CN112450918B

CN112450918B - Implanting device of implantable biosensor

Info

Publication number: CN112450918B
Application number: CN202011361444.XA
Authority: CN
Inventors: 杨凯洪; 费英杰
Original assignee: Zhejiang Poctech Corp
Current assignee: Zhejiang Poctech Corp
Priority date: 2020-11-27
Filing date: 2020-11-27
Publication date: 2022-12-06
Anticipated expiration: 2040-11-27
Also published as: CN112450918A

Abstract

The invention relates to a novel implanting device of an implantable biosensor, which comprises an implantable biosensor implanter, wherein an implantable sensor fixing device for placing the implantable biosensor without bending is obliquely clamped at the transmitting end of the implantable biosensor implanter, the implantable sensor fixing device is placed on a base, and the base is detachably and fixedly connected with the implantable biosensor implanter. Push away the implantation biosensor fixing device to the fixed slot of base through implantation biosensor implanter to alright detect in implanting the skin with the detection portion that will not need to buckle the sensor, realized implantation sensor and need not to buckle the sensor after implanting the skin, prevent to receive the influence owing to buckle the sensitivity that leads to the sensor, make the more accurate of effect that detects.

Description

Implanting device of implantable biosensor

Technical Field

The invention relates to the field of implantable biosensors, in particular to an implanting device of an implantable biosensor.

Background

Monitoring of blood glucose is very important for diabetics, and blood glucose values help to assess conditions of glucose metabolism disorders in diabetics. Currently, the detection of blood glucose can be divided into in vitro detection after blood collection and real-time detection of an implantable blood glucose sensor. When blood sugar is controlled by the method of in vitro detection after blood collection, blood collection is required to be performed for many times every day, and heavy burden is imposed on the spirit and the flesh of a patient, so that the method of real-time detection by an implantable blood sugar sensor is increasingly popular.

At present, the biosensor can be used for clinical blood sugar continuous monitoring products, and only a micro sensor implanted in subcutaneous tissues is technically verified to a certain degree, so that a small and soft biosensor is required to be flexibly implanted into a detection part in the field to be implanted under the skin, a puncture tube penetrates into the skin at a very high speed to reduce pain to be extremely low, an electrode part of the sensor is left under the skin, continuous monitoring is realized, and the part on the skin of the sensor is required to be fixed with the skin. For example, patent document No. CN201610985667.0 discloses a biosensor electrode elastic force type implantation device and a use method thereof, a puncture combined sleeve, an elastic force type mechanism and a specific stress structure are adopted to realize automatic puncture, and after a puncture needle exits from a silica gel seat, the silica gel seat rotates along with a rotating seat to be attached to the bottom surface of a sensor base in parallel, so that a sensor is embedded in the silica gel seat; also, as disclosed in patent document No. CN201310724053.3, a sensor device in subcutaneous tissue capable of controlling an implantation angle is disclosed, in which an electrode is implanted into a human body by matching an implantation device and a sensor assembly, and a sensor mounting seat is pushed into a guide seat, and after a half-wall needle is withdrawn, the guide seat is rotated to be clamped with the implantation seat, so that the sensor mounting seat is embedded therein, the above fixing method has a problem in that the skin upper portion of the sensor needs to be manually pressed flat, which causes the electrode portion of the sensor to bend, and the electrode portion is laminated and bonded by a plurality of electrodes and insulating layers.

Disclosure of Invention

The implantation device comprises an implantable biosensor implanter, wherein an implantable sensor fixing device for placing an implantable biosensor without bending is obliquely clamped at the emitting end of the implantable biosensor implanter, the implantable sensor fixing device is placed on a base, the base is detachably and fixedly connected with the implantable biosensor implanter, when the implantable biosensor implanting device is used, the implantable biosensor without bending is only required to be placed into the implantable sensor fixing device, the implantable sensor fixing device is installed at the emitting end of the implantable biosensor implanter, the base is detachably connected with the implantable biosensor implanter, then the base is attached to the surface of the skin, the implantable sensor fixing device is pushed into a fixing clamping groove of the base through the implantable biosensor implanter, so that the detection of the sensor without bending is realized, the sensor is not required to be bent after the implantable sensor is implanted into the skin, the influence on the sensitivity of the sensor due to bending is prevented, meanwhile, the emitting end of the implantable biosensor implanter and the fixing device are obliquely arranged, the implanted sensor can be implanted into the skin, the detection effect of the implantable biosensor can be more accurately ensured, and the blood can be detected in a deeper state.

The utility model provides an implantation device of implantation biosensor, is including implantation biosensor implantation ware, the transmission end slope joint of implantation biosensor implantation ware has the implantation sensor fixing device who places the implantation biosensor that need not buckle, implantation sensor fixing device places and on the base, the base with implantation biosensor implantation ware can dismantle fixed connection.

Preferably, the base rotates to be connected with the lid of mutually supporting, the shaping has and implants ware complex installation department with implantation nature biosensor on the base, seted up on the lid with installation department complex installation cavity, the edge of installation department sets up the fixed slot who is used for spacing implantation nature sensor fixing device, fixed slot has seted up the breach on being close to one side cell wall of implantation nature biosensor electrical contact, be fixed with the sealing washer on the lateral wall of laminating mutually with implantation nature biosensor electrical contact place side on the installation cavity.

