CN112587621A - Medicine for resisting myocardial ischemic diseases and preparation method thereof - Google Patents
Medicine for resisting myocardial ischemic diseases and preparation method thereof Download PDFInfo
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Abstract
The invention belongs to the technical field of medicine preparation, and discloses a medicine for resisting myocardial ischemia diseases and a preparation method thereof, wherein the medicine for resisting myocardial ischemia diseases comprises, by mass, 20-30 parts of salvia miltiorrhiza, 15-20 parts of lophatherum gracile total flavonoids, 10-15 parts of safflower, 8-12 parts of common andrographis herbs, 6-9 parts of angelica sinensis, 4-8 parts of ginkgo leaves, 5-7 parts of ligusticum wallichii, 2-3 parts of coptis chinensis, 4-6 parts of houttuynia cordata, 3-6 parts of bezoar, 1-3 parts of borneol, and 5-8 parts of dendrobium officinale. According to the invention, by adding the medicinal materials such as salvia miltiorrhiza, lophatherum gracile general flavone, safflower, andrographis paniculata, angelica, ginkgo leaves, ligusticum wallichii, coptis chinensis and the like, the effects of promoting blood circulation and removing blood stasis can be realized, platelet aggregation and thrombosis resistance are reduced, the link of myocardial ischemia symptoms is realized, the discomfort of heart parts is reduced, and the treatment of myocardial ischemia can be realized after long-term administration. The medicine of the invention has reasonable proportion and simple preparation method, and can realize the treatment of myocardial ischemic diseases.
Description
Technical Field
The invention belongs to the technical field of medicine preparation, and particularly relates to a medicine for resisting myocardial ischemia diseases and a preparation method thereof.
Background
Currently, myocardial ischemia (myocardial ischemia) refers to a pathological condition in which the blood perfusion of the heart is reduced, so that the oxygen supply of the heart is reduced, the energy metabolism of the heart muscle is abnormal, and the heart cannot work normally.
The energy required by the heart activity is almost completely provided by aerobic metabolism, so even in quiet, the blood oxygen intake rate of the cardiac muscle is very high (about 70%), and under normal conditions, the body can regulate by itself to promote the blood supply and demand to be relatively constant, thereby ensuring the normal work of the heart; when the supply and demand of myocardial blood are unbalanced for some reason, myocardial ischemia is really formed; coronary heart disease is the most prominent and common cause of myocardial ischemia. The reasons for myocardial ischemia are many, blood pressure is reduced, blood supply of aorta is reduced, and coronary artery obstruction can directly cause blood supply reduction of heart; valvular heart disease, changes in blood viscosity, and myocardial lesions also reduce blood supply to the heart; the most common causes of these are atherosclerosis of the coronary arteries, followed by a variety of inflammations (rheumatic, syphilitic, kawasaki disease, and vasoocclusive vasculitis), spasms, emboli, connective tissue disease, trauma, and congenital malformations. The existing medicines for treating acute and chronic myocardial ischemic diseases are many, but the existing medicines are single in component, the treatment effect is not obvious, and the medicine effect is not maintained for a long time.
Through the above analysis, the problems and defects of the prior art are as follows: the existing medicines for treating acute and chronic myocardial ischemic diseases are many, but the existing medicines are single in component, the treatment effect is not obvious, and the medicine effect is not maintained for a long time.
Disclosure of Invention
Aiming at the problems in the prior art, the invention provides a medicament for resisting myocardial ischemic diseases and a preparation method thereof.
