CN112423875B - 表面改性的微胶囊 - Google Patents
表面改性的微胶囊 Download PDFInfo
- Publication number
- CN112423875B CN112423875B CN201980047281.7A CN201980047281A CN112423875B CN 112423875 B CN112423875 B CN 112423875B CN 201980047281 A CN201980047281 A CN 201980047281A CN 112423875 B CN112423875 B CN 112423875B
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- China
- Prior art keywords
- microcapsule
- polyquaternium
- modified
- composition
- moiety
- Prior art date
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Classifications
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- C09B67/00—Influencing the physical, e.g. the dyeing or printing properties of dyestuffs without chemical reactions, e.g. by treating with solvents grinding or grinding assistants, coating of pigments or dyes; Process features in the making of dyestuff preparations; Dyestuff preparations of a special physical nature, e.g. tablets, films
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Abstract
制备微胶囊组合物的方法包括以下步骤:(a)提供由具有伯胺或仲胺基团的囊封聚合物形成的微胶囊,(b)提供具有反应性基团的沉积剂,以及(c)在伯胺或仲胺基团和反应性基团之间形成共价键以将沉积剂接枝到囊封聚合物。还公开了含有这些微胶囊的消费品。
Description
背景
纳米或微囊封用于其中需要将包括香精、香料和恶臭中和剂的活性材料以时间延迟或受控的方式递送、应用或释放到目标区域的多种不同应用。
已知的聚脲或聚氨酯胶囊面临多重问题,例如固体表面上的低沉积率、低嗅觉强度和低稳定性。
将微胶囊改性以实现某些目的。US 8,586,143描述了将微胶囊接枝到纤维或纺织品上以产生功能性制品。微胶囊被永久地连接至纤维或纺织品。US 8,586,143中描述的接枝方法不适于将香精微胶囊改性以改善在冲洗型(wash-off)或免洗型(leave-on)消费品中在皮肤、头发、家具表面上的沉积。
存在开发用于洗衣、洗涤、清洁、表面护理以及个人和皮肤护理的稳定且高效的微胶囊的需求。对于这样的应用,需要微胶囊的高沉积率。
发明概述
本发明基于这样的发现:可以将某些胶囊化学改性以改善消费品中的沉积率和嗅觉强度。
因此,本发明的一个方面涉及制备微胶囊组合物的方法。所述方法包括以下步骤:(a)提供含有多个微胶囊的微胶囊浆料,其中每个微胶囊具有微胶囊芯和囊封微胶囊芯的微胶囊壁,并且具有内表面和外表面的微胶囊壁由具有伯胺或仲胺基团的囊封聚合物形成,(b)提供具有反应性基团的沉积剂,以及(c)在伯胺或仲胺基团和反应性基团之间形成共价键以将沉积剂接枝到微胶囊壁的外表面上的囊封聚合物,以获得表面改性的微胶囊。
在这种方法中,沉积剂含有季铵部分、氧代咪唑烷基部分、儿茶酚部分、羧酸部分、烷基部分或其组合,并且微胶囊芯含有香精。沉积剂的实例包括缩水甘油基三甲基铵盐、N-(2-(2-氧代咪唑烷-1-基)乙基)甲基丙烯酰胺、N-(2-(2-氧代咪唑烷-1-基)乙基)丙烯酰胺、N-(3,4-二羟基苯乙基)甲基丙烯酰胺、3,4-二羟基苯甲醛、[3-(甲基丙烯酰基氨基)丙基]三甲基氯化铵、(3-丙烯酰胺基丙基)三甲基铵及其任意组合。
在一些实施方案中,反应性基团是环氧基团、丙烯酰基基团、甲基丙烯酰基基团或醛基团。
在其他实施方案中,囊封聚合物是由多异氰酸酯和多胺的反应获得的聚脲聚合物。优选的多胺包括支化聚乙烯亚胺、线型聚乙烯亚胺、聚乙烯胺、胺改性的聚乙烯胺、氨端聚二甲基硅氧烷(amodimethicone)及其任意组合。
囊封聚合物还可以是三聚氰胺-甲醛聚合物、聚丙烯酸酯聚合物或二氧化硅聚合物。
在任一种上述方法中,微胶囊浆料优选地含有游离的支化聚乙烯亚胺,沉积剂与其反应以形成改性的聚乙烯亚胺。
任选地,微胶囊芯还含有前香精(pro-fragrance)、香料、恶臭中和剂、维生素或其衍生物、抗炎剂、杀真菌剂、麻醉剂、止痛剂、抗微生物活性成分(antimicrobial active)、抗病毒剂、抗感染剂、祛痘剂、皮肤光亮剂、驱昆虫剂(insect repellant)、兽用驱避剂(animal repellent)、驱寄生虫剂(vermin repellent)、软化剂(emollient)、皮肤保湿剂、皱纹控制剂、UV防护剂、织物柔顺剂活性成分(fabric softener active)、硬表面清洁活性成分(hard surface cleaning active)、皮肤或头发调理剂、阻燃剂、抗静电剂、纳米至微米尺寸的无机固体、聚合物或弹性体颗粒、味道调节剂、细胞、益生菌或其组合。
本发明的另一个方面涉及通过任一种上述方法制备的微胶囊组合物。这些微胶囊组合物还可以包含游离沉积助剂,所述沉积助剂选自由以下各项组成的组:聚季铵盐-4、聚季铵盐-5、聚季铵盐-6、聚季铵盐-7、聚季铵盐-10、聚季铵盐-16、聚季铵盐-22、聚季铵盐-24、聚季铵盐-28、聚季铵盐-39、聚季铵盐-44、聚季铵盐-46、聚季铵盐-47、聚季铵盐-53、聚季铵盐-55、聚季铵盐-67、聚季铵盐-68、聚季铵盐-69、聚季铵盐-73、聚季铵盐-74、聚季铵盐-77、聚季铵盐-78、聚季铵盐-79、聚季铵盐-80、聚季铵盐-81、聚季铵盐-82、聚季铵盐-86、聚季铵盐-88、聚季铵盐-101、聚乙烯胺、聚乙烯亚胺、聚乙烯胺和乙烯甲酰胺共聚物及其组合。与沉积剂不同,这些游离沉积助剂中的每一个在微胶囊组合物中是独立的,并且不共价连接至微胶囊的表面。
本发明的另一个方面涉及表面改性的微胶囊,所述微胶囊包含微胶囊芯和囊封微胶囊芯的微胶囊壁,其中微胶囊芯含有香精,微胶囊壁由聚脲聚合物形成并且具有内表面和外表面,内表面与微胶囊芯接触,外表面具有每一个经由共价键连接至外表面的一个或多个沉积基团,并且沉积基团中的每一个独立地含有季铵部分、氧代咪唑烷基部分、儿茶酚部分、羧酸部分或烷基部分。共价键可以是胺键(N-C)、亚胺键(N=C)、醚键(O-C)、酰胺键(-C(O)N-)或酯键(-C(O)O-)。
表面改性的微胶囊的尺寸(以直径计)通常在0.1微米至1000微米之间变化。优选的聚脲聚合物是支化聚乙烯亚胺和多异氰酸酯的反应产物。示例性的多异氰酸酯包括六亚甲基二异氰酸酯的三聚体、异佛尔酮二异氰酸酯的三聚体、六亚甲基二异氰酸酯的缩二脲、甲苯二异氰酸酯的聚异氰脲酸酯、甲苯二异氰酸酯的三羟甲基丙烷加合物、苯二甲撑二异氰酸酯的三羟甲基丙烷加合物及其组合。
表面改性的微胶囊任选地还包含胶囊形成助剂,所述胶囊形成助剂选自由以下各项组成的组:聚乙烯醇、胺改性的聚乙烯胺、聚磺苯乙烯、羧甲基纤维素、多糖、季铵化多糖、氨端聚二甲基硅氧烷、萘磺酸盐缩合物盐、聚乙烯吡咯烷酮、乙烯吡咯烷酮和季铵化甲基丙烯酸二甲基氨基乙酯的共聚物及其组合。另外,活性材料还可以含有前香精、香料、恶臭中和剂、维生素或其衍生物、抗炎剂、杀真菌剂、麻醉剂、止痛剂、抗微生物活性成分、抗病毒剂、抗感染剂、祛痘剂、皮肤光亮剂、驱昆虫剂、兽用驱避剂、驱寄生虫剂、软化剂、皮肤保湿剂、皱纹控制剂、UV防护剂、织物柔顺剂活性成分、硬表面清洁活性成分、皮肤或头发调理剂、阻燃剂、抗静电剂、纳米至微米尺寸的无机固体、聚合物或弹性体颗粒、味道调节剂、细胞、益生菌或其组合。
制备改性的聚乙烯亚胺的方法也在本发明的范围内,所述方法包括以下步骤:(a)提供含有伯胺或仲胺基团的聚乙烯亚胺,(b)提供具有反应性基团的沉积剂,以及(c)在伯胺或仲胺基团和反应性基团之间形成共价键以将沉积剂接枝到聚乙烯亚胺,其中沉积剂和反应性基团如上定义。可用于本发明的聚乙烯亚胺包括支化聚乙烯亚胺和线型聚乙烯亚胺。
通过上述方法制备的改性的聚乙烯亚胺也在本发明的范围内。在一些实施方案中,改性的聚乙烯亚胺具有支化或线型的聚乙烯亚胺主链和沉积部分,其中沉积部分经由共价键连接至聚乙烯主链,并且沉积部分如上定义。
本发明还提供了包含微胶囊和改性的聚乙烯亚胺的微胶囊组合物。
本发明还包括含有任一种上述微胶囊组合物的消费品。示例性的消费品包括:洗发剂、护发剂、染发剂、头发清新剂、头发固定或定型助剂、头发漂白剂、头发染料或着色剂、肥皂、沐浴液、化妆品制备物、通用清洁剂、浴厕清洁剂、地板清洁剂、窗户清洁剂、浴巾、纸巾、一次性擦拭巾、尿布疹乳膏或护臀膏、婴儿爽身粉、尿不湿、围嘴、婴儿擦拭巾、口腔护理产品、牙膏、漱口水、牙齿增白剂、义齿粘附剂、口香糖、口气清新剂、口腔可溶条、咀嚼糖、硬糖、洗手液、抗炎香油、抗炎软膏、抗炎喷雾剂、保健设备、牙线、牙刷、卫生棉塞、卫生巾、个人护理产品、防晒乳液、防晒喷雾剂、基于蜡的除臭剂、二醇型除臭剂、皂型除臭剂、面部乳液、身体乳液、手部乳液、爽身粉、剃须膏、浸浴用品、去角质磨砂膏、足霜、面巾、清洁擦拭巾、织物护理产品、织物柔顺剂、织物清新剂、熨烫水、液体衣物洗涤剂、液体碗碟洗涤剂、自动碗碟洗涤剂、单位剂量片剂或胶囊、增味剂(scent booster)、烘干纸(drier sheet)、精制香精(fine fragrance)、固体香料、粉末粉底、液体粉底、眼影、唇膏或润唇膏、淡香水产品(Eau De Toilette product)、除臭剂、地毯除臭剂、蜡烛、房间除臭剂、消毒剂(disinfectant)、止汗剂、滚抹式产品(roll-on product)和气溶胶产品。
本发明的一个或多个实施方案的细节在以下描述中说明。本发明的其他特征、目的和优点根据说明书和权利要求书将是明显的。
发明详述
已经发现某些表面改性的微胶囊出乎意料地在硬表面(诸如皮肤、头发、布、家具等)上具有高沉积率。这些表面改性的微胶囊已经成功地并入许多消费应用中。
示例性的应用包括:个人头发护理产品,诸如洗发剂和护发剂;个人洗涤用品(personal washes),诸如肥皂、沐浴液、个人清洁剂和消毒剂(sanitizer);织物护理品,诸如织物清新剂、柔顺剂和烘干纸;熨烫水;工业清洁剂;液体和粉末洗涤剂;漂洗调理剂(rinse conditioner);精制香精;淡香水产品;除臭剂;滚抹式产品;和气溶胶产品。本发明的表面改性的微胶囊还良好地适合在水醇介质诸如精制香精中使用和在免洗型个人护理应用中使用。
本发明的表面改性的微胶囊各自具有微胶囊芯和囊封微胶囊芯的微胶囊壁。
微胶囊芯含有活性材料(例如,香精)。
微胶囊壁由聚脲聚合物形成并且具有内表面和外表面。内表面与微胶囊芯接触。外表面具有各自经由共价键连接至外表面的一个或多个沉积基团。沉积基团中的每一个独立地含有季铵部分、氧代咪唑烷基部分、儿茶酚部分、羧酸部分或烷基部分。
本发明的表面改性的微胶囊各自具有0.1微米至1000微米(例如,0.5微米至500微米、1微米至200微米和1微米至100微米)的粒度(以直径计),其中下限为0.1微米、0.5微米、1微米、2微米和5微米,并且上限为1000微米、500微米、200微米、100微米、75微米、50微米和30微米。
表面改性的微胶囊可以是带正电荷的,其中ζ电位为至少10mV(例如,25mV以上、40mV以上、25-200mV和40-100mV)。不受理论的束缚,由此改性的微胶囊出乎意料地对特定的有生命和无生命的表面(例如,头发和织物)具有强亲和力,并且在消费品基质(诸如护发剂、洗发剂、沐浴露和织物调理剂)中也是稳定的。
