US3645253A - Instrument for the withdrawal of body fluids - Google Patents

Instrument for the withdrawal of body fluids Download PDF

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Publication number
US3645253A
US3645253A US3645253DA US3645253A US 3645253 A US3645253 A US 3645253A US 3645253D A US3645253D A US 3645253DA US 3645253 A US3645253 A US 3645253A
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Prior art keywords
piston
tube
instrument
needle
withdrawal
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Expired - Lifetime
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Bastiaan Cornelis Goverde
Rijkent Hendrik Drost
Bernardus Louwerens
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Organon NV
Organon Inc
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Organon NV
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Detecting, measuring or recording for diagnostic purposes; Identification of persons
    • A61B5/15Devices for taking samples of blood
    • A61B5/150007Details
    • A61B5/150374Details of piercing elements or protective means for preventing accidental injuries by such piercing elements
    • A61B5/150534Design of protective means for piercing elements for preventing accidental needle sticks, e.g. shields, caps, protectors, axially extensible sleeves, pivotable protective sleeves
    • A61B5/15058Joining techniques used for protective means
    • A61B5/150595Joining techniques used for protective means by snap-lock (i.e. based on axial displacement)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Detecting, measuring or recording for diagnostic purposes; Identification of persons
    • A61B5/15Devices for taking samples of blood
    • A61B5/150007Details
    • A61B5/150015Source of blood
    • A61B5/15003Source of blood for venous or arterial blood
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Detecting, measuring or recording for diagnostic purposes; Identification of persons
    • A61B5/15Devices for taking samples of blood
    • A61B5/150007Details
    • A61B5/150206Construction or design features not otherwise provided for; manufacturing or production; packages; sterilisation of piercing element, piercing device or sampling device
    • A61B5/150236Pistons, i.e. cylindrical bodies that sit inside the syringe barrel, typically with an air tight seal, and slide in the barrel to create a vacuum or to expel blood
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Detecting, measuring or recording for diagnostic purposes; Identification of persons
    • A61B5/15Devices for taking samples of blood
    • A61B5/150007Details
    • A61B5/150206Construction or design features not otherwise provided for; manufacturing or production; packages; sterilisation of piercing element, piercing device or sampling device
    • A61B5/150244Rods for actuating or driving the piston, i.e. the cylindrical body that sits inside the syringe barrel, typically with an air tight seal, and slides in the barrel to create a vacuum or to expel blood
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Detecting, measuring or recording for diagnostic purposes; Identification of persons
    • A61B5/15Devices for taking samples of blood
    • A61B5/150007Details
    • A61B5/150206Construction or design features not otherwise provided for; manufacturing or production; packages; sterilisation of piercing element, piercing device or sampling device
    • A61B5/150251Collection chamber divided into at least two compartments, e.g. for division of samples
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Detecting, measuring or recording for diagnostic purposes; Identification of persons
    • A61B5/15Devices for taking samples of blood
    • A61B5/150007Details
    • A61B5/150351Caps, stoppers or lids for sealing or closing a blood collection vessel or container, e.g. a test-tube or syringe barrel
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Detecting, measuring or recording for diagnostic purposes; Identification of persons
    • A61B5/15Devices for taking samples of blood
    • A61B5/150007Details
    • A61B5/150374Details of piercing elements or protective means for preventing accidental injuries by such piercing elements
    • A61B5/150381Design of piercing elements
    • A61B5/150389Hollow piercing elements, e.g. canulas, needles, for piercing the skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Detecting, measuring or recording for diagnostic purposes; Identification of persons
    • A61B5/15Devices for taking samples of blood
    • A61B5/150007Details
    • A61B5/150374Details of piercing elements or protective means for preventing accidental injuries by such piercing elements
    • A61B5/150381Design of piercing elements
    • A61B5/150473Double-ended needles, e.g. used with pre-evacuated sampling tubes
    • A61B5/150496Details of construction of hub, i.e. element used to attach the double-ended needle to a piercing device or sampling device
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Detecting, measuring or recording for diagnostic purposes; Identification of persons
    • A61B5/15Devices for taking samples of blood
    • A61B5/150007Details
    • A61B5/150374Details of piercing elements or protective means for preventing accidental injuries by such piercing elements
    • A61B5/150534Design of protective means for piercing elements for preventing accidental needle sticks, e.g. shields, caps, protectors, axially extensible sleeves, pivotable protective sleeves
    • A61B5/150694Procedure for removing protection means at the time of piercing
    • A61B5/150717Procedure for removing protection means at the time of piercing manually removed
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Detecting, measuring or recording for diagnostic purposes; Identification of persons
    • A61B5/15Devices for taking samples of blood
    • A61B5/150007Details
    • A61B5/150755Blood sample preparation for further analysis, e.g. by separating blood components or by mixing
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Detecting, measuring or recording for diagnostic purposes; Identification of persons
    • A61B5/15Devices for taking samples of blood
    • A61B5/153Devices specially adapted for taking samples of venous or arterial blood, e.g. with syringes
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • B01L3/5082Test tubes per se
    • B01L3/50825Closing or opening means, corks, bungs