Preferably, the implantable sensor fixing device comprises a lower fixing seat and an upper fixing seat which are mutually matched, a fixing groove for placing the implantable biosensor which does not need to be bent is formed in the lower fixing seat, a first clamping groove is formed in the groove wall of the fixing groove along the length direction of the fixing groove, a first buckle mutually matched with the lower fixing seat is formed in the side wall of the upper fixing seat, and electrode holes are formed from the upper surface to the lower surface of the upper fixing seat.

Preferably, the implantable biosensor comprises a blank electrode layer, a working electrode layer, a reference electrode layer and a counter electrode layer, wherein the blank electrode layer, the working electrode layer, the reference electrode layer and the counter electrode layer respectively comprise a circuit contact part and a flexible implantation detection part, a transition connection part between the circuit contact part and the flexible implantation detection part is in a bending design, and a bending angle C between the circuit contact part and the flexible implantation detection part is 120-150 degrees.

Preferably, the side of fixing base along width direction one side down is the second inclined plane of mutually supporting with the flexible implantation detection portion of implantation nature biosensor, the shaping of second inclined plane one side of fixing base has first fixture block down, down the fixing base with the relative side shaping of second inclined plane has the second fixture block, first fixture block is kept away from with the second fixture block down the one side of fixing base all with the second inclined plane is parallel to each other, the one side shaping that the fixing base shaping has the second fixture block down has the third stopper, the third stopper is kept away from down the side of fixing base with the second inclined plane is parallel to each other.

Preferably, the fixed clamping groove is matched with the overall dimension of the implantable biosensor fixing device, a groove is formed in the groove wall adjacent to the notch of the fixed clamping groove, a clamping block used for limiting the implantable sensor fixing device is formed in the groove wall of the groove, one end of the clamping block is fixed with the groove wall of the groove, and the other end of the clamping block is a free end and extends into the fixed clamping groove in an inclined mode.

Preferably, a through hole for passing through the half-wall needle is formed in one end, far away from the clamping block, of the bottom of the fixing clamping groove, an upper arc-shaped groove and a lower arc-shaped groove are formed in the lower fixing seat and the upper fixing seat respectively, and the upper arc-shaped groove and the lower arc-shaped groove form a through hole for passing through the half-wall needle.

Preferably, a limiting rotation shaft hole is formed in the base, a first limiting block is formed in the limiting rotation shaft hole, a limiting rotation shaft matched with the limiting rotation shaft is formed on the cover body, a second limiting block matched with the first limiting block is formed at one end, away from the cover body, of the limiting rotation shaft, and the distance between the end face, away from the cover body, of the first limiting block and the top face of the limiting rotation shaft hole is equal to the distance between the end face, close to the cover body, of the second limiting block and the cover body.

Preferably, keep away from on the installation department fixed slot's side shaping has the locking elastic block, the locking elastic block is kept away from the one end of installation department extends to be close to the edge of base, have complex buckle seat with it at its relevant position shaping on the lateral wall of installation cavity.

Preferably, a bump is formed at the edge of the base far away from the limiting rotation shaft hole, a second clamping groove is formed in the side face of the bump, and a clamping block matched with the cover body is formed at the corresponding position of the cover body.

The invention has the beneficial effects that:

(1) The implantation device comprises an implantable biosensor implanter, wherein an implantable sensor fixing device for placing an implantable biosensor without bending is obliquely clamped at the emitting end of the implantable biosensor implanter, the implantable sensor fixing device is placed on a base, the base is detachably and fixedly connected with the implantable biosensor implanter, when the implantable biosensor implanting device is used, the implantable biosensor without bending is only required to be placed into the implantable sensor fixing device, the implantable sensor fixing device is installed at the emitting end of the implantable biosensor implanter, the base is detachably connected with the implantable biosensor implanter, then the base is attached to the surface of the skin, the implantable sensor fixing device is pushed into a fixing clamping groove of the base through the implantable biosensor implanter, so that the detection of the sensor without bending is realized, the sensor is not required to be bent after the implantable sensor is implanted into the skin, the influence on the sensitivity of the sensor due to bending is prevented, meanwhile, the emitting end of the implantable biosensor implanter and the fixing device are obliquely arranged, the implanted sensor can be implanted into the skin, the detection effect of the implantable biosensor can be more accurately ensured, and the blood can be detected in a deeper state.

(2) The base is provided with an installation part matched with the implantable biosensor implanter, the cover body is provided with an installation cavity matched with the installation part, the edge of the installation part is provided with a fixed clamping groove used for limiting the implantable biosensor transmission fixing device, one side wall of the fixed clamping groove, which is close to the sensor electric contact, is provided with a notch, a side wall, which is attached to the side face where the sensor electric contact is located, of the installation cavity is fixedly provided with a sealing ring, after the implantable biosensor fixing device carries the implantable biosensor which does not need bending to enter the fixed clamping groove, the electric contact of the electrode column on the implantable biosensor faces to one side of the notch and is exposed, the limiting rotating shaft arranged on the cover body is inserted into the limiting rotating shaft hole arranged on the base through a certain angle, then the cover body is rotated to enable the clamping seat on the cover body to be clamped with the locking elastic block on the installation part, and the sealing ring rotates along with the cover body to be tightly attached to the side face of the sensor fixing device, so that the electric contact of the electrode column is sealed, external liquid medium is isolated from contacting the electric contact of the electrode column, the sealing effect is achieved, and the monitoring accuracy of bathing and swimming is not influenced.

