CN112451649A

CN112451649A - Pharmaceutical composition for preventing and treating myopia and/or asthenopia and preparation thereof

Info

Publication number: CN112451649A
Application number: CN202011494953.XA
Authority: CN
Inventors: 孙乙文; 孙子晴
Original assignee: Xuzhou Yiwen Institute Of Traditional Chinese Medicine
Current assignee: Xuzhou Yiwen Institute Of Traditional Chinese Medicine
Priority date: 2020-12-17
Filing date: 2020-12-17
Publication date: 2021-03-09

Abstract

The invention discloses a pharmaceutical composition for preventing and treating myopia and/or asthenopia, which is characterized by being prepared from the following raw materials in parts by weight: 8-12 parts of safflower, 8-12 parts of salvia miltiorrhiza, 6-10 parts of ligusticum wallichii, 12-18 parts of white chrysanthemum, 8-12 parts of honeysuckle, 8-12 parts of coptis chinensis, 8-15 parts of green tangerine orange peel, 10-15 parts of mulberry leaves, 15-25 parts of phellinus igniarius, 15-25 parts of lucid ganoderma, 8-12 parts of wolfberry fruit, 15-25 parts of semen cuscutae, 5-12 parts of ginseng, 15-30 parts of astragalus membranaceus, 5-15 parts of semen plantaginis, 5-15 parts of semen cassiae, 5-15 parts of concha haliotidis, 5-15 parts of spina date seeds, 8-16 parts of caltrops, 6-12 parts of oysters, 8-16 parts of periostracum cicada, 5-10 parts of spirulina, 5-15 parts of sea buckthorn, 6-12 parts of ginger, 12-25 parts of placenta hominis, 4-10 parts of mint, 6-12 parts of. The medicinal composition is added with auxiliary materials acceptable for medicinal preparations, and is respectively prepared into an oral medicament and an external medicament, so that the effect of preventing and treating myopia or eye asthenopia can be achieved through oral administration or external application. The product of the invention is simple and easy to be taken orally or externally used, and can benefit more myopes, especially asthenopia patients.

Description

Pharmaceutical composition for preventing and treating myopia and/or asthenopia and preparation thereof

Technical Field

The invention belongs to the field of medicinal preparations, relates to a medicinal composition for protecting eyesight and preventing and treating eye asthenopia, and particularly relates to a medicinal composition for preventing and treating myopia and/or eye fatigue and a preparation thereof.

Background

Myopia is a common eye disease with frequently occurring diseases. Myopia diseases have various causes, such as myopia caused by poor eye use, genetic factors, application of drugs, and the like. In recent years, the incidence rate of the traditional Chinese medicine tends to rise year by year, and the incidence rate of the traditional Chinese medicine is particularly obvious. According to relevant research and report data, the incidence rate of myopia of primary school students in China is 22.8%, that of middle school students is 55.2%, that of high school students is 70.3%, that of myopia of China is 7 hundred million in 2020 is estimated by some people, and the incidence rate is nearly 51%. The myopia is caused by a plurality of reasons, such as large learning pressure, long time for bending over a desk, incorrect posture and distance during reading or writing, too strong or too weak light for reading, improper distance or too long time for watching television, unreasonable diet, genetic factors, environmental factors and the like due to long-time use of computers and mobile phones. The theory of traditional Chinese medicine considers that myopia is caused by visual deterioration due to dysfunction of viscera and meridians, loss of nourishment of eyes, stagnation of qi and blood, and blockage of the chest, such as deficiency of liver and kidney, deficiency of both qi and blood. Since the pathogenesis of myopia is still not well understood, satisfactory results in terms of prevention and treatment are still not achieved. In recent years, the incidence of myopia tends to rise year by year, and especially the incidence of myopia in young and young years is more obvious, so that medical technical workers are required to solve the problem of preventing and treating myopia of the majority of teenagers as early as possible. At present, the methods for treating myopia in the market and medical units are many, most of the methods adopt wearing glasses and health care instruments for treatment, and methods such as vision correction instruments, small-hole glasses, laser therapy, magnetic therapy, electrotherapy, acupuncture and moxibustion and the like are common. At present, some medicines, such as western medicine preparations like atropine eye drops and the like and traditional Chinese medicine preparations like polished sections and the like exist in the market, but the treatment time is long and the effect is not ideal. In severe cases, surgical treatment is mostly adopted, but the surgical treatment has great risk and more sequelae. In the formula preparations of the traditional Chinese medicine, some are mainly used for nourishing liver and kidney, some are mainly used for promoting blood circulation to remove blood stasis, some are mainly used for nourishing yin and promoting the production of body fluid, some are mainly used for dispelling wind and eliminating dampness, clearing heat and purging fire, clearing heat and relieving restlessness, and some are mainly used for tonifying middle-jiao and Qi, and the like. According to the technical scheme disclosed by the prior art, the nutritional deficiency of the eyes is mostly ignored, if the nutrition of the eyes is supplemented, the effects of dredging qi and blood, nourishing liver and kidney, balancing yin and yang, nourishing blood, soothing nerves, resisting oxidation, eliminating free radicals and providing sufficient blood oxygen are combined, so that the eyes are nourished, the asthenopia and the eye muscle spasm disappear, the vision is naturally recovered to be normal, and pseudomyopia at the beginning and middle stages, mixed myopia and astigmatism are mostly formed due to the asthenopia and the ciliary muscle spasm. With the improvement of science and technology, the pace of life and work is accelerated, the popularization of electronic products such as mobile phones, televisions and computers, the long-term use of mobile phones and computers, the long-term watching of televisions, the overnight surfing of internet for chatting and playing, the learning pressure is high, the long-term learning and writing and the like generate eye fatigue due to the excessive use of eyesight. The eye fatigue is a common disease of ophthalmology, the clinical manifestations of the eye fatigue are easy, the symptoms such as eye swelling, eye sleepiness, dryness and puckery, lacrimation, eyebrow arch ache and dizziness appear, make the short distance work or read can't last. The basic symptoms and mechanisms of asthenopia are related to the dysfunction of liver, spleen and kidney caused by various reasons. Liver yin deficiency, liver fire hyperactivity, deficiency of body fluids, and loss of luster of eyes; spleen qi deficiency, failure of ascending clear yang, failure of descending turbid yin, failure of the eyes to warm up the body of clear yang; kidney essence is insufficient and cannot pass through the brain, and brain and marrow have anxiety and essence cannot nourish eyes; physical strength is weak, people can stay in the spirit for a long time, nutrition is not constant, people can not rest due to long-term fatigue, blurred vision and even vision decline are caused, myopia is easy to cause after long-term accumulation, and life and work of people are directly influenced. Eyestrain becomes a public health and social concern for the whole society. Therefore, the traditional Chinese medicine composition in the formula is the basic guarantee for preventing and treating myopia and/or eye fatigue.

Disclosure of Invention

The invention aims to provide a pharmaceutical composition for preventing and treating myopia and/or asthenopia, which is prepared from safflower, red sage root, ligusticum wallichii, white chrysanthemum, honeysuckle flower, coptis root, green tangerine orange peel, mulberry leaf, phellinus igniarius, lucid ganoderma, wolfberry fruit, dodder seed, ginseng, astragalus root, plantain seed, cassia seed, abalone shell, spina date seed, caltrop, oyster, cicada slough, spirulina, sea buckthorn, ginger, human placenta, mint, liquorice and pearl powder through processing to prepare an oral preparation.

The invention also aims to provide a pharmaceutical composition for preventing and treating myopia and/or asthenopia, which is prepared from safflower, salvia miltiorrhiza, ligusticum wallichii, white chrysanthemum, honeysuckle, coptis chinensis, green tangerine orange peel, mulberry leaf, phellinus igniarius, lucid ganoderma, medlar, semen cuscutae, ginseng, astragalus mongholicus, semen plantaginis, semen cassiae, concha haliotidis, spina date seed, caltrop, oyster, periostracum cicada, spirulina, sea buckthorn, ginger, human placenta, liquorice, pearl powder, alum, borneol and menthol through processing.

The invention aims to promote the circulation of qi and blood, nourish liver and kidney, tonify nutrition, nourish blood and calm the nerves, provide the best medical effects of sufficient blood oxygen, antioxidation and the like, promote blood circulation, relieve eye muscle spasm, promote vasodilatation, accelerate blood flow, improve blood circulation, dredge channels and collaterals, enhance the regulation and control function, improve the eye muscle function and further obtain the good effect of preventing and treating myopia and/or eye fatigue by taking or externally using the pharmaceutical composition preparation.

In order to realize the invention, the following technical scheme is adopted:

a pharmaceutical composition for preventing and treating myopia and/or asthenopia is characterized by being prepared from the following raw materials in parts by weight: 8-12 parts of safflower, 8-12 parts of salvia miltiorrhiza, 6-10 parts of ligusticum wallichii, 12-18 parts of white chrysanthemum, 8-12 parts of honeysuckle, 8-12 parts of coptis chinensis, 8-15 parts of green tangerine orange peel, 10-15 parts of mulberry leaves, 15-25 parts of phellinus igniarius, 15-25 parts of lucid ganoderma, 8-12 parts of wolfberry fruit, 15-25 parts of semen cuscutae, 5-12 parts of ginseng, 15-30 parts of astragalus membranaceus, 5-15 parts of semen plantaginis, 5-15 parts of semen cassiae, 5-15 parts of concha haliotidis, 5-15 parts of spina date seeds, 8-16 parts of caltrops, 6-12 parts of oysters, 8-16 parts of periostracum cicada, 5-10 parts of spirulina, 5-15 parts of sea buckthorn, 6-12 parts of ginger, 12-25 parts of placenta hominis, 4-10 parts of mint, 6-12 parts of.

