CN112545913A - Anti-hair loss shampoo containing nano composition and preparation method thereof - Google Patents
Anti-hair loss shampoo containing nano composition and preparation method thereof Download PDFInfo
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- CN112545913A CN112545913A CN202011488058.7A CN202011488058A CN112545913A CN 112545913 A CN112545913 A CN 112545913A CN 202011488058 A CN202011488058 A CN 202011488058A CN 112545913 A CN112545913 A CN 112545913A
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- 239000000203 mixture Substances 0.000 title claims abstract description 103
- 239000002453 shampoo Substances 0.000 title claims abstract description 81
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- 229940073499 decyl glucoside Drugs 0.000 claims abstract description 41
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- SKQIRRPTHXKMFU-UHFFFAOYSA-N N1(CCCC1)C1=[N+](C(=CC(=N1)N)N)[O-] Chemical compound N1(CCCC1)C1=[N+](C(=CC(=N1)N)N)[O-] SKQIRRPTHXKMFU-UHFFFAOYSA-N 0.000 claims description 16
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- YIWGJFPJRAEKMK-UHFFFAOYSA-N 1-(2H-benzotriazol-5-yl)-3-methyl-8-[2-[[3-(trifluoromethoxy)phenyl]methylamino]pyrimidine-5-carbonyl]-1,3,8-triazaspiro[4.5]decane-2,4-dione Chemical compound CN1C(=O)N(c2ccc3n[nH]nc3c2)C2(CCN(CC2)C(=O)c2cnc(NCc3cccc(OC(F)(F)F)c3)nc2)C1=O YIWGJFPJRAEKMK-UHFFFAOYSA-N 0.000 description 1
- OUNZARDETXBPIX-UHFFFAOYSA-N 2-(2-dodecoxyethoxy)acetic acid Chemical compound CCCCCCCCCCCCOCCOCC(O)=O OUNZARDETXBPIX-UHFFFAOYSA-N 0.000 description 1
- OYINQIKIQCNQOX-UHFFFAOYSA-M 2-hydroxybutyl(trimethyl)azanium;chloride Chemical compound [Cl-].CCC(O)C[N+](C)(C)C OYINQIKIQCNQOX-UHFFFAOYSA-M 0.000 description 1
- HIQIXEFWDLTDED-UHFFFAOYSA-N 4-hydroxy-1-piperidin-4-ylpyrrolidin-2-one Chemical compound O=C1CC(O)CN1C1CCNCC1 HIQIXEFWDLTDED-UHFFFAOYSA-N 0.000 description 1
- XVMSFILGAMDHEY-UHFFFAOYSA-N 6-(4-aminophenyl)sulfonylpyridin-3-amine Chemical compound C1=CC(N)=CC=C1S(=O)(=O)C1=CC=C(N)C=N1 XVMSFILGAMDHEY-UHFFFAOYSA-N 0.000 description 1
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 description 1
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- NEAPKZHDYMQZCB-UHFFFAOYSA-N N-[2-[4-[2-(2,3-dihydro-1H-inden-2-ylamino)pyrimidin-5-yl]piperazin-1-yl]ethyl]-2-oxo-3H-1,3-benzoxazole-6-carboxamide Chemical compound C1CN(CCN1CCNC(=O)C2=CC3=C(C=C2)NC(=O)O3)C4=CN=C(N=C4)NC5CC6=CC=CC=C6C5 NEAPKZHDYMQZCB-UHFFFAOYSA-N 0.000 description 1
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- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 1
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- MTNDZQHUAFNZQY-UHFFFAOYSA-N imidazoline Chemical compound C1CN=CN1 MTNDZQHUAFNZQY-UHFFFAOYSA-N 0.000 description 1
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Images
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
- A61K8/604—Alkylpolyglycosides; Derivatives thereof, e.g. esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
- A61K8/4953—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom containing pyrimidine ring derivatives, e.g. minoxidil
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
- A61Q5/008—Preparations for oily hair
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
- A61Q5/02—Preparations for cleaning the hair
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q7/00—Preparations for affecting hair growth
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/41—Particular ingredients further characterized by their size
- A61K2800/413—Nanosized, i.e. having sizes below 100 nm
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/74—Biological properties of particular ingredients
- A61K2800/78—Enzyme modulators, e.g. Enzyme agonists
- A61K2800/782—Enzyme inhibitors; Enzyme antagonists
Abstract
The invention relates to the technical field of functional washing and caring products, in particular to an anti-hair loss shampoo containing a nano composition and a preparation method thereof. The preparation raw materials comprise, by weight, 0.0001-20 parts of a nanometer anti-dropping composition, 0.1-30 parts of decyl glucoside, 0.001-10 parts of caprylyl glycine, 5-90 parts of water, 1-50 parts of an anionic surfactant, 1-30 parts of a zwitterionic surfactant and 0.01-10 parts of a cationic polymer. Because the non-ionic surfactant decyl glucoside is added in the formula, the invention can provide good foaming performance and effectively remove scalp grease; due to the addition of the nano composition with the anti-hair loss effect, the nano composition can effectively permeate into the deep parts of the scalp and hair follicles, and has good anti-hair loss effect; due to the addition of the oil control component capryloyl glycine, the secretion of oil on the surface of the scalp can be effectively controlled, and the healthy scalp state can be maintained.
Description
Technical Field
The invention relates to the technical field of functional washing and caring products, in particular to an anti-hair loss shampoo containing a nano composition and a preparation method thereof.
