CN112587466A

CN112587466A - Method for removing striae gravidarum

Info

Publication number: CN112587466A
Application number: CN202110014820.6A
Authority: CN
Inventors: 陈琴明
Original assignee: Individual
Current assignee: Individual
Priority date: 2021-01-06
Filing date: 2021-01-06
Publication date: 2021-04-02
Anticipated expiration: 2041-01-06
Also published as: CN112587466B

Abstract

The invention relates to the technical field of striae gravidarum removal, in particular to a striae gravidarum removal method. The collagen skin cream is applied to the target tissue using a repair radiofrequency instrument. The invention provides a method for removing striae gravidarum, which can effectively remove striae gravidarum, inhibit recurrence of striae gravidarum and recover skin elasticity by a transdermal drug delivery technology; the applied collagen skin cream has good sensory experience, strong stability and wide application prospect.

Description

Method for removing striae gravidarum

Technical Field

The invention relates to the technical field of striae gravidarum removal, in particular to a striae gravidarum removal method.

Background

The striae gravidarum is mainly formed due to the influence of hormones in pregnancy, and the abdominal distension causes elastic fibers and collagen fibers of the skin to be damaged or broken, so that the abdominal skin becomes thin and thin, and pink or purple wavy patterns with different widths and lengths appear. After delivery, these lines gradually disappear, leaving white or silvery-white shiny scar lines, i.e. stretch marks. Stretch marks mainly appear on the abdominal wall, and also can appear on the inner and outer sides of thighs, buttocks, breasts, the back waist, arms and the like; the most obvious is the first lying-in woman. Once the stretch marks appear, the stretch marks are difficult to disappear, and the stretch marks are accompanied by skin looseness, breast drop and abdominal fat accumulation, so that the postpartum physical state and physical and psychological health of women are seriously influenced.

At present, the method for eliminating striae gravidarum at home and abroad mainly comprises the following steps: 1. the striae gravidarum fog gun instrument injects protein substances into the lower recess of the epidermis in a high-pressure gas mode by using an electric injection mode, so as to play a role in filling and leveling; the method is gradually consumed after about half a year of metabolism, and the sample is easy to rebound; 2. the fine grain bridging instrument adopts a needle head electrocoagulation mode, adopts high-temperature adhesion to ensure that the skin epidermis is instantly adhered and the grains are narrowed, can play a temporary effect, but the epidermis still stretches like a Chinese character after decrustation; 3. the needle roller eyebrow tattooing machine has long-term market operation, but has poor strength and depth, is difficult to achieve the effect of destroying and repairing torn fibrous tissues, and is easy to leave scars for hyperplasia; 4. micro-crystal grinding, which achieves the smoothness of the surface layer of the skin at the cost of abrasion of normal skin, but rebounds after two or three months; 5. skin grafting operation is only carried out for repairing epidermis, deep torn fibrous tissues cannot be repaired, multiple times of repair are needed, and the survival rate is low; 6. photon therapy, which can only be used in a punctiform way, needs to be used for treatment in a large area in a grading way, is not easy to control the depth and often leaves scars; 7. the skin changing method uses a chemical peeling agent, but the skin thickness and the personal reaction procedure are not fixed, so that proliferation scars are generated at times, and the skin is adversely affected by large-area use; 8. essential oil aromatherapy requires fractionated treatment, has a long treatment course, has high technical requirements on a cosmetologist, and cannot achieve the best effect.

Based on the above, the research of a method for effectively removing stretch marks becomes an urgent problem to be solved in the field.

Disclosure of Invention

The invention provides a method for removing stretch marks, overcomes the defects of long treatment course and easy rebound of the method for removing stretch marks in the prior art, and realizes the method for effectively removing stretch marks.

In a first aspect of the invention, a method of removing stretch marks is provided, wherein a collagen skin cream is applied to a target tissue using a repair radiofrequency instrument.

