CN112451728A - Bioactive glass dressing for human skin tissue recovery and preparation method thereof - Google Patents

Abstract

The invention belongs to the technical field of medical dressings, in particular to a bioactive glass dressing for human skin tissue recovery and a preparation method thereof, wherein the bioactive glass dressing comprises the following raw materials: petrolatum, bioactive glass, collagen, chitosan, cocoa butter, humectants, cross-linking agents, and antioxidants. The invention can provide good healing environment for wound healing through the moisture tightness and good sterilization and disinfection effects of vaseline gauze, the bioactive glass promotes the synthesis and secretion of collagen and epithelial growth factors, and actively induces the proliferation, differentiation and migration of epithelial cells, thereby effectively promoting the wound healing, the chitosan and cocoa butter are compounded, the lubrication degree of the wound can be improved, the wound is prevented from being adhered when the dressing is taken down, the wound is damaged, the humectant can preserve moisture, also has a certain plasticizing effect, the toughness and tensile strength of the dressing can be effectively improved, and the dressing plays a vital role in the softness after swelling and the skin adhesion.

Description

Bioactive glass dressing for human skin tissue recovery and preparation method thereof

Technical Field

The invention relates to the technical field of medical dressings, in particular to a bioactive glass dressing for human skin tissue recovery and a preparation method thereof.

Background

The most remarkable characteristic of the bioactive glass and the glass ceramic is that after the bioactive glass and the glass ceramic are implanted into a human body, the surface condition dynamically changes along with time, and a bioactive Hydroxyapatite (HCA) layer is formed on the surface, so that a bonding interface is provided for tissues. Most bioactive glass is a class A bioactive material, has osteogenesis and bone guiding effects, has good binding property with bones and soft tissues, and BAG is considered to be a good biomaterial applicable to the field of repair. The application of the restorative material is extremely wide, and the restorative material has irreplaceable miraculous effects on professional products in various fields, such as skin care, whitening and wrinkle removal, burns and scalds, oral ulcer, gastrointestinal ulcer, skin ulceration, fungus killing, bone repair, bonding of soft tissues and bone tissues and the like, and the occurrence of the restorative material is believed to make a remarkable contribution to human health. In addition, BAG also has a rapid surface reaction; the amorphous two-dimensional structure causes low strength and fracture toughness; the elastic modulus (30-35MPa) is low and is close to that of cortical bone; the invention discloses a medical liquid dressing and a preparation method thereof, and aims to provide a medical liquid dressing which has long-acting broad-spectrum antibacterial property, reduces scar formation and has good treatment effect on wound healing, wherein the machinable bioglass has good processing performance and the application number is CN 201310240323.3; the technical key points are as follows: the medical liquid dressing contains 0.02-1% of solid components and the balance of water; the solid components comprise 10-80% of chitosan quaternary ammonium salt, 20-90% of organosilicon quaternary ammonium salt and 6-30% of auxiliary materials; the preparation method comprises the following steps: filling water into a stirring tank, setting the stirring speed of a stirrer to be 30-35 r/min, adding the chitosan quaternary ammonium salt, and stirring to completely dissolve the chitosan quaternary ammonium salt for about 2-3 hours; adding the organic silicon quaternary ammonium salt solution and the chlorhexidine gluconate solution while stirring, and fully stirring for 1-2 hours to obtain a mixed solution; filtering the mixed solution, placing in a container, removing bubbles overnight, measuring the next day, obtaining a semi-finished product with solid content of 0.02-1% and pH value of 4.1-7.5, and subpackaging in a bottle body after the semi-finished product is qualified in aseptic test to obtain a finished product; belongs to the technical field of medicine preparation.

The invention provides a bioactive glass dressing for human skin tissue recovery and a preparation method thereof, aiming at solving the problems that the prior dressing for human skin tissue recovery still often leaves wound scars after promoting wound healing, can provide a good healing environment for wounds, and has poor wound surface scar removing effect and unsatisfactory antibacterial effect.

Disclosure of Invention

Technical problem to be solved

Aiming at the defects of the prior art, the invention provides a bioactive glass dressing for human skin tissue recovery and a preparation method thereof, and solves the problem that the existing dressing for human skin tissue recovery has poor wound healing promotion effect.

(II) technical scheme

In order to achieve the purpose, the invention provides the following technical scheme: a bioactive glass dressing for the restoration of human skin tissue, comprising the following raw materials: petrolatum, bioactive glass, collagen, chitosan, cocoa butter, humectants, cross-linking agents, and antioxidants.