Background
With the continuous development of society, people have great changes in daily life, work and rest, stress level and eating habits, and the number of people suffering from alopecia is increased rapidly and the people are young. According to the data of the world health organization, the alopecia rate of Chinese men reaches 20 percent, and the alopecia rate before 30 years old is more than 84 percent. Meanwhile, investigation shows that the alopecia population accounts for a higher degree than the normal population and is depressed due to the negative influence of the alopecia on the appearance. In order to solve the problem, various anti-hair loss cosmetics appear in the market, wherein the most common anti-hair loss shampoo is anti-hair loss shampoo. However, the commercially available anti-hair loss shampoo has a common problem that the anti-hair loss active ingredients contained in the product are not easily absorbed by hair follicles and scalps, so that the corresponding anti-hair loss effect cannot be achieved.
Statistically, 95% of patients with alopecia belong to seborrheic alopecia. Seborrheic alopecia is often accompanied by problems of excess secretion of lipids. Excessive secretion of oil will cause the hair follicle to become clogged, and in the worst case, hair loss will result. Therefore, it is important to achieve good anti-alopecia effect and control scalp oil secretion.
In addition, shampoo as a rinse-off product has a limited time to act on the scalp, and after rinsing with water, the active ingredients are lost with the water and are not substantially retained. Therefore, retention and absorption of active ingredients are critical to the anti-alopecia effect.
Disclosure of Invention
In view of the above technical problems, the first aspect of the present invention provides an anti-hair loss shampoo containing a nano composition, which comprises, by weight, 0.0001 to 20 parts of the nano anti-hair loss composition, 0.1 to 30 parts of decyl glucoside, 0.001 to 10 parts of caprylyl glycine, 5 to 90 parts of water, 1 to 50 parts of an anionic surfactant, 1 to 30 parts of a zwitterionic surfactant, and 0.01 to 10 parts of a cationic polymer.
As a preferable technical scheme, the preparation raw materials also comprise 0.1-20 parts of conditioner and/or 0.01-10 parts of preservative and/or 0.01-10 parts of essence.
As a preferable technical scheme of the invention, the weight ratio of decyl glucoside to caprylyl glycine is (1-3): 1.
as a preferable technical scheme of the invention, the weight ratio of the decyl glucoside to the caprylyl glycine is 2: 1.
as a preferred technical scheme, the nanometer anti-dropping composition comprises nanometer diaminopyrimidine oxide and nanometer pyrrolidinyl diaminopyrimidine oxide.
In a preferred embodiment of the present invention, the nano anti-shedding composition further comprises a glycerin fatty acid ester.
In a preferred embodiment of the present invention, the glycerin fatty acid ester is polyglycerin distearate.
As a preferable technical scheme of the invention, the nanometer anti-dropping composition further comprises 0.1-30 wt% of polyalcohol.
As a preferable technical scheme of the invention, the weight ratio of the anionic surfactant to the zwitterionic surfactant is (2-3): 1.
the invention provides a preparation method of the anti-hair loss shampoo containing the nano composition, which comprises the following steps:
(1) adding water into the main mixing tank at normal temperature, adding the zwitterionic surfactant, and uniformly stirring;
(2) adding a cationic polymer, uniformly stirring, heating to 80-90 ℃;
(3) adding anionic surfactant, keeping the temperature at 80-90 deg.C, and stirring until completely dissolved;
(4) cooling to below 50 deg.C, adding decyl glucoside, and stirring;
(5) adding a conditioner, stirring uniformly, adding the nano composition, stirring uniformly, and adding the rest raw materials.
Has the advantages that: according to the invention, the mild cleaning component, the oil control component and the nano-scale anti-hair loss composition are innovatively added into the shampoo formula, and the mild cleaning component can mildly and effectively remove grease in the deep parts of the scalp and hair follicles in the process of rubbing and cleaning the shampoo and the scalp. Then, after the scalp and hair follicles are cleaned, the nanometer anti-hair loss active ingredients can be adsorbed and permeate into the deep parts of the scalp and hair follicles, thereby exerting the anti-hair loss effect to the maximum extent. Meanwhile, due to the fact that the oil control component is added in the formula, scalp grease secretion can be effectively inhibited, the possibility of alopecia is reduced, and meanwhile the trichopore of the anti-hair loss shampoo cannot be blocked before the anti-hair loss shampoo is used next time.
Drawings
FIG. 1 is a graph showing the results of foam testing in examples of the present application and comparative examples.
Detailed Description
The technical features of the technical solutions provided by the present invention will be further clearly and completely described below with reference to the specific embodiments, and it should be apparent that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
The words "preferred", "preferably", "more preferred", and the like, in the present invention, refer to embodiments of the invention that may provide certain benefits, under certain circumstances. However, other embodiments may be preferred, under the same or other circumstances. Furthermore, the recitation of one or more preferred embodiments does not imply that other embodiments are not useful, nor is it intended to exclude other embodiments from the scope of the invention.
It should be understood that other than in any operating examples, or where otherwise indicated, all numbers expressing, for example, quantities of ingredients used in the specification and claims are to be understood as being modified in all instances by the term "about".
The invention provides an anti-hair loss shampoo containing a nano composition, which comprises, by weight, 0.0001-20 parts of the nano anti-hair loss composition, 0.1-30 parts of decyl glucoside, 0.001-10 parts of caprylyl glycine, 5-90 parts of water, 1-50 parts of an anionic surfactant, 1-30 parts of a zwitterionic surfactant and 0.01-10 parts of a cationic polymer.
