CN112584874A - 用于治疗莱伯氏遗传性视神经病变的组合物和方法 - Google Patents

用于治疗莱伯氏遗传性视神经病变的组合物和方法 Download PDF

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CN112584874A
CN112584874A CN201980054770.5A CN201980054770A CN112584874A CN 112584874 A CN112584874 A CN 112584874A CN 201980054770 A CN201980054770 A CN 201980054770A CN 112584874 A CN112584874 A CN 112584874A
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nucleic acid
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李斌
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Wuhan Niufusi Biological Technology Co ltd
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Wuhan Niufusi Biological Technology Co ltd
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Priority claimed from CN201810948193.1A external-priority patent/CN110846392A/zh
Priority claimed from PCT/CN2018/103937 external-priority patent/WO2020000641A1/zh
Priority claimed from CN201811221305.XA external-priority patent/CN111073899B/zh
Priority claimed from CN201811230856.2A external-priority patent/CN111068071A/zh
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CN201980054770.5A 2018-08-20 2019-08-20 用于治疗莱伯氏遗传性视神经病变的组合物和方法 Pending CN112584874A (zh)

Applications Claiming Priority (15)

Application Number Priority Date Filing Date Title
CN201810948193.1A CN110846392A (zh) 2018-08-20 2018-08-20 一种重组腺相关病毒或含其的试剂盒及其应用
CN2018109481931 2018-08-20
CNPCT/CN2018/103937 2018-09-04
PCT/CN2018/103937 WO2020000641A1 (zh) 2018-06-29 2018-09-04 编码人nadh脱氢酶亚单位蛋白的核酸及其应用
CN201811221305.XA CN111073899B (zh) 2018-10-19 2018-10-19 一种编码人nadh脱氢酶亚单位4蛋白的核酸及其应用
CN201811221305X 2018-10-19
CN2018112308562 2018-10-22
CN201811230856.2A CN111068071A (zh) 2018-10-22 2018-10-22 基因治疗Leber遗传学视神经病变
PCT/CN2018/113799 WO2020082417A1 (zh) 2018-10-22 2018-11-02 基因治疗Leber遗传性视神经病变
CNPCT/CN2018/113799 2018-11-02
PCT/CN2018/118662 WO2020077756A1 (zh) 2018-10-19 2018-11-30 Nd4蛋白的编码序列及其应用
CNPCT/CN2018/118662 2018-11-30
CNPCT/CN2019/070461 2019-01-04
PCT/CN2019/070461 WO2020037938A1 (zh) 2018-08-20 2019-01-04 一种重组腺相关病毒或含其的试剂盒及其应用
PCT/CN2019/101538 WO2020038352A1 (en) 2018-08-20 2019-08-20 Compositions and methods for treating leber's hereditary optic neuropathy

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CN112584874A true CN112584874A (zh) 2021-03-30

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CN201980054770.5A Pending CN112584874A (zh) 2018-08-20 2019-08-20 用于治疗莱伯氏遗传性视神经病变的组合物和方法

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US (2) US11352645B2 (OSRAM)
EP (1) EP3840785A4 (OSRAM)
JP (2) JP7403852B2 (OSRAM)
KR (1) KR20210068014A (OSRAM)
CN (1) CN112584874A (OSRAM)
AU (1) AU2019323434A1 (OSRAM)
CA (1) CA3109432A1 (OSRAM)
SG (1) SG11202101032VA (OSRAM)
WO (1) WO2020038352A1 (OSRAM)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114929872A (zh) * 2019-12-09 2022-08-19 武汉纽福斯生物科技有限公司 用nadh脱氢酶蛋白治疗莱伯遗传性视神经病变的组合物和方法
WO2023011632A1 (zh) * 2021-08-06 2023-02-09 武汉纽福斯生物科技有限公司 用于治疗由于nd4突变造成的莱伯氏遗传性视神经病变的组合物和方法
CN116789772A (zh) * 2022-03-18 2023-09-22 北京安龙生物医药有限公司 Aav5扩容衣壳突变体及其扩容检测方法
CN118320132A (zh) * 2024-04-26 2024-07-12 首都医科大学附属北京友谊医院 重组腺相关病毒rAAV2/Rec2作为胰腺靶向性载体的应用

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Publication number Priority date Publication date Assignee Title
CN113528510A (zh) 2018-06-29 2021-10-22 武汉纽福斯生物科技有限公司 治疗遗传性视神经病变的组合物和方法
CA3109432A1 (en) 2018-08-20 2020-02-27 Wuhan Neurophth Biotechnology Limited Company Compositions and methods for treating leber's hereditary optic neuropathy
US20210100856A1 (en) * 2019-09-11 2021-04-08 Adverum Biotechnologies, Inc. Methods of treating ocular neovascular diseases using aav2 variants encoding aflibercept
WO2024144330A1 (ko) * 2022-12-29 2024-07-04 주식회사 엣진 레베르 유전성 시신경병증의 미토콘드리아 염기 변이 교정 시스템

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CN102634527A (zh) * 2012-04-11 2012-08-15 华中科技大学同济医学院附属同济医院 重组人nadh脱氢酶亚单位4基因及其表达载体构建方法
CN104450747A (zh) * 2014-09-23 2015-03-25 李斌 用于治疗Leber遗传性视神经病变的重组腺相关病毒-NADH脱氢酶亚单位4基因全长以及药剂
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