The invention discloses a preferable pharmaceutical composition for preventing and treating myopia and/or asthenopia, which is characterized by being prepared from the following raw materials in parts by weight: 10 parts of safflower, 10 parts of salvia miltiorrhiza, 8 parts of ligusticum wallichii, 15 parts of white chrysanthemum, 10 parts of honeysuckle, 10 parts of coptis chinensis, 12 parts of green tangerine peel, 12 parts of mulberry leaves, 20 parts of phellinus igniarius, 20 parts of lucid ganoderma, 10 parts of wolfberry, 20 parts of semen cuscutae, 8 parts of ginseng, 20 parts of astragalus membranaceus, 10 parts of semen plantaginis, 12 parts of semen cassiae, 10 parts of concha haliotidis, 10 parts of spina date seeds, 12 parts of caltrops, 9 parts of oysters, 12 parts of cicada slough, 8 parts of spirulina, 10 parts of sea-buckthorn, 8 parts of ginger, 20 parts of human placenta, 6 parts of mint, 9 parts of liquorice;

the preparation of the pharmaceutical composition comprises the following steps:

(1) respectively cleaning Saviae Miltiorrhizae radix, rhizoma Ligustici Chuanxiong, Coptidis rhizoma, pericarpium Citri Reticulatae viride, folium Mori, Phellinus Linteus, Ganoderma, fructus Lycii, semen Cuscutae, radix astragali, semen plantaginis, semen Cassiae, Concha Haliotidis, semen Ziziphi Spinosae, fructus Tribuli, Concha Ostreae, periostracum Cicadae, Spirulina, fructus Hippophae, rhizoma Zingiberis recens, and Glycyrrhrizae radix, microwave drying, and pulverizing into 40-50 mesh powder;

(2) mixing the medicinal powder obtained in step (1), moistening with edible ethanol for 40-50 hr, and adding edible ethanol at a dose of 0.3-1.5ml/kg^-1Collecting percolate at flow rate of (medicinal materials weight), stopping percolating until the percolate turns light yellow, recovering ethanol from percolate, filtering, heating and concentrating to relative density of 1.75-2.25 (50 deg.C), to obtain concentrated solution I; adding purified water 8-10 times of the weight of the medicinal materials into the percolate, decocting with strong fire for 2 hr, decocting with slow fire for 1 hr, filtering to obtain decoction, concentrating the decoction to relative density of 1.72-2.25 (50 deg.C), and collecting concentrated solution II;

(3) cleaning Carthami flos, flos Chrysanthemi, flos Lonicerae, Ginseng radix, and herba Menthae, respectively, microwave drying, grinding into 40-50 mesh powder, mixing the powders, adding edible ethanol, soaking at room temperature for 5-7 days, wherein the amount of ethanol is 5-10 times of the weight of the medicinal materials, and the soaking time is 5-7 days, mixing the three soaking solutions, recovering ethanol, filtering, and concentrating to relative density of 1.15-1.25(50 deg.C) to obtain concentrated solution III; adding purified water 5 times the weight of the medicinal materials into the soaked medicine residues, heating and decocting for 2 hours, taking the decoction, filtering, and concentrating until the relative density is 1.15-1.25(50 ℃), so as to obtain a concentrated solution IV for later use;

(4) microwave drying placenta hominis, grinding into 50 mesh powder, adding 10 times, 8 times and 5 times of normal saline, boiling and extracting for three times, wherein the boiling time is 1 hour each time, mixing the decoctions, filtering, adjusting pH of the filtrate to 3.1-3.2 with 0.1mol hydrochloric acid, standing in a refrigerator for 24-36 hours, precipitating completely, collecting supernatant, filtering, heating and concentrating the filtrate to relative density of 1.05-1.12 (50 deg.C), and collecting concentrated solution V;

(5) mixing the concentrated solutions I, II, III, IV and V obtained in the steps (2), (3) and (4), adding soluble pearl powder in parts by weight, fully and uniformly mixing to obtain a mixed concentrated solution, drying the mixed concentrated solution at low temperature until the water content is less than 5%, cooling, and crushing to obtain the pharmaceutical composition.

The pharmaceutical composition of the present invention can be prepared into oral dosage forms by adding pharmaceutically acceptable carriers during preparation of medicaments, wherein the carriers can be, but are not limited to, starch, sucrose, glucose, fructose, lactose, mannitol, syrup, honey, cellulose and derivatives thereof, propylene glycol, glycerol, polyethylene glycol, dextrin, cyclodextrin and derivatives thereof, gelatin, agar, xanthan gum, acacia gum, tragacanth gum, bletilla striata gum, surfactants, pyrrolidone, calcium carbonate, calcium bicarbonate, sodium bicarbonate, citric acid, talc, magnesium stearate, calcium stearate, etc. Such oral dosage forms include, but are not limited to: oral liquid, syrup, tablet, capsule, granule, pill, and unguent; the tablets comprise plain tablets, sugar-coated tablets, effervescent tablets and buccal tablets; the capsules comprise hard capsules and soft capsules, and the pills comprise water pills and honeyed pills.

The preparation of the invention, preferably oral dosage forms are oral liquid, tablets, capsules, granules and pills, most preferably tablets, such as effervescent tablets, and capsules, such as hard capsules.

The amount of the acceptable carrier added into the pharmaceutical composition can be properly selected according to different preparation formulations, the actual content of the pharmaceutical composition is used for marking the use amount in clinical use, for example, 1g of fine powder of the pharmaceutical composition is directly filled into a capsule or added with beta-cyclodextrin to be uniformly mixed according to a proportion and then filled into a No. 00 capsule, when the use amount is ordered, a patient can take the pharmaceutical composition according to every few capsules, but when the content is marked, the content of the extract of the traditional Chinese medicine contained in each capsule is marked to be 1g so that the patient can clearly and correctly use the extract.

The pharmaceutical composition for preventing and treating myopia and/or asthenopia of the invention has the usage and dosage as follows:

when the traditional Chinese medicine is used for treating the slight myopia, the traditional Chinese medicine is taken 2 times a day, 1g is taken each time, and the traditional Chinese medicine is taken 1 time after breakfast and supper, and 30 days is a treatment course.

When the traditional Chinese medicine is used for treating mild and moderate myopia, the traditional Chinese medicine is taken 3 times a day, 2 g each time, and 30 days as a treatment course after breakfast, lunch and supper each day.

When the eye fatigue is treated, the eye fatigue is taken 2 times a day, 2 g each time, 1 time after breakfast and supper, and 7 days are a treatment course.

The invention also aims to provide a preparation method of the pharmaceutical composition preparation for preventing and treating myopia and/or asthenopia, which is characterized by being prepared from the following raw materials in parts by weight: 8-12 parts of safflower, 8-12 parts of salvia miltiorrhiza, 6-10 parts of ligusticum wallichii, 12-18 parts of white chrysanthemum, 8-12 parts of honeysuckle, 8-12 parts of coptis chinensis, 8-15 parts of green tangerine orange peel, 10-15 parts of mulberry leaves, 15-25 parts of phellinus igniarius, 15-25 parts of lucid ganoderma, 8-12 parts of wolfberry fruit, 15-25 parts of semen cuscutae, 5-12 parts of ginseng, 15-30 parts of astragalus membranaceus, 5-15 parts of semen plantaginis, 5-15 parts of semen cassiae, 5-15 parts of concha haliotidis, 5-15 parts of spina date seeds, 8-16 parts of caltrops, 6-12 parts of oysters, 8-16 parts of periostracum cicada, 5-10 parts of spirulina, 5-15 parts of sea buckthorn, 6-12 parts of ginger, 12-25 parts of placenta hominis, 6-12 parts of liquorice, 4-8 parts of, 4-8 parts of menthol;

the invention discloses a preferable pharmaceutical composition preparation for preventing myopia and/or asthenopia, which is characterized by being prepared from the following raw materials in parts by weight: 10 parts of safflower, 10 parts of salvia miltiorrhiza, 6 parts of ligusticum wallichii, 15 parts of white chrysanthemum, 10 parts of honeysuckle, 10 parts of coptis chinensis, 12 parts of green tangerine peel, 12 parts of mulberry leaves, 20 parts of phellinus igniarius, 20 parts of lucid ganoderma, 10 parts of wolfberry, 20 parts of semen cuscutae, 8 parts of ginseng, 20 parts of astragalus membranaceus, 10 parts of semen plantaginis, 10 parts of semen cassiae, 10 parts of concha haliotidis, 10 parts of spina date seeds, 12 parts of caltrops, 9 parts of oysters, 12 parts of cicada slough, 8 parts of spirulina, 10 parts of sea-buckthorn, 8 parts of ginger, 20 parts of human placenta, 9 parts of liquorice, 6 parts of pearl powder, 6 parts of;

(1) respectively cleaning Carthami flos, Saviae Miltiorrhizae radix, rhizoma Ligustici Chuanxiong, flos Chrysanthemi, flos Lonicerae, Coptidis rhizoma, pericarpium Citri Reticulatae viride, folium Mori, Phellinus Linteus, Ganoderma, fructus Lycii, semen Cuscutae, Ginseng radix, radix astragali, semen plantaginis, semen Cassiae, Concha Haliotidis, semen Ziziphi Spinosae, fructus Tribuli, Concha Ostreae, periostracum Cicadae, Spirulina, fructus Hippophae, rhizoma Zingiberis recens, and Glycyrrhrizae radix, microwave drying, and pulverizing into 80 mesh powder; mixing the medicinal powder, and adding the medicinal powder into the mixture according to the weight ratio of 1: 10. 1: 7. 1: soaking 5V/V ethanol (30-65%) at 40-42 deg.C for three times (first 72 hr, second 48 hr, and third 24 hr) in ethanol, mixing the soaking solutions for 3 times, filtering, and recovering ethanol to obtain extractive solution;

(2) and (3) soaking the filter residue obtained in the step (1) for three times according to the weight of the medicinal materials of 1: adding purified water at a ratio of 15-20, decocting with strong fire for 3 hr, decocting with slow fire for 1 hr, filtering to obtain decoction, and concentrating to obtain concentrated solution with specific gravity of 1.15 (50 deg.C);

(3) microwave drying placenta hominis, pulverizing into 50 mesh powder, adding 10 times, 8 times and 5 times of normal saline, boiling and extracting for three times (each time for 1 hr), mixing the three decoctions, filtering, adjusting pH to 3.1-3.2 with 0.1mol hydrochloric acid, placing in refrigerator, standing at 1-2 deg.C for 24-36 hr, collecting supernatant after the solution is completely precipitated, and filtering to obtain filtrate;

(4) mixing the extract obtained in the step (1) and the concentrated solution obtained in the step (2) with the filtrate obtained in the step (3), concentrating by thin film evaporation to obtain a thick paste with the water content of 25 percent by weight, drying the thick paste in vacuum at 48-50 ℃, crushing and sieving to obtain 100-mesh powder;

(5) grinding borneol and menthol in parts by weight together, sieving the ground mixture with a 300-mesh sieve, mixing the ground mixture with water-soluble pearl powder in parts by weight, uniformly grinding the mixture, and adding the mixture into the 100-mesh powder obtained in the step (4) to be fully and uniformly blended to obtain the pharmaceutical composition.

When the pharmaceutical composition is prepared into a preparation, a pharmaceutically acceptable carrier can be added to prepare an external preparation;

the carrier can be, but is not limited to, water, ethanol, propylene glycol, polyethylene glycol, tween 80, methyl cellulose, sodium carboxymethyl cellulose, talcum powder, kaolin, vegetable oil, surfactant, glycerol, liquid paraffin, lanolin, vaseline, etc.;

the pharmaceutical composition of the present invention may be any pharmaceutical external preparation including, but not limited to, solutions, powders, suspensions, ointments, plasters, creams, sprays, patches.

The external preparation of the present invention is preferably an ointment, a spray or a patch.

Most preferred is a patch.

The external preparation can be added with pharmaceutically acceptable carriers as required to prepare formulations such as ointment, spray, paste and the like, the most preferable paste is taken as the best choice in the embodiment of the invention, the using method is simple, the operation is easy, and the external preparation has obvious effects of improving and relieving eye fatigue. The eye pasting is a new method for treating eye diseases by percutaneous absorption, the medicine is absorbed into capillary vessels through local skin and directly enters the receptor part of the target area to play a local role, however, the skin around the eye is the weakest and most sensitive part of the human skin, the medicine is easy to permeate and diffuse into the capillary vessels, small blood vessels and lymphatic vessels in the eye, and is quickly absorbed and distributed to each tissue in the eye, and the medicine is continuously released into the eye more and absorbed more because of the long retention time around the eye, the medicine concentration in the eye is higher, and the treatment effect is better.

