CN112547144A - Capillary tube for storing and adding sample stabilizer - Google Patents

Capillary tube for storing and adding sample stabilizer Download PDF

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Publication number
CN112547144A
CN112547144A CN202011267007.1A CN202011267007A CN112547144A CN 112547144 A CN112547144 A CN 112547144A CN 202011267007 A CN202011267007 A CN 202011267007A CN 112547144 A CN112547144 A CN 112547144A
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capillary
head
thick
thin end
thin
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CN202011267007.1A
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CN112547144B (en
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徐文
马霖
孙加琳
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Affiliated Hospital of University of Qingdao
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Affiliated Hospital of University of Qingdao
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    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

The invention discloses a capillary tube for storing and adding a sample stabilizer, which comprises a thin end sealing head, a thick end sealing head, a capillary tube, a sample stabilizer, a thin end nick, a thin end head, a thick end head and a thick end nick. The thin end sealing head and the thick end sealing head can prevent organic solvent from volatilizing, water solution bacteria are placed to breed, the capillary tube can be placed for a long time, storage time can be prolonged, the capillary tube thin end is arranged in an arc shape, the diameter of the capillary tube thin end is 0.3-2mm, and broken capillaries are convenient to puncture a rubber pad of an external blood sampling tube cap due to the thin wall and the sharp characteristic, so that the blood sampling cap does not need to be opened, operators can be prevented from being infected by pathogenic microorganisms inside the blood sampling tube.

