CN112450918A

CN112450918A - Novel implantation device of implantable biosensor

Info

Publication number: CN112450918A
Application number: CN202011361444.XA
Authority: CN
Inventors: 杨凯洪; 费英杰
Original assignee: Zhejiang Poctech Corp
Current assignee: Zhejiang Poctech Corp
Priority date: 2020-11-27
Filing date: 2020-11-27
Publication date: 2021-03-09
Anticipated expiration: 2040-11-27
Also published as: CN112450918B

Abstract

The invention relates to a novel implanting device of an implantable biosensor, which comprises an implantable biosensor implanter, wherein an implantable sensor fixing device for placing the implantable biosensor without bending is obliquely clamped at the transmitting end of the implantable biosensor implanter, the implantable sensor fixing device is placed on a base, and the base is detachably and fixedly connected with the implantable biosensor implanter. Push away the implantation biosensor fixing device to the fixed slot of base through implantation biosensor implanter to alright detect in implanting the skin with the detection portion that will not need to buckle the sensor, realized implantation sensor and need not to buckle the sensor after implanting the skin, prevent to receive the influence owing to buckle the sensitivity that leads to the sensor, make the more accurate of effect that detects.

Description

Novel implantation device of implantable biosensor

Technical Field

The invention relates to the field of implantable biosensors, in particular to an implanting device of a novel implantable biosensor.

Background

Monitoring of blood glucose is very important for diabetics, and blood glucose values help to assess conditions of glucose metabolism disorders in diabetics. Currently, the detection of blood glucose can be divided into in vitro detection after blood collection and real-time detection of an implantable blood glucose sensor. When blood sugar is controlled by the method of in vitro detection after blood collection, blood collection is required to be performed for many times every day, which causes heavy burden on the spirit and the flesh of a patient, so that the method of real-time detection by an implantable blood sugar sensor is increasingly popular.

At present, the biosensor can be used for clinical blood sugar continuous monitoring products, and only a micro sensor implanted in subcutaneous tissues is technically verified to a certain degree, so that a tiny and soft biosensor flexible detection part is required to be implanted subcutaneously in the field, a puncture tube penetrates into the subcutaneous tissue at a very high speed, pain feeling is reduced to be extremely low, an electrode part of the sensor is left in the subcutaneous tissue, continuous monitoring is realized, and the part on the skin of the sensor is required to be fixed with the skin. For example, patent document No. CN201610985667.0 discloses a biosensor electrode elastic force type implantation device and a use method thereof, which adopts a puncture combination sleeve, an elastic force type mechanism and a specific stress structure to realize automatic puncture, after the puncture needle exits from the silica gel seat, the silica gel seat rotates along with the rotating seat to be attached to the bottom surface of the sensor base in parallel, so that the sensor is embedded therein; also, as disclosed in patent document CN201310724053.3, the sensor device for subcutaneous tissue with controllable implantation angle is provided, in which the electrodes are implanted into the human body by the cooperation of the implantation device and the sensor assembly, and the sensor mounting seat is pushed into the guide seat, after the half-wall needle is withdrawn, the guide seat is rotated to be clamped with the implanting seat, so that the sensor mounting seat is embedded in the half-wall needle, the fixing mode has the problems that the part on the skin of the sensor needs to be manually pressed flat, this causes the sensor electrode portion to bend, while the electrode portion is laminated by the plurality of electrodes and the insulating layer, due to different material characteristics, the original bonding structure can be damaged and separated when the device is bent, so that the monitoring precision is influenced, meanwhile, although the above patent document does not describe the waterproofing of the electrode contact in detail, the electrode contact is short-circuited when it is in contact with a liquid, and thus it is necessary to pay attention to waterproofing after wearing.

The invention content is as follows:

the implanting device comprises an implanting biosensor implanter, wherein an implanting sensor fixing device for placing an implanting biosensor without bending is obliquely clamped at the emitting end of the implanting biosensor implanter, the implanting sensor fixing device is placed on a base, the base is detachably and fixedly connected with the implanting biosensor implanter, when in use, the implanting biosensor without bending is only required to be placed into the implanting biosensor fixing device, the implanting biosensor fixing device is arranged at the emitting end of the implanting biosensor implanter, the base is detachably connected with the implanting biosensor implanter, then the base is attached to the surface of the skin, the implanting biosensor fixing device is pushed into a fixing clamping groove of the base by the implanting biosensor implanter, therefore, the detection part of the sensor which is not required to be bent can be implanted into the skin for detection, the implanted sensor is implanted into the skin without being bent, the sensitivity of the sensor is prevented from being influenced due to bending, meanwhile, the transmitting end of the implanted biosensor implanting device is obliquely arranged with the fixing device, the flexible detection part of the implanted biosensor can be obliquely implanted into the skin, the oblique implantation can be guaranteed to be implanted into the skin at the same depth, the blood which is implanted into the skin by the reinforced flexible detection part can be deeper, and the detection effect is more accurate.

The utility model provides a novel implantation of implantation nature biosensor device, is including implantation nature biosensor implantation ware, the transmission end slope joint of implantation nature biosensor implantation ware has the implantation nature sensor fixing device who places the implantation nature biosensor that need not buckle, implantation nature sensor fixing device place with the base on, the base with implantation nature biosensor implantation ware can dismantle fixed connection.

