CN109998555B

CN109998555B - Receptor physiological parameter measurement system

Info

Publication number: CN109998555B
Application number: CN201910359499.8A
Authority: CN
Inventors: 钱成; 肖林春; 卞庆祥
Original assignee: Diascience Medical Co Ltd
Current assignee: Diascience Medical Co Ltd
Priority date: 2019-04-30
Filing date: 2019-04-30
Publication date: 2023-12-15
Anticipated expiration: 2039-04-30
Also published as: AT17918U1; CN109998555A; ES1283120U; WO2020221330A1; ES1283120Y; DE202020005632U1; CZ36027U1

Abstract

The invention discloses a receptor physiological parameter measuring system which is divided into an implanter, a sensor base device and a transmitter, wherein the sensor base device is fixed on the skin of a receptor, the implanter is arranged on the sensor base device and is used for implanting a sensor part into subcutaneous tissue of the receptor, and the transmitter can be arranged on the sensor base device after the implanter is disassembled, so that dynamic physiological parameter monitoring can be carried out within a certain time period. Compared with the prior art, the receptor physiological parameter measuring system can firstly reduce the puncture pain of a patient to the greatest extent, monitor the physiological parameter in a certain time period and master the level change of the physiological parameter of the patient more accurately. Secondly, after the parts of the system are reasonably combined, most parts can be reused for many times, so that the material waste is reduced, the use cost of a user is greatly reduced, and the potential harm to the environment is reduced.

Description

Receptor physiological parameter measurement system

Technical Field

The invention relates to a system for quickly implanting a biosensor into receptor tissues, repeatedly using and measuring physiological parameters of receptors, belonging to the technical field of wearable medical appliances.

Background

Some physiological diseases have long disease course and prolonged illness state, and the physiological parameters of the receptor need to be monitored in real time so as to better track treatment. Such as diabetes, require real-time monitoring of the blood glucose of the subject. Accurate blood glucose self-monitoring is a key for realizing good blood glucose control, is beneficial to evaluating the degree of glucose metabolic disturbance of diabetics, and makes a blood glucose reducing scheme, and simultaneously reflects the blood glucose reducing treatment effect and guides the adjustment of the treatment scheme. Currently, the most widely used blood glucose meter is available, and the patient needs to collect finger peripheral blood from himself to measure the blood glucose level at that time. One of the drawbacks of this method is that it is not possible to know the change in blood glucose level between two measurements, and the patient may miss blood glucose peaks and valleys, thereby causing complications and causing irreversible damage to the patient; secondly, the finger tip puncture blood sampling is carried out for a plurality of times every day, which causes great pain to diabetics. In order to solve the puzzles, a method for continuously monitoring the blood sugar of a patient is needed, so that the patient knows the blood sugar condition of the patient in real time and can take measures in time, thereby effectively controlling the illness state, preventing complications and obtaining higher life quality.

In order to solve the above problems, the technical staff developed a continuous blood glucose monitoring technology capable of being implanted into subcutaneous tissue to continuously monitor subcutaneous glucose, the technology comprises a sensor electrode penetrating into subcutaneous tissue, wherein the electrode generates an electric signal when the interstitial fluid of a patient and glucose in the body react, the electric signal is converted into blood glucose readings through a transmitter, the blood glucose readings are transmitted to a wireless receiver every 1-5 minutes, and corresponding blood glucose data are displayed on the receiver and a map is formed for reference of the patient and doctors.

Currently, subcutaneously implantable continuous blood glucose monitoring sensors typically employ very thin wires or polymer sheets as carriers. The wire may be a platinum coated stainless steel wire, for example, the use of platinum electroplated onto a stainless steel wire having a diameter of 0.16mm to 0.25mm as a carrier for the sensor electrodes has been disclosed in the literature. Because the stainless steel wire has sufficient hardness, the sensor electrode can directly penetrate the skin into the tissue without the aid of an auxiliary tool. However, the implantation method has the defects of larger wound, strong pain feeling and strong abnormal feeling after subcutaneous implantation due to larger hardness of the sensor electrode, and still causes great trouble to diabetics.

In order to reduce the pain caused by the sensor electrode, the technician changes the metal wire carrier into a relatively soft platinum wire or a nickel wire coated with platinum, or adopts a polymer sheet as the carrier. However, since the carrier has insufficient rigidity, it cannot directly pierce the skin, and thus it is necessary to implant a small and soft sensor electrode into subcutaneous tissue by means of an auxiliary implantation tool to reduce the sense of presence or abnormal sense after subcutaneous implantation.

Currently, many auxiliary implantation tools are either manual or semi-automatic. Because of inconsistent implantation speed and force of manual implantation, the speed is low, and the implantation process takes a long time. On one hand, the deviation value of the sensor after implantation is larger, and on the other hand, pain of a patient is increased.

On the other hand, the traditional dynamic blood sugar transmitter mainly comprises three parts, namely a button cell, a circuit board and a plastic package shell. Because of waterproof requirements and volume limitations, button cells and circuit boards are generally placed in the emitter together, and are generally molded integrally, the emitter cells are not replaceable. When the battery life is over, the transmitter is essentially unusable. From the cost perspective, the cost of the plastic package shell and the circuit board of the transmitter is far greater than the cost of the battery, and the service lives of the plastic package shell and the circuit board of the transmitter are also far greater than the service life of the battery. From the environmental point of view, the manufacturing and disposal processes of the circuit board may bring potential harm to the environment. Therefore, the mode can greatly waste the circuit board and the plastic package shell, and increase the material cost and the resource waste.

In order to solve the above problems, on the one hand, a proper way is needed to make the small and soft biosensor electrode penetrate into the skin with the help of the auxiliary implantation tool at a very fast speed, so that pain is reduced to a very low level, and the sensor electrode is left under the skin, so that the implantation actions are performed in the set needle tube, and the deviation risk caused by manual operation is reduced. On the other hand, a proper mode is needed to separate the battery from the emitter, so that the service life of the circuit board and the plastic package shell is not limited by the service life of the battery, and the method is very significant in reducing cost and waste.

Disclosure of Invention

The technical problem to be solved by the invention is to provide a receptor physiological parameter measuring system aiming at the defects of the prior art.

