CN112481125A - Viral vaccine strain extraction device and extraction method thereof - Google Patents

Viral vaccine strain extraction device and extraction method thereof Download PDF

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Publication number
CN112481125A
CN112481125A CN202011384061.4A CN202011384061A CN112481125A CN 112481125 A CN112481125 A CN 112481125A CN 202011384061 A CN202011384061 A CN 202011384061A CN 112481125 A CN112481125 A CN 112481125A
Authority
CN
China
Prior art keywords
incubator
pulley
fixedly connected
vaccine strain
box
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN202011384061.4A
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Chinese (zh)
Inventor
安有才
于海龙
秦奇
马亮亮
戴伟
杨靖
万杰
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AB&B Bio Tech Co Ltd JS
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AB&B Bio Tech Co Ltd JS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by AB&B Bio Tech Co Ltd JS filed Critical AB&B Bio Tech Co Ltd JS
Priority to CN202011384061.4A priority Critical patent/CN112481125A/en
Publication of CN112481125A publication Critical patent/CN112481125A/en
Pending legal-status Critical Current

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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00Constructional details, e.g. recesses, hinges
    • C12M23/48Holding appliances; Racks; Supports
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B66HOISTING; LIFTING; HAULING
    • B66FHOISTING, LIFTING, HAULING OR PUSHING, NOT OTHERWISE PROVIDED FOR, e.g. DEVICES WHICH APPLY A LIFTING OR PUSHING FORCE DIRECTLY TO THE SURFACE OF A LOAD
    • B66F7/00Lifting frames, e.g. for lifting vehicles; Platform lifts
    • B66F7/02Lifting frames, e.g. for lifting vehicles; Platform lifts with platforms suspended from ropes, cables, or chains or screws and movable along pillars
    • B66F7/025Lifting frames, e.g. for lifting vehicles; Platform lifts with platforms suspended from ropes, cables, or chains or screws and movable along pillars screw operated
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B66HOISTING; LIFTING; HAULING
    • B66FHOISTING, LIFTING, HAULING OR PUSHING, NOT OTHERWISE PROVIDED FOR, e.g. DEVICES WHICH APPLY A LIFTING OR PUSHING FORCE DIRECTLY TO THE SURFACE OF A LOAD
    • B66F7/00Lifting frames, e.g. for lifting vehicles; Platform lifts
    • B66F7/10Lifting frames, e.g. for lifting vehicles; Platform lifts with platforms supported directly by jacks
    • B66F7/12Lifting frames, e.g. for lifting vehicles; Platform lifts with platforms supported directly by jacks by mechanical jacks
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B66HOISTING; LIFTING; HAULING
    • B66FHOISTING, LIFTING, HAULING OR PUSHING, NOT OTHERWISE PROVIDED FOR, e.g. DEVICES WHICH APPLY A LIFTING OR PUSHING FORCE DIRECTLY TO THE SURFACE OF A LOAD
    • B66F7/00Lifting frames, e.g. for lifting vehicles; Platform lifts
    • B66F7/28Constructional details, e.g. end stops, pivoting supporting members, sliding runners adjustable to load dimensions
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/12Means for regulation, monitoring, measurement or control, e.g. flow regulation of temperature
    • C12M41/14Incubators; Climatic chambers

Abstract

The invention discloses a viral vaccine strain extraction device and an extraction method thereof, and relates to the technical field of strain extraction auxiliary equipment, comprising a constant temperature box and an incubator, wherein screw rods are symmetrically arranged on the left side and the right side in the constant temperature box, the upper side and the lower side of each screw rod are rotationally connected with the side wall of the constant temperature box, a cavity is arranged on the bottom wall in the constant temperature box, the lower part of each screw rod is rotationally connected with a belt, the belt is arranged in the cavity, one end, close to each other, of each nut is fixedly connected with a hydraulic cylinder, the hydraulic cylinder is connected with a telescopic rod, one end, far away from the hydraulic cylinder, of the telescopic rod is fixedly connected with a clamp, the nuts on the left side and the right side drive the incubator to move upwards, the hydraulic cylinders drive the upper left box door and the right box, realize the regulation of height, be convenient for get the incubator and put.