The invention is realized in such a way that the preparation method of the anti-myocardial ischemic disease medicament comprises the following steps:
step one, weighing salvia miltiorrhiza, lophatherum gracile total flavonoids, safflower, common andrographis herb, Chinese angelica, ginkgo leaves, ligusticum wallichii, coptis chinensis, houttuynia cordata, bezoar, borneol and dendrobium officinale according to parts by weight, respectively cleaning with clean water, and cleaning surface impurities;
step two, placing the salvia miltiorrhiza in a drying box, setting the drying temperature to be 70-85 ℃ and the drying time to be 10-20 min for drying, placing the dried salvia miltiorrhiza in a grinder for grinding, and placing the ground salvia miltiorrhiza particles in a grinder for grinding to obtain salvia miltiorrhiza powder;
step three, taking fresh lophatherum gracile, cleaning, drying, putting into an extraction tank, adding 5-10 times of water, heating and refluxing for 2-4 times, filtering, combining extracting solutions, and concentrating to obtain a water extracting solution of the lophatherum gracile; adding ethanol into the lophatherum gracile water extract to enable the concentration of the ethanol in the lophatherum gracile water extract to reach 65-75%, standing for precipitation, filtering, and concentrating to obtain an ethanol precipitation solution of the lophatherum gracile water extract for later use; taking the lophatherum gracile alcohol precipitation solution, passing through a macroporous resin column, eluting, detecting by thin-layer chromatography, collecting 50-55% ethanol eluate, concentrating, and drying under reduced pressure to obtain total flavonoids in lophatherum gracile;
step four, mixing the common andrographis herb, the Chinese angelica, the ligusticum wallichii, the bezoar and the borneol, placing the mixture into a marmite, adding clear water into the marmite to submerge the medicinal materials, and soaking for 6-8 hours; after soaking, carrying out first decoction together with the soaking solution, and filtering to obtain a first filtrate;
step five, adding safflower into the filter residue obtained by filtering, uniformly mixing the safflower with the filter residue, adding clear water into the marmite to submerge the filter residue, carrying out second decoction, and filtering to obtain a second filtrate; mixing the primary filtrate and the secondary filtrate, standing for 1-2 h, cooling and removing bottom precipitates to obtain a mixed liquid medicine; carrying out reduced pressure condensation on the mixed liquid medicine to obtain concentrated solution;
sixthly, airing the cleaned coptis until the water content is less than 5%; putting the aired coptis into a grinder, and grinding the coptis into mud residue; soaking the sludge-shaped coptis in an ethanol solution for 1-2 days; putting the soaked coptis into a spin dryer for spin-drying, and collecting separated liquid; heating the collected liquid, and volatilizing ethanol to obtain Coptidis rhizoma extract;
step seven, rolling the ginkgo leaves, and placing the rolled ginkgo leaves in an extraction device; adding 70% ethanol with mass concentration 30 times of that of folium Ginkgo into the extraction device; heating and extracting for 4-5 h; after extraction, standing and precipitating, and taking supernatant liquid, namely the ginkgo leaf extract, after 10-12 hours;
step eight, respectively preparing a houttuynia cordata extract and a dendrobium officinale extract from houttuynia cordata and dendrobium officinale, mixing the concentrated solution with a coptis chinensis extract, a ginkgo leaf extract, a houttuynia cordata extract and a dendrobium officinale extract, adding red sage root powder and lophatherum gracile total flavonoids, and uniformly stirring to obtain a medicinal stock solution;
and step nine, adding starch into the drug stock solution, stirring uniformly, adding magnesium stearate, and placing in a granulator for granulation to obtain the anti-myocardial ischemic disease drug.
Further, in the second step, the particle size of the salvia miltiorrhiza powder is 0.1-0.2 mm.
Further, in step three, the elution method comprises: eluting with water and ethanol with the concentration of 10% respectively, and then eluting with ethanol with the concentration of 50-55%.
Further, in the fourth step, in the first decoction, the decoction is carried out for 20-50 min with strong fire and the decoction is carried out for 2-3 h with small fire.
Further, in the sixth step, the mass concentration of the ethanol solution is 75%.
Further, in step eight, the preparation of the houttuynia cordata extract by using the houttuynia cordata comprises the following steps:
(1) putting the houttuynia cordata into a grinder to be ground to obtain houttuynia cordata fragments;
(2) mixing the minced houttuynia cordata with purified water, and fully soaking until the minced houttuynia cordata absorbs water and expands; heating the mixture of the houttuynia cordata and the water, and preserving heat for 1-2 hours;
(3) and after the heat preservation is finished, cooling the mixture of the houttuynia cordata and the water to room temperature, and filtering out houttuynia cordata scraps to obtain the houttuynia cordata extract.
Further, in the eighth step, the preparation of the dendrobium officinale extract by using the dendrobium officinale comprises the following steps:
(1) drying Dendrobium officinale in the sun, placing in a temperature changing box, rapidly cooling to 0 ℃, and carrying out low-temperature stress treatment;
(2) after the low-temperature stress treatment is finished, decompressing the temperature changing box;
(3) gradually heating the temperature changing box, and stopping heating after the temperature is increased to the room temperature;
(4) extracting effective substances in the dendrobium officinale to obtain the dendrobium officinale extract.
Further, in the eighth step, the extraction of the effective substances in the dendrobium officinale comprises:
the dendrobium officinale is crushed into 80-100-mesh particles, heated and extracted for 2-3 hours by using water with the weight 10-15 times that of the dendrobium officinale, and the dendrobium officinale extract is obtained through reduced pressure concentration.
The invention also aims to provide the myocardial ischemic disease resistant medicine prepared by the preparation method of the myocardial ischemic disease resistant medicine, wherein the myocardial ischemic disease resistant medicine is composed of, by mass, 20-30 parts of salvia miltiorrhiza, 15-20 parts of lophatherum gracile general flavone, 10-15 parts of safflower, 8-12 parts of andrographis paniculata, 6-9 parts of angelica sinensis, 4-8 parts of ginkgo leaves, 5-7 parts of ligusticum wallichii, 2-3 parts of coptis chinensis, 4-6 parts of houttuynia cordata, 3-6 parts of bezoar, 1-3 parts of borneol and 5-8 parts of dendrobium officinale.
