CN112514910A

CN112514910A - Insecticidal composition containing sulfoxaflor and bistrifluron

Info

Publication number: CN112514910A
Application number: CN201910873308.XA
Authority: CN
Inventors: 葛家成; 张永芳; 董德臻; 吕文东
Original assignee: Qingdao Audis Biological And Technology Co ltd
Current assignee: Qingdao Audis Biological And Technology Co ltd
Priority date: 2019-09-17
Filing date: 2019-09-17
Publication date: 2021-03-19
Anticipated expiration: 2039-09-17
Also published as: CN112514910B

Abstract

The invention discloses an insecticidal composition containing sulfoxaflor and bistrifluron. The composition comprises an active ingredient A and an active ingredient B, wherein the active ingredient A is sulfoxaflor, and the active ingredient B is bistrifluron. The mass ratio of the active ingredient A to the active ingredient B in the composition is 1: 80-80: 1, the total weight of the active ingredients accounts for 1% -80% of the composition, and the composition has a remarkable synergistic effect and is beneficial to overcoming and delaying the drug resistance of pests. The composition can effectively control common lepidoptera, homoptera and thysanoptera pests of crops, and particularly can be used for controlling rice planthoppers and trialeurodes vaporariorum, and the effect of the composition is obviously higher than that of a single agent of the composition.

Description

Insecticidal composition containing sulfoxaflor and bistrifluron

Technical Field

The invention relates to an insecticidal composition, in particular to an insecticidal composition containing sulfoxaflor and bistrifluron and application thereof in preventing and treating crop pests, and belongs to the field of pesticide.

Background

With the change of planting structures and agricultural production modes in China, a large amount of pesticides are frequently applied, so that the resistance of pests to pesticides rises faster and faster, and resistant pests such as whiteflies, planthoppers, diamond back moths and the like are more and more serious in recent years, thereby causing great loss to agricultural production. The search for pesticides or pesticide compositions which have good control effect on resistant pests and can delay the resistance of the pests is one of the research and development subjects of pesticide manufacturers.

Sulfoxaflor (Sulfoxaflo)r) is a neonicotinoid insecticide with the chemical name: [ methyl { -1- [6- (trifluoromethyl) -3-pyridinyl group]Ethyl } -lambda⁶-sulfoxide]Cyanoimine, CAS number 946578-00-3. The sulfoxaflor acts on the nervous system of insects, exerts the insecticidal function by activating the unique binding site in the saline-alkali type phthalein choline receptor, can enter the plant body by being absorbed by leaves, stems and roots, and can effectively prevent and control piercing-sucking pests.

Bistrifluron (Bistrifluron) is a benzoylurea insecticide, and the chemical name of the Bistrifluron is as follows: 1- [ 2-chloro-3, 5-bis (trifluoromethyl) phenyl ] -3- (2, 6-difluorobenzoyl) urea with CAS number 201593-84-2. The bistrifluron is a chitin synthesis inhibitor, can obviously inhibit the production and development of insects, and enables the insects to die because of abnormal molting; can be used for preventing and controlling homoptera, lepidoptera, coleoptera and other pests.

At present, in the use of pesticides, active ingredients with different action mechanisms are compounded, so that the method is an effective method for delaying the resistance of pests. The compounded product can effectively improve the control effect and reduce the use amount of pesticide, thereby greatly delaying the generation of drug resistance of pests and being an important means for comprehensively controlling the pests. The prior art does not disclose the combination report of sulfoxaflor and bistrifluron.

Disclosure of Invention

The invention aims to provide an insecticidal composition containing sulfoxaflor and bistrifluron, which can be used for controlling crop pests, can effectively reduce the application dosage of active ingredients, reduce environmental pollution and delay the generation of drug resistance of the pests.

The technical scheme of the invention is as follows:

an insecticidal composition containing sulfoxaflor and bistrifluron comprises an active ingredient A and an active ingredient B, wherein the active ingredient A is sulfoxaflor, and the active ingredient B is bistrifluron.