In a preferred embodiment, the raw materials of the collagen skin cream comprise, in weight ratio,

phase A: 1-5% of humectant, 1-5% of ethylhexyl palmitate, 2-8% of polydimethylsiloxane, 2-6.5% of stearate, 0.1-1% of vitamin derivative and 0.2% of preservative;

phase B: 5-15% of C1-4 polyhydric alcohol, 1-5% of betaine, 0.1-1% of thickening agent, 0.01-0.2% of pH regulator and the balance of water;

and C phase: acrylic polymer 0.1-1%;

phase D: polypeptide mixture 0.1-0.5%, and plant extract 2-5%;

phase E: 0.1-0.5% imidazolidinyl urea;

and (3) phase F: 0.02% of essence;

wherein the sum of the weight percentages of the phase A, the phase B, the phase C, the phase D, the phase E and the phase F is 100 percent.

In a preferred embodiment, the humectant comprises at least one of mineral oil, squalane, sorbitol, polyethylene glycol.

In a preferred embodiment, the stearate comprises at least one of PEG-100 stearate, glyceryl stearate SE, sorbitan stearate.

In a preferred embodiment, the C1-4 polyol has a surface tension of 38 to 70 dyne/cm.

In a preferred embodiment, the thickening agent comprises at least one of collagen, carbomer, sodium alginate, guar gum, starch.

In a preferred embodiment, the polypeptide mixture comprises at least one of fibronectin, glycoprotein, decapeptide-4, tripeptide-2, acetyl hexapeptide-8, pentapeptide-3.

In a preferred embodiment, the plant extract comprises at least one of a chamomile extract, a purslane extract, an aloe vera extract, a hydrangea leaf extract, a picrasma root extract, a mint leaf extract, a jojoba extract, a honeysuckle extract, and a shea butter extract.

In a preferred embodiment, the collagen skin cream is prepared by the steps of:

s1, cleaning and disinfecting the used production tools for later use;

s2, weighing the phase A raw materials according to the formula, putting the phase A raw materials into a clean oil phase pot, heating to 80-85 ℃, and uniformly stirring to obtain a phase A mixture;

s3, weighing the phase B raw materials according to the formula, putting the raw materials into a clean emulsifying pot, heating to 80-85 ℃, uniformly stirring, homogenizing, and keeping the temperature for 15-30 min;

s4, slowly pouring the mixture of the phase A into an emulsifying pot, and homogenizing for 3-5 min; adding the C-phase raw material, uniformly stirring, keeping the temperature and stirring for 10-30min, and performing vacuum defoaming to obtain a mixture II;

s5, cooling the mixture II in a water bath, adding the phase D raw material when the temperature is reduced to 42-45 ℃, and uniformly stirring; cooling to 38-42 ℃, adding the E-phase and F-phase raw materials, and uniformly stirring to obtain a mixture III;

and S6, filtering the mixture III, and discharging to obtain a finished product.

In a second aspect, the invention provides the use of a method for striae gravidarum removal, which is particularly suitable for striae gravidarum removal within 1 year after production.

Has the advantages that:

the invention provides a method for removing striae gravidarum, which has the effects of effectively removing striae gravidarum, inhibiting recurrence of striae gravidarum and recovering skin elasticity; the applied collagen skin cream has the effects of promoting the growth of skin cells, repairing damaged skin, enhancing the skin resistance and improving the skin elasticity and activity. The method is suitable for daily health skin care by transdermal administration, and has strong repairing effect on problem skin (such as ulcerated skin wound, sensitive skin, hormone-dependent dermatitis, etc.); the collagen skin cream has good sensory experience, strong stability and wide application prospect.

Detailed Description

The disclosure may be understood more readily by reference to the following detailed description of preferred embodiments of the invention and the examples included therein. Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. In case of conflict, the present specification, including definitions, will control.

The term "prepared from …" as used herein is synonymous with "comprising". The terms "comprises," "comprising," "includes," "including," "has," "having," "contains," "containing," or any other variation thereof, as used herein, are intended to cover a non-exclusive inclusion. For example, a composition, process, method, article, or apparatus that comprises a list of elements is not necessarily limited to only those elements but may include other elements not expressly listed or inherent to such composition, process, method, article, or apparatus.

