CN112584877A - 用于无血管环境和角膜植入物的上皮化微孔生物材料 - Google Patents

用于无血管环境和角膜植入物的上皮化微孔生物材料 Download PDF

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Publication number
CN112584877A
CN112584877A CN201980052732.6A CN201980052732A CN112584877A CN 112584877 A CN112584877 A CN 112584877A CN 201980052732 A CN201980052732 A CN 201980052732A CN 112584877 A CN112584877 A CN 112584877A
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CN
China
Prior art keywords
microporous
eptfe
biocomposite
membrane
fibrils
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201980052732.6A
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English (en)
Chinese (zh)
Inventor
G·V·巴拉吉
P·J·菲希尔
T·B·舒米德尔
A·辛格
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
WL Gore and Associates Inc
Original Assignee
WL Gore and Associates Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by WL Gore and Associates Inc filed Critical WL Gore and Associates Inc
Publication of CN112584877A publication Critical patent/CN112584877A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/56—Porous materials, e.g. foams or sponges
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/0077—Special surfaces of prostheses, e.g. for improving ingrowth
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/14—Eye parts, e.g. lenses or corneal implants; Artificial eyes
    • A61F2/142—Cornea, e.g. artificial corneae, keratoprostheses or corneal implants for repair of defective corneal tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/16—Macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/28—Materials for coating prostheses
    • A61L27/34—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L27/44—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/0077—Special surfaces of prostheses, e.g. for improving ingrowth
    • A61F2002/0081—Special surfaces of prostheses, e.g. for improving ingrowth directly machined on the prosthetic surface, e.g. holes, grooves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/0077—Special surfaces of prostheses, e.g. for improving ingrowth
    • A61F2002/0086—Special surfaces of prostheses, e.g. for improving ingrowth for preferentially controlling or promoting the growth of specific types of cells or tissues
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/18—Modification of implant surfaces in order to improve biocompatibility, cell growth, fixation of biomolecules, e.g. plasma treatment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/16—Materials or treatment for tissue regeneration for reconstruction of eye parts, e.g. intraocular lens, cornea

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Transplantation (AREA)
  • Veterinary Medicine (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Dispersion Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Composite Materials (AREA)
  • Materials Engineering (AREA)
  • Ophthalmology & Optometry (AREA)
  • Prostheses (AREA)
  • Materials For Medical Uses (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
CN201980052732.6A 2018-06-14 2019-06-14 用于无血管环境和角膜植入物的上皮化微孔生物材料 Pending CN112584877A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862684843P 2018-06-14 2018-06-14
US62/684,843 2018-06-14
PCT/US2019/037301 WO2019241700A1 (en) 2018-06-14 2019-06-14 Epitheliazing microporous biomaterial for use in avascular environments and in corneal implants

Publications (1)

Publication Number Publication Date
CN112584877A true CN112584877A (zh) 2021-03-30

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Family Applications (1)

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CN201980052732.6A Pending CN112584877A (zh) 2018-06-14 2019-06-14 用于无血管环境和角膜植入物的上皮化微孔生物材料

Country Status (8)

Country Link
US (2) US12257368B2 (https=)
EP (1) EP3806916A1 (https=)
JP (2) JP2021526921A (https=)
KR (1) KR20210019526A (https=)
CN (1) CN112584877A (https=)
AU (3) AU2019287735A1 (https=)
CA (2) CA3103272C (https=)
WO (1) WO2019241700A1 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11280504B2 (en) * 2020-05-20 2022-03-22 James T. Crawford, III Low air leakage, secure clean room with reduced contamination and secure chemical resistance
US12220656B1 (en) 2024-03-25 2025-02-11 ThreeSquared Solutions L.L.C. Removable inner frame assembly for clean environments

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1939957A (zh) * 2005-09-30 2007-04-04 通用电气公司 亲水膜及其相关方法
US20080255663A1 (en) * 2007-04-13 2008-10-16 Akpek Esen K Artificial Cornea and Method of Making Same