The decyl glucoside described in the present invention is also known as decyl octyl glucoside, CAS: 68515-73-1. The raw material for preparing the hair loss prevention shampoo containing the nano composition comprises 0.1-30 parts by weight of decyl glucoside; preferably, it contains 0.5 to 10 parts by weight of decyl glucoside. In the process of using the shampoo, the anti-hair loss shampoo can be in full contact with the scalp in a specific time due to mechanical rubbing and foaming. The nonionic surfactant has strong surface tension reducing ability, low critical micelle concentration, and is mild and easy to wash, due to the addition of decyl glucoside as a mild cleansing ingredient. And the shampoo has good compatibility with various anionic surfactants and zwitterionic surfactants, and can remove scalp and hair follicle grease without causing discomfort to the scalp. The applicant finds that decyl glucoside in the application effectively improves the penetration of active ingredients such as a nano anti-hair-loss composition in shampoo into the scalp through interaction with other components, and remarkably improves the anti-hair-loss effect. Moreover, the same effect can not be achieved by any nonionic surfactant or glucoside with any structure, and the decyl glucoside contains ten carbon atoms in a hydrophobic chain, and the carbon chain length of the decyl glucoside is just matched with that of most anionic surfactants used in the personal care product industry, so that the decyl glucoside can be easily inserted into mixed micelles formed by the anionic surfactants and the zwitterionic surfactants, the surface tension reducing efficiency of the anionic surfactants is greatly improved, and the cleaning capability of the anionic and zwitterionic surfactants is more effectively exerted. Meanwhile, decyl glucoside, as a novel green surfactant, is 100% of natural source and 100% biodegradable. The addition of the substance can greatly improve the biodegradability and the environmental friendliness of the whole formula.
The caprylyl glycine described in the present invention is also known as CAS: 14246-53-8. The preparation raw materials of the anti-hair loss shampoo containing the nano composition comprise 0.001-10 parts by weight of caprylyl glycine; preferably, it contains 0.1 to 1 part by weight of caprylyl glycine. The composition has good oil control effect, can effectively prevent scalp grease from excessively secreting to block pores, and provides good conditions for daily use of an anti-drop smearing type product. Because only the hair follicle is not blocked, the active ingredients of the anti-hair loss resident product can normally permeate in daily use.
In some embodiments, the weight ratio of decyl glucoside to caprylyl glycine is (1-3): 1; preferably, the weight ratio of decyl glucoside to caprylyl glycine is 2: 1. The applicant finds that when decyl glucoside and caprylyl glycine are used in a weight ratio of 2:1, the user experience can be improved more remarkably, the user experience can be made more refreshing, and the anti-dropping effect of the product can be exerted to the maximum extent.
The nanometer anti-hair-loss composition is a component for regulating normal growth factors and cytokines so as to balance the hair growth cycle and further realize the anti-hair-loss effect. The anti-falling resident product containing the nano composition comprises 0.0001-20 parts by weight of the nano anti-falling composition; further, the composition comprises 0.05-10 parts by weight of the nanometer anti-dropping composition; further, the nanometer anti-dropping composition comprises 0.05-3 parts by weight of the nanometer anti-dropping composition.
In some embodiments, the nano anti-shedding composition comprises nanoscale diaminopyrimidine oxide.
The nanoscale diaminopyrimidine oxide as used in the present invention means a diaminopyrimidine oxide having a molecular size of the order of nanometers. The chemical name of the diaminopyrimidine oxide is 2, 4-diaminopyrimidine-3-oxide, the structure of the diaminopyrimidine oxide is similar to that of minoxidil, but the action principle is different. The main mechanism of diaminopyrimidine oxide is to inhibit the production of collagen around hair follicles, to avoid fibrosis, and also to be a potassium channel opener. Diaminopyrimidine oxides are cosmetically approved raw materials and are effective at low dosages. The nanometer anti-falling composition comprises 0.1-15 wt% of diaminopyrimidine oxide; further, the composition contains 0.5-10 wt% of diaminopyrimidine oxide.
Further preferably, the nano anti-shedding composition of the present invention further comprises a nano pyrrolidinyl diaminopyrimidine oxide.
The nanoscale pyrrolidinyl diaminopyrimidine oxide of the present invention can provide nutrients necessary for hair growth by relaxing blood vessels around hair follicles, thereby promoting the transformation of hair from the telogen phase to the anagen phase and maintaining the anagen phase for a longer period of time, thereby promoting hair growth. The nanometer anti-dropping composition comprises 0.1-13 wt% of pyrrolidinyl diaminopyrimidine oxide; further comprises 0.5-8 wt% of pyrrolidinyl diaminopyrimidine oxide. However, since pyrrolidinyl diaminopyrimidine oxide is a crystalline powder, it has poor water solubility and low bioavailability, and the dissolution rate becomes a major limiting factor for drug absorption.
After scalp pathogenic bacteria and grease are controlled, the nanometer anti-hair loss composition begins to go deep into the scalp and hair follicles, contains diaminopyrimidine oxide and pyrrolidinyl diaminopyrimidine oxide, and two bioactive molecules can effectively inhibit the activity of 5 alpha-reductase, so that the secretion of abnormal growth factors in dermal hair papilla and bulge stem cells is reduced, normal growth factors and cytokines are adjusted, the hair growth cycle is balanced, and the anti-hair loss effect is achieved.
More preferably, the nanometer anti-dropping composition also comprises glycerin fatty acid ester and/or 0.1-30 wt% of polyalcohol.