Abstract

An improved syringe for the withdrawal of body fluids, especially adapted for transport and storage as well as for the centrifugation of the fluid samples, preferably blood samples, comprises a tube having a hermetically end, the closure of which, being a stopper or cap, is entirely or partly made of resilient material, through which a needle, preferably of stainless steel, extends, which ends in or is tightly pressured against a piston mounted in the tube. Said piston is preferably provided with a concave at the side where the needle ends. Thus a hermetically sealed compartment is obtained through which the needle extends. Said Compartment is suitable for aseptic storage of auxiliaries such as anticoagulants and/or antiseptics.

Description

[ Feb. 29, 1972 United States Patent Goverde et al.

...l28/2l6 X Lockhart...............................l28/216 Sarnoff...............................

i ebfl 5 eha KCL 48574 66645 99999 lllll 1 0111 11 43363 00 08 ,J 660 3 26039 33322 Primary Examiner-Hugh R. Chamblee Att0meyHugo E. Weisberger [22] Filed: Nov. 4, 1969 ABSTRACT [21] Appl. No.:

the withdrawal of body fluids, espe- An improved syringe for cially adapted for transport and storage as well as for the cen- [30] Forelgn Application Priomy Dam trifugation of the fluid samples, preferably blood samples,

ff 00 6.: r mm mm y m a P u r. 0 y We 3 cu Ue ms mm c r g0 HT .1 WW m ms ua t m 8 6 Rb mh 6 mi. h CW 1 2 l 6 1 co S d n a n e h t e N 8 6 9 2 l V. 0 N

ured against a piston mounted in the tube. Said piston is preferably pro- 128/; F, 123/276 resilient material, through which a needle, preferably of stain- Amb 10/00 less steel, extends, which ends in or is tightly press 128/2 F, 2 G; 73/4256 vided with a concave at the side where the needle ends. Thus a hermetically sealed compartment is obtained through which Field ofSearch...................l

I C t H I ll] 00 55 [i References Cited the needle extends. Said Compartment is suitable for aseptic storage of auxiliaries such as anticoagulants and/or antisepti UN lTED STATES PATENTS 3,162,195 Dick... ..................................128/216 7Claims,3Drawing Figures INSTRUMENT FOR THE WIT HDRAWAL OF lBOlDY FLUIDS BACKGROUND OF THE INVENTION An instrument which is frequently applied for drawing body fluids more particularly blood, is a hypodermic syringe. When this syringe is not used for injection purposes, but for taking samples of a body fluid, this fluid after the puncture has to be transferred into a container in order to transport said fluid or to perform clinical-chemical determinations in it. The drawbacks of such a method are obvious as these operations take much time and the chance of mistakes is increased. Moreover, after the use the syringe has to be cleaned and, if necessary or desired, sterilized again and provided with fresh anticoagulants and/or antiseptics.

Of the hypodermic syringes which have been developed so far for the withdrawal of body fluids no variants are known which are also suitable for the storage, the transport and the centrifugation of these fluids.

Since there is at present a strong tendency towards greater efficiency and, connected therewith, greater uniformity of apparatuses to be used in clinical-chemical determinations, the need is felt of a fluid drawing instrument which is also equipped for the transport, the storage and the centrifugation of the fluid.