Further, the lophatherum gracile total flavonoids comprise orientin, isoorientin, swertisin, vitexin, isovitexin, luteolin and medicagine.
By combining all the technical schemes, the invention has the advantages and positive effects that: according to the invention, the effects of promoting blood circulation and removing blood stasis can be realized by adding the salvia miltiorrhiza, the lophatherum gracile total flavonoids, the safflower, the andrographis paniculata, the angelica, the ginkgo leaves, the ligusticum wallichii, the coptis chinensis, the houttuynia cordata, the bezoar, the borneol and the dendrobium officinale, the link of myocardial ischemia symptoms is realized, the discomfort of heart parts is reduced, and the treatment of myocardial ischemia can be realized by long-term administration. The medicine of the invention has reasonable proportion and simple preparation method, and can realize the treatment of myocardial ischemic diseases.
Wherein, Dan Shen is bitter in flavor and slightly cold in nature. Meridian tropism enters heart and liver meridians. The functions are mainly used for removing blood stasis, relieving pain, promoting blood circulation, stimulating the menstrual flow, clearing away the heart fire and relieving restlessness. Can be used for treating menoxenia, amenorrhea, dysmenorrhea, abdominal mass, thoracico-abdominal pain, arthralgia due to heat, pyocutaneous disease, swelling and pain, vexation, and insomnia; hepatosplenomegaly, angina pectoris. The safflower has pungent and nontoxic properties and taste; it is mainly used for postpartum anemic fainting and unexhausted abdominal lochiorrhea.
The folium Bambusae total flavone has various biological activities, including cardiovascular system activity, antibacterial and antiviral activity, antitumor activity, antioxidant free radical activity, antiinflammatory, analgesic activity, liver protecting activity, blood pressure lowering, blood lipid reducing, antiaging, immunity improving, purgative, antitussive, phlegm eliminating, spasmolytic and antiallergic pharmacological activities.
Andrographis paniculata Nees has the effects of clearing away heat and toxic materials, cooling blood and relieving swelling. Can be used for treating common cold, fever, sore throat, aphtha, cough, diarrhea, dysentery, stranguria, carbuncle, suppurative sore, and snake bite.
Dang Gui is sweet, pungent and warm in nature. Meridian tropism enters liver, heart and spleen meridians. The functions of the medicine are mainly replenishing blood and activating blood, regulating menstruation and relieving pain, and relaxing bowel. Can be used for treating blood deficiency, sallow complexion, giddiness, palpitation, menoxenia, amenorrhea, dysmenorrhea, asthenia cold, abdominal pain, constipation due to intestinal dryness, rheumatic arthralgia, traumatic injury, superficial infection, pyocutaneous disease. The wine angelica sinensis can activate blood and promote menstruation. Can be used for treating amenorrhea, dysmenorrhea, rheumatalgia, and traumatic injury.
Ginkgo leaves are sweet, bitter, astringent and neutral in nature and taste. Meridian tropism is heart meridian and lung meridian. The functions are mainly used for astringing lung, relieving asthma, promoting blood circulation by removing blood stasis and relieving pain. Can be used for treating cough and asthma due to lung deficiency; coronary heart disease, angina pectoris, and hyperlipidemia.
Chuan Xiong is pungent in flavor and warm in nature. Meridian tropism enters liver, gallbladder and pericardium. The functions are mainly used for activating blood and promoting qi circulation, and dispelling wind and relieving pain. Can be used for treating menoxenia, amenorrhea, dysmenorrhea, abdominal pain, pricking pain in chest and hypochondrium, traumatic injury, swelling and pain, headache, and rheumatalgia.
Huang Lian is bitter in flavor and cold in nature. The meridian entered heart, spleen, stomach, liver, gallbladder and large intestine. The functions are mainly used for clearing heat and drying dampness, purging fire and removing toxin. Can be used for treating damp-heat distention, fullness, emesis, acid regurgitation, dysentery, jaundice, hyperpyrexia, coma, excessive heart-fire, vexation, insomnia, hematemesis, hemorrhage, conjunctival congestion, toothache, diabetes, carbuncle, furuncle, etc.; it is used externally to treat eczema, eczema and purulent ear canal. Huang Lian (Chinese goldthread) processed with wine is good at clearing heat in upper energizer. It can be used for treating conjunctival congestion and aphtha. Jiang Huang Lian can clear stomach, harmonize stomach and stop vomiting. Can be used for treating cold and heat accumulation, damp-heat obstruction, fullness and emesis. Yu Huang Lian soothes liver, harmonizes stomach and stops vomiting. Can be used for treating liver and stomach disharmony, emesis and acid regurgitation.
