CN109294912A - One kind rubbing formula biological cell and freezes a bag dry type recovery device - Google Patents
One kind rubbing formula biological cell and freezes a bag dry type recovery device Download PDFInfo
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- CN109294912A CN109294912A CN201811241219.5A CN201811241219A CN109294912A CN 109294912 A CN109294912 A CN 109294912A CN 201811241219 A CN201811241219 A CN 201811241219A CN 109294912 A CN109294912 A CN 109294912A
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- plate
- dry type
- freezes
- biological cell
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M23/00—Constructional details, e.g. recesses, hinges
- C12M23/02—Form or structure of the vessel
- C12M23/12—Well or multiwell plates
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M23/00—Constructional details, e.g. recesses, hinges
- C12M23/48—Holding appliances; Racks; Supports
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- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
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- Wood Science & Technology (AREA)
- Sustainable Development (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Clinical Laboratory Science (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Abstract
Formula biological cell, which is rubbed, the invention discloses one kind freezes a bag dry type recovery device, belong to biotechnological device technical field, including firm banking, firm banking upper end is equipped with falsework, falsework upper end is equipped with support plate, firm banking upper end two sides are equipped with limitting casing, screw rod is installed inside limitting casing, lifter plate is connected with by internal thread hole in the middle part of screw rod, lifter plate front center is equipped with rotary shaft, rotary shaft front end passes through lifting front edge of board and is connected with rotating wheel, rotating wheel front end is equipped with gantry column, swing set is installed on the outside of gantry column, it swings and oscillating rod is installed in the middle part of set both ends, oscillating rod lower end two sides are equipped with fixed column, fixed column lower end, which is connected with, rubs plate.The present invention realizes and moves up and down to rubbing plate, while the gantry column by being equipped with and swinging the cooperation between set, realizes and moves left and right to rubbing plate, to guarantee the dry type Effect of Resuscitation for freezing bag to biological cell.
Description
Technical field
The present invention relates to biotechnological device technical field, specifically a kind of formula biological cell that rubs freezes a bag dry type recovery
Device.
Background technique
There is no unified definition for cell (English name: cell), and commonplace formulation is: cell is that organism is basic
Structure and function unit.Known all biologies in addition to virus are made of cell, but viral life activity is also necessary
It could be embodied in cell.
With the development of science and technology, cell therapy technology is quickly grown, mainly including stem cell therapy and with CAR-T cell
To represent immune cell therapy.Cell involved in cell product preparation process freeze and defrosting of recovering.When cell recovery thaws,
Optimum operation is to cause to damage to cell to reduce by being just rapidly heated by the cell cryopreservation bag that liquid nitrogen container takes out to 37 DEG C.Mesh
The resuscitation of preceding cell cryopreservation bag is mostly used 37 DEG C of heating water baths, and not only operating process is not easy to standardize, and is easy contamination of cells.
The dry type recovery of cell cryopreservation bag more meets the GMP specification process of cell preparation production.
The open one kind of Chinese patent (notification number: CN207775247U) rubs formula cell cryopreservation bag dry type recovery instrument, including
Multiple heating devices and pressure altering device, although the device increases cell defrosting ability, the dress to a certain extent
It sets and realizes cell recovery merely by pumping, only realize the pressing mode rubbed in movement, there is no true
The movement rubbed in positive meaning, still cannot achieve cell cryopreservation bag and efficiently recovers, reliability is not high.
Summary of the invention
Formula biological cell is rubbed the purpose of the present invention is to provide one kind and freezes a bag dry type recovery device, to solve above-mentioned back
The problem of being proposed in scape technology.
To achieve the above object, the invention provides the following technical scheme:
One kind rubbing formula biological cell and freezes a bag dry type recovery device, including firm banking, firm banking upper end are equipped with work
Frame, falsework upper end are equipped with support plate, and support plate upper end is equipped with workbench, and workbench upper end is uniformly provided with putting hole, institute
It states firm banking upper end two sides and limitting casing is installed, screw rod is installed inside limitting casing, is connected in the middle part of screw rod by internal thread hole
There is lifter plate, lifter plate front center is equipped with rotary shaft, and rotary shaft front end passes through lifting front edge of board and is connected with rotating wheel, rotates
Wheel front end is equipped with gantry column, and swing set is equipped on the outside of gantry column, swings and is equipped with oscillating rod in the middle part of set both ends, under oscillating rod
End two sides are equipped with fixed column, and fixed column lower end, which is connected with, rubs plate.
As a further solution of the present invention: pedestal lower end two sides are equipped with supporting leg.