In order to solve the technical problems, the invention adopts the following technical scheme:

a subject physiological parameter measurement system comprising an implanter, a sensor mount device, and a transmitter, both mountable to the sensor mount device;

the implanter comprises an implanter upper cover, an implanter lower cover, a button, a bracket, a thimble seat, a puncture needle seat, a guide needle seat, a needle return spring, a driving spring, a thimble, a puncture needle, a guide needle and a guide limiting block, wherein the implanter upper cover and the implanter lower cover form an outer shell, the button is positioned on the implanter upper cover, the bracket, the thimble seat, the puncture needle seat and the guide needle seat are all arranged in the outer shell in a matched manner, and the front end of the outer shell is connected with a sensor base device;

The support is fixed in the outer shell, the support is of a cylindrical structure with one end open, the opening of the support faces the sensor base device, the upper part of the support is a long cylinder, the front end of the support faces the sensor base device, the front end of the support is provided with an elastic clamping rib which is buckled in the support inwards, the elastic clamping rib of the support is used for limiting the guide needle seat, the upper part of the rear end of the support is provided with a support buckle used for clamping the ejector needle seat, and the outer side of the support is provided with a support boss which can be buckled with the guide limiting block and a limiting elastic buckle used for limiting the movement of the ejector needle seat;

the device comprises a sensor base device, a long cylinder, a sleeve, a driving spring, an elastic card, a button, a rectangular hole, a thimble boss and a thimble boss, wherein the thimble base is of a cylindrical structure with two open ends, the thimble base is movable in a bracket, the upper part of the thimble base is provided with the sleeve, the long cylinder penetrates through the sleeve, the edge of the front end of the sleeve, which faces the sensor base device, is provided with the annular edge, the sleeve is internally provided with the driving spring for pushing the thimble base, the sleeve is also provided with the elastic card which is buckled with the bracket in a buckling manner, the button can stir the elastic card, the two sides of the thimble base are provided with the rectangular hole, the front end of the thimble base is a bevel end, the upper part of the rear end of the thimble base is provided with the thimble boss, and the thimble is positioned in the thimble boss, and the inner top position of the thimble base cylindrical structure is provided with ribs along the length direction;

The two sides of the puncture needle seat are provided with inclined plane brackets, the end parts of the inclined plane brackets are provided with elastic pins which can be clamped into rectangular holes, the upper part of the puncture needle seat is provided with sliding grooves which are buckled into ribs of the ejector needle seat, the puncture needle seat slides in the ejector needle seat along the ribs, and the puncture needle is positioned in the puncture needle seat;

the guide needle seat is of a cylindrical structure with two open ends, the side part of the guide limit block is provided with a clamping hook which is buckled with the boss of the bracket, the middle of the guide limit block is provided with a guide cylinder which penetrates through the guide needle seat, one end of the guide needle seat, which faces the sensor base device, is provided with a limit boss which is buckled with the elastic clamping rib of the bracket, the edge of the guide needle seat, which faces away from one end of the sensor base device, is provided with a ring edge, the guide needle seat is internally provided with a needle return spring which pushes the guide needle seat to move away from the sensor base device, the guide needle seat is preset in the top needle seat and can move through the top needle seat, the upper part of the guide needle seat is provided with a release boss, the movement of the guide needle seat can extrude the inclined plane bracket through the release boss to enable the elastic bolt to be separated from the rectangular hole, the side part of the guide needle seat is also provided with an unlocking boss which can prop open the limit elastic buckle, the upper part of the guide needle seat is provided with a guide needle boss, the guide needle boss can be connected with the sensor base device, and the guide needle is positioned in the guide needle boss;

The sensor base device comprises a base and an adhesive tape, and the base is positioned on the adhesive tape; the upper part of the base is provided with an opening, a battery groove and a groove are formed in the base, a battery and a battery cover are arranged in the battery groove, a rotating seat is arranged in the groove, one side of the rotating seat, which is close to the battery groove, is hinged in the groove, a silica gel seat is arranged in the rotating seat, a pair of conductive rubbers is arranged in the silica gel seat, a sensor is arranged to penetrate through the silica gel seat and the rotating seat, the sensor can penetrate through the two conductive rubbers, an opening is formed in one side, close to the battery groove, of the groove, a hole is formed in the adhesive tape, and the sensor can penetrate through the opening and the hole of the adhesive tape;

the transmitter comprises a plastic package shell and a circuit board assembly, wherein the plastic package shell is covered on the base, the circuit board assembly is arranged inside the plastic package shell, and the circuit board assembly is provided with four conductive pins which can contact the anode and the cathode of the battery and two conductive rubbers.

As a further preferable scheme, a button hole is formed in the upper cover of the implanter, and the button is positioned in the button hole; the button hole is internally provided with an annular structure, two L-shaped notches are formed in the annular structure, the shorter grooves of the two L-shaped notches face into the upper cover of the implanter, and the longer grooves are oppositely arranged; the button bottom surface has a pair of button boss, and button boss accessible button's rotation unscrews breach, and the button bottom surface still is provided with the triggering muscle that can stir the elasticity card, and a triggering muscle corresponds an elasticity card, and the button boss is in when unscrewing the breach state, triggers the muscle and is in elasticity card position.

As a further preferable scheme, the rear end of the lower cover of the implanter is provided with a deep groove, a button frame is arranged in the deep groove, a button frame cylinder is arranged on the button frame, a cylinder hole is arranged at the bottom of the button, the button frame cylinder is arranged in the cylinder hole, and a button spring is arranged in the cylinder hole around the button frame cylinder.

As a further preferable scheme, the silica gel seat is provided with a first conductive rubber hole and a second conductive rubber hole, and the two conductive rubbers are respectively arranged in the first conductive rubber hole and the second conductive rubber hole; the silica gel seat is internally provided with two square holes, the two conductive rubbers and the two square holes are distributed in a straight line, and the sensor penetrates through the two conductive rubbers.

As a further preferable scheme, a semicircular hole is respectively formed in two sides in the groove, a tough extending rod is respectively arranged on two sides of the end part of the rotating seat, a cylindrical shaft is arranged on the outer side of the extending rod, and the cylindrical shaft is arranged in the semicircular hole to rotate.

As a further preferable scheme, an electrode adapter is respectively arranged on the anode and the cathode of the battery, an electrode connecting piece is arranged on each electrode adapter, two round holes are formed in the battery cover, one round hole corresponds to one electrode connecting piece, and the electrode connecting pieces penetrate through the round holes and are arranged outside the battery cover.

As a further preferable scheme, the four conductive pins on the circuit board assembly are two battery conductive pins and two rubber conductive pins, the two battery conductive pins are respectively connected with an electrode connecting piece, and the two rubber conductive pins are respectively connected with one conductive rubber.