The cordate houttuynia is pungent in flavor and slightly cold in nature. Meridian tropism enters lung meridian. The functions are mainly to clear away heat and toxic material, cure carbuncle and discharge pus, induce diuresis and treat stranguria. Can be used for treating lung abscess with purulent vomiting, phlegm heat, cough and asthma, dysentery, pyretic stranguria, carbuncle, swelling, and sore.
Bezoar is sweet in nature and cool. Meridian tropism enters heart and liver meridians. The functions are mainly to clear away heart-fire, eliminate phlegm, induce resuscitation, cool liver, extinguish wind and remove toxicity. Can be used for treating fever unconsciousness, apoplexy with phlegm, convulsive epilepsy, convulsion, epilepsy, mania, sore throat, aphtha of the mouth and tongue, carbuncle, swelling, and furuncle.
Borneol is pungent, bitter and slightly cold in nature and flavor, and enters heart, spleen and lung meridians. The Borneolum has effects of inducing resuscitation, clearing heat, and relieving pain, and can be used for treating fever unconsciousness, convulsion, apoplexy, phlegm syncope, qi stagnation, syncope, coma, thoracic obstruction, cardiodynia, conjunctival congestion, aphtha, sore throat, and purulence in ear canal.
Dendrobium officinale is cold in nature, sweet, light and slightly salty in taste. The functions are mainly used for nourishing yin, clearing heat, promoting the production of body fluid and quenching thirst. Can be used for treating febrile disease, impairment of body fluid, thirst, dryness of tongue, asthenia heat after illness, gastropathy, retching, and glossless tongue fur.
Drawings
In order to more clearly illustrate the technical solutions of the embodiments of the present application, the drawings needed to be used in the embodiments of the present application will be briefly described below, and it is obvious that the drawings described below are only some embodiments of the present application, and it is obvious for those skilled in the art that other drawings can be obtained from the drawings without creative efforts.
FIG. 1 is a flow chart of a method for preparing a medicine for treating myocardial ischemic diseases according to an embodiment of the present invention.
FIG. 2 is a flow chart of a method for preparing an extract of Coptidis rhizoma using Coptidis rhizoma according to an embodiment of the present invention.
Fig. 3 is a flow chart of a method for preparing ginkgo biloba extract using ginkgo biloba leaves according to an embodiment of the present invention.
FIG. 4 is a flow chart of a method for preparing an extract of houttuynia cordata using houttuynia cordata according to an embodiment of the present invention.
Fig. 5 is a flowchart of a method for preparing an extract from dendrobium officinale according to an embodiment of the present invention.
Detailed Description
In order to make the objects, technical solutions and advantages of the present invention more apparent, the present invention is further described in detail with reference to the following embodiments. It should be understood that the specific embodiments described herein are merely illustrative of the invention and are not intended to limit the invention.
Aiming at the problems in the prior art, the invention provides a medicament for resisting myocardial ischemic diseases and a preparation method thereof, and the invention is described in detail below with reference to the accompanying drawings.
As shown in fig. 1, the preparation method of the anti-myocardial ischemic disease drug provided by the embodiment of the present invention comprises the following steps:
s101, weighing the salvia miltiorrhiza, the lophatherum gracile total flavonoids, the safflower, the andrographis paniculata, the angelica, the ginkgo leaves, the ligusticum wallichii, the coptis chinensis, the houttuynia cordata, the bezoar, the borneol and the dendrobium officinale according to the mass parts, respectively cleaning with clean water, and cleaning surface impurities;
s102, placing the salvia miltiorrhiza into a drying box, setting the drying temperature to be 70-85 ℃ and the drying time to be 10-20 min for drying, placing the dried salvia miltiorrhiza into a grinder for grinding, and placing the ground salvia miltiorrhiza particles into a grinder for grinding to obtain salvia miltiorrhiza powder;
s103, mixing common andrographis herb, Chinese angelica, ligusticum wallichii, bezoar and borneol, placing the mixture into a marmite, adding clear water into the marmite to submerge the medicinal materials, and soaking for 6-8 hours; after soaking, carrying out first decoction together with the soaking solution, and filtering to obtain a first filtrate;
s104, adding safflower into the filter residue obtained by filtering, uniformly mixing the safflower with the filter residue, adding clear water into the marmite to submerge the filter residue, carrying out second decoction, and filtering to obtain a second filtrate; mixing the primary filtrate and the secondary filtrate, standing for 1-2 h, cooling and removing bottom precipitates to obtain a mixed liquid medicine; carrying out reduced pressure condensation on the mixed liquid medicine to obtain concentrated solution;
s105, respectively using coptis chinensis, ginkgo leaves, houttuynia cordata and dendrobium officinale to prepare a coptis chinensis extract, a ginkgo leaf extract, a houttuynia cordata extract and a dendrobium officinale extract, and mixing the concentrated solution with the coptis chinensis extract, the ginkgo leaf extract, the houttuynia cordata extract and the dendrobium officinale extract to obtain a mixture;
s106, adding the salvia miltiorrhiza powder and the lophatherum gracile total flavonoids into the mixture, and uniformly stirring to obtain a medicine stock solution; adding starch into the raw liquid, stirring, adding magnesium stearate, and granulating in a granulator to obtain the medicine for resisting myocardial ischemia.