(3) The fixing device comprises a lower fixing seat and an upper fixing seat which are matched with each other, wherein a fixing groove for placing the implantable sensor which does not need to be bent is formed in the lower fixing seat, a through groove is formed in the side wall of the lower fixing seat along the length direction of the fixing groove, a first buckle matched with the lower fixing seat is formed in the side wall of the upper fixing seat, an electrode hole is formed in the upper surface to the lower surface of the upper fixing seat, when the fixing device is used, the implantable biosensor is placed into the fixing groove, the electrode column is in interference fit into the electrode hole through the electrode hole, the upper fixing seat is embedded into the lower fixing seat through the matching of the buckle and the clamping groove, a contact of the electrode column is exposed, and meanwhile, only the exposed electrode column contact is protruded on the upper surface of the upper fixing seat through the arrangement of the buckle and the clamping groove on the side edge, so that after the electrode column is implanted into a skin fixing seat in a later period, a sealing ring on a cover body of the skin fixing seat can completely cover the contact of the electrode column, and the upper surface of the upper fixing seat is prevented from being contacted with the electrode column due to the fact that water permeates through the difference in height of the surface.

(4) The implantable biosensor is of a layered structure and comprises a blank electrode layer, a working electrode layer, a reference electrode layer and a counter electrode layer, wherein the blank electrode layer, the working electrode layer, the reference electrode layer and the counter electrode layer respectively comprise a circuit contact part and a flexible implantation detection part, and a transition connection part between the circuit contact part and the flexible implantation detection part is in a bending design.

Description of the drawings:

FIG. 1 is a schematic diagram of an implanter apparatus in split view;

FIG. 2 is an overall schematic of the present invention;

fig. 3 is an inside elevational view of the implanter of the present invention with half the housing removed;

FIG. 4 is a rear interior view of the implanter of the present invention with half of the housing removed;

FIG. 5 is a half-sectional view of an implanter housing of the present invention;

FIG. 6 is a three-dimensional view of the slide chair of the present invention;

FIG. 7 is a front view of the slide block of the present invention;

FIG. 8 is a rear elevational view of the slide base of the present invention;

FIG. 9 is a rear half sectional view of the slide clamp sensor assembly of the present invention;

FIG. 10 is an enlarged, fragmentary view of FIG. 9A of the present invention;

FIG. 11 is a front view of a sensor assembly of the present invention;

FIG. 12 is a rear elevational view of the sensor assembly of the present invention;

FIG. 13 is a view of the split seat of the present invention in combination with a half-wall needle;

FIG. 14 is a back schematic view of an implantable biosensor of the present invention;

FIG. 15 is a schematic structural view of the present invention;

FIG. 16 is an exploded view of FIG. 15;

FIG. 17 is a schematic structural view of a base according to the present invention;

FIG. 18 is a schematic structural view of a base according to the present invention;

FIG. 19 is a top view of the base of the present invention;

FIG. 20 is a cross-sectional view taken along line FF of FIG. 19;

FIG. 21 is a schematic structural view of the upper cover;

FIG. 22 is a schematic view of an implantable sensor fixation device of the present invention in split configuration;

FIG. 23 is a schematic view of a lower mounting bracket of the present invention;

FIG. 24 is a side view of the upper mounting base of the present invention;

FIG. 25 is a schematic view of an implantable biosensor according to the present invention

FIG. 26 is a schematic exploded view of an implantable biosensor according to the present invention;

FIG. 27 is a schematic view of an implantable sensor fixation device of the present invention passing through a hole;

in the drawings: 1. implanting into the mouth; 2. implanting the device into a housing; 3. a sliding seat; 5. a semi-through slot; 6. a guide groove; 7. a separation plate; 8. a sensor fixture block; 9. a separating seat clamping block; 10. clamping a plate; 11. an installation port; 12. an implanter cover; 13. an elastic clip; 14. reinforcing ribs; 15. a sliding groove; 16. clamping the strip; 17. a clamping hole; 18. a hook-shaped chuck; 19. a button fixture block; 20. a propulsion spring; 21. an annular groove; 22. separating the seat hook; 23. a barb; 24. a separation spring; 25. a sensor assembly; 26. a separating seat; 27. a semi-wall needle; 30. A sensor fixture recess; 31. a separation seat groove; 32. a separation tank; 34. a button; 36. 100, a base; 110. an installation part; 120. fixing the clamping groove; 121. a notch; 122. a groove; 123. a clamping block; 124. a through hole; 125. an empty groove; 130. limiting a rotating shaft hole; 131. a first stopper; 132. a guide block; 140. locking the elastic block; 141. briquetting; 150. a bump; 151. a second card slot; 160. positioning a block; 170. a clamping groove; 200. a cover body; 210. a mounting cavity; 211. a seal ring; 212. a buckle seat; 220. limiting the rotating shaft; 221. a second limiting block; 230. a clamping block; 40, a lower fixed seat; 401. fixing grooves; 402. a first card slot; 403. a second inclined surface; 404. a first clamping block; 405. a second fixture block; 406. a third limiting block; 407, a lower arc groove; 41. an upper fixed seat; 411. a first buckle; 412. an electrode hole; 413, an upper arc-shaped groove; 414. an electrode column; 50. an implantable biosensor; 501. a blank electrode layer, 502 a working electrode layer, 503 a reference electrode layer, 504 a counter electrode layer, 505 a circuit contact part, 506 a flexible implantation detection part; 43. an implantable sensor fixation device; 70. an implantable biosensor implanter;