More preferably, the glycerin fatty acid ester is polyglyceryl distearate; more preferably, the polyglyceryl distearate is polyglyceryl-10 distearate. The nanometer anti-dropping composition comprises 0.1-10 wt% of polyglycerol-10 distearate; further preferably, the nanometer anti-dropping composition comprises 0.5-8 wt% of polyglycerol-10 distearate. In some preferred embodiments, the nano anti-shedding composition further comprises small molecule polyol or other alcohol compounds in balance. The kind and ratio of the small molecule polyol are not particularly limited, and examples include, but are not limited to, glycerol, propylene glycol, ethanol, and the like.
After the scalp is cleaned, the hair follicle is opened, which provides a convenient condition for the nano-scale anti-hair loss composition to penetrate deeply into the scalp. The nanometer anti-hair loss composition has small particle size of 10-300 nm, so that the active particle is easy to penetrate and the hair follicle is in open state, so that the nanometer composition can penetrate into the deep part of scalp and hair follicle effectively to reach the effect of preventing hair loss.
The anionic surfactant in the present invention is a surfactant having a hydrophilic group and a hydrophobic group in a molecular chain structure and capable of generating a hydrophobic anion in water. Specific types of the anionic surfactant are not particularly limited, and may include, but are not limited to, sulfonate surfactants, carboxylate surfactants, and sulfate anionic surfactants. Examples of the sulfonate surfactant or carboxylate surfactant include alkyl sulfosuccinates, polyoxyalkylene alkyl sulfosuccinates, higher fatty acid salts, alkanesulfonates, alkyl ether carboxylic acids and salts thereof. Examples of the sulfuric acid-based anionic surfactant include polyoxyethylene alkyl ether sulfate, polyoxyethylene alkenyl ether sulfate, alkyl sulfate, polyoxyalkylene alkyl phenyl ether sulfate, sodium laureth sulfate, and the like.
Among these, preferred are sulfuric acid-based anionic surfactants, and more preferred are sulfuric acid-based anionic surfactants represented by the following general formula (1) or (2). R1O(CH2CH2O)mSO3M(1)、R2OSO3M (2) wherein R1Represents an alkyl or alkenyl group having 10 to 18 carbon atoms, R2An alkyl group having 10 to 18 carbon atoms, M an alkali metal, an alkaline earth metal, ammonium, an alkanolamine or a basic amino acid, and M is 1 to 5 on a weight average basis, and may be sodium laureth-6 carboxylate or the like. The anionic surfactant in the invention can also be amino acid system anionic surfactant, such as sodium cocoyl glutamate or sodium methyl cocoyl taurate.
The amphoteric surfactant in the present invention refers to a surfactant having both ionic properties. However, the amphoteric surfactant is a surfactant composed of an anion and a cation, that is, a surfactant having a cation and an anion at a hydrophilic group terminal and being combined together. The specific type of the amphoteric surfactant is not particularly limited in the present invention, and various amphoteric surfactants known to those skilled in the art may be selected, for example, betaine type zwitterionic surfactants such as cocamidopropyl betaine; imidazoline type zwitterionic surfactants, and the like.
In some embodiments, the weight ratio of the anionic surfactant to the zwitterionic surfactant is (2-3): 1; further preferably, the weight ratio of the anionic surfactant to the zwitterionic surfactant is 2.5: 1. the applicant finds that the anti-hair loss shampoo preparation raw materials containing the nano composition have obvious functional interdependence relationship, and the functions of the shampoo can be optimized only when the components of the components and the proportion thereof reach the required balance, particularly when the anionic surfactant is sodium cocoyl glutamate and sodium laureth sulfate in equal weight, and the zwitterionic surfactant is cocamidopropyl betaine, the synergistic effect of the anionic surfactant and the sodium laureth sulfate is optimal.
The cationic polymer in the invention is a polymer which can be ionized to generate cations in water and exists in the structure. The cationic polymer is not particularly limited in the present invention, and various cationic polymers known to those skilled in the art can be selected, including but not limited to polyquaternium-10, polyquaternium-6, guar hydroxypropyltrimonium chloride, etc.
In some embodiments, the raw materials for preparing the composition further comprise 0.1-20 parts of a conditioning agent and/or 0.01-10 parts of a preservative and/or 0.01-10 parts of a essence.
The specific type of the conditioning agent is not particularly limited in the present invention, and polydimethylsiloxane, grease, and the like can be selected. The oil or fat may be a synthetic oil or fat such as isopropyl myristate, or a natural oil or fat such as jojoba oil or sunflower seed oil.
Under the premise of not influencing the efficacy and other properties of the shampoo, other auxiliary agents can be added, such as pearlescent ingredients, for example, ethylene glycol distearate; in addition, an antidandruff agent such as zinc pyrithione and piroctone olamine can be added into the system to improve the antidandruff and antipruritic effects of the formula.
In the shampoo, decyl glucoside is matched with an anionic surfactant and a zwitterionic surfactant, so that the shampoo is mild and clean, removes grease of scalp and hair follicle, and gets through the hair follicle; then, the nanometer anti-hair-loss composition with the tiny particle size deeply permeates into the scalp and hair follicles to play the effects of preventing hair loss and growing hair in the hair washing and massaging process; finally, caprylyl glycine plays a good role in controlling oil, and can ensure that scalp hair follicles cannot generate excessive oil accumulation before the next use; meanwhile, good conditions are provided for daily use of resident smearing type anti-hair loss essence or spraying, and because the hair follicles are not blocked by grease, the resident smearing type anti-hair loss essence or the active ingredients of spraying can normally permeate. The components are added into the anti-hair-loss shampoo in a combined manner, so that the anti-hair-loss effect of the shampoo is ensured to be exerted to the maximum extent, and good conditions are provided for smearing resident anti-hair-loss essence or spraying products in daily use.