本发明的表面改性的微胶囊可以通过包括以下步骤的方法制备:(a)提供含有多个微胶囊的微胶囊浆料,其中每个微胶囊具有微胶囊芯和囊封微胶囊芯的微胶囊壁,并且具有内表面和外表面的微胶囊壁由具有伯胺或仲胺基团的囊封聚合物形成,(b)提供具有反应性基团的沉积剂,以及(c)在伯胺或仲胺基团和反应性基团之间形成共价键以将沉积剂接枝到微胶囊壁的外表面上的囊封聚合物以获得表面改性的微胶囊,其中沉积剂如上定义,并且微胶囊芯含有香精。
微胶囊浆料可以通过在胶囊形成助剂(例如,分散剂)和/或催化剂(例如,碱)的存在下使多官能亲核试剂与多官能亲电子试剂反应(例如,经由界面聚合)使得活性材料被微胶囊壁囊封在油芯中来制备。油芯任选地含有芯改性剂(core modifier)。微胶囊壁由作为多官能亲核试剂和多官能亲电子试剂的反应产物的囊封聚合物形成。优选地,囊封聚合物是支化聚乙烯亚胺(多官能亲核试剂)与芳族/脂族多异氰酸酯(多官能亲电子试剂)的反应产物。
多官能亲核试剂。
多官能亲核试剂是支化聚乙烯亚胺或者含有支化聚乙烯亚胺和多官能胺/醇的混合物。在一个优选的实施方案中,多官能亲核试剂是支化聚乙烯亚胺。
合适的支化聚乙烯亚胺各自具有200至1,000,000(例如,300至500,000、500至200,000、750至100,000和750至50,000)的分子量(例如,重均分子量,Mw)。平均分子量范围可以通过光散射确定,如Barth H.G.和Mays J.W.Chemical Analysis第113卷,“ModernMethods of Polymer Characterization”所描述的。
支化聚乙烯亚胺具有主链和连接至主链的一个或多个侧链。主链具有2至25,000个(例如,3至10,000个、5至5000个和5至500个)重复亚乙基胺(-CH2CH2NH-)单元。侧链各自具有一个或多个亚乙基胺末端(-CH2CH2NH2)。支化聚乙烯亚胺的代表性结构如下所示:
其中n为1至5000(例如,1至2000、1至1000和1至100)。
其他合适的多官能亲核试剂包括多官能胺(例如,多胺、两性胺、氨基酸、肽和蛋白质)和多官能醇(例如,多元醇)。
多官能胺是具有至少伯胺或仲胺基团(-NH2和-NH-)以及一个或多个另外的官能团如伯胺或仲胺和羟基基团(-OH)的那些。示例性的多官能胺包括六亚甲基二胺、六亚乙基二胺、乙二胺、1,3-二氨基丙烷、1,2-二氨基丙烷、1,4-二氨基丁烷、二亚乙基三胺、五亚乙基六胺、双(3-氨基丙基)胺、双(六亚甲基)三胺、三(2-氨基乙基)胺、三亚乙基四胺、N,N′-双(3-氨基丙基)-1,3-丙二胺、N,N,N’,N’-四(2-羟乙基)乙二胺、N,N,N’,N’-四(2-羟丙基)乙二胺、2,4-二氨基-6-羟基嘧啶、2,4,6-三氨基嘧啶、四亚乙基五胺、氨基-2-甲基-1-丙醇、第二支化聚乙烯亚胺和壳聚糖。胍胺和胍盐是用于本发明的又一类多官能胺。示例性的胍胺和胍盐包括但不限于1,3-二氨基胍及其单盐酸盐、1,1-二甲基双胍及其盐酸盐、碳酸胍和盐酸胍。
合适的多胺含有两个以上胺基团(诸如-NH2和-R*NH,R*是取代和未取代的C1-C20烷基、C1-C20杂烷基、C1-C20环烷基、3至8元杂环烷基、芳基和杂芳基)。这些多胺包括聚亚烷基多胺和聚醚胺,如WO 2015/023961 A1所述。
两性胺(即可以作为酸和碱反应的胺)是用于本发明的另一类胺。实例包括蛋白质和氨基酸,诸如L-赖氨酸、D-赖氨酸、L-精氨酸、D-精氨酸、L-赖氨酸单盐酸盐、D-赖氨酸单盐酸盐、L-精氨酸单盐酸盐、D-精氨酸单盐酸盐、组氨酸、L-鸟氨酸单盐酸盐、D-鸟氨酸单盐酸盐、乳酸链球菌肽(nisin)、明胶及其混合物。
可商购获得的胺的实例包括以商标EDR-148(其中x=2)、EDR-176(其中x=3)(来自Huntsman)销售的产品。其他聚醚胺包括ED系列、/>TRIAMINES、来自巴斯夫(BASF)(路德维希港(Ludwigshafen),德国)的商标为/>的聚乙烯亚胺(例如,/>FG、G20无水(waterfree)、/>PR 8515、/>WF、/>FC、G20、/>G35、/>G100、/>G500、/>HF、PS、/>HEO 1、/>PN50、/>PN60、/>PO100和SK)。其他可商购获得的聚乙烯亚胺包括由NIPPON SHOKUBAI(纽约,NY)以商标P-1000、/>P-1050、/>RP18W和/>PP-061销售的产品。还可以使用聚乙烯胺,诸如巴斯夫(BASF)以商标/>销售的那些。本领域技术人员可以选择宽范围的聚醚胺。
多官能醇是具有两个以上羟基的那些。非限制性实例是季戊四醇、葡萄糖、2-氨基乙醇、二季戊四醇、甘油、聚甘油、乙二醇、己二醇、聚乙二醇、三羟甲基丙烷、新戊二醇、山梨糖醇、赤藓糖醇、苏糖醇、阿拉伯糖醇、木糖醇、核糖醇、甘露糖醇、半乳糖醇、岩藻糖醇、艾杜糖醇(iditol)、肌醇、庚七醇(volemitol)、异麦芽糖醇(isomalt)、麦芽糖醇、乳糖醇、麦芽三糖醇(maltotriitol)、麦芽四糖醇(maltotetraitol)、聚葡萄糖糖醇(polyglycitol)及其组合。WO 2015/023961A1中描述了更多合适的多官能醇。
如本发明中所使用的多官能亲核试剂可以是单一化合物(例如,支化聚乙烯亚胺)或者两种以上多官能胺(例如,支化聚乙烯亚胺与一种或多种多官能胺/醇)的混合物。
按微胶囊的重量计,多官能亲核试剂含量的范围可以从0.1%至15%(例如,0.2%至10%、0.5%至8%、1%至8%和2%至6%)变化。当将微胶囊掺入微胶囊组合物中时,按微胶囊组合物的重量计,多官能亲核试剂以0.05%至8%(例如,0.1%至5%、0.1%至4%、0.25%至4%和0.25%至3%)的水平存在。
在一个实施方案中,在0℃至55℃(例如,10-50℃、15-45℃、20-40℃和25-35℃)的温度下将多官能亲核试剂添加至聚合反应。
多官能亲电子试剂
多官能亲电子试剂具有至少两个对支化聚乙烯亚胺、多官能胺或多官能醇具有反应性的亲电子官能团,以形成囊封聚合物的网络。亲电子基团的实例包括甲酰基、酮基(keto)、羧基、异氰酸酯基团、羧酸酯基团、酰基卤基团、酰胺基团、羧酸酐基团、烷基卤基团、环氧基团、氮杂环丙烷(aziridine)基团、氧杂环丁烷(oxetane)基团、氮杂环丁烷(azetidine)基团、磺酰卤基团、氯磷酸酯基团、α,β-不饱和羰基、α,β-不饱和腈基团、三氟甲磺酸酯基团、对甲苯磺酸酯基团和α,β-不饱和甲磺酰基。
合适的多官能亲电子试剂包括戊二醛、丁二醛(succinic dialdehyde)和乙二醛;以及化合物如乙二醛(glyoxyl)三聚体和多聚甲醛、双(二甲基)缩醛、双(二乙基)缩醛、聚二醛,诸如氧化淀粉。其他合适的多官能亲电子试剂是低分子量、双官能的醛,诸如乙二醛、1,3-丙二醛、1,4-丁二醛、1,5-戊二醛或1,6-己二醛(hexane)。
优选地,多官能亲电子试剂为多官能异氰酸酯(即,多异氰酸酯),其各自含有两个以上异氰酸酯(-NCO)基团。这些多异氰酸酯可以是芳族的、脂族的、线型的、支链的或环状的。在一些实施方案中,多异氰酸酯平均含有2至4个异氰酸酯基团。在特别的实施方案中,多异氰酸酯含有至少三个异氰酸酯官能团。在某些实施方案中,多异氰酸酯是水不溶性的。
在特别的实施方案中,本发明中所使用的多异氰酸酯是芳族多异氰酸酯。理想地,芳族多异氰酸酯包括作为芳香组分的苯基、甲苯基、二甲苯基、萘基或二苯基(diphenyl)部分。在某些实施方案中,芳族多异氰酸酯是甲苯二异氰酸酯的聚异氰脲酸酯、甲苯二异氰酸酯的三羟甲基丙烷加合物或苯二甲撑二异氰酸酯的三羟甲基丙烷加合物。
一类合适的芳族多异氰酸酯是具有如下所示的一般结构的那些,及其结构异构体
其中取决于所使用的多胺或多元醇的类型,n可以从零至所需数量(例如,0-50、0-20、0-10和0-6)变化。优选地,将n的数量限制为小于6。起始多异氰酸酯还可以是多异氰酸酯的混合物,其中n的值可以从0至6变化。在起始多异氰酸酯是多种多异氰酸酯的混合物的情况下,n的平均值优选地落入在0.5至1.5之间。可商购获得的多异氰酸酯包括以如下商标销售的产品:M20(化学名:聚亚甲基二苯基二异氰酸酯,即“PMDI”;可从巴斯夫(BASF)商购获得,含有31.5重量%的异氰酸酯基团“NCO”),其中平均值n是0.7;27(可从陶氏化学(Dow Chemical)商购获得的具有340的平均分子量并且含有31.4重量%的NCO的PMDI),其中平均值n是0.7;/>MR(含有31重量%以上的NCO的PMDI,可从科思创,匹兹堡,宾夕法尼亚州(Covestro,Pittsburg,Pennsylvania)商购获得),其中平均值n是0.8;/>MR Light(含有31.8重量%的NCO的PMDI,可从科思创商购获得),其中平均值n是0.8;/>489(可从科思创商购获得的含有30-31.4重量%的NCO的PMDI),其中平均值n是1;聚[(苯基异氰酸酯)-共-甲醛](奥德里奇化学,密尔沃基,WI(Aldrich Chemical,Milwaukee,WI)),其他异氰酸酯单体,如商标为N3200(可从科思创商购获得的聚(六亚甲基二异氰酸酯))、TakenateTMD-110N(苯二甲撑二异氰酸酯的三羟甲基丙烷加合物,三井化学美国有限公司(MitsuiChemicals America,Inc.),Rye Brook,NY,含有11.5重量%的NCO)、/>L75(可从科思创商购获得的基于甲苯二异氰酸酯的多异氰酸酯)和/>IL(可从科思创商购获得的基于甲苯二异氰酸酯的另一多异氰酸酯)的产品。
本发明的某些可商购获得的多异氰酸酯的结构如下所示:
或其结构异构体。R可以是C1-C10烷基、C1-C10酯或异氰脲酸酯。代表性的具有此结构的多异氰酸酯是以商标TakenateTM D-110N(三井(Mitsui))、L75(科思创)和/>IL(科思创)销售的产品。
多异氰酸酯诸如以商标TakenateTM D-110N销售的产品和其他多异氰酸酯是可商购获得的,典型地以乙酸乙酯溶液获得。优选地,将乙酸乙酯替换为具有高闪点(例如,至少100℃、至少120℃和至少150℃)的溶剂。合适的溶剂包括三醋精(triacetin)、柠檬酸三乙酯、乙二醇二乙酸酯、苯甲酸苄酯及其组合。
作为示例,商标为TakenateTM D-110N(苯二甲撑二异氰酸酯的三羟甲基丙烷加合物在乙酸乙酯中的溶液)的商业产品与苯甲酸苄酯组合并且真空蒸馏以移除乙酸乙酯,以获得含有约59%的苯二甲撑二异氰酸酯的三羟甲基丙烷加合物溶液和41%的苯甲酸苄酯的多异氰酸酯溶液。该多异氰酸酯溶液的闪点为至少60℃。这种苯甲酸苄酯中的多异氰酸酯溶液连同聚乙烯吡咯烷酮(PVP)/聚季铵盐-11(PQ-11)或聚磺苯乙烯/羧甲基纤维素(CMC)可以用于制备本发明的微胶囊组合物。
芳族多异氰酸酯的其他实例包括1,5-萘二异氰酸酯,4,4’-二苯基甲烷二异氰酸酯(MDI),氢化MDI(H12MDI),苯二甲撑二异氰酸酯(XDI),四甲基二甲苯二异氰酸酯(TMXDI),4,4’-二苯基二甲基甲烷二异氰酸酯,二和四烷基二苯基甲烷二异氰酸酯,4,4’-二苄基二异氰酸酯,1,3-苯二异氰酸酯,1,4-苯二异氰酸酯,甲苯二异氰酸酯(TDI)的异构体,4,4’-二异氰酸基苯基全氟乙烷,邻苯二甲酸双异氰酸基乙酯,以及具有反应性卤原子的多异氰酸酯,如1-氯甲基苯基2,4-二异氰酸酯、1-溴甲基-苯基2,6-二异氰酸酯和3,3-双氯甲基醚4,4’-二苯基二异氰酸酯,及其组合。