the specific implementation mode is as follows:

the technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

In the description of the present invention, it is to be understood that the terms "central," "longitudinal," "lateral," "length," "width," "thickness," "upper," "lower," "front," "rear," "left," "right," "vertical," "horizontal," "top," "bottom," "inner," "outer," "clockwise," "counterclockwise," "axial," "radial," "circumferential," and the like are used in the orientations and positional relationships indicated in the drawings for convenience in describing the invention and to simplify the description, and are not intended to indicate or imply that the referenced devices or elements must have a particular orientation, be constructed and operated in a particular orientation, and are therefore not to be considered limiting of the invention.

In the present invention, unless otherwise expressly specified or limited, the terms "disposed," "mounted," "connected," and "fixed" are to be construed broadly and may, for example, be fixedly connected or detachably connected; may be a mechanical connection; may be directly connected or indirectly connected through an intermediate. The specific meanings of the above terms in the present invention can be understood by those skilled in the art according to specific situations.

Furthermore, the terms "first", "second", etc. are used for descriptive purposes only and are not to be construed as indicating or implying relative importance or implicitly indicating the number of technical features indicated. Thus, a feature defined as "first" or "second" may explicitly or implicitly include one or more of that feature.

According to the present invention, as shown in fig. 1-27, there is provided a technical solution:

the utility model provides an implantation device of implantation biosensor, is including implantation biosensor implanter 70, implantation biosensor implanter 70's transmission end slope joint has the implantation sensor fixing device 43 of placing implantation biosensor 50 that need not buckle, implantation biosensor implanter 70's transmission end is ascending first inclined plane, and implantation sensor fixing device 43 is the horizontal plane with the face of implantation biosensor implanter 70 joint, and the face of separating seat 26 and implantation sensor fixing device 43 contact simultaneously and implantation biosensor implanter 70's transmission end are the inclined plane of tilt up and are parallel to each other with it, can guarantee like this that implantation biosensor implanter 70 with can incline when implantation sensor fixing device 43 connects, implantation sensor fixing device 43 places on with base 100, base 100 with implantation biosensor implanter 70 can dismantle fixed connection.

Specifically, base rotation is connected with lid 200 that mutually supports, and base 100 and lid 200 can be made by plastics, and the lower surface of base 100 is equipped with and is used for the adhesive tape fixed with skin, is equipped with the battery that provides the power for the sensor in the lid 200 and is used for transmitting the wireless data transmission portion of monitoring data, the shaping has on the base 100 with implantation nature biosensor implanter 70 complex installation department 110, seted up on the lid 200 with installation department 110 complex installation cavity 210, the edge of installation department 110 is seted up and is used for spacing implantation nature sensor fixing device 43's fixed slot 120, fixed slot 120 has seted up breach 121 on being close to one side cell wall of implantation nature biosensor 50 electrical contact, be fixed with sealing washer 211 on the lateral wall of laminating mutually with implantation nature biosensor 50 electrical contact place on the installation cavity 210, be equipped with the electrical contact who contacts with in the sealing washer 211, after installation sensor fixing device, sealing washer 121 closely laminates with the side at electrical contact place to reach waterproof effect.

Specifically, the implantable sensor fixing device 43 includes a lower fixing seat 40 and an upper fixing seat 41 which are mutually matched, the upper fixing seat 41 is made of silica gel, a fixing groove 401 for placing the implantable biosensor 50 which does not need to be bent is formed in the lower fixing seat 40, a first clamping groove 402 is formed on a groove wall of the fixing groove 401 along the length direction, a first buckle 411 which is mutually matched with the lower fixing seat 40 is formed on a side wall of the upper fixing seat 41, an electrode hole 412 is formed from the upper surface to the lower surface of the upper fixing seat 41, an electrode column 414 is embedded into the electrode hole 212, the upper fixing seat 41 is embedded into the lower fixing seat 40 through the matching of the buckle and the clamping groove 402, so that a contact of the electrode column is exposed, and the lower fixing seat 40 and the upper fixing seat 41 are tightly attached to each other, make the circuit contact part 505 that need not the implantation biosensor 50 of buckling possess waterproof function, simultaneously through setting up buckle and first draw-in groove 402 at the side, make the upper surface of going up fixing base 41 only expose outside electrode column contact outstanding, be convenient for after the later stage is implanted base 100, the contact of electrode column 414 can be covered completely to sealing washer 211 on the lid 200 of base 100, prevent that water from contacting electrode column 414, make fixing device wholly possess waterproof function, prevent to go up the upper surface of fixing base because the surface height is different, lead to water infiltration and contact the electrode column, make fixing device and skin fixing base 60 cooperate the use back, the circuit contact part that can make implantation biosensor possesses waterproof effect, make implantation biosensor also can the operation in the environment that has liquid.

Specifically, the cross section of the first buckle 411 is trapezoidal, the inclined angle a of the inclined surface of the first buckle 411 close to the bottom surface of the fixing groove 401 is 20-30 °, and when the upper fixing base is implanted into the lower fixing base 40, the first buckle 411 can be conveniently clamped into the first clamping groove 402 of the lower fixing group 40 due to the large inclined angle, so that the assembly is facilitated.