The raw materials used in the invention have the pharmacology as follows:

the Carthami flos is dried flower of Carthamus tinctorius L of Compositae. Nature, flavor and meridian tropism: pungent and warm. It enters heart and liver meridians. Carthami flos has effects of promoting blood circulation, dredging channels, removing blood stasis and relieving pain. It is commonly used for amenorrhea, dysmenorrhea, lochiorrhea, mass, chest stuffiness, cardialgia, abdominal pain due to stasis, stabbing pain in chest and hypochondrium, traumatic injury, sore and ulcer with swelling and pain. Safflower enters heart and liver meridian and blood system, has the property of pungent, cool and unblocking, functions of promoting blood circulation and unblocking meridians, dissipating blood stasis and alleviating pain, is the essential herb for promoting blood circulation and removing blood stasis, and is also good at promoting blood circulation and removing blood stasis, and eliminating mass and dissipating stagnation, and is also commonly used for mass and abdominal mass caused by stasis (pharmacopoeia of the people's republic of China, clinical medication need, Chinese medicinal tablet roll, 2015 version 843P).

The Saviae Miltiorrhizae radix is dried root and rhizome of Salvia milirhizorrhiza bge. Bitter and slightly cold in nature. It enters heart and liver meridians. The salvia miltiorrhiza has the functions of activating blood and dissolving stasis, stimulating the menstrual flow and relieving pain, clearing away the heart fire and relieving restlessness, cooling blood and eliminating carbuncle. Can be used for treating thoracic obstruction, cardialgia, abdominal pain, hypochondriac pain, abdominal mass, pain due to pyretic arthralgia, vexation, insomnia, menoxenia, dysmenorrhea, amenorrhea, and pyocutaneous disease with swelling and pain. Salvia miltiorrhiza, which is bitter in taste and cool in nature, enters heart and liver meridians and enters blood system mainly, has the functions of activating blood and removing stasis, has a wide application range and is suitable for various syndromes caused by blood stasis obstruction. Salvia miltiorrhiza has the functions of cooling blood heat, clearing heart fire and calming the mind. Is suitable for hyperpyrexia and coma caused by heat entering nutrient-blood, and uneasiness and palpitation and insomnia caused by blood failing to nourish heart (pharmacopoeia of people's republic of China, clinical medication palpation, Chinese medicinal tablet roll, 2015 version 836P).

The rhizoma Ligustici Chuanxiong is dried rhizome of Ligusticum chuanxiong Hort of Umbelliferae. Chuan Xiong is pungent in flavor and warm in nature. It enters liver, gallbladder and pericardium meridians. Has the functions of promoting blood circulation, promoting qi circulation, dispelling pathogenic wind and relieving pain. Can be used for treating thoracic obstruction, cardialgia, stabbing pain in chest and hypochondrium, traumatic injury, menoxenia, amenorrhea, dysmenorrhea, abdominal mass, headache, and rheumatalgia. Chuan Xiong is pungent and warm in property and has the actions of activating blood and moving qi, so it is called as "blood-qi-flowing-in-blood-qi-flowing medicine" (the book Cao Hui Yan). It can promote blood circulation, remove blood stasis, dredge collaterals, and treat heart meridian obstruction, thoracic obstruction, and cardiodynia; it is also indicated for chest and hypochondrium stabbing pain due to liver qi stagnation, because it can move qi, relieve qi stagnation and alleviate pain. It is also indicated for abdominal mass and pain, and has the actions of activating blood and resolving stasis, and eliminating mass and dissipating nodulation. Chuan Xiong can also activate blood and dissipate blood stasis, resolve swelling and alleviate pain, and is commonly used for traumatic injuries and pain caused by stasis. Chuan Xiong Xin san has the functions of dispelling wind, promoting blood circulation and removing blood stasis, and bypassing collaterals (pharmacopoeia of the people's republic of China, clinical medication palpation, volume of Chinese medicinal decoction, 2015 version 811P).

The white chrysanthemum is also called chrysanthemum, chamomile, chrysanthemum morifolium, Huai chrysanthemum, tea chrysanthemum and chrysanthemum. The chrysanthemum is divided into yellow chrysanthemum and white chrysanthemum. Generally, Huang Ju Hua is used for dispelling wind-heat, Bai Ju Hua is suitable for pacifying liver, clearing liver and improving vision, so the Ju Hua adopted in the invention is Bai Ju Hua. The flos Chrysanthemi is dried head-like inflorescence of Chrysanthemum morifolium Ramat. Chrysanthemum is sweet, bitter and slightly cold in nature and taste. It enters lung and liver meridians. Has the functions of dispelling wind, clearing heat, calming liver, improving eyesight, clearing heat and detoxicating. Can be used for treating wind-heat type common cold, headache, giddiness, conjunctival congestion, swelling and pain, dim eyesight, sore, carbuncle, and toxic swelling. The chrysanthemum can disperse wind-heat in lung meridian but has weak power of dispersing exterior pathogen. Chrysanthemum is slightly cold in nature and enters liver meridian to clear liver heat and calm liver yang, so it is commonly indicated for liver yang hyperactivity, headache and vertigo. Chrysanthemum is light in weight, slightly bitter in taste and capable of releasing heat, slightly cold in nature and clearing heat, enters liver meridian, and can disperse liver meridian wind-heat and clear liver heat to improve vision, so it can be used for treating conjunctival congestion and swelling pain caused by liver meridian wind-heat or liver fire attacking upwards. For deficiency of essence and blood of liver and kidney, blurred vision, it is often combined with liver and kidney-nourishing, yin-tonifying and vision-improving herbs (pharmacopoeia of the people's republic of China, clinical medicine need to know, volume of Chinese medicine tablets, 2015 edition 129-130P).

The flos Lonicerae is dried bud or flower with initial bloom of Lonicera japonica Thunb. Honeysuckle flower is sweet in nature and taste and cold in nature. It enters lung, heart and stomach meridians. Has the functions of clearing away heat and toxic material and dispelling wind and heat. Can be used for treating carbuncle, furuncle, sore throat, erysipelas, toxic heat, dysentery, wind-heat type common cold, epidemic febrile disease, and fever. Honeysuckle flower is sweet in taste and cold in nature, fragrant in smell, and mild in drug property, enters lung, heart and stomach meridians, clears heat without damaging qi, and dissolves toxin without damaging yin, is good at clearing qi and dividing heat evil, penetrating nutrient and activating qi, relieving fire toxin, eliminating carbuncle and swelling, and has strong effects of clearing heat and removing toxicity, and is an essential drug for treating pyocutaneous disease. It is commonly indicated for abscess, deep-rooted boil, sore throat, erysipelas and other heat-toxin syndromes. It is also a good herb for wind-heat type common cold, epidemic febrile disease and fever because it can disperse the wind, disperse the pathogenic heat in lung channel and expel the pathogenic heat from the exterior. For heat entering nutrient-blood, crimson tongue with coma, restlessness and insomnia, it also has the effect of transforming nutrient-qi (pharmacopoeia of the people's republic of China-clinical application of medicine, volume of decoction of Chinese herbs, version 235P 2015).

The Coptidis rhizoma is dried rhizome of Coptis chinensis Franch, Coptis deltoidea C.Y.Cheng et Hsiao or Coptis Teeta wall of Ranunculaceae. Huang Lian is bitter in flavor and cold in nature. It enters heart, spleen, stomach, liver, gallbladder and large intestine meridians. Has the functions of clearing heat, drying dampness, purging fire and detoxifying. Can be used for treating damp-heat distention and fullness, emesis, acid regurgitation, dysentery, jaundice, hyperpyrexia, excessive heart-fire, vexation, insomnia, palpitation, hematemesis, epistaxis, conjunctival congestion, toothache, diabetes, carbuncle, swelling, and furuncle. Coptis root, rhizoma Coptidis, being bitter and cold, enters liver meridian and clears liver fire, can be used for vomiting and acid regurgitation due to liver depression transforming into fire and transverse adverse flow affecting stomach. Coptis root, rhizoma Coptidis, having the actions of clearing heat and drying dampness, purging fire and removing toxicity, excels in treating furunculosis, and is commonly indicated for exuberant heat-toxicity, red and swollen eyes, sores in the mouth and tongue, carbuncle and furuncle (pharmacopoeia of the people's republic of China, clinical medication palpation, volume of Chinese medicinal decoction, 2015 version 195P).

The pericarpium Citri Reticulatae viride is pericarp of dried young fruit or immature fruit of Citrus reticulata Blanco of Rutaceae and its cultivar. Qing Pi is bitter and pungent in flavor and warm in nature. It enters liver, gallbladder and stomach meridians. Has the functions of soothing liver, breaking qi, removing food retention and resolving stagnation. Can be used for treating distending pain in chest and hypochondrium, hernia pain, nodules of breast, mammary abscess, food stagnation, qi stagnation, and abdominal pain. Qing Pi is pungent and warm in property, bitter in flavor and purgative in descending, and drastic in property, and is a herb of qi system of liver and gallbladder, and has the actions of dispersing stagnated liver qi and gallbladder, breaking qi stagnation, dissipating nodulation and relieving pain, so it is especially suitable for treating distending pain in chest and hypochondrium, hernia pain, and swelling and pain in breast caused by liver depression and qi stagnation (pharmacopoeia of the people's republic of China, clinical palpation of medicine, Chinese medicinal decoction roll, 2015 edition P672).

The folium Mori is dry leaf of Morus alba L. Mulberry leaves are sweet, bitter and cold in nature and taste. It enters lung and liver meridians. Has the functions of dispelling wind and heat, clearing away lung heat, moistening dryness, clearing liver and improving vision. Can be used for treating wind-heat type common cold, lung heat type cough, dizziness, headache, conjunctival congestion, and dim eyesight. Mulberry leaf, folium Mori is bitter and cold, enters liver meridian, and has the action of pacifying and descending liver yang, so it can be used for treating hyperactivity of liver yang, headache, vertigo, heaviness of head, light feet, restlessness and irritability. Mulberry leaf, folium Mori, being bitter and cold in property, can clear heat from the liver channel, clear liver heat, and nourish yin to improve vision, so it is commonly indicated for conjunctival congestion, pain and lacrimation due to wind-heat attacking the upper part of the body and up-flaming of liver fire. For deficiency of liver and kidney essence and blood, blurred vision, it is often combined with essence and blood tonics (pharmacopoeia of the people's republic of China, clinical palpation, volume of Chinese medicinal tablets, 2015 version 127P).