在其他具体的实施方案中,多异氰酸酯是脂族多异氰酸酯,诸如六亚甲基二异氰酸酯的三聚体、异佛尔酮二异氰酸酯的三聚体和六亚甲基二异氰酸酯的缩二脲。示例性的脂族多异氰酸酯包括可商购获得的那些,例如可以以下商标商购获得的那些:N304和/>N305,其是基于六亚甲基二异氰酸酯的脂族的水可分散的多异氰酸酯;/>N3600、/>N3700和N3900,其是基于六亚甲基二异氰酸酯的低粘度多官能脂族多异氰酸酯;以及/>3600和/>N100,其是基于六亚甲基二异氰酸酯的脂族多异氰酸酯,其中的每种都可从科思创,匹兹堡,PA(Covestro,Pittsburgh,PA)获得。更多的实例包括1-甲基-2,4-二异氰酸基环己烷、1,6-二异氰酸基-2,2,4-三甲基己烷、1,6-二异氰酸基-2,4,4-三甲基己烷、1-异氰酸基甲基-3-异氰酸基-1,5,5-三甲基环己烷、氯化和溴化的二异氰酸酯、含磷的二异氰酸酯、四甲氧基丁烷1,4-二异氰酸酯、丁烷1,4-二异氰酸酯、己烷1,6-二异氰酸酯(HDI)、二环己基甲烷二异氰酸酯、环己烷1,4-二异氰酸酯、亚乙基二异氰酸酯及其组合。含硫多异氰酸酯例如通过使六亚甲基二异氰酸酯与硫二甘醇或二羟基二己基硫化物反应来获得。另外的合适的二异氰酸酯是三甲基六亚甲基二异氰酸酯、1,4-二异氰酸基丁烷、1,2-二异氰酸基十二烷、二聚体脂肪酸二异氰酸酯及其组合。
可用于本发明的多异氰酸酯的重均分子量从250道尔顿至1000道尔顿并且优选从275道尔顿至500道尔顿变化。
按微胶囊的重量计,多官能亲核试剂(例如,多异氰酸酯)含量的范围可以从0.2%至40%(例如,0.4%至35%、0.5%至30%、1%至25%、2%至25%和5%至20%)变化。当将微胶囊掺入微胶囊组合物中时,多异氰酸酯的量从0.1%至20%、优选从0.1%至15%、更优选从0.2%至10%并且甚至更优选从1.5%至3.5%变化,所有都基于总的胶囊组合物。
在一些实施方案中,用于制备本发明的微胶囊的多官能异氰酸酯是单一多异氰酸酯。在其他实施方案中,多异氰酸酯是多异氰酸酯的混合物。在一些实施方案中,多异氰酸酯的混合物包括脂族多异氰酸酯和芳族多异氰酸酯。在特别的实施方案中,多异氰酸酯的混合物是六亚甲基二异氰酸酯的缩二脲和苯二甲撑二异氰酸酯的三羟甲基丙烷加合物。在某些实施方案中,多异氰酸酯是脂族异氰酸酯或脂族异氰酸酯的混合物,不含任何芳族异氰酸酯。换言之,在这些实施方案中,不使用芳族异氰酸酯制备作为胶囊壁材料的聚脲/聚氨酯聚合物。
合适的多异氰酸酯的更多实例可以在WO 2004/054362和WO 2017/192648中找到。
胶囊形成助剂
微胶囊组合物典型地在胶囊形成助剂的存在下制备,胶囊形成助剂可以是表面活性剂或分散剂。胶囊形成助剂还改善微胶囊组合物的性能。性能通过特定阶段(例如,洗衣应用中的揉搓前和揉搓后阶段)期间释放的香精的强度来测定。揉搓前阶段是胶囊已经沉积在布上的阶段,例如在使用含有胶囊的织物柔顺剂或洗涤剂的洗涤循环之后。揉搓后阶段是在胶囊已经沉积并且通过摩擦或其他类似机制使胶囊破裂之后。
在一些实施方案中,胶囊形成助剂是保护胶体或乳化剂,包括例如马来酸-乙烯基共聚物如乙烯基醚与马来酸酐或马来酸的共聚物、木质素磺酸钠、马来酸酐/苯乙烯共聚物、乙烯/马来酸酐共聚物、以及环氧丙烷和环氧乙烷的共聚物、聚乙烯吡咯烷酮(PVP)、聚乙烯醇(PVA)、萘磺酸盐缩合物的钠盐、羧甲基纤维素(CMC)、聚氧乙烯化山梨糖醇的脂肪酸酯、十二烷基硫酸钠及其组合。按胶囊组合物的重量计,胶囊形成助剂(例如,表面活性剂和分散剂)的浓度从0.1%至5%(例如,0.2%至4%、0.5%至4%、0.5%至2.5%和1%至2%)变化。
可商购获得的表面活性剂包括但不限于:磺化的萘-甲醛缩合物,诸如商标为D-425的产品(烷基萘磺酸盐甲醛缩合物的钠盐,可从Akzo Nobel,FortWorth,Texas商购获得);部分水解的聚乙烯醇,诸如商标为/>的商品,例如MOWIOL 3-83(可从Kuraray,Houston,Texas商购获得);环氧乙烷-环氧丙烷嵌段共聚物或泊洛沙姆,诸如商标为/>或/>材料的产品(巴斯夫(BASF));磺化的聚苯乙烯,诸如以商标/>II(Akzo Nobel)销售的产品;乙烯-马来酸酐聚合物,诸如以商标/>(Vertellus Specialties Inc.,Indianapolis,Indiana)销售的产品;和聚季铵盐系列,诸如聚季铵盐-11(“PQ11”;乙烯吡咯烷酮和季铵化的甲基丙烯酸二甲基氨基乙酯的共聚物;由巴斯夫(BASF)以商标PQ11AT 1销售)。
加工助剂也可以用作胶囊形成助剂。它们包括水胶体,其改善浆料针对凝聚、沉降和乳状分层(creaming)的胶体稳定性。术语“水胶体”是指广义类的具有阴离子的、阳离子的、两性离子的或非离子的特征的水溶性或水可分散性聚合物。可用于本发明的水胶体包括但不限于多糖,如淀粉、改性淀粉、糊精、麦芽糖糊精和纤维素衍生物、以及它们的季铵化形式;天然树胶,如藻酸酯、角叉菜胶、黄原胶(xanthanes)、琼脂-琼脂、果胶(pectines)、果胶酸和天然树胶如阿拉伯树胶、黄蓍胶和刺梧桐胶、瓜尔胶和季铵化的瓜尔胶;明胶(gelatine)、蛋白质水解产物和它们的季铵化形式;合成的聚合物和共聚物,如聚(乙烯吡咯烷酮-共-乙酸乙烯酯)、聚(乙烯醇-共-乙酸乙烯酯)、聚((甲基)丙烯酸)、聚(马来酸)、聚((甲基)丙烯酸烷基酯-共-(甲基)丙烯酸)、聚(丙烯酸-共-马来酸)共聚物、聚(氧化烯烃)、聚(乙烯基甲基醚)、聚(乙烯基醚-共-马来酸酐)等,以及聚-(乙烯亚胺)、聚((甲基)丙烯酰胺)、聚(氧化烯烃-共-二甲基硅氧烷)、聚(氨基二甲基硅氧烷)等,以及它们的季铵化形式。
胶囊形成助剂在加工期间还可以与羧甲基纤维素(“CMC”)、聚乙烯吡咯烷酮、聚乙烯醇、烷基萘磺酸盐/酯甲醛缩合物和/或表面活性剂组合使用以促进胶囊形成。这些表面活性剂的实例包括鲸蜡基三甲基氯化铵(CTAC),泊洛沙姆诸如可以商标(例如,/>F127)、/>(例如,/>F127)或获得的商业产品,皂苷诸如/>(National Starch FoodInnovation);或阿拉伯树胶,诸如Seyal或Senegal。在某些实施方案中,CMC聚合物具有在90,000道尔顿至1,500,000道尔顿之间、优选在250,000道尔顿至750,000道尔顿之间并且更优选在400,000道尔顿至750,000道尔顿之间的分子量(例如,重均分子量)范围。CMC聚合物具有在0.1至3之间、优选在0.65至1.4之间并且更优选在0.8至1之间的取代度。CMC聚合物以0.1%至2%并且优选0.3%至0.7%的水平存在于胶囊浆料中。在其他实施方案中,本发明中使用的聚乙烯吡咯烷酮是水溶性聚合物,并且具有1,000道尔顿至10,000,000道尔顿的分子量(例如,重均分子量)。合适的聚乙烯吡咯烷酮是聚乙烯吡咯烷酮K12、K15、K17、K25、K30、K60、K90或其混合物。按微胶囊组合物的重量计,聚乙烯吡咯烷酮的量为2%至50%、5%至30%或10%至25%。
催化剂
适合用于本发明的催化剂是金属碳酸盐、金属氢氧化物、氨基或有机金属化合物,并且包括例如碳酸钠、碳酸铯、碳酸钾、氢氧化锂、1,4-二氮杂双环[2.2.2]辛烷(即DABCO)、N,N-二甲基氨基乙醇、N,N-二甲基环己胺、双-(2-二甲基氨基乙基)醚、N,N二甲基乙酰胺、辛酸锡和二月桂酸二丁基锡。
其他囊封聚合物
本发明的微胶囊组合物任选地具有第二、第三、第四、第五或第六微胶囊,其各自由选自由以下组成的组的囊封聚合物形成:溶胶-凝胶聚合物(例如,二氧化硅)、聚丙烯酸酯、聚丙烯酰胺、聚(丙烯酸酯-共-丙烯酰胺)、聚脲、聚氨酯、淀粉、明胶和阿拉伯树胶、聚(三聚氰胺-甲醛)、聚(脲-甲醛)及其组合。支化聚乙烯亚胺及其衍生物还可以涂覆到微胶囊壁上以制备具有正ζ电位的微胶囊。
下面详细描述这些囊封聚合物。
溶胶-凝胶微胶囊。这些微胶囊具有由溶胶-凝胶聚合物形成的微胶囊壁,所述溶胶-凝胶聚合物是溶胶-凝胶前体经由聚合反应(例如,水解)的反应产物。合适的溶胶-凝胶前体是能够形成凝胶的化合物,如含有硅、硼、铝、钛、锌、锆和钒的化合物。优选的前体是有机硅、有机硼和有机铝,包括金属醇化物和b-二酮化物(b-diketonate)。
适用于本发明的目的的溶胶-凝胶前体特别地选自以下各项的组:二、三和/或四官能的硅酸、硼酸和铝酯(alumoester),更特别地烷氧基硅烷(原硅酸烷基酯)及其前体。
适用于本发明的目的的溶胶-凝胶前体的一个实例是对应于以下通式的烷氧基硅烷:
(R1O)(R2O)M(X)(X’),
其中X可以是氢或-OR3;X’可以是氢或-OR4;并且R1、R2、R3和R4独立地表示有机基团,更特别地是直链或支链的烷基,优选C1-C12烷基。M可以是Si、Ti或Zr。
优选的溶胶/凝胶前体是对应于以下通式的烷氧基硅烷:(R1O)(R2O)Si(X)(X’),其中X、X’、R1和R2中的每一个如上定义。
特别优选的化合物是硅酸酯,如原硅酸四甲酯(TMOS)和原硅酸四乙酯(TEOS)。优选的化合物包括商标为的产品(可从Degussa Corporation,Parsippany NewJersey,USA商购获得的有机官能硅烷)。例如,在德国专利申请DE10021165中描述了适用于本发明的目的的其他溶胶-凝胶前体。这些溶胶-凝胶前体是各种可水解的有机硅烷,如例如烷基硅烷、烷氧基硅烷、烷基烷氧基硅烷和有机烷氧基硅烷。除烷基和烷氧基以外,其他有机基团(例如烯丙基、氨基烷基、羟基烷基等)也可以作为取代基连接至硅。
认识到金属和半金属醇化物单体(及其部分水解和缩合聚合物)如四甲氧基硅烷(TMOS)、四乙氧基硅烷(TEOS)等对于许多分子和活性成分是非常好的溶剂是非常有利的,因为其促进了以高浓度溶解活性材料并且由此促进在最终胶囊中的高负载。
聚丙烯酸酯微胶囊、聚丙烯酰胺微胶囊和聚(丙烯酸酯-共-丙烯酰胺)微胶囊。这些微胶囊由形成微胶囊壁的相应前体制备。优选的前体是双或多官能乙烯基单体,通过举例说明而不是限制,包括甲基丙烯酸烯丙酯/丙烯酰胺、二甲基丙烯酸三甘醇酯/丙烯酰胺、二甲基丙烯酸乙二醇酯/丙烯酰胺、二甲基丙烯酸二甘醇酯/丙烯酰胺、二甲基丙烯酸三甘醇酯/丙烯酰胺、二甲基丙烯酸四甘醇酯/丙烯酰胺、二甲基丙烯酸丙二醇酯/丙烯酰胺、二甲基丙烯酸甘油酯/丙烯酰胺、二甲基丙烯酸新戊二醇酯/丙烯酰胺、二甲基丙烯酸1,10-癸二醇酯/丙烯酰胺、三甲基丙烯酸季戊四醇酯/丙烯酰胺、四甲基丙烯酸季戊四醇酯/丙烯酰胺、六甲基丙烯酸二季戊四醇酯/丙烯酰胺、三烯丙基缩甲醛三甲基丙烯酸酯/丙烯酰胺、三羟甲基丙烷三甲基丙烯酸酯/丙烯酰胺、二甲基丙烯酸三丁二醇酯/丙烯酰胺、脂族或芳族尿烷二丙烯酸酯/丙烯酰胺、二官能尿烷丙烯酸酯/丙烯酰胺、乙氧基化脂族二官能尿烷甲基丙烯酸酯/丙烯酰胺、脂族或芳族尿烷二甲基丙烯酸酯/丙烯酰胺、环氧丙烯酸酯/丙烯酰胺、环氧甲基丙烯酸酯/丙烯酰胺、二丙烯酸1,3-丁二醇酯/丙烯酰胺、二甲基丙烯酸1,4-丁二醇(butaneidiol)酯/丙烯酰胺、二丙烯酸1,4-丁二醇酯/丙烯酰胺、二丙烯酸二甘醇酯/丙烯酰胺、二丙烯酸1,6-己二醇酯/丙烯酰胺、二甲基丙烯酸1,6-己二醇酯/丙烯酰胺、二丙烯酸新戊二醇酯/丙烯酰胺、聚乙二醇二丙烯酸酯/丙烯酰胺、二丙烯酸四甘醇酯/丙烯酰胺、二丙烯酸三甘醇酯/丙烯酰胺、二甲基丙烯酸1,3-丁二醇酯/丙烯酰胺、二丙烯酸三丙二醇酯/丙烯酰胺、乙氧基化双酚二丙烯酸酯/丙烯酰胺、乙氧基化双酚二甲基丙烯酸酯/丙烯酰胺、二丙烯酸二丙二醇酯/丙烯酰胺、烷氧基化己二醇二丙烯酸酯/丙烯酰胺、烷氧基化环己烷二甲醇二丙烯酸酯/丙烯酰胺、丙氧基化新戊二醇二丙烯酸酯/丙烯酰胺、三羟甲基丙烷三丙烯酸酯/丙烯酰胺、三丙烯酸季戊四醇酯/丙烯酰胺、乙氧基化三羟甲基丙烷三丙烯酸酯/丙烯酰胺、丙氧基化三羟甲基丙烷三丙烯酸酯/丙烯酰胺、丙氧基化甘油三丙烯酸酯/丙烯酰胺、二(三羟甲基)丙烷四丙烯酸酯/丙烯酰胺、五丙烯酸二季戊四醇酯/丙烯酰胺、乙氧基化季戊四醇四丙烯酸酯/丙烯酰胺、PEG 200二甲基丙烯酸酯/丙烯酰胺、PEG 400二甲基丙烯酸酯/丙烯酰胺、PEG 600二甲基丙烯酸酯/丙烯酰胺、3-丙烯酰氧基二醇单丙烯酸酯/丙烯酰胺、三丙烯酰基缩甲醛、异氰酸三烯丙酯和异氰脲酸三烯丙酯。
单体通常在升高的温度(例如,30-90℃)或在UV光下在活化剂(例如,引发剂)的存在下聚合。示例性引发剂是2,2’-偶氮双(异丁腈)(“AIBN”)、过氧化二碳酸二鲸蜡酯、过氧化二碳酸二(4-叔丁基环己基)酯、过氧化二辛酰、过氧化二苯甲酰、过氧化二月桂酰、过氧化二癸酰、过乙酸叔丁酯、过月桂酸叔丁酯、过苯甲酸叔丁酯、叔丁基过氧化氢、异丙苯过氧化氢、乙基过氧化异丙苯(cumene ethylperoxide)、二异丙基羟基二甲酸酯、2,2’-偶氮双(2,4-二甲基戊腈)、1,1’-偶氮双(环己烷-1-甲腈)、2,2’-偶氮双(2-甲基丙酸)二甲酯、2,2’-偶氮双[2-甲基-N-(2-羟乙基)丙酰胺、过硫酸钠、过氧化苯甲酰及其组合。