The invention provides a preparation method of the anti-hair loss shampoo containing the nano composition, which comprises the following steps:
(1) adding water into the main mixing tank at normal temperature, adding the zwitterionic surfactant, and uniformly stirring;
(2) adding a cationic polymer, uniformly stirring, heating to 80-90 ℃;
(3) adding anionic surfactant, keeping the temperature at 80-90 deg.C, and stirring until completely dissolved;
(4) cooling to below 50 deg.C, adding decyl glucoside, and stirring;
(5) adding a conditioner, stirring uniformly, adding the nano composition, stirring uniformly, and adding the rest raw materials.
The present invention will be specifically described below by way of examples. It should be noted that the following examples are only for illustrating the present invention and should not be construed as limiting the scope of the present invention, and that the insubstantial modifications and adaptations of the present invention by those skilled in the art based on the above disclosure are still within the scope of the present invention.
Examples
Example 1: the embodiment provides an anti-hair loss shampoo containing a nano composition, which comprises 16 parts of the nano anti-hair loss composition, 1 part of decyl glucoside, 0.5 part of caprylyl glycine, 5 parts of water, 30 parts of an anionic surfactant, 12 parts of a zwitterionic surfactant, 6 parts of a cationic polymer, 3 parts of a conditioner, 1 part of a preservative and 0.8 part of a essence in parts by weight. The nanometer anti-falling composition consists of 10 wt% of nanometer diaminopyrimidine oxide, 4 wt% of nanometer pyrrolidinyl diaminopyrimidine oxide, 6 wt% of polyglycerol-10 diisostearate and the balance of glycerol, propylene glycol and ethanol (equal to the weight of the three components); the anionic surfactant is sodium cocoyl glutamate and sodium laureth sulfate which are equal in weight; the zwitterionic surfactant is cocamidopropyl betaine; the cationic polymer is polyquaternium-10; the conditioner is jojoba oil.
The preparation method of the shampoo comprises the following steps:
(1) adding water into the main mixing tank at normal temperature, adding the zwitterionic surfactant, and uniformly stirring;
(2) adding a cationic polymer, uniformly stirring, heating to 90 ℃;
(3) adding anionic surfactant, keeping the temperature at 90 ℃, and stirring until the anionic surfactant is completely dissolved;
(4) cooling to below 50 deg.C, adding decyl glucoside, and stirring;
(5) adding a conditioner, stirring uniformly, adding the nano composition, stirring uniformly, and adding the rest raw materials.
The applicant carried out tests on the basic technical parameters of the anti-hair loss shampoo containing the nano-composition, and the results are shown in the following table 1:
TABLE 1
From the experimental test results, the shampoo provided by the invention has excellent high and low temperature stability, and does not deteriorate after being stored for a long time.
Example 2: the embodiment provides an anti-hair loss shampoo containing a nano composition, which comprises 16 parts of the nano anti-hair loss composition, 1 part of decyl glucoside, 5 parts of water, 30 parts of an anionic surfactant, 12 parts of a zwitterionic surfactant, 6 parts of a cationic polymer, 3 parts of a conditioner, 1 part of a preservative and 0.8 part of a essence in parts by weight. The nanometer anti-falling composition consists of 10 wt% of nanometer diaminopyrimidine oxide, 4 wt% of nanometer pyrrolidinyl diaminopyrimidine oxide, 6 wt% of polyglycerol-10 diisostearate and the balance of glycerol, propylene glycol and ethanol (equal to the weight of the three components); the anionic surfactant is sodium cocoyl glutamate and sodium laureth sulfate which are equal in weight; the zwitterionic surfactant is cocamidopropyl betaine; the cationic polymer is polyquaternium-10; the conditioner is jojoba oil.
The preparation method of the shampoo comprises the following steps:
(1) adding water into the main mixing tank at normal temperature, adding the zwitterionic surfactant, and uniformly stirring;
(2) adding a cationic polymer, uniformly stirring, heating to 90 ℃;
(3) adding anionic surfactant, keeping the temperature at 90 ℃, and stirring until the anionic surfactant is completely dissolved;
(4) cooling to below 50 deg.C, adding decyl glucoside, and stirring;
(5) adding a conditioner, stirring uniformly, adding the nano composition, stirring uniformly, and adding the rest raw materials.
Example 3: this example provides a container comprisingThe anti-hair loss shampoo with the nano composition comprises, by weight, 16 parts of the nano anti-hair loss composition, 0.5 part of caprylyl glycine, 5 parts of water, 30 parts of an anionic surfactant, 12 parts of a zwitterionic surfactant, 6 parts of a cationic polymer, 3 parts of a conditioner, 1 part of a preservative and 0.8 part of essence. The nanometer anti-falling composition consists of 10 wt% of nanometer diaminopyrimidine oxide, 4 wt% of nanometer pyrrolidinyl diaminopyrimidine oxide, 6 wt% of polyglycerol-10 diisostearate and the balance of glycerol, propylene glycol and ethanol (equal to the weight of the three components); the anionic surfactant is sodium cocoyl glutamate and sodium laureth sulfate which are equal in weight; the zwitterionic surfactant is cocamidopropyl betaine; the cationic polymer is polyquaternium-10; the conditioner is jojoba oil.