The weight ratio of the active ingredient A to the active ingredient B of the insecticidal composition is 1: 80-80: 1;

further, the weight ratio of the active ingredient A to the active ingredient B is 1: 20-20: 1;

further, the mass ratio of the active ingredient A to the active ingredient B is 1: 10-5: 1;

further, the mass ratio of the active ingredient A to the active ingredient B is 1: 3-2: 1;

further, the mass ratio of the active ingredient A to the active ingredient B is 1:3, 1:2, 1:1 and 2: 1;

further, the mass ratio of the active ingredient A to the active ingredient B is preferably 1:2

The weight sum of the active ingredients in the insecticidal composition is 1-80%, preferably 10-50% of the composition.

The insecticidal composition can be prepared into agriculturally acceptable preparations together with pesticide auxiliary components;

further, the auxiliary components of the pesticide preparation comprise a carrier and an auxiliary agent;

further, the carrier is any one, two or three of water, a solvent or a filler, and the water is preferably deionized water;

further, the solvent is selected from one or a mixture of more of N, N-dimethylformamide, cyclohexanone, toluene, xylene, dimethyl sulfoxide, methanol, ethanol, trimethylcyclohexanone, N-octylpyrrolidone, ethanolamine, triethanolamine, isopropylamine, N-methylpyrrolidone, propanol, butanol, ethylene glycol, diethylene glycol, ethylene glycol methyl ether, butyl ether, ethanolamine, isopropylamine, ethyl acetate or acetonitrile;

further, the filler is selected from one or a mixture of more of kaolin, diatomite, bentonite, attapulgite, white carbon black, starch or light calcium carbonate;

furthermore, the auxiliary agent at least comprises a surfactant, and other functional auxiliary agents such as an antifreezing agent, a thickening agent, a stabilizing agent, a disintegrating agent, a defoaming agent and the like can be added according to different use occasions and requirements;

further, the surfactant is selected from one or more of an emulsifier, a dispersant, a wetting agent or a penetrant;

further, the other functional auxiliary agents are selected from one or more of an antifreezing agent, a thickening agent, a stabilizing agent, a disintegrating agent or an antifoaming agent;

further, the emulsifier is selected from one or more of agricultural milk 500# (calcium alkyl benzene sulfonate), OP series phosphate ester (nonylphenol polyoxyethylene ether phosphate ester), 600# phosphate ester (phenylphenol polyoxyethylene ether phosphate ester), styrene polyoxyethylene ether ammonium sulfate salt, magnesium salt of alkyl diphenyl ether disulfonate, triethanolamine salt, agricultural milk 400# (benzyldimethylphenol polyoxyethylene ether), agricultural milk 700# (alkylphenol formaldehyde resin polyoxyethylene ether), Ningru 36# (phenethylphenol formaldehyde resin polyoxyethylene ether), agricultural milk 1600# (phenethylphenol polyoxyethylene polyoxypropylene ether), ethylene oxide-propylene oxide block copolymer, OP series (nonylphenol polyoxyethylene ether), BY series (castor oil polyoxyethylene ether), agricultural dehydrated milk 33# (alkylaryl polyoxyethylene polyoxypropylene ether), span series (sorbitan monostearate), Tween series (sorbitan fatty acid ester polyoxyethylene ether) or AEO series (fatty alcohol polyoxyethylene ether) A mixture of seed constituents;

further, the dispersing agent is selected from one or a mixture of a plurality of polycarboxylate, lignosulfonate, alkylphenol polyoxyethylene formaldehyde condensate sulfate, calcium alkylbenzene sulfonate, sodium salt of naphthalene sulfonic acid formaldehyde polymer, alkylphenol polyoxyethylene, fatty amine polyoxyethylene, fatty acid polyoxyethylene or glycerol fatty acid ester polyoxyethylene;

further, the wetting agent is selected from one or a mixture of more of sodium dodecyl sulfate, sodium dodecyl benzene sulfonate, nekal BX, wetting penetrant F, Chinese honeylocust fruit powder, silkworm excrement or soapberry powder;

further, the penetrating agent is selected from a mixture consisting of one or more of penetrating agent JFC (fatty alcohol-polyoxyethylene ether), penetrating agent T (diisooctyl maleate sulfonate), azone or organic silicon;

further, the antifreezing agent is a mixture consisting of one or more of ethylene glycol, propylene glycol, glycerol or urea;