用于形成聚丙烯酸酯/聚丙烯酰胺/聚(丙烯酸酯-共-丙烯酰胺)胶囊壁的乳化剂典型地是阴离子乳化剂,通过举例说明而不是限制,包括以下的水溶性盐:烷基硫酸盐、烷基醚硫酸盐、烷基异硫代硫酸盐(alkyl isothionates)、烷基羧酸盐、烷基磺基琥珀酸盐、烷基琥珀酰胺酸盐(alkyl succinamates)、烷基硫酸盐如十二烷基硫酸钠、烷基肌氨酸盐、蛋白质水解产物的烷基衍生物、酰基天冬氨酸盐、烷基或烷基醚或烷基芳基醚磷酸酯、十二烷基硫酸钠、磷脂或卵磷脂、或皂、硬脂酸钠、硬脂酸钾或硬脂酸铵、油酸盐或棕榈酸盐、烷基芳基磺酸盐如十二烷基苯磺酸钠、二烷基磺基琥珀酸钠、二辛基磺基琥珀酸盐、二月桂基磺基琥珀酸钠、聚(苯乙烯磺酸)钠盐、异丁烯-马来酸酐共聚物、阿拉伯树胶、藻酸钠、羧甲基纤维素、纤维素硫酸盐和果胶、聚(苯乙烯磺酸盐)、异丁烯-马来酸酐共聚物、阿拉伯树胶、角叉菜胶、藻酸钠、果胶酸、黄蓍胶、杏仁胶和琼脂;半合成聚合物如羧甲基纤维素、硫酸化纤维素、硫酸化甲基纤维素、羧甲基淀粉、磷酸化淀粉、木质素磺酸;和合成聚合物如马来酸酐共聚物(包括其水解产物)、聚丙烯酸、聚甲基丙烯酸、丙烯酸-丙烯酸丁酯共聚物或巴豆酸均聚物和共聚物、乙烯基苯磺酸或2-丙烯酰胺基-2-甲基丙磺酸均聚物和共聚物、以及此类聚合物和共聚物的部分酰胺或部分酯、羧基改性的聚乙烯醇、磺酸改性的聚乙烯醇和磷酸改性的聚乙烯醇、磷酸化或硫酸化的三苯乙烯基苯酚乙氧基化物。阴离子乳化剂的量是所有组分的0.1至40重量百分比、更优选0.5至10重量百分比、更优选0.5至5重量百分比中的任何一点。
氨基塑料(Aminoplast)和明胶。用于氨基塑料囊封的代表性工艺披露于US 3,516,941和US 2007/0078071,但是已意识到关于材料和工艺步骤的许多变形是可能的。另一种囊封工艺,即明胶囊封,披露于US 2,800,457。两种工艺分别在用于美国专利号4,145,184和5,112,688的消费品中的香精囊封的情形进行了讨论。聚合物体系在本领域是熟知的并且这些的非限制性实例包括如在GB 2006709 A中披露的氨基塑料胶囊和囊封粒子;如在US 4,396,670中披露的具有壁的微胶囊的生产,所述壁包含与三聚氰胺-甲醛预缩合物反应的苯乙烯-马来酸酐;如在US 5,089,339中披露的与三聚氰胺-甲醛树脂交联的丙烯酸-丙烯酰胺共聚物;如在US 5,401,577中披露的由阳离子三聚氰胺-甲醛缩合物构成的胶囊;如在US 3,074,845中披露的三聚氰胺甲醛微囊封;如在EP 0 158 449 A1中披露的酰胺基-醛树脂原位聚合的胶囊;如在US 5,204,185中披露的醚化的脲-甲醛聚合物;如描述于US4,525,520中的三聚氰胺-甲醛微胶囊;如描述于US 5,011,634中的交联的油溶性三聚氰胺-甲醛预缩合物;如在US 5,013,473中披露的由阳离子和阴离子三聚氰胺-甲醛预缩合物(其随后发生交联)的复合物形成的胶囊壁材料;如在US 3,516,941中披露的由加成聚合物如缩合聚合物、酚醛树脂、脲醛树脂或丙烯酸聚合物制成的聚合物壳;如在EP 0 443 428A2中披露的脲-甲醛胶囊;如在GB 2 062 570 A中披露的三聚氰胺-甲醛化学;以及如在US4,001,140中披露的,由以酸或盐形式的苯乙烯磺酸的聚合物或共聚物构成的胶囊,和与三聚氰胺-甲醛交联的胶囊。
脲-甲醛和三聚氰胺-甲醛胶囊。脲-甲醛和三聚氰胺-甲醛预缩合物胶囊壳壁前体通过使脲或三聚氰胺与甲醛反应来制备,其中三聚氰胺或脲与甲醛的摩尔比在10:1至1:6、优选1:2至1:5的范围内。对于实施本发明的目的,所得的材料具有在156至3000范围内的分子量。所得的材料可以‘按照原样’用作用于前述取代或未取代丙烯酸聚合物或共聚物的交联剂,或者它可以进一步与C1-C6链烷醇,例如,甲醇、乙醇、2-丙醇、3-丙醇、1-丁醇、1-戊醇或1-己醇反应,由此形成部分醚,其中三聚氰胺/脲:甲醛:链烷醇的摩尔比在1:(0.1-6):(0.1-6)的范围内。所得的含醚部分的产物可以‘按照原样’用作用于前述取代或未取代丙烯酸聚合物或共聚物的交联剂,或者它可以自身缩合以形成二聚体、三聚体和/或四聚体,其也可以用作用于前述取代或未取代丙烯酸聚合物或共聚物的交联剂。用于形成这样的三聚氰胺-甲醛和脲-甲醛预缩合物的方法在美国专利号6,261,483以及Lee等(2002)J.Microencapsulation 19,559-569中提出。
可用于实施本发明的脲-甲醛预缩合物的实例是以商标180和186(Cytec Technology Corp.,Wilmington,DE)销售的产品。可用于实施本发明的三聚氰胺-甲醛预缩合物的实例包括,但不限于,由Cytec Technology Corp以商标U-60、/>U-64和/>U-65销售的产品。作为用于交联的预缩合物,优选使用取代或未取代丙烯酸聚合物或共聚物。在实施本发明中,脲-甲醛预缩合物/三聚氰胺-甲醛预缩合物与取代/未取代丙烯酸聚合物/共聚物的摩尔比的范围在9:1至1:9、优选5:1至1:5并且最优选2:1至1:2的范围内。
在本发明的一个实施方案中,也可以使用具有由伯胺和/或仲胺反应性基团或其混合物和交联剂构成的一种或多种聚合物的微胶囊。参见US 2006/0248665。胺聚合物可以具有伯胺和/或仲胺官能度并且可以为天然或合成来源的。天然来源的含胺聚合物典型地是蛋白质如明胶和白蛋白,以及一些多糖。合成胺聚合物包括各种程度的水解聚乙烯甲酰胺、聚乙烯胺、聚烯丙胺和具有伯胺和仲胺侧基的其他合成聚合物。合适的胺聚合物的实例是可从巴斯夫(BASF)获得的以聚乙烯甲酰胺的系列商标销售的产品。这些材料的分子量可以在10,000至1,000,000的范围内。
脲-甲醛或三聚氰胺-甲醛胶囊也可以包含甲醛清除剂,其能够结合游离甲醛。当胶囊用于在含水介质中使用时,甲醛清除剂如亚硫酸钠、三聚氰胺、甘氨酸和碳酰肼(carbohydrazine)是合适的。当胶囊旨在用于具有低pH的产品,例如,织物护理调理剂中时,甲醛清除剂优选选自β二酮,如β-酮酯,或选自1,3-二醇,如丙二醇。优选的β-酮酯包括烷基-丙二酸酯、乙酰乙酸烷基酯和聚乙烯醇乙酰乙酸酯。
本发明的微胶囊组合物任选地含有一个或多个另外的微胶囊,例如,第二、第三、第四、第五或第六微胶囊。这些微胶囊中的每一个可以是如上所述的微胶囊中的任一种。
这些另外的微胶囊可以是如上所述的微胶囊中的任一种,但是在微胶囊尺寸、聚合度、交联度、囊封聚合物、壁厚度、活性材料、壁材料与活性材料之间的比率、破裂力或断裂强度等方面彼此不同。
活性材料
本发明的胶囊的芯可以包含一种或多种活性材料,所述活性材料包括,但不限于,香料和/或香精成分如香精油。可以囊封的个体活性材料包括WO 2016049456第38-50页中列出的那些。这些活性材料包括香料或香精成分、掩味剂、味觉感知剂、恶臭中和剂、维生素或其衍生物、抗菌剂、遮光剂活性成分(sunscreen active)、抗氧化剂、抗炎剂、杀真菌剂、麻醉剂、止痛剂、抗真菌剂、抗生素、抗病毒剂、抗寄生虫剂、抗感染剂、祛痘剂、皮肤活性成分、酶和辅酶、皮肤增白剂、抗组胺剂、化疗剂、驱昆虫剂、软化剂、皮肤保湿剂、皱纹控制剂、UV防护剂、织物柔顺剂活性成分、硬表面清洁活性成分、皮肤或头发调理剂、兽用驱避剂、驱寄生虫剂、阻燃剂、抗静电剂、纳米至微米尺寸的无机固体、聚合物或弹性体颗粒及其组合。
除了以上列出的活性材料之外,本发明的产品还可以含有,例如以下染料、着色剂或颜料:乳黄素(lactoflavin)(核黄素(riboflavin))、β-胡萝卜素、核黄素-5’-磷酸酯、α-胡萝卜素、γ-胡萝卜素、角黄素(cantaxanthin)、赤藓红、姜黄素、喹啉黄、黄橙S、酒石黄、胭脂树素、降胭脂树素(胭脂树红、胭脂树橙(orlean))、辣椒红、辣椒红素、番茄红素、β-阿朴-8’-胡萝卜醛、β-阿朴-8’-胡萝卜素酸乙酯、叶黄素(xantophylls)(黄黄质、黄体素、隐黄质、玉红黄质、紫黄质、紫衫紫素(rodoxanthin))、坚牢洋红(fast carmine)(胭脂红酸、胭脂虫红)、偶氮玉红、胭脂虫红A(Ponceau 4R)、甜菜红、甜菜苷、花青素、苋菜红、专利蓝V、靛蓝I(靛蓝-胭脂红)、叶绿素、叶绿素的铜化合物、酸性亮绿BS(丽丝胺绿)、亮黑BN、植物碳、二氧化钛、铁氧化物和氢氧化物、碳酸钙、铝、银、金、颜料宝红BK(立索尔(lithol)宝红BK)、甲基紫B、维多利亚蓝R、维多利亚蓝B、阿西仑(acilan)亮蓝FFR(亮羊毛蓝FFR)、萘酚绿B、阿西仑坚牢绿10G(碱性坚牢绿10G)、ceres黄GRN、苏丹蓝II、群青、酞菁蓝、酞菁绿、坚牢酸性紫R。另外的天然获得的提取物(例如红辣椒提取物、黑胡萝卜提取物、红甘蓝提取物)可以用于着色目的。还利用以下命名的颜色(所谓的铝色淀)实现好的结果:FD&C黄5色淀、FD&C蓝2色淀、FD&C蓝1色淀、酒石黄色淀、喹啉黄色淀、FD&C黄6色淀、FD&C红40色淀、日落黄色淀、蓝光酸性红色淀、苋菜红色淀、Ponceau 4R色淀、赤藓红色淀、红2G色淀、诱惑红色淀(Allura Red Lake)、专利蓝V色淀、靛蓝胭脂红色淀、亮蓝色淀、棕HT色淀、黑PN色淀、绿S色淀及其混合物。
当活性材料是香精时,优选的是,采用在具有0.5至15的ClogP的香精内的香精成分。例如,按香精的重量计,具有0.5至8(例如,1至12、1.5至8、2至7、1至6、2至6、2至5和3至7)的ClogP值的成分为25%以上(例如,50%以上和90%以上)。
优选的是,采用具有2.5以上(例如,3以上、2.5至7和2.5至5)的重均ClogP的香精。重均ClogP的计算如下:
ClogP={Sum[(Wi)(ClogP)i]}/{Sum Wi},
其中Wi是各香精成分的重量分数,并且(ClogP)i是该香精成分的ClogP。
作为示例,优选的是,大于60重量%(优选大于80重量%并且更优选大于90重量%)的香精化学品具有大于2(优选大于3.3、更优选大于4并且甚至更优选大于4.5)的ClogP值。
本领域技术人员将理解,许多香精可以采用多种溶剂和香精化学品制造。较低至中等ClogP香精成分的使用将导致适合于囊封的香精。这些香精通常是水溶性的,以在不同阶段如潮湿和干燥的织物中通过本发明的胶囊体系被递送到消费品上。在没有囊封的情况下,游离香精通常会蒸发或在使用例如洗涤期间溶解于水。尽管高ClogP材料通常良好地由常规(未囊封)香精递送在消费品中,但是它们具有优异的囊封性质并且也适合于囊封用于总体香精特性目的、非常持久的香精递送或克服与消费品的不相容性,例如否则将不稳定的香精材料造成产品的增稠或脱色,或者以其他方式负面影响所需的消费品性质。
在一些实施方案中,囊封的活性材料的量按微胶囊组合物的重量计为5%至95%(例如,10%至90%、15%至80%和20%至60%)。胶囊壁的量同样按微胶囊组合物的重量计为0.5%至30%(例如,1%至25%、2%至20%和5%至15%)。在其他实施方案中,囊封的活性材料的量按微胶囊的重量计为15%至99.5%(例如,20%至98%和30%至90%),并且胶囊壁的量按微胶囊的重量计为0.5%至85%(例如,2%至50%和5%至40%)。
辅助材料
除了活性材料之外,本发明还考虑了在由胶囊壁囊封的芯中掺入辅助材料,包括溶剂、软化剂和芯改性剂材料。其他辅助材料是溶解度调节剂、密度调节剂、稳定剂、粘度调节剂、pH调节剂或其任意组合。这些调节剂可以在胶囊的壁或芯中存在或者在递送系统中的胶囊外部存在。优选地,它们作为芯改性剂在芯中。
一种或多种辅助材料可以以按微胶囊的重量计0.01%至40%(例如,0.5%至30%)的量添加。
合适的实例包括在WO 2016/049456第55-57页和US 2016/0158121第15-18页中描述的那些。
沉积助剂
