period and instability of the traditional health products, and can improve the drug effect and facilitate long-term preservation by being prepared into the wine.

(2) The invention is prepared by using white spirit and cistanche salsa, epimedium, mulberry, medlar, dogwood, Chinese date and cervus elaphus linnaeus which have the tonifying effect according to a reasonable proportion, and has a plurality of health care effects of tonifying qi and deficiency, moistening the five internal organs, regulating blood vessels, benefiting vital essence and qi, replenishing marrow and essence, strengthening bones and muscles, strengthening spleen and stomach, nourishing yin and tonifying yang and the like. Soaking in wine base, adding water to adjust alcohol content, adding crystal sugar to adjust sugar content, and making into product with transparent and good taste by sensory test; the product has stable quality and reasonable formulation design by stability detection, and has wide adaptability in the fields of treating chronic fatigue syndrome and health care.

Drawings

FIG. 1 is a graph showing the response of Cistanchis herba and Epimedii herba to the effect of therapy.

Fig. 2 shows a response surface graph of cistanche salsa and mulberry on the effect of treatment.

FIG. 3 is a graph showing the response of Cistanchis herba and Lycii Frutus to the effect of therapy.

FIG. 4 is a graph showing the response of Cistanchis herba and Corni fructus to the effect of treatment.

FIG. 5 is a graph showing the response of Cistanchis herba and Zizyphi fructus to the effect of therapy.

FIG. 6 is a graph showing the response of Cistanchis herba and cornu Cervi Pantotrichum to the effect of treatment.

Figure 7 is a graph showing the response of cistanche and rock candy to treatment effects.

FIG. 8 is a graph showing the response of Epimedium herb and Mulberry to the effect of therapeutic effect.

FIG. 9 is a graph showing the response of Epimedium herb and Lycium barbarum on the effect of therapeutic effect.

FIG. 10 is a graph showing the response of Epimedium herb and dogwood to the effect of therapeutic effect.

FIG. 11 is a graph showing the response of Epimedium herb and jujube on the effect of therapeutic effect.

FIG. 12 is a graph showing the response of Epimedium herb and hairy Deerhorn on the therapeutic effect.

Figure 13 shows a response profile of the effect of epimedium and rock candy on efficacy.

Fig. 14 is a graph showing the response of mulberries and wolfberry to the effect of treatment.

Fig. 15 is a graph showing the response of mulberries and dogwood to the effect of treatment.

FIG. 16 is a graph showing the response of Mulberry fruit and Zizyphi fructus to the effect of treatment.

Fig. 17 is a graph showing the response of mulberries and cervus elaphus linnaeus to the effect of therapeutic effect.

Figure 18 shows a response profile of the effect of mulberry and rock candy on efficacy.

FIG. 19 is a graph showing the response of Lycium barbarum fruit and Cornus officinalis to the effect of treatment.

FIG. 20 is a graph showing the response of wolfberry and jujube to the effect of treatment.

FIG. 21 is a graph showing the response of Goji fruit and hairy Deerhorn on the therapeutic effect.

Figure 22 shows a graph of the response of wolfberry and ice confection to treatment.

FIG. 23 is a graph showing the response of Corni fructus and Zizyphi fructus to the effect of therapeutic effect.

FIG. 24 is a graph showing the response of Corni fructus and cornu Cervi Pantotrichum to the effect of therapeutic effect.

Figure 25 is a graph showing the response of cornel and rock candy to the effect of treatment.

FIG. 26 is a graph showing the response of cornu Cervi Pantotrichum and fructus Jujubae to the effect of therapeutic effect.

Figure 27 is a graph showing the response of rock candy and jujube to the effect of treatment.

Figure 28 is a graph showing the response of velvet antler and rock candy to the effects of treatment.

Detailed Description

Specific embodiments of the present invention are described in further detail below, but the formulations and methods of the present invention are not limited to the examples below.

The first embodiment is as follows: the invention relates to a health wine

In the invention, the wine comprises 20 to 60 parts of cistanche, 20 to 40 parts of epimedium, 10 to 30 parts of mulberry, 10 to 30 parts of medlar, 10 to 30 parts of dogwood, 10 to 30 parts of Chinese date, 1 to 2 parts of cervus elaphus linnaeus and 45 to 65 parts of rock candy.

Example two: the invention relates to a preparation method of a health wine

In the invention, the wine is prepared by the following method:

(1) weighing and cleaning: weighing the medicinal materials in proportion, washing with water, and draining for later use;

(2) soaking: placing herba Epimedii at bottom of soaking tank, placing the rest materials on the soaking tank, adding 4 times of 65% Chinese liquor, soaking for 4-6 hr, circulating for 15-25 days, filtering, and storing the filtrate in a storage tank; adding 45% white spirit in an amount which is 2.5 times the volume of the soaking tank, soaking for 4-6 hours every day during the soaking period, filtering after 10-20 days, and placing the filtrate in a storage tank; adding purified water with the volume of 1.0 time for circulating for 2 hours, filtering, and placing filtrate in a storage tank;