The preparation method of the shampoo comprises the following steps:
(1) adding water into the main mixing tank at normal temperature, adding the zwitterionic surfactant, and uniformly stirring;
(2) adding a cationic polymer, uniformly stirring, heating to 90 ℃;
(3) adding anionic surfactant, keeping the temperature at 90 ℃, and stirring until the anionic surfactant is completely dissolved;
(4) cooling to below 50 deg.C, adding conditioner, stirring, adding the nanometer composition, stirring, and adding the rest raw materials.
Example 4: the embodiment provides an anti-hair loss shampoo containing a nano composition, which comprises 16 parts of the nano anti-hair loss composition, 1 part of decyl glucoside, 25 parts of caprylyl glycine, 5 parts of water, 30 parts of an anionic surfactant, 12 parts of a zwitterionic surfactant, 6 parts of a cationic polymer, 3 parts of a conditioner, 1 part of a preservative and 0.8 part of a essence in parts by weight. The nanometer anti-falling composition consists of 10 wt% of nanometer diaminopyrimidine oxide, 4 wt% of nanometer pyrrolidinyl diaminopyrimidine oxide, 6 wt% of polyglycerol-10 diisostearate and the balance of glycerol, propylene glycol and ethanol (equal to the weight of the three components); the anionThe surfactant is sodium cocoyl glutamate and sodium laureth sulfate with equal weight; the zwitterionic surfactant is cocamidopropyl betaine; the cationic polymer is polyquaternium-10; the conditioner is jojoba oil.
The preparation method of the shampoo comprises the following steps:
(1) adding water into the main mixing tank at normal temperature, adding the zwitterionic surfactant, and uniformly stirring;
(2) adding a cationic polymer, uniformly stirring, heating to 90 ℃;
(3) adding anionic surfactant, keeping the temperature at 90 ℃, and stirring until the anionic surfactant is completely dissolved;
(4) cooling to below 50 deg.C, adding decyl glucoside, and stirring;
(5) adding a conditioner, stirring uniformly, adding the nano composition, stirring uniformly, and adding the rest raw materials.
Example 5: the embodiment provides an anti-hair loss shampoo containing a nano composition, which comprises 16 parts of the nano anti-hair loss composition, 1 part of stearoyl glucoside, 0.5 part of caprylyl glycine, 5 parts of water, 30 parts of an anionic surfactant, 12 parts of a zwitterionic surfactant, 6 parts of a cationic polymer, 3 parts of a conditioner, 1 part of a preservative and 0.8 part of a essence in parts by weight. The nanometer anti-falling composition consists of 10 wt% of nanometer diaminopyrimidine oxide, 4 wt% of nanometer pyrrolidinyl diaminopyrimidine oxide, 6 wt% of polyglycerol-10 diisostearate and the balance of glycerol, propylene glycol and ethanol (equal to the weight of the three components); the anionic surfactant is sodium cocoyl glutamate and sodium laureth sulfate which are equal in weight; the zwitterionic surfactant is cocamidopropyl betaine; the cationic polymer is polyquaternium-10; the conditioner is jojoba oil.
The preparation method of the shampoo comprises the following steps:
(1) adding water into the main mixing tank at normal temperature, adding the zwitterionic surfactant, and uniformly stirring;
(2) adding a cationic polymer, uniformly stirring, heating to 90 ℃;
(3) adding anionic surfactant, keeping the temperature at 90 ℃, and stirring until the anionic surfactant is completely dissolved;
(4) cooling to below 50 deg.C, adding stearyl glucoside, and stirring;
(5) adding a conditioner, stirring uniformly, adding the nano composition, stirring uniformly, and adding the rest raw materials.
Example 6: the embodiment provides an anti-hair loss shampoo containing a nano composition, which comprises 16 parts of the nano anti-hair loss composition, 1 part of decyl glucoside, 0.5 part of caprylyl glycine, 5 parts of water, 30 parts of an anionic surfactant, 35 parts of a zwitterionic surfactant, 6 parts of a cationic polymer, 3 parts of a conditioner, 1 part of a preservative and 0.8 part of a essence in parts by weight. The nanometer anti-falling composition consists of 10 wt% of nanometer diaminopyrimidine oxide, 4 wt% of nanometer pyrrolidinyl diaminopyrimidine oxide, 6 wt% of polyglycerol-10 diisostearate and the balance of glycerol, propylene glycol and ethanol (equal to the weight of the three components); the anionic surfactant is sodium cocoyl glutamate and sodium laureth sulfate which are equal in weight; the zwitterionic surfactant is cocamidopropyl betaine; the cationic polymer is polyquaternium-10; the conditioner is jojoba oil.
The preparation method of the shampoo comprises the following steps:
(1) adding water into the main mixing tank at normal temperature, adding the zwitterionic surfactant, and uniformly stirring;
(2) adding a cationic polymer, uniformly stirring, heating to 90 ℃;
(3) adding anionic surfactant, keeping the temperature at 90 ℃, and stirring until the anionic surfactant is completely dissolved;
(4) cooling to below 50 deg.C, adding decyl glucoside, and stirring;
(5) adding a conditioner, stirring uniformly, adding the nano composition, stirring uniformly, and adding the rest raw materials.