可用于本发明的微胶囊组合物的示例性沉积助剂是丙烯酰胺和丙烯酰胺基丙基三甲基氯化铵的共聚物。该共聚物促进微胶囊在硬表面(例如,毛发、皮肤、纤维、家具和地板)上的沉积。共聚物通常具有2,000道尔顿至10,000,000道尔顿的平均分子量(例如,通过尺寸排阻色谱测定的重均分子质量(Mw)),其中下限为2,000、5,000、10,000、20,000、50,000、100,000、250,000、500,000或800,000道尔顿并且上限为10,000,000、5,000,000、2,000,000、1,000,000或500,000道尔顿(例如,500,000至2,000,000和800,000至1,500,000道尔顿)。共聚物的电荷密度在1meq/g至2.5meq/g、优选1.5至2.2meq/g的范围内。丙烯酰胺和丙烯酰胺基丙基三甲基氯化铵的共聚物可从多个供应商商购获得,诸如从Ashland以商标SP-100和Ciba/>SC60商购获得。
其他合适的沉积助剂包括阴离子、阳离子、非离子或两性水溶性聚合物。合适的沉积助剂包括:聚季铵盐-4、聚季铵盐-5、聚季铵盐-6、聚季铵盐-7、聚季铵盐-10、聚季铵盐-16、聚季铵盐-22、聚季铵盐-24、聚季铵盐-28、聚季铵盐-39、聚季铵盐-44、聚季铵盐-46、聚季铵盐-47、聚季铵盐-53、聚季铵盐-55、聚季铵盐-67、聚季铵盐-68、聚季铵盐-69、聚季铵盐-73、聚季铵盐-74、聚季铵盐-77、聚季铵盐-78、聚季铵盐-79、聚季铵盐-80、聚季铵盐-81、聚季铵盐-82、聚季铵盐-86、聚季铵盐-88、聚季铵盐-101、聚乙烯胺、聚乙烯亚胺、聚乙烯胺和乙烯甲酰胺(vinylformamide)共聚物、甲基丙烯酰胺基丙基-三甲基氯化铵/丙烯酰胺共聚物及其组合。WO 2016049456第13-27页;和US 2014/0017278中描述了沉积助剂的更多实例。
另外的沉积助剂是WO2016032993中描述的那些阳离子聚合物。典型地,这些阳离子聚合物的特征在于相对较高的电荷密度(例如,从4meq/g、或从5meq/g、或从5.2meq/g,到12meq/g、或到10meq/g、或到8meq/g、或到7meq/g、或到6.5meq/g)。阳离子聚合物由非离子、阳离子、阴离子的结构单元或其混合物构成。在一些方面,阳离子聚合物包含5摩尔%至60摩尔%或15摩尔%至30摩尔%的非离子结构单元,所述结构单元衍生自选自由以下组成的组的单体:(甲基)丙烯酰胺、乙烯甲酰胺、N,N-二烷基丙烯酰胺、N,N-二烷基甲基丙烯酰胺、丙烯酸C1-C12烷基酯、丙烯酸C1-C12羟基烷基酯、聚亚烷基二醇丙烯酸酯、甲基丙烯酸C1-C12烷基酯、甲基丙烯酸C1-C12羟基烷基酯、聚亚烷基二醇甲基丙烯酸酯、乙酸乙烯酯、乙烯醇、乙烯甲酰胺、乙烯乙酰胺、乙烯基烷基醚、乙烯基吡啶、乙烯吡咯烷酮、乙烯基咪唑、乙烯基己内酰胺及其混合物。
在一些方面,阳离子聚合物以按阳离子聚合物的质量计30摩尔%至100摩尔%、或50摩尔%至100摩尔%、或55摩尔%至95摩尔%、或70摩尔%至85摩尔%的水平包含阳离子结构单元。典型地,阳离子结构单元衍生自阳离子单体,诸如甲基丙烯酸N,N-二烷基氨基烷基酯、丙烯酸N,N-二烷基氨基烷基酯、N,N-二烷基氨基烷基丙烯酰胺、N,N-二烷基氨基烷基甲基丙烯酰胺、甲基丙烯酰胺基烷基三烷基铵盐、丙烯酰胺基烷基三烷基铵盐、乙烯胺、乙烯基亚胺、乙烯基咪唑、季铵化的乙烯基咪唑、二烯丙基二烷基铵盐及其混合物。优选地,阳离子单体选自由以下组成的组:二烯丙基二甲基铵盐(DADMAS)、丙烯酸N,N-二甲基氨基乙酯、甲基丙烯酸N,N-二甲基氨基乙酯(DMAM)、[2-(甲基丙烯酰胺基)乙基]三甲基铵盐、N,N-二甲基氨基丙基丙烯酰胺(DMAPA)、N,N-二甲基氨基丙基甲基丙烯酰胺(DMAPMA)、丙烯酰胺基丙基三甲基铵盐(APTAS)、甲基丙烯酰胺基丙基三甲基铵盐(MAPTAS)、季铵化的乙烯基咪唑(QVi)及其混合物。
在一些方面,阳离子聚合物以按阳离子聚合物的质量计0.01摩尔%至15摩尔%、0.05摩尔%至10摩尔%、0.1摩尔%至5摩尔%或1%至4%的水平包含阴离子结构单元。在一些方面,阴离子结构单元衍生自阴离子单体,所述阴离子单体选自由以下组成的组:丙烯酸(AA)、甲基丙烯酸、马来酸、乙烯基磺酸、苯乙烯磺酸、丙烯酰胺基丙基甲磺酸(AMPS)及其盐,以及它们的混合物。
示例性的阳离子聚合物包括聚丙烯酰胺-共-DADMAS、聚丙烯酰胺-共-DADMAS-共-丙烯酸、聚丙烯酰胺-共-APTAS、聚丙烯酰胺-共-MAPTAS、聚丙烯酰胺-共-QVi、聚乙烯甲酰胺-共-DADMAS、聚(DADMAS)、聚丙烯酰胺-共-MAPTAS-共丙烯酸、聚丙烯酰胺-共-APTAS-共-丙烯酸及其混合物。
沉积助剂通常以按微胶囊组合物的重量计0.01%至50%(其中下限为0.01%、0.05%、0.1%、0.5%、1%、2%或5%并且上限为50%、40%、30%、20%、15%或10%,例如0.1%至30%、1%至20%、2%至15%和5%至10%)的水平存在。在诸如洗发剂的消费品中,沉积助剂通常以按洗发剂组合物的重量计0.001%至20%(其中下限为0.001%、0.005%、0.01%、0.02%或0.05%并且上限为20%、15%、10%、5%、2%或1%,例如0.005%至10%、0.01%至5%和0.02%至0.5%)的水平存在。胶囊沉积助剂可以在微胶囊的制备期间添加或者其可以在已经制备微胶囊之后添加。
可以将0.01%至25%(更优选5%至20%)的第二胶囊沉积助剂添加到微胶囊组合物中。第二胶囊形成沉积助剂可以选自上述沉积助剂。
另外的组分
本发明的微胶囊组合物可以包含0.01至50%(更优选5至40%)的一种或多种无约束的或未囊封的活性材料。
胶囊递送系统也可以含有一种或多种其他递送系统如聚合物辅助递送组合物(参见US 8,187,580)、纤维辅助递送组合物(US 2010/0305021)、环糊精主客体复合物(US 6,287,603和US 2002/0019369)、前香精(WO 2000/072816和EP 0 922 084),及其任意组合。可以结合的更多示例性递送系统是凝聚胶囊、环糊精递送系统和前香料(pro-perfumes)。
另外的组分的实例包括US 2016/0158121中描述的那些。
以上讨论的任何化合物、聚合物或试剂可以是如上所示的化合物、聚合物或试剂本身,或者其盐、前体、水合物或溶剂化物。盐可以在阴离子和化合物、聚合物或试剂上的带正电荷的基团之间形成。合适的阴离子包括氯离子、溴离子、碘离子、硫酸根、硝酸根、磷酸根、柠檬酸根、甲磺酸根、三氟乙酸根、乙酸根、苹果酸根、甲苯磺酸根、酒石酸根、富马酸根、谷氨酸根、葡糖醛酸根、乳酸根、戊二酸根和马来酸根。同样地,盐也可以在阳离子和化合物、聚合物或试剂上的带负电荷的基团之间形成。合适的阳离子包括钠离子、钾离子、镁离子、钙离子和铵阳离子(例如,四甲基铵离子)。前体可以是酯和另外的合适衍生物,其在制备本发明的聚脲或聚氨酯胶囊组合物的过程期间能够转化为所述化合物、聚合物或试剂并且用于制备聚脲或聚氨酯胶囊组合物。水合物是指含有水的化合物、聚合物或试剂。溶剂化物是指在化合物、聚合物或试剂和合适溶剂之间形成的复合物。合适的溶剂可以是水、乙醇、异丙醇、乙酸乙酯、乙酸和乙醇胺。
某些化合物、聚合物和试剂具有一个或多个立体中心,其每一个可以为R构型、S构型或混合物。此外,一些化合物、聚合物和试剂具有一个或多个双键,其中各个双键以E(反式)或Z(顺式)构型或其组合存在。所述化合物、聚合物和试剂包括所有可能的构型立体异构体、区域异构体(regioisomeric)、非对映异构体、对映异构体和差向异构体形式以及其任意混合物。因此,本文中使用的赖氨酸包括L-赖氨酸、D-赖氨酸、L-赖氨酸单盐酸盐、D-赖氨酸单盐酸盐、赖氨酸碳酸盐等。类似地,精氨酸包括L-精氨酸、D-精氨酸、L-精氨酸单盐酸盐、D-精氨酸单盐酸盐、精氨酸碳酸盐、精氨酸一水合物等。胍包括胍盐酸盐、胍碳酸盐、胍硫氰酸盐、以及其他胍盐,包括其水合物。鸟氨酸包括L-鸟氨酸及其盐/水合物(例如,单盐酸盐)和D-鸟氨酸及其盐/水合物(例如,单盐酸盐)。
本发明的微胶囊组合物可以是在溶剂(例如,水)中以按胶囊递送系统的重量计0.1至80%(优选1至65%并且更优选5至45%)的水平含有胶囊的浆料。示例性的本发明的微胶囊组合物含有各自分散在水相中的多个微胶囊,并且在40℃的温度下稳定达至少7天(例如,至少10天、至少30天和至少60天)。通过澄清水相从微胶囊组合物中的分离来测量稳定性(例如,在量筒中)。如果分离出按微胶囊组合物的体积计少于10%的澄清水相,则认为微胶囊组合物是稳定的。当(i)组合物的粘度为3000cP以下(例如,2000cP以下)并且(ii)按组合物的体积计20%以下(例如,15%以下和10%以下)的水从组合物中分离时,则认为微胶囊组合物是稳定的。分离的水的体积可以通过常规方法(例如,量筒)容易地测量。
已知微胶囊组合物倾向于形成凝胶,从而不适合用于许多消费品中。胶凝出的组合物的粘度增加到至少3000厘泊(cP)(例如,至少6000cP)。粘度可以在流变仪(例如RheoStressTM 1仪器(可从ThermoScientific商购获得))上容易地测量(使用转盘,剪切速率为21s-1并且温度为25℃)。
在一些实施方案中,通过用水洗涤胶囊浆料直至达到中性pH(pH 6至8)来纯化微胶囊组合物。对于本发明的目的,胶囊悬浮液可以使用任何常规方法(包括使用分液漏斗、滤纸、离心等)洗涤。胶囊悬浮液可以洗涤一次、两次、三次、四次、五次、六次或更多次直至达到中性pH,例如,pH 6-8和6.5-7.5。经纯化的胶囊的pH可以使用任何常规方法(包括但不限于pH纸、pH指示剂或pH计)确定。
胶囊组合物被“纯化”以使其与胶囊是80%、90%、95%、97%、98%或99%均质的。根据本发明,通过洗涤胶囊直至达到中性pH而实现纯度(purity),其是去除不需要的杂质和/或起始材料(例如,多异氰酸酯、交联剂等)的指示。
在本发明的某些实施方案中,胶囊的纯化包括在用水洗涤胶囊悬浮液的步骤之前向胶囊悬浮液中添加盐的额外步骤。在本发明的此步骤中使用的示例性盐包括,但不限于,氯化钠、氯化钾或亚硫酸氢盐。参见US 2014/0017287。
还可以将本发明的微胶囊组合物干燥(例如,喷雾干燥、加热干燥和带式干燥)成固体形式。在喷雾干燥过程中,将喷雾干燥载体添加至微胶囊组合物以有助于从浆料中除去水。参见US20120151790、US20140377446、US20150267964、US20150284189和US20160097591。
根据一个实施方案,喷雾干燥载体可以选自由以下组成的组:碳水化合物如化学改性淀粉和/或水解淀粉,树胶如阿拉伯树胶,蛋白质如乳清蛋白,纤维素衍生物,粘土,合成的水溶性聚合物和/或共聚物如聚乙烯吡咯烷酮、聚乙烯醇。喷雾干燥载体可以以按浆料中微胶囊组合物的重量计1%至50%(更优选5%至20%)的量存在。
任选地,二氧化硅的自由流动剂(抗结块剂),其可以是疏水性的(即用卤硅烷、烷氧基硅烷、硅氮烷、硅氧烷等表面处理的硅醇,如可从Degussa,Piscataway,New Jersey以商标D17、/>R972和R974获得的商业产品)和/或亲水性的可以商标200、/>22S、/>50S(可从Degussa获得)、/>244(可从Grace Davison获得)获得,可以以按浆料中微胶囊组合物的重量计0.01%至10%(更优选0.5%至5%)存在。
也可以添加润湿剂和粘度控制剂/悬浮剂以促进喷雾干燥。在美国专利号4,446,032和6,930,078中公开了这些试剂。美国专利号5,500,223和6,608,017中公开了作为不同于自由流动剂/抗结块剂的活性材料的功能性递送媒介物的疏水性二氧化硅的细节。
喷雾干燥入口温度在150℃至240℃、优选170℃至230℃、更优选190℃至220℃的范围内。
如本文中所述,经喷雾干燥的微胶囊组合物良好地适合用于各种各样的所有干燥(无水)产品:粉末衣物洗涤剂,织物柔顺剂烘干纸,家用清洁干巾,粉末碗碟洗涤剂,地板清洁布或任何干燥形式的个人护理产品(例如,洗发粉,祛臭粉,足粉,肥皂粉,婴儿爽身粉)等。由于本发明的喷雾干燥产品中的高香精和/或活性剂浓度,前述消费品干燥产品的特性将不受小剂量的喷雾干燥产品的不利影响。
微胶囊组合物还可以作为浆料喷洒到消费品例如织物护理产品上。作为示例,在共混期间将含有胶囊的液体递送系统喷洒到洗衣粉上以制备颗粒。参见US 2011/0190191。为了增加香精负载,可以将吸水性材料如沸石添加至递送系统。