Family Cites Families (61)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA962021A (en) 1970-05-21 1975-02-04 Robert W. Gore Porous products and process therefor
US4693715A (en) 1986-06-19 1987-09-15 Abel Robert Jr Artificial cornea
US5100689A (en) 1987-04-10 1992-03-31 University Of Florida Surface modified surgical instruments, devices, implants, contact lenses and the like
US4865601A (en) 1987-07-07 1989-09-12 Caldwell Delmar R Intraocular prostheses
US5282851A (en) 1987-07-07 1994-02-01 Jacob Labarre Jean Intraocular prostheses
US5108428A (en) 1988-03-02 1992-04-28 Minnesota Mining And Manufacturing Company Corneal implants and manufacture and use thereof
US5183545A (en) 1989-04-28 1993-02-02 Branca Phillip A Electrolytic cell with composite, porous diaphragm
GB8915974D0 (en) 1989-07-12 1989-08-31 Gore W L & Ass Uk Hydrophilic semi-permeable ptfe membranes and their manufacture
FR2649605B1 (fr) 1989-07-13 1995-07-21 France Chirurgie Instr Implant corneen
US5462781A (en) 1991-06-14 1995-10-31 W. L. Gore & Associates, Inc. Surface modified porous expanded polytetrafluoroethylene and process for making
AU650156B2 (en) 1992-08-05 1994-06-09 Lions Eye Institute Limited Keratoprosthesis and method of producing the same
US5321109A (en) 1992-11-17 1994-06-14 Impra, Inc. Uniformly expanded PTFE film
US5300115A (en) 1992-11-19 1994-04-05 Keratos, Inc. Intraocular prosthesis
DE69428056T2 (de) 1994-09-02 2002-01-03 W.L. Gore & Associates, Inc. Poröse polytetrafluorethylen zusammensetzungen
US5476589A (en) 1995-03-10 1995-12-19 W. L. Gore & Associates, Inc. Porpous PTFE film and a manufacturing method therefor
WO1997010807A1 (en) 1995-09-22 1997-03-27 Gore Hybrid Technologies, Inc. Improved cell encapsulation device
FR2744013B1 (fr) 1996-01-30 1998-04-24 Corneal Ind Dispositif de keratoprothese
ID21031A (id) 1996-11-13 1999-04-08 Menicon Co Ltd Kornea buatan
US6818018B1 (en) 1998-08-14 2004-11-16 Incept Llc In situ polymerizable hydrogels
US6102946A (en) 1998-12-23 2000-08-15 Anamed, Inc. Corneal implant and method of manufacture
US7049380B1 (en) 1999-01-19 2006-05-23 Gore Enterprise Holdings, Inc. Thermoplastic copolymer of tetrafluoroethylene and perfluoromethyl vinyl ether and medical devices employing the copolymer
JP2000325369A (ja) 1999-05-17 2000-11-28 Menicon Co Ltd 人工角膜
US6689165B2 (en) 2000-03-31 2004-02-10 Board Of Supervisors Of Louisana State University And Agricultural And Mechanical College Surface modifications for enhanced epithelialization
US6541589B1 (en) 2001-10-15 2003-04-01 Gore Enterprise Holdings, Inc. Tetrafluoroethylene copolymer
JP4489437B2 (ja) 2002-02-21 2010-06-23 エンセル，インコーポレイテッド 表面コーティングとしての固定化生物活性ヒドロゲルマトリックス
US20030225439A1 (en) 2002-05-31 2003-12-04 Cook Alonzo D. Implantable product with improved aqueous interface characteristics and method for making and using same
CN1662192A (zh) 2002-06-18 2005-08-31 利兰·斯坦福初级大学董事会 人造角膜
US20040024448A1 (en) 2002-08-05 2004-02-05 Chang James W. Thermoplastic fluoropolymer-coated medical devices
WO2004028410A1 (en) 2002-09-24 2004-04-08 Lions Eye Institute Limited Biointegrable keratoprosthesis
US20040173978A1 (en) 2003-03-06 2004-09-09 Christopher Bowen PTFE membranes and gaskets made therefrom
EP1790316A4 (de) 2004-06-17 2012-05-16 Zakrytoe Akcionernoe Obschestvo N Proizv Complex Ecoflon Implantat zur verstärkung der hornhaut und keratoprothese mit einer platte aus porösem polytetrafluorethylen
US20060025852A1 (en) 2004-08-02 2006-02-02 Armstrong Joseph R Bioabsorbable self-expanding endolumenal devices
US20060047311A1 (en) 2004-08-26 2006-03-02 Lutz David I Expanded PTFE articles and method of making same
US7531611B2 (en) 2005-07-05 2009-05-12 Gore Enterprise Holdings, Inc. Copolymers of tetrafluoroethylene
US7306729B2 (en) 2005-07-18 2007-12-11 Gore Enterprise Holdings, Inc. Porous PTFE materials and articles produced therefrom
US20070168025A1 (en) 2006-01-13 2007-07-19 Sohrab Darougar Artificial cornea