A partial, but by no means ideal solution of the above-mentioned problems was found in the use of an apparatus comprising the following two essential parts:

1 a vacuum ampoule fitted at one side with a cap or stopper of resilient material;

2. a holder with a needle pointed at both ends in which the vacuum ampoule can be placed.

By means of such an apparatus blood can be taken by inserting the needle into a blood vessel and then exerting pressure on the ampoule so that the needle will pierce the resilient cap of the ampoule. However, such a device is rather expensive, due to the fact that special vacuum ampoules are required. Another great objection is that the movement which has to be made to withdraw the fluid (exerting such a pressure on the vacuum ampoule that the needle will pierce the cap of the ampoule) is essentially contrary to the movement made when an ordinary hypodermic syringe is used. Moreover, so much pressure should be exerted that there is a danger of the needle piercing the vein, which can give rise to hematomae and other injuries. Besides the ampoule cannot be filled up completely there will always remain a certain space above the blood containing air or another gas, in consequence of which undesired changes may occur during the transport of the blood.

SUMMARY OF THE INVENTION An instrument has now been found adapted to be employed for the withdrawal of body fluids. This instrument is also suitable for the transport and the storage of these fluids, as well as for the centrifugation and other preparatory operations prior to the performance of clinical-chemical determinations, to which instrument no such drawbacks as those mentioned above are attached. It can be constructed at such a low cost that after a single use the instrument can be discarded.

The instrument according to the invention is characterized by a tube having one hermetically closed end, the closure of which is entirely or partly made of resilient material, through which material a needle extends which ends in a piston mounted in the tube, which piston is fitted with a device which enables said piston to be moved.

DESCRIPTION OF THE PREFERRED EMBODIMENT The instrument according to the invention is illustrated in FIG. I in the sheet of drawings, representing one of the possible embodiments of the invention.

The process of taking body-fluids with such a device is very simple. The needle is inserted into the body in the conventional manner, after which the fluid is withdrawn by moving the piston backwards. After the puncture the detachable parts of the instrument, including the needle, are removed, after which the body of the instrument, a handy tube, containing a hermetically sealed quantity of fluid, remains. If a specimen of blood has been taken which is to be transported over long distances, for instance, by airmail, the air has to be removed from the tube, because, due to excessive shaking during the transport, hemolysis may be caused. For this purpose the needle is not immediately entirely removed from the tube, but only in part, so that the end of the needle just remains in communication with a concave which should preferably be made in the closure. By moving the piston towards the needle while keeping the tube in a vertical position, the air first collects in the concave, after which it is removed through the needle. Then the needle can be entirely drawn from the closure.

Now, the tube containing the fluid (FIG. lIl) can be stored or transported and, if desired, centrifuged to separate any solid substance from the fluid.

The parts of the instrument according to the invention are illustrated further with reference to FIG. I in the sheet of drawings.

The tube (1 e.g., of cylindrical shape, should preferably be made of transparent material. Tubes made of synthetic material, such for example as polystyrene, acrylstyrene, polypropylene and polymethylpentene or other polyolefins, are very suitable for this purpose. The dimensions and the content of the tube depend, of course, on the purpose for which the instrument according to the invention is used, but it is a prerequisite that the tube should be adapted to be used in the common laboratory centrifuges. For the performance of most clinical-chemical determinations in the blood of adults a blood sample of 10 ml. is sufficient.

At one end the tube is hermetically closed, for example with a cap or a stopper partly or entirely made of resilient material, for example, rubber. There should preferably be a concave (3) in the closure communicating with the interior of the tube, which permits any air present in the tube to be removed easily, as described above. The needle (4) which should be made of durable material, preferably stainless steel, extends through the resilient part of the closure either centrically or eccentrically according to the location of the concave. Moreover, the needle should preferably be fitted with a guard (5) preventing the needle from penetrating further into the tube.

The end of the needle which is in the tube should end in or tightly press against a piston (7). Preferably the needle reaches to the interior of the piston so that on injection it can no more move sidelong. Hence a needle which is pointed at both ends is the most suitable needle to employ in the instrument according to the invention. Thus a perfectly hermetically sealed compartment (6) is obtained, through which the needle extends either centrically or eccentrically.