The invention relates to a preferable technical scheme, which comprises the following components in parts by weight: 70-80 parts of vaseline, 10-20 parts of bioactive glass, 5-10 parts of collagen, 0.5-1 part of chitosan, 0.05-0.1 part of cocoa seed fat, 5-15 parts of humectant, 0.05-0.15 part of cross-linking agent and 0.1-0.2 part of antioxidant.

As a preferred technical scheme of the invention, the bioactive glass comprises the following components in parts by weight: 45-50% of SiO2, 4-6% of P2O5, 20-25% of Na2O and 25-35% of CaO, wherein the sum of the contents of the components is 100%.

As a preferable technical scheme of the invention, the chitosan is any one of chitosan iodine, chitosan quaternary ammonium salt or carboxymethyl chitosan.

As a preferable technical scheme of the invention, the humectant is one or a combination of more of glycerin, sorbitol, butanediol, polyglycerol-10, propylene glycol and ethylhexyl glycerin.

In a preferred embodiment of the present invention, the crosslinking agent is one or a combination of potassium citrate, calcium chloride, sodium chloride and potassium chloride.

As a preferable technical scheme of the invention, the antioxidant is one or a combination of more of phenoxyethanol, methyl paraben, ethyl paraben and polylysine.

The invention also provides a preparation method of the bioactive glass dressing for restoring the skin tissues of the human body, which comprises the following steps:

s1, fully stirring and dissolving vaseline, bioactive glass, collagen and chitosan, adding cocoa seed fat, and uniformly mixing to obtain a component A;

s2, sequentially adding the humectant, the cross-linking agent and the antioxidant into the component A in the step S1, and uniformly stirring to obtain a component B;

s3, heating the component B in the step S2 to any temperature between 75 ℃ and 85 ℃ for full dissolution, keeping the dissolution temperature constant for 30 minutes, standing, naturally cooling, and keeping the temperature constant when the temperature is reduced to 50 ℃;

s4, coating or tape-casting the preparation preserved at the constant temperature of 50 ℃ in the step 3 to form a film, dehydrating and drying the film at any temperature of 25-85 ℃ by adopting microwave or infrared dehydration drying equipment to form a dry film, then coating a protective film, rolling to form a film, cutting to form a shape, packaging and sealing.

(III) advantageous effects

Compared with the prior art, the invention provides the bioactive glass dressing for human skin tissue recovery and the preparation method thereof, and the bioactive glass dressing has the following beneficial effects:

the bioactive glass dressing for restoring the skin tissue of the human body and the preparation method thereof can provide a good healing environment for healing of a wound surface through the moisture tightness and good sterilization and disinfection effects of vaseline gauze, the bioactive glass promotes the synthesis and secretion of collagen and epithelial growth factors and actively induces the proliferation, differentiation and migration of epithelial cells so as to effectively promote the healing of the wound surface, the chitosan and cocoa butter are compounded, the lubrication degree of the wound surface can be improved, the wound is prevented from being adhered when the dressing is taken down, the wound surface is damaged, the humectant plays a certain plasticizing effect except for moisture retention, the toughness and tensile strength of the dressing can be effectively improved, the softness and the application performance of the skin after the dressing is swelled are vital, the swelling speed of the dressing and the strength of the dressing after the dressing is swelled are determined by the use of the cross-linking agent, the superior antibacterial performance of the antioxidant has good cooperative action in the system, and the bioactive glass dressing prepared by the special formula ratio can provide good healing environment for wounds, has good wound surface scar removing effect and ideal antibacterial effect.

Drawings

FIG. 1 is a graph showing the test results of the present invention.

Detailed Description

The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

Example 1

Referring to fig. 1, the present invention provides the following technical solutions: a bioactive glass dressing for the restoration of human skin tissue, comprising the following raw materials: petrolatum, bioactive glass, collagen, chitosan, cocoa butter, humectants, cross-linking agents, and antioxidants.

Specifically, the composition comprises the following components in parts by weight: 70 parts of vaseline, 10 parts of bioactive glass, 5 parts of collagen, 0.5 part of chitosan, 0.05 part of cocoa butter, 5 parts of a humectant, 0.05 part of a cross-linking agent and 0.1 part of an antioxidant.

Specifically, the bioactive glass comprises the following components in parts by weight: 50% of SiO2, 5% of P2O5, 20% of Na2O and 25% of CaO, and the sum of the contents of the components is 100%.

Specifically, the chitosan is iodine chitosan

Specifically, the humectant is glycerin.