In step S102 provided in the embodiment of the present invention, the particle size of the salvia miltiorrhiza powder is 0.1 to 0.2 mm.
In step S102 provided in the embodiment of the present invention, the preparation method of the lophatherum gracile total flavonoids includes: cleaning and drying fresh lophatherum gracile, putting into an extraction tank, adding 5-10 times of water, heating and refluxing for 2-4 times, filtering, combining extracting solutions, and concentrating to obtain a water extracting solution of the lophatherum gracile; adding ethanol into the lophatherum gracile water extract to enable the concentration of the ethanol in the lophatherum gracile water extract to reach 65-75%, standing for precipitation, filtering, and concentrating to obtain an ethanol precipitation solution of the lophatherum gracile water extract for later use; and (3) putting the lophatherum gracile alcohol precipitation solution on a macroporous resin column, eluting, detecting by thin-layer chromatography, collecting 50-55% ethanol eluate, concentrating, and drying under reduced pressure to obtain the total flavonoids in the lophatherum gracile.
The elution method provided by the embodiment of the invention comprises the following steps: eluting with water and ethanol with the concentration of 10% respectively, and then eluting with ethanol with the concentration of 50-55%.
In the step S103 provided by the embodiment of the invention, in the first decoction, the decoction is carried out for 20-50 min with strong fire and the decoction is carried out for 2-3 h with small fire.
As shown in fig. 2, in step S105, the preparation of the coptis chinensis extract using coptis chinensis according to the embodiment of the present invention includes:
s201, airing the cleaned coptis until the water content is less than 5%;
s202, putting the aired coptis into a grinder, grinding the coptis into mud residue, and soaking the mud residue in an ethanol solution for 1-2 days;
s203, putting the soaked coptis into a spin dryer for spin-drying, and collecting separated liquid;
s204, heating the collected liquid, and volatilizing ethanol to obtain the coptis chinensis extract.
In step S202 provided in the embodiment of the present invention, the mass concentration of the ethanol solution is 75%.
As shown in fig. 3, in step S105, the preparation of the ginkgo biloba extract using ginkgo biloba leaves according to the embodiment of the present invention includes:
s301, grinding the ginkgo leaves, and placing the ground ginkgo leaves in an extraction device;
s302, adding ethanol with the mass concentration of 70% which is 30 times that of the ginkgo leaves into an extraction device;
s303, heating and extracting for 4-5 hours;
s304, after extraction is finished, standing and precipitating, and taking supernatant liquor after 10-12 hours, namely the ginkgo leaf extract.
As shown in fig. 4, in step S105, the preparation of the extract of houttuynia cordata by using houttuynia cordata according to the embodiment of the present invention includes:
s401, putting the houttuynia cordata into a grinder to be ground to obtain houttuynia cordata fragments;
s402, mixing the houttuynia cordata fragments with purified water, and fully soaking until the houttuynia cordata fragments absorb water and expand;
s403, heating the mixture of the houttuynia cordata and the water, and keeping the temperature for 1-2 hours;
s404, after the heat preservation is finished, cooling the mixture of the houttuynia cordata and the water to room temperature, and filtering out houttuynia cordata scraps to obtain the houttuynia cordata extract.
As shown in fig. 5, in step S105, the preparation of the dendrobium officinale extract by using dendrobium officinale includes:
s501, drying the dendrobium officinale in the air, placing the dried dendrobium officinale in a temperature changing box, rapidly cooling to 0 ℃, and carrying out low-temperature stress treatment;
s502, after the low-temperature stress treatment is finished, decompressing the temperature changing box;
s503, gradually heating the temperature changing box to room temperature, and stopping heating;
s504, extracting effective substances in the dendrobium officinale to obtain the dendrobium officinale extract.
In step S504 provided by the embodiment of the present invention, extracting effective substances from dendrobium officinale includes: the dendrobium officinale is crushed into 80-100-mesh particles, heated and extracted for 2-3 hours by using water with the weight 10-15 times that of the dendrobium officinale, and the dendrobium officinale extract is obtained through reduced pressure concentration.