Specifically, the implantable biosensor 50 is a layered structure, and includes a blank electrode layer 501, a working electrode layer 502, a reference electrode layer 503 and a counter electrode layer 504, the blank electrode layer 501, the working electrode layer 502, the reference electrode layer 503 and the counter electrode layer 504 each include a circuit contact portion 505 and a flexible implantation detection portion 506, and a transition connection portion between the circuit contact portion 505 and the flexible implantation detection portion 506 is in a bending design.

Specifically, the bending angle C between the circuit contact part 505 and the flexible implantation detection part 506 is 120-150 degrees, the bending design between the implanted biological circuit contact part 505 and the flexible implantation detection part 506 is ensured, and meanwhile, when the circuit contact part 505 is parallel to the skin, the flexible implantation detection part 506 is obliquely implanted into the skin, the oblique implantation can ensure that the blood implanted into the skin by the reinforced flexible implantation detection part 506 is deeper under the same implantation depth, so that the detection effect is more accurate.

Specifically, the transitional connection part between the circuit contact 505 and the flexible implantation detection part 506 is in a circular arc shape, so that the connection strength is ensured;

specifically, the thickness of the blank electrode layer 501, the working electrode layer 502, the reference electrode layer 503 and the counter electrode layer 504 after lamination is 0.25 to 0.3mm, so that the blank electrode layer can be thinned to the maximum extent, the light volume is ensured, and the use is convenient.

Specifically, the width C of the end of the flexible implantation detection part 506 away from the circuit contact part 505 is 0.07-0.14mm, so that the wound area of the skin is reduced, the foreign body sensation is reduced, and the use comfort level is increased.

Specifically, the structural strength of the flexible implantation detection portion 506 gradually decreases from the root connected to the circuit contact portion 505 to the end away from the circuit contact portion 505, and the gradual decrease of the structural strength may be linear or stepped, such that the thickness of the flexible implantation detection portion changes and becomes thinner when the flexible implantation detection portion is away from the root, and the stimulation to the tissue is further reduced, and similarly, the flexibility increases when the thickness of the flexible implantation detection portion is close to the root, and the flexible implantation detection portion can be prevented from breaking; because the stress of the sensor is larger and larger along with the gradual approach to the root, if the thickness of the sensor is made to be consistent, the sensor is easy to break or crack in order to avoid stimulating the subcutaneous tissue to be thinner, especially, the sensor is more stressed and more concentrated in stress and is also easier to break and crack in the place close to the root, and the measurement precision of the sensor can be influenced.

Specifically, the circuit contact portions 505 of the blank electrode layer 501, the working electrode layer 502, the reference electrode layer 503 and the counter electrode layer 504 are all rectangular parallelepipeds and have the same width, so that the overall aesthetic property is ensured, and the processing technology is simple.

Specifically, the side surface of one side of the lower fixing seat 40 in the width direction is a second inclined surface 403 which is matched with the flexible implantation detection portion 506 of the implantable biosensor 50, a first latch 404 is formed on one side of the second inclined surface 403 of the lower fixing seat 40, a second latch 405 is formed on the side surface of the lower fixing seat 40 opposite to the inclined surface 403, the surfaces of the first latch 404 and the second latch 405, which are far away from the lower fixing seat 40, are parallel to each other with the second inclined surface 403, a third stop block 406 is formed on one side of the lower fixing seat 40, which is formed with the second latch 405, the side surface of the third stop block 406, which is far away from the lower fixing seat 40, is parallel to the second inclined surface 403, the size and shape of the fixing slot 120 are matched with the external size and shape of the implantable sensor fixing device 43, and when the implantable sensor fixing device 43 receives the oblique emission force of the implanter 70, the implantable sensor fixing device is implanted into the fixing slot 120 along the oblique direction of the first latch 404, the second latch 405, and the third stop block 406, which play a role of guiding function as the oblique surface of the first stop block 404, the second latch 405, and the third stop block 406.

A groove 122 is formed in a groove wall of the fixing groove 120 adjacent to the notch 121, a clamping block 123 for limiting the position of the implantable sensor fixing device 43 is formed on the groove wall of the groove 122, one end of the clamping block 123 is fixed to the groove wall of the groove 122, and the other end of the clamping block 123 is a free end and extends into the fixing groove 120 in an inclined manner.

Specifically, a through hole 124 for passing through the half-wall needle 27 is formed in one end of the groove bottom of the fixing clamping groove 120, which is far away from the clamping block 123, the lower fixing seat 40 and the upper fixing seat 41 are respectively provided with an upper arc-shaped groove 413 and a lower arc-shaped groove 407 which are matched with the flexible implantation detection part of the implantable biosensor, the upper arc-shaped groove 413 and the lower arc-shaped groove 406 form a through hole 414 for passing through the half-wall needle 27, when in use, the half-wall needle 27 in the implantable biosensor implanter 70 wraps the flexible implantation detection part 506 of the implantable biosensor 50, the half-wall needle 27 is pushed together by a spring, and is implanted into a human body after passing through the through hole 124, then the half-wall needle 27 is retracted, and the sensor electrode is left in the human body, so that the action of implanting into the skin is completed.

