CN112494430B - 药物组合物的制备方法及药物组合物 - Google Patents

药物组合物的制备方法及药物组合物 Download PDF

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CN112494430B
CN112494430B CN202010954970.0A CN202010954970A CN112494430B CN 112494430 B CN112494430 B CN 112494430B CN 202010954970 A CN202010954970 A CN 202010954970A CN 112494430 B CN112494430 B CN 112494430B
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cellulose
pharmaceutical composition
pharmaceutical
water
cnc
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CN112494430A (zh
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M·诺珀宁
黄翔
宋秋海
王玉珑
刘艳新
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UPM Kymmene Oy
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UPM Kymmene Oy
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5161—Polysaccharides, e.g. alginate, chitosan, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5192—Processes

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Nanotechnology (AREA)
  • Optics & Photonics (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN202010954970.0A 2019-09-13 2020-09-11 药物组合物的制备方法及药物组合物 Active CN112494430B (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP19397527.3 2019-09-13
EP19397527.3A EP3791864A1 (en) 2019-09-13 2019-09-13 Method for preparing pharmaceutical composition and pharmaceutical composition

Publications (2)

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CN112494430A CN112494430A (zh) 2021-03-16
CN112494430B true CN112494430B (zh) 2023-06-02

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US (1) US11723867B2 (https=)
EP (1) EP3791864A1 (https=)
JP (1) JP7640065B2 (https=)
KR (1) KR20210032280A (https=)
CN (1) CN112494430B (https=)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3791858A1 (en) 2019-09-13 2021-03-17 UPM-Kymmene Corporation Injectable pharmaceutical formulation
JP2021090882A (ja) * 2021-03-19 2021-06-17 株式会社三洋物産 遊技機
JP2021090883A (ja) * 2021-03-19 2021-06-17 株式会社三洋物産 遊技機
JP2021090879A (ja) * 2021-03-19 2021-06-17 株式会社三洋物産 遊技機
JP2021090881A (ja) * 2021-03-19 2021-06-17 株式会社三洋物産 遊技機
JP2021090884A (ja) * 2021-03-19 2021-06-17 株式会社三洋物産 遊技機
CN116764001B (zh) * 2023-06-29 2025-11-11 上海交通大学医学院附属第九人民医院 多孔碳基双载药纳米缓释材料及其子宫支架与应用
WO2025155702A1 (en) * 2024-01-19 2025-07-24 University Of Maine System Board Of Trustees Cellulose-based hydrogels as vaccine adjuvants
CN119528842B (zh) * 2024-10-25 2025-12-16 上海工程技术大学 一种通过氧化纳米纤维素调控药物晶型的方法及应用

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JP4308336B2 (ja) * 1997-03-14 2009-08-05 株式会社日本吸収体技術研究所 ミクロフィブリル状微細繊維構造体およびその製造方法
AU757605B2 (en) 1999-01-28 2003-02-27 Indevus Pharmaceuticals, Inc. Hydrogel compositions useful for the sustained release of macromolecules and methods of making same
FI20095638A0 (fi) 2009-06-09 2009-06-09 Valtion Teknillinen Hydrofobiineja aktiivisten aineiden dispergointiin
FI123988B (fi) 2010-10-27 2014-01-31 Upm Kymmene Corp Soluviljelymateriaali
FI130619B (en) * 2011-11-15 2023-12-15 Upm Kymmene Corp Matrix for sustained delivery of bioactive agents
BR112015014523A2 (pt) 2012-12-19 2017-07-11 Kashiv Pharma Llc nanossuspensão estabilizada, composição farmacêutica, e, método de tratamento de um paciente
FI126109B (en) 2013-02-22 2016-06-30 Upm Kymmene Corp Nanofibril polysaccharide for use in the control and prevention of constriction and scarring
CN103520739B (zh) 2013-10-22 2015-01-28 东北林业大学 一种纤维素纳米纤丝和吲哚美辛自组装复合体系的制备方法
FI126854B (en) * 2013-12-30 2017-06-30 Upm Kymmene Corp The membrane, its use and the method for making the membrane
JP6712875B2 (ja) 2016-03-04 2020-06-24 第一工業製薬株式会社 繊維芽細胞増殖促進剤
FI3922279T3 (fi) 2016-08-30 2025-02-04 Dana Farber Cancer Inst Inc Lääkkeenantokoostumuksia ja niiden käyttötapoja
EP3791858A1 (en) 2019-09-13 2021-03-17 UPM-Kymmene Corporation Injectable pharmaceutical formulation

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Publication number Publication date
CN112494430A (zh) 2021-03-16
EP3791864A1 (en) 2021-03-17
JP2021046392A (ja) 2021-03-25
JP7640065B2 (ja) 2025-03-05
US20210077403A1 (en) 2021-03-18
KR20210032280A (ko) 2021-03-24
US11723867B2 (en) 2023-08-15

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