The conjunction "consisting of …" excludes any unspecified elements, steps or components. If used in a claim, the phrase is intended to claim as closed, meaning that it does not contain materials other than those described, except for the conventional impurities associated therewith. When the phrase "consisting of …" appears in a clause of the subject matter of the claims rather than immediately after the subject matter, it defines only the elements described in the clause; other elements are not excluded from the claims as a whole.

When an amount, concentration, or other value or parameter is expressed as a range, preferred range, or as a range of upper preferable values and lower preferable values, this is to be understood as specifically disclosing all ranges formed from any pair of any upper range limit or preferred value and any lower range limit or preferred value, regardless of whether ranges are separately disclosed. For example, when a range of "1 to 5" is disclosed, the described range should be interpreted to include the ranges "1 to 4", "1 to 3", "1 to 2 and 4 to 5", "1 to 3 and 5", and the like. When a range of values is described herein, unless otherwise stated, the range is intended to include the endpoints thereof and all integers and fractions within the range.

The singular forms "a", "an" and "the" include plural referents unless the context clearly dictates otherwise. "optional" or "any" means that the subsequently described event or events may or may not occur, and that the description includes instances where the event occurs and instances where it does not.

Approximating language, as used herein throughout the specification and claims, is intended to modify a quantity, such that the invention is not limited to the specific quantity, but includes portions that are literally received for modification without substantial change in the basic function to which the invention is related. Accordingly, the use of "about" to modify a numerical value means that the invention is not limited to the precise value. In some instances, the approximating language may correspond to the precision of an instrument for measuring the value. In the present description and claims, range limitations may be combined and/or interchanged, including all sub-ranges contained therein if not otherwise stated.

In addition, the indefinite articles "a" and "an" preceding an element or component of the invention are not intended to limit the number requirement (i.e., the number of occurrences) of the element or component. Thus, "a" or "an" should be read to include one or at least one, and the singular form of an element or component also includes the plural unless the stated number clearly indicates that the singular form is intended.

"Polymer" means a polymeric compound prepared by polymerizing monomers of the same or different types. The generic term "polymer" embraces the terms "homopolymer", "copolymer", "terpolymer" and "interpolymer". "interpolymer" means a polymer prepared by polymerizing at least two different monomers. The generic term "interpolymer" includes the term "copolymer" (which is generally used to refer to polymers prepared from two different monomers) and the term "terpolymer" (which is generally used to refer to polymers prepared from three different monomers). It also includes polymers made by polymerizing more monomers. "blend" means a polymer formed by two or more polymers being mixed together by physical or chemical means.

In order to solve the above problems, the present invention provides, in a first aspect, a method of removing stretch marks by applying a collagen skin cream to a target tissue using a repairing radio frequency instrument.

The repair RF instruments are purchased from Guangzhou and Jiarungyi pharmaceuticals, Inc.

The repair radio frequency instrument utilizes radio frequency energy to accurately apply the collagen skin nourishing cream to target tissues with different depths on the basis of no bleeding after the skin is broken through the insulating gold probe, enables cell tissues to naturally heal through transdermal administration, stimulates the generation of growth factor cells, induces the recombination and regeneration of collagen, and achieves the effect of repairing dermal elastic fibers.

In some preferred embodiments, the raw material of the collagen skin cream comprises, in weight ratio,

and C phase: acrylic polymer 0.1-1%;

phase D: polypeptide mixture 0.1-0.5%, and plant extract 2-5%;

phase E: 0.1-0.5% imidazolidinyl urea;

and (3) phase F: 0.02% of essence;

In some preferred embodiments, the humectant comprises at least one of mineral oil, squalane, sorbitol, polyethylene glycol.

In some preferred embodiments, the stearate comprises at least one of PEG-100 stearate, glyceryl stearate SE, sorbitan stearate.