Specifically, the base 100 is provided with a limiting rotation shaft hole 130, the cover 200 is formed with a limiting rotation shaft 220 matched with the limiting rotation shaft hole, in order to facilitate the insertion of the limiting rotation shaft 220, the limiting rotation shaft hole 130 can be vertically divided into a guide part and a limiting part, the aperture of the guide part of the limiting rotation shaft hole 130 is gradually increased from bottom to top, a sector-ring-shaped guide block 132 is further formed in the guide part, the radian of the guide block 132 is gradually reduced from bottom to top, during assembly, the guide part can facilitate the limiting rotation shaft 220 to enter along the guide block 132, a first limiting block 131 is formed in the limiting part of the limiting rotation shaft hole 130, the first limiting block 131 is fixedly connected with the guide block 132 and the radian of the first limiting block 131 is the same as the radian of the lower end face of the guide block 132, spacing rotation axis 220 is kept away from the one end shaping of lid 200 has the cooperation the second stopper 221 of first stopper 131, first stopper 131 is kept away from the terminal surface of lid 200 with the distance of spacing rotation axis hole 130 top surface equals second stopper 221 is close to the terminal surface of lid 200 with the distance of lid 200, the aperture size that two first stoppers 131 enclose equals the diameter size of spacing rotation axis 220, spacing rotation axis 220 inserts through certain angle and establishes in the spacing rotation axis hole 130 on base 100, spacing rotation axis 220 accessible guide part conveniently gets into spacing portion, then rotatory lid 200 makes buckle seat 212 and the locking elastic block 140 joint on the installation department.

Specifically, the number of the first limiting blocks 131 may be one or more, in this embodiment, the number of the first limiting blocks 131 is two, and the axial lines of the limiting rotation shaft holes 130 are distributed in a central symmetry manner, so that the assembly firmness is ensured and the complexity of the mold is reduced.

Specifically, a locking elastic block 140 is formed on the side surface of the mounting portion 110 far away from the fixing slot 120, one end of the locking elastic block 140 far away from the mounting portion 110 extends to be close to the edge of the base 100, a buckle seat 212 matched with the locking elastic block is formed on the side wall of the mounting cavity 210 at the corresponding position, and as the sensor electrode cannot be retained in a human body for a long time and needs to be taken out after a period of time, a pressing block 141 convenient for finger pressing is formed on the side surface of the end portion of the locking elastic block 140 far away from the mounting portion 110, so that connection between the base 100 and the cover body 200 is convenient to loosen, due to the existence of the pressing block 141 and the locking elastic block 140, a drainage hole communicated with the inside is formed on the side wall of the mounting portion 110 near the pressing block 141, and water in the mounting portion 110 is drained in time after entering water.

Specifically, a protrusion 150 is formed at an edge of the base 100 away from the limiting rotation shaft hole 130, a second engaging groove 151 is formed at a side surface of the protrusion 150, and an engaging block 230 is formed at a corresponding position of the cover 200. When the base 100 and the cover 200 are rotationally fixed, the latch 230 is inserted into the second slot 151 like a latch for enhancing the fixation of the cover 200 and the base 100, and on the other hand, the protrusion 150 can limit the cover 200 from over-rotation.

Specifically, the installation portion 110 is formed with a positioning block 160 matched with the implantable biosensor implanter 70 on the side opposite to the notch 121, and the installation portion 110 is provided with two opposite side walls adjacent to the notch 121, which are provided with clamping grooves 170 matched with each other, so as to realize detachable connection.

Specifically, the fixing slot 120 is provided with a hollow groove 125 on a groove wall opposite to the notch 121 for accommodating the implanter sliding seat 3.

Specifically, the implantable biosensor implanter 70 comprises an implanter shell 2 with an implantation port 1, a sliding seat 3 is installed in the implanter shell 2, a sensor assembly 25 is fixedly installed below the sliding seat 3, an implanter cover 12 covers the side portion of the implanter shell 2, one end of the sliding seat 3 is provided with a cavity, two opposite sides of the cavity along the length direction of the sliding seat 3 are provided with semi-through grooves 5, two opposite guide grooves 6 are formed on two sides of the cavity adjacent to the semi-through grooves 5, a separation plate 7 is fixedly connected to the groove bottom of one of the semi-through grooves 5, a gap is reserved between the side wall of the separation plate 7 and the side wall of the semi-through groove 5, a sensor fixture block 8 and a separation seat fixture block 9 are arranged on the inner wall of the separation plate 7, a fixture plate 10 is fixed on the outer wall of the separation plate 7, the position of the sliding seat fixing separation seat is moved to the back of the implanter shell, the fixture plates are arranged on two sides of the separation seat by reducing the fixture plates on one side, the fixture plates on two sides of the separation seat, the two sides of the implanter are clamped separation seat, the separation seat is clamped, the separation seat is more stable, the separation seat is further, the separation seat is not influenced, and the separation seat is more stably, and the separation seat is more.

Specifically, the injector housing 2 has a button 34 formed on an outer surface thereof.

Specifically, one end of the sliding seat 3, which is far away from the cavity, is provided with a button fixture block 19 which is matched with the button 34, and an annular groove 21 for installing the pushing spring 20 is formed below the button fixture block 19.

Specifically, the urging spring 20 is connected to the annular groove 21 at one side and connected to the implanter housing 2 at the other side.