Preferably, the base rotates to be connected with the lid of mutually supporting, the shaping has on the base and implants ware complex installation department with implantation nature biosensor, seted up on the lid with installation department complex installation cavity, the edge of installation department offers the fixed slot who is used for spacing implantation nature sensor fixing device, the fixed slot has seted up the breach on being close to one side cell wall of implantation nature biosensor electrical contact, be fixed with the sealing washer on the lateral wall of laminating mutually with implantation nature biosensor electrical contact place side on the installation cavity.

Preferably, the implantable sensor fixing device comprises a lower fixing seat and an upper fixing seat which are matched with each other, a fixing groove used for placing the implantable biosensor which does not need to be bent is formed in the lower fixing seat, a clamping groove is formed in the groove wall of the fixing groove along the length direction of the fixing groove, a first buckle matched with the lower fixing seat is formed in the side wall of the upper fixing seat, and an electrode hole is formed from the upper surface to the lower surface of the upper fixing seat.

Preferably, the implantable biosensor comprises a blank electrode layer, a working electrode layer, a reference electrode layer and a counter electrode layer, wherein the blank electrode layer, the working electrode layer, the reference electrode layer and the counter electrode layer all comprise a circuit contact part and a flexible implantation detection part, a transition connection part between the circuit contact part and the flexible implantation detection part is in a bending design, and a bending angle C between the circuit contact part and the flexible implantation detection part is 120-150 degrees.

Preferably, the side of fixing base along width direction one side is the inclined plane of mutually supporting with the flexible detection portion of implantation nature biosensor down, the inclined plane one side shaping of fixing base has first fixture block down, down the fixing base with the opposite side shaping in inclined plane has the second fixture block, first fixture block is kept away from with the second fixture block down the one side of fixing base all with the inclined plane is parallel to each other, one side shaping that the fixing base shaping has the second fixture block down has the third stopper, the third stopper is kept away from the side of fixing base with the inclined plane is parallel to each other.

Preferably, the fixed clamping groove is matched with the overall dimension of the implantable biosensor fixing device, a groove is formed in the groove wall adjacent to the notch of the fixed clamping groove, a clamping block used for limiting the implantable sensor fixing device is formed in the groove wall of the groove, one end of the clamping block is fixed with the groove wall of the groove, and the other end of the clamping block is a free end and extends into the fixed clamping groove in an inclined mode.

Preferably, a through hole for passing through the half-wall needle is formed in one end, far away from the clamping block, of the bottom of the fixing clamping groove, an upper arc-shaped groove and a lower arc-shaped groove are formed in the lower fixing seat and the upper fixing seat respectively, and the upper arc-shaped groove and the lower arc-shaped groove form a through hole for passing through the half-wall needle.

Preferably, the base is formed with a limiting rotation shaft hole, a first limiting block is formed in the limiting rotation shaft hole, the cover body is formed with a limiting rotation shaft matched with the limiting rotation shaft, the limiting rotation shaft is far away from one end of the cover body is formed with a second limiting block matched with the first limiting block, the first limiting block is far away from the end face of the cover body and the top face of the limiting rotation shaft hole, and the distance between the end face of the cover body and the cover body is equal to the distance between the end face of the second limiting block and the cover body.

Preferably, keep away from on the installation department fixed slot's side shaping has the locking elastic block, the locking elastic block is kept away from the one end of installation department extends to be close to the edge of base, on the lateral wall of installation cavity at its relevant position shaping have with it complex buckle seat.

Preferably, a bump is formed at the edge of the base far away from the limiting rotation shaft hole, a clamping groove is formed in the side face of the bump, and a clamping block matched with the cover body is formed at the corresponding position of the cover body.

The invention has the beneficial effects that:

(1) the implanting device comprises an implanting biosensor implanter, wherein an implanting sensor fixing device for placing an implanting biosensor without bending is obliquely clamped at the emitting end of the implanting biosensor implanter, the implanting sensor fixing device is placed on a base, the base is detachably and fixedly connected with the implanting biosensor implanter, when in use, the implanting biosensor without bending is only required to be placed into the implanting biosensor fixing device, the implanting biosensor fixing device is arranged at the emitting end of the implanting biosensor implanter, the base is detachably connected with the implanting biosensor implanter, then the base is attached to the surface of the skin, the implanting biosensor fixing device is pushed into a fixing clamping groove of the base by the implanting biosensor implanter, therefore, the detection part of the sensor which is not required to be bent can be implanted into the skin for detection, the implanted sensor is implanted into the skin without being bent, the sensitivity of the sensor is prevented from being influenced due to bending, meanwhile, the transmitting end of the implanted biosensor implanting device is obliquely arranged with the fixing device, the flexible detection part of the implanted biosensor can be obliquely implanted into the skin, the oblique implantation can be guaranteed to be implanted into the skin at the same depth, the blood which is implanted into the skin by the reinforced flexible detection part can be deeper, and the detection effect is more accurate.