Description

Viral vaccine strain extraction device and extraction method thereof
Technical Field
The invention relates to the technical field of virus strain extraction auxiliary equipment, in particular to a virus vaccine virus strain extraction device and an extraction method thereof.
Background
The vaccine is a biological product which is prepared from various pathogenic microorganisms and is used for vaccination. Wherein the vaccine made with the bacteria or spirochetes is also called bacterin. The vaccine is divided into a live vaccine and a dead vaccine, and the strain refers to the virus which needs to be cultured when the virus is tested. Strains are viruses grown under laboratory conditions. It is the protoplast of the virus, the virus produced by the hyphal-producing strain, and similar to the cell strain.
Need use culture equipment in to viral vaccine strain extraction process, culture equipment usually need keep the constant temperature state, generally places culture equipment in the thermostated container, and some culture equipment are bulky, and it is difficult to access, is difficult to adjust.
Disclosure of Invention
The invention aims to provide a viral vaccine strain extraction device and an extraction method thereof, so as to solve the problems in the background technology.
In order to achieve the purpose, the invention provides the following technical scheme:
a viral vaccine strain extraction device comprises a constant temperature box and an incubator, wherein the incubator is arranged in the constant temperature box, screw rods are symmetrically arranged on the left side and the right side in the constant temperature box, the upper side and the lower side of each screw rod are rotationally connected with the side wall of the constant temperature box, a cavity is arranged on the bottom wall in the constant temperature box, the left side and the right side are rotationally connected with the lower side of each screw rod through a belt, the belt is arranged in the cavity, a fixed connecting handle extends from the tail end of the bottom of the screw rod on the left side, a nut is arranged on the surface of each screw rod, one end of each nut on the left side and the right side is close to each other is fixedly connected with a hydraulic cylinder, the hydraulic cylinders are connected with telescopic rods, one end of each telescopic rod far away from the hydraulic cylinders is fixedly connected with, the oven comprises an oven top wall, a constant temperature box and a door frame, wherein the oven top wall is provided with a first end and a second end, the first end and the second end are symmetrically connected with the upper surface of the oven top wall, the first end and the second end of the oven top wall are symmetrically connected with a first pulley, the second end and the third end of the oven top wall are symmetrically connected with a second pulley, the third pulley is arranged below the second pulley, the second pulley and the third pulley are fixedly connected with the lateral wall of the oven, a pull rope is fixedly connected with the upper part of the oven door.
As a further scheme of the invention: the incubator top sets up thermodetector, the left and right sides the chamber door lower surface all sets up the heating and warming lamp.
As a still further scheme of the invention: the left side wall and the right side wall in the constant temperature box are symmetrically provided with limiting grooves, the nut is fixedly connected with a limiting seat, and the limiting seat is connected with the limiting grooves in a sliding mode.
As a still further scheme of the invention: the incubator bottom wall upper surface left and right sides symmetry sets up the support, the left and right sides set up the guide arm between the support, guide arm left and right sides symmetry sets up damping spring, damping spring and damper seat fixed connection, damper seat and guide arm sliding connection, damper seat top swing joint shock attenuation pole, the one end swing joint supporting platform of damper seat is kept away from to the shock attenuation pole, the supporting platform upper surface is arranged in to the incubator.
As a still further scheme of the invention: and a cushion pad is arranged on the upper surface of the supporting platform.
As a still further scheme of the invention: the left and right sides anchor clamps inside wall surface all sets up anti-skidding line.
As a still further scheme of the invention: the utility model discloses a constant temperature cabinet, including thermostated container, incubator diapire, support base upper surface left and right sides symmetry and set up the support, incubator diapire lower surface left and right sides symmetry sets up the locker, locker left and right sides wall symmetry sets up the rack board, the left and right sides the one end that the support is close to each other is passed through connecting rod fixed connection gear, gear and actuating mechanism fixed connection, gear and rack board meshing.