In the piston there should preferably be a concave at the side where the needle ends, which offers advantages on examination of the sediment obtained after centrifuging, which has collected in the concave. Also, the piston is fitted with, or can be fitted with a device for moving it. For this purpose a piston rod is mostly used. With a view to centrifuging the fluid, the piston rod should be detachable annexed, in any case that part which sticks out of the tube after withdrawal of the fluid. To fulfill this requirement the piston rod can be provided with, for example, a breaking point. However, it is to be preferred to provide the piston with a device (8), for example a screw thread or a catch, to fasten a loose piston rod, but other devices, too, can be used in the instrument according to the invention to move the piston.

The other open end of the tube can be closed with a cap (9), which can be provided with an opening, if desired, through which quite easily a piston rod can be put. For special purposes said opening is closed by a film, for example, of rubber or plastic (10). Such a closure is required if microbiological determinations are to be performed in connection with which not only compartment (6), but the whole inner side of the tube should be sterile.

The part of the needle extending out of the tube can be protected with a cover, which serves a double purpose: it protects the needle and keeps it sterile. The material of which said cover is made should preferably be pervious to sterilizing gases such as ethylene-oxide.

The device according to the invention can be supplied perfectly sterile and is constructed in such a way that the sterility will be maintained for a virtually unlimited time.

To the instrument according to the invention, which is illustrated in FIG. I in the sheet of drawings and which is one of the possible embodiments of the invention, belongs a loose piston rod, which must be mounted on the piston before use. Such a piston rod (FIG. II) can be made of durable material, for example stainless steel. If the sterility should be extremely great on taking the fluid, the piston rod can be sterilized before it is fitted in the tube, for example, by flaming.

The fluid-withdrawal instrument according to the invention is destroyed or discarded after use; a piston rod of durable material can be used over and over again. However, the piston rod can also be made of synthetic material, in which case it is discarded together with the fluid-withdrawal instrument after one-time use. If sterility is required, such a loose piston rod of synthetic material can be manufactured in a sterilized package.

In practice most determinations have been performed in blood serum so far, that is to say, in the fluid that remains after clotting has taken place. The instrument according to the invention enables this serum to be prepared a short time after the puncture and free from hemolysis.

However, a number of determinations in blood are performed starting from whole blood or blood plasma, that is to say, starting from blood which has not been allowed to clot.

Examples of such determinations are: the determination of amino acids, amino-nitrogen, ascorbic acid, lactic acid and al cohol, and further, for example, the hematocrite value, the oxygen-binding capacity, the prothrombin time and the erythrocyte-sedimentation time.

Dependent on the determinations to be performed in blood, the following anticoagulants are often used: sequestering agents such as salts of ethylenediamine-tetraacetic acid, for example, potassium or sodium EDTA, heparin, for example, potassium, sodium or lithium salts, sodium fluoride, sodium citrate, potassium or sodium oxalate or potassium-ammonium oxalate.

Said coagulants, in a solid or in a liquid form, can be passed aseptically into the sterilized device according to the invention, and that into the compartment (6) between the piston and the closure. As the needle presses tightly against or reaches to the interior of the piston, said substances cannot penetrate into the needle so that they cannot constitute a danger to the patient or block up the needle. The instruments according to the invention filled with different coagulants should be clearly distinguishable from each other, for example, by a clear code and/or differences in color.

The following four types of blood withdrawal instruments are suitable for most clinical-chemical determinations:

l. blood-withdrawal instrument having an empty sterile space between stopper and piston;

2. blood-withdrawal instruments having a sequestering agent in the compartment in question, for example, tripotassium EDTA;

3. blood-withdrawal instrument containing heparin in the form of the sodium salt;

4. blood-withdrawal instrument containing sodium citrate.

For determinations to be performed in body fluids other than blood, such as lumber fluid, interarticular fluid and pleural fluid, other auxiliaries such as antiseptics, can be present in the instrument according to the invention. It stands to reason that the nature of the determination to be performed plays a part in the choice of the auxiliary. Likewise the diameter and the length of the needle must be adapted to the field of application.

