CN112426500A - 一种治疗宫颈癌的中药组合物 - Google Patents
一种治疗宫颈癌的中药组合物 Download PDFInfo
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Abstract
本发明公开了一种治疗宫颈癌的中药，是由下列重量份的原料药组成：苦丁香、啤酒花3～6重量份；泽芬、见肿消、桑白皮、金铃子5～10重量份；千层菊、血龙藤、益智9～18重量份；节节花15～30重量份；开金锁20～40重量份。本发明可以增强机体免疫功能，杀死宫颈癌细胞、诱导宫颈癌细胞分化和凋亡、防止宫颈癌细胞转移，减轻患者痛苦、提高病人生存质量，提高了宫颈癌患者的治愈率，具有治疗效果显著、无毒副作用等特点。
Description
技术领域
本发明涉及中药的制备领域，特别是涉及一种治疗宫颈癌的中药组合物。
背景技术
宫颈癌是最常见的妇科恶性肿瘤。原位癌高发年龄为30～35岁，浸润癌为45～55岁，近年来其发病有年轻化的趋势。
传统治疗方法有种种缺陷，手术治疗能将肿瘤切除，但是，手术风险高，手术对人体创伤大，使患者免疫力降低，对疾病抵抗力下降，手术为局部治疗手段，只适用于早期且身体状况能够耐受的患者；手术切除不能除根，会直接导致宫颈癌细胞扩散。
化疗药物几乎都是细胞毒性药物，在杀死肿瘤细胞的同时，对人体的正常细胞有一定的毒副作用，尤其是对分裂、增殖、比较快的细胞如骨髓造血细胞、胃肠道粘膜上皮细胞等。化疗会缩短患者生存时间且部分肿瘤对药物不敏感，化疗不可能彻底杀死体内所有宫颈癌细胞，在一定的时间内宫颈癌细胞还会复发或转移。
放射治疗常作为一种辅助治疗或姑息治疗手段。放射治疗在破坏肿瘤的同时，正常组织细胞也会受到一定的损害，超过这一限制剂量就会对组织产生不可逆损害，而且，放射治疗还可能降低机体的免疫力。放射的剂量是经过理论计算来完成，难以与实际相符合，只有小于 2cm 的肿瘤才能一次性完全破坏。
发明内容
本发明的目的在于改进已有技术的不足而提供一种治疗宫颈癌的中药组合物，使其可以有效的抵抗宫颈癌细胞、防止宫颈癌细胞转移，提高了宫颈癌患者的治愈率，具有治疗效果显著、无毒副作用等特点。
本发明提供了一种治疗宫颈癌的中药组合物，该中药组合物包括：苦丁香、啤酒花3～6重量份；泽芬、见肿消、桑白皮、金铃子5～10重量份；千层菊、血龙藤、益智9～18重量份；节节花15～30重量份；开金锁20～40重量份。
在一个优选的实施方案中，所述治疗宫颈癌的中药组合物由下列重量份的原料药组成：苦丁香、啤酒花6重量份；泽芬、见肿消、桑白皮、金铃子10重量份；千层菊、血龙藤、益智18重量份；节节花30重量份；开金锁40重量份。
其中，苦丁香：味苦；性寒；有毒。归脾；胃；肝经。涌吐痰食；除湿退黄。体外实验证实苦丁香所含葫芦苦素B、D、E、I对人宫颈癌有强效细胞毒作用。
开金锁：微辛、涩，凉。归肺经。清热解毒，排脓祛瘀。开金锁对颈癌杀死率分别为85.5%；对宫颈鳞癌HeLa细胞生长的抑制率分别为78.9%，使癌细胞的膜、RNA、DNA代谢、核分裂受损伤。
节节花：微苦、微酸，凉。清热解毒，利湿止痒。节节花特异性地杀死宫颈癌细胞，在极低的浓度下即可抑制宫颈癌细胞。
千层菊：苦、辛，微寒。归肝、心经。清热解毒。千层菊对人宫颈癌细胞具有直接细胞毒作用。
白芷：味辛；性温归肺；脾；胃经祛风除湿；通窃止痛；消肿排脓。白芷对人宫颈癌细胞具有直接细胞毒作用。
血龙藤：苦、甘，温。归肝、肾经。体外试验血龙藤对宫颈癌抑制率为94.4%。
见肿消：苦，微寒。归心、胃经。清热解毒，消痈散结。体外试验见肿消对宫颈癌抑制率为90%以上。
益智：甘，温。归心、脾经。补益心脾，养血安神。体外试验见肿消对宫颈癌抑制率为90%以上。
金铃子：苦，寒；有小毒。归肝、小肠、膀胱经。体外试验见肿消对宫颈癌抑制率为90%以上。
桑白皮：甘，寒。归肺经。泻肺平喘，利水消肿。桑白皮热水提取物体外试验，对人子宫颈癌JTC-26株的抑制率为70%左右，具有诱生干扰素作用。