Specifically, a sensor assembly 25 is clamped between the sensor clamping block 8 and the separating seat clamping block 9, a separating seat hook 22 is formed on the sensor assembly 25, a barb 23 is arranged at one end, away from the separating seat clamping block 9, of the separating plate 7 along the length direction of the sliding seat 3, and the barb 23 is connected with the separating seat hook 22 through a separating spring 24.

Specifically, the sensor assembly 25 includes a separation seat 26 provided with the separation seat hook 22, a half-wall needle 27 is embedded in the separation seat 26, the half-wall needle 27 is cylindrical and hollow, and a flexible implantation detection portion 506 of the implantable sensor fixing device 43 is embedded in the hollow portion of the half-wall needle 27.

In particular, the separating seat hook 22 is provided on the separating seat 26.

In particular, the guide groove 6 is used to guide the disengagement of the separation seat 26.

Specifically, the implantable sensor fixing device 43 is provided with a sensor fixing device groove 30 for matching with the sensor fixture block 8, the separation seat 26 is provided with a separation seat groove 31 for matching with the separation seat fixture block 9, and the sensor fixing device 28 is formed with a block matching with the rail shape of the guide groove 6 and provided with the sensor fixing device groove 30.

Specifically, a separation groove 32 matched with the clamping plate 10 is formed in the implanter shell 2, and the separation groove 32 is used for clamping the clamping plate 10 so as to loosen the sensor clamping block 8 and the separation seat clamping block 9.

Specifically, the bottom end of the separation groove 32 is inclined, so that the clamping plate 10 can impact the bottom edge of the separation groove 32 during the downward sliding process of the sliding seat 3.

Specifically, a mounting opening 11 is formed in a side wall of the implanter shell 2, and an implanter cover 12 is covered on the mounting opening 11.

Specifically, after the implanter housing 2 and the implanter cover 12 are closed, the push spring 20 is under compression and the release spring 24 is under tension.

Specifically, one side of the implant casing 2 close to the cavity is provided with an elastic clip 13 matched with the base 35, and the elastic clip 13 and the guide groove 6 are coplanar.

Specifically, a reinforcing rib 14 is fixedly connected between the clamping plate 10 and the separating plate 7, and the reinforcing rib 14 is used for reinforcing the clamping plate 10 and preventing the clamping plate 10 from being damaged due to impact.

Specifically, an included angle B between the clamping plate 10 and the separating plate 7 is 30-60 degrees, so that the clamping plate 10 is easier to pull out the separating plate 7 when impacting the separating groove 32.

Specifically, the outer wall of the sliding seat 3 is provided with a sliding groove 15, and the inner wall of the implanter shell 2 is provided with a clamping strip 16 matched with the sliding groove 15.

Specifically, a limiting strip 36 which is in clearance fit with the clamping plate 10 and the guide groove 6 is arranged in the implanter shell 2.

Specifically, hook-shaped chucks 18 are formed on two sides of the implanter cover 12, and a mounting hole 17 matched with the hook-shaped chucks 18 is formed in the mounting hole 11 of the implanter shell 2.

Specifically, the sensor fixture block 8 with the cross-section of separating seat fixture block 9 all is trapezoidal, the trapezoidal inclined plane in separating seat fixture block 9 cross-section is close to one side of barb 23, trapezoidal make its joint face bigger, the joint is more stable.

The working principle is as follows: in use, the implantable biosensor 50 and the electrode column 414 are placed in the lower holder 40, the upper holder 41 is then inserted into the lower holder 41 through the first latch 411, such that the electrode contacts of the electrode column 414 are exposed to the air through the electrode holes 412, the implantable sensor holder 43 is then engaged with the sensor cartridge 8 of the implantable biosensor implanter 70 through the sensor holder groove 30, the spring clip 13 of the implantable biosensor implanter 70 is then opened, the gripping surface and the gripping surface of the implanter are coplanar by fitting the electrode column into the gripping groove 170 of the base 100, thereby preventing the implanter from shaking in the oblique direction due to the oblique gripping, the pusher spring 20 of the slider 3 is pre-tensioned in the annular groove 21 of the implanter housing 2, the push button 19 on the slider 3 is released by pressing the push button 34 of the implanter housing 2, the pre-tensioned pusher spring 20 pushes the slider 3 downward to drive the sensor assembly 25 in the cavity toward the base 35, when the card 10 moves into the detachment slot 32 of the implanter housing 2, the detachment of the separator 32 hits the detachment slot 32, the detachment plate 7 and the detachment plate 26 is separated from the separator plate 26, the separator plate 26 is finally separated from the separator plate 26 and the separator plate 26, the separator plate 26 is separated from the separator plate 26, the separator plate 26 and the separator plate 24, the separator plate 26 is separated from the separator plate 24, and the separator plate 24, then, the limit rotation shaft 220 of the cover 200 is inserted into the limit rotation shaft hole 130 at a certain angle, and then the cover 200 is rotated to clamp the clamping seat 212 of the cover 200 with the locking elastic block 140 of the mounting portion 110, and simultaneously, the sealing ring 211 rotates along with the cover 200 to closely adhere to the side surface of the implanted sensor fixing device 43, so as to isolate the external liquid medium from entering, thereby achieving the sealing effect.

Although the present invention has been described in detail with reference to the foregoing embodiments, it will be apparent to those skilled in the art that modifications may be made to the embodiments or portions thereof without departing from the spirit and scope of the invention.