Phellinus linteus, also called Phellinus linteus and Phellinus linteus, is the fruiting body of Phellinus linteus Phellinus igniarius (L.ex Fr.) Quel. Phellinus Linteus is sweet, pungent, bitter and cold in nature. It enters liver and kidney meridians. Has effects in promoting blood circulation, stopping bleeding, resolving phlegm, and relieving diarrhea. It is suitable for metrorrhagia, stranguria with blood, diarrhea, rectocele, leukorrhagia, amenorrhea, abdominal mass, diarrhea due to spleen deficiency. The literature states that: phellinus linteus is rich in flavonoids such as naringenin, sakuranetin, and eriodictyol; coumarin components such as coumarins and hyoscyamine; also contains agaricic acid, veratrine, mushroom acid, ergosterol, amino acid, etc. The pharmacology of the liver-protecting drug has the liver-protecting effect: phellinus igniarius is capable of obviously relieving degeneration and necrosis of liver cells, maintaining normal structure of liver tissues and promoting recovery of liver functions; scavenging free radicals: phellinus igniarius intracellular polysaccharide can increase the defense function of organism against free radical injury (Wang Guo Qiang compiled "national Chinese herbal medicine Association" volume three, national health Press, 3 rd edition 2 month 2014, 515P).

Ganoderma is dried fruiting body of Ganoderma Lucidum Canoderma Lucidum (Leys. ex Fr.) Karst. or Ganoderma sinense Zhao, Xu et Zhang. Ganoderma lucidum is sweet in nature and mild in flavor. It enters heart, lung, liver and kidney meridians. Has the functions of invigorating qi, tranquilizing, relieving cough and asthma. Can be used for treating restlessness, insomnia, palpitation, cough due to lung deficiency, asthenia, short breath, and anorexia. Ganoderma lucidum is sweet in flavor and can tonify heart qi and calm heart spirit, so it can be used for treating unsteadiness of heart-mind, insomnia, palpitation due to malnutrition of heart-spirit. Ganoderma enters lung and kidney meridians to tonify qi of lung and kidney, and can relieve cough and dyspnea, so it is often indicated for cough and dyspnea due to lung deficiency, shortness of breath due to asthenia, poor appetite, etc. Ganoderma has tranquilizing, antiepileptic, brain tissue protecting, immunity enhancing, antitumor, liver protecting, blood sugar lowering, diabetes complication inhibiting, antiaging, blood lipid reducing, atherosclerosis resisting, and kidney protecting effects (pharmacopoeia of people's republic of China, clinical application requires knowledge, Chinese medicinal tablet roll, 2015 edition 1004-1005P). The literature also discloses: from the 70 s of the 20 th century, more than 20 national medical research units such as Beijing medical college, Chinese medical academy of sciences, Beijing institute of pharmacy, Sichuan institute of antibiotics, Shanghai medical university, etc. have systematically developed the researches on the pharmacology, pharmacological action, and curative effect of Ganoderma lucidum in succession, and many effects of Ganoderma lucidum are clarified and known in depth. The research result shows that: the ganoderma lucidum has various pharmacological activities and curative effects, and has the effects of improving the organism immunity, inhibiting the growth of tumors, improving myocardial contractility, accelerating blood circulation, improving blood microcirculation, improving hemoglobin oxygen carrying and supplying, expanding arteriovenous oxygen difference, calming the liver, detoxifying, improving the organism physiological function, reducing blood pressure, blood fat and blood sugar, calming the nerves, relieving spasm and blood viscosity. The efficacy of Ganoderma lucidum recorded in Shennong Ben Cao Jing (Shen nong's herbal Jing) has been fully proven (Chen Guo Liang, Chen Hui Shu (Ganoderma lucidum treating diseases), third edition, Shanghai science and technology literature Press, 2007, 4 months, page 4).

Fructus Lycii is dried mature fruit of Lycium barbarum L. Wolfberry fruit is sweet in nature and mild in taste. It enters liver and kidney meridians. Has effects in nourishing liver and kidney, replenishing vital essence, and improving eyesight, and can be used for treating asthenia essence deficiency, soreness of waist and knees, vertigo, tinnitus, sexual impotence, spermatorrhea, internal heat, diabetes, blood deficiency, sallow complexion, and blurred vision. Wolfberry fruit, fructus Lycii, sweet in taste and neutral in nature, enters liver and kidney meridians, excels in nourishing kidney essence and tonifying liver blood, and is said in Ben Cao Jing Shu (materia Medica of materia Medica): "is the essential herb for fatigue, internal heat and invigoration due to deficiency of liver and kidney yin, and can be used for treating soreness and weakness of waist and knees, vertigo, tinnitus, spermatorrhea, infertility and blurred vision caused by deficiency of liver and kidney essence and blood (pharmacopoeia of the people's republic of China, clinical medication need, volume of traditional Chinese medicine tablets, 2015 edition 1230P).

Semen Cuscutae is dried mature seed of south semen Cuscutae Cuscuta australis R.Br. or semen Cuscutae Cuscuta chinensis Lam. The dodder seed is pungent, sweet and mild in nature. It enters liver, kidney and spleen meridians. Has the effects of tonifying liver and kidney, securing essence, reducing urination, preventing miscarriage, improving eyesight and stopping diarrhea. Can be used for treating kidney deficiency, soreness of waist and knees, sexual impotence, spermatorrhea, enuresis, frequent micturition, fetal leakage due to kidney deficiency, fetal irritability, blurred vision, tinnitus, and spleen and kidney deficiency. The dodder seed is pungent and sweet and neutral, enters liver, kidney and spleen channels, can moisten and tonify in sweet, has mild property, can tonify kidney yang and kidney yin, is a product for tonifying yin and yang, has the functions of tonifying liver and kidney, securing essence and reducing urination, and is used for treating liver and kidney deficiency and soreness and weakness of waist and knees; dodder seed, semen Cuscutae, also has the actions of tonifying kidney and liver, promoting the injection of essence and blood to improve vision and hearing, so it is indicated for blurred vision and tinnitus due to liver and kidney deficiency (pharmacopoeia of the people's republic of China, clinical medicine palpation, volume of Chinese medicinal tablets, 2015 th edition 1163P).

Ginseng radix is dried root and rhizome of Panax ginseng C.A.Mey. Ginseng is sweet in nature, slightly bitter in taste and slightly warm in nature. It enters spleen, lung, heart and kidney meridians. Has effects of invigorating primordial qi, restoring pulse, relieving depletion, invigorating spleen, benefiting lung, promoting fluid production, nourishing blood, tranquilizing mind, and improving intelligence. Can be used for treating asthenia, collapse, cold limbs, weak pulse, spleen deficiency, anorexia, lung deficiency, cough, asthma, body fluid deficiency, thirst, internal heat, diabetes, deficiency of both qi and blood, asthenia, palpitation, insomnia, sexual impotence, and cold womb. Ginseng, sweet in taste, slightly bitter and warm in nature, mainly enters spleen, lung, heart and kidney meridians. It has a wide range of qi tonics, and can tonify both original qi and lung qi, spleen qi, heart qi and kidney qi, and its action of tonifying original qi, restoring pulse and relieving depletion can not be substituted by any drug, so it is the essential drug for saving critical depletion. Ginseng radix has effects of invigorating primordial qi, nourishing heart-qi, tranquilizing mind, improving intelligence, and tranquilizing mind, and can be used for treating insomnia and amnesia due to heart-qi deficiency or deficiency of heart-kidney qi and deficiency of both heart and spleen. Ginseng, sweet and warm in taste, has the effects of invigorating primordial qi and replenishing qi to produce blood, and has the effect of tonifying both qi and blood, so it can be used for treating spleen and stomach qi deficiency, deficiency of source of transformation, and sallow complexion due to blood deficiency; it can also tonify qi to strengthen yang, so it is indicated for deficiency of primordial qi, decline of vital gate fire, impotence and cold womb. In a word, the action of ren Shen is mainly to tonify primordial qi, lung qi, spleen qi, heart qi, kidney qi, promote fluid production, induce tranquilization and benefit intelligence, so it is the first herb for consumptive disease internal injury (pharmacopoeia of people's republic of China, clinical medication need, volume of Chinese medicinal tablets, 2015 edition 1079P).

The radix astragali is dried root of Astragalus membranaceus (Fisch.) Bge. of Leguminosae family or Astragalus membranaceus (Fisch.) Bge. of Hsiao. Astragalus root, radix astragali is sweet in nature and taste, and is slightly warm. It enters liver and spleen meridians. Has the functions of invigorating qi, invigorating yang, consolidating superficial resistance, arresting sweating, inducing diuresis, relieving swelling, promoting fluid production, nourishing blood, activating stagnancy, relieving arthralgia, expelling toxin, expelling pus, healing sore and promoting granulation. Can be used for treating deficiency of vital energy, asthenia, anorexia, loose stool, collapse of middle-warmer energy, chronic diarrhea, rectocele, hematochezia, spontaneous perspiration due to exterior deficiency, edema due to qi deficiency, internal heat, diabetes, blood deficiency, hemiplegia, arthralgia, numbness, carbuncle, cellulitis, and intractable ulcer. Huang Qi is sweet and warm in taste, enters spleen meridian and is good at tonifying spleen qi and lifting middle-jiao yang, so it is the most suitable for deficiency of middle-jiao qi, weakness of spleen and earth and sinking of clear qi (Ben Cao Zheng Yi). Astragalus root, radix astragali, being sweet and slightly warm, has the functions of tonifying qi and raising yang, promoting yin growth by covering yang, and promoting qi and blood generation, so it has the functions of tonifying qi and generating blood, and is commonly used for treating internal injury due to overstrain, deficiency of qi and blood, blood deficiency and yang floating, muscle heat and red face, blood deficiency and fever due to large and weak pulse, and excessive thinking, overstrain, heart and spleen injury due to overstrain, deficiency of both qi and blood, sallow complexion, palpitation and insomnia. Qi moving and blood moving, qi stagnation and blood coagulation, astragalus root has the action of tonifying qi and qi moving (pharmacopoeia of the people's republic of China, clinical medication palpation, volume of Chinese medicinal tablets, 2015 edition 1093P).

Plantago asiatica L or Plantago depressa Willd dried mature seeds of Plantago asiatica L. Plantain seed, semen plantaginis is sweet in nature and cold in flavor. It enters liver, kidney, lung and small intestine meridians. Has effects in clearing away heat, promoting urination, treating stranguria, eliminating dampness, relieving diarrhea, improving eyesight, and eliminating phlegm. Can be used for treating pyretic stranguria, pain, edema, swelling, summer-heat dampness, diarrhea, conjunctival congestion, swelling and pain, and cough due to phlegm-heat. Che Qian Zi is sweet and bland in flavor and good at excreting dampness and heat, clearing heat and promoting the flow of qi and cold, and directing dampness and heat downward and flowing out of urine. Edema, fullness and distention due to damp-heat accumulation in the interior, difficult urination, etc. It is especially suitable for treating stranguria due to downward flow of damp-heat. Che Qian Zi enters small intestine meridian and can excrete clear and turbid urine and induce diuresis to make stool solid. So it is indicated for summer-heat-damp diarrhea due to difficulty in urination caused by dampness in large intestine. Che Qian Zi enters liver and passes kidney, so it can clear liver heat and improve vision, so it is indicated for blood-shot eyes with swelling and pain. Che Qian Zi enters lung meridian and can clear lung heat, resolve phlegm turbidity and relieve cough, so it is indicated for cough with profuse phlegm due to lung heat (pharmacopoeia of people's republic of China, clinical need for medication, volume of Chinese medicinal tablets, 567P 2015).