Further preferably, the stearate is PEG-100 stearate, glyceryl stearate SE and sorbitan stearate.

More preferably, the weight ratio of PEG-100 stearate, glyceryl stearate SE and sorbitan stearate is 1: (1-5): (0.5-2).

In some preferred embodiments, the C1-4 polyol has a surface tension of 38 to 70 dyne/cm.

Further preferably, the C1-4 polyhydric alcohol is propylene glycol and glycerol, and the weight ratio of the propylene glycol to the glycerol is 1: (0.8-2).

In some preferred embodiments, the thickening agent comprises at least one of collagen, carbomer, sodium alginate, guar gum, starch.

In some preferred embodiments, the polypeptide mixture includes at least one of fibronectin, glycoprotein, decapeptide-4, tripeptide-2, acetyl hexapeptide-8, pentapeptide-3.

Further preferably, the polypeptide mixture comprises fibronectin, glycoproteins, and decapeptide-4.

Still more preferably, the weight ratio of fibronectin, glycoprotein and decapeptide-4 is 1: (1-3.6): (0.5-2).

In some preferred embodiments, the plant extract comprises at least one of a chamomile extract, a purslane extract, an aloe vera extract, a hydrangea leaf extract, a picrasma root extract, a mint leaf extract, a jojoba extract, a honeysuckle extract, and a shea butter extract.

Further preferably, the plant extract is a chamomile extract, a purslane extract, an aloe vera extract, a hydrangea leaf extract, a sophora flavescens root extract, and a mint leaf extract.

More preferably, the mass ratio of the golden chamomile extract, the purslane extract, the aloe vera extract, the hydrangea leaf extract, the picrasma root extract and the mint leaf extract is (0.5-2): (1-1.6): 1: (0.5-1.5): (1-3): (0.4-0.8).

In some preferred embodiments, the collagen skin cream is prepared by the steps of:

s1, cleaning and disinfecting the used production tools for later use;

According to the invention, through a transdermal administration mode, nutrient substances are transported to damaged and broken fiber cells to achieve a repairing effect, the activity of the cells in broken lines is aroused, the cells are promoted to be continuously divided and regenerated, the circulation metabolism function is accelerated, skin collagen is regenerated, dermal reticular fibers are remodeled, and the effects of fundamentally repairing and relapse of striae gravidarum from source tissues are achieved.

On the other hand, the invention efficiently combines the transdermal drug delivery technology with the efficient skin repairing effect of the collagen skin nourishing cream, and can (1) promote the growth of skin cells and repair damaged skin; (2) enhancing skin resistance, improving skin quality, and regulating skin sensitivity, irritation, allergy, redness, and pruritus; (3) improving skin cell activity, promoting cell metabolism, accelerating metabolism of surface layer color spots, improving skin color, and making skin bright and glossy; (4) promoting skin cells to secrete collagen, improving skin elasticity, smoothing and tightening skin, and fading cell stem wrinkles; (5) promoting skin cells to secrete active substances, improving the water-locking capacity of the skin, and enabling the skin to be tender and moist. The method starts from cells, actively repairs, activates and regenerates skin cells, really solves problem skin defects, integrates a biological transdermal technology, has the advantages of strong activity, high absorption rate and quick response, is safe and reliable in action process, and is not easy to generate adverse reactions and side effects.

The invention also discovers that the collagen skin nourishing cream is rich in various polypeptide active substances, and not only can be used for nourishing healthy skin, but also can be used for repairing and treating problem skin. The transdermal drug delivery method greatly improves the transportation efficiency of the nutrient components, provides convenience from the aspect of transportation approaches, and enhances the effect of improving various problems of skin. For example, the skin surface ulcer caused by steam scald is used for 2-3 times every day, so that the injured skin can be obviously repaired within one week, and the skin is basically healed after two weeks; after one month, the wound is recovered as before, and the whole process can achieve the effect of scar-free repair without using other medicines; for example, for a sensitive skin patient, the sensitive skin patient is in a sensitive period before treatment, the skin is red and swollen, itchy, dark yellow and lusterless, after the collagen skin cream is continuously used for 6 months, the facial allergic symptoms disappear, the skin is moistened and glossy, the skin color is obviously brightened, and the allergic recurrence phenomenon does not appear for a plurality of subsequent months; for example, for a patient with hormone-dependent dermatitis, symptoms of flushing, dryness, pain, desquamation and facial follicular inflammatory pustule before treatment are kept for 6-12 months, the symptoms of facial dermatitis are obviously relieved, symptoms of flushing and dermatitis are relieved, the skin is tender and soft, and no recurrence tendency exists.