(2) The invention relates to a base and a cover body which is rotationally connected with the base and mutually matched with the base, wherein a mounting part matched with an implantable biosensor implanter is formed on the base, a mounting cavity matched with the mounting part is arranged on the cover body, a fixing clamping groove for limiting an implantable biosensor transmission fixing device is arranged at the edge of the mounting part, a notch is arranged on one side groove wall of the fixing clamping groove close to a sensor electric contact, a sealing ring is fixed on the side wall of the mounting cavity, which is attached to the side surface where the sensor electric contact is arranged, when the implantable biosensor fixing device carries the implantable biosensor without bending to enter the fixing clamping groove, the electric contact of an electrode column on the implantable biosensor faces to one side of the notch and is exposed, a limiting rotating shaft arranged on the cover body is inserted into a limiting rotating shaft hole arranged on the base through a certain angle, then rotatory lid makes the buckle seat on the lid and the locking elastic block joint on the installation department, thereby the sealing washer follows the lid simultaneously and rotates and closely laminate with sensor fixing device's side, seals the electric contact of electrode post, and isolated external liquid medium contacts the electric contact of electrode post, reaches sealed effect, does not worry after wearing that bathing, swimming are to the influence of monitoring precision.

(3) The fixing device comprises a lower fixing seat and an upper fixing seat which are mutually matched, wherein a fixing groove for placing the implantable sensor without bending is arranged in the lower fixing seat, a through groove is arranged on the side wall of the lower fixing seat along the length direction of the fixing groove, a first buckle which is mutually matched with the lower fixing seat is arranged on the side wall of the upper fixing seat, and an electrode hole is arranged from the upper surface to the lower surface of the upper fixing seat, the sealing washer on the skin fixing base lid can cover the contact of electrode post completely, prevents to go up the upper surface of fixing base because the surface height difference leads to water infiltration and contacts the electrode post.

(4) The implantable biosensor is of a layered structure and comprises a blank electrode layer, a working electrode layer, a reference electrode layer and a counter electrode layer, wherein the blank electrode layer, the working electrode layer, the reference electrode layer and the counter electrode layer respectively comprise a circuit contact part and a flexible implantation detection part, and a transition connection part between the circuit contact part and the flexible implantation detection part is in a bending design.

Description of the drawings:

FIG. 1 is a schematic diagram of an implanter apparatus of the present invention in a split configuration;

FIG. 2 is an overall schematic of the present invention;

fig. 3 is an inside elevational view of the implanter of the present invention with half the housing removed;

FIG. 4 is a rear interior view of the implanter of the present invention with half of the housing removed;

FIG. 5 is a half-sectional view of an implanter housing of the present invention;

FIG. 6 is a three-dimensional view of the slide chair of the present invention;

FIG. 7 is a front view of the slide block of the present invention;

FIG. 8 is a rear elevational view of the slide base of the present invention;

FIG. 9 is a rear half sectional view of the slide clamp sensor assembly of the present invention;

FIG. 10 is an enlarged, fragmentary view of FIG. 9A of the present invention;

FIG. 11 is a front view of a sensor assembly of the present invention;

FIG. 12 is a rear elevational view of the sensor assembly of the present invention;

FIG. 13 is a view of the separation seat of the present invention in combination with a half-wall needle;

FIG. 14 is a back schematic view of an implantable biosensor of the present invention;

FIG. 15 is a schematic structural view of the present invention;

FIG. 16 is an exploded view of FIG. 15;

FIG. 17 is a schematic structural view of a base according to the present invention;

FIG. 18 is a schematic structural view of a base according to the present invention;

FIG. 19 is a top view of the base of the present invention;

FIG. 20 is a cross-sectional view taken along line FF of FIG. 19;

FIG. 21 is a schematic structural view of the upper cover;

FIG. 22 is a schematic view of an implantable biosensor mounting device according to the present invention in a split configuration;

FIG. 23 is a schematic view of a lower mounting bracket of the present invention;

FIG. 24 is a side view of the upper mounting base of the present invention;

FIG. 25 is a schematic view of an implantable biosensor according to the present invention

FIG. 26 is a schematic exploded view of an implantable biosensor according to the present invention;

FIG. 27 is a schematic view of an implantable biosensor mounting device of the present invention passing through a hole;

in the drawings: 1. implanting into the mouth; 2. an implanter housing; 3. a sliding seat; 5. a semi-through slot; 6. a guide groove; 7. a separation plate; 8. a sensor fixture block; 9. a separating seat clamping block; 10. clamping a plate; 11. an installation port; 12. an implanter cover; 13. an elastic clip; 14. reinforcing ribs; 15. a sliding groove; 16. clamping the strip; 17. a clamping hole; 18. a hook-shaped chuck; 19. a button fixture block; 20. a propulsion spring; 21. an annular groove; 22. separating the seat hook; 23. a barb; 24. a separation spring; 25. a sensor assembly; 26. a separating seat; 27. a semi-wall needle; 30. a sensor fixture recess; 31. a separation seat groove; 32. a separation tank; 34. a button; 36. a limiting strip; 100. a base; 110. an installation part; 120. fixing the clamping groove; 121. a notch; 122. a groove; 123. a clamping block; 124. a through hole; 125. an empty groove; 130. limiting a rotating shaft hole; 131. a first stopper; 132. a guide block; 140. locking the elastic block; 141. briquetting; 150. a bump; 151. a card slot; 160. positioning blocks; 170. a clamping groove; 200. a cover body; 210. a mounting cavity; 211. a seal ring; 212. a buckle seat; 220. limiting the rotating shaft; 221. a second limiting block; 230. a clamping block; 40. a lower fixed seat; 401. fixing grooves; 402. a card slot; 403. an inclined surface; 404. a first clamping block; 405. a second fixture block; 406. a third limiting block; 407. a lower arc groove; 41. an upper fixed seat; 411. a first buckle; 412. an electrode hole; 413. an upper arc-shaped groove; 414. an electrode column; 50. an implantable biosensor; 501. a blank electrode layer; 502. a working electrode layer; 503 a reference electrode layer; 504 a pair of electrode layers; 505. a circuit contact portion; 506. a flexible implantation detection section; 43. an implantable biosensor fixture; 70. an implantable biosensor implanter;