The semen Cassiae is dried mature seed of Cassia obtusifolia L. or Cassia tora L. of Leguminosae. Cassia seed, semen Cassiae, is sweet, bitter, salty and slightly cold in nature and taste. It enters liver and large intestine meridians. Has the functions of clearing away heat, improving eyesight, moistening intestine and relaxing bowels. Can be used for treating conjunctival congestion, photophobia, lacrimation, headache, vertigo, dim eyesight, and constipation. Cassia seed, semen Cassiae, bitter in flavor and cold in property, can clear heat and nourish yin, not only can clear liver fire, but also can nourish liver yin, is a good product for improving eyesight, and can be applied to both deficiency and excess eye diseases. Shen nong Ben Cao Jing carries its feature of treating blindness, eye irritability, red and white membrane, red and painful eyes and lacrimation, so it is commonly indicated for conjunctival congestion, painful eyes, photophobia and lacrimation caused by wind-heat attacking upwards; conjunctival congestion and swelling pain due to up-disturbance of liver fire, headache and vertigo, and blurred vision due to yin deficiency of liver and kidney (pharmacopoeia of the people's republic of China, clinical need for medicine, volume of Chinese medicinal tablets, 2015 version 177 and 178P).

The Concha Haliotidis is shell of Haliotis diversicolor Reeve, Haliotis discus hannai Ino, Haliotis ovirina Gmelin, Haliotis asini ruber (Leach), Haliotis asini Linnaeus or Haliotis laevigata (Donovan) of Haliotis pall. Shi Jue Ming is salty in flavor and cold in nature. It enters liver meridian. Has the functions of calming the liver, suppressing yang hyperactivity, clearing liver and improving vision. Can be used for treating headache, vertigo, conjunctival congestion, nebula, blurred vision, and night blindness. Shi Jue Ming enters liver meridian due to salty cold and sinking property, excels in descending liver yang and clearing liver heat and tonifying liver yin, so it is the essential herb for cooling liver and relieving liver in Yi Xue Zhong xi Lu, so it is good at treating headache and vertigo due to liver yang hyperactivity caused by yin deficiency and deficiency of liver and kidney. Shi Jue Ming can clear liver fire, benefit liver yin to improve vision and remove nebula, is a common product for clearing liver and improving vision, and can be used for treating red eyes, swelling and pain, nebula, blurred vision, and other symptoms, no matter deficiency or excess, so it is the essential herb for treating eye diseases; it is also indicated for blood-shot eyes with swelling and pain due to up-flaming of liver fire because of its strong action of clearing liver fire (pharmacopoeia of the people's republic of China, clinical need for medication, volume of Chinese medicinal tablets, 2015 version 1021P).

The semen Ziziphi Spinosae is dry mature seed of Ziziphus jujuba Mill.var. spinosa (Bunge) Hu ex H.F.Chou belonging to Rhamnaceae. Suan Zao ren is sweet, sour and mild in nature. It enters liver, gallbladder and heart meridians. Has the functions of nourishing heart, tonifying liver, calming heart, tranquilizing mind, arresting sweating and promoting the production of body fluid. Can be used for treating vexation, insomnia, palpitation, dreaminess, asthenia, hyperhidrosis, body fluid deficiency, and thirst. The spina date seed is sweet in taste and capable of tonifying, enters liver and heart meridians, has the effects of nourishing heart yin and benefiting liver blood to calm heart and tranquilize mind, is an essential heart-nourishing and tranquilization medicine and is mainly used for treating palpitation, vexation and insomnia, dreaminess and the like caused by insufficient heart-liver yin blood, heart failure and mental retardation (the pharmacopoeia of the people's republic of China, clinical medication need, a traditional Chinese medicine tablet roll, 2015 version 1000-plus 1001P).

The fructus Tribuli is dried mature fruit of Tribuli terrestris L. The caltrop is pungent, bitter and slightly warm in nature; has little toxicity. It enters liver meridian. Has effects in calming liver, relieving depression, promoting blood circulation, expelling pathogenic wind, improving eyesight, and relieving itching. Can be used for treating headache, vertigo, distending pain in chest and hypochondrium, milk retention, mammary abscess, conjunctival congestion, nebula, rubella and pruritus. Tribulus terrestris, bitter in flavor and descending in order to enter liver meridian, has the action of pacifying liver yang, so it can be used to treat hyperactivity of liver yang, headache and vertigo. Tribulus terrestris is pungent in flavor and capable of dispersing and good at dispelling wind-heat in liver channel to improve vision and remove nebula, and is an essential herb for treating wind-heat and improving vision in the book Jing Yuan (pharmacopoeia of the people's republic of China, clinical medicine need know, volume of Chinese medicinal tablets, version 1029 of 2015, 1030P).

The Concha Ostreae is the shell of Ostrea gigas Thunberg, Ostrea talienhanensis Crosse or Ostrea rivularis Gould of Ostrea gigas of Ostrea. Oyster is salty in flavor and slightly cold in nature. It enters liver, gallbladder and kidney meridians. Has the functions of tranquilizing, subduing yang, nourishing yin, softening hardness and dissipating stagnation. It is used for treating palpitation, insomnia, vertigo, tinnitus, scrofula, phlegm nodule, abdominal mass, etc. Oyster is salty and cold in nature, enters liver and kidney, astringes soul, relieves convulsion and tranquilizes, so it is indicated for restlessness, palpitation and insomnia. Oyster has the functions of calming liver and suppressing yang, nourishing yin and clearing heat due to the accumulation of salty cold and sinking of the liver and kidney meridians, and is mainly used for treating dizziness, dysphoria, tinnitus and other symptoms caused by water retention, yin deficiency and yang hyperactivity (pharmacopoeia of the people's republic of China, clinical medication need, traditional Chinese medicine decoction, 2015 version 1024P).

The periostracum Cicadae is peel shell of Cryptotympana pustulata Fabricius of cicadae insect when nymph emergence. Cicada slough is sweet in nature and cold in flavor. It enters lung and liver meridians. Has effects in dispelling pathogenic wind and heat, relieving sore throat, promoting eruption, improving eyesight, removing nebula, and relieving spasm. Can be used for treating wind-heat type common cold, pharyngalgia, hoarseness, measles without adequate eruption, rubella, pruritus, conjunctival congestion, nebula, convulsion, and tetanus. Chan tui enters liver meridian and is good at dispelling wind-heat from liver meridian and improving vision and removing nebula, so it is indicated for blood-shot eyes with swelling pain and nebula covering eyes due to wind-heat attacking or liver fire flaming up. In addition, it has the actions of tranquilizing and allaying excitement (pharmacopoeia of the people's republic of China, clinical medication need, volume of Chinese medicinal tablets, 2015 edition 125P).

The Spirulina is dried body of Spirulina platensis (Nords) Geitlerr of Spirulina of Oscillatoriaceae. Spirulina is salty, sweet and mild in nature and taste. It enters liver, spleen and kidney meridians. Has the functions of benefiting qi, nourishing blood, invigorating spleen and tonifying kidney. Is suitable for adjuvant treatment of asthenia, malnutrition, anemia, leukopenia, platelet decrease, hyperlipidemia, and hypoimmunity caused by tumor chemotherapy and radiotherapy. The spirulina contains protein and polysaccharide, and the protein mainly comprises isoleucine, leucine, lysine, methionine, phenylalanine, threonine, tryptophan, valine and the like. In addition, the beverage also contains fat, chlorophyll, carotenoid, phycocyanin, vitamin A, B1, B2, B6, B12, E, nicotinic acid, creatine, r-linolenic acid, calcium pantothenate, folic acid, calcium, iron, zinc, magnesium and the like (Wang Qiang's Ming Shui (national Chinese herbal medicine assembly), volume three, people's health Press, 3 rd edition 2 month 2014, 669-. The spirulina contains abundant nutrient components and contains vitamin E which is richer than malt, and a plurality of clinical trials prove that the vitamin E has the functions of resisting oxidation, aging and cancers, and can enhance the immunity and prevent the formation of blood clots. The spirulina contains various physiological active components, such as polysaccharide, phycocyanin, vitamin, beta-carotene, gamma-linolenic acid (GLA) and some enzymes, so that the spirulina has various health care functions of anti-aging, effective elimination of in-vivo free radicals, anti-fatigue, antivirus and the like (Zhang Lianfu, Ji hongwu mainly compiles 'resources and bioactive components for both medicine and food', chemical industry press, 9 th edition 2005, 256-plus 260P).

The fructus Hippophae is dried mature fruit of Hippophae rhamnoides L. Seabuckthorn is sour, astringent and warm in nature. It enters spleen, stomach, lung and heart meridians. Has the functions of invigorating spleen, promoting digestion, relieving cough, eliminating phlegm, promoting blood circulation and removing blood stasis. Can be used for treating spleen deficiency, anorexia, abdominal pain due to dyspepsia, cough with excessive phlegm, thoracic obstruction, cardialgia, blood stasis, amenorrhea, and traumatic injury with blood stasis and swelling. Seabuckthorn fruit enters heart meridian, has the functions of activating blood circulation and removing blood stasis, and can be used for treating various blood stasis syndromes such as thoracic obstruction, cardiodynia, traumatic injury, irregular menstruation and the like. It is more effective in activating blood and dredging collaterals, so it is used for chest impediment, stasis and pain (pharmacopoeia of the people's republic of China, clinical medication need, volume of decoction of Chinese herbs, 1121P 2015 version).

The rhizoma Zingiberis recens is fresh rhizome of Zingiber officinale Rosc. Ginger is pungent in nature and slightly warm in taste. It enters lung, spleen and stomach meridians. Has effects in relieving exterior syndrome, dispelling cold, warming middle warmer, relieving vomit, eliminating phlegm, relieving cough, and removing toxic materials of fish, and can be used for treating wind-cold type common cold, stomach cold type emesis, cough due to cold phlegm, and fish chelate poisoning. The pharmacology is as follows: has antipyretic, analgesic, antiinflammatory, immunosuppressive, antiemetic, gastric mucosa protecting, tranquilizing, anticonvulsive, cardiovascular system affecting, antibacterial, and antioxidant effects (pharmacopoeia of the people's republic of China, clinical application, decoction of Chinese medicinal materials, 2015 edition 85-87P).

Placenta hominis is the dried placenta of healthy people. Placenta hominis is sweet, salty and warm in nature. It enters lung, liver and kidney meridians. Has the functions of warming kidney, replenishing essence, benefiting qi and nourishing blood. Can be used for treating asthenia, marasmus, sexual impotence, spermatorrhea, infertility, olignosis, chronic cough, asthma, hectic fever, cough, sallow complexion, anorexia, and short breath. Human placenta is a product with blood and meat emotion, is surplus from pregnancy caused by essence and blood, is sweet and salty in nature and warm, enters the three channels of lung and liver and kidney, controls qi in the lung, stores blood in the liver and stores essence in the kidney, and is a product for warming the kidney, replenishing essence, tonifying qi and nourishing blood; placenta hominis has the effects of tonifying lung qi and replenishing essence and blood, and is commonly indicated for deficiency of both lung and kidney (pharmacopoeia of the people's republic of China, clinical medication palpation, volume of decoction of Chinese medicinal herbs, 2015 edition 1179P).