further, the thickening agent is selected from one or more of xanthan gum, polyvinyl alcohol, bentonite, carboxymethyl cellulose or magnesium aluminum silicate;

further, the stabilizer is selected from one or more of epoxidized soybean oil, epichlorohydrin, BHT, ethyl acetate and triphenyl phosphate;

further, the disintegrating agent is selected from one or more of bentonite, urea, ammonium sulfate, aluminum chloride, low-substituted hydroxypropyl cellulose, lactose, citric acid, succinic acid or sodium bicarbonate;

further, the defoaming agent is selected from one or a mixture of more of silicone oil, silicone compounds, C10-C20 saturated fatty acid compounds or C8-C10 fatty alcohol compounds;

all of the above are commercially available.

The compositions of the present invention may be formulated into pesticidally acceptable dosage forms, including solid, liquid, seed treatment, other formulations, according to methods well known to those skilled in the art;

further, the solid preparation is powder, dispersible tablets, granules, soluble powder, soluble granules, soluble tablets, milk powder, milk granules, water dispersible granules, wettable powder, micro-capsule granules, powder, macro-granules and water dispersible tablets;

further, the liquid preparation is microcapsule suspending agent, dispersible agent, missible oil, emulsion granules, oil emulsion, emulsion powder, aqueous emulsion, microemulsion, dispersible oil suspending agent, oil dispersion powder, suspending agent, suspoemulsion, soluble solution and ultra-low volume liquid;

further, the seed treatment preparation is a suspended seed coating agent, a seed treatment dry powder agent, a seed treatment dispersible powder agent, a seed treatment suspending agent and a seed treatment liquid agent;

further, the other preparations are bait, concentrated bait, gas preparation, aerosol, smoke agent;

furthermore, the preparation formulation is preferably a suspending agent, wettable powder and water dispersible granules;

further, the composition is prepared into a suspending agent, and the components and the content of the suspending agent are preferably as follows: 0.1-80% of active ingredient A, 0.1-80% of active ingredient B, 2-10% of dispersing agent, 2-10% of wetting agent, 0.01-2% of defoaming agent, 0-2% of thickening agent, 0-8% of antifreeze agent and the balance of deionized water;

further, the composition is prepared into wettable powder, and the components and the content of the wettable powder are preferably as follows: 0.1-80% of active ingredient A, 0.1-80% of active ingredient B, 2-10% of dispersing agent, 2-10% of wetting agent and the balance of filler;

further, the composition is prepared into water dispersible granules, and the components and the content of the water dispersible granules are preferably as follows: 0.1-80% of active ingredient A, 0.1-80% of active ingredient B, 3-12% of dispersing agent, 1-8% of wetting agent, 1-10% of disintegrating agent and the balance of filler.

The insecticidal composition is used for preventing and controlling hemiptera, thysanoptera, lepidoptera and homoptera pests of crops.

Further, the pests are rice planthopper and trialeurodes vaporariorum.

Compared with the prior art, the invention has the following beneficial effects: the insecticidal composition provided by the invention can generate a higher synergistic effect, is high in insecticidal speed, overcomes and delays the drug resistance of pests, can expand an insecticidal spectrum and reduce the drug cost, and has an effect obviously superior to that of a single agent.

Detailed Description

The present invention will be described in more detail with reference to examples. The practice of the invention is not limited to the following examples, and any variations or modifications in practice of the invention are intended to fall within the scope of the invention. The methods in the following examples are conventional in the art unless otherwise specified.

Preparation of the preparation

Example 1: 20% sulfoxaflor-bistrifluron suspending agent (1:1)

The formula is as follows: 10% of sulfoxaflor, 10% of bistrifluron, 6% of sodium salt of naphthalene sulfonic acid formaldehyde polymer, 7% of sodium lauryl sulfate, 1% of silicone oil, 1% of sodium acrylate, 7% of glycerol and the balance of deionized water.

The preparation method comprises the following steps: according to the formula proportion, the active ingredients of sulfoxaflor, bistrifluron, a surfactant and other functional auxiliaries are sequentially placed in a reaction kettle, water is added for uniform mixing, and the product is obtained through high-speed shearing, wet sanding and finally homogeneous filtration.