The medicine for resisting myocardial ischemia diseases comprises, by mass, 20-30 parts of salvia miltiorrhiza, 15-20 parts of lophatherum gracile total flavonoids, 10-15 parts of safflower, 8-12 parts of common andrographis herbs, 6-9 parts of angelica sinensis, 4-8 parts of ginkgo leaves, 5-7 parts of ligusticum wallichii, 2-3 parts of coptis chinensis, 4-6 parts of houttuynia cordata, 3-6 parts of bezoar, 1-3 parts of borneol and 5-8 parts of dendrobium officinale.
The lophatherum gracile total flavonoids provided by the embodiment of the invention comprise: orientin, isoorientin, swertisin, vitexin, isovitexin, luteolin and medicagine.
The invention is further described below in connection with pharmacological assays.
Dan Shen is bitter in flavor and slightly cold in nature. Meridian tropism enters heart and liver meridians. The functions are mainly used for removing blood stasis, relieving pain, promoting blood circulation, stimulating the menstrual flow, clearing away the heart fire and relieving restlessness. Can be used for treating menoxenia, amenorrhea, dysmenorrhea, abdominal mass, thoracico-abdominal pain, arthralgia due to heat, pyocutaneous disease, swelling and pain, vexation, and insomnia; hepatosplenomegaly, angina pectoris. The safflower has pungent and nontoxic properties and taste; it is mainly used for postpartum anemic fainting and unexhausted abdominal lochiorrhea.
The folium Bambusae total flavone has various biological activities, including cardiovascular system activity, antibacterial and antiviral activity, antitumor activity, antioxidant free radical activity, antiinflammatory, analgesic activity, liver protecting activity, blood pressure lowering, blood lipid reducing, antiaging, immunity improving, purgative, antitussive, phlegm eliminating, spasmolytic and antiallergic pharmacological activities.
Andrographis paniculata Nees has the effects of clearing away heat and toxic materials, cooling blood and relieving swelling. Can be used for treating common cold, fever, sore throat, aphtha, cough, diarrhea, dysentery, stranguria, carbuncle, suppurative sore, and snake bite.
Dang Gui is sweet, pungent and warm in nature. Meridian tropism enters liver, heart and spleen meridians. The functions of the medicine are mainly replenishing blood and activating blood, regulating menstruation and relieving pain, and relaxing bowel. Can be used for treating blood deficiency, sallow complexion, giddiness, palpitation, menoxenia, amenorrhea, dysmenorrhea, asthenia cold, abdominal pain, constipation due to intestinal dryness, rheumatic arthralgia, traumatic injury, superficial infection, pyocutaneous disease. The wine angelica sinensis can activate blood and promote menstruation. Can be used for treating amenorrhea, dysmenorrhea, rheumatalgia, and traumatic injury.
Ginkgo leaves are sweet, bitter, astringent and neutral in nature and taste. Meridian tropism is heart meridian and lung meridian. The functions are mainly used for astringing lung, relieving asthma, promoting blood circulation by removing blood stasis and relieving pain. Can be used for treating cough and asthma due to lung deficiency; coronary heart disease, angina pectoris, and hyperlipidemia.
Chuan Xiong is pungent in flavor and warm in nature. Meridian tropism enters liver, gallbladder and pericardium. The functions are mainly used for activating blood and promoting qi circulation, and dispelling wind and relieving pain. Can be used for treating menoxenia, amenorrhea, dysmenorrhea, abdominal pain, pricking pain in chest and hypochondrium, traumatic injury, swelling and pain, headache, and rheumatalgia.
Huang Lian is bitter in flavor and cold in nature. The meridian entered heart, spleen, stomach, liver, gallbladder and large intestine. The functions are mainly used for clearing heat and drying dampness, purging fire and removing toxin. Can be used for treating damp-heat distention, fullness, emesis, acid regurgitation, dysentery, jaundice, hyperpyrexia, coma, excessive heart-fire, vexation, insomnia, hematemesis, hemorrhage, conjunctival congestion, toothache, diabetes, carbuncle, furuncle, etc.; it is used externally to treat eczema, eczema and purulent ear canal. Huang Lian (Chinese goldthread) processed with wine is good at clearing heat in upper energizer. It can be used for treating conjunctival congestion and aphtha. Jiang Huang Lian can clear stomach, harmonize stomach and stop vomiting. Can be used for treating cold and heat accumulation, damp-heat obstruction, fullness and emesis. Yu Huang Lian soothes liver, harmonizes stomach and stops vomiting. Can be used for treating liver and stomach disharmony, emesis and acid regurgitation.