The herba Menthae is dried aerial part of Mentha haplocalyx Briq. The mint is pungent in flavor and cool. It enters lung and liver meridians. Has effects in dispelling pathogenic wind and heat, refreshing mind, relieving sore throat, promoting eruption, dispersing stagnated liver qi, and promoting qi circulation. Can be used for treating wind-heat type common cold, headache, conjunctival congestion, pharyngitis, aphtha, rubella, measles, and chest and hypochondrium swelling. Mint is light in weight, fragrant and floating, and has the effects of dredging orifices, dispelling wind-heat from upper jiao, refreshing head and eyes, and relieving sore throat, so it can be used for treating headache, vertigo, conjunctival congestion, lacrimation, sore throat, and aphtha of mouth and tongue caused by wind-heat attacking upwards. Mint enters liver meridian and can soothe liver and promote qi circulation; therefore, it can be used for treating liver qi stagnation (pharmacopoeia of the people's republic of China, clinical medication need, volume of decoction of Chinese medicinal herbs, 120P 2015 edition).

The Glycyrrhrizae radix is dried root and rhizome of Glycyrrhiza uralensis Fisch, Glycyrrhiza inflata Bat, or Glycyrrhiza glabra L. Licorice root, radix Glycyrrhizae is sweet in nature and taste, and mild in nature and flavor. It enters heart, lung, spleen and stomach meridians. Has the effects of invigorating spleen and replenishing qi, clearing away heat and toxic materials, eliminating phlegm and relieving cough, relieving spasm and pain, and harmonizing the medicines. Can be used for treating weakness of spleen and stomach, asthenia, palpitation, short breath, cough, excessive phlegm, abdominal and limb spasm, pain, carbuncle, swelling, sore, and drug toxicity and strong nature. The liquorice is sweet in taste and neutral in nature and enters heart, lung, spleen and stomach meridians; it is good at tonifying heart qi, promoting blood circulation, and restoring pulse, and can be used for treating heart qi deficiency, palpitation, and intermittent pulse; licorice root, radix Glycyrrhizae is sweet in flavor and slightly cold in nature, can clear away heat and toxic materials, and is commonly used for treating sore throat, carbuncle, swelling, sore and other diseases. Licorice root also has the action of moderating the property of herbs and harmonizing the herbs. Besides relieving the toxicity of the medicine, it can also be used for regulating the bias of cold and heat, the severity and the taste of the medicine (pharmacopoeia of the people's republic of China, clinical medication need know, Chinese medicine decoction pieces roll, 1105P of 2015 edition).

The Margarita is prepared from bivalve animals such as Pteria martensii (Dunker), Hyriopsis cumingii (Lea), or Cristaria plicata (Leach). Pearl is sweet, salty and cold in nature and taste. It enters heart and liver meridians. Has the functions of calming the nerves, arresting convulsion, improving eyesight, removing nebula, detoxifying, promoting granulation, moistening skin and removing speckles. Can be used for treating pavor, insomnia, infantile convulsion, epilepsy, conjunctival congestion, nebula, unhealing sore and ulcer, and skin mottle. Pearl is salty and cold, heavy and heavy in nature, enters heart and liver meridians, and can be used for tranquilizing mind and arresting convulsion, and is mainly indicated for unsteadiness of heart-mind, palpitation and insomnia. Because of its cold nature, clearing heat, sweet and cold property, benefiting yin, it is indicated for restlessness, insomnia, dreaminess, amnesia, restlessness due to heart yin deficiency with heat. Pearl has the effects of clearing liver heat, improving eyesight and removing nebula when entering liver channel, so it can be used for treating various eye diseases such as conjunctival congestion, pain and nebula generation caused by wind heat in liver channel or liver fire (pharmacopoeia of the people's republic of China, clinical medication need, Chinese medicinal tablet roll, version 1040P of 2015). It is also documented that amino acid components, trace calcium and other trace elements in pearl powder are effective components for exerting medicinal effects. Under the condition of over-high temperature, amino acid can be denatured, so that pearl powder should be added under the condition of cooling the medicine in the preparation process.

The pearl powder has the effects of improving eyesight, removing nebula, clearing heat and relieving spasm. According to the modern pharmacological research of traditional Chinese medicines, the nacreous layer powder hydrolysate contains various amino acids and various trace elements, including 8 amino acids necessary for human body, has the capability of protecting water-soluble protein (SOD) and reduced Glutathione (GSH) in rat crystalline lens, can inhibit lipid peroxidation and remove active oxygen free radicals, and has the effect of preventing cataract.

Borneol, this product is borneol synthesized by processing turpentine, camphor and other raw materials. Borneol is pungent, bitter and slightly cold in property. It enters heart, spleen and lung meridians. Has effects in inducing resuscitation, refreshing mind, clearing away heat, and relieving pain. Can be used for treating fever unconsciousness, convulsion, apoplexy with phlegm syncope, qi stagnation and sudden syncope, central nausea and coma, thoracic obstruction, cardialgia, conjunctival congestion, aphtha, sore throat, and purulence in ear canal. Borneol has pungent and fragrant smell and has the efficacy of inducing resuscitation and refreshing mind, and the borneol has the similar function as musk and has slower efficacy. It is cool and cold in nature, and is suitable for treating block fever and coma; borneol is pungent and fragrant, and its fragrant smell can be used as a long herb to relieve pain. Borneol is bitter and cold in property, and has the functions of clearing heat and relieving pain, improving eyesight and removing nebula, promoting granulation and healing sore when being externally used (pharmacopoeia of the people's republic of China, clinical medication need know, volume of Chinese medicinal tablets, 1067P 2015 edition).

Menthol is composed of saturated cyclic alcohol obtained from oleum Menthae Dementholatum, and has effects of dispelling pathogenic wind, clearing away heat and toxic materials. The traditional Chinese medicine composition is mainly used for treating headache, conjunctival congestion and wind-heat common cold in clinic. When topically applied, it has effects of promoting blood circulation, relieving inflammation and itching, and can be used for relieving inflammation, itching, pain, and edema.

The invention has the advantages that:

the invention provides a pharmaceutical composition for preventing and treating myopia and asthenopia, which is prepared from the following components according to the concept of the invention into oral medicament and external medicament respectively, and the components of the formula have the effects of promoting blood circulation by removing blood stasis, improving blood circulation, maintaining eye nutrition, nourishing yin and kidney, clearing liver and improving vision, resisting fatigue and resisting oxidation. The medicine has the effects of dredging qi and blood, nourishing liver and kidney, nourishing blood, soothing nerves, promoting blood flow, improving blood circulation, regulating and controlling channels and collaterals, and improving eye muscle function, thereby realizing the treatment effect on myopia and asthenopia.

The pharmaceutical composition is added with pharmaceutically acceptable auxiliary materials to prepare an oral preparation, which undoubtedly brings more medication convenience for patients with myopia and asthenopia and is convenient to carry and take.

The pharmaceutical composition is added with proper auxiliary materials to prepare an external preparation, has more choices for the application of preventing and treating myopia and asthenopia, and achieves the ideal effect of treating the myopia and the asthenopia by utilizing the blood flow distribution of the capillary vessels in the eyes and the absorption and distribution of the capillary vessels around the eyes through the skin around the eyes.

Clinical tests prove that the oral preparation and the external preparation have obvious rehabilitation effect, short period, high cure rate and definite curative effect when being used for treating myopia or asthenopia; the use and return visit of patients prove that the product is safe to use, has no toxic or side effect, has no adverse reaction and has no treatment risk. The oral or external preparation has wide applicable population, and the product is satisfied after being treated and feels refreshing after being used for 8 years of age and 66 years of age at the minimum; the product of the invention is easy to be taken orally or externally, is easy to be popularized and popularized, and can benefit more myopes, especially asthenopia patients.

Detailed Description

Example 1

Preparation of the pharmaceutical composition:

prescription: 10 parts of safflower, 10 parts of salvia miltiorrhiza, 8 parts of ligusticum wallichii, 15 parts of white chrysanthemum, 10 parts of honeysuckle, 10 parts of coptis chinensis, 12 parts of green tangerine peel, 12 parts of mulberry leaves, 20 parts of phellinus igniarius, 20 parts of lucid ganoderma, 10 parts of wolfberry, 20 parts of semen cuscutae, 8 parts of ginseng, 20 parts of astragalus membranaceus, 10 parts of semen plantaginis, 12 parts of semen cassiae, 10 parts of concha haliotidis, 10 parts of spina date seeds, 12 parts of caltrops, 9 parts of oysters, 12 parts of cicada slough, 8 parts of spirulina, 10 parts of sea-buckthorn, 8 parts of ginger, 20 parts of human placenta, 6 parts of mint, 9 parts of liquorice;

the preparation method comprises the following steps:

(5) mixing the concentrated solutions I, II, III, IV and V obtained in the steps (2), (3) and (4), adding soluble pearl powder in parts by weight, fully and uniformly mixing to obtain a mixed concentrated solution, performing vacuum drying on the mixed concentrated solution at a low temperature of 45-50 ℃ until the water content is less than 5%, cooling, and crushing to obtain the pharmaceutical composition.

(II) preparation of capsules:

mixing the medicinal composition with beta-cyclodextrin according to the weight ratio of 1:0.5, fully and uniformly grinding, sieving with a 150-mesh sieve, sterilizing, and filling 1.5g of the medicinal composition into a No. 00 capsule to obtain the capsule.

When the capsule for preventing and treating the myopia and the asthenopia of the eyes is used for preventing and treating the asthenopia of the eyes or slight myopia, the dosage is 2 times a day, 1 capsule is taken each time, the capsule is taken 1 time after breakfast and supper, and 30 days are a course of treatment.

The preparation is administered 3 times a day, 2 granules each time, 1 time after breakfast, lunch and supper, and 30 days is a treatment course.

For treating eye asthenopia, 2 times daily, 2 granules each time, 1 time after breakfast and supper, and 7 days as a treatment course.

The capsule of the invention is tried out and treated 126 cases of mild myopia, the response rate is 98%, the cure rate is 86%; for 196 cases of moderate myopia, the effective rate is 92 percent, and the cure rate is 76 percent; the medicine can treat and relieve 320 cases of symptoms such as asthenopia, eye pain, dryness, blurred vision, eye foreign body sensation, eyelid heaviness, photophobia and lacrimation, and has an effective rate of 100% and a cure rate of 96%.

Typical cases are:

case 1: the programmer of a certain civil enterprise in Xuzhou city, 29 years old, faced with a computer every day for more than 9 hours, and worn 250-degree glasses with two eyes with slight myopia. Symptoms of dry eyes, dry eyes and painful eyes often appear, and the feeling is very tired.