Example 2: 10% sulfoxaflor-bistrifluron suspending agent (1:1)

The formula is as follows: 5% of sulfoxaflor, 5% of bistrifluron, 7% of polycarboxylate, 7% of saponin powder, 1% of silicone, 1% of sodium tripolyphosphate and the balance of deionized water.

The preparation method comprises the following steps: the same as in example 1.

Example 3: 30% sulfoxaflor-bistrifluron suspending agent (1:2)

The formula is as follows: 10% of sulfoxaflor, 20% of bistrifluron, 7% of polycarboxylate, 1% of sodium acrylate, 7% of glycerol and the balance of deionized water.

The preparation method comprises the following steps: the same as in example 1.

Example 4: 20% sulfoxaflor-bistrifluron wettable powder (1:1)

The formula is as follows: 10% of sulfoxaflor, 10% of bistrifluron, 5% of polyoxyethylene octylphenol ether, 6% of sodium dodecyl benzene sulfonate and the balance of white carbon black.

The preparation method comprises the following steps: according to the formula proportion of the embodiment, the active ingredients of sulfoxaflor and bistrifluron are added into a carrier, and a surfactant and other functional additives are added into the carrier, mixed, subjected to air flow crushing and mixed to prepare the wettable powder.

Example 5: 22% sulfoxaflor-bistrifluron wettable powder (1:10)

The formula is as follows: 20% of sulfoxaflor, 2% of bistrifluron, 3% of lignosulfonate, BX 7% of nekal and the balance of kaolin.

The preparation method comprises the following steps: the same as in example 4.

Example 6: 5% sulfoxaflor-bistrifluron wettable powder (1:4)

The formula is as follows: 1% of sulfoxaflor, 4% of bistrifluron, 2% of polyoxyethylene octylphenol ether, 1% of sodium dodecyl benzene sulfonate and the balance of white carbon black.

The preparation method comprises the following steps: the same as in example 4.

Example 7: 30% sulfoxaflor-bistrifluron water dispersible granule (2:1)

The formula is as follows: 20% of sulfoxaflor, 10% of bistrifluron, 4% of lignosulfonate, 3% of sodium dodecyl benzene sulfonate, 5% of aluminum chloride and the balance of white carbon black.

The preparation method comprises the following steps: adding active ingredients, namely sulfoxaflor and bistrifluron, into a carrier according to the formula proportion of an embodiment, adding a surfactant and other functional auxiliaries, mixing, performing jet milling, adding 10-25% of water, kneading, granulating, drying and screening to obtain a water dispersible granule product; or spraying water to the pulverized powder in a boiling granulator, granulating, drying, and sieving to obtain the water dispersible granule.

Example 8: 15% sulfoxaflor-bistrifluron water dispersible granule (1:2)

The formula is as follows: 5% of sulfoxaflor, 10% of bistrifluron, 5% of naphthalenesulfonic acid formaldehyde polymer sodium salt, 5% of nekal BX 5%, 3% of bentonite and the balance of kaolin.

The preparation method comprises the following steps: the same as in example 7.

Example 9: 20% sulfoxaflor-bistrifluron water dispersible granule (1:3)

The formula is as follows: 5% of sulfoxaflor, 15% of bistrifluron, 4% of lignosulfonate, BX 5% of nekal, 3% of bentonite and the balance of white carbon black.

The preparation method comprises the following steps: the same as in example 7.

Indoor activity

Example 10: combined toxicity of sulfoxaflor and bistrifluron to greenhouse cucumber whitefly

The test basis is as follows: the test was carried out according to NY/T1154.9-2008 "indoor pesticide bioassay Standard part 9 spraying method". The embodiment of the invention adopts a method combining indoor toxicity measurement and field test. Firstly, determining the co-toxicity coefficient (CTC) of two medicaments compounded according to a certain proportion by indoor toxicity measurement, wherein the CTC is less than 80 and is antagonistic, the CTC is more than 120 and is synergistic, and the CTC is added between 80 and 120, and then carrying out field test on the basis.

The tested pests: cucumber whitefly (Trialeurodes vaporariorum) collected from the greenhouse of the wind shift shop in Shandong, Jimo.

Test agents: 95% sulfoxaflor and 95% bistrifluron, both provided by the Heliel pharmaceutical industry group, Inc.