In particular to 1, the collagen skin-nourishing cream prepared by the invention belongs to DES brand under-the-flag products.

In particular to 2, the method for removing stretch marks provided by the invention belongs to DES brand development technology.

Examples

In order to better understand the above technical solutions, the following detailed descriptions will be provided with reference to specific embodiments. It should be noted that the following examples are only for illustrating the present invention and should not be construed as limiting the scope of the present invention, and that the insubstantial modifications and adaptations of the present invention by those skilled in the art based on the above disclosure are still within the scope of the present invention. In addition, the raw materials are commercially available and the extraction methods of the extract are all conventional extraction methods, if not otherwise specified.

Example 1.

This example provides a method of removing stretch marks using a prosthetic radio frequency instrument to apply a collagen skin cream to a target tissue.

The raw materials of the collagen skin-nourishing cream comprise, by weight ratio,

phase A: humectant 2%, ethylhexyl palmitate 3%, cyclopentadimethylsiloxane 5%, stearate 4.5%, tocopherol acetate 0.5%, preservative 0.2%;

phase B: 10% of C1-4 polyhydric alcohol, 4% of betaine, 0.8% of thickening agent, 0.12% of pH regulator and the balance of water;

and C phase: acrylic polymer 0.5%;

phase D: 0.5% of polypeptide mixture and 3% of plant extract;

phase E: 0.3% of bis (hydroxymethyl) imidazolidinyl urea;

and (3) phase F: 0.02% of essence;

The humectant is mineral oil, purchased from wang chemical company, guang zhou hua.

The stearic acid ester is PEG-100 stearic acid ester, glyceryl stearate SE and sorbitan stearate, the weight ratio of the PEG-100 stearic acid ester to the glyceryl stearate SE to the sorbitan stearate is 1: 2.5: 1.

the preservative is hydroxymethyl and hydroxypropyl, and the weight ratio of the hydroxymethyl to the hydroxypropyl is 1: 1.

the C1-4 polyhydric alcohol is propylene glycol and glycerol, and the weight ratio of the propylene glycol to the glycerol is 1: 1.

the thickening agent is collagen and carbomer, and the weight ratio of the collagen to the carbomer is 5: 1.

the pH regulator is triethanolamine and has a CAS number of 102-71-6.

The acrylic polymer comprises tween 60 and sodium polyacrylate, and the weight ratio of tween 60 to sodium polyacrylate is 3: 2.

the polypeptide mixture is fibronectin, glycoprotein and decapeptide-4; fibronectin, glycoprotein and decapeptide-4 in a weight ratio of 1: 2: 1.2. fibronectin was purchased from Shanghai diligent kang Biotech, Inc., glycoprotein was purchased from Wuhan Eimei technologies, Inc., decapeptide-4 was purchased from Doudu Yunshi chemical, Inc.