the specific implementation mode is as follows:

the technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

In the description of the present invention, it is to be understood that the terms "central," "longitudinal," "lateral," "length," "width," "thickness," "upper," "lower," "front," "rear," "left," "right," "vertical," "horizontal," "top," "bottom," "inner," "outer," "clockwise," "counterclockwise," "axial," "radial," "circumferential," and the like are used in the orientations and positional relationships indicated in the drawings for convenience in describing the invention and to simplify the description, and are not intended to indicate or imply that the referenced devices or elements must have a particular orientation, be constructed and operated in a particular orientation, and are therefore not to be considered limiting of the invention.

In the present invention, unless otherwise expressly specified or limited, the terms "disposed," "mounted," "connected," and "fixed" are to be construed broadly and may, for example, be fixedly connected or detachably connected; may be a mechanical connection; may be directly connected or indirectly connected through an intermediate. The specific meanings of the above terms in the present invention can be understood by those skilled in the art according to specific situations.

Furthermore, the terms "first", "second", etc. are used for descriptive purposes only and are not to be construed as indicating or implying relative importance or implicitly indicating the number of technical features indicated. Thus, a feature defined as "first" or "second" may explicitly or implicitly include one or more of that feature.

According to the present invention, as shown in fig. 1-27, there is provided a technical solution:

a novel implantation device of an implantable biosensor comprises an implantable biosensor implanter 70, wherein an implantable sensor fixing device 43 for placing an implantable biosensor 50 which does not need to be bent is obliquely clamped at the emitting end of the implantable biosensor implanter 70, the emitting end of the implantable biosensor implanter 70 is an upward inclined surface, the clamping surface of the implantable sensor fixing device 43 and the implantable biosensor implanter 70 is a horizontal surface, the surface of a separating seat 26 contacted with the implantable sensor fixing device 43 and the emitting end of the implantable biosensor implanter 70 are both upward inclined surfaces and are parallel to each other, so that the implantable biosensor implanter 70 can be obliquely implanted when being connected with the implantable sensor fixing device 43, the implantable sensor fixing device 43 is placed on a base 100, the base 100 is detachably and fixedly connected to the implantable biosensor implanter 70.

Specifically, the base is rotatably connected with a cover body 200 which is matched with each other, the base 100 and the cover body 200 can be made of plastic, the lower surface of the base 100 is provided with a rubberized fabric which is used for being fixed with skin, a battery which provides a power supply for the sensor and a wireless data transmission part which is used for transmitting monitoring data are arranged in the cover body 200, the base 100 is formed with an installation part 110 which is matched with the implantable biosensor implanter 70, the cover body 200 is provided with an installation cavity 210 which is matched with the installation part 110, the edge of the installation part 110 is provided with a fixed clamping groove 120 which is used for limiting the implantable sensor fixing device 43, one side wall of the fixed clamping groove 120 which is close to the electric contact of the implantable biosensor 50 is provided with a notch 121, a sealing ring 211 is fixed on the side wall which is attached to the side where the electric contact of the implantable biosensor 50 is located on the installation cavity 210, and, after the sensor fixing device is installed, the sealing ring 121 is tightly attached to the side where the electrical contact is located, so that a waterproof effect is achieved.

Specifically, the implantable sensor fixing device 43 includes a lower fixing base 40 and an upper fixing base 41 which are mutually matched, the upper fixing base 41 is made of silica gel, a fixing groove 401 for placing the implantable biosensor 50 which does not need to be bent is formed in the lower fixing base 40, a clamping groove 402 is formed on a groove wall of the fixing groove 401 along the length direction, a first buckle 411 which is mutually matched with the lower fixing base 40 is formed on a side wall of the upper fixing base 41, an electrode hole 412 is formed from the upper surface to the lower surface of the upper fixing base 41, an electrode column 414 is embedded into the electrode hole 212, the upper fixing base 41 is embedded into the lower fixing base 40 through the matching of the buckle and the clamping groove 402, a contact of the electrode column is exposed, and a circuit contact portion 505 of the implantable biosensor 50 which does not need to be bent has a waterproof function through the manner that the lower fixing base 40 is tightly attached to the upper fixing base 41, simultaneously through setting up buckle and draw-in groove 402 at the side, make the upper surface of going up fixing base 41 only expose outside electrode post contact outstanding, be convenient for the later stage implant the base 100 after, sealing washer 211 on the lid 200 of base 100 can cover the contact of electrode post 414 completely, prevent that water from contacting electrode post 414, make fixing device wholly possess waterproof function, the upper surface that prevents to go up the fixing base is because the surface height is different, lead to water infiltration and contact the electrode post, make fixing device and skin fixing base 60 cooperate the use after, the circuit contact part that can make implantation nature biosensor possesses waterproof effect, make implantation nature biosensor also can the operation in the environment that has liquid.

Specifically, the cross section of the first buckle 411 is trapezoidal, the inclined plane inclination angle a of the side of the first buckle 411 close to the bottom surface of the fixing groove 401 is 20-30 °, and when the upper fixing base is implanted into the lower fixing base 40, the first buckle 411 can be conveniently clamped into the clamping groove 402 of the lower fixing group 40 due to the large inclination angle, so that the assembly is facilitated.