As a further preferable scheme, the end part of the base is provided with a base buckle opening, and the end part of the plastic package shell is provided with an edge boss inserted into the base buckle opening; the side part of the plastic package shell is provided with a shell clamping groove, and the inner side wall of the groove is provided with an elastic buckle clamped into the shell clamping groove.

As a further preferable scheme, a circle of edges of the battery groove is provided with a sealing strip, and a circle of edges of the silica gel seat is provided with a rib.

Compared with the prior art, the receptor physiological parameter measuring system solves the problem that a diabetic patient needs to puncture and collect blood by fingertips for many times every day, monitors blood sugar in a certain time period through the sensor electrode penetrating into subcutaneous tissue, can relieve the puncture pain of the patient to a greater extent, and can master the change of the blood sugar level of the patient more accurately. Secondly, the small and soft sensor electrode is implanted into subcutaneous tissue by means of the auxiliary implantation tool, so that the problems of pain and foreign body sensation brought by the sensor electrode implanted into a receptor are solved. Thirdly, the automatic implanter which is arranged linearly can complete the actions of implanting the sensor electrode and withdrawing the needle at a higher speed, thereby greatly relieving the puncture pain of a patient. Fourth, reasonable spare part combination for most part can reuse many times, reduces the material extravagant, reduces user's use cost by a wide margin, reduces and brings potential harm to the environment.

Drawings

FIG. 1 is a schematic diagram of the working principle of the present invention;

FIG. 2 is a schematic diagram of the structure of the present invention;

FIG. 3 is a cross-sectional view of the implant in an initial state;

FIG. 4 is a schematic view of the sensor base assembly in operation;

FIG. 5 is an exploded view of an implanter;

FIG. 6 is a schematic view of the upper cover structure of the implanter;

FIG. 7 is a schematic view of the lower cover structure of the implanter;

FIG. 8 is a schematic diagram of a button structure;

FIG. 9 is a cross-sectional view of a stent;

FIG. 10 is a schematic view of the internal structure of the bracket;

FIG. 11 is a schematic view of the structure of the hub;

FIG. 12 is a schematic view of the internal structure of the puncture needle holder and the guide needle holder;

FIG. 13 is a schematic cross-sectional view of a puncture needle holder and a guide needle holder;

FIG. 14 is an exploded view of the transmitter;

FIG. 15 is an exploded view of a sensor base assembly;

FIG. 16 is a cross-sectional view of a silicone base;

FIG. 17 is a schematic view of the structure of the base;

fig. 18 is a schematic view of a battery cover structure;

FIG. 19 is a schematic view of the structure of the rotating base and the silica gel base;

fig. 20 is a schematic diagram of an electrical system module according to the present invention.

Detailed Description

The inventive method of the present invention is described and illustrated in detail below in conjunction with specific examples. The content of which is to be interpreted as an explanation of the invention and not to limit the scope of the invention.

Fig. 1 is a schematic diagram of the working principle of the present invention. With the single use implant 200, the sensor 301 is partially implanted into the recipient tissue 100, with the outer recipient portion of the sensor 301 in electrical contact with the emitter 400. After the transmitter detects the bio-signal of the sensor 301, the signal is converted into a physiological parameter and sent to the receiver 500 of the user by means of wireless transmission.

The physiological parameter measuring system is structurally divided into 3 parts: an implanter 200, a sensor mount apparatus 300, and a transmitter 400, as shown in fig. 2.

As shown in fig. 3, in an initial state, the sensor base assembly 300 and the implanter 200 are coupled together by frictional resistance between the guide needle 213 and the silicone mount 310, maintaining their initial positions; the biosensor electrode is mounted inside the implanter, maintaining its initial position by frictional resistance. The transmitter 400 is now in an unused state.

As shown in fig. 4, after implantation, the sensor 301 is partially advanced into the recipient tissue and partially retained in the sensor mount assembly 300. After the transmitter 400 is installed, the transmitter "reads" the signal on the biosensor and converts the signal into a physiological parameter, and sends the physiological parameter to the receiver 500, where the receiver 500 may be a mobile phone, an operator, or even a cloud.

The implant device 200 is described in detail below;

the implanting device 200 is used for implanting a sensor 301 into a recipient tissue, as shown in fig. 5, structurally mainly comprises an upper implanter cover 201, a lower implanter cover 202, a button 203, a bracket 204, a top needle holder 205, a puncture needle holder 206, a guide needle holder 207, a needle return spring 208, a driving spring 209, a thimble 211, a puncture needle 212, a guide needle 213 and a guide stopper 214, wherein the upper implanter cover 201 and the lower implanter cover 202 form an outer shell, the bracket 204 and the guide stopper 214 are fixed in the outer shell, the top needle holder 205, the puncture needle holder 206 and the guide needle holder 207 are all positioned in the bracket 204 and the guide stopper 214, and the top needle holder 205 mainly drives the thimble 211 to move forwards to trigger the guide needle holder 207 to move reversely, so that the implanting process of the sensor 301 is formed.

As shown in fig. 6, a T-shaped structure 2011 (limit structure) is disposed in the upper cover 201 of the implanter, and is used for limiting the guide needle seat 207 and preventing the guide needle seat from shaking, so that the puncture needle can have a relatively straight puncture into human tissue, and pain caused by shaking is reduced.

The implant upper cover 201 is internally provided with a stop 2012 which cooperates with a stop 2041 on the bracket 204 to provide sufficient strength to the bracket stop on the one hand and to prevent displacement of the bracket under the influence of the drive spring 209 on the other hand.

The front end of the implanter upper cover 201 has a button hole 2013 for receiving the button 203. The button can rotate in the round hole and move up and down.

The button hole 2013 has an L-shaped notch 2014 on both sides, and the notch 2014 can be matched with a button boss 2031 on the button 203. In one aspect, the notch may limit movement of the button to the outside of the implanter cover 201 by the button boss 2031. On the other hand, the L-shaped structure can provide a locking and unlocking function. In the initial state, the button boss 2031 on the button 203 is located at the innermost side of the L-shape. The button is limited to rotate in only one direction and cannot be pressed. In this case in the "locked" state. Functions to prevent false triggering of the button 203. When the button is rotated by the user by a certain angle, the button boss 2031 is located at the open end of the L-shape. In this case in the "unlocked" state, the button may be pressed.

The L-shaped notch 2014 has a lock tab 2015, and when the button tab 2031 on the button 203 is in the "locked" position, there is some interference between the lock tab 2015 and the button tab 2031, so the button 203 cannot easily rotate to the "unlocked" position. It is possible to prevent the false triggering of the button 203 in the case of transportation, picking and placing, and the like.