(3) and (3) filtering: standing the liquor obtained by soaking for 3 times for 10-20 days, and filtering the supernatant with diatomaceous earth filter with diatomaceous earth dosage of 1kg diatomaceous earth/1 ton liquor respectively;

(4) blending: mixing the filtrates in the storage tank, adding purified water to obtain 36.5% wine, adding crystal sugar according to formula proportion, stirring and dissolving;

(5) storing wine: putting the liquor into a storage tank, standing at low temperature for 30 days after passing sensory inspection and alcohol degree inspection, filtering, inspecting physical and chemical indexes, and preparing for filling;

(6) washing bottles and sterilizing: selecting qualified glass bottles and bottle caps, roughly washing the glass bottles with drinking water, finely washing the glass bottles with purified water, immediately drying, sterilizing and cooling for later use, roughly washing the bottle caps with the drinking water, finely washing the glass bottles with the purified water, soaking the glass bottles in 75% ethanol for 2 hours for sterilization, and drying for later use;

Example three: the invention relates to a health wine

The wine of the invention comprises 40kg of cistanche, 30kg of epimedium, 20kg of mulberry, 20kg of medlar, 20kg of dogwood, 20kg of Chinese date, 1kg of cervus elaphus linnaeus and 55kg of rock candy.

Example four: the invention relates to a health wine

In the invention, the wine comprises 20kg of cistanche, 20kg of epimedium, 10kg of mulberry, 10kg of medlar, 10kg of dogwood, 10kg of Chinese date, 1kg of cervus elaphus linnaeus and 45kg of rock sugar.

Example five: the invention relates to a health wine

In the invention, the wine comprises 60kg of cistanche, 40kg of epimedium, 30kg of mulberry, 30kg of medlar, 30kg of dogwood, 30kg of Chinese date, 2kg of cervus elaphus linnaeus and 65kg of rock sugar.

Example six: the invention relates to a preparation method of a health wine

In the invention, the liquor soaked in the tank circulates for 6 hours every day during the liquor soaking period, the liquor is filtered after 25 days, and the filtrate is placed in a storage tank; circulating for 6 hours every day after the white spirit is put into the soaking tank, filtering after 20 days, and putting the filtrate into a storage tank; adding purified water with the volume of 1.0 time for circulating for 2 hours, filtering, and placing filtrate in a storage tank; standing the liquor obtained by 3 times soaking for 20 days, and filtering the supernatant with diatomaceous earth filter.

Example seven: the component response surface method of the health care wine is optimized

1. Experimental Material

1.1 Experimental animals and raising

SPF grade male ICR mice, weight 19 ~ 22 g.

1.2 Main instruments

SBA-biosensing analyzer, Orlinbas AU400 model automatic biochemical analyzer, VIS-7200 visible spectrophotometer, homogenizer, centrifuge, and electronic balance.

1.3 samples

According to the requirements of a wine agent response surface method, experiment proportions are drawn up, and cistanche, epimedium, mulberry, medlar, dogwood, Chinese date, cervus elaphus linnaeus and rock candy are prepared to prepare the wine agent according to the preparation method of the sixth embodiment. The recommended adult amount according to the invention is 100ml/d, and the adult weight is 60kg, namely 1.67ml/kg. During the experiment, 10 times of concentrated solution is mixed with 50-degree base wine provided by manufacturers to prepare application solutions with different dosages for gastric perfusion, and the final alcohol concentration in each application solution is 15 degrees (15%, V/V, 20 ℃).

2 method of experiment

2.1 dose selection

Experimental animals were randomly divided into a blank control group, 120 test groups of the invention and a sugar control group. The test group of the invention is gavage with 1.67ml/kg. bw, the blank control group of animals is gavage with distilled water, the sugar control group is gavage with 20g/100ml of white granulated sugar solution with corresponding dose, once a day, and the experiment is carried out after continuous gavage for 30 days.

2.2 Experimental procedures

2.2.1 weight swimming experiment: 30min after the last administration of the test substance, the mice with 5% weight lead skin on their tails were placed in a swimming box for swimming. The water depth in the tank is more or less than 30cm, the water temperature is 25 +/-1 ℃, and the time from swimming to death of the mouse is recorded.

2.2.2 blood lactic acid assay: after the test object is given for 30min at the last time, the animal is placed in water with the temperature of 30 ℃ for swimming for 10min without load, and 20 mu L of eyeball blood is respectively collected before, immediately after and after swimming for 20min to measure the content of lactic acid. And calculating the area under the blood lactic acid curve according to the following formula to judge the blood lactic acid change condition after exercise. The area under the blood lactic acid curve is 5 x (the blood lactic acid value before swimming +3 x the blood lactic acid value after swimming + 0min the blood lactic acid value after 2 x the blood lactic acid value after swimming + 20min the blood lactic acid value after resting), the area of any test group is smaller than that of the sugar control group, the difference is significant, and the test result can be judged to be positive.

2.2.3 serum Urea Nitrogen determination: after the test object is given for 30min at the last time, the mouse is placed in water with the temperature of 30 ℃ for swimming for 90min without load, eyeball blood is collected for 0.5mL after the mouse is rested for 60min, and blood serum is collected after blood coagulation and is used for measuring the content of the urea nitrogen in the blood serum by an olympus AU400 type automatic biochemical analyzer.