啤酒花：苦；性微凉。归肝；胃经。健胃消食；利尿消肿；抗痨消炎。啤酒花能显著抑制内皮细胞增殖，具有显著抗肿瘤作用，是抑制各种肿瘤的血管形成疾病、恶性肿瘤生长和转移的有效药物。
本发明是由中国传统的中草药制成，根据中医辨证论治及现代医学的若干原则，以某些成分确定、功效明晰的天然提取物的有序配伍，组合成了有诱导宫颈癌细胞凋亡与促使其分化的中药。
本发明既有化学治疗之功，又平和无毒，可谓“零毒化疗”。 用药多年来，患者无任何不良反应，跟踪血液检查正常，且疗效不反弹。在二十例晚期宫颈癌的纯中医治疗中，治愈率40%，5年以上生存率55%，有效率100%。
本发明可以使各中药成分在发挥其抗癌作用的同时相互协同，相辅相成，可以起到相互促进的作用，既能抑制宫颈癌细胞的增值，又能杀死宫颈癌细胞诱导宫颈癌细胞凋亡，起到治疗宫颈癌的作用。本发明与手术治疗相结合可以促进患者康复，预防术后肿瘤的复发和转移，快速帮助患者康复。
本发明能够帮助晚期宫颈癌患者改善症状、减轻痛苦、提高病人生存质量。对于已复发或转移及无法进行西医手术、放化疗治疗的患者，通过单独服用本配方中药，增强机体免疫功能，诱导宫颈癌细胞分化和凋亡，也可以达到延长病人生命的作用，甚至有可能带瘤生存。
本发明所述的中药组合物可用于治疗宫颈癌，具有显著疗效。本发明治疗费用相对低廉，远远低于西医的治疗费用。
本发明的中药组合物原料易得，工艺简单，成本低，效率高，有利于制药企业进行药品生产、质量控制；产品价格低，易于被患者接受。
本发明还提供了一种由上述治疗该病的中药组合物制成的口服制剂，所述口服制剂包括口服液、片剂、胶囊剂、丸剂等，优选剂型为口服液和胶囊剂，一日一剂，分早晚两次服用。
本发明的中药组合物可以制备成多种剂型。例如，将煎煮后的药液杀菌消毒后装袋，制成口服液；或者将煎煮后的药液进行浓缩，烘干后，加入医学上可接收的辅料，然后制成片剂、胶囊剂、丸剂等。
所述医学上可接收的辅料包括淀粉、糊精、羧甲基纤维素钠、聚乙二醇、磷酸氢钙、海藻酸钠、山梨酸钾等。
以上所述，仅是本发明的较佳实施例而已，并非对本发明作任何形式上的限制，本领域技术人员利用上述揭示的技术内容做出些许简单修改、等同变化或修饰，均落在本发明的保护范围内。
Claims (4)
1.一种治疗宫颈癌的中药，其特征是由下列重量份的原料药组成：苦丁香、啤酒花3～6重量份；泽芬、见肿消、桑白皮、金铃子5～10重量份；千层菊、血龙藤、益智9～18重量份；节节花15～30重量份；开金锁20～40重量份。
2.根据权利要求1所述的一种治疗宫颈癌的中药，其特征是由下列重量份的原料药组成：苦丁香、啤酒花6重量份；泽芬、见肿消、桑白皮、金铃子10重量份；千层菊、血龙藤、益智18重量份；节节花30重量份；开金锁40重量份。
3.一种治疗宫颈癌的口服制剂，其特征是由权利要求1或2中任一项所述的中药组合物制成。
4.根据权利要求3所述的一种治疗宫颈癌的口服制剂，其特征是，所述口服制剂包括口服液、片剂、胶囊剂、丸剂，优选口服液和片剂。
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| CN102671129A (zh) * | 2012-05-21 | 2012-09-19 | 唐武 | 一种治疗宫颈癌的中药组合物 |
| CN106309749A (zh) * | 2016-10-12 | 2017-01-11 | 南宁多灵生物科技有限公司 | 一种治疗宫颈癌的中药 |
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| CN102671129A (zh) * | 2012-05-21 | 2012-09-19 | 唐武 | 一种治疗宫颈癌的中药组合物 |
| CN106309749A (zh) * | 2016-10-12 | 2017-01-11 | 南宁多灵生物科技有限公司 | 一种治疗宫颈癌的中药 |
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