The plant extracts are golden chamomile extracts, purslane extracts, aloe barbadensis extracts, hydrangea leaf extracts, sophora flavescens root extracts and mint leaf extracts; the weight ratio of the golden chamomile extract to the purslane extract to the aloe barbadensis extract to the hydrangea leaf extract to the sophora flavescens root extract to the mint leaf extract is 1: 1.2: 1: 1: 2: 0.6.

the golden yellow chamomile extract is purchased from Sichuan province biotechnology limited, belongs to Compositae, and is called Comositae by Latin name; the herba Portulacae extract is purchased from Sirana Baichuan Biotechnology Co., Ltd, belongs to Portulacaceae, and has a name of Portulacaceae; the aloe vera extract is purchased from Shaanxi Hulngda Biotech limited company, belongs to Liliaceae, and is called Liliaceae by Latin name; the folium hydrangeae extract is purchased from Chenguang Biotechnology group, Inc., belonging to Saxifragaceae, and Latin is Saxfragaceae; the extract of the root of Sophora alopecuroides is purchased from Siennan bioscience, Inc., belonging to Leguminosae, and has the name of Leguminosae; peppermint leaf extract was purchased from Shaanxi Senyue Biotech, Inc., belonging to Labiatae under the name Labiatae.

The essence is purchased from Guangzhou Fei Asia Li Ge Biotech Co., Ltd, and has the model of XG-11174.

The preparation method of the collagen skin nourishing cream comprises the following steps:

s1, cleaning and disinfecting the used production tools for later use;

s2, weighing the phase A raw materials according to the formula, putting the phase A raw materials into a clean oil phase pot, heating to 82 ℃, and uniformly stirring to obtain a phase A mixture;

s3, weighing the phase B raw materials according to the formula, putting the raw materials into a clean emulsifying pot, heating to 82 ℃, uniformly stirring, homogenizing, and keeping the temperature for 24 min;

s4, slowly pouring the phase A mixture into an emulsifying pot, and homogenizing for 4 min; adding the C-phase raw material, uniformly stirring, keeping the temperature and stirring for 20min, and performing vacuum defoaming to obtain a mixture II;

s5, cooling the mixture II in a water bath, adding the D-phase raw material when the temperature is reduced to 43 ℃, and uniformly stirring; cooling to 40 ℃, adding the raw materials of the E phase and the F phase, and uniformly stirring to obtain a mixture III;

s6, filtering the mixture III by using 200-mesh double-layer filter cloth, and discharging to obtain a finished product.

Example 2.

and C phase: acrylic polymer 0.5%;

phase D: 0.5% of polypeptide mixture and 3% of plant extract;

phase E: 0.3% of bis (hydroxymethyl) imidazolidinyl urea;

and (3) phase F: 0.02% of essence;

The humectant is squalane, and the CAS number is 111-01-3.

the pH regulator is triethanolamine and has a CAS number of 102-71-6.

The acrylic polymer is Tween 80 and sodium polyacrylate, and the weight ratio of the Tween 60 to the sodium polyacrylate is 3: 2.

The plant extracts are shea butter extracts, purslane extracts, aloe barbadensis extracts, hydrangea leaf extracts, sophora flavescens root extracts and mint leaf extracts; the mass ratio of the shea butter extract, the purslane extract, the aloe barbadensis extract, the hydrangea leaf extract, the sophora flavescens root extract and the mint leaf extract is 1: 1.2: 1: 1: 2: 0.6.

the shea butter extract is purchased from Sansheng biological development Limited company, Baoji City, and belongs to Sapotaceae, and latin is Vitellaria paradoxa C.F. Gaertn; the herba Portulacae extract is purchased from Sirana Baichuan Biotechnology Co., Ltd, belongs to Portulacaceae, and has a name of Portulacaceae; the aloe vera extract is purchased from Shaanxi Hulngda Biotech limited company, belongs to Liliaceae, and is called Liliaceae by Latin name; the folium hydrangeae extract is purchased from Chenguang Biotechnology group, Inc., belonging to Saxifragaceae, and Latin is Saxfragaceae; the extract of the root of Sophora alopecuroides is purchased from Siennan bioscience, Inc., belonging to Leguminosae, and has the name of Leguminosae; peppermint leaf extract was purchased from Shaanxi Senyue Biotech, Inc., belonging to Labiatae under the name Labiatae.

s1, cleaning and disinfecting the used production tools for later use;

Example 3.