Description

Capillary tube for storing and adding sample stabilizer
Technical Field
The invention relates to a capillary tube for storing and adding a sample stabilizer, in particular to the technical field of medicine.
Background
The blood concentration detection is guided by the pharmacokinetic principle, and the concentration of the medicine in blood is analyzed and measured to evaluate the curative effect or determine the administration scheme, so that the administration scheme is individualized, the treatment level of the medicine is improved, and the clinical safe, effective and reasonable administration is achieved. Although blood is not a major metabolic organ of the human body, a small amount of enzymes is present in blood and can decompose specific several drugs such as carbapenems and 5-fluorouracil. Because the clinical blood sample can be centrifuged and frozen for storage after blood drawing is difficult to realize, in order to ensure the stability of the drug in the processes of transportation and detection, metabolic enzymes need to be inactivated, and a common method is to add a stabilizer, such as carbapenems, N-methylmorpholine and 5-fluorouracil, into uracil, so that the clinical blood sample is convenient to collect and store in scientific research samples.
In clinical use, a stabilizing agent is generally required to be prepared into a concentrated solution, a certain volume of the concentrated solution is absorbed by using a pipette gun and then the concentrated solution is added into a blood sample, so that a pipette gun is required to be prepared for each blood sampling point, the pipette gun belongs to a precise instrument, for example, patent CN 208894255U discloses a portable pipette gun and a pipette head integrated box, a pipette gun frame and a pipette head integrated box are integrated, the portable pipette gun and the pipette head integrated box are convenient to carry and use, an elastic material is adopted for a pipette gun fixing device, the purpose of protecting the pipette gun can be achieved, but the pipette gun belongs to the precise instrument, so that the price is high, and a blood sampling person can use the pipette gun by a professional trained worker, so that the use cost is greatly increased, and human resources are wasted.
At present, a common storage agent for stabilizing samples in China is stored according to the characteristic that the sample is easy to dissolve in water or an organic solvent according to the dissolution characteristic, but bacteria can grow in an aqueous solution after the aqueous solution is placed for a long time, and the concentration of the organic solvent can be changed due to volatilization of the solvent after the organic solvent is placed for a long time, so that the use of the stabilizing agent is influenced, and the storage of the sample stabilizing agent is particularly important.
When the sample stabilizer is used, the blood sampling cap needs to be opened, so that operators are easily infected by pathogenic microorganisms in the blood sampling cap, and the physical conditions of the operators are damaged.
In summary, the storage mode and the transfer mode of the sample stabilizer in China at present have a series of defects, such as: at present, China has high use cost in a sample stabilizer transferring mode, human resources are wasted, and two lines of defects of the sample stabilizer are easy to exist in storage, a water solution can breed bacteria after being placed for a long time, two organic solvents volatilize due to the solvents after being placed for a long time, concentration can be changed, and when the sample stabilizer is used, a blood sampling cap needs to be opened, an operator is easily infected by pathogenic microorganisms inside, and the problems of harm and the like to the physical condition of the operator are caused. Therefore, the invention of a capillary tube which is convenient to carry, store, move and take and integrally stores and adds a sample stabilizer is urgently needed.
Disclosure of Invention
The invention aims to solve the defects of the prior art and provide a capillary tube which is convenient to carry, store, move and use, is not easy to be infected by pathogenic microorganisms in the capillary tube when in use, and is used for storing and adding a sample stabilizer, which is harmful to the physical condition of workers.
In order to achieve the purpose, the invention provides the following technical scheme: a capillary for storing and adding a sample stabilizer comprises a thin end sealing head, a thick end sealing head, a capillary, a sample stabilizer storage part, a sample stabilizer, a thin end notch, a thin end head, a thick end head and a thick end notch.
Preferably, the capillary can use the difference of medicine to carry out different selections according to actual conditions, the capillary generally chooses transparent glass material to make for, makes the capillary have the visuality, when using photosensitive medicine, the capillary chooses brown glass material to make for use, the capillary slope sets up, the sample stabilizer storage part of capillary is the acute angle with the contained angle of capillary vertical axis.
Preferably, the end face of the left side of the capillary tube is provided with a thin end head, the diameter of the thin end head is 0.3-2mm, the thin end head is arranged in a circular arc shape and is relatively sharp, a rubber pad of an external blood sampling tube cap is punctured, and the thin end face of the thin end head is convenient for puncturing the rubber pad of the external blood sampling tube cap.
Preferably, a thick end is arranged on the end face of the right side of the capillary tube, the thick end 10 is a thick end face, the diameter of the thick end is 1-5mm, and more stabilizer liquid can be stored in the thick end face.
Preferably, the end face of the top of the thin end head is provided with a thin end sealing head, the right side of the thin end sealing head is provided with a thin end nick, and the thin end nick is convenient to break the thin end sealing head.
Preferably, the end face of the top of the thick end head is provided with a thick end sealing head, the left side of the thick end sealing head is provided with a thick end nick, and the thick end sealing head is conveniently broken by the aid of the thick end nick.
Preferably, a sample stabilizer storage part is arranged in the middle of the capillary tube, a sample stabilizer can be stored in the sample stabilizer storage part, and the end faces of the two ends of the sample stabilizer storage part are sealed through a thin end sealing head and a thick end sealing head.
Preferably, the thin end sealing head, the thick end sealing head, the capillary tube, the thin end head, the thick end head and the thick end nick are integrally arranged, and the carrying is convenient.
Compared with the prior art, the invention provides the capillary tube for storing and adding the sample stabilizer, which has the following beneficial effects:
1. capillary middle part is provided with sample stabilizer storage portion, can store the sample stabilizer in the sample stabilizer storage portion, the both ends terminal surface of sample stabilizer storage portion seals the setting through tip head, thick end head, the setting of tip head, thick end head can prevent volatilizing of organic solvent to and place aqueous solution bacterial growing, can place for a long time, can prolong the save time from this.