The capsule prepared by the invention in the embodiment 1 is taken 3 times a day, 2 capsules each time, after breakfast, lunch and supper every day, the feeling effect is obvious after 10 days of medication, the symptoms such as eye pain, dry eyes, eye dryness and the like disappear, the mental state is relaxed, the capsule is continuously taken for 20 days, after one treatment course is finished, the dosage is adjusted downwards by 50 degrees by glasses, and the capsule is basically not required to be worn by glasses.

Case 2: xiaoya men and women, 12 years old, students in primary school of experiment in Xuzhou copper mountain area, with moderate myopia in both eyes, wear 400 degree glasses.

The capsule prepared by the invention in the embodiment 1 is taken 3 times a day, 1 capsule each time, and after breakfast and supper each day, the feeling is better after 10 days of administration, after 1 course of administration, the degree of the capsule is adjusted downwards by 50 degrees by glasses, the capsule is continuously used for 3 courses, and the glasses are not needed basically when people go to class.

Case 3: zhang Feng, male, 24 years old, a certain brand of mobile phone store in urban area, both eyes have 0.5, the previous treatment has been performed by laser surgery, but the vision rebounds after one year and returns to 0.5. after taking the capsule product prepared by the embodiment 1 of the invention, the capsule product is taken three times a day, 2 capsules are taken each time, the vision is recovered to 0.9 after 2 courses of treatment, the vision is recovered to 1.2 after the capsule product is continuously taken for 2 courses of treatment, and the capsule product is stopped for 1 year at present and has no rebound sign.

Case 4: wenxingchun, female, 42 years old, Xuzhou automobile trunk, vision of both eyes of 0.4, myopia lasts for 20 years, and there is no obvious effect when various medicines for treating myopia are used, the capsule product prepared by the invention in the embodiment 1 is taken three times a day, 2 capsules each time, in the morning, in the middle and at night, after 3 courses of treatment, the vision of both eyes reaches 0.8, and after 5 courses of treatment, the vision of both eyes reaches 1.0, and after one year of medicine withdrawal, the follow-up is carried out, and there is no rebound sign.

Case 5: the capsules prepared by the capsule product prepared by the invention in example 1 are taken three times a day, 2 capsules each time, according to the daily administration after breakfast, lunch and supper, and are relieved after treatment of one treatment course, and the binocular vision is 1.2 after three treatment courses. The return visit after 12 months has no rebound phenomenon.

Case 6: the capsule product prepared in the invention 1 is administrated to college students with naked eye vision of less than 0.3 for the left eye and less than 0.3 for the right eye of 19 years old for three times a day, 2 capsules are taken every time after breakfast, lunch and supper every day, the binocular vision is 0.6 after two treatment courses, the capsule product is continuously taken for three treatment courses, and the binocular vision is 1.1 after the treatment. After one year, the return visit is carried out without relapse.

Case 7: the capsule product prepared in the embodiment 1 of the invention is taken three times a day, 2 capsules each time, after breakfast, lunch and supper every day, after three treatment courses, the left-eye vision is 0.6, the right-eye vision is 0.8, the clinical symptoms are obviously improved, and the capsule is still in continuous treatment at present.

Case 8: yangxianzhen, female, a policeman in 29 years old, Xuzhou city, with a binocular vision of 1.4, due to the long-term use of computers, the eyes often feel dry, distending pain, blurred vision and other obvious asthenopia symptoms. The capsule product prepared in the embodiment 1 of the invention is taken 3 times a day, 2 capsules each time, 1 time after breakfast and supper each day, after 7 days of treatment in one treatment course, the symptoms are obviously relieved, after two treatment courses of continuous administration, the symptoms disappear, the patients feel refreshed, the eyes have no fatigue, and the patients return to visit after 6 months without rebound signs.

Case 9: heng ya Wei, male, 62 years old, and when a certain organ retires the cadres, the mobile phone always feels eye swelling, dry eyes, itching, eye socket pain and blurred vision for more than 6 hours each day. The capsule product prepared in the embodiment 1 of the invention is taken 2 times a day, 2 capsules each time, 1 time after breakfast and supper, the symptoms are obviously improved after 7 days of application for one treatment course, and the eye fatigue symptoms basically disappear after two treatment courses of continuous administration. The patient takes the medicine 1 granule every other week for 7 days, and takes the medicine once every morning and evening meal, the use time is up to 8 months, and symptoms such as eye swelling, dryness and eye pain do not appear during the administration period. The capsule product has better effect of preventing eyestrain.

In the revisiting of 126 cases of mild myopia treatment and 196 cases of moderate myopia and 320 cases of treating and relieving asthenopia, the capsule prepared by the invention has no toxic or side reaction such as allergy, gastrointestinal discomfort and the like, and patients all have normal reaction of diet, work and rest, normal regular urination and defecation and have no uncomfortable feeling. The survey and return visit information shows that the product of the invention has no big toxic and side effect and general adverse reaction. Can show that the product is safe and effective.

Example 2

Preparing a pharmaceutical composition:

prescription: 8 parts of safflower, 8 parts of salvia miltiorrhiza, 6 parts of ligusticum wallichii, 12 parts of white chrysanthemum, 8 parts of honeysuckle, 8 parts of coptis chinensis, 8 parts of green tangerine peel, 10 parts of mulberry leaves, 15 parts of phellinus igniarius, 15 parts of lucid ganoderma, 8 parts of wolfberry, 15 parts of semen cuscutae, 5 parts of ginseng, 15 parts of astragalus membranaceus, 5 parts of semen plantaginis, 5 parts of semen cassiae, 5 parts of concha haliotidis, 5 parts of spina date seeds, 8 parts of caltrops, 6 parts of oysters, 8 parts of cicada slough, 5 parts of spirulina, 5 parts of sea buckthorn, 6 parts of ginger, 12 parts of human placenta, 4 parts of mint, 6 parts of;

the preparation method comprises the following steps: the same as in example 1.

(II) preparation of tablets

Taking the pharmaceutical composition, adding starch, lactose and methyl cellulose, uniformly mixing, wetting by using 65% ethanol, preparing a soft material, granulating, drying, grading, mixing with magnesium stearate, and tabletting to obtain the tablet of the invention.

Example 3

Preparing a pharmaceutical composition:

prescription: 12 parts of safflower, 12 parts of salvia miltiorrhiza, 10 parts of ligusticum wallichii, 18 parts of white chrysanthemum, 12 parts of honeysuckle, 12 parts of coptis chinensis, 15 parts of green tangerine peel, 15 parts of mulberry leaves, 25 parts of phellinus igniarius, 25 parts of lucid ganoderma, 12 parts of wolfberry, 25 parts of semen cuscutae, 12 parts of ginseng, 30 parts of astragalus membranaceus, 15 parts of semen plantaginis, 15 parts of semen cassiae, 15 parts of concha haliotidis, 15 parts of spina date seeds, 16 parts of caltrops, 12 parts of oysters, 16 parts of cicada slough, 10 parts of spirulina, 15 parts of sea buckthorn, 12 parts of ginger, 25 parts of human placenta, 10 parts of mint, 12 parts of liquorice;

the preparation method comprises the following steps: the same as in example 1.

(II) preparation of granules:

taking the pharmaceutical composition, adding sucrose and dextrin, uniformly mixing, wetting by using ethanol with the concentration of 75% V/V, preparing a soft material, granulating, drying, grading, quantitatively packaging, and preparing the granule of the invention.

The invention also aims to provide an external preparation of the pharmaceutical composition for preventing and treating myopia and/or asthenopia, which can be prepared into solutions, powders, suspensions, ointments, plasters, creams, sprays and pastes, and is more preferably a paste. The material of the application agent is selected from non-woven fabric, the non-woven fabric is cut into a rectangle with the length of 18 cm and the width of 8 cm, the non-woven fabric is immersed into the prepared liquid medicine, the liquid medicine is taken out and drained after a certain time, and the liquid medicine is filled into a polypropylene or aluminum foil bag and sealed to obtain the adhesive. When in use, the non-woven fabric after being soaked is pasted on the periphery of eyes, and the non-woven fabric is selected to be pasted respectively in the morning and at the evening or in the morning, in the middle and at the evening according to different degrees of symptoms of myopia and asthenopia of patients, and the application time is 30-60 minutes each time.

The external preparation of the pharmaceutical composition for preventing myopia and/or asthenopia comprises the following specific embodiments:

example 1

Mixing 700g of polyethylene glycol 400 and 150g of propylene glycol uniformly, adding 50g of sodium carboxymethylcellulose, standing, soaking for 3 hours, stirring to dissolve uniformly, adding 100g of the pharmaceutical composition into the solution, stirring to dissolve, adjusting the pH value to 6.5-7.0, filtering to obtain a pharmaceutical composition liquid medicine, immersing the cut non-woven fabric into the liquid medicine for 8 hours, taking out the non-woven fabric soaked with the pharmaceutical composition, hanging and draining the flowing liquid medicine, filling into aluminum foil bags, sealing one sheet in each bag, packaging according to 100 bags per box after product packaging, and performing treatment on the pharmaceutical composition liquid medicine⁶⁰Co radiation sterilization to obtain; the pharmaceutical composition described in this embodiment is prepared from the following raw materials in parts by weight:

10 parts of safflower, 10 parts of salvia miltiorrhiza, 6 parts of ligusticum wallichii, 15 parts of white chrysanthemum, 10 parts of honeysuckle, 10 parts of coptis chinensis, 12 parts of green tangerine peel, 12 parts of mulberry leaves, 20 parts of phellinus igniarius, 20 parts of lucid ganoderma, 10 parts of wolfberry, 20 parts of semen cuscutae, 8 parts of ginseng, 20 parts of astragalus membranaceus, 10 parts of semen plantaginis, 10 parts of semen cassiae, 10 parts of concha haliotidis, 10 parts of spina date seeds, 12 parts of caltrops, 9 parts of oysters, 12 parts of cicada slough, 8 parts of spirulina, 10 parts of sea-buckthorn, 8 parts of ginger, 20 parts of human placenta, 9 parts of liquorice, 6 parts of pearl powder, 6 parts of;

the preparation method comprises the following steps:

Clinical trials prove that the application agent prepared in the embodiment can be used for treating and relieving symptoms such as eye pain, dryness, eye swelling and the like for 420 cases, the effective rate is 100%, and the cure rate is 90%. For 120 cases of pseudomyopia treatment, the effective rate is 95%, and the cure rate is 75%.

Typical cases are:

case 1

The patients: likeka, male, 30 years old

Symptoms are: when the user touches a computer for a long time, the user often feels pain, fullness and dryness of eyes.

The eye pain and dryness symptoms are relieved after the eye patch is applied to the periphery of the eyes, the eye patch is applied for 30 minutes in the morning and at the evening, and the eye patch is applied to the eyes for 2 days. The symptoms disappear after the patient uses the medicine for one course.

Case 2

The patients: zhang Feng, male, 16 years old, school student

Symptoms are: pseudomyopia, moderate myopia in both eyes, and 450-degree myopia glasses.

The patch is applied to eyes for 10 days for a treatment course, the feeling is better, the patch has obvious curative effect after being applied to the eyes for 2 treatment courses, and the glasses are adjusted by 150 degrees after being applied to the eyes for two treatment courses. Continuously consolidate 2 courses of treatment, if the user does not need to wear glasses in class.

