CN112469421A - 减少剪接病和治疗rna显性疾病的组合物和方法 - Google Patents

减少剪接病和治疗rna显性疾病的组合物和方法 Download PDF

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CN112469421A
CN112469421A CN201980047374.XA CN201980047374A CN112469421A CN 112469421 A CN112469421 A CN 112469421A CN 201980047374 A CN201980047374 A CN 201980047374A CN 112469421 A CN112469421 A CN 112469421A
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nucleic acid
rna
acid sequence
interfering rna
viral vector
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J·张伯伦
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University of Washington
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University of Washington
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CN201980047374.XA 2018-05-15 2019-05-15 减少剪接病和治疗rna显性疾病的组合物和方法 Pending CN112469421A (zh)

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US201862671769P 2018-05-15 2018-05-15
US62/671,769 2018-05-15
PCT/US2019/032423 WO2019222354A1 (en) 2018-05-15 2019-05-15 Compositions and methods for reducing spliceopathy and treating rna dominance disorders

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US (1) US20210269825A1 (https=)
EP (1) EP3793566A4 (https=)
JP (1) JP2021522836A (https=)
KR (1) KR20210010549A (https=)
CN (1) CN112469421A (https=)
AU (1) AU2019268346A1 (https=)
BR (1) BR112020023298A2 (https=)
CA (1) CA3098249A1 (https=)
CL (1) CL2020002955A1 (https=)
CO (1) CO2020015239A2 (https=)
MA (1) MA51938B1 (https=)
MX (1) MX2020012269A (https=)
PH (1) PH12020551913A1 (https=)
SG (1) SG11202011151VA (https=)
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CN113166208B (zh) 2018-10-02 2024-11-22 沃雅戈治疗公司 重新定向aav衣壳的嗜性
TWI900553B (zh) 2020-05-13 2025-10-11 美商航海家醫療公司 Aav蛋白殼之趨性重定向
WO2023034870A2 (en) 2021-09-01 2023-03-09 Ionis Pharmaceuticals, Inc. Compounds and methods for reducing dmpk expression
EP4426716A1 (en) 2021-11-02 2024-09-11 Voyager Therapeutics, Inc. Aav capsid variants and uses thereof
WO2023196862A1 (en) * 2022-04-06 2023-10-12 Genzyme Corporation Targeted gene therapy for dm-1 myotonic dystrophy
US20250352672A1 (en) * 2022-05-13 2025-11-20 University Of Washington Method for treatment of myotonic dystrophy combining protein expression and rna interference vector delivery with tissue detargeting
TW202409289A (zh) * 2022-06-27 2024-03-01 美商安斯泰來基因治療股份有限公司 用於治療肌強直性營養不良之組合物及方法
US20240384271A1 (en) * 2023-04-05 2024-11-21 Genzyme Corporation Targeted gene therapy for dm-1 myotonic dystrophy
WO2024229164A2 (en) * 2023-05-03 2024-11-07 Voyager Therapeutics, Inc. Compositions and methods for the treatment of disorders related to dystrophia myotonica protein kinase
WO2025038795A1 (en) * 2023-08-16 2025-02-20 Voyager Therapeutics, Inc. Compositions and methods for the treatment of disorders related to dystrophia myotonica protein kinase
WO2025122536A1 (en) * 2023-12-05 2025-06-12 Voyager Therapeutics, Inc. Compositions and methods for the treatment of disorders related to dystrophia myotonica protein kinase
WO2025259747A2 (en) * 2024-06-12 2025-12-18 Alnylam Pharmaceuticals, Inc. Dystrophy myotonic protein kinase (dmpk) irna compositions and methods of use thereof

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PH12020551913A1 (en) 2021-06-14
BR112020023298A2 (pt) 2021-03-09
EP3793566A4 (en) 2022-03-16
MA51938A1 (fr) 2021-11-30
MA51938B1 (fr) 2022-10-31
WO2019222354A1 (en) 2019-11-21
MX2020012269A (es) 2021-04-28
KR20210010549A (ko) 2021-01-27
US20210269825A1 (en) 2021-09-02
JP2021522836A (ja) 2021-09-02
SG11202011151VA (en) 2020-12-30
EP3793566A1 (en) 2021-03-24
AU2019268346A1 (en) 2020-12-24
CO2020015239A2 (es) 2021-03-08
CA3098249A1 (en) 2019-11-21
CL2020002955A1 (es) 2021-04-23

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