The cordate houttuynia is pungent in flavor and slightly cold in nature. Meridian tropism enters lung meridian. The functions are mainly to clear away heat and toxic material, cure carbuncle and discharge pus, induce diuresis and treat stranguria. Can be used for treating lung abscess with purulent vomiting, phlegm heat, cough and asthma, dysentery, pyretic stranguria, carbuncle, swelling, and sore.
Bezoar is sweet in nature and cool. Meridian tropism enters heart and liver meridians. The functions are mainly to clear away heart-fire, eliminate phlegm, induce resuscitation, cool liver, extinguish wind and remove toxicity. Can be used for treating fever unconsciousness, apoplexy with phlegm, convulsive epilepsy, convulsion, epilepsy, mania, sore throat, aphtha of the mouth and tongue, carbuncle, swelling, and furuncle.
Borneol is pungent, bitter and slightly cold in nature and flavor, and enters heart, spleen and lung meridians. The Borneolum has effects of inducing resuscitation, clearing heat, and relieving pain, and can be used for treating fever unconsciousness, convulsion, apoplexy, phlegm syncope, qi stagnation, syncope, coma, thoracic obstruction, cardiodynia, conjunctival congestion, aphtha, sore throat, and purulence in ear canal.
Dendrobium officinale is cold in nature, sweet, light and slightly salty in taste. The functions are mainly used for nourishing yin, clearing heat, promoting the production of body fluid and quenching thirst. Can be used for treating febrile disease, impairment of body fluid, thirst, dryness of tongue, asthenia heat after illness, gastropathy, retching, and glossless tongue fur.
The technical solution of the present invention is further described with reference to the following specific examples.
Example 1:
case one:
plum, male, and 68 years old, and the detection result shows that coronary atherosclerosis and blood vessel narrowing are caused by admission examination of heart diseases; the medicine is used for treatment, the heart discomfort disappears after two months, and the blood pressure and the blood oxygen are normal.
Case two:
in the past, the patients of 31 years old feel the symptoms of chest distress and palpitation, and then are examined in a hospital to confirm that the patients are diagnosed with myocardial ischemia, which is often accompanied with discomfort and pain of heart parts; the medicine has no pain problem and can relieve myocardial ischemia.
The above description is only for the purpose of illustrating the preferred embodiments of the present invention, and the scope of the present invention is not limited thereto, and any modification, equivalent replacement, and improvement made by those skilled in the art within the technical scope of the present invention disclosed herein, which is within the spirit and principle of the present invention, should be covered by the present invention.
Claims (10)
1. A preparation method of a medicine for resisting myocardial ischemic diseases is characterized by comprising the following steps:
step one, weighing salvia miltiorrhiza, lophatherum gracile total flavonoids, safflower, common andrographis herb, Chinese angelica, ginkgo leaves, ligusticum wallichii, coptis chinensis, houttuynia cordata, bezoar, borneol and dendrobium officinale according to parts by weight, respectively cleaning with clean water, and cleaning surface impurities;
step two, placing the salvia miltiorrhiza in a drying box, setting the drying temperature to be 70-85 ℃ and the drying time to be 10-20 min for drying, placing the dried salvia miltiorrhiza in a grinder for grinding, and placing the ground salvia miltiorrhiza particles in a grinder for grinding to obtain salvia miltiorrhiza powder;
step three, taking fresh lophatherum gracile, cleaning, drying, putting into an extraction tank, adding 5-10 times of water, heating and refluxing for 2-4 times, filtering, combining extracting solutions, and concentrating to obtain a water extracting solution of the lophatherum gracile; adding ethanol into the lophatherum gracile water extract to enable the concentration of the ethanol in the lophatherum gracile water extract to reach 65-75%, standing for precipitation, filtering, and concentrating to obtain an ethanol precipitation solution of the lophatherum gracile water extract for later use; taking the lophatherum gracile alcohol precipitation solution, passing through a macroporous resin column, eluting, detecting by thin-layer chromatography, collecting 50-55% ethanol eluate, concentrating, and drying under reduced pressure to obtain total flavonoids in lophatherum gracile;
step four, mixing the common andrographis herb, the Chinese angelica, the ligusticum wallichii, the bezoar and the borneol, placing the mixture into a marmite, adding clear water into the marmite to submerge the medicinal materials, and soaking for 6-8 hours; after soaking, carrying out first decoction together with the soaking solution, and filtering to obtain a first filtrate;
step five, adding safflower into the filter residue obtained by filtering, uniformly mixing the safflower with the filter residue, adding clear water into the marmite to submerge the filter residue, carrying out second decoction, and filtering to obtain a second filtrate; mixing the primary filtrate and the secondary filtrate, standing for 1-2 h, cooling and removing bottom precipitates to obtain a mixed liquid medicine; carrying out reduced pressure condensation on the mixed liquid medicine to obtain concentrated solution;
sixthly, airing the cleaned coptis until the water content is less than 5%; putting the aired coptis into a grinder, and grinding the coptis into mud residue; soaking the sludge-shaped coptis in an ethanol solution for 1-2 days; putting the soaked coptis into a spin dryer for spin-drying, and collecting separated liquid; heating the collected liquid, and volatilizing ethanol to obtain Coptidis rhizoma extract;
step seven, rolling the ginkgo leaves, and placing the rolled ginkgo leaves in an extraction device; adding 70% ethanol with mass concentration 30 times of that of folium Ginkgo into the extraction device; heating and extracting for 4-5 h; after extraction, standing and precipitating, and taking supernatant liquid, namely the ginkgo leaf extract, after 10-12 hours;
step eight, respectively preparing a houttuynia cordata extract and a dendrobium officinale extract from houttuynia cordata and dendrobium officinale, mixing the concentrated solution with a coptis chinensis extract, a ginkgo leaf extract, a houttuynia cordata extract and a dendrobium officinale extract, adding red sage root powder and lophatherum gracile total flavonoids, and uniformly stirring to obtain a medicinal stock solution;
and step nine, adding starch into the drug stock solution, stirring uniformly, adding magnesium stearate, and placing in a granulator for granulation to obtain the anti-myocardial ischemic disease drug.