Specifically, the implantable biosensor 50 is a layered structure, and includes a blank electrode layer 501, a working electrode layer 502, a reference electrode layer 503 and a counter electrode layer 504, the blank electrode layer 501, the working electrode layer 502, the reference electrode layer 503 and the counter electrode layer 504 each include a circuit contact portion 505 and a flexible implantation detection portion 506, and a transition connection portion between the circuit contact portion 505 and the flexible implantation detection portion 506 is in a bending design.

Specifically, the bending angle C between the circuit contact part 505 and the flexible detection part 506 is 120-150 °, the bending design between the implanted biological circuit contact part 505 and the flexible detection part 506 is ensured, and meanwhile, when the circuit contact part 505 and the skin are parallel to each other, the flexible detection part 506 is obliquely implanted into the skin, the oblique implantation can ensure that the blood implanted into the skin by the reinforced flexible detection part 506 is deeper under the same implantation depth, so that the detection effect is more accurate.

Specifically, the transitional connection part between the circuit contact 505 and the flexible detection part 506 is in a circular arc shape, so that the connection strength is ensured;

specifically, the thickness of the blank electrode layer 501, the working electrode layer 502, the reference electrode layer 503 and the counter electrode layer 504 after being laminated is 0.25-0.3 mm, so that the blank electrode layer can be maximally thin, the light volume is ensured, and the use is convenient.

Specifically, the width C of the end part, far away from the circuit contact part 505, of the flexible detection part 506 is 0.07-0.14 mm, so that the wound area of skin is reduced, foreign body sensation is reduced, and the use comfort level is increased.

Specifically, the structural strength of the flexible implantation detection part 506 gradually decreases from the root connected to the circuit contact part 505 to the end far away from the circuit contact part 505, and the gradual decrease of the structural strength may be linear or stepped, so that the thickness of the flexible implantation detection part changes and becomes thinner when the flexible implantation detection part is far away from the root, and the stimulation to the tissue is further reduced, and similarly, the flexibility is increased when the thickness of the flexible implantation detection part is near the root, and the flexible implantation detection part can be prevented from breaking; because the stress of the sensor is larger and larger along with the gradual approach to the root, if the thickness of the sensor is made to be consistent, the sensor is easy to break or crack in order to avoid stimulating the subcutaneous tissue to be thinner, especially, the sensor is more stressed and more concentrated in stress and is also easier to break and crack in the place close to the root, and the measurement precision of the sensor can be influenced.

Specifically, the circuit contact portions 505 of the blank electrode layer 501, the working electrode layer 502, the reference electrode layer 503 and the counter electrode layer 504 are all rectangular parallelepipeds and have the same width, so that the overall aesthetic property is ensured, and the processing technology is simple.

Specifically, the side surface of the lower fixing base 40 along one side of the width direction is an inclined surface 403 which is matched with the flexible detection portion 506 of the implantable biosensor 50, a first latch 404 is formed on one side of an inclined surface 413 of the lower fixing base 40, a second latch 405 is formed on the side surface of the lower fixing base 40 opposite to the inclined surface 403, the surfaces of the first latch 404 and the second latch 405 far away from the lower fixing base 40 are both parallel to the inclined surface 403, a third stop block 406 is formed on the side of the lower fixing base 40 where the second latch 405 is formed, the side surface of the third stop block 406 far away from the fixing base 40 is parallel to the inclined surface 403, the size and shape of the fixing slot 120 are matched with the shape and the shape of the external dimension of the implantable biosensor fixing device 43, when the implantable biosensor fixing device 43 receives the inclined launching force of the implanter 70, the implantable biosensor fixing device is implanted into the fixing slot 120 along the inclined directions of the first stopper 404, the second stopper 405 and the third stopper 406, and the inclined surfaces of the first stopper 404, the second stopper 405 and the third stopper 406 play a role in inclined guiding.

A groove 122 is formed in a groove wall of the fixing groove 120 adjacent to the notch 121, a clamping block 123 for limiting the position of the implantable sensor fixing device 43 is formed on the groove wall of the groove 122, one end of the clamping block 123 is fixed to the groove wall of the groove 122, and the other end of the clamping block 123 is a free end and extends into the fixing groove 120 in an inclined manner.

Specifically, a through hole 124 for passing through the half-wall needle 27 is formed in one end of the groove bottom of the fixing clamping groove 120, which is far away from the clamping block 123, the lower fixing seat 40 and the upper fixing seat 41 are respectively provided with an upper arc-shaped groove 413 and a lower arc-shaped groove 407 which are matched with the flexible implantation detection part of the implantable biosensor, and the upper arc-shaped groove 413 and the lower arc-shaped groove 406 form a through hole 414 for passing through the half-wall needle 27.