US20080150177A1 (en) 2006-12-20 2008-06-26 Bausch & Lomb Incorporated Surface treatment of fluorinated ophthalmic devices
WO2009012406A1 (en) 2007-07-17 2009-01-22 Transcend Medical, Inc. Ocular implant with hydrogel expansion capabilities reference to priority document
JP5484663B2 (ja) 2007-09-25 2014-05-07 三洋電機株式会社 太陽電池モジュールの製造方法
US8637144B2 (en) 2007-10-04 2014-01-28 W. L. Gore & Associates, Inc. Expandable TFE copolymers, method of making, and porous, expended articles thereof
KR20100136453A (ko) 2008-02-18 2010-12-28 큐엘티 플러그 딜리버리, 인코포레이티드 누관 임플란트 및 이와 관련된 방법
US9943401B2 (en) 2008-04-04 2018-04-17 Eugene de Juan, Jr. Therapeutic device for pain management and vision
WO2009135068A1 (en) 2008-04-30 2009-11-05 University Of Washington Artificial cornea
US20100081293A1 (en) 2008-10-01 2010-04-01 Applied Materials, Inc. Methods for forming silicon nitride based film or silicon carbon based film
DK2373321T3 (en) 2008-12-05 2016-06-13 Biomed Device S R L Biovedhæftende platelet lysate and compositions thereof for the treatment of mucostitis
US9139669B2 (en) 2009-03-24 2015-09-22 W. L. Gore & Associates, Inc. Expandable functional TFE copolymer fine powder, the expandable functional products obtained therefrom and reaction of the expanded products
ES2704162T3 (es) 2010-09-30 2019-03-14 Keramed Inc Córnea artificial deformable reversible
GB201017637D0 (en) 2010-10-20 2010-12-01 Univ Dundee Device for monitoring intraocular pressure
CN102283720A (zh) 2011-08-01 2011-12-21 姚晓明 一种人工角膜
JP5989780B2 (ja) 2011-09-14 2016-09-07 フォーサイト・ビジョン５・インコーポレイテッドＦｏｒｓｉｇｈｔ Ｖｉｓｉｏｎ５，Ｉｎｃ． 眼挿入装置および方法
US9974646B2 (en) 2012-09-05 2018-05-22 University Of Miami Keratoprosthesis, and system and method of corneal repair using same
RU2652063C2 (ru) 2012-10-26 2018-04-24 Форсайт Вижн5, Инк. Офтальмологическая система для замедленного высвобождения лекарственного средства в глазу
EP3263637B1 (en) 2013-01-30 2020-08-12 W. L. Gore & Associates, Inc. Method for producing porous articles from ultra high molecular weight polyethylene
EP2839949B1 (en) 2013-08-23 2016-10-12 W.L. Gore & Associates GmbH Process for the production of a structured film
MX358957B (es) 2013-10-03 2018-09-10 Inst Politecnico Nacional Composición farmacéutica de un lisado plaquetario con actividad de regeneración celular.
US9932429B2 (en) 2014-07-29 2018-04-03 W. L. Gore & Associates, Inc. Method for producing porous articles from alternating poly(ethylene tetrafluoroethylene) and articles produced therefrom
US9441088B2 (en) 2014-07-29 2016-09-13 W. L. Gore & Associates, Inc. Articles produced from VDF-co-(TFE or TrFE) polymers
US12280525B2 (en) 2014-07-29 2025-04-22 W. L. Gore & Associates, Inc. Porous articles formed from polyparaxylylene and processes for forming the same
US10987638B2 (en) 2015-06-19 2021-04-27 W. L. Gore & Associates, Inc. Asymmetric polytetrafluoroethylene composite having a macro-textured surface and method for making the same
EP3287149A1 (en) 2016-08-22 2018-02-28 Friedrich-Alexander-Universität Erlangen-Nürnberg Wound dressing comprising polymer fibers
WO2019241699A1 (en) 2018-06-14 2019-12-19 W. L. Gore & Associates, Inc. Artificial cornea

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1939957A (zh) * 2005-09-30 2007-04-04 通用电气公司 亲水膜及其相关方法
US20080255663A1 (en) * 2007-04-13 2008-10-16 Akpek Esen K Artificial Cornea and Method of Making Same

Also Published As

Publication number Publication date
JP2023133306A (ja) 2023-09-22
US20250195726A1 (en) 2025-06-19
AU2022224781B2 (en) 2024-02-22
AU2022224781A1 (en) 2022-09-22
KR20210019526A (ko) 2021-02-22
US20210252194A1 (en) 2021-08-19
AU2024203344A1 (en) 2024-06-06
EP3806916A1 (en) 2021-04-21
CA3206692A1 (en) 2019-12-19
CA3103272A1 (en) 2019-12-19
AU2022224781C1 (en) 2024-07-11
US12257368B2 (en) 2025-03-25
JP2021526921A (ja) 2021-10-11
AU2019287735A1 (en) 2021-01-28
WO2019241700A1 (en) 2019-12-19
CA3103272C (en) 2023-09-19

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