备选地,消费品中的颗粒在造粒助剂如非酸水溶性有机结晶固体存在下在机械造粒机中制备。参见WO 2005/097962。
ζ电位和破裂力
本发明的微胶囊是带正电荷的,如至少10mV、优选至少25mV(例如,25mV至200mV)并且更优选至少40mV(例如,40mV至100mV)的ζ电位所指示的。
ζ电位是微胶囊中的电动电位的量度。从理论的角度来看,ζ电位是水相(即,分散介质)和附着至微胶囊表面的水的稳定层之间的电位差。
ζ电位是组合物或消费品中的微胶囊稳定性的关键指示。典型地,具有10mV至25mV的ζ电位的微胶囊显示出适中的稳定性。类似地,具有25mV至40mV的ζ电位的微胶囊显示出良好的稳定性并且具有40mV至100mV的ζ电位的微胶囊显示出优异的稳定性。不受任何理论限制,本发明的微胶囊具有所需的ζ电位,使其适合于在具有改善的稳定性的情况下在消费品中使用。
可以使用理论模型和实验确定的电泳迁移率或动态电泳迁移率来计算ζ电位。通常通过诸如显微电泳或电泳光散射或电声现象的方法来测量ζ电位。对于更详细的测量ζ电位的讨论,参见Dukhin和Goetz,“Ultrasound for characterizing colloids”,Elsevier,2002。
本发明的微胶囊具有0.2MPa至80MPa(例如,0.5MPa至60MPa、1MPa至50MPa和5MPa至30MPa)的断裂强度。各个微胶囊的断裂强度通过将破裂力(以牛顿计)除以相应微胶囊的横截面积(πr2,其中r是压缩前粒子的半径)来计算。破裂力和横截面积的测定按照Zhang等,J.Microencapsulation 18(5),593-602(2001)中描述的方法进行。
本发明的微胶囊具有小于10毫牛顿(“mN”)的破裂力,诸如0.1mN至10mN、0.2mN至8mN、0.3mN至5mN、0.1mN至2mN、0.1mN、0.5mN、1mN、2mN、5mN和8mN。破裂力是使微胶囊破裂所需要的力。其测定基于本领域中作为显微操控已知的技术。参见Zhang等,Journal ofMicroencapsulation 16(1),117-124(1999)。
头发护理产品
本发明的微胶囊适合于在头发护理产品(包括洗发剂组合物)和头发调理产品中使用。
洗发剂组合物通常含有去污组合物、载体、微胶囊和沉积助剂。去污组合物可以全部是水相,或者可以包含油相和水相二者,并且可以包含以下组分的任何组合:去污表面活性剂、抗头屑剂和水性载体。去污表面活性剂为组合物提供清洁性能。去污表面活性剂进而包含阴离去污表面活性剂、两性离子或两性去污表面活性剂或其组合。去污表面活性剂的各种实例和描述在美国专利公开20160228338(其通过引用整体结合于此)中说明。
洗发剂中阴离子表面活性剂组分的浓度应足以提供所需的清洁和起泡性能,并且通常在按洗发剂组合物的重量计2%至50%(例如,8%至30%、10%至25%和12%至22%)的范围内。
适合在组合物中使用的阴离子表面活性剂是烷基硫酸盐和烷基醚硫酸盐。其他合适的阴离子去污表面活性剂是有机硫酸反应产物的水溶性盐。另外的其他合适的阴离子去污表面活性剂是被羟基乙磺酸酯化并且被氢氧化钠中和的脂肪酸的反应产物。实例包括月桂基硫酸铵、月桂基聚醚硫酸铵、月桂基硫酸三乙胺、月桂基聚醚硫酸三乙胺、月桂基硫酸三乙醇胺、月桂基聚醚硫酸三乙醇胺、月桂基硫酸单乙醇胺、月桂基聚醚硫酸单乙醇胺、月桂基硫酸二乙醇胺、月桂基聚醚硫酸二乙醇胺、月桂酸甘油单酯硫酸钠、月桂基硫酸钠、月桂基聚醚硫酸钠、月桂基硫酸钾、月桂基聚醚硫酸钾、月桂基肌氨酸钠、月桂酰肌氨酸钠、月桂基肌氨酸、椰油酰肌氨酸、椰油酰硫酸铵、月桂酰硫酸铵、椰油酰硫酸钠、月桂酰硫酸钠、椰油酰硫酸钾、月桂基硫酸钾、月桂基硫酸三乙醇胺、月桂基硫酸三乙醇胺、椰油酰硫酸单乙醇胺、月桂基硫酸单乙醇胺、十三烷基苯磺酸钠、十二烷基苯磺酸钠、椰油酰羟乙基磺酸钠及其组合。在本发明的另一个实施方案中,阴离子表面活性剂是月桂基硫酸钠或月桂基聚醚硫酸钠。
合适的两性或两性离子去污表面活性剂包括已知用于头发护理或其他个人护理清洁的那些。这样的两性去污表面活性剂的浓度在0.5%至20%(例如,1%至10%)的范围内。合适的两性离子或两性表面活性剂的非限制性实例在美国专利号5,104,646(BolichJr.等)、5,106,609(Bolich Jr.等)中描述。两性去污表面活性剂的实例包括椰油基两性乙酸盐、椰油基两性二乙酸盐、月桂基两性乙酸盐、月桂基两性二乙酸盐及其混合物。适合在组合物中使用的两性离子去污表面活性剂包括广泛描述为脂族季铵、鏻和锍化合物的衍生物的那些表面活性剂,其中脂族基团可以是直链或支链,并且其中脂族取代基中的一个含有约8至约18个碳原子并且一个含有阴离子基团(诸如羧基、磺酸根、硫酸根、磷酸根或膦酸根)。在另一个实施方案中,选择诸如甜菜碱的两性离子表面活性剂。适合在组合物中使用的其他阴离子表面活性剂、两性离子表面活性剂、两性表面活性剂或任选的另外的表面活性剂的非限制性实例在McCutcheon’s,Emulsifiers and Detergents,1989年刊(M.C.Publishing Co.出版)和美国专利号3,929,678中描述。
去污组合物还可以含有抗头屑剂。实例包括抗微生物活性成分、吡啶硫酮盐、唑类、硫化硒、硫颗粒、角质层分离酸、水杨酸、羟甲辛吡酮(octopirox)(吡罗克酮乙醇胺(piroctone olamine))、煤焦油及其组合。在一个方面,抗头屑剂通常是吡啶硫酮盐。这样的抗头屑剂应在物理上和在化学上与组合物的必需组分相容,并且不应以其他方式不当地损害产品稳定性、美容性或性能。
洗发剂组合物可以是(在环境条件下)可倾倒的液体的形式。因此,这样的组合物通常将包含水性载体,其以20%至95%(例如,60%至85%)的水平存在。水性载体可以包括水,或者水和有机溶剂的可混溶混合物,并且在一个方面可以包括水与最低或非显著浓度的有机溶剂,除了另外作为其他必需或任选组分的次要成分偶然地掺入组合物中以外。可用于本发明的载体包括水以及低级烷基醇和多元醇的水溶液。本文中可用的低级烷基醇是具有1至6个碳的一元醇,在一个方面其是乙醇和异丙醇。本文中可用的多元醇包括丙二醇、己二醇、甘油和丙烷二醇。
洗发剂组合物还可以包含已知在组合物中使用或以其他方式可用于组合物的其他任选成分。最典型地,这样的任选成分是在参考书中描述的那些,诸如CTFA化妆品成分手册(the CTFA Cosmetic Ingredient Handbook),第二版,The Cosmetic,Toiletries,andFragrance Association,Inc.1988,1992。这样的任选成分的非限制性实例包括香料或香精、着色剂或染料、头发漂白剂、增稠剂、保湿剂、软化剂、药物活性成分、维生素或营养素、抗头屑剂、香料、头发着色剂、头发烫发剂、头发生长剂或恢复剂以及其他类似材料。
洗发剂组合物可以是冲洗型(rinse-off)产品或免洗型(leave-on)产品的形式,并且可以配制为多种产品形式,包括但不限于乳膏、凝胶、乳液、摩丝(mousses)和喷雾剂。
在一个实施方案中,洗发剂组合物是包含少于45%的水的凝胶形式。在这样的实施方案中,凝胶可以具有1,000cP至10,000cP的净粘度。凝胶的净粘度可以定义为剪切速率为1/秒时流体的粘度。从科学上讲,粘度是剪切应力与剪切速率之比。在一些实施方案中,凝胶的剪切速率的范围为0.01/秒至10/秒。粘度可以在流变仪(例如可从ThermoScientific以商标HAAKETM RheoStressTM 1商购获得的仪器)上容易地测量。通常使用转盘以1/秒的剪切速率和25℃的温度获得粘度。
护发剂产品包括护发剂、免洗型(leave-on)护发剂、保留型调理剂(leave-inconditioner)、修护调理剂(rejuvenating conditioner)、膏状漂洗剂(creme rinse)、无油护发剂、冲洗型(rinse-off)护发剂、调理漂洗剂(conditioning rinse)、发泡调理剂、调理造型凝胶、调理摩丝、喷雾式(spay-on)调理剂、美发膏(hair dressing creme)和头发修复喷雾剂。
术语“免洗型(leave-on)”是指施用于身体(包括头发和皮肤)并且不进一步进行清洗步骤的个人护理组合物。与术语“免洗型”相对照,术语“洗去型(rinse-out)”在本文中用于意指在施用产品之后或期间组合物最终从身体诸如皮肤和头发冲洗或清洗的情况下使用的组合物。
调理剂包括用于向头发提供特定调理益处的任何材料。合适的调理剂是给出与光亮、柔软、梳理能力、抗静电性质、湿处理(wet-handling)、损伤、可管理性、浓密(body)和油脂性有关的一种或多种益处的那些。实例包括有机硅(例如,硅油、阳离子有机硅、有机硅树胶、高折射有机硅、有机硅季铵化合物和有机硅树脂)、有机调理油(例如,烃油、聚烯烃、脂肪酸、脂肪醇和脂肪酯)、烷基季铵盐及其组合。参见US 6,696,053和WO 2017/127494。
护发剂产品中的调理剂的浓度应足以提供所需的调理益处,并且对本领域普通技术人员将是明显的(例如,0.1%至30%、0.1%至20%、0.1%至10%和0.1%至6%)。
微胶囊组合物可以以按护发剂组合物的重量计0.02%至15%(例如,0.05%至10%、0.1%至5%和0.5%至3%)的水平存在,或者在香精负载方面以0.01%至5%(例如,0.02%至3%、0.05%至2%和0.1%至1%)的水平存在。术语“香精负载”是指按消费品的重量计的香精的百分比。
头发护理产品可以含有上述微胶囊中的任一种以及调理剂。可以包含在头发护理产品中的任选的另外组分是阳离子增稠剂、载体、软化剂、保湿剂、头发平滑剂、抗氧化剂/游离基清除剂、螯合剂或络合剂、抗炎剂、抗微生物活性成分、遮光剂活性成分、抗头屑剂、造型剂、头发浓密和增容剂、及其组合。参见US 6,696,053和WO 2017/127494。
织物调理产品
本发明的微胶囊组合物还适合于在织物护理产品如织物调理产品中使用。
具有微胶囊组合物的织物调理组合物含有至少一种织物调理剂,优选地浓度为1%至30%(例如,4%至20%、4%至10%和8%至15%)。确定织物调理剂的浓度同时保持其调理益处并且还维持合理的稳定性和保存期限对本领域技术人员将是明显的。
合适的织物调理剂包括阳离子表面活性剂。非限制性实例是季铵化合物诸如烷基化季铵化合物、环或环状季铵化合物、芳族季铵化合物、二季铵化合物、烷氧基化季铵化合物、酰氨基胺(amidoamine)季铵化合物、酯季铵化合物及其混合物。织物柔顺组合物及其组分总体地描述于US 2004/0204337和US 2003/0060390中。合适的柔软剂包括酯季铵盐(esterquats),诸如由Evonik Industries以商标WE 18销售的产品和由Stepan Company以商标/>SP-90销售的产品。
微胶囊组合物可以以0.02%至15%(例如,0.05%至10%、0.1%至5%和0.5%至3%)的水平存在,使得织物调理组合物具有0.01%至5%(例如,0.02%至3%、0.05%至2%和0.1%至1%)的香精负载。
应用。
本发明的微胶囊良好地适合于但不限于在以下另外的产品中使用:
a)家居产品
i.可以利用本发明的液体或粉末衣物洗涤剂包括在美国专利号5,929,022、5,916,862、5,731,278、5,565,145、5,470,507、5,466,802、5,460,752、5,458,810、5,458,809、5,288,431、5,194,639、4,968,451、4,597,898、4,561,998、4,550,862、4,537,707、4,537,706、4,515,705、4,446,042和4,318,818中描述的那些体系。
ii.单位剂量小袋、片剂和胶囊,如在EP 1 431 382 A1、US 2013/0219996 A1、US2013/0284637 A1和US 6,492,315中描述的那些。这些单位剂量制剂可以含有高浓度的功能材料(例如,5-100%织物柔软剂或洗涤剂活性成分)、香精(例如,0.5-100%、0.5-40%和0.5-15%)和香料(例如,0.1-100%、0.1-40%和1-20%)。它们可以不含有水以将水含量限制为低至小于30%(例如,小于20%,小于10%和小于5%)。