The lower implanter cover 202, as shown in fig. 7, has a base recess 2021 at the bottom, the base recess 2021 being used to mount the sensor base 302, and the sensor base assembly 300 and the implanter 200 are connected together by frictional resistance between the guide pin 213 and the silicone mount 310 to maintain their initial positions before the sensor 301 is implanted.

A triangular rib 2022 is provided in the base recess 2021, and is used to limit the base and prevent the base from moving.

A rectangular opening 2023 is arranged in the base groove 2021, and the opening is moderate in size; in the initial state, the opening allows the swivel seat 309 in the base to pass, but restricts upward movement of the base.

The front and back of the inner part of the lower cover 202 of the implanter are provided with limiting plates 2024, and the limiting plates 2024 are matched with the planes of the end part and the tail part of the bracket 204. After the bracket is installed in the lower cover, the front and rear of the bracket are limited by the limiting piece, and the upper part of the bracket is limited by the upper cover 201 of the implanter, so that the bracket is fixed in the upper and lower covers of the implanter and cannot move.

The limiting piece 2024 also has a function that when the implant is performed, the top needle seat and the puncture needle seat move forward, and the limiting piece is used for limiting the advancing distance of the puncture needle seat and the top needle seat so as to ensure that the implant length cannot exceed a set value.

The front end of the inner part of the lower cover 202 of the implanter is provided with a positioning slot 2025 for positioning the guiding stopper 214.

As shown in fig. 7, the guide stopper 214 is positioned in front of and behind the positioning groove 2025 in the lower cover 202 of the implanter, and is positioned in the lower position of the guide holder 207 and the lower cover 202 of the implanter, respectively. The guide stopper is provided with a long guide cylinder 2141, which can prevent the needle return spring 208 from twisting during installation and operation, on the one hand, so that the guide needle holder 204 cannot normally move. On the other hand, the cylinder may provide guidance to the guide needle hub when the guide needle hub 204 is retracted.

The implant lower cap 202 has a deep groove 2026 at the rear thereof, the deep groove 2026 being used to limit the button frame 215 to prevent displacement of the button frame 215 when subjected to a force.

As shown in fig. 8, the button 203 has two trigger ribs 2032 which, when the button is depressed, are capable of toggling the resilient tab 2051 of the hub to trigger the operation of the implant.

The button 203 has a cylindrical hole 2033, and the height of the cylinder is set shorter than that of the triggering rib 2032, thereby ensuring that the triggering rib can work normally. The cylindrical hole is used to store the button spring 210 and is engaged with the button frame cylinder 2151 of the button frame 215. When the driving force of the push button spring is removed, the push button returns to the original position under the action of the spring.

The button 203 has a ridge 2033 on its upper surface to increase friction so that the finger can more easily turn the button.

The button 203 has a triangular arrow 2034 on its upper surface. The arrow corresponds to the "lock" and "unlock" flag 2016 of the cover to indicate the state of the button. In the initial state, the triangular arrow 2034 faces the "lock" flag. When the button is rotated through a certain angle, the triangular arrow 2034 faces the "unlock" label. At this point the button can be depressed, triggering the operation of the implanter.

As shown in fig. 9, the upper portion of the support 204 has a long cylinder 2042, which cooperates with a sleeve 2052 on the upper portion of the top needle seat 205 to provide guidance for the movement of the top needle seat, preventing the top needle seat and the puncture needle seat from shaking, so that the puncture needle can have a relatively straight puncture into human tissue, and pain caused by shaking is reduced.

In addition, the long cylinder 2042 serves to position the drive spring 209, preventing the drive spring from twisting during installation and operation, resulting in the hub 205 not being able to move normally.

As shown in fig. 10, the upper rear section of the bracket 204 has two bracket catches 2043, and the bracket catches 2043 are matched with the elastic card 2051 of the ejector pin seat 205. When the ejector pin seat is pulled backwards during installation, and when the ejector pin seat is pulled to a preset position, the ejector pin seat elastic card 2051 can be clamped by the bracket buckle 2043. Although the ejector pin seat has a trend of forward movement under the action of the driving spring, the ejector pin seat keeps a static state because the elastic card of the ejector pin seat is clamped by the bracket buckle.

The middle front section of the bracket 204 has two bent bracket elastic clamping ribs 2044 which cooperate with the limiting boss 2071 of the guide hub 207 to limit the rearward movement of the guide hub.

The middle front section of the bracket 204 is provided with two bracket bosses 2045, and the bracket bosses 2045 are matched with the hooks 2142 of the guide limiting block 214, so that the guide limiting block 214 and the bracket 204 are integrated. Therefore, the needle return spring 208 is in a preloaded state under the restraint of the bracket 204, the guide stopper 214, and the guide hub 207. When the bent support elastic clamping ribs 2044 of the support are triggered, the guide needle seat is retreated under the thrust of the needle return spring 208.

The middle side of the bracket 204 is provided with 2 limiting elastic buckles 2046, the top of each buckle is provided with an inclined plane, and when the ejector pin seat 205 moves forwards, the inclined planes of the elastic buckles are outwards opened under the action of the ejector pin seat, so that the ejector pin seat passes through. When the ejector pin seat reaches a preset position, the elastic buckle rebounds and clamps the ejector pin seat through the straight surface, so that the ejector pin seat cannot retreat. The structure is favorable for keeping the position of the needle holder in the needle returning process and preventing the sensor electrode from being displaced after being implanted in place.

As shown in FIG. 11, the top hub 205 has a rectangular aperture 2053 on either side that mates with the resilient latch 2061 on the puncture needle hub 206. After the puncture needle stand is put in place, the elastic buckle is clamped into the rectangular hole of the top needle stand, so that the puncture needle stand and the top needle stand are kept relatively fixed. The ejector pin seat can move forward together with the puncture pin seat to puncture the receptor tissue when moving forward under the action of the driving spring 209.

The front section of the top needle seat 205 has a bevel end 2054 on each side, and when the top needle seat moves to a preset position, the bevel will expand the two bent elastic support blocking ribs 2044 of the support 204 outwards, so as to release the guide needle seat 207 blocked by the support, and the guide needle seat is retracted backwards under the action of the needle retracting spring 208.

The tail of the ejector pin seat 205 is provided with an ejector pin boss 2055, the ejector pin boss 2055 is matched with the puncture pin seat 206, and when the puncture pin seat is retracted to be contacted with the ejector pin boss 2055, the puncture pin seat can be retracted together with the ejector pin seat.