Specifically, the base 100 is provided with a limiting rotation shaft hole 130, the cover 200 is formed with a limiting rotation shaft 220 engaged therewith, in order to facilitate insertion of the limiting rotation shaft 220, the limiting rotation shaft hole 130 can be vertically divided into a guide portion and a limiting portion, the aperture of the guide portion of the limiting rotation shaft hole 130 is gradually increased from bottom to top, a sector-ring-shaped guide block 132 is further formed in the guide portion, the radian of the guide block 132 is gradually decreased from bottom to top, during assembly, the guide portion can facilitate the limiting rotation shaft 220 to enter along the guide block 132, a first limiting block 131 is formed in the limiting portion of the limiting rotation shaft hole 130, the first limiting block 131 is fixedly connected with the guide block 132 and has the same radian as the radian of the lower end face of the guide block 132, and a second limiting block 221 engaged with the first limiting block 131 is formed at one end of the limiting rotation shaft 220 away from the cover 200, the distance between the end face of the first limiting block 131 far away from the cover body 200 and the top face of the limiting rotation shaft hole 130 is equal to the distance between the end face of the second limiting block 221 near the cover body 200 and the cover body 200, the diameter of the aperture surrounded by the two first limiting blocks 131 is equal to the diameter of the limiting rotation shaft 220, the limiting rotation shaft 220 is inserted into the limiting rotation shaft hole 130 formed in the base 100 through a certain angle, the limiting rotation shaft 220 can conveniently enter a limiting part through a guide part, and then the cover body 200 is rotated to enable the buckle seat 212 to be clamped with the locking elastic block 140 on the mounting part.

Specifically, the number of the first limiting blocks 131 may be one or more, in this embodiment, the number of the first limiting blocks 131 is two, and the axial lines of the limiting rotation shaft holes 130 are distributed in a central symmetry manner, so that the assembly firmness is ensured and the complexity of the mold is reduced.

Specifically, a locking elastic block 140 is formed on the side surface of the mounting portion 110 far away from the fixing slot 120, one end of the locking elastic block 140 far away from the mounting portion 110 extends to be close to the edge of the base 100, a buckle seat 212 matched with the locking elastic block is formed on the side wall of the mounting cavity 210 at the corresponding position, and since the sensor electrode cannot be retained in a human body for a long time and needs to be taken out after a period of time, a pressing block 141 convenient for fingers to press is formed on the side surface of the end portion of the locking elastic block 140 far away from the mounting portion 110, so that the connection between the base 100 and the cover body 200 is convenient to loosen, due to the existence of the pressing block 141 and the locking elastic block 140, a drainage hole communicated with the inside is formed on the side wall of the mounting portion 110 near the pressing block 141, and water in.

Specifically, a protrusion 150 is formed at an edge of the base 100 away from the limiting rotation shaft hole 130, a slot 151 is formed at a side surface of the protrusion 150, and a latch 230 is formed at a corresponding position of the cover 200 and is engaged with the protrusion. When the base 100 and the cover 200 are rotationally fixed, the latch 230 is inserted into the slot 151 like a latch for enhancing the fixation of the cover 200 and the base 100, and on the other hand, the protrusion 150 can limit the cover 200 from over-rotation.

Specifically, the installation portion 110 is formed with a positioning block 160 matched with the implantable biosensor implanter 70 on the side opposite to the notch 121, and the installation portion 110 is provided with two opposite side walls adjacent to the notch 121, which are provided with clamping grooves 170 matched with each other, so as to realize detachable connection.

Specifically, the fixing slot 120 is provided with a hollow groove 125 on a groove wall opposite to the notch 121 for accommodating the implanter sliding seat 3.

Specifically, the implantable biosensor implanter 70 comprises an implanter shell 2 with an implantation port 1, a sliding seat 3 is installed in the implanter shell 2, a sensor assembly 25 is fixedly installed below the sliding seat 3, an implanter cover body 12 is covered on the side portion of the implanter shell 2, one end of the sliding seat 3 is provided with a cavity, two opposite sides of the cavity along the length direction of the sliding seat 3 are provided with semi-through grooves 5, two opposite guide grooves 6 are arranged on two sides of the cavity adjacent to the semi-through grooves 5, a separation plate 7 is fixedly connected with the groove bottom of one of the semi-through grooves 5, a gap is reserved between the side wall of the separation plate 7 and the side wall of the semi-through groove 5, the inner wall of the separation plate 7 is provided with a sensor fixture block 8 and a separation seat fixture block 9, the outer wall of the separation plate 7 is fixedly provided with a clamping plate 10, and the position of the sliding seat for fixing the separation seat is moved to the back of the separation seat by reducing one, compared with the prior implanter in which the clamping plates are arranged on the two sides of the separating seat, the invention can prevent the clamping plates on the two sides from forming an included angle to influence the separation of the separating seat, and meanwhile, the prior implanter separating seat is clamped on the two sides.

Specifically, the injector housing 2 has a button 34 formed on an outer surface thereof.

Specifically, one end of the sliding seat 3, which is far away from the cavity, is provided with a button fixture block 19 which is matched with the button 34, and an annular groove 21 for installing the pushing spring 20 is formed below the button fixture block 19.

Specifically, the urging spring 20 is connected to the annular groove 21 at one side and connected to the implanter housing 2 at the other side.

Specifically, the sensor fixture block 8 and the separating seat fixture block 9 are connected with a sensor assembly 25 in a clamped manner, a separating seat hook 22 is formed on the sensor assembly 25, a barb 23 is arranged at one end, far away from the separating seat fixture block 9, of the separating plate 7 in the length direction of the sliding seat 3, and the barb 23 is connected with the separating seat hook 22 through a separating spring 24.