Specifically, the crosslinking agent is potassium citrate.

Specifically, the antioxidant is phenoxyethanol.

The invention also provides a preparation method of the bioactive glass dressing for restoring the skin tissues of the human body, which comprises the following steps:

s1, fully stirring and dissolving vaseline, bioactive glass, collagen and chitosan, adding cocoa seed fat, and uniformly mixing to obtain a component A;

s2, sequentially adding the humectant, the cross-linking agent and the antioxidant into the component A in the step S1, and uniformly stirring to obtain a component B;

s3, heating the component B in the step S2 to any temperature between 75 ℃ to fully dissolve the component B, keeping the dissolving temperature constant for 30 minutes, standing, naturally cooling, and keeping the temperature constant when the temperature is reduced to 50 ℃;

s4, coating or tape-casting the preparation preserved at the constant temperature of 50 ℃ in the step 3 to form a film, dehydrating and drying the film at any temperature of 25 ℃ by adopting microwave or infrared dehydration drying equipment to form a dry film, then coating a protective film, rolling to form a film, cutting to form a shape, packaging and sealing.

Example 2

Referring to fig. 1, the present invention provides the following technical solutions: a bioactive glass dressing for the restoration of human skin tissue, comprising the following raw materials: petrolatum, bioactive glass, collagen, chitosan, cocoa butter, humectants, cross-linking agents, and antioxidants.

Specifically, the composition comprises the following components in parts by weight: 74 parts of vaseline, 14 parts of bioactive glass, 6 parts of collagen, 0.6 part of chitosan, 0.08 part of cocoa butter, 8 parts of humectant, 0.08 part of cross-linking agent and 0.14 part of antioxidant.

Specifically, the bioactive glass comprises the following components in parts by weight: 48 percent of SiO2, 4 percent of P2O5, 20 percent of Na2O and 28 percent of CaO, and the sum of the contents of the components is 100 percent.

Specifically, the chitosan is chitosan quaternary ammonium salt.

Specifically, the humectant is glycerin.

Specifically, the crosslinking agent is calcium chloride.

Specifically, the method comprises the following steps: the antioxidant is methyl paraben.

The invention also provides a preparation method of the bioactive glass dressing for restoring the skin tissues of the human body, which comprises the following steps:

s1, fully stirring and dissolving vaseline, bioactive glass, collagen and chitosan, adding cocoa seed fat, and uniformly mixing to obtain a component A;

s2, sequentially adding the humectant, the cross-linking agent and the antioxidant into the component A in the step S1, and uniformly stirring to obtain a component B;

s3, heating the component B in the step S2 to any temperature between 78 ℃ for full dissolution, keeping the dissolution temperature constant for 30 minutes, standing, naturally cooling, and keeping the temperature constant when the temperature is reduced to 50 ℃;

s4, coating or tape-casting the preparation preserved at the constant temperature of 50 ℃ in the step 3 to form a film, dehydrating and drying the film at any temperature of 40 ℃ by adopting microwave or infrared dehydration drying equipment to form a dry film, then coating a protective film, rolling to form a film, cutting to form a shape, packaging and sealing.

Example 3

Referring to fig. 1, the present invention provides the following technical solutions: a bioactive glass dressing for the restoration of human skin tissue, comprising the following raw materials: petrolatum, bioactive glass, collagen, chitosan, cocoa butter, humectants, cross-linking agents, and antioxidants.

Specifically, the composition comprises the following components in parts by weight: 70-80 parts of vaseline, 18 parts of bioactive glass, 8 parts of collagen, 0.8 part of chitosan, 0.09 part of cocoa seed fat, 10 parts of humectant, 0.1 part of cross-linking agent and 0.18 part of antioxidant.

Specifically, the bioactive glass comprises the following components in parts by weight: 48 percent of SiO2, 6 percent of P2O5, 20 percent of Na2O and 26 percent of CaO, and the sum of the contents of the components is 100 percent.

Specifically, the chitosan is any one of chitosan iodine, chitosan quaternary ammonium salt or carboxymethyl chitosan.

Specifically, the humectant is polyglycerol-10.

Specifically, the crosslinking agent is sodium chloride.

Specifically, the antioxidant is polylysine.

