CN205084751U - Micro -fluidic reagent of biological detection is packaging hardware and sampling device in advance - Google Patents
Micro -fluidic reagent of biological detection is packaging hardware and sampling device in advance Download PDFInfo
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- CN205084751U CN205084751U CN201520781173.1U CN201520781173U CN205084751U CN 205084751 U CN205084751 U CN 205084751U CN 201520781173 U CN201520781173 U CN 201520781173U CN 205084751 U CN205084751 U CN 205084751U
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Abstract
The utility model relates to a micro -fluidic reagent of biological detection is packaging hardware and sampling device in advance, include: the capillary of medium is encapsulated as reagent in advance, reagent in the capillary encapsulates in advance and adopts water in oil liquid drop encapsulation form, is about to all kinds of reagent and arranges in proper order with the form of water in oil and leave the capillary in, the afterbody of capillary is equipped with piston injection device, and releases each reagent liquid drop from the exit of capillary in proper order through this piston injection device, this micro -fluidic reagent of biological detection is packaging hardware and sampling device in advance has solved the technical problem that the medicament was preserved to combine micro -fluidic chip, make the operation more convenient, realized integrating of kit.
Description
Technical field
The utility model relates to a kind of biological detection microfluidic field, particularly relates to the pre-packaged device of a kind of biological detection microfluidic reagent and sampling device.
Background technology
Biochemistry detection micro-fluidic chip is multifunction system chip, often be referred to as chip lab (Lab-on-a-chip), this chip is formed in integrated for the basic operation units such as the sample preparation involved by biochemistry detection, quantitative sample injection, liquid mixing, biochemical reaction, separation detection or baseset on the chip of several square centimeters, is a kind of technology platform of the various functions replacing conventional chemical or biology laboratory.The essential characteristic of micro-fluidic chip and sharpest edges are by integrated to various monotechnics flexible combination, scale on the small platform that entirety is controlled.Reagent is pre-packaged is the household function that micro-fluidic chip is applied at portable analysis detection field.Current, in existing micro-fluidic chip system, the pre-packaged and long-term preservation method of reagent is often left in the basket.Before microfluidic system operation, the process of liquid needs artificial sample introduction consuming time or the large and immovable sampling device of volume more.Except reagent sample introduction, reliable reagent pre-packaged unlatching mechanism is also very important.Current, how the unlatching of pre-packaged reagent is opened by micro-valve and is realized, and this can not meet the requirement of actual conditions to chip stability and vibration resistance.
Utility model content
The purpose of this utility model is to provide the pre-packaged device of a kind of biological detection microfluidic reagent and sampling device, solves the technical problem that medicament is preserved, and in conjunction with micro-fluidic chip, makes more convenient to operate, achieve the integrated of kit.
In order to solve the problems of the technologies described above, the utility model provides the pre-packaged device of a kind of biological detection microfluidic reagent, comprising: as the capillary of the pre-packaged medium of reagent; Reagent in described capillary pre-packaged employing Water-In-Oil drop packing forms, to be arranged in order with water in oil form by classes of agents and to leave in capillary; The afterbody of described capillary is provided with piston injection device, and each reagent droplet is released from the exit of capillary successively by this piston injection device.
Further, the exit of described capillary is provided with capping.
Another aspect, the utility model additionally provides a kind of biological detection microfluidic reagent sampling device, comprising: micro-fluidic chip and the pre-packaged device of described biological detection microfluidic reagent; The reagent that described micro-fluidic chip flows out for receiving capillary.
Described micro-fluidic chip adopts sandwich construction, and comprises from top to bottom: interface layer, microchannel layers and hybrid reaction layer; Be provided with water-oil separating passage in described interface layer, after being separated by the reagent in Water-In-Oil drop, enter hybrid reaction layer by microchannel layers, and by the oil storage pool on oily introducting interface layer.
The beneficial effects of the utility model are, (1) in capillary, decreases operator's load procedure by pre-packaged for reaction reagent, achieves the integrated of kit; (2) reaction reagent is encapsulated with water in oil form, solve the isolation of different reagent and deposit the space problem avoiding its cross pollution, also solve the problem of the easy volatilizing loss of reagent simultaneously; (3) operator only needs on micro-fluidic chip, add testing sample and insert above-mentioned capillary, can realize hybrid reaction and the detection of testing sample; (4) under the driving of the piston injection device of capillary afterbody, each reaction reagent enters above-mentioned micro-fluidic chip automatically, and realizes mixing automatically and reaction.
Accompanying drawing explanation
Below in conjunction with drawings and Examples, the utility model is further illustrated.
Fig. 1 is the structural representation of the pre-packaged device of biological detection microfluidic reagent of the present utility model;
Fig. 2 is micro-fluidic chip of the present utility model and described biological detection microfluidic reagent pre-packaged device structural representation when being used in combination.
In figure:
The pre-packaged device 1 of biological detection microfluidic reagent, capillary 101, piston injection device 102, capping 103, Water-In-Oil drop 110, oil 111, reagent 112;
Micro-fluidic chip 2, interface layer 210, microchannel layers 220, hybrid reaction layer 230, water-oil separating passage 211, oil storage pool 212, microchannel 221, reaction tank 231.
Detailed description of the invention
By reference to the accompanying drawings the utility model is described in further detail now.These accompanying drawings are the schematic diagram of simplification, only basic structure of the present utility model are described in a schematic way, and therefore it only shows the formation relevant with the utility model.
Embodiment 1
As shown in Figure 1, the pre-packaged device 1 of a kind of biological detection microfluidic reagent of the present utility model, comprising: as the capillary 101 of the pre-packaged medium of reagent; Reagent pre-packaged employing Water-In-Oil drop packing forms in described capillary 101, to be arranged in order with water in oil form by classes of agents and to leave in capillary 101; The afterbody of described capillary 101 is provided with piston injection device 102, and each reagent droplet is released from the exit of capillary 101 successively by this piston injection device 102.