Specifically, the sensor assembly 25 includes a separation seat 26 provided with the separation seat hook 22, a half-wall needle 27 is embedded in the separation seat 26, the half-wall needle 27 is cylindrical and hollow, and a flexible detection portion 506 of the implantable biosensor fixing device 43 is embedded in the hollow portion of the half-wall needle 27.

In particular, the separating seat hook 22 is provided on the separating seat 26.

In particular, the guide groove 6 is used for guiding the disengagement of the separating seat 26.

Specifically, the implantable biosensor fixing device 43 is provided with a sensor fixing device groove 30 for matching with the sensor fixture block 8, the separation seat 26 is provided with a separation seat groove 31 for matching with the separation seat fixture block 9, and the sensor fixing device 28 is formed with a block fitting with the rail shape of the guide groove 6 and provided with the sensor fixing device groove 30.

Specifically, a separation groove 32 matched with the clamping plate 10 is formed in the implanter shell 2, and the separation groove 32 is used for clamping the clamping plate 10 so as to loosen the sensor clamping block 8 and the separation seat clamping block 9.

Specifically, the bottom end of the separation groove 32 is inclined inward, so that the clamping plate 10 can strike the bottom edge of the separation groove 32 during the downward sliding process of the sliding seat 3.

Specifically, a mounting opening 11 is formed in a side wall of the implanter shell 2, and an implanter cover 12 is covered on the mounting opening 11.

Specifically, after the implanter housing 2 and the implanter cover 12 are closed, the push spring 20 is under compression and the release spring 24 is under tension.

Specifically, one side of the implanter shell 2 close to the cavity is provided with an elastic clip 13 matched with the base 35, and the elastic clip 13 and the guide groove 6 are coplanar.

Specifically, a reinforcing rib 14 is fixedly connected between the clamping plate 10 and the separating plate 7, and the reinforcing rib 14 is used for reinforcing the clamping plate 10 and preventing the clamping plate 10 from being damaged by impact.

Specifically, an included angle B between the clamping plate 10 and the separating plate 7 is 30-60 degrees, so that the clamping plate 10 is easier to pull out the separating plate 7 when impacting the separating groove 32.

Specifically, the outer wall of the sliding seat 3 is provided with a sliding groove 15, and the inner wall of the implanter shell 2 is provided with a clamping strip 16 matched with the sliding groove 15.

Specifically, a limiting strip 36 which is in clearance fit with the clamping plate 10 and the guide groove 6 is arranged in the implanter shell 2.

Specifically, hook-shaped chucks 18 are formed on two sides of the implanter cover 12, and a mounting hole 17 matched with the hook-shaped chucks 18 is formed in the mounting hole 11 of the implanter shell 2.

Specifically, the sensor fixture block 8 with the cross-section of separating seat fixture block 9 all is trapezoidal, the trapezoidal inclined plane in separating seat fixture block 9 cross-section is close to one side of barb 23, trapezoidal make its joint face bigger, the joint is more stable.

The working principle is as follows: when in use, the implantable biosensor 50 and the electrode column 414 are placed into the lower fixing seat 40, then the upper fixing seat 41 is embedded into the lower fixing seat 41 through the first buckle 411, so that the electrode contact of the electrode column 414 is exposed in the air through the electrode hole 412, then the implantable biosensor fixing device 43 is clamped with the sensor fixture block 8 of the implantable biosensor implanter 70 through the sensor fixing device groove 30, then the elastic clamp 13 of the implantable biosensor implanter 70 is opened, the clamping groove 170 of the base 100 is matched with the electrode column, so that the holding surface and the clamping surface of the implanter are coplanar, the shaking of the implanter in the inclined direction caused by inclined holding is prevented, the pushing spring 20 of the sliding seat 3 is pre-tightened in the annular groove 21 of the implanter housing 2, and the button fixture block 19 on the sliding seat 3 is released by pressing the button 34 of the implanter housing 2, the preloaded push spring 20 pushes the sliding seat 3 to drive the sensor assembly 25 in the cavity downwards to push towards the base 35, when the clamping plate 10 moves to the separation groove 32 of the implanter shell 2, the clamping plate 10 impacts the edge of the separation groove 32 to cause the deformation and bending of the separation plate 7, so that the sensor fixture blocks 8 and the separation seat fixture blocks 9 are separated from the sensor fixing device 28 and the separation seat 26 respectively, because the separation seat 26 is provided with the separation seat hook 22, the separation seat hook 22 is connected with the barb 23 on the separation plate 7 through the separation spring 24 and is in a tensioning state, the separation seat 26 losing the axial limit at the moment can be separated from the implantable biosensor fixing device 43 along the guide groove 6 under the force of the separation spring 24, at the moment, the implantation of the implantable biosensor is finished, meanwhile, the half-wall needle 27 on the separation seat 26 and the separation seat 26 is recovered, and finally, the implantation can be finished only by opening the elastic clamp 13 to separate from the base 100, then the limit rotation shaft 220 on the cover body 200 is inserted into the limit rotation shaft hole 130 at a certain angle, and then the cover body 200 is rotated to clamp the clamping seat 212 on the cover body 200 with the locking elastic block 140 on the mounting part 110, and simultaneously the sealing ring 211 rotates along with the cover body 200 to tightly attach to the side surface of the fixing device 43 of the implantable biosensor, so that the external liquid medium is isolated from entering, and the sealing effect is achieved.

Although the present invention has been described in detail with reference to the foregoing embodiments, it will be apparent to those skilled in the art that modifications may be made to the embodiments or portions thereof without departing from the spirit and scope of the invention.