The invention also provides a preparation method of the bioactive glass dressing for restoring the skin tissues of the human body, which comprises the following steps:

s1, fully stirring and dissolving vaseline, bioactive glass, collagen and chitosan, adding cocoa seed fat, and uniformly mixing to obtain a component A;

s2, sequentially adding the humectant, the cross-linking agent and the antioxidant into the component A in the step S1, and uniformly stirring to obtain a component B;

s3, heating the component B in the step S2 to any temperature between 80 ℃ for full dissolution, keeping the dissolution temperature constant for 30 minutes, standing, naturally cooling, and keeping the temperature constant when the temperature is reduced to 50 ℃;

s4, coating or tape-casting the preparation preserved at the constant temperature of 50 ℃ in the step 3 to form a film, dehydrating and drying the film at any temperature of 60 ℃ by adopting microwave or infrared dehydration drying equipment to form a dry film, then coating a protective film, rolling to form a film, cutting to form a shape, packaging and sealing.

Example 4

Referring to fig. 1, the present invention provides the following technical solutions: a bioactive glass dressing for the restoration of human skin tissue, comprising the following raw materials: petrolatum, bioactive glass, collagen, chitosan, cocoa butter, humectants, cross-linking agents, and antioxidants.

Specifically, the composition comprises the following components in parts by weight: 70-80 parts of vaseline, 20 parts of bioactive glass, 10 parts of collagen, 1 part of chitosan, 0.1 part of cocoa seed fat, 15 parts of a humectant, 0.15 part of a cross-linking agent and 0.2 part of an antioxidant.

Specifically, the bioactive glass comprises the following components in parts by weight: 46 percent of SiO2, 6 percent of P2O5, 22 percent of Na2O and 26 percent of CaO, and the sum of the contents of the components is 100 percent.

Specifically, the chitosan is chitosan quaternary ammonium salt.

Specifically, the humectant is glycerin.

Specifically, the crosslinking agent is potassium chloride.

Specifically, the method comprises the following steps: the antioxidant is polylysine.

The invention also provides a preparation method of the bioactive glass dressing for restoring the skin tissues of the human body, which comprises the following steps:

s1, fully stirring and dissolving vaseline, bioactive glass, collagen and chitosan, adding cocoa seed fat, and uniformly mixing to obtain a component A;

s2, sequentially adding the humectant, the cross-linking agent and the antioxidant into the component A in the step S1, and uniformly stirring to obtain a component B;

s3, heating the component B in the step S2 to any temperature between 85 ℃ to fully dissolve the component B, keeping the dissolving temperature constant for 30 minutes, standing, naturally cooling, and keeping the temperature constant when the temperature is reduced to 50 ℃;

s4, coating or tape-casting the preparation preserved at the constant temperature of 50 ℃ in the step 3 to form a film, dehydrating and drying the film at any temperature of 85 ℃ by adopting microwave or infrared dehydration drying equipment to form a dry film, then coating a protective film, rolling to form a film, cutting to form a shape, packaging and sealing.

Comparative example 1

Referring to fig. 1, the present invention provides the following technical solutions: a bioactive glass dressing for the restoration of human skin tissue, comprising the following raw materials: petrolatum, bioactive glass, collagen, chitosan, cocoa butter, humectants, cross-linking agents, and antioxidants.

Specifically, the composition comprises the following components in parts by weight: 60 parts of vaseline, 5 parts of bioactive glass, 5 parts of collagen, 0.2 part of chitosan, 0.05 part of cocoa butter, 2 parts of a humectant, 0.05 part of a cross-linking agent and 0.1 part of an antioxidant.

Specifically, the bioactive glass comprises the following components in parts by weight: 50% of SiO2, 5% of P2O5, 20% of Na2O and 25% of CaO, and the sum of the contents of the components is 100%.

Specifically, the chitosan is iodine chitosan

Specifically, the humectant is glycerin.

Specifically, the crosslinking agent is potassium citrate.

Specifically, the antioxidant is phenoxyethanol.

The invention also provides a preparation method of the bioactive glass dressing for restoring the skin tissues of the human body, which comprises the following steps:

s1, fully stirring and dissolving vaseline, bioactive glass, collagen and chitosan, adding cocoa seed fat, and uniformly mixing to obtain a component A;

s2, sequentially adding the humectant, the cross-linking agent and the antioxidant into the component A in the step S1, and uniformly stirring to obtain a component B;

s3, heating the component B in the step S2 to any temperature between 75 ℃ to fully dissolve the component B, keeping the dissolving temperature constant for 30 minutes, standing, naturally cooling, and keeping the temperature constant when the temperature is reduced to 50 ℃;

s4, coating or tape-casting the preparation preserved at the constant temperature of 50 ℃ in the step 3 to form a film, dehydrating and drying the film at any temperature of 25 ℃ by adopting microwave or infrared dehydration drying equipment to form a dry film, then coating a protective film, rolling to form a film, cutting to form a shape, packaging and sealing.