iii.增味剂(Scent Booster),如在US 7,867,968、US 7,871,976、US 8,333,289、US 2007/0269651 A1和US2014/0107010 A1中描述的那些。
iv.织物护理产品如漂洗调理剂(含有1至30重量%的织物调理活性成分),织物液体调理剂(含有1至30重量%的织物调理活性成分),滚筒式烘干纸(Tumble Drier Sheet),织物清新剂,织物清新剂喷雾剂,熨烫水和织物柔顺剂系统,如在美国专利号6,335,315、5,674,832、5,759,990、5,877,145、5,574,179、5,562,849、5,545,350、5,545,340、5,411,671、5,403,499、5,288,417和4,767,547中描述的那些。
液体织物柔顺剂/清新剂含有至少一种织物柔软剂,优选地存在浓度为1至30%(例如,4至20%,4至10%和8至15%)。活性材料和织物柔软剂之间的比率可以为1:500至1:2(例如,1:250至1:4和1:100至1:8)。作为示例,当织物柔软剂按织物柔顺剂的重量计为5%时,活性材料为0.01%至2.5%、优选0.02%至1.25%并且更优选0.1%至0.63%。作为另一个实例,当织物柔软剂按织物柔顺剂的重量计为20%时,活性材料为0.04%至10%,优选0.08%至5%并且更优选0.4%至2.5%。活性材料是香精、恶臭中和剂或其混合物。液体织物柔顺剂可以具有0.15%至15%的胶囊(例如,0.5%至10%、0.7%至5%和1%至3%)。当以这些水平包括胶囊时,柔顺剂中的净油当量(NOE)为0.05%至5%(例如,0.15%至3.2%、0.25%至2%和0.3%至1%)。
合适的织物柔软剂包括阳离子表面活性剂。非限制性实例是季铵化合物诸如烷基化季铵化合物、环或环状季铵化合物、芳族季铵化合物、二季铵化合物、烷氧基化季铵化合物、酰氨基胺(amidoamine)季铵化合物、酯季铵化合物及其混合物。织物柔顺组合物及其组分总体地描述于US 2004/0204337和US 2003/0060390中。合适的柔软剂包括酯季铵盐(esterquats),如可从Evonik Industries商购获得的Rewoquat WE 18和可从StepanCompany商购获得的Stepantex SP-90。
v.液体碗碟洗涤剂,如在美国专利号6,069,122和5,990,065中描述的那些。
vi.自动碗碟洗涤剂,如在美国专利号6,020,294、6,017,871、5,968,881、5,962,386、5,939,373、5,914,307、5,902,781、5,705,464、5,703,034、5,703,030、5,679,630、5,597,936、5,581,005、5,169,552和4,714,562中描述的那些。
vii.通用清洁剂,包括桶装可稀释清洁剂和卫生间清洁剂
viii.浴厕清洁剂
ix.浴巾(Bath Tissue)
x.地毯除臭剂
xi.蜡烛
xii.房间除臭剂
xiii.地板清洁剂
xiv.消毒剂
xv.窗户清洁剂
xvi.垃圾袋/垃圾桶内衬
xvii.空气清新剂,包括房间除臭剂和车辆除臭剂、香薰蜡烛、喷雾剂、香油空气清新剂、自动喷雾空气清新剂和中和凝胶珠
xviii.水分吸收剂
xix.家用装置如纸巾和一次性擦拭巾
xx.蛾丸/诱捕剂/饼(Moth balls/traps/cakes)
b)婴儿护理产品
i.尿布疹乳膏/护臀膏
ii.婴儿爽身粉
c)婴儿护理装置
i.尿不湿
ii.围嘴
iii.擦拭巾
d)口腔护理产品。牙齿护理产品(作为用于口腔护理的根据本发明的制备物的实例)通常包括磨料体系(磨料或抛光剂),例如硅酸、碳酸钙、磷酸钙、铝氧化物和/或羟磷石灰,表面活性物质,例如月桂基硫酸钠、月桂基肌氨酸钠和/或椰油酰胺基丙基甜菜碱,润湿剂,例如甘油和/或山梨糖醇,增稠剂,例如羧甲基纤维素、聚乙二醇、角叉菜胶和/或甜味剂,例如糖精,用于令人不愉快的味道感觉的味觉矫正剂,用于另外的通常不是令人不愉快的味道感觉的味觉矫正剂,味觉调节物质(例如肌醇磷酸酯,核苷酸如单磷酸鸟苷、单磷酸腺苷,或者其他物质如谷氨酸钠或2-苯氧丙酸),凉爽活性成分,例如薄荷醇衍生物(例如L-乳酸薄荷酯、L-薄荷基烷基碳酸酯、薄荷酮缩酮、薄荷烷羧酸酰胺)、2,2,2-三烷基乙酸酰胺(例如2,2-二异丙基丙酸甲基酰胺)、icilin和icilin衍生物,稳定剂和活性成分,例如氟化钠、单氟磷酸钠、二氟化锡、季铵氟化物、柠檬酸锌、硫酸锌、焦磷酸锡、二氯化锡、多种焦磷酸盐的混合物、三氯生、鲸蜡基吡啶鎓盐氯化物、乳酸铝、柠檬酸钾、硝酸钾、氯化钾、氯化锶、过氧化氢、调味品和/或碳酸氢钠或味觉矫正剂。
i.牙膏。一种示例性制剂如下:
1.磷酸钙40-55%
2.羧甲基纤维素0.8-1.2%
3.月桂基硫酸钠1.5-2.5%
4.甘油20-30%
5.糖精0.1-0.3%
6.香料油1-2.5%
7.水,足量至100%
一种用于制备该制剂的典型方法包括以下步骤:(i)通过共混机混合根据前述的制剂以提供牙膏,和(ii)添加本发明的组合物并且将所得混合物共混直至均匀。
ii.牙粉
iii.漱口水
iv.牙齿增白剂
v.义齿粘附剂
e)保健设备
i.牙线
ii.牙刷
iii.呼吸器
iv.香薰/调味避孕套
f)妇女卫生保健品如卫生棉塞、卫生巾和擦拭巾,以及护垫
g)个人护理产品:美容或药物制剂,例如,“油包水”(W/O)型乳液,“水包油”(O/W)型乳液或作为例如水包油包水(W/O/W)型的多相乳液,作为PIT乳液、皮克林乳液(Pickering emulsion)、微乳液或纳米乳液;并且特别优选的乳液是“水包油”(O/W)型或水包油包水(W/O/W)型。更具体地,
i.个人清洁剂(条皂,沐浴液和沐浴露)
ii.沐浴调理剂(In-shower conditioner)
iii.防晒和纹身护色(Sunscreen ant tattoo color protection)(喷雾剂、乳液和棒(sticks))
iv.驱昆虫剂
v.洗手液
vi.抗炎香油、软膏和喷雾剂
vii.抗菌软膏和乳膏
viii.感知剂(Sensates)
ix.除臭剂和止汗剂,包括气溶胶和泵喷止汗剂,棒式止汗剂(stickantiperspirant),滚抹式止汗剂、乳液喷雾止汗剂、透明乳液棒式止汗剂、软固体止汗剂、乳液滚抹式止汗剂、透明乳液棒式止汗剂、不透明乳液棒式止汗剂、透明凝胶止汗剂、透明棒式除臭剂、凝胶除臭剂、喷雾除臭剂、滚抹式和乳膏除臭剂。
x.基于蜡的除臭剂。一种示例性制剂如下:
1.石蜡(Parafin Wax)10-20%
2.烃蜡5-10%
3.白矿脂10-15%
4.乙酰化的羊毛脂醇2-4%
5.己二酸二异丙酯4-8%
6.矿物油40-60%
7.防腐剂(根据需要)
该制剂通过以下制备:(i)混合上述成分,(ii)将得到的组合物加热至75℃直至熔化,(iii)在搅拌下,添加4%低温研磨的包含香精的聚合物同时保持温度为75℃,和(iv)搅拌得到的混合物以确保均匀的悬浮液同时将本发明的组合物添加至制剂。
xi.二醇/皂型除臭剂。一种示例性制剂如下:
1.丙二醇60-70%
2.硬脂酸钠5-10%
3.蒸馏水20-30%
4.2,4,4-三氯-2’-羟基二苯基醚,由Ciba-Geigy Chemical Company制造,并且商标是Ciba-Geigy Chemical Company)0.01-0.5%
将各成分合并,并在搅拌下加热至75℃直到硬脂酸钠溶解。
将得到的混合物冷却至40℃,然后添加本发明的组合物。
xii.乳液,包括身体乳液、面部乳液和手部乳液
xiii.爽身粉和足粉
xiv.洗漱用品
xv.身体喷雾剂
xvi.剃须膏和男性美容产品
xvii.浸浴用品
xviii.去角质磨砂膏
h)个人护理装置
i.面巾
ii.清洁擦拭巾
i)头发护理产品
i.洗发剂(液体和干粉)
ii.护发剂(洗去型调理剂、保留型调理剂和清洁型调理剂)
iii.染发剂
iv.头发清新剂
v.头发香料
vi.头发拉直产品
vii.头发造型产品、头发固定和定型助剂
viii.头发梳理乳膏
ix.发蜡
x.头发发泡剂、发胶、非气溶胶泵喷剂
xi.头发漂白剂、染料和着色剂
xii.烫发剂
xiii.头发擦拭巾
j)美容护理
i.精制香精-含酒精的。用于将香精胶囊掺入到含酒精的精制香精中的组合物和方法在US 4,428,869中描述。含酒精的精制香精可以含有以下:
1.乙醇(1-99%)
2.水(0-99%)
3.悬浮助剂,包括但不限于:羟丙基纤维素、乙基纤维素、二氧化硅、微晶纤维素、角叉菜胶、藻酸丙二醇酯、甲基纤维素、羧甲基纤维素钠或黄原胶(0.1%)
4.任选地,可以包含乳化剂或软化剂,包括但不限于以上列出的那些
ii.固体香料
iii.唇膏/润唇膏
iv.化妆清洁剂
v.护肤化妆品如粉底、面膜、防晒霜、润肤乳液、乳状乳液、润肤霜、润肤剂、皮肤美白剂
vi.美容化妆品,包括美甲、睫毛膏、眼线膏、眼影、液体粉底、粉末粉底、唇膏和腮红
k)消费品包装如香味盒、香味塑料瓶/箱
l)宠物护理产品
i.猫砂
ii.跳蚤和蜱处理产品
iii.宠物美容产品
iv.宠物洗发剂
v.宠物玩具、招待物(treats)和咀嚼物
vi.宠物训练垫
vii.宠物笼和箱
m)糖果,优选地选自由巧克力、巧克力棒产品、其他棒形式的产品、水果胶质、硬和软的焦糖和口香糖组成的组
i.胶质
1.胶基(天然胶乳糖树树胶,大部分当前的口香糖基质目前还包括弹性体,如聚乙酸乙烯酯(PVA)、聚乙烯、(低或中等分子量)聚异丁烯(PIB)、聚丁二烯、异丁烯-异戊二烯共聚物(丁基橡胶)、聚乙烯基乙基醚(PVE)、聚乙烯基丁基醚、乙烯基酯和乙烯基醚的共聚物、苯乙烯-丁二烯共聚物(苯乙烯-丁二烯橡胶,SBR)或乙烯基弹性体,例如基于乙酸乙烯酯/月桂酸乙烯酯、乙酸乙烯酯/硬脂酸乙烯酯或乙烯/乙酸乙烯酯,以及所提到的弹性体的混合物,如例如在EP 0 242 325、美国专利号4,518,615、5,093,136、5,266,336、5,601,858或6,986,709中描述的)20-25%
2.糖粉45-50%
3.葡萄糖15-17%
4.淀粉糖浆10-13%
5.增塑剂0.1%
6.香料0.8-1.2%
上述组分根据前述制剂通过捏合机来捏合以提供口香糖。然后添加囊封的香料或感知剂,并且共混直到均匀。
ii.口气清新剂
iii.口腔可溶条
iv.咀嚼糖
v.硬糖
n)烘烤产品,优选地选自由面包、干饼干、蛋糕和其他小甜饼组成的组;
o)休闲食品,优选地选自由烘烤或油炸的马铃薯片或马铃薯团产品、面包面团产品和基于玉米或花生的挤出物组成的组;
i.马铃薯、玉米粉圆饼、蔬菜或多谷物片
ii.爆米花
iii.椒盐脆饼
iv.膨化零食
p)谷物产品,优选地选自由早餐谷物食品、燕麦坚果棒和预烹制的成品大米产品组成的组
q)含酒精的和不含酒精的饮料,优选地选自由咖啡、茶、葡萄酒、含有葡萄酒的饮料、啤酒、含有啤酒的饮料、利口酒、烈性酒、白兰地、含有水果的苏打水、等渗饮料、软饮料、未冲淡的果汁(nectar)、水果和蔬菜汁和水果或蔬菜制备物组成的组;速溶饮料,优选地选自由速溶可可饮料、速溶茶饮料和速溶咖啡饮料组成的组
i.即饮液体饮品
ii.液体饮品浓缩物
iii.粉末状饮品
iv.咖啡:速溶卡布其诺
1.糖30-40%
2.奶粉24-35%
3.可溶性咖啡20-25%
4.乳糖1-15%
5.食品级乳化剂1-3%
6.囊封的挥发性香料0.01-0.5%
v.茶
vi.含酒精的
r)香辛料调和物和消费预制食品
i.粉末状肉汁、酱混配料
ii.调味料
iii.发酵产品
s)即热食品:即食餐和汤,优选地选自由汤粉、速溶汤、预煮汤组成的组
i.汤
ii.酱
iii.炖菜
iv.冷冻的主菜
t)乳制品奶制品,优选地选自由奶制饮料、冰牛奶、酸奶、开菲尔、奶油奶酪、软奶酪、硬奶酪、奶粉、乳清、黄油、酪乳和含有部分或完全水解的奶蛋白的产品奶味饮料组成的组
i.酸奶
ii.冰淇淋
iii.豆腐
iv.奶酪
u)大豆蛋白或其他大豆级分,优选地选自由豆奶以及由其生成的产品、含有大豆卵磷脂的制备物、发酵产品如豆腐或豆豉或由其生成的产品和酱油组成的组;