Claims

1. The utility model provides a novel implantation of implantation nature biosensor device, its characterized in that, including implantation nature biosensor implanter (70), the transmission end slope joint of implantation nature biosensor implanter (70) has implantation nature sensor fixing device (43) of placing implantation nature biosensor (50) that need not buckle, implantation nature sensor fixing device (43) are placed with on base (100), base (100) with implantation nature biosensor implants (70) can dismantle fixed connection.

2. The implanting device of the implantable biosensor as claimed in claim 1, wherein the base is rotatably connected with a cover (200) that is engaged with each other, an installing part (110) engaged with the implantable biosensor implanter (70) is formed on the base (100), an installing cavity (210) engaged with the installing part (110) is formed on the cover (200), a fixing groove (120) for limiting the implantable sensor fixing device (43) is formed at an edge of the installing part (110), a notch (121) is formed on a side wall of the fixing groove (120) close to the electrical contact of the implantable biosensor (50), and a sealing ring (211) is fixed on a side wall of the installing cavity (210) that is engaged with a side surface of the electrical contact of the implantable biosensor (50).

3. The implanting device of a novel implantable biosensor according to claim 1, wherein the implantable sensor fixing device (43) comprises a lower fixing base (40) and an upper fixing base (41) which are matched with each other, a fixing groove (401) for placing the implantable biosensor (50) which does not need to be bent is formed in the lower fixing base (40), a groove wall of the fixing groove (401) along the length direction is provided with a clamping groove (402), a side wall of the upper fixing base (41) is provided with a first buckle (411) which is matched with the lower fixing base (40), and an electrode hole (412) is formed from the upper surface to the lower surface of the upper fixing base (41).

4. The implanting device of a novel implantable biosensor according to claim 1, wherein the implantable biosensor (50) comprises a blank electrode layer (501), a working electrode layer (502), a reference electrode layer (503) and a counter electrode layer (504), the blank electrode layer (501), the working electrode layer (502), the reference electrode layer (503) and the counter electrode layer (504) each comprise a circuit contact portion (505) and a flexible implantation detecting portion (506), a transition connection portion between the circuit contact portion (505) and the flexible implantation detecting portion (506) is in a bending design, and a bending angle C between the circuit contact portion (505) and the flexible implantation detecting portion (506) is 120-150 °.

5. The implant device of the new implantable biosensor in claim 1, the side surface of one side of the lower fixed seat (40) along the width direction is an inclined surface (403) which is matched with a flexible detection part (506) of the implanted biosensor (50), a first clamping block (404) is formed on one side of the inclined surface (413) of the lower fixing seat (40), a second clamping block (405) is formed on the side surface of the lower fixed seat (40) opposite to the inclined surface (403), one surfaces of the first fixture block (404) and the second fixture block (405) far away from the lower fixing seat (40) are parallel to the inclined surface (403), a third limit block (406) is formed at one side of the lower fixing seat (40) where the second clamping block (405) is formed, the side surface of the third limiting block (406) far away from the fixed seat (40) is parallel to the inclined surface (403).

6. The implanting device of a novel implantable biosensor as claimed in claim 5, wherein the fixing slot (120) is matched with the external dimension of the implantable biosensor fixing device (43), the fixing slot (120) is provided with a groove (122) on the wall of the groove adjacent to the gap (121), a block (123) for limiting the implantable biosensor fixing device (43) is formed on the wall of the groove (122), one end of the block (123) is fixed with the wall of the groove (122), and the other end is a free end and extends obliquely into the fixing slot (120).

7. An implantable sensor skin anchor according to claim 6, wherein: a through hole (124) used for penetrating a half-wall needle (27) is formed in one end, far away from the clamping block (123), of the groove bottom of the fixed clamping groove (120), an upper arc-shaped groove (413) and a lower arc-shaped groove (407) are respectively formed in the lower fixing seat (40) and the upper fixing seat (41), and the upper arc-shaped groove (413) and the lower arc-shaped groove (406) form a penetrating hole (414) used for the half-wall needle (27) to penetrate.

8. An implantable sensor skin anchor according to claim 2, wherein: the base (100) is provided with a limiting rotation shaft hole (130), a first limiting block (131) is formed in the limiting rotation shaft hole (130), the cover body (200) is provided with a limiting rotation shaft (220) matched with the limiting rotation shaft hole (130), the limiting rotation shaft (220) is far away from one end of the cover body (200) and is provided with a second limiting block (221) matched with the first limiting block (131), the first limiting block (131) is far away from the end face of the cover body (200) and the top face of the limiting rotation shaft hole (130) and is equal to the distance between the end face of the cover body (200) and the second limiting block (221) is close to the end face of the cover body (200).

9. An implantable sensor skin anchor according to claim 2, wherein: keep away from on installation department (110) the side shaping of fixed slot (120) has locking elastic block (140), locking elastic block (140) are kept away from the one end of installation department (110) extends to be close to the edge of base (100), on the lateral wall of installation cavity (210) its relevant position shaping has complex buckle seat (212) with it.

10. An implantable sensor skin anchor according to claim 6, wherein: a bump (150) is formed at the edge of the base (100) far away from the limiting rotation shaft hole (130), a clamping groove (151) is formed in the side face of the bump (150), and a clamping block (230) matched with the cover body (200) is formed at the corresponding position of the cover body.