Claims

1. The implanting device of the implantable biosensor is characterized by comprising an implantable biosensor implanter (70), wherein an implantable sensor fixing device (43) for placing the implantable biosensor (50) which does not need to be bent is obliquely clamped at the emission end of the implantable biosensor implanter (70), the implantable sensor fixing device (43) is placed on a base (100), and the base (100) is detachably and fixedly connected with the implantable biosensor implanter (70);

the emission end of the implantable biosensor implanter (70) is an upward first inclined surface, and the surface of the implantable sensor fixing device (43) clamped with the implantable biosensor implanter (70) is a horizontal surface;

the implantable sensor fixing device (43) comprises a lower fixing seat (40) and an upper fixing seat (41) which are matched with each other, a fixing groove (401) for placing an implantable biosensor (50) which does not need to be bent is formed in the lower fixing seat (40), a first clamping groove (402) is formed in the groove wall of the fixing groove (401) along the length direction of the fixing groove, a first buckle (411) matched with the lower fixing seat (40) is formed in the side wall of the upper fixing seat (41), and an electrode hole (412) is formed from the upper surface to the lower surface of the upper fixing seat (41); the side surface of one side of the lower fixing seat (40) in the width direction is a second inclined surface (403) which is matched with a flexible implantation detection part (506) of the implantable biosensor (50), a first clamping block (404) is formed on one side of the second inclined surface (403) of the lower fixing seat (40), a second clamping block (405) is formed on the side surface of the lower fixing seat (40) opposite to the second inclined surface (403), the surfaces, far away from the lower fixing seat (40), of the first clamping block (404) and the second clamping block (405) are parallel to the second inclined surface (403), a third limiting block (406) is formed on one side, far away from the lower fixing seat (40), of the third limiting block (406) and is parallel to the second inclined surface (403);

base swivelling joint has lid (200) of mutually supporting, the shaping has on base (100) to implant ware (70) complex installation department (110) with implantation nature biosensor, seted up on lid (200) with installation department (110) complex installation cavity (210), fixed slot (120) that are used for spacing implantation nature sensor fixing device (43) are offered to the edge of installation department (110), breach (121) have been seted up on one side cell wall that fixed slot (120) are close to implantation nature biosensor (50) electrical contact, be fixed with sealing washer (211) on installation cavity (210) and the lateral wall of laminating mutually with implantation nature biosensor (50) electrical contact place side.

2. The implanting device of an implantable biosensor according to claim 1, wherein the implantable biosensor (50) comprises a blank electrode layer (501), a working electrode layer (502), a reference electrode layer (503) and a counter electrode layer (504), the blank electrode layer (501), the working electrode layer (502), the reference electrode layer (503) and the counter electrode layer (504) each comprise a circuit contact portion (505) and a flexible implantation detecting portion (506), a transition connection portion between the circuit contact portion (505) and the flexible implantation detecting portion (506) is of a bent design, and a bending angle C between the circuit contact portion (505) and the flexible implantation detecting portion (506) is 120 ° to 150 °.

3. The implanting device of an implantable biosensor as claimed in claim 2, wherein the fixing slot (120) is matched with the external dimension of the implantable sensor fixing device (43), the fixing slot (120) is provided with a groove (122) on a wall adjacent to the gap (121), a block (123) for limiting the implantable sensor fixing device (43) is formed on the wall of the groove (122), one end of the block (123) is fixed with the wall of the groove (122), and the other end is a free end and extends obliquely into the fixing slot (120).

4. The implantable device of claim 2, wherein: one end of the groove bottom of the fixed clamping groove (120), which is far away from the clamping block (123), is provided with a through hole (124) through which a half-wall needle (27) penetrates, the lower fixed seat (40) and the upper fixed seat (41) are respectively provided with an upper arc-shaped groove (413) and a lower arc-shaped groove (407), and the upper arc-shaped groove (413) and the lower arc-shaped groove (406) form a penetrating hole (414) through which the half-wall needle (27) penetrates.

5. The implantable device of claim 1, wherein: the base (100) is provided with a limiting rotation shaft hole (130) in a forming mode, a first limiting block (131) is arranged in the limiting rotation shaft hole (130) in a forming mode, the cover body (200) is provided with a limiting rotation shaft (220) matched with the limiting rotation shaft hole (130) in a forming mode, one end of the cover body (200) is far away from the limiting rotation shaft (220) is provided with a second limiting block (221) matched with the first limiting block (131) in a forming mode, the distance between the end face of the cover body (200) and the top face of the limiting rotation shaft hole (130) far away from the first limiting block (131) is equal to the distance between the end face of the cover body (200) and the cover body (200) close to the second limiting block (221).

6. The implantable device of claim 5, wherein: keep away from on installation department (110) the side shaping of fixed slot (120) has locking elastic block (140), locking elastic block (140) are kept away from the one end of installation department (110) extends to be close to the edge of base (100), have complex buckle seat (212) with it on the lateral wall of installation cavity (210) at its relevant position shaping.

7. The implantable device of claim 6, wherein: a protruding block (150) is formed at the edge of the base (100) far away from the limiting rotary shaft hole (130), a second clamping groove (151) is formed in the side face of the protruding block (150), and a clamping block (230) matched with the cover body (200) is formed in the corresponding position of the cover body.