The right end of the thimble boss 2055 is provided with a thimble bonding hole 2056, and the thimble bonding hole 2056 is used for bonding the thimble 211, and the bonding mode is not limited. The left end of the thimble boss 2055 is provided with a thimble glue overflow groove 2057 which can prevent glue from overflowing, thereby affecting the matching and movement.

As shown in fig. 12, there are 2 elastic pins 2061 on two sides of the puncture needle holder 206, and after the puncture needle holder is put in place, the puncture needle holder is snapped into the rectangular hole 2053 of the top needle holder 205 by elastic snap, so that the puncture needle holder and the top needle holder are kept relatively fixed.

The elastic latch 2061 has a slant bracket 2062, which cooperates with the upper release boss 2072 of the guide hub 207, and when the guide hub is retracted to a preset position, the release boss 2072 of the guide hub 207 will tighten the two bent elastic latch ribs of the puncture hub inwards, so as to separate the puncture hub from the ejector hub.

The top of the puncture needle holder 206 is provided with a sliding groove 2063 which is matched with the rib 2058 of the top needle holder, so that the puncture needle holder keeps a preset track to move, and the pain caused by shaking is reduced.

The left side of the puncture needle holder 206 has a puncture needle adhesive hole 2064, and the puncture needle adhesive hole 2064 is used for adhering the puncture needle 212, but the adhering manner is not limited. A puncture needle glue overflow groove 2065 is arranged on the right side to prevent glue from overflowing, thereby affecting the matching and movement.

As shown in fig. 13, a guiding circular hole 2073 is formed in the middle of the guiding needle holder 207, the tail of the guiding circular hole 2073 is reduced or closed for installing the needle return spring 208, and the needle return spring is prevented from twisting during installation and operation, so that the guiding needle holder cannot normally move.

The upper part of the guide needle holder 207 is provided with a release boss 2072, and when the guide needle holder is retracted to a preset position, the release boss 2072 of the guide needle holder 207 will tighten the two bent elastic clamping ribs 2061 of the puncture needle holder 206 inwards, thereby separating the puncture needle holder from the top needle holder 205.

The unlocking boss 2074 is arranged on the upper right side of the limiting boss 2071 on two sides of the guide needle seat 207, when the guide needle seat moves to a preset position, the unlocking boss 2074 is contacted with the limiting elastic buckle 2046 of the support, and the elastic buckle of the support is outwards opened under the action of the unlocking boss 2074, so that the top needle seat 205 is released, and then the top needle seat is driven by the guide needle seat and the puncture needle seat to be retracted together.

The guide hub 207 has a guide pin boss 2075 on the front which engages the hub 309 in the base to limit movement of the hub before implantation. After implantation, the guide needle seat is retracted, and the limit of the rotating seat is released.

The left side of the guide pin boss 2075 has a guide pin bonding hole 2076, and the guide pin bonding hole 2076 is used for bonding the guide pin 213, the bonding mode is not limited. The right side is provided with a guide pin glue overflow groove 2077 which can prevent glue from overflowing, thereby affecting the matching and movement.

The initial state before use is that the clamping hook 2142 of the guide limiting block 214 is mutually buckled with the support boss 2045 of the support 204, the support 204 is limited and fixed inside the upper cover 201 of the implanter and the lower cover 202 of the implanter, the support elastic clamping rib 2044 of the support 204 clamps the limiting boss 2071 of the guide needle base 207, the support clamping buckle 2043 clamps the elastic clamping piece 2051 of the top needle base 205, the elastic bolt 2061 of the puncture needle base 206 is clamped into the rectangular hole 2053 on the side surface of the top needle base 205, so that the puncture needle base 206 is opposite to the top needle base 205 as a whole, at this moment, the driving spring 209 in the sleeve 2052 is in a compressed state, the return needle spring 208 in the top needle base 205 is in a compressed state, the front end of the puncture needle 212 is positioned in the guide needle 213, the top needle 211 is positioned at the rear end of the puncture needle 212, the sensor 301 is positioned in the puncture needle 212, the diameter of the top needle 211 is slightly smaller than the inner diameter of the puncture needle 212, the top needle 211 is the same as the sensor 301, and the sensor 301 is a flexible electrode needle body;

When in use, the sensor base device 300 is placed on human skin, the button 203 is pressed down, the inclined surface of the elastic card 2051 is pressed by the triggering rib 2032 of the button 203, the elastic card 2051 is stirred, the elastic card 2051 is separated from the bracket buckle 2043, the driving spring 209 releases the compression force to drive the top needle seat 205 and the puncture needle seat 206 to move forwards, the puncture needle 212 on the puncture needle seat 206 is inserted into the skin of a receptor through the guide needle 213, the top needle seat 205 slides over the inclined surface of the limit elastic buckle 2046 along with the forward movement of the top needle seat 205 until the end part of the top needle seat 205 is blocked by the straight surface of the limit elastic buckle 2046, the inclined surface end 2054 of the top needle seat 205 is impacted on the bracket elastic buckle rib 2044, the elastic clamping rib 2044 of the support breaks away from the limiting boss 2071 of the guide needle base 207, the needle return spring 208 releases the compression force to drive the guide needle base 207 to move reversely, the release boss 2072 on the guide needle base 207 extrudes the inclined support 2062 of the puncture needle base 206, the elastic plug 2061 breaks away from the rectangular hole 2053, the guide needle base 207 drives the puncture needle base 206 to move reversely together, the puncture needle 212 breaks away from a receptor, the guide needle 213 breaks away from the silica gel base 310, and the needle holder 205 does not move reversely at the moment, so that the needle 211 always acts on the sensor 301 in the puncture needle 212, the puncture needle 212 breaks away from the receptor, and the sensor 301 remains in the receptor;

In order to avoid that after the puncture needle holder 206 is pulled out, part of the sensor 301 is exposed out of the silica gel holder 310, so that the thimble 211 should extend into the silica gel holder 310, and when the guide needle 213 and the puncture needle holder 206 are pulled out, the end of the sensor 301 is not exposed;

when the guide needle seat 207 moves to the limit elastic buckle 2046, the unlocking boss 2074 expands the limit elastic buckle 2046, and the guide needle seat 207 also impacts the bottom of the ejector needle seat 205 at the moment, so that the ejector needle seat 205 can be driven to move reversely for a small distance, the ejector needle 211 extending into the silica gel seat 310 is ensured to be pulled out, and the implanter 200 can be removed at the moment, and the emitter 400 is installed.

As shown in fig. 14, the hardware of the transmitter 400 includes a circuit board assembly 401 and a plastic package housing 402. The emitter has a size of 32mm 16mm 5mm, and is convenient to be attached to the skin of a recipient and carried about after being mounted in the sensor base device 300.