Through the test of figure 1, the medical and aesthetic wound healing ointment prepared by the embodiments 1 to 4 can provide a good healing environment for wound healing through the moisture tightness and good sterilization and disinfection effects of vaseline gauze, bioactive glass promotes the synthesis and secretion of collagen and epithelial growth factor, actively induces the proliferation, differentiation and migration of epithelial cells, thereby effectively promoting the wound healing, chitosan and cocoa butter are compounded, the lubrication degree of the wound can be improved, the wound is prevented from being adhered when the dressing is taken down, the wound is damaged, the moisturizing agent has a certain plasticizing effect besides moisturizing, the toughness and tensile strength of the dressing can be effectively improved, the softness after the dressing is swelled and the sticking performance to skin are vital, the swelling speed of the dressing and the dressing strength after the dressing is swelled are determined by the use of the cross-linking agent, the superior antibacterial performance of the antioxidant has good cooperative action in the system, and the bioactive glass dressing prepared by the special formula ratio can provide good healing environment for wounds, has good wound surface scar removing effect and ideal antibacterial effect.

Finally, it should be noted that: although the present invention has been described in detail with reference to the foregoing embodiments, it will be apparent to those skilled in the art that changes may be made in the embodiments and/or equivalents thereof without departing from the spirit and scope of the invention. Any modification, equivalent replacement, or improvement made within the spirit and principle of the present invention should be included in the protection scope of the present invention.

Claims (8)

1. A bioactive glass dressing for use in the restoration of human skin tissue, comprising: the method comprises the following raw materials: petrolatum, bioactive glass, collagen, chitosan, cocoa butter, humectants, cross-linking agents, and antioxidants.

2. A bioactive glass dressing for the restoration of human skin tissue as claimed in claim 1 wherein: comprises the following components by weight: 70-80 parts of vaseline, 10-20 parts of bioactive glass, 5-10 parts of collagen, 0.5-1 part of chitosan, 0.05-0.1 part of cocoa seed fat, 5-15 parts of humectant, 0.05-0.15 part of cross-linking agent and 0.1-0.2 part of antioxidant.

3. A bioactive glass dressing for the restoration of human skin tissue as claimed in claim 1 wherein: the bioactive glass comprises the following components in parts by weight: 45-50% of SiO2, 4-6% of P2O5, 20-25% of Na2O and 25-35% of CaO, wherein the sum of the contents of the components is 100%.

4. A bioactive glass dressing for the restoration of human skin tissue as claimed in claim 1 wherein: the chitosan is any one of chitosan iodine, chitosan quaternary ammonium salt or carboxymethyl chitosan.

5. A bioactive glass dressing for the restoration of human skin tissue as claimed in claim 1 wherein: the humectant is one or more of glycerol, sorbitol, butanediol, polyglycerol-10, propylene glycol and ethylhexyl glycerol.

6. A bioactive glass dressing for the restoration of human skin tissue as claimed in claim 1 wherein: the cross-linking agent is one or the combination of more of potassium citrate, calcium chloride, sodium chloride and potassium chloride.

7. A bioactive glass dressing for the restoration of human skin tissue as claimed in claim 1 wherein: the antioxidant is one or more of phenoxyethanol, methyl paraben, ethyl paraben and polylysine.

8. A method of manufacturing a bioactive glass dressing for the restoration of human skin tissue as claimed in any of claims 1 to 7 wherein: the method comprises the following steps:

s1, fully stirring and dissolving vaseline, bioactive glass, collagen and chitosan, adding cocoa seed fat, and uniformly mixing to obtain a component A;

s2, sequentially adding the humectant, the cross-linking agent and the antioxidant into the component A in the step S1, and uniformly stirring to obtain a component B;

s3, heating the component B in the step S2 to any temperature between 75 ℃ and 85 ℃ for full dissolution, keeping the dissolution temperature constant for 30 minutes, standing, naturally cooling, and keeping the temperature constant when the temperature is reduced to 50 ℃;

s4, coating or tape-casting the preparation preserved at the constant temperature of 50 ℃ in the step 3 to form a film, dehydrating and drying the film at any temperature of 25-85 ℃ by adopting microwave or infrared dehydration drying equipment to form a dry film, then coating a protective film, rolling to form a film, cutting to form a shape, packaging and sealing.

Images