2.2.4 liver glycogen assay: the animals were sacrificed 30min after the last administration of the test substance, the livers were rinsed with physiological saline and then blotted dry with filter paper, 100mg of the livers were quickly weighed, and the glycogen content of the livers was measured (anthrone method).

3. Analysis of Experimental data

Compared with a blank control group, the test group data has the advantages that the weight influence is less than 5%, the swimming time is improved by 25%, the blood lactic acid is positive, the serum urea nitrogen content is reduced by 40%, the liver glycogen content is increased by 10%, the curative effect is achieved, the response surface method analysis optimization is carried out according to the statistics of the curative ratio of each test group, and the optimization result is shown in the attached drawing of the specification and the following data.

The optimization process of the response surface method on the process parameters is as follows:

table 1: response surface factor level meter

Table 2: design result of Box-bohnken experiment

The response surface method optimization experiment result shows that the secondary items of the cistanche, the epimedium, the mulberry, the medlar, the dogwood, the Chinese date, the cervus elaphus linnaeus and the rock sugar have obvious significance on the final curative effect of the health-care wine to achieve the same degree of curative effect. If the content of a certain component is excessive, the drug effect of the whole wine is reduced, because chronic fatigue syndrome is a comprehensive disease, the pathogenic causes are multiple, the regulation principle is complex, different pharmacological conditioning is needed according to the traditional Chinese medicine symptoms such as qi and blood deficiency type, liver depression and spleen deficiency type, heart and spleen deficiency type, liver and kidney deficiency type, heart and kidney imbalance type and the like of the traditional Chinese medicine principle, the formula of the wine is just based on the consideration of various pathogenic factors, the medicine is monarch and ministerial medicine, and is mutually assisted by different pathogenic factors, the treatment effect is finally achieved, the optimal combination is cistanche 40g, epimedium 30g, mulberry 20g, medlar 20g, dogwood 20g, Chinese date 20g, hairy antler 1.5g and rock sugar 55g, the treatment effect is the best, and the treatment rate is close to 92 percent.

Example eight: evaluation of taste of the health wine of the invention

The health-care wine formula is optimized by adopting a response surface method, and as the wine is used as a beverage, particularly as wine which needs to be taken for a long time for treating chronic fatigue syndrome, the taste is important, 10 white wine evaluators with white wine evaluation experience and evaluation qualification are invited by an applicant, and the appearance, the fragrance and the taste of the medicinal wine prepared by the method are comprehensively evaluated in a sensory mode. The full score of the sensory evaluation is 100, the appearance score is 15, wherein the clarity is 5, and the color is 10; analyzing and evaluating the whole smell of the wine by fragrance analysis, wherein the score is divided into full points by 30, the purity of the smell is 15 points, and the fragrance amount is 15 points; the taste analysis is divided into full score according to 44, the sour and sweet degree is evaluated for 20, the wine taste is pure, and the wine body is complete for 24; the overall perception evaluation mainly comprises the evaluation of the aroma and the flavor of the wine and the overall perception of wine evaluators, wherein the full score is 11, the evaluation results are counted and shown in the following table.

Table 3: the sensory evaluation result of the wine of the invention

The taste evaluation result shows that the medicinal liquor disclosed by the invention is crystal and transparent in color, free of suspended matters and precipitate, has elegant and harmonious compound aroma with ethyl acetate as a main body, is pure and pure in faint scent, moderate in aroma amount, sweet and mellow in taste, harmonious in aroma, refreshing and clean in taste, moderate in sweetness, but has a certain medicinal taste, and is outstanding and typical in style and suitable for long-term administration.

As described above, the present invention can be preferably implemented, and the above-mentioned embodiments only describe the preferred embodiments of the present invention, and do not limit the scope of the present invention, and various modifications and improvements made to the technical solution of the present invention by those skilled in the art without departing from the design spirit of the present invention should fall within the protection scope determined by the present invention.

Claims

1. A health wine is characterized by being prepared by the following method:

(1) weighing and cleaning: weighing 40 parts of cistanche, 30 parts of epimedium, 20 parts of mulberry, 20 parts of medlar, 20 parts of dogwood, 20 parts of Chinese date and 1 part of cervus elaphus linnaeus, washing with water, and draining for later use;

(4) blending: uniformly mixing the filtrate in the storage tank, adding purified water to prepare 36.5% wine, adding 55 parts of rock sugar according to the formula proportion, stirring and dissolving for later use;

2. The health wine according to claim 1, wherein the wine soaking in the tank during the wine soaking period is circulated for 6 hours per day, and after 25 days, the wine is filtered and the filtrate is stored in the storage tank; circulating for 6 hours every day after the white spirit is put into the soaking tank, filtering after 20 days, and putting the filtrate into a storage tank; adding purified water with the volume of 1.0 time for circulating for 2 hours, filtering, and placing filtrate in a storage tank; standing the liquor obtained by 3 times soaking for 20 days, and filtering the supernatant with diatomaceous earth filter.