The circuit board assembly 401 includes four conductive pins, typically of conductive metal, preferably brass. The conductive pins exit from the plastic enclosure 402 flush with the bottom surface of the plastic enclosure. When the transmitter 400 is snapped into the sensor mount assembly 300, the conductive pins are connected to the sensors S+, S-and the battery V+V-, respectively. The battery 304 in the sensor base 300 supplies power to the transmitter 400, and the transmitter 400 can convert the signal value measured from the sensor 301 into a corresponding physiological parameter and send the physiological parameter to the user receiving end 500.

The plastic package housing 402, except for 4 conductive pins, completely encapsulates the circuit board assembly, and can achieve a waterproof effect. The left side of the plastic package shell is provided with an edge boss 4021, two sides of the plastic package shell are respectively provided with a shell clamping groove 4022, and when the emitter is arranged on the sensor base, the edge boss 4021 and the shell clamping groove 4022 can fix the emitter 400 on the base

As shown in fig. 15, the sensor base assembly 300 basically includes a battery 304 and a sensor 301. Wherein the battery 304 and the transmitter 400 are connected by electrical contacts V + and V-. The sensor 301 and the transmitter 400 are connected by an electrical contact S + S-.

The sensor base device 300 further comprises a sensor 301, a base 302, a rubberized fabric 303, a battery 304, a battery adapter 305, an electrode connector 306, a battery cover 307, a waterproof seal 308 of the battery connector, a rotating base 309, a silicone base 310, conductive rubber and the like 311.

The battery adapter 305 may be a metal member such as nickel strap. The battery adapter 305 is connected to the battery 304 and the battery connector 306 by welding or the like.

And the battery 304 is provided with insulating paper outside to prevent the conduction of the anode and the cathode of the battery.

The battery connector 306 is placed on the battery adapter 305 and is compressible by the mounting of the battery cover 307.

The battery connector 306 is resilient and can be in resilient electrical connection with the transmitter. Preferably, the battery connector 306 may be a spring pin with a spring inside that depresses the contact of the battery connector when the transmitter 400 is installed, thereby ensuring reliable contact between the battery connector contact and the transmitter contact.

The surface of the base 302 is provided with a circle of waterproof sealing ring 308, and the waterproof sealing ring can be made of elastic materials such as silica gel, TPE, TPU and the like. The waterproof sealing ring can be directly injection molded on the base, and also can be bonded on the base through later stage. The waterproof sealing ring is trapezoidal or triangular, so that the emitter can be well arranged, and the waterproof sealing ring can be well waterproof. When combined with the bottom plane of the emitter, the waterproof effect can be achieved, and the waterproof grade can reach IPX7.

In the unused state, the transmitter 400 is not yet mounted on the sensor mount device 300, and therefore, the transmitter 400 is in the power-off state, and the battery 304 is not consumed. When in use, the transmitter 400 is snapped onto the sensor mount 300, and the battery on the sensor mount 300 provides power to the transmitter 400 through an electrical connection. When used, the transmitter is removed and the battery 304 is discarded along with the sensor.

As shown in fig. 16, the sensor 301 is implanted in subcutaneous tissue of an organism for sensing a raw signal of an analyte. Sensor 301 includes at least 1 working electrode and one reference electrode. The working electrode and the reference electrode S + S-are electrically connected by a battery lead 4011 and a rubber lead 4012 of the emitter 400, respectively, through the conductive rubber 311.

The base 302 is fixed to the skin of the subject by a non-woven fabric adhesive tape 303, and is fixedly connected to the transmitter 400.

As shown in fig. 17, the base 302 has a battery slot 3021 of 12mm in the middle for receiving the battery 304. The positive and negative electrodes of the battery are connected to the battery connector 306 by the battery adapter 305 and then led to the outer surface of the base by the battery connector.

The base 302 is provided with a base snap opening 3023 at the end. The top of the opening is a plane, and the bottom of the opening is provided with an inclined plane with a certain angle. The top surface is adapted to mate with the edge boss 4021 of the emitter 400 to limit the emitter. The bottom bevel facilitates emitter installation.

The base 302 has a recess 3024 in the right portion for receiving the swivel 309. When the sensor 301 is implanted, the rotating seat rotates clockwise by a certain angle and finally is attached to the bottom surface of the groove. The recess 3024 has an opening 3025 in the lower left side through which the sensor 301 can pass.

Two sides of the groove 3024 are provided with a semicircular hole 3026, which cooperates with the cylindrical shaft 3092 of the swivel 309 so that the swivel can rotate along the axis of the hole.

A bevel is provided above the semicircle orifice 3026, which is snapped into the semicircle orifice for facilitating the rotation of the seat cylinder shaft.

The elastic buckles 3027 are arranged on two sides of the base 302 and are used for being matched with the housing clamping grooves 4022 on two sides of the emitter, when the emitter is installed, the elastic buckles on two sides of the base are outwards opened, and after the emitter is installed in place, the elastic buckles retract. The bottom surface of the elastic buckle is blocked with the clamping groove of the emitter to limit the movement of the emitter.

As shown in fig. 18, a battery cover 307 is provided for cooperating with the base 302 to fix the battery connector 306 and the battery 304. A battery cover recess 3071 is provided in the middle of the battery cover 307 for accommodating the battery 304. The battery connector is fixed by the cooperation of 2 cylindrical steps 3022 corresponding to the bottom surface of the base, wherein the two ends of the battery connector are respectively provided with a cylindrical hole step surface 3072. The 2 circular holes 3073 in the top of the battery cover 307 allow the elastic members of the battery connector to pass through so as to contact the emitter contacts.

As shown in fig. 19, the swivel base 309, on the one hand, provides support for the silicone base 310 thereon in the uninstalled state; on the other hand, when the installation is completed, it can be rotated around the base to the installed state.

Two sides of the rotating seat 309 are provided with 2 extending rods 3091 which have certain elasticity and can retract inwards when being stressed; after the applied force is removed, the extension rod can be restored to the original position.

The end of the rod is provided with 1 cylindrical shaft 3092 which is matched with the semicircular hole of the base.

The cylindrical shaft 3092 has a bevel on its side which contacts and guides the bevel of the base when the rotating base is mounted in the base. Under the action of the extrusion force, the extending rod 3091 is contracted inwards, the cylindrical shaft is clamped into the semicircular hole of the base, and the extending rod can be restored to the original position. The freedom of the rotating seat and the base part is limited, and the rotating seat can only rotate around the cylindrical axis.