An extraction method of a viral vaccine strain extraction device comprises the following steps:
s1, the hydraulic cylinder pushes the telescopic rods to drive the left and right clamps to move inwards at the same time, and the clamps are clamped below the convex parts;
s2, rotating a handle, wherein the handle drives a left screw and a right screw to rotate through a belt, the left nut and the right nut drive the incubator to move upwards, and the hydraulic cylinder drives the upper left box door and the upper right box door to rotate upwards through a pull rope in the process of moving upwards so as to open the box doors;
s3, the gear is rotated and is meshed with the rack plate to drive the storage cabinet and the thermostat above the storage cabinet to move up and down in the vertical direction, and therefore height adjustment is achieved.
Compared with the prior art, the invention has the beneficial effects that: the utility model provides a viral bacterin strain extraction element, the pneumatic cylinder promotes the telescopic link and drives left and right sides anchor clamps and move to the inboard simultaneously, anchor clamps card is in the bellying below, through turning handle, the handle passes through the belt and drives the left and right sides screw rod and rotate, the left and right sides the nut drives the incubator rebound, the pneumatic cylinder drives top left and right sides chamber door rebound through the stay cord at rebound's in-process, makes the chamber door open, the gear reciprocates in vertical direction through driving locker and top thermostated container with rack plate meshing, realizes the regulation of height, is convenient for get the incubator and puts.
Drawings
Fig. 1 is a schematic structural diagram of a viral vaccine strain extraction device and an extraction method thereof.
Fig. 2 is a schematic view of an extraction device and an extraction method of a viral vaccine strain, wherein the part A in fig. 1 is enlarged.
FIG. 3 is a schematic structural diagram of a clamp in a viral vaccine strain extraction device and an extraction method thereof.
In the figure: 1-a constant temperature box; 2-heating a warm lamp; 3-an incubator; 4-pulling a rope; 5-a box door; 6-a temperature detector; 7-a boss; 8-screw rod; 9-pulley one; 10-a strut; 11-pulley II; 12-a gear; 13-a limiting groove; 14-a nut; 15-a clamp; 16-a telescopic rod; 17-a limiting seat; 18-a cushion pad; 19-a support platform; 20-a shock-absorbing seat; 21-pulley III; 22-a cavity; 23-a belt; 24-a scaffold; 25-a locker; 26-a support base; 27-a support; 28-a guide rod; 29-a damping spring; 30-a shock-absorbing rod; 31-a rack plate; 32-hydraulic cylinder; 33-handle.
Detailed Description
The technical solution of the present invention will be described in further detail with reference to specific embodiments.
Example 1
Referring to fig. 1-2, a viral vaccine strain extraction device comprises an incubator 1 and an incubator 3, wherein the incubator 3 is installed in the incubator 1, in order to facilitate taking and placing of the incubator 3, screws 8 are symmetrically arranged on the left side and the right side in the incubator 1, the upper side and the lower side of each screw 8 are rotatably connected with the side wall of the incubator 1, a cavity 22 is arranged on the inner bottom wall of the incubator 1, the lower sides of the screws 8 on the left side and the right side are rotatably connected through a belt 23, the belt 23 is installed in the cavity 22, the bottom end of the screw 8 on the left side extends and is fixedly connected with a handle 33, a nut 14 is arranged on the surface of each screw 8, the nut 14 can vertically move along with the rotation of the screw 8, one end of the nut 14 on the left side and the right side, which is close to each other, is fixedly connected with a hydraulic cylinder 32, the hydraulic cylinder, the incubator 3 is characterized in that a plurality of protruding portions 7 are arranged on the surface of the outer side wall of the incubator 3 at equal intervals, two doors 5 are symmetrically arranged on the left side and the right side of the top wall of the incubator 1, the left side and the right side of the door 5 are rotatably connected with the side wall of the incubator 1, supporting rods 10 are symmetrically arranged on the left side and the right side of the top wall of the incubator 1, one end, away from the incubator 1, of each supporting rod 10 is connected with a pulley I9, two