As a further solution of the present invention: the limitting casing top is equipped with fixed plate, and dead plate upper end is equipped with drive
Dynamic case.
As a further solution of the present invention: the screw mandrel top passes through fixed plate and is connected with driving gear set, driving cog
Transmission shaft is connected between wheel group.
As a further solution of the present invention: the transmission shaft right end passes through driving box and is connected with driving motor.
As a further solution of the present invention: the rotation shaft rear end passes through lifter plate and is fixedly installed with rotating electric machine.
As a further solution of the present invention: the oscillating rod upper and lower ends are equipped with guide post, and guide post is fixed on liter
It drops in the middle part of front edge of board.
As a further solution of the present invention: the plate lower end that rubs is equipped with heating plate.
As further scheme of the invention: being equipped with lower heating plate inside the workbench.
Compared with prior art, the beneficial effects of the present invention are:
Described one kind rubs formula biological cell and freezes a bag dry type recovery device, structurally reasonable, novel in design, passes through the screw rod being equipped with
Cooperation between lifter plate realizes and moves up and down to rubbing plate, while the gantry column by being equipped with and swinging between set
Cooperation, realize and move left and right to rubbing plate, to guarantee the dry type Effect of Resuscitation for freezing bag to biological cell, significantly
Increase the recovery quality and recovery efficiency of cell, practical, high reliablity.
Detailed description of the invention
Fig. 1 is that a kind of formula biological cell that rubs freezes a bag structural schematic diagram for dry type recovery device.
Fig. 2 is a kind of structural schematic diagram for rubbing formula biological cell and freezing lifter plate in bag dry type recovery device.
Fig. 3 is a kind of overlooking structure diagram for rubbing formula biological cell and freezing workbench in bag dry type recovery device.
Fig. 4 is that a kind of formula biological cell that rubs freezes a bag structural representation for another embodiment of dry type recovery device
Figure.
In figure: 1- firm banking, 2- supporting leg, 3- limitting casing, 4- lifter plate, 5- screw rod, 6- driving box, 7- transmission shaft,
8- driving motor, 9- fixed plate, 10- driving gear set, 11- rotating wheel, 12- rotary shaft, 13- guide post, 14- oscillating rod, 15-
Fixed column, 16- rub the upper heating plate of plate, 17-, 18- falsework, 19- workbench, 20- support plate, 21- putting hole, spiral shell in 22-
Heating plate, 24- gantry column under pit, 23-.
Specific embodiment
It should be noted that in the absence of conflict, the feature in embodiment and embodiment in the present invention can phase
Mutually combination.
In the description of the present invention, it is to be understood that, term " center ", " longitudinal direction ", " transverse direction ", "upper", "lower",
The orientation or positional relationship of the instructions such as "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outside" is
It is based on the orientation or positional relationship shown in the drawings, is merely for convenience of description of the present invention and simplification of the description, rather than instruction or dark
Show that signified device or element must have a particular orientation, be constructed and operated in a specific orientation, therefore should not be understood as pair
Limitation of the invention.In addition, term " first ", " second " etc. are used for description purposes only, it is not understood to indicate or imply phase
To importance or implicitly indicate the quantity of indicated technical characteristic.The feature for defining " first ", " second " etc. as a result, can
To explicitly or implicitly include one or more of the features.In the description of the present invention, unless otherwise indicated, " multiple "
It is meant that two or more.
In the description of the present invention, it should be noted that unless otherwise clearly defined and limited, term " installation ", " phase
Even ", " connection " shall be understood in a broad sense, for example, it may be being fixedly connected, may be a detachable connection, or be integrally connected；It can
To be mechanical connection, it is also possible to be electrically connected；It can be directly connected, can also can be indirectly connected through an intermediary
Connection inside two elements.For the ordinary skill in the art, above-mentioned term can be understood by concrete condition
Concrete meaning in the present invention.
The present invention will be described in detail below with reference to the accompanying drawings and embodiments.