2. The method for preparing a medicament for treating myocardial ischemic diseases according to claim 1, wherein in the second step, the particle size of the powder of Salvia miltiorrhiza is 0.1 to 0.2 mm.
3. The method for preparing a myocardial ischemic disease-resistant drug according to claim 1, wherein in step three, the elution method comprises: eluting with water and ethanol with the concentration of 10% respectively, and then eluting with ethanol with the concentration of 50-55%.
4. The method for preparing a medicament for treating myocardial ischemic diseases according to claim 1, wherein in the fourth step, the first decoction is carried out for 20-50 min with strong fire and for 2-3 h with slow fire.
5. The method for producing an anti-myocardial ischemic disease agent according to claim 1, wherein in step six, the ethanol solution has a mass concentration of 75%.
6. The method for preparing a drug for myocardial ischemic disease according to claim 1, wherein said step eight, in which houttuynia cordata is used for preparing the extract of houttuynia cordata, comprises:
(1) putting the houttuynia cordata into a grinder to be ground to obtain houttuynia cordata fragments;
(2) mixing the minced houttuynia cordata with purified water, and fully soaking until the minced houttuynia cordata absorbs water and expands; heating the mixture of the houttuynia cordata and the water, and preserving heat for 1-2 hours;
(3) and after the heat preservation is finished, cooling the mixture of the houttuynia cordata and the water to room temperature, and filtering out houttuynia cordata scraps to obtain the houttuynia cordata extract.
7. The method for preparing the anti-myocardial ischemic disease drug according to claim 1, wherein in step eight, the preparation of the dendrobium officinale extract by using dendrobium officinale comprises the following steps:
(1) drying Dendrobium officinale in the sun, placing in a temperature changing box, rapidly cooling to 0 ℃, and carrying out low-temperature stress treatment;
(2) after the low-temperature stress treatment is finished, decompressing the temperature changing box;
(3) gradually heating the temperature changing box, and stopping heating after the temperature is increased to the room temperature;
(4) extracting effective substances in the dendrobium officinale to obtain the dendrobium officinale extract.
8. The method for preparing the anti-myocardial ischemic disease drug according to claim 1, wherein in step eight, the extraction of the effective substances in the dendrobium officinale comprises the following steps:
the dendrobium officinale is crushed into 80-100-mesh particles, heated and extracted for 2-3 hours by using water with the weight 10-15 times that of the dendrobium officinale, and the dendrobium officinale extract is obtained through reduced pressure concentration.
9. The medicine for resisting myocardial ischemic diseases, which is prepared by the preparation method of the medicine for resisting myocardial ischemic diseases according to any one of claims 1 to 8, is characterized by comprising, by mass, 20 to 30 parts of salvia miltiorrhiza, 15 to 20 parts of lophatherum gracile total flavonoids, 10 to 15 parts of safflower carthamus, 8 to 12 parts of common andrographis herbs, 6 to 9 parts of angelica sinensis, 4 to 8 parts of ginkgo leaves, 5 to 7 parts of ligusticum wallichii, 2 to 3 parts of coptis chinensis, 4 to 6 parts of houttuynia cordata, 3 to 6 parts of bezoar, 1 to 3 parts of borneol and 5 to 8 parts of dendrobium officinale.
10. The agent for treating myocardial ischemic diseases according to claim 9, wherein said total flavonoids of Phyllostachys nigra leaf comprise orientin, isoorientin, swertisin, vitexin, isovitexin, luteolin and medicagine.
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Application publication date: 20210402 |