The silica gel seat 310 is used for storing conductive rubber 311, providing deformation space for the conductive rubber and limiting the conductive rubber; on the other hand, after the silica gel seat is combined with the plane of the emitter, the waterproof effect can be achieved, and the waterproof grade can reach IPX7.

The silica gel base 310 has a first conductive rubber hole 3101 and a second conductive rubber hole 3102 in the middle. The circular hole is used for placing the conductive rubber 311.

The number of the conductive rubbers 311 is 2, after implantation, the sensor 301 passes through the conductive rubbers, and each conductive rubber is respectively connected with the electrical contacts S+ and S-of the sensor 301 and the emitter 400, so that elastic electrical connection between the sensor and the emitter is realized. The conductive rubber maintains the position of the sensor by friction under pressure except when the circuit is connected.

The silica gel base 310 also has 2 square holes 3103. The square hole aims to reduce the resistance when the guide needle and the puncture needle are removed from the silica gel seat.

The silica gel base 310 has a ring of trapezoidal or triangular ribs 3104 on the top, which can make the emitter more convenient to install and waterproof.

As shown in fig. 20, the electrical system includes an LC filter energy storage module, a wireless SOC module, a functional circuit power module, a sensor excitation and conditioning module, an ADC precision enhancement module, a battery and a sensor, where the positive electrode and the negative electrode of the battery are connected with the LC filter energy storage module through lines respectively, a connection line is provided between the LC filter energy storage module and the VDD end of the wireless SOC module, the connection line is provided with a double-control switch, the double-control switch can be connected with the Da end of the wireless SOC module or the functional circuit power module, the functional circuit power module is connected with the sensor excitation and conditioning module, the Db end of the wireless SOC module is also connected with the sensor excitation and conditioning module, the wireless SOC module has a built-in ADC module, the Dc end of the wireless SOC module and the built-in ADC module are both connected with the ADC precision enhancement module, the ADC precision enhancement module is connected with the sensor excitation and conditioning module, and the positive electrode and the negative electrode of the sensor excitation and the conditioning module are connected with the sensor respectively;

In the SOC module, VDD is the power supply voltage of the SOC, and Da, db, dc are digital output pins of the SOC module. The Da pin is used for controlling the switch S1 to be opened and closed, so that whether the battery supplies power to the functional circuit power supply module or not is controlled. Db is used to select the level of the sensor excitation circuitry, which allows the sensor excitation module to provide both high and low excitation voltage signals to the sensor. Dc is used to inject a noise signal into the ADC accuracy enhancement module. Ain1 and Ain2 are ADC inputs for sampling the conditioned and noise injected sensor voltage output by the ADC precision enhancement module.

The high-precision signal sampling method of the ADC precision enhancement module is characterized by comprising the following steps: injecting a noise voltage with the amplitude of 0 into the sampling signal, and carrying out ADC (analog-to-digital converter) sampling to obtain a Read1 result; step two: injecting an amplitude value into the sampling signal as followsNoise voltage ofTaking the ADC reference voltage, d is the target precision bit number), and carrying out ADC sampling, wherein the result is Read2; step three: the final result read= (read1+read2)/2, and the resulting precision can be enhanced by 1 bit.

In use, after the transmitter 400 is mounted on the base 302, the battery on the base supplies power to the transmitter through the battery lead 4011 connected to V+V-. The rubber lead 4012, conductive rubber 311, and sensor 301, which are connected to the emitter S+S-, form an electrical circuit. When glucose oxidase on the sensor reacts with glucose inside the receptor, a weak current is generated. The transmitter can measure the current value through the electric loop. And converts the measured current value into a blood glucose value of the subject by an algorithm internal to the transmitter. The blood glucose values are then transmitted to the corresponding display device via the wireless transmission module.

While the foregoing is directed to embodiments of the present invention, other and further details of the invention may be had by the present invention, it should be understood that the foregoing description is merely illustrative of the present invention and that no limitations are intended to the scope of the invention, except insofar as modifications, equivalents, improvements or modifications are within the spirit and principles of the invention.

Claims

1. A system for measuring a physiological parameter of a subject, comprising: comprises an implanter (200), a sensor base unit (300) and a transmitter (400), wherein both the implanter (200) and the transmitter (400) are mountable to the sensor base unit (300);

the implanter (200) comprises an implanter upper cover (201), an implanter lower cover (202), a button (203), a bracket (204), a thimble seat (205), a puncture needle seat (206), a guide needle seat (207), a needle return spring (208), a driving spring (209), a thimble (211), a puncture needle (212), a guide needle (213) and a guide limiting block (214), wherein the implanter upper cover (201) and the implanter lower cover (202) form an outer shell, the button (203) is positioned on the implanter upper cover (201), the bracket (204), the thimble seat (205), the puncture needle seat (206) and the guide needle seat (207) are all matched and installed in the outer shell, and the front end of the outer shell is connected with the sensor base device (300);

The support (204) is fixed in the outer shell, the support (204) is of a cylindrical structure with one end open, the opening of the support faces the sensor base device (300), the upper part of the support (204) is a long cylinder (2042), the front end of the support (204) faces the sensor base device (300), the front end of the support (204) is provided with a support elastic clamping rib (2044) which is buckled inwards, the support elastic clamping rib (2044) is used for limiting the guide needle seat (207), the upper part of the rear end is provided with a support buckle (2043) which is used for clamping the ejector needle seat (205), and the outer side of the support (204) is provided with a support boss (2045) which can be buckled with the guide limiting block (214) and a limiting elastic buckle (2046) which limits the movement of the ejector needle seat 205;

the device is characterized in that the ejector pin seat (205) is of a cylindrical structure with two open ends, the ejector pin seat (205) moves in the support (204), the upper part of the ejector pin seat (205) is provided with a sleeve (2052), the long cylinder (2042) penetrates through the sleeve (2052), the edge of the front end of the sleeve (2052) facing the sensor base device (300) is provided with a ring edge, the sleeve (2052) is internally provided with a driving spring (209) for pushing the ejector pin seat (205), the sleeve (2052) is also provided with an elastic card (2051) which is buckled with the support buckle (2043), the button (203) can stir the elastic card (2051), two sides of the ejector pin seat (205) are provided with rectangular holes (2053), the front end of the ejector pin seat (205) is a bevel end (2054), the rear end of the ejector pin seat (205) is provided with an ejector pin boss (2055), the ejector pin (211) is positioned in the ejector pin boss (2055), and the top position of the ejector pin seat (205) is provided with a rib (2058) along the length direction;