Embodiment 1
Refering to fig. 1, in the embodiment of the present invention, one kind rubbing formula biological cell and freezes a bag dry type recovery device, including firm banking
1, the 1 lower end two sides of firm banking are equipped with supporting leg 2, and the support for realizing whole device is fixed, on firm banking 1
End is equipped with falsework 18, and 18 upper end of falsework is equipped with support plate 20, and 20 upper end of support plate is equipped with workbench 19, described solid
Determine 1 upper end two sides of pedestal and limitting casing 3 is installed, 3 top of limitting casing is equipped with fixed plate 9, and 9 upper end of fixed plate is equipped with drive
Dynamic case 6 is equipped with screw rod 5, the screw rod for being sealed between driving gear set 10 and transmission shaft 7 inside limitting casing 3
5 tops pass through fixed plate 9 and are connected with driving gear set 10, transmission shaft 7 are connected between driving gear set 10, and then ensure two
The synchronous rotation of a screw rod 5,7 right end of transmission shaft passes through driving box 6 and is connected with driving motor 8, for ensuring screw rod 5
Rotation, 4 front center of lifter plate are equipped with rotary shaft 12, and 12 rear end of rotary shaft passes through lifter plate 4 and is fixedly installed with rotation
Motor, for driving rotary shaft 12 to be rotated, 12 front end of rotary shaft passes through 4 front end of lifter plate and is connected with rotating wheel 11, revolves
11 front end of runner is equipped with gantry column 24, and swing set 25 is equipped on the outside of gantry column 24, swings and is equipped with pendulum in the middle part of 25 both ends of set
Lever 14,14 upper and lower ends of oscillating rod are equipped with guide post 13, for limiting to moving left and right for oscillating rod 14, keep away
Exempt from it to teetertotter, guide post 13 is fixed on 4 front center of lifter plate, and 14 lower end two sides of oscillating rod are equipped with fixed column
15,15 lower end of fixed column, which is connected with, rubs plate 16, and 16 lower end of plate that rubs is equipped with heating plate 17, for realizing cell
Freeze the heating thaw effects of bag upper end.
Referring to Fig.2, being connected with lifter plate 4 by internal thread hole 22 in the middle part of the screw rod 5, and then the rotation of screw rod 5 is transported
Turn turns to the linear motion up and down of lifter plate 4, so that it is guaranteed that lifter plate 4 pressing effect.
Refering to Fig. 3,19 upper end of workbench is uniformly provided with putting hole 21, freezes for placing the multiple cells for needing to recover
Bag is deposited, realizes and disposably freezes a bag Effect of Resuscitation to multiple.
Embodiment 2
In another embodiment of the invention, the difference of the embodiment and above-described embodiment is, pacifies inside the workbench 19
Equipped with lower heating plate 23, for further carrying out heating defrosting to freezing bag lower end, it is ensured that the dry type recovery efficiency of cell.
The present invention, in use, the cell cryopreservation bag recovered will be needed to be put in putting hole 21, so that lower heating plate 23 remains
Heating effect, while starting driving motor 8, driving motor 8 passes through the transmission shaft 7 and driving gear set 10 inside driving box 6
Effect, so that lifter plate 4 drives and rubs plate 16 and move down, be contacted with until rubbing plate 16 so that screw rod 5 rotates
Cell cryopreservation bag upper end, while heating plate 17 being made to remain heating effect, on the other hand, so that rotating electric machine starting drives
Rotary shaft 12 rotated, and then drive rotating wheel 11 and gantry column 24 to rotate synchronously, and then matched with set 25 is swung
It closes, so that oscillating rod 14 drives fixed link 15 to swing back and forth along guide post 13 or so, so that rubbing plate 16 to cell
Freeze bag carry out left and right rub, realize dry type Effect of Resuscitation, again during, constantly regulate and rub plate 16 and cell cryopreservation
Distance up and down between bag, it is ensured that pressing plate 16 can be with real-time contact to freezing bag.The present invention, it is structurally reasonable, it is novel in design,
It by the cooperation between the screw rod 5 being equipped with and lifter plate 4, realizes to rubbing moving up and down for plate 16, while by being equipped with
Gantry column and the cooperation between set is swung, realizes and move left and right to rubbing plate, to guarantee to freeze bag to biological cell
Dry type Effect of Resuscitation, greatly increase the recovery quality and recovery efficiency of cell, practical, high reliablity.
The foregoing is merely illustrative of the preferred embodiments of the present invention, is not intended to limit the invention, all in essence of the invention
Within mind and principle, any modification, equivalent replacement, improvement and so on be should all be included in the protection scope of the present invention.
Claims (9)
1. one kind rubs formula biological cell and freezes a bag dry type recovery device, including firm banking (1), firm banking (1) upper end peace
Equipped with falsework (18), falsework (18) upper end is equipped with support plate (20), and support plate (20) upper end is equipped with workbench (19),
Workbench (19) upper end is uniformly provided with putting hole (21), which is characterized in that firm banking (1) the upper end two sides are equipped with limit
Frame (3), limitting casing (3) is internal to be equipped with screw rod (5), is connected with lifter plate (4) by internal thread hole (22) in the middle part of screw rod (5),
Lifter plate (4) front center is equipped with rotary shaft (12), and rotary shaft (12) front end passes through lifter plate (4) front end and is connected with rotating wheel
(11), rotating wheel (11) front end is equipped with gantry column (24), and swing set (25) is equipped on the outside of gantry column (24), swings set (25)
It is equipped with oscillating rod (14) in the middle part of both ends, oscillating rod (14) lower end two sides are equipped with fixed column (15), and fixed column (15) lower end connects
It is connected to and rubs plate (16).