It is claimed: 1. An instrument for the withdrawal of body fluids comprising a tube having an open end and a hermetically closed opposite end, the interior of said tube being at substantially atmospheric pressure, a closure member at the closed end of the tube providing said hermetic seal which is at least partly made of resilient material through which material a hollow needle extends which terminates in and is sealed by a piston slidably mounted in the interior of said tube provide a hermetically sealed compartment between said closure member and said piston, said compartment being penetrated by said needle, said piston being provided with means for moving the piston away from the closed end of the tube.

2. The instrument of claim 1, in which said closure has a concave communicating with the interior of the tube.

3. The instrument of claim 1, in which said piston possesses a concave portion at the side where the needle terminates in the piston.

4. The instrument of claim 1, in which said piston is fitted with means for fastening a piston rod.

5. The instrument of claim I, in which the open end of said tube is closed with a cap fitted in the middle with a film which can easily be penetrated by a piston rod.

6. The instrument of claim 1 which includes a piston rod attached to said piston.

7. The instrument of claim 1 in which said needle is provided with a guard to prevent further penetration into said tube.

Claims (7)

1. An instrument for the withdrawal of body fluids comprising a tube having an open end and a hermetically closed opposite end, the interior of said tube being at substantially atmospheric pressure, a closure member at the closed end of the tube providing said hermetic seal which is at least partly made of resilient material through which material a hollow needle extends which terminates in and is sealed by a piston slidably mounted in the interior of said tube provide a hermetically sealed compartment between said closure member and said piston, said compartment being penetrated by said needle, said piston being provided with means for moving the piston away from the closed end of the tube.
2. The instrument of claim 1, in which said closure has a concave communicating with the interior of the tube.
3. The instrument of claim 1, in which said piston possesses a concave portion at the side where the needle terminates in the piston.
4. The instrument of claim 1, in which said piston is fitted with means for fastening a piston rod.
5. The instrument of claim 1, in which the open end of said tube is closed with a cap fitted in the middle with a film which can easily be penetrated by a piston rod.
6. The instrument of claim 1 which includes a piston rod attached to said piston.
7. The instrument of claim 1 in which said needle is provided with a guard to prevent further penetration into said tube.
US3645253A 1968-11-12 1969-11-04 Instrument for the withdrawal of body fluids Expired - Lifetime US3645253A (en)

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NL6816121A NL6816121A (en) 1968-11-12 1968-11-12

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US3645253A true US3645253A (en) 1972-02-29

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US (1) US3645253A (en)
JP (1) JPS5014834B1 (en)
DE (1) DE1956953A1 (en)
FR (1) FR2023100A1 (en)
GB (1) GB1282763A (en)
NL (1) NL6816121A (en)

Cited By (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3817239A (en) * 1972-05-12 1974-06-18 D Kuntz Urine monitor
US3885549A (en) * 1972-06-26 1975-05-27 David Thomas Green Apparatus for producing a vacuum in a test tube
US3901219A (en) * 1974-07-25 1975-08-26 Becton Dickinson Co Blood collecting container and method
US4052320A (en) * 1975-08-29 1977-10-04 Eastman Kodak Company Telescoping serum separator and dispenser
EP0029361A2 (en) * 1979-11-19 1981-05-27 Robert Charles Turner Liquid sample collector device
WO1985000662A1 (en) * 1983-07-15 1985-02-14 Radiometer A/S Composition and sampling receptacle method for treating blood with anticoagulant
WO1988002238A1 (en) * 1986-09-30 1988-04-07 William Thomas Dennis Bates Blood sampling device
US4890627A (en) * 1987-11-09 1990-01-02 Habley Medical Technology Corporation Manually evacuated suction tube
WO2003003922A1 (en) * 2001-06-30 2003-01-16 Medizintechnik Promedt Gmbh Blood sample syringe
US20060200073A1 (en) * 2003-07-08 2006-09-07 Novo Nordisk A/S Portable drug delivery device having an encapsulated needle
WO2011050561A1 (en) * 2009-10-30 2011-05-05 天津市百利康泰生物技术有限公司 Disposable rigidly-connected anticoagulant vacuum blood collection needle with collection container and blood outlet
US20120277629A1 (en) * 2011-04-29 2012-11-01 Seventh Sense Biosystems, Inc. Systems and methods for collection and/or manipulation of blood spots or other bodily fluids
WO2013059429A1 (en) * 2011-10-20 2013-04-25 Becton, Dickinson And Company Syringe with removable plunger for arterial blood gas sample collection
WO2013059431A1 (en) * 2011-10-20 2013-04-25 Becton, Dickinson And Company Blood collection assembly
US9033898B2 (en) 2010-06-23 2015-05-19 Seventh Sense Biosystems, Inc. Sampling devices and methods involving relatively little pain
US9041541B2 (en) 2010-01-28 2015-05-26 Seventh Sense Biosystems, Inc. Monitoring or feedback systems and methods
US9113836B2 (en) 2009-03-02 2015-08-25 Seventh Sense Biosystems, Inc. Devices and techniques associated with diagnostics, therapies, and other applications, including skin-associated applications
US9295417B2 (en) 2011-04-29 2016-03-29 Seventh Sense Biosystems, Inc. Systems and methods for collecting fluid from a subject
US9730624B2 (en) 2009-03-02 2017-08-15 Seventh Sense Biosystems, Inc. Delivering and/or receiving fluids