Example 7: the embodiment provides an anti-hair loss shampoo containing a nano composition, which comprises 16 parts of the nano anti-hair loss composition, 1 part of decyl glucoside, 0.5 part of caprylyl glycine, 5 parts of water, 30 parts of an anionic surfactant, 12 parts of a zwitterionic surfactant, 6 parts of a cationic polymer, 3 parts of a conditioner, 1 part of a preservative and 0.8 part of a essence in parts by weight. The nanometer anti-falling composition consists of 10 wt% of nanometer diaminopyrimidine oxide, 4 wt% of nanometer pyrrolidinyl diaminopyrimidine oxide, 6 wt% of polyglycerol-10 diisostearate and the balance of glycerol, propylene glycol and ethanol (equal to the weight of the three components); the anionic surfactant is sodium dodecyl benzene sulfonate; the zwitterionic surfactant is cocamidopropyl betaine; the cationic polymer is polyquaternium-10; the conditioner is jojoba oil.
The preparation method of the shampoo comprises the following steps:
(1) adding water into the main mixing tank at normal temperature, adding the zwitterionic surfactant, and uniformly stirring;
(2) adding a cationic polymer, uniformly stirring, heating to 90 ℃;
(3) adding anionic surfactant, keeping the temperature at 90 ℃, and stirring until the anionic surfactant is completely dissolved;
(4) cooling to below 50 deg.C, adding decyl glucoside, and stirring;
(5) adding a conditioner, stirring uniformly, adding the nano composition, stirring uniformly, and adding the rest raw materials.
Example 8: the embodiment provides an anti-hair loss shampoo containing a nano composition, which comprises 16 parts of the nano anti-hair loss composition, 1 part of decyl glucoside, 0.5 part of caprylyl glycine, 5 parts of water, 30 parts of an anionic surfactant, 12 parts of a zwitterionic surfactant, 6 parts of a cationic polymer, 3 parts of a conditioner, 1 part of a preservative and 0.8 part of a essence in parts by weight. The nanometer anticreep composition consists of nanometer diaminopyrimidine oxide in 10 wt% and nanometer pyridine in 4 wt%Alloalkyl diamino pyrimidine oxide, 5 wt% of glycerol monocaprylate, and the balance of glycerol, propylene glycol and ethanol (equal weight of the three); the anionic surfactant is sodium cocoyl glutamate and sodium laureth sulfate which are equal in weight; the zwitterionic surfactant is cocamidopropyl betaine; the cationic polymer is polyquaternium-10; the conditioner is jojoba oil.
The preparation method of the shampoo comprises the following steps:
(1) adding water into the main mixing tank at normal temperature, adding the zwitterionic surfactant, and uniformly stirring;
(2) adding a cationic polymer, uniformly stirring, heating to 90 ℃;
(3) adding anionic surfactant, keeping the temperature at 90 ℃, and stirring until the anionic surfactant is completely dissolved;
(4) cooling to below 50 deg.C, adding decyl glucoside, and stirring;
(5) adding a conditioner, stirring uniformly, adding the nano composition, stirring uniformly, and adding the rest raw materials.
Example 9: the embodiment provides an anti-hair loss shampoo containing a nano composition, which comprises 16 parts of the nano anti-hair loss composition, 1 part of decyl glucoside, 0.5 part of caprylyl glycine, 5 parts of water, 30 parts of an anionic surfactant, 12 parts of a zwitterionic surfactant, 6 parts of a cationic polymer, 3 parts of a conditioner, 1 part of a preservative and 0.8 part of a essence in parts by weight. The nanometer anti-falling composition consists of 10 wt% of nanometer diaminopyrimidine oxide, 4 wt% of nanometer pyrrolidinyl diaminopyrimidine oxide and the balance of glycerol, propylene glycol and ethanol (the weight of the three is equal); the anionic surfactant is sodium cocoyl glutamate and sodium laureth sulfate which are equal in weight; the zwitterionic surfactant is cocamidopropyl betaine; the cationic polymer is polyquaternium-10; the conditioner is jojoba oil.
The preparation method of the shampoo comprises the following steps:
(1) adding water into the main mixing tank at normal temperature, adding the zwitterionic surfactant, and uniformly stirring;
(2) adding a cationic polymer, uniformly stirring, heating to 90 ℃;
(3) adding anionic surfactant, keeping the temperature at 90 ℃, and stirring until the anionic surfactant is completely dissolved;
(4) cooling to below 50 deg.C, adding decyl glucoside, and stirring;
(5) adding a conditioner, stirring uniformly, adding the nano composition, stirring uniformly, and adding the rest raw materials.
The applicant provided 80 male subjects suffering from alopecia to use the hair loss prevention shampoo containing the nano composition in the above examples, one group of every 10 persons, and used the samples in the above examples. The using method comprises the steps of taking about 6-8 g of the anti-hair loss shampoo containing the nano composition, washing hair by a normal method, washing hair once every three days, continuously using for 8 weeks, and washing hair 19 times in a cumulative mode. The evaluation criteria of the curative effect are as follows: 1) the effect is shown: the hair loss is obviously sensed within 5 times when the shampoo is used; 2) the method has the following advantages: after the hair washing liquid is used for 5-10 times, hair loss is reduced when hair washing is sensed; 3) micro-effect: after 8 weeks of use, hair loss is reduced when hair is washed; 4) and (4) invalidation: the symptoms of alopecia did not improve, and the results are shown in table 2 below.