Case 3

The patients: sing Hai Wei, male, 12 years old, school student

Symptoms are: pseudomyopia, which is not worn all the time, often causes dry eyes and malaise eyes, and frequently blinks habitually.

The patch is applied to the periphery of eyes once a day in the morning and at night, each time is 30 minutes, the phenomenon of dry eyes is obviously reduced after the patch is used for 5 days, and after one course of treatment of eye application, eyes do not feel dry and get rid of the bad habit of frequent eye blinking. Then, the eye is applied once a day at night, and the consolidation treatment is carried out for 30 minutes each time. Half a year later, the symptoms disappear completely.

Case 4

Patient, Zhang Xiaoxia, girl, 16 years old, student at school

Symptoms are: pseudomyopia, moderate myopia in both eyes, and wearing 400-degree myopia glasses.

The patch is applied to eyes once in the morning and at night, each time is 30 minutes, after five days, the feeling is better, after two courses of eye application, the glasses are lowered by 50 degrees, the glasses are continuously used for 3 courses, and the glasses are basically not needed to be worn in class.

Case 5

Patient, Du Xiao Yang, male, 12 years old, student at school

Symptoms are: pseudomyopia, mild myopia in both eyes, left eye < 0.6, right eye < 0.8, no glasses, but dry eye, eye puckery, eye pain, and very tired feeling.

The patch is applied to the periphery of eyes once in the morning and at night every day, each time is 30 minutes, symptoms are relieved after continuous use for 5 days, the patch has relaxed feeling, the application symptoms disappear after three treatment courses of insistence, and the eyes are corrected for vision by two eyes by 1.2. The disease does not relapse after one-year return visit.

Case 6

The patients: the people of the folk nationality, women, age 32 and white collar, face the computer for more than 8 hours every day, and often feel dry and astringent eyes, eye pain, lacrimation and sour and swollen eyes.

The application agent is applied to the periphery of eyes once a day in the morning and at night, so that the dry eye symptom is obviously improved after one treatment course, the periphery of the eyes gradually generates heat, and the blood circulation is promoted. The three courses of treatment are insisted on, the previous symptoms are basically improved, and the eyestrain is obviously improved.

Case 7

The patients: shangbeiyun, male, age 68, electrician professional retirement.

Symptoms are: the old people can watch the mobile phone all day and the eyesight of the old people is rapidly reduced, the eyes are sore and painful, the old people often tear and cannot see things clearly in recent years.

After the patch is applied to the periphery of eyes for 10 days, the situation of tearing of the eyes is obviously improved, the eyes are not dry and astringent, and the symptoms of ache are obviously relieved. After the patient returns visit after being stopped for 6 months, the patient can self-tell that the symptoms of dry eyes and ache disappear, and the eyes do not lacrimate.

It should be noted that: the above description is only a preferred embodiment of the present invention, and is not intended to limit the present invention, and it is obvious to those skilled in the art that modifications and partial replacement of technical features of the present invention may be made in the foregoing embodiments. Any modification, modification or substitution made within the basic principle of the present invention should be considered as the protection scope of the present invention.

Claims

1. A pharmaceutical composition for preventing and treating myopia and/or asthenopia is characterized by being prepared from the following raw materials in parts by weight: 8-12 parts of safflower, 8-12 parts of salvia miltiorrhiza, 6-10 parts of ligusticum wallichii, 12-18 parts of white chrysanthemum, 8-12 parts of honeysuckle, 8-12 parts of coptis chinensis, 8-15 parts of green tangerine orange peel, 10-15 parts of mulberry leaves, 15-25 parts of phellinus igniarius, 15-25 parts of lucid ganoderma, 8-12 parts of wolfberry fruit, 15-25 parts of semen cuscutae, 5-12 parts of ginseng, 15-30 parts of astragalus membranaceus, 5-15 parts of semen plantaginis, 5-15 parts of semen cassiae, 5-15 parts of concha haliotidis, 5-15 parts of spina date seeds, 8-16 parts of caltrops, 6-12 parts of oysters, 8-16 parts of periostracum cicada, 5-10 parts of spirulina, 5-15 parts of sea buckthorn, 6-12 parts of ginger, 12-25 parts of placenta hominis, 4-10 parts of mint, 6-12 parts of.

2. The pharmaceutical composition for preventing and treating myopia and/or asthenopia according to claim 1, which is prepared from the following raw materials in parts by weight: 10 parts of safflower, 10 parts of salvia miltiorrhiza, 8 parts of ligusticum wallichii, 15 parts of white chrysanthemum, 10 parts of honeysuckle, 10 parts of coptis chinensis, 12 parts of green tangerine peel, 12 parts of mulberry leaves, 20 parts of phellinus igniarius, 20 parts of lucid ganoderma, 10 parts of wolfberry, 20 parts of semen cuscutae, 8 parts of ginseng, 20 parts of astragalus membranaceus, 10 parts of semen plantaginis, 12 parts of semen cassiae, 10 parts of concha haliotidis, 10 parts of spina date seeds, 12 parts of caltrops, 9 parts of oysters, 12 parts of cicada slough, 8 parts of spirulina, 10 parts of sea-buckthorn, 8 parts of ginger, 20 parts of human placenta, 6 parts of mint, 9 parts of liquorice.

3. The method for preparing a pharmaceutical composition for the prevention and treatment of myopia and/or ocular fatigue according to claim 1 or 2, characterized by comprising the steps of:

(2) mixing the medicinal powder obtained in step (1), moistening with edible ethanol for 40-50 hr, and adding edible ethanol at a dose of 0.3-1.5ml/kg^-1Collecting percolate until the percolate turns light yellow, recovering ethanol from the percolate, filtering, heating and concentrating to relative density of 1.75-2.25/50 deg.C to obtain concentrated solution I; adding purified water 8-10 times of the weight of the medicinal materials into the percolate, decocting with strong fire for 2 hours, then decocting with slow fire for 1 hour, filtering to obtain decoction, and concentrating the decoction to relative density of 1.72-2.25/50 deg.C to obtain concentrated solution II;

(3) cleaning Carthami flos, flos Chrysanthemi, flos Lonicerae, Ginseng radix, and herba Menthae, respectively, microwave drying, grinding into 40-50 mesh powder, mixing the powders, adding edible ethanol, soaking at room temperature for three times, wherein the amount of ethanol is 5-10 times of the weight of the medicinal materials, the soaking time is 5-7 days, mixing the three soaking solutions, recovering ethanol, filtering, and concentrating to relative density of 1.15-1.25/50 deg.C to obtain concentrated solution III; adding purified water 5 times the weight of the medicinal materials into the soaked medicine residues, heating and decocting for 2 hours, taking decoction, filtering, and concentrating until the relative density is 1.15-1.25/50 ℃ to obtain concentrated solution IV for later use;

(4) microwave drying placenta hominis, grinding into 50 mesh powder, adding 10 times, 8 times and 5 times of normal saline, boiling and extracting for three times, wherein the boiling time is 1 hour each time, mixing decoctions, filtering, adjusting pH of the filtrate to 3.1-3.2 with 0.1mol hydrochloric acid, standing in a refrigerator for 24-36 hours, precipitating completely, collecting supernatant, filtering, and heating and concentrating the filtrate to relative density of 1.05-1.12/50 deg.C to obtain concentrated solution V;

4. The pharmaceutical composition for preventing and treating myopia and/or asthenopia according to claim 1 or 2, wherein the pharmaceutical composition is an oral preparation.

5. The pharmaceutical composition for preventing and treating myopia and/or asthenopia according to claim 4, wherein the oral preparation is oral liquid, syrup, tablet, capsule, granule, pill or paste.

6. The pharmaceutical composition for preventing and treating myopia and/or asthenopia according to claim 5, wherein the oral preparation is tablet or capsule.

7. A pharmaceutical composition for preventing and treating myopia and/or asthenopia is characterized by being prepared from the following raw materials in parts by weight: 8-12 parts of safflower, 8-12 parts of salvia miltiorrhiza, 6-10 parts of ligusticum wallichii, 12-18 parts of white chrysanthemum, 8-12 parts of honeysuckle, 8-12 parts of coptis chinensis, 8-15 parts of green tangerine orange peel, 10-15 parts of mulberry leaves, 15-25 parts of phellinus igniarius, 15-25 parts of lucid ganoderma, 8-12 parts of wolfberry fruit, 15-25 parts of semen cuscutae, 5-12 parts of ginseng, 15-30 parts of astragalus membranaceus, 5-15 parts of semen plantaginis, 5-15 parts of semen cassiae, 5-15 parts of concha haliotidis, 5-15 parts of spina date seeds, 8-16 parts of caltrops, 6-12 parts of oysters, 8-16 parts of periostracum cicada, 5-10 parts of spirulina, 5-15 parts of sea buckthorn, 6-12 parts of ginger, 12-25 parts of placenta hominis, 6-12 parts of liquorice, 4-8 parts of, 4-8 parts of menthol.

8. The pharmaceutical composition for preventing and treating myopia and/or asthenopia according to claim 7, which is prepared from the following raw materials in parts by weight: 10 parts of safflower, 10 parts of salvia miltiorrhiza, 6 parts of ligusticum wallichii, 15 parts of white chrysanthemum, 10 parts of honeysuckle, 10 parts of coptis chinensis, 12 parts of green tangerine peel, 12 parts of mulberry leaves, 20 parts of phellinus igniarius, 20 parts of lucid ganoderma, 10 parts of wolfberry, 20 parts of semen cuscutae, 8 parts of ginseng, 20 parts of astragalus membranaceus, 10 parts of semen plantaginis, 10 parts of semen cassiae, 10 parts of concha haliotidis, 10 parts of spina date seeds, 12 parts of caltrops, 9 parts of oysters, 12 parts of cicada slough, 8 parts of spirulina, 10 parts of sea-buckthorn, 8 parts of ginger, 20 parts of human placenta, 9 parts of liquorice, 6 parts of pearl powder, 6 parts of.

9. The method for preparing a pharmaceutical composition for the prevention and treatment of myopia and/or asthenopia according to claim 7 or 8, which comprises the steps of:

(2) and (3) soaking the filter residue obtained in the step (1) for three times according to the weight of the medicinal materials of 1: adding purified water at a ratio of 15-20, decocting with strong fire for 3 hr, decocting with slow fire for 1 hr, filtering to obtain decoction, and concentrating to obtain concentrated solution with specific gravity of 1.15/50 deg.C;

10. The pharmaceutical composition for preventing and treating myopia and/or asthenopia according to claim 7 or 8, which is an external preparation.

11. The pharmaceutical composition for the prevention and treatment of myopia and/or asthenopia according to claim 10, wherein the external preparation is a solution, powder, suspension, ointment, plaster, cream, patch or spray.

12. The pharmaceutical composition for the prevention and treatment of myopia and/or asthenopia according to claim 11, wherein the external preparation is an ointment, a patch or a spray.

13. The pharmaceutical composition for the prevention and treatment of myopia and/or asthenopia according to claim 12, wherein the external preparation is a patch.