Preparing a medicament: the original drug is respectively dissolved by DMF, 10000mg/L mother liquor is respectively prepared, on the basis of pre-test, the mother liquor is diluted by 0.1% Tween 80 aqueous solution, and 5 different concentrations are set for each treatment for standby.

The test was repeated: 20 2-instar nymphs were treated at each concentration and divided into 4 replicates, with an aqueous solution containing 0.1% tween 80 as a control. Treating by spraying.

Medicament treatment: according to test criteria, 2-year nymphs which are regularly and consistently grown are selected by a writing brush and placed in a culture dish, the culture dish is placed on a spraying tower chassis for quantitative spraying, the spraying liquid amount is 1ml, the test insects are taken out after the liquid medicine is settled for 5min, and the treated test insects are placed under appropriate conditions for feeding. 20 nymphs were kept for each treatment, and each treatment was repeated 4 times, 48 hours after treatment, and the number of dead insects on each leaf was checked.

Data statistics and analysis: the blank control mortality rate is less than 5% without correction; the blank control mortality rate is 5% -10%, and the mortality rate needs to be corrected; if the blank control rate is more than 10%, the experiment needs to be carried out again.

The calculation formula is as follows:

by LC₅₀The relatively small-value agent is a standard agent, and the virulence index TI thereof is 100.

Theoretical toxicity index TI of mixed preparation_A×P_A+TI_B×P_B

In the formula: p_A、P_BRespectively the proportion of the active component A, B in the composition.

The test results are shown in table 1:

TABLE 1 combination virulence results of sulfoxaflor and bistrifluron in combination for greenhouse cucumber whitefly

Indoor activity tests show that (shown in table 1), the sulfoxaflor and bistrifluron are mixed to have good indoor activity on greenhouse cucumber whiteflies, and when the mixing ratio of the sulfoxaflor and bistrifluron is 1: 10-5: 1, the co-toxicity coefficients are all larger than 120, so that a synergistic effect is shown; the co-toxicity coefficients of the sulfoxaflor and the bistrifluron are all more than 150 when the mixing ratio of the sulfoxaflor to the bistrifluron is 1: 3-2: 1, and the effect is obvious synergistic; the maximum co-toxicity coefficient of the sulfoxaflor and the bistrifluron is 185.89 when the mixing ratio is 1:2, and the synergistic effect is most obvious.

Test of field drug effect

Example 11: to verify sulfoxaflor and bistrifluoromethaneThe inventor carries out a field efficacy test on the field efficacy of the insect urea on the rice planthopper in 7 months in 2018 at the Helier test base of Qingdao Shifeng shop. When the pesticide is applied, the rice is in a vigorous growth stage, the growth is uniform, the growth amount of the rice planthopper is large, and the rice planthopper is mainly young. The test sets 8 treatments, and the dosage of each treatment is 50g/hm of the effective component²Blank control (see table 2) is set, random block arrangement is adopted, the area of a cell is 20 square, each treatment is repeated for 4 times, the population base number is investigated before the medicine, and the investigation is respectively carried out for 1 time after 1 day, 3 days and 7 days, and the investigation is carried out for 4 times in total. Randomly marking 5 points per cell, investigating 5 clusters per point, investigating the number of live insects on each cluster, calculating the number of live insects, calculating the reduction rate of population and preventing and treating effect.

Percent reduction rate (%) of population (number of population before treatment-number of population after treatment) × 100/number of population before treatment

Control effect (%) (treatment area population reduction rate-control area population reduction rate)' 100/(1-control area population reduction rate)

TABLE 2 field control Effect of sulfoxaflor and bistrifluron Mixed paired rice planthoppers

Test agent	1 day after administration	Control effect 3 days after drug administration	The control effect is 7 days after the drug is taken
				10% sulfoxaflor-bistrifluron (1:1) suspending agent	50.0	83.3	93.3
20% sulfoxaflor-bistrifluron (1:1) wettable powder	48.0	89.3	96.7
				15% sulfoxaflor-bistrifluron (1:2) water dispersible granule	60.3	94.1	98.5
30% sulfoxaflor-bistrifluron (1:2) suspending agent	69.0	97.2	100.0
				20% sulfoxaflor-bistrifluron (3:1) wettable powder	56.3	89.2	95.6
30% sulfoxaflor and bistrifluron (2:1) water dispersible granule	55.6	87.1	96.0
				20% sulfoxaflor suspension	44.4	77.8	87.4
10% bistrifluron suspension	33.6	82.6	85.9