TABLE 2
| Show effect | Is effective | Micro-effect | Invalidation | Display efficiency | |
| Example 1 | 9 | 1 | 0 | 0 | 90％ |
| Example 2 | 6 | 3 | 1 | 0 | 60％ |
| Example 3 | 6 | 4 | 0 | 0 | 60％ |
| Example 4 | 8 | 2 | 0 | 0 | 80％ |
| Example 5 | 7 | 3 | 0 | 0 | 70％ |
| Example 6 | 8 | 2 | 0 | 0 | 80％ |
| Example 7 | 8 | 2 | 0 | 0 | 80％ |
| Example 8 | 7 | 3 | 0 | 0 | 70％ |
| Example 9 | 6 | 2 | 2 | 0 | 60％ |
Meanwhile, according to the severity scores of the discomfort conditions such as irritation, allergy and the like in the using process of the subjects, the scores are 1-10, wherein 1 is the occurrence of severe irritation and discomfort, and 10 is the absence of discomfort, and the average value of each sample is taken. The results are shown in Table 3 below.
TABLE 3
From the experimental results, the shampoo disclosed by the invention can enable the nanometer anti-hair-loss composition to effectively permeate into the scalp and hair follicles under the synergistic action of a plurality of components, so that the effect of the nanometer anti-hair-loss composition is exerted to the maximum extent, and meanwhile, the shampoo brings excellent experience for users.
In addition, the applicant evaluated the oil control effect of the shampoo in example 1, wherein the shampoo in example 1 was shampoo a, and the control experiment sample (shampoo B) was shampoo not containing the nano hair loss prevention composition, decyl glucoside and caprylyl glycine. The specific evaluation method comprises the following steps: and selecting 32 consumers (16 males and 16 females) to evaluate the oil control effect, and using the shampoo A and the shampoo B respectively by the consumers to perform half-head cleaning by a professional salon chef and then blow-drying. The oil on the scalp on the left and right sides was evaluated by the consumer after 24 hours. The result shows that 25 of 32 consumers consider that the oil control effect of the shampoo A is obviously higher than that of the shampoo B, 7 consider that the difference of the oil control effect is not large, and see that the oil control effect of the shampoo A is obviously higher than that of the shampoo B, namely, the caprylyl glycine has an excellent oil control effect. In addition, the applicant performed a foaming test on the shampoo and the control experimental sample in the above example 1. The specific test method comprises the following steps: add 4 grams of shampoo and 76 grams of water to the electric foam machine, open the foam machine and stir for one minute. As shown in FIG. 1, the amount of foam of shampoo A was 470ml, which is much higher than the amount of foam of shampoo B, which is 350 ml. The foam amount of the shampoo added with the three active ingredients is obviously improved, namely decyl glucoside can help the shampoo in the application to have good foaming performance.
The above description is only a preferred embodiment of the present invention, and is not intended to limit the present invention in other forms, and any person skilled in the art may modify or change the technical content disclosed above into an equivalent embodiment with equivalent changes, but all those simple modifications, equivalent changes and modifications made on the above embodiment according to the technical spirit of the present invention still belong to the protection scope of the present invention.
Claims (10)
1. The anti-hair loss shampoo containing the nano composition is characterized in that the preparation raw materials comprise, by weight, 0.0001-20 parts of the nano anti-hair loss composition, 0.1-30 parts of decyl glucoside, 0.001-10 parts of caprylyl glycine, 5-90 parts of water, 1-50 parts of an anionic surfactant, 1-30 parts of a zwitterionic surfactant and 0.01-10 parts of a cationic polymer.
2. The hair loss prevention shampoo containing the nano composition as claimed in claim 1, wherein the preparation raw materials further comprise 0.1-20 parts of a conditioning agent and/or 0.01-10 parts of a preservative and/or 0.01-10 parts of a essence.
3. The anti-hair loss shampoo containing the nano composition as claimed in claim 1, wherein the weight ratio of decyl glucoside to caprylyl glycine is (1-3): 1.
4. the nano-composition-containing anti-hair-loss shampoo as claimed in claim 1, wherein the weight ratio of decyl glucoside to caprylyl glycine is 2: 1.
5. the anti-hair loss shampoo containing nano-composition according to claim 1, wherein the nano-anti-hair loss composition comprises nano-scale diaminopyrimidine oxide and nano-scale pyrrolidinyl diaminopyrimidine oxide.
6. The alopecia prevention shampoo containing the nano-composition as defined in claim 5, wherein the nano-alopecia prevention composition further comprises a glycerin fatty acid ester.
7. The anti-hair loss shampoo containing the nano composition as claimed in claim 6, wherein the glycerin fatty acid ester is polyglyceryl distearate.
8. The alopecia prevention shampoo containing the nano-composition as defined in claim 5, wherein the nano-alopecia prevention composition further comprises 0.1-30 wt% of a polyol.
9. The anti-hair loss shampoo containing the nano composition as claimed in any one of claims 1 to 8, wherein the weight ratio of the anionic surfactant to the zwitterionic surfactant is (2-3): 1.
10. the preparation method of the hair loss prevention shampoo containing the nano composition according to any one of claims 2 to 9, characterized by comprising the following steps:
(1) adding water into the main mixing tank at normal temperature, adding the zwitterionic surfactant, and uniformly stirring;
(2) adding a cationic polymer, uniformly stirring, heating to 80-90 ℃;
(3) adding anionic surfactant, keeping the temperature at 80-90 deg.C, and stirring until completely dissolved;
(4) cooling to below 50 deg.C, adding decyl glucoside, and stirring;
(5) adding a conditioner, stirring uniformly, adding the nano composition, stirring uniformly, and adding the rest raw materials.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN116172888A (en) * | 2022-12-21 | 2023-05-30 | 陕西畅想制药有限公司 | Composition containing amino acid derivatives for regulating skin microecology |
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Application publication date: 20210326 |