phase A: 5% of humectant, 2% of ethylhexyl palmitate, 4% of cyclopentadimethylsiloxane, 5% of stearate, 0.5% of tocopherol acetate and 0.2% of preservative;

phase B: 7% of C1-4 polyhydric alcohol, 3% of betaine, 0.8% of thickening agent, 0.12% of pH regulator and the balance of water;

and C phase: acrylic polymer 0.5%;

phase D: 0.5% of polypeptide mixture and 3% of plant extract;

phase E: 0.3% of bis (hydroxymethyl) imidazolidinyl urea;

and (3) phase F: 0.02% of essence;

the pH regulator is triethanolamine and has a CAS number of 102-71-6.

s1, cleaning and disinfecting the used production tools for later use;

Example 4.

phase A: humectant 3%, ethylhexyl palmitate 1%, cyclopentadimethylsiloxane 6%, stearate 3%, tocopherol acetate 0.5%, preservative 0.2%;

phase B: 12% of C1-4 polyhydric alcohol, 4% of betaine, 0.8% of thickening agent, 0.12% of pH regulator and the balance of water;

and C phase: acrylic polymer 0.5%;

phase D: 0.5% of polypeptide mixture and 3% of plant extract;

phase E: 0.3% of bis (hydroxymethyl) imidazolidinyl urea;

and (3) phase F: 0.02% of essence;

the pH regulator is triethanolamine and has a CAS number of 102-71-6.

s1, cleaning and disinfecting the used production tools for later use;

Example 5.

and C phase: acrylic polymer 0.5%;

phase D: 0.5% of polypeptide mixture and 3% of plant extract;

phase E: 0.3% of bis (hydroxymethyl) imidazolidinyl urea;

and (3) phase F: 0.02% of essence;

the pH regulator is triethanolamine and has a CAS number of 102-71-6.

s1, cleaning and disinfecting the used production tools for later use;

s2, weighing the phase A raw materials according to the formula, putting the phase A raw materials into a clean oil phase pot, heating to 80 ℃, and uniformly stirring to obtain a phase A mixture;

s3, weighing the phase B raw materials according to the formula, putting the raw materials into a clean emulsifying pot, heating to 80 ℃, uniformly stirring, homogenizing, and keeping the temperature for 24 min;

s4, slowly pouring the phase A mixture into an emulsifying pot, and homogenizing for 3 min; adding the C-phase raw material, uniformly stirring, keeping the temperature and stirring for 20min, and performing vacuum defoaming to obtain a mixture II;

s5, cooling the mixture II in a water bath, adding the D-phase raw material when the temperature is reduced to 42 ℃, and uniformly stirring; cooling to 39 ℃, adding the raw materials of the E phase and the F phase, and uniformly stirring to obtain a mixture III;

Example 6.

The specific implementation mode of the method for removing stretch marks is the same as that of example 1. Except that no plant extract was added.

Example 7.

The specific implementation mode of the method for removing stretch marks is the same as that of example 1. Except that no polypeptide mixture was added.

Example 8.

The specific implementation mode of the method for removing stretch marks is the same as that of example 1. The different points are that the mass ratio of the golden chamomile extract to the purslane extract to the aloe barbadensis extract to the hydrangea leaf extract to the sophora flavescens root extract to the mint leaf extract is 2: 1: 2: 2: 1: 2.

example 9.

The specific implementation mode of the method for removing stretch marks is the same as that of example 1. Except that the C1-4 polyol is 1, 3-butanediol.

Example 10.

The specific implementation mode of the method for removing stretch marks is the same as that of example 1. The different points are that the preparation steps of the collagen skin cream comprise:

s1, cleaning and disinfecting the used production tools for later use;

s2, weighing the phase A raw materials according to the formula, putting the phase A raw materials into a clean oil phase pot, heating to 70 ℃, and uniformly stirring to obtain a phase A mixture;

s3, weighing the phase B raw materials according to the formula, putting the raw materials into a clean emulsifying pot, heating to 70 ℃, uniformly stirring, homogenizing, and keeping the temperature for 24 min;

s5, cooling the mixture II in a water bath, adding the D-phase raw material when the temperature is reduced to 43 ℃, and uniformly stirring;

cooling to 40 deg.C, adding the raw materials of phase E and phase F, and stirring to obtain the final product.