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US4134512A (en) * 1977-06-08 1979-01-16 Becton, Dickinson And Company One-way evacuated tube stopper
US4459997A (en) * 1981-11-03 1984-07-17 Walter Sarstedt Kunststoff-Spritzgusswerk Blood extracting and centrifuging device
US4766908A (en) * 1987-01-12 1988-08-30 Van-Tec, Inc. Aspiration syringe
GB8807132D0 (en) * 1988-03-25 1988-04-27 Bates W T D Sample tube

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US2693183A (en) * 1951-10-10 1954-11-02 Compule Corp Hypodermic syringe blood telltale
US3126004A (en) * 1964-03-24 Cartridge with antipilfering pistojf
US3162195A (en) * 1962-01-02 1964-12-22 Dick Peter Vacuated body fluid collection vial
US3200813A (en) * 1962-12-24 1965-08-17 George J Christakis Aspirating syringes
US3366103A (en) * 1965-06-24 1968-01-30 Becton Dickinson Co Blood collecting assembly

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Publication number Priority date Publication date Assignee Title
US3126004A (en) * 1964-03-24 Cartridge with antipilfering pistojf
US2431406A (en) * 1946-08-30 1947-11-25 Sterling Drug Inc Cartridge-cylinder unit for hypodermic syringes
US2693183A (en) * 1951-10-10 1954-11-02 Compule Corp Hypodermic syringe blood telltale
US3162195A (en) * 1962-01-02 1964-12-22 Dick Peter Vacuated body fluid collection vial
US3200813A (en) * 1962-12-24 1965-08-17 George J Christakis Aspirating syringes
US3366103A (en) * 1965-06-24 1968-01-30 Becton Dickinson Co Blood collecting assembly

Cited By (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3817239A (en) * 1972-05-12 1974-06-18 D Kuntz Urine monitor
US3885549A (en) * 1972-06-26 1975-05-27 David Thomas Green Apparatus for producing a vacuum in a test tube
US3901219A (en) * 1974-07-25 1975-08-26 Becton Dickinson Co Blood collecting container and method
US4052320A (en) * 1975-08-29 1977-10-04 Eastman Kodak Company Telescoping serum separator and dispenser
EP0029361A2 (en) * 1979-11-19 1981-05-27 Robert Charles Turner Liquid sample collector device
EP0029361A3 (en) * 1979-11-19 1982-01-27 Robert Charles Turner Liquid sample collector device
DK152629B (en) * 1979-11-19 1988-03-28 Robert Charles Turner An apparatus for the collection of vaeskeproeve
WO1985000662A1 (en) * 1983-07-15 1985-02-14 Radiometer A/S Composition and sampling receptacle method for treating blood with anticoagulant
WO1988002238A1 (en) * 1986-09-30 1988-04-07 William Thomas Dennis Bates Blood sampling device
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Also Published As

Publication number Publication date Type
NL6816121A (en) 1970-05-14 application
FR2023100A1 (en) 1970-08-07 application
GB1282763A (en) 1972-07-26 application
DE1956953A1 (en) 1970-06-11 application
JPS5014834B1 (en) 1975-05-30 grant

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