CN112543639A - 用于递送mrna和长核酸的脂质纳米颗粒组合物 - Google Patents

用于递送mrna和长核酸的脂质纳米颗粒组合物 Download PDF

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CN112543639A
CN112543639A CN201980050099.7A CN201980050099A CN112543639A CN 112543639 A CN112543639 A CN 112543639A CN 201980050099 A CN201980050099 A CN 201980050099A CN 112543639 A CN112543639 A CN 112543639A
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D·J·西格沃特
程强
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University of Texas System
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CN201980050099.7A 2018-06-19 2019-06-19 用于递送mrna和长核酸的脂质纳米颗粒组合物 Pending CN112543639A (zh)

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US201862687010P 2018-06-19 2018-06-19
US62/687010 2018-06-19
PCT/US2019/037904 WO2019246203A1 (en) 2018-06-19 2019-06-19 Lipid nanoparticle compositions for delivery of mrna and long nucleic acids

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EP (1) EP3810148A4 (https=)
JP (2) JP2021528426A (https=)
CN (1) CN112543639A (https=)
AU (2) AU2019288373B2 (https=)
CA (1) CA3103528A1 (https=)
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Cited By (5)

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CN113637708A (zh) * 2021-08-09 2021-11-12 中国科学院过程工程研究所 一种CRISPR-cas9基因编辑系统递送载体及其制备方法和应用
CN116271105A (zh) * 2023-05-18 2023-06-23 上海贝斯昂科生物科技有限公司 一种适于rpe细胞转染的脂质纳米颗粒及其应用
CN117177954A (zh) * 2021-04-13 2023-12-05 成都威斯津生物医药科技有限公司 用于核酸递送的可离子化脂质及其组合物
WO2024138370A1 (zh) * 2022-12-27 2024-07-04 北京炫景瑞医药科技有限公司 一种治疗高尿酸相关疾病的核酸药物及其制备方法和用途
WO2024183821A1 (zh) * 2023-03-09 2024-09-12 上海吉量医药工程有限公司 可离子化脂质分子及其制备方法和应用

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KR20200033259A (ko) 2017-07-31 2020-03-27 리제너론 파마슈티칼스 인코포레이티드 생체내에서 CRISPR/Cas-매개된 파괴 또는 삭제 및 외인성 도너 핵산과의 CRISPR/Cas-유도된 재조합을 평가하기 위한 방법 및 조성물
CN110891420B (zh) 2017-07-31 2022-06-03 瑞泽恩制药公司 Cas转基因小鼠胚胎干细胞和小鼠及其应用
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Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN117177954A (zh) * 2021-04-13 2023-12-05 成都威斯津生物医药科技有限公司 用于核酸递送的可离子化脂质及其组合物
CN117177954B (zh) * 2021-04-13 2024-06-04 成都威斯津生物医药科技有限公司 用于核酸递送的可离子化脂质及其组合物
CN113637708A (zh) * 2021-08-09 2021-11-12 中国科学院过程工程研究所 一种CRISPR-cas9基因编辑系统递送载体及其制备方法和应用
WO2024138370A1 (zh) * 2022-12-27 2024-07-04 北京炫景瑞医药科技有限公司 一种治疗高尿酸相关疾病的核酸药物及其制备方法和用途
WO2024183821A1 (zh) * 2023-03-09 2024-09-12 上海吉量医药工程有限公司 可离子化脂质分子及其制备方法和应用
CN116271105A (zh) * 2023-05-18 2023-06-23 上海贝斯昂科生物科技有限公司 一种适于rpe细胞转染的脂质纳米颗粒及其应用
CN116271105B (zh) * 2023-05-18 2023-08-25 上海贝斯昂科生物科技有限公司 一种适于rpe细胞转染的脂质纳米颗粒及其应用

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WO2019246203A1 (en) 2019-12-26
AU2019288373B2 (en) 2025-05-29
US20210121411A1 (en) 2021-04-29
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EP3810148A4 (en) 2022-06-08
GB202100678D0 (en) 2021-03-03
GB202107391D0 (en) 2021-07-07
EP3810148A1 (en) 2021-04-28
CA3103528A1 (en) 2019-12-26
AU2019288373A1 (en) 2021-01-14
AU2025220887A1 (en) 2025-09-18
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