The field efficacy test shows that (see table 2) the mixture of the sulfoxaflor and the bistrifluron has good control effect on the rice planthopper in different proportions, and the control effect is better than that of a single agent in 1 day, 3 days and 7 days after the pesticide is applied. According to daily observation after the pesticide, rice in each treatment area grows well, and no phytotoxicity phenomenon is found.

Example 12: to verify the field efficacy of sulfoxaflor and bistrifluron against trialeurodes vaporariorum, the inventors carried out a field efficacy test in the haili test base of the Qingdao Shifengshi in 2018 in 6 months. When the pesticide is applied, the trialeurodes vaporariorum is serious at the test point, mainly larvae are used, 8 treatments are set in the test, and the dosage of each treatment as an effective component is 30g/hm²Random block arrangement is adopted, the population base number is investigated before application, and the population is investigated 1 time each for 1 day, 3 days and 7 days after application, and 4 times total investigation is carried out. Sampling 5 points in each cell, fixing 2 plants in each point, carefully checking the back of the leaf, investigating the head number of the trialeurodes vaporariorum on the fixed plant in the case that the adult insects do not move and do not frighten the insects in the morning, and calculating the reduction rate of the insect population and the control effect.

Control effect (%) (treatment area population reduction rate-control area population reduction rate)' 100/(100-control area population reduction rate)

TABLE 3 field control Effect of sulfoxaflor and bistrifluron mix-paired cucumber whitefly

The test results show (see table 3): the mixture of the sulfoxaflor and the bistrifluron has good control effect on cucumber whitefly, and has long lasting period, and the control effect is more than 95 percent in 7 days after the pesticide is applied. According to daily observation after the application, the cucumber in each treatment area grows well, and no phytotoxicity phenomenon is found.

Claims

1. The insecticidal composition containing sulfoxaflor and bistrifluron is characterized in that the effective components contain an active component A and an active component B, the active component A is sulfoxaflor, and the active component B is bistrifluron.

2. The insecticidal composition according to claim 1, wherein the mass ratio of the active ingredient A to the active ingredient B is 1: 80-80: 1.

3. The insecticidal composition according to claim 1, wherein the mass ratio of the active ingredient A to the active ingredient B is 1: 20-20: 1.

4. The insecticidal composition according to claim 1, wherein the mass ratio of the active ingredient A to the active ingredient B is 1:10 to 5: 1.

5. The insecticidal composition according to claim 1, wherein the mass ratio of the active ingredient A to the active ingredient B is 1:3 to 2: 1.

6. An insecticidal composition according to claim 1, wherein the sum of the active ingredients in the composition is from 1% to 80%, preferably from 10% to 50% by weight of the total composition.

7. The insecticidal composition according to claim 1, wherein the composition is formulated in an agriculturally acceptable formulation in combination with a pesticidal adjuvant.

8. The insecticidal composition of claim 7, wherein said composition can be prepared into any one of agriculturally acceptable formulation forms including powder, dispersible tablet, granule, soluble powder, soluble granule, soluble tablet, emulsion powder, emulsion granule, water dispersible granule, wettable powder, microcapsule granule, powder, macrogranule, water dispersible tablet, microcapsule suspension, dispersible solution, emulsifiable concentrate, emulsion granule, oil emulsion, emulsion powder, water emulsion, microemulsion, oil dispersible suspension, oil dispersible powder, suspension, suspoemulsion, soluble solution, ultra-low volume liquid, suspended seed coating, dry seed treatment powder, dispersible seed treatment powder, suspension treatment suspension, seed treatment liquid; the preferable preparation formulation is suspending agent, wettable powder and water dispersible granule.

9. Use of the pesticidal composition according to any one of claims 1 to 8 for controlling hemipteran, thysanoptera, lepidoptera, homopteran pests.

10. The pest of claim 9 being rice planthopper, trialeurodes vaporariorum.