2. The thin end of the capillary tube is a thin end face, the diameter of the thin end face is 0.3-2mm, the thick end face is a thick end face, the diameter of the thick end face is 1-5mm, the thick end face can be arranged to store more stabilizer liquid, the storage area is increased, the thin end face is arc-shaped and sharp, the broken capillary tube is thin in wall and sharp, so that the rubber pad of the external blood sampling tube cap can be conveniently punctured, the blood sampling cap does not need to be opened, therefore, the condition that an operator is infected by pathogenic microorganisms inside can be avoided, harm to the physical condition of the operator is prevented, the thin end of the capillary tube is a thin end face, so that the rubber pad of the external blood sampling tube cap can be conveniently punctured, the stabilizer is sucked into the blood sampling tube by means of the vacuum inside of the blood sampling tube, and a liquid transferring gun is not needed to be additionally used for transferring, therefore, the use cost can be reduced, and the operation is simpler.
3. The right side of the thin end sealing head is provided with a thin end nick, the left side of the thick end sealing head is provided with a thick end nick, the arrangement of the thick end nick and the thin end nick is convenient for breaking the thick end sealing head and the thin end sealing head, so that the thick end sealing head and the thin end sealing head can be broken by a light bullet when in use, therefore, the operation is simpler, and the workers can be protected from being injured,
4. the thin end sealing head, the thick end sealing head, the capillary tube, the thin end head, the thick end head and the thick end nick are integrally arranged, so that the device is convenient to carry and practical.
Drawings
The accompanying drawings, which are included to provide a further understanding of the invention and are incorporated in and constitute a part of this specification, illustrate embodiments of the invention and together with the description serve to explain the principles of the invention without limiting the invention in which:
FIG. 1 is a schematic diagram of a capillary structure for storing and adding a sample stabilizer according to the present invention;
FIG. 2 is a three-dimensional view of a capillary tube for storing and adding a sample stabilizer according to the present invention;
in the figure: 1. sealing the thin end; 2. sealing a thick end; 4. a capillary tube; 5. a sample stabilizer storage section; 6. a sample stabilizer; 7. scoring the thin end; 9. a thin end; 10. a coarse end is obtained; 11. and (4) scoring the thick end.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Referring to fig. 1-2, the present invention provides the following technical solutions: the invention relates to a capillary for storing and adding a sample stabilizer, which comprises a thin end sealing head 1, a thick end sealing head 2, a capillary 4, a sample stabilizer storage part 5, a sample stabilizer 6, a thin end nick 7, a thin end head 9, a thick end head 10 and a thick end nick 11.
As shown in FIG. 1, the present embodiment provides a capillary for storing and adding a sample stabilizer, characterized in that: capillary 4 can be according to actual conditions, the different materials of different choices of use medicine, capillary 4 can generally choose transparent glass material to make, makes capillary 4 have the visuality, when using photosensitive medicine, capillary 4 chooses brown glass material to make for use, capillary 4 slope sets up, capillary 4's sample stabilizer storage part 5 is the acute angle with the contained angle of capillary 4 axis of ordinates.
As shown in FIG. 1, the present embodiment provides a capillary for storing and adding a sample stabilizer, characterized in that: the left end face of the capillary tube 4 is provided with a thin end head 9, the diameter of the thin end head 9 is 0.3-2mm, the thin end head 9 is arranged in a circular arc shape and is relatively sharp, a rubber pad of an external blood collection tube cap is punctured, and the blood collection cap does not need to be opened.
As shown in FIG. 1, the present embodiment provides a capillary for storing and adding a sample stabilizer, characterized in that: the right end face of the capillary tube 4 is provided with a thick end 10, the thick end 10 is a thick end face, the diameter of the thick end 10 is 1-5mm, and the thick end face 10 can store more stabilizer liquid.
As shown in FIG. 1, the present embodiment provides a capillary for storing and adding a sample stabilizer, characterized in that: the end face of the top of the thin end head 9 is provided with a thin end sealing head 1, the right side of the thin end sealing head is provided with a thin end nick 7, and the thin end nick 7 is convenient for breaking the thin end sealing head 1.
As shown in FIG. 1, the present embodiment provides a capillary for storing and adding a sample stabilizer, characterized in that: the end face of the top of the thick end head 10 is provided with a thick end sealing head 2, the left side of the thick end sealing head is provided with a thick end nick 11, and the thick end nick 11 is convenient to break the thick end sealing head 2.
As shown in FIG. 1, the present embodiment provides a capillary for storing and adding a sample stabilizer, characterized in that: the middle part of the capillary tube is provided with a sample stabilizer storage part 5, a sample stabilizer 6 can be stored in the sample stabilizer storage part 5, and the end faces of the two ends of the sample stabilizer storage part 5 are sealed through a thin end sealing head and a thick end sealing head.
As shown in FIG. 1, the present embodiment provides a capillary for storing and adding a sample stabilizer, characterized in that: the thin end sealing head 1, the thick end sealing head 2, the capillary 4, the thin end head 9, the thick end head 10 and the thick end nick 11 are integrally arranged, and the carrying is convenient.
The invention has the following use process: when the blood collecting tube is used, the thick end face of the right end face of the thick end head 10 of the capillary tube 4 is only required to face downwards to enable the stabilizer to fall into the bottom, if the thin end face of the thin end head 9 of the capillary tube 4 still has the stabilizer, the stabilizer is only required to be flicked by using a finger to fall off, then the thin end head of the thin end head 4 of the capillary tube is broken off and inserted into a test tube cap of a blood sample, at the moment, an external test tube and the capillary tube 4 are kept vertical, the capillary tube is flicked to enable the stabilizer to fall into the thin end head 9 of the capillary tube from the thick end head 10 of the capillary tube 4, then the thin end head 1 of the capillary tube 4 is broken off slightly, at the moment, the stabilizer is sucked into the blood collecting tube by means of vacuum in the external blood collecting tube, finally the capillary tube 4 is pulled out and thrown into an external acute box.
Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.