Performance test method

Striae gravidarum removing effect:

50 postnatal volunteers were randomly selected and divided into 5 groups (10 per group) and striae gravidarum removal treatment was performed according to the method of examples 1-5. The subjects were administered according to the same method and dosage, 1 time per day for 3 months. Subjects were within 1 year of birth and each had severe striae of pregnancy. After 3 months, the striae gravidarum is obviously faded in all the subjects, the tracking observation is continued for 6 months, and the subjects have no striae gravidarum rebound.

Sensory evaluation:

20 volunteers were randomly recruited, smeared with the same amount of the collagen skin cream prepared in examples 1 to 10, scored for the degree of easy-open, feeling of use experience of the collagen skin cream, scored from 1 (poor) to 10 (excellent), and the average of the scoring results was calculated to evaluate the sensory experience of application of the example samples.

High-temperature stability:

the collagen skin cream prepared in the examples 1 to 10 was stored at 45 ℃ for 72 hours, and then taken out to observe the layering and discoloration of the collagen skin cream.

Performance test data

TABLE 1 results of the Performance test of examples 1 to 10

Finally, it is pointed out that the foregoing examples are illustrative only, serving to explain some of the characteristics of the process according to the invention. The appended claims are intended to claim as broad a scope as is contemplated, and the examples presented herein are merely illustrative of selected implementations in accordance with all possible combinations of examples. Accordingly, it is applicants' intention that the appended claims are not to be limited by the choice of examples illustrating features of the invention. Also, where numerical ranges are used in the claims, subranges therein are included, and variations in these ranges are also to be construed as possible being covered by the appended claims.

Claims

1. A method of removing stretch marks, wherein a collagen skin cream is applied to a target tissue using a repair radiofrequency instrument.

2. The method for removing stretch marks according to claim 1, wherein the raw materials of the collagen skin cream comprise, in weight proportion,

and C phase: acrylic polymer 0.1-1%;

phase D: polypeptide mixture 0.1-0.5%, and plant extract 2-5%;

phase E: 0.1-0.5% imidazolidinyl urea;

and (3) phase F: 0.02% of essence;

3. The method for removing stretch marks according to claim 2, wherein the humectant comprises at least one of mineral oil, squalane, sorbitol, and polyethylene glycol.

4. The method for removing stretch marks according to claim 2, wherein the stearate comprises at least one of PEG-100 stearate, glyceryl stearate SE, sorbitan stearate.

5. The method for removing stretch marks of claim 2, wherein the C1-4 polyol has a surface tension of 38-70 dyne/cm.

6. The method of claim 2, wherein the thickening agent comprises at least one of collagen, carbomer, sodium alginate, guar gum, and starch.

7. The method of claim 2, wherein the polypeptide mixture comprises at least one of fibronectin, glycoprotein, decapeptide-4, tripeptide-2, acetyl hexapeptide-8, pentapeptide-3.

8. The method of claim 2, wherein the plant extract comprises at least one of a chamomile extract, a purslane extract, an aloe vera extract, a hydrangea leaf extract, a sophora flavescens root extract, a mint leaf extract, a jojoba extract, a honeysuckle extract, and a shea butter extract.

9. The method for removing stretch marks according to claim 2, wherein the collagen skin cream is prepared by the steps of:

s1, cleaning and disinfecting the used production tools for later use;

s5, cooling the mixture II in a water bath, adding the phase D raw material when the temperature is reduced to 42-45 ℃, and uniformly stirring;

cooling to 38-42 ℃, adding the E-phase and F-phase raw materials, and uniformly stirring to obtain a mixture III;

10. Use of a method according to any one of claims 1 to 9 for striae gravidarum removal within 1 year of production.