2. one kind according to claim 1 rubs formula biological cell and freezes a bag dry type recovery device, which is characterized in that described
Firm banking (1) lower end two sides are equipped with supporting leg (2).
3. one kind according to claim 1 rubs formula biological cell and freezes a bag dry type recovery device, which is characterized in that described
Limitting casing (3) top is equipped with fixed plate (9), and fixed plate (9) upper end is equipped with driving box (6).
4. one kind according to claim 1 rubs formula biological cell and freezes a bag dry type recovery device, which is characterized in that described
Screw rod (5) top passes through fixed plate (9) and is connected with driving gear set (10), and driving gear set is connected with transmission shaft between (10)
(7).
5. one kind according to claim 4 rubs formula biological cell and freezes a bag dry type recovery device, which is characterized in that described
Transmission shaft (7) right end passes through driving box (6) and is connected with driving motor (8).
6. one kind according to claim 1 rubs formula biological cell and freezes a bag dry type recovery device, which is characterized in that described
Rotary shaft (12) rear end passes through lifter plate (4) and is fixedly installed with rotating electric machine.
7. one kind according to claim 1 rubs formula biological cell and freezes a bag dry type recovery device, which is characterized in that described
Oscillating rod (14) upper and lower ends are equipped with guide post (13), and guide post (13) is fixed on lifter plate (4) front center.
8. one kind according to claim 1 rubs formula biological cell and freezes a bag dry type recovery device, which is characterized in that described
It rubs plate (16) lower end and heating plate (17) is installed.
9. one kind according to claim 1 rubs formula biological cell and freezes a bag dry type recovery device, which is characterized in that described
Lower heating plate (23) are installed inside workbench (19).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811241219.5A CN109294912A (en) | 2018-10-24 | 2018-10-24 | One kind rubbing formula biological cell and freezes a bag dry type recovery device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811241219.5A CN109294912A (en) | 2018-10-24 | 2018-10-24 | One kind rubbing formula biological cell and freezes a bag dry type recovery device |
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| Publication Number | Publication Date |
|---|---|
| CN109294912A true CN109294912A (en) | 2019-02-01 |
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ID=65158289
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201811241219.5A Withdrawn CN109294912A (en) | 2018-10-24 | 2018-10-24 | One kind rubbing formula biological cell and freezes a bag dry type recovery device |
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| CN (1) | CN109294912A (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110157599A (en) * | 2019-07-10 | 2019-08-23 | 陕西中医药大学 | A kind of culture device of pilot scale culture umbilical cord mesenchymal stem cells |
| CN110305786A (en) * | 2019-06-20 | 2019-10-08 | 大连理工大学 | A kind of hand-held, can be from the dry type cell resuscitator of disinfection |
| CN112481125A (en) * | 2020-12-01 | 2021-03-12 | 江苏中慧元通生物科技有限公司 | Viral vaccine strain extraction device and extraction method thereof |
| CN114410468A (en) * | 2022-01-26 | 2022-04-29 | 衷博瑞佳生物技术(上海)有限公司 | High-efficient biological cell recovery equipment |
-
2018
- 2018-10-24 CN CN201811241219.5A patent/CN109294912A/en not_active Withdrawn
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110305786A (en) * | 2019-06-20 | 2019-10-08 | 大连理工大学 | A kind of hand-held, can be from the dry type cell resuscitator of disinfection |
| CN110157599A (en) * | 2019-07-10 | 2019-08-23 | 陕西中医药大学 | A kind of culture device of pilot scale culture umbilical cord mesenchymal stem cells |
| CN112481125A (en) * | 2020-12-01 | 2021-03-12 | 江苏中慧元通生物科技有限公司 | Viral vaccine strain extraction device and extraction method thereof |
| CN114410468A (en) * | 2022-01-26 | 2022-04-29 | 衷博瑞佳生物技术(上海)有限公司 | High-efficient biological cell recovery equipment |
| CN114410468B (en) * | 2022-01-26 | 2024-05-28 | 衷博瑞佳生物技术(上海)有限公司 | High-efficient biological cell resuscitator |
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| WW01 | Invention patent application withdrawn after publication |
Application publication date: 20190201 |
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| WW01 | Invention patent application withdrawn after publication |