Claims (8)

1. A capillary for storing and adding a sample stabilizer, comprising: the device comprises a thin end sealing head (1), a thick end sealing head (2), a capillary tube (4), a sample stabilizing agent storage part (5), a sample stabilizing agent (6), a thin end notch (7), a thin end head (9), a thick end head (10) and a thick end notch (11).
2. A capillary for storing and adding a sample stabilizing agent according to claim 1, wherein: capillary (4) can use the difference of medicine to carry out different selections according to actual conditions, capillary (4) generally select transparent glass material to make, make capillary (4) have the visuality, when using photosensitive medicine, capillary (4) select brown glass material to make, capillary (4) slope sets up, the sample stabilizer storage portion (5) of capillary (4) is the acute angle with the contained angle of capillary (4) axis of ordinates.
3. The capillary for storing and adding a sample stabilizing agent according to claim 2, wherein: the left end face of the capillary tube (4) is provided with a thin end head (9), the diameter of the thin end head (9) is 0.3-2mm, the thin end head (9) is arranged in an arc shape, and the thin end face of the thin end head (9) is convenient for pricking a rubber pad of an external blood sampling tube cap.
4. A capillary tube for storing and adding a sample stabilizing agent according to claim 3, wherein: capillary (4) right side terminal surface is provided with thick end (10), thick end (10) are thick terminal surface, thick end (10) diameter is 1-5mm, more stabilizer liquid can be stored in the setting of the thick terminal surface of thick end (10).
5. A capillary for storing and adding a sample stabilizing agent according to claim 1, wherein: thin end head (9) top end face is provided with thin end head (1), thin end head (1) right side is provided with thin end nick (7), the setting of thin end nick (7) is convenient for break off with the fingers and thumb thin end head (1).
6. A capillary for storing and adding a sample stabilizing agent according to claim 1, wherein: the end face of the top of the thick end head (10) is provided with a thick end sealing head (2), the left side of the thick end sealing head (2) is provided with a thick end nick (11), and the thick end nick (11) is convenient to break the thick end sealing head (2) off with the fingers and thumb.
7. A capillary for storing and adding a sample stabilizing agent according to claim 1, wherein: the capillary middle part is provided with sample stabilizer storage portion (5), can store sample stabilizer (6) in sample stabilizer storage portion (5), the both ends terminal surface of sample stabilizer storage portion (5) seals the setting through thin end head (1), butt head (2).
8. A capillary for storing and adding a sample stabilizing agent according to claim 1, wherein: the thin end sealing head (1), the thick end sealing head (2), the capillary tube (4), the thin end head (9), the thick end head (10) and the thick end nick (11) are integrally arranged, and the carrying is convenient.
CN202011267007.1A 2020-11-13 2020-11-13 Capillary tube for storing and adding sample stabilizer Active CN112547144B (en)

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Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2217230A1 (en) * 1971-05-28 1972-12-07 Becton Dickinson Co Method and device for measuring small quantities of a gaseous or liquid sample
JPH07213925A (en) * 1993-12-09 1995-08-15 Fuji Photo Film Co Ltd Fixed volume blood sampling tool
CN1662307A (en) * 2002-05-13 2005-08-31 贝克顿·迪金森公司 Protease inhibitor sample collection system
CN201167960Y (en) * 2008-04-01 2008-12-24 戴伟 Hemostix
CN205084751U (en) * 2015-10-10 2016-03-16 上海旭瀚科技有限公司 Micro -fluidic reagent of biological detection is packaging hardware and sampling device in advance

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2217230A1 (en) * 1971-05-28 1972-12-07 Becton Dickinson Co Method and device for measuring small quantities of a gaseous or liquid sample
JPH07213925A (en) * 1993-12-09 1995-08-15 Fuji Photo Film Co Ltd Fixed volume blood sampling tool
CN1662307A (en) * 2002-05-13 2005-08-31 贝克顿·迪金森公司 Protease inhibitor sample collection system
CN201167960Y (en) * 2008-04-01 2008-12-24 戴伟 Hemostix
CN205084751U (en) * 2015-10-10 2016-03-16 上海旭瀚科技有限公司 Micro -fluidic reagent of biological detection is packaging hardware and sampling device in advance

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