Further, in order to promote the sealing effectiveness of the pre-packaged device 1 of biological detection microfluidic reagent, the exit of described capillary 101 is provided with capping 103.
Embodiment 2
On embodiment 1 basis, the utility model additionally provides a kind of biological detection microfluidic reagent sampling device, comprising: micro-fluidic chip 2 and the pre-packaged device 1 of described biological detection microfluidic reagent; The reagent that described micro-fluidic chip 2 flows out for receiving capillary 101.
Further, described micro-fluidic chip 2 adopts sandwich construction, and comprises from top to bottom: interface layer 210, microchannel layers 220 and hybrid reaction layer 230; Be provided with water-oil separating passage 211 in described interface layer 210, after being separated by the reagent in Water-In-Oil drop, enter hybrid reaction layer 230 by microchannel layers 220, and by the oil storage pool 212 on oily introducting interface layer 210.
Described reagent enters the reaction tank 231 in hybrid reaction layer 230 by the microchannel 221 in microchannel layers 220.
The arranged on left and right sides of described water-oil separating passage 211 is respectively water-wet side, edible vegetable oil side, and after namely Water-In-Oil drop enters interface layer 210, in addition electric field, make its breakdown of emulsion, reagent moves toward water-wet side, and oil moves toward oil-wet side, and then realizes water-oil separating.
With above-mentioned according to desirable embodiment of the present utility model for enlightenment, by above-mentioned description, relevant staff in the scope not departing from this utility model technological thought, can carry out various change and amendment completely.The technical scope of this utility model is not limited to the content on description, must determine its technical scope according to right.
Claims (4)
1. the pre-packaged device of biological detection microfluidic reagent, is characterized in that, comprising: as the capillary of the pre-packaged medium of reagent;
Reagent in described capillary pre-packaged employing Water-In-Oil drop packing forms, to be arranged in order with water in oil form by classes of agents and to leave in capillary;
The afterbody of described capillary is provided with piston injection device, and each reagent droplet is released from the exit of capillary successively by this piston injection device.
2. the pre-packaged device of biological detection microfluidic reagent as claimed in claim 1, it is characterized in that, the exit of described capillary is provided with capping.
3. a biological detection microfluidic reagent sampling device, is characterized in that, comprising: micro-fluidic chip and the pre-packaged device of biological detection microfluidic reagent as claimed in claim 1 or 2;
The reagent that described micro-fluidic chip flows out for receiving capillary.
4. biological detection microfluidic reagent sampling device as claimed in claim 3, is characterized in that, described micro-fluidic chip adopts sandwich construction, and comprises from top to bottom: interface layer, microchannel layers and hybrid reaction layer;
Be provided with water-oil separating passage in described interface layer, after being separated by the reagent in Water-In-Oil drop, enter hybrid reaction layer by microchannel layers, and by the oil storage pool on oily introducting interface layer.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201520781173.1U CN205084751U (en) | 2015-10-10 | 2015-10-10 | Micro -fluidic reagent of biological detection is packaging hardware and sampling device in advance |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN201520781173.1U CN205084751U (en) | 2015-10-10 | 2015-10-10 | Micro -fluidic reagent of biological detection is packaging hardware and sampling device in advance |
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| CN205084751U true CN205084751U (en) | 2016-03-16 |
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| CN201520781173.1U Expired - Fee Related CN205084751U (en) | 2015-10-10 | 2015-10-10 | Micro -fluidic reagent of biological detection is packaging hardware and sampling device in advance |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110470808A (en) * | 2018-05-11 | 2019-11-19 | 中国石油化工股份有限公司 | Water quality many reference amounts detection device and detection method based on manual injector |
| CN110470511A (en) * | 2018-05-11 | 2019-11-19 | 中国石油化工股份有限公司 | Manual injector and hand sampling method and its application for sample pretreatment |
| CN110470601A (en) * | 2018-05-11 | 2019-11-19 | 中国石油化工股份有限公司 | Water quality many reference amounts detection device and detection method based on chip reaction unit |
| CN110465336A (en) * | 2018-05-11 | 2019-11-19 | 中国石油化工股份有限公司 | Chip reaction unit and hand sampling method and its application |
| CN112547144A (en) * | 2020-11-13 | 2021-03-26 | 青岛大学附属医院 | Capillary tube for storing and adding sample stabilizer |
-
2015
- 2015-10-10 CN CN201520781173.1U patent/CN205084751U/en not_active Expired - Fee Related
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110470808A (en) * | 2018-05-11 | 2019-11-19 | 中国石油化工股份有限公司 | Water quality many reference amounts detection device and detection method based on manual injector |
| CN110470511A (en) * | 2018-05-11 | 2019-11-19 | 中国石油化工股份有限公司 | Manual injector and hand sampling method and its application for sample pretreatment |
| CN110470601A (en) * | 2018-05-11 | 2019-11-19 | 中国石油化工股份有限公司 | Water quality many reference amounts detection device and detection method based on chip reaction unit |
| CN110465336A (en) * | 2018-05-11 | 2019-11-19 | 中国石油化工股份有限公司 | Chip reaction unit and hand sampling method and its application |
| CN112547144A (en) * | 2020-11-13 | 2021-03-26 | 青岛大学附属医院 | Capillary tube for storing and adding sample stabilizer |
| CN112547144B (en) * | 2020-11-13 | 2022-04-26 | 青岛大学附属医院 | Capillary tube for storing and adding sample stabilizer |
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| Date | Code | Title | Description |
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| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20160316 Termination date: 20191010 |
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| CF01 | Termination of patent right due to non-payment of annual fee |