pulleys 11 are symmetrically and transversely arranged on the left side and the right side of the top wall of the incubator 1, a pulley III 21 is arranged below each pulley II 11, the pulley II 11 and the pulley III 21 are fixedly connected with the side wall of the incubator 1, a pull rope 4 is fixedly connected to the upper side of the door 5, one end, away from the door 5, of the pull rope 4 penetrates through the pulley I9, the pulley II, the clamp 15 is clamped below the protruding portion 7, the handle 33 is rotated, the handle 33 drives the left and right screw rods 8 to rotate through the belt 23, the nuts 14 on the left and right sides drive the incubator 3 to move upwards, and the hydraulic cylinder 32 drives the upper left and right box doors 5 to rotate upwards through the pull rope 4 in the process of moving upwards, so that the box doors 5 are opened.
Further, in order to facilitate the detection and adjustment of the temperature around the incubator 3, in this embodiment, a temperature detector 6 is disposed above the incubator 3, and heating lamps 2 are disposed on the lower surfaces of the left and right sides of the chamber door 5.
Further, in order to improve the stability of the nut 14 moving up and down in the vertical direction, in this embodiment, the left and right side walls in the incubator 1 are symmetrically provided with the limiting grooves 13, the nut 14 is fixedly connected with the limiting seat 17, and the limiting seat 17 is slidably connected with the limiting grooves 13.
Further, in order to improve the shock attenuation effect in incubator 1, in this embodiment, the symmetry of incubator 1 diapire upper surface left and right sides sets up support 27, the left and right sides set up guide arm 28 between support 27, the symmetry of guide arm 28 left and right sides sets up damping spring 29, damping spring 29 and damper 20 fixed connection, damper 20 and guide arm 28 sliding connection, damper 20 top swing joint shock attenuation pole 30, the one end swing joint supporting platform 19 of damper 20 is kept away from to shock attenuation pole 30, supporting platform 19 upper surface is arranged in to incubator 3.
Furthermore, in order to improve the buffering effect between the incubator 3 and the supporting platform 19, in this embodiment, the buffering pad 18 is disposed on the upper surface of the supporting platform 19.
Further, in order to improve the friction between the clamp 15 and the incubator 3 and avoid slipping, in this embodiment, the inner side wall surfaces of the clamp 15 on the left and right sides are all provided with anti-slip lines.
Example 2
Please refer to fig. 1-3, in order to adjust the height of the thermostat 1 conveniently, a supporting base 26 is arranged below the thermostat 1, supports the left and right sides of the upper surface of the supporting base 26 and symmetrically sets a bracket 24, the left and right sides of the lower surface of the bottom wall of the thermostat 1 symmetrically sets a storage cabinet 25, the left and right sides of the storage cabinet 25 symmetrically sets a rack plate 31, the left and right sides of the rack 24 are close to one end of the bracket 24, the rack 12 is fixedly connected with a gear 12, the gear 12 is meshed with the rack plate 31 and rotates through the gear 12, the gear 12 drives the storage cabinet 25 and the thermostat 1 above to move up and down in the vertical direction through being meshed with the rack plate 31, and the height adjustment is realized.
Example 3
The extraction method of the viral vaccine strain extraction device as described in the embodiments 1 and 2 comprises the following steps:
s1, the hydraulic cylinder 32 pushes the telescopic rod 16 to drive the left and right clamps 15 to move inwards at the same time, and the clamps 15 are clamped below the convex part 7;
s2, rotating a handle 33, wherein the handle 33 drives a left screw 8 and a right screw 8 to rotate through a belt 23, the nuts 14 on the left side and the right side drive the incubator 3 to move upwards, and the hydraulic cylinder 32 drives the upper left box door 5 and the upper right box door 5 to rotate upwards through a pull rope 4 in the process of moving upwards, so that the box doors 5 are opened;
s3, by rotating the gear 12, the gear 12 is meshed with the rack plate 31 to drive the storage cabinet 25 and the thermostat 1 above to move up and down in the vertical direction, and therefore height adjustment is achieved.
While the preferred embodiments of the present invention have been described in detail, the present invention is not limited to the above embodiments, and various changes can be made without departing from the spirit of the present invention within the knowledge of those skilled in the art.