The two sides of the puncture needle seat (206) are provided with inclined-plane brackets (2062), the end parts of the inclined-plane brackets (2062) are provided with elastic bolts (2061) which can be clamped into rectangular holes (2053), the upper part of the puncture needle seat (206) is provided with sliding grooves (2063), the sliding grooves (2063) are buckled into ribs (2058) of the top needle seat (205), the puncture needle seat (206) slides in the top needle seat (205) along the ribs (2058), and the puncture needle (212) is positioned in the puncture needle seat (206);

the guide needle seat (207) is of a cylindrical structure with two open ends, a clamping hook (2142) which is buckled with the support boss (2045) is arranged at the side part of the guide limiting block (214), a guide cylinder (2141) is arranged in the middle of the guide limiting block (214), the guide cylinder (2141) penetrates through the guide needle seat (207), one end of the guide needle seat (207) facing the sensor base device (300) is provided with a limiting boss (2071) which is buckled with the support elastic clamping rib (2044), the edge of one end of the guide needle seat (207) which is away from the sensor base device (300) is provided with a circular edge, the guide needle seat (207) is internally provided with a needle returning spring (208) which pushes the guide needle seat (207) to be away from the sensor base device (300) in a movable mode, the guide needle seat (207) is preset in the top needle seat (205) and can pass through the top needle seat (205) to move, the upper part of the guide needle seat (207) is provided with a release boss (2072), the guide needle seat (207) is extruded by the release boss (2072) to press the inclined support (2062), the elastic plug pin (2061) is separated from the hole (2053), the side part of the guide needle seat (207) is also provided with a guide needle returning spring (208) which pushes the guide needle seat (207) away from the sensor base device (300) to move, the guide needle seat (2075), the guide needle (213) is positioned in the guide needle boss (2075);

The sensor base device (300) comprises a base (302) and a rubberized fabric (303), wherein the base (302) is positioned on the rubberized fabric (303); the upper portion of the base (302) is provided with an opening, a battery groove (3021) and a groove (3024) are formed in the base (302), a battery (304) and a battery cover (307) are arranged in the battery groove (3021), a rotating seat (309) is arranged in the groove (3024), the rotating seat (309) is hinged in the groove (3024) by one side of the battery groove (3021), a silica gel seat (310) is arranged in the rotating seat (309), a pair of conductive rubbers (311) are arranged in the silica gel seat (310), a sensor (301) is arranged through the silica gel seat (310) and the rotating seat (309), the sensor (301) can penetrate through the two conductive rubbers (311), an opening (3025) is formed in one side, close to the battery groove (3021), of the groove (3024), and a hole is formed in the adhesive tape (303), and the sensor (301) can penetrate through the opening (3025) and the hole of the adhesive tape (303);

the transmitter (400) comprises a plastic package shell (402) and a circuit board assembly (401), wherein the plastic package shell (402) is covered on the base (302), the circuit board assembly (401) is arranged inside the plastic package shell (402), and the circuit board assembly (401) is provided with four conductive pins which can contact the anode and the cathode of the battery (304) and two conductive rubbers (311);

A button hole (2013) is formed in the upper cover (201) of the implanter, and the button (203) is positioned in the button hole (2013); the button hole (2013) is internally provided with an annular structure, two L-shaped notches (2014) are formed in the annular structure, and one end of each L-shaped notch (2014) faces into the upper cover (201) of the implanter; the bottom surface of the button (203) is provided with a pair of button bosses (2031), the button bosses (2031) can be screwed out of the notch (2014) through rotation of the button (203), the bottom surface of the button (203) is also provided with a trigger rib (2032) capable of poking the elastic card (2051), one trigger rib (2032) corresponds to one elastic card (2051), and when the button bosses (2031) are in a state of being screwed out of the notch (2014), the trigger rib (2032) is positioned right above the elastic card (2051);

the silica gel seat (310) is provided with a first conductive rubber hole (3101) and a second conductive rubber hole (3102), and two conductive rubbers (311) are respectively arranged in the first conductive rubber hole (3101) and the second conductive rubber hole (3102); two square holes (3103) are further formed in the silica gel base (310), the two conductive rubbers (311) and the two square holes (3103) are distributed in a straight line, and the sensor (301) penetrates through the two conductive rubbers (311).

2. A system for measuring a physiological parameter of a subject as defined in claim 1 wherein: deep groove (2026) has been seted up to implant lower cover (202) rear end, is equipped with button frame (215) in deep groove (2026), is equipped with button frame cylinder (2151) on button frame (215), button (203) bottom is equipped with cylinder hole (2033), in cylinder hole (2033) was arranged in to button frame cylinder (2151), around button frame cylinder (2151) in cylinder hole (2033) being equipped with button spring (210).

3. A system for measuring a physiological parameter of a subject as defined in claim 1 wherein: two sides in the groove (3024) are respectively provided with a semicircular hole (3026), two sides of the end part of the rotating seat (309) are respectively provided with a flexible extending rod (3091), the outer side of the extending rod (3091) is provided with a cylindrical shaft (3092), and the cylindrical shaft (3092) is arranged in the semicircular holes (3026) to rotate.

4. A system for measuring a physiological parameter of a subject as defined in claim 1 wherein: an electrode adapter (305) is respectively arranged on the positive electrode and the negative electrode of the battery (304), an electrode connector (306) is arranged on each electrode adapter (305), two round holes (3073) are formed in the battery cover (307), one round hole (3073) corresponds to one electrode connector (306), and the electrode connector (306) penetrates through the round hole (3073) to be partially arranged outside the battery cover (307).

5. The receptor physiological parameter measurement system of claim 4, wherein: four conductive pins on the circuit board assembly (401) are two battery conductive pins (4011) and two rubber conductive pins (4012), the two battery conductive pins (4011) are respectively connected with an electrode connecting piece (306), and the two rubber conductive pins (4012) are respectively connected with one conductive rubber (311).

6. A system for measuring a physiological parameter of a subject as defined in claim 1 wherein: the end part of the base (302) is provided with a base clamping opening (3023), and the end part of the plastic package shell (402) is provided with an edge boss (4021) inserted into the base clamping opening (3023); the side part of the plastic package shell (402) is provided with a shell clamping groove (4022), and the inner side wall of the groove (3024) is provided with an elastic buckle (3027) clamped in the shell clamping groove (4022).

7. A system for measuring a physiological parameter of a subject as defined in claim 1 wherein: the edge of the battery groove (3021) is provided with a sealing strip (308), and the edge of the silica gel seat (310) is provided with a rib position (3104).