Claims (8)

1. The utility model provides a viral bacterin strain extraction element, includes thermostated container (1) and incubator (3), its characterized in that, install incubator (3) in thermostated container (1), left and right sides symmetry sets up screw rod (8) in thermostated container (1), both sides rotate with thermostated container (1) lateral wall about screw rod (8) and are connected, bottom wall sets up cavity (22) in thermostated container (1), the left and right sides screw rod (8) below is passed through belt (23) and is rotated the connection, belt (23) are installed in cavity (22), the left side screw rod (8) bottom end extends fixed connection handle (33), screw rod (8) surface sets up nut (14), the left and right sides one end fixed connection pneumatic cylinder (32) that nut (14) are close to each other, telescopic link (16) is connected to pneumatic cylinder (32), one end fixed connection anchor clamps (15) of pneumatic cylinder (32) are kept away from in telescopic link (16), a plurality of convex parts (7) are arranged on the surface of the outer side wall of the incubator (3) at equal intervals, the left side and the right side of the top wall of the incubator (1) are symmetrically provided with the box doors (5), the box doors (5) on the left side and the right side are rotatably connected with the side wall of the incubator (1), the left side and the right side of the upper surface of the top wall of the constant temperature box (1) are symmetrically provided with supporting rods (10), one end of the support rod (10) far away from the thermostat (1) is connected with a first pulley (9), the left end and the right end of the top wall of the constant temperature box (1) are symmetrically and transversely provided with a second pulley (11), a pulley III (21) is arranged below the pulley II (11), the pulley II (11) and the pulley III (21) are fixedly connected with the side wall of the incubator (1), a pull rope (4) is fixedly connected above the box door (5), and one end, far away from the box door (5), of the pull rope (4) penetrates through the first pulley (9), the second pulley (11) and the third pulley (21) to be fixedly connected with the hydraulic cylinder (32).
2. A viral vaccine strain extraction device as defined in claim 1, wherein a temperature detector (6) is arranged above the incubator (3), and heating warmers (2) are arranged on the lower surfaces of the left and right chamber doors (5).
3. A viral vaccine strain extraction apparatus as claimed in claim 1 or 2, wherein the thermostat (1) is provided with a limiting groove (13) on the left and right side walls symmetrically, the nut (14) is fixedly connected with a limiting seat (17), and the limiting seat (17) is slidably connected with the limiting groove (13).
4. A viral vaccine strain extraction device according to claim 3, characterized in that supports (27) are symmetrically arranged on the left side and the right side of the upper surface of the bottom wall of the incubator (1), guide rods (28) are arranged between the supports (27) on the left side and the right side, damping springs (29) are symmetrically arranged on the left side and the right side of the guide rods (28), the damping springs (29) are fixedly connected with the damping seat (20), the damping seat (20) is slidably connected with the guide rods (28), a damping rod (30) is movably connected above the damping seat (20), one end of the damping rod (30) far away from the damping seat (20) is movably connected with the supporting platform (19), and the upper surface of the supporting platform (19) is arranged in the incubator (3).
5. A viral vaccine strain extraction device and method as claimed in claim 4, wherein the support platform (19) is provided with a cushion (18) on its upper surface.
6. A viral vaccine strain extraction device and method as claimed in claim 5, characterized in that the surface of the inner side wall of the clamp (15) on the left and right sides is provided with anti-skid lines.
7. A viral vaccine strain extraction device and an extraction method thereof according to claim 6, characterized in that a support base (26) is arranged below the incubator (1), supports (24) are symmetrically arranged on the left side and the right side of the upper surface of the support base (26), storage cabinets (25) are symmetrically arranged on the left side and the right side of the lower surface of the bottom wall of the incubator (1), rack plates (31) are symmetrically arranged on the left side and the right side of the storage cabinets (25), one ends of the supports (24) on the left side and the right side, which are close to each other, are fixedly connected with a gear (12) through a connecting rod, the gear (12) is fixedly connected with a driving mechanism, and the gear (12) is meshed with the rack plates (.
8. The extraction method of the virus vaccine strain extraction device according to any one of claims 1 to 7, characterized by comprising the following steps:
s1, the hydraulic cylinder (32) pushes the telescopic rod (16) to drive the left clamp and the right clamp (15) to move inwards at the same time, and the clamps (15) are clamped below the protruding parts (7);
s2, rotating a handle (33), wherein the handle (33) drives a screw rod (8) on the left side and the right side to rotate through a belt (23), nuts (14) on the left side and the right side drive an incubator (3) to move upwards, and a hydraulic cylinder (32) drives the upper left box door (5) and the upper right box door (5) to rotate upwards through a pull rope (4) in the process of moving upwards, so that the box doors (5) are opened;
s3, the gear (12) is meshed with the rack plate (31) to drive the storage cabinet (25) and the thermostat (1) above to move up and down in the vertical direction, and therefore height adjustment is achieved.
CN202011384061.4A 2020-12-01 2020-12-01 Viral vaccine strain extraction device and extraction method thereof Pending CN112481125A (en)

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Application publication date: 20210312