v)肉制品,优选地选自由火腿、鲜或生香肠制备物和调味或卤制的鲜肉或咸肉制品组成的组
w)蛋或蛋制品,优选地选自由全蛋粉、蛋白和蛋黄组成的组
x)基于油的产品或其乳液,优选地选自由蛋黄酱、调味酱、调料和调味品制备物组成的组
y)水果制备物,优选地选自由果酱、果汁冰糕、水果沙司和水果馅料组成的组;蔬菜制备物,优选地选自由番茄酱、沙司、干菜、深度冷冻的蔬菜、预烹制的蔬菜、在醋中的蔬菜和泡菜组成的组。
z)调味宠物食品。
以上列出的应用都是本领域中众所周知的。例如,美国专利号6,335,315、5,674,832、5,759,990、5,877,145、5,574,179;5,562,849、5,545,350、5,545,340、5,411,671、5,403,499、5,288,417和4,767,547、4,424,134中描述了织物柔顺剂系统。液体衣物洗涤剂包括在美国专利号5,929,022、5,916,862、5,731,278、5,565,145、5,470,507、5,466,802、5,460,752、5,458,810、5,458,809、5,288,431、5,194,639、4,968,451、4,597,898、4,561,998、4,550,862、4,537,707、4,537,706、4,515,705、4,446,042和4,318,818中描述的那些系统。美国专利号6,069,122和5,990,065中描述了液体碗碟洗涤剂。可以采用本发明的洗发剂和调理剂包括在美国专利号6,162,423、5,968,286、5,935,561、5,932,203、5,837,661、5,776,443、5,756,436、5,661,118、5,618,523、5,275,755、5,085,857、4,673,568、4,387,090和4,705,681中描述的那些。自动碗碟洗涤剂在美国专利号6,020,294、6,017,871、5,968,881、5,962,386、5,939,373、5,914,307、5,902,781、5,705,464、5,703,034、5,703,030、5,679,630、5,597,936、5,581,005、5,559,261、4,515,705、5,169,552和4,714,562中描述。
除非另外指明,则在本文和在权利要求中提到的所有份、百分比和比例都是以重量计的。
本文公开的值和尺寸不被理解为严格限于所记载的精确数值。而是,除非另外详细说明,每个这样的值都旨在意指所记载的值和在该值附近的功能等同范围两者。例如,作为“50%”公开的值旨在意指“约50%”。
术语“包括”、“包含”和“含有”意指非限制性的。
本文中的术语“胶囊”和“微胶囊”可互换地使用。
术语“多官能异氰酸酯(polyfunctional isocyanate)”、“多官能异氰酸酯(multifunctional isocyanate)”和“多异氰酸酯”可互换地使用,并且是指具有两个以上异氰酸酯(-NCO)基团的化合物。
术语“多官能胺(polyfunctional amine)”、“多官能胺(multifunctionalamine)”和“多胺”可互换地使用,并且是指含有一个、两个或更多个伯胺或仲胺基团的化合物。这些术语还指含有一个或多个伯胺/仲胺基团和一个或多个羟基基团(-OH)的化合物。
术语“聚乙烯亚胺(polyethyleneimine)”、“聚乙烯亚胺(polyethyleneimines)”、“聚乙烯亚胺(polyethylenimine)”和“聚乙烯亚胺(polyethylenimines)”可互换地使用。
术语“多官能醇(polyfunctional alcohol)”、“多官能醇(multifunctionalalcohol)”、“多醇(poly alcohol)”和“多元醇(polyol)”可互换地使用,并且是指具有两个以上羟基基团的化合物。
术语“聚合度”是指聚合物中单体单元的数量。
术语“交联度”是指相互连接的单元相对于总重复单元的百分比。其通常通过膨胀实验测定。参见ASTM标准测试方法ASTM D2765-11;Lange,Colloid&Polymer Science 264,488-93(1986)。
术语“多官能亲核试剂(multi-functional nucleophile)”和“多官能亲核体(polyfunctional nucleophile)”在本文中可互换地使用。它们二者都是指在其上连接两个以上亲核基团如伯胺/仲胺基团和羟基基团的脂族烃或芳族烃。
术语“多官能亲电子试剂(multi-functional electrophile)”和“多官能亲电体(polyfunctional electrophile)”可互换地使用并且是指在其上连接两个以上对亲核基团具有反应性的亲电子基团的脂族烃或芳族烃。亲电子基团的实例包括:醛、卤化物、硫酸酯、磺酸酯、环氧化物、氯代醇以及与羰基(包括酮、酰胺或酯)共轭的末端烯烃。
通过以下非限制性实例更详细地描述本发明。在没有进一步阐释的情况下,据信基于本文中的描述,本领域技术人员可以以其最充分的程度利用本发明。本文中引用的所有出版物以其整体通过引用并入。
实施例
按照下述程序制备三种微胶囊浆料,即微胶囊浆料A、B和C。它们用于制备本发明的微胶囊组合物和洗发剂组合物。
微胶囊浆料A
通过混合192克(“g”)的研究香精谐香剂(fragrance accord)(香精A,国际香料和香精公司(International Flavors&Fragrances),Union Beach,NJ)、48g的NEOBEE油M-5(辛酸/癸酸甘油三酯,Stepan,Chicago,IL)和19.2g的苯二甲撑二异氰酸酯的三羟甲基丙烷加合物(由Mitsui Chemicals Corporation,Rye Brook,NY以商标TakenateTM D110-N销售),提供油相。在单独的烧杯中,通过在200.4g的水中混合含有10%聚磺苯乙烯(以商标FLEXANTM II销售,Akzo Nobel,Bridgewater,NJ)的水溶液(30g)和1%CMC(羧甲基纤维素,以商标CRT 50000PA销售,Dow,Midland,MI)的水溶液(60g)来制备水相。在持续三分钟的9500rpm的剪切(ULTRA TURRAX,T25 Basic,IKA WERKE)下将油相乳化到水相中以形成水包油香精乳液。在将香精乳液加热至25℃之后,在恒定搅拌下加入50.4g的30%支化聚乙烯亚胺水溶液(可从巴斯夫(BASF),Florham Park,NJ以商标/>WF商购获得)。将所得胶囊浆料在55℃固化两小时,以获得微胶囊浆料A,其含有未改性的聚脲微胶囊A连同游离的支化聚乙烯亚胺,所述游离的支化聚乙烯亚胺未与多异氰酸酯反应并且不是囊封聚合物一部分。
微胶囊浆料B
通过将微胶囊浆料A用水洗涤三次以移除游离的支化聚乙烯亚胺来制备微胶囊浆料B。
微胶囊浆料C
通过混合186g的研究香精A(国际香料和香精公司)与46.5g的NEOBEE油(Stepan)来提供油相。在单独的烧杯中,通过将4.5g的30%鲸蜡基三甲基氯化铵溶液(“CTAC”,AIC,Framinghan,MA)溶解在130.5g的水中来制备水相。在持续两分钟的9500rpm的高剪切下将油相乳化到水相中以形成水包油香精乳液。向乳液中添加193.4g的水和40.3g的四原硅酸盐(Evonik,Parsippany,NJ)。将所得浆料在室温(大约25℃)固化48小时,以获得含有二氧化硅微胶囊C的微胶囊浆料C。
实施例1-31
组合物1
通过将微胶囊浆料B与丙烯酸反应来制备组合物1。更具体地,将1g的胶囊浆料B与1g的丙烯酸(Sigma Aldrich,St Louis,MO)在室温(大约25℃)混合36小时。然后将混合物离心并且通过移液管移除水层。将所得胶囊浆料再次用水(1至2mL)洗涤,离心,并且使用移液管与水层分离。将洗涤步骤重复5次,以获得含有改性微胶囊1的组合物1,所述改性微胶囊1具有经丙烯酸改性的聚脲微胶囊壁。
在改性微胶囊1中,羧酸部分经由胺键化学键合至微胶囊壁的表面,所述胺键通过微胶囊A表面上的伯胺或仲胺基团与α,β-不饱和羧酸(丙烯酸)之间的迈克尔加成反应形成。
组合物2
按照与组合物1相同的程序制备组合物2,不同之处在于反应在50℃进行24小时。
组合物3
按照与组合物1相同的程序制备组合物3,不同之处在于使用缩水甘油基三甲基氯化铵(Sigma Aldrich,St.Louis,MO)代替丙烯酸。由此制备的组合物3含有改性微胶囊3,所述改性微胶囊3具有经缩水甘油基三甲基氯化铵改性的聚脲微胶囊壁。
微胶囊壁经由共价键(即,羟胺基团)具有三甲基氯化铵部分,所述共价键通过微胶囊壁表面上的伯胺或仲胺基团与缩水甘油基三甲基氯化铵中的缩水甘油基基团之间的反应形成。
组合物4
按照与组合物3相同的程序制备组合物4,不同之处在于反应在50℃进行24小时。
组合物5
通过将支化聚乙烯亚胺与缩水甘油基三甲基氯化铵反应来制备组合物5。更具体地,将1.7g的30%支化聚乙烯亚胺水溶液(可以商标Wf(BASF,Florham Park,NJ)商购获得)与1g的25%氢氧化钠(Signa-Aldrich,St.Louis,MO)和17.3g的水混合。向所得溶液中添加1g的缩水甘油基三甲基氯化铵并且在55℃搅拌16小时,以获得含有改性聚乙烯亚胺5的组合物5。
改性聚乙烯亚胺具有经由羟胺基团共价键合至支化聚乙烯亚胺的三甲基氯化铵部分,其通过支化聚乙烯亚胺上的伯胺或仲胺基团与缩水甘油基基团之间的开环反应形成。
组合物6
按照与组合物5相同的程序制备组合物6,不同之处在于使用3-氯-2-羟基丙基)三甲基氯化铵代替缩水甘油基三甲基氯化铵。由此制备的组合物6具有经由羟胺基团共价键合至支化聚乙烯亚胺的三甲基氯化铵部分,其通过用3-氯-2-羟基丙基)三甲基氯化铵中的氯基团取代支化聚乙烯亚胺上的伯胺或仲胺基团形成。
组合物7
通过将20g的微胶囊浆料A与0.25g的缩水甘油基三甲基氯化铵(Sigma Aldrich)在pH 11和室温下反应24小时来制备组合物7。由此制备的组合物7含有改性微胶囊3和改性聚乙烯亚胺5。
组合物8
通过将20g的微胶囊浆料A和0.27g的缩水甘油基三甲基氯化铵(Sigma Aldrich)以及1g的支化聚乙烯亚胺(可以商标WF(BASF)商购获得)在室温反应24小时来制备组合物8。
由此制备的组合物8含有改性微胶囊3和改性聚乙烯亚胺5。
组合物9
通过将20g的微胶囊浆料A和0.5g的N,N-二甲基丙烯酰胺(Sigma Aldrich)以及750ppm 4-甲氧基苯酚(Sigma Aldrich,作为催化剂)在50℃反应24小时来制备组合物9。
由此制备的组合物9含有改性微胶囊9,所述改性微胶囊9具有经N,N-二甲基丙烯酰胺改性的聚脲微胶囊壁。
在改性微胶囊9中,N,N-二甲基酰胺部分经由胺键化学键合至微胶囊壁的表面,所述胺键通过微胶囊A表面上的伯胺或仲胺基团与α,β-不饱和酰胺(N,N-二甲基丙烯酰胺)之间的迈克尔加成反应形成。
使用含有游离的支化聚乙烯亚胺的微胶囊浆料A来制备组合物9。在制备期间,游离的支化聚乙烯亚胺也与N,N-二甲基丙烯酰胺反应。因此,组合物9还含有改性聚乙烯亚胺9,所述改性聚乙烯亚胺9具有经由胺基团共价键合至支化聚乙烯亚胺的N,N-二甲基酰胺部分,其通过支化聚乙烯亚胺中的伯胺或仲胺基团与α,β-不饱和酰胺(N,N-二甲基丙烯酰胺)之间的迈克尔加成反应形成。
组合物10
通过将20g的微胶囊浆料A和0.5g的N-(异丁氧基甲基)丙烯酰胺(Sigma Aldrich)以及750ppm 4-甲氧基苯酚(Sigma Aldrich,作为催化剂)在室温(约25℃)反应24小时来制备组合物10。
由此制备的组合物10含有改性微胶囊10,所述改性微胶囊10具有经N-(异丁氧基甲基)丙烯酰胺改性的聚脲微胶囊壁。
在改性微胶囊10中,N-异丁氧基甲基酰胺部分经由胺键化学键合至微胶囊壁的表面,所述胺键通过微胶囊A表面上的伯胺或仲胺基团与α,β-不饱和酰胺(N-(异丁氧基甲基)丙烯酰胺)之间的迈克尔加成反应形成。
另外,组合物10还含有改性聚乙烯亚胺10,所述改性聚乙烯亚胺10具有经由胺基团共价键合至支化聚乙烯亚胺的N-异丁氧基甲基酰胺部分,其通过支化聚乙烯亚胺中的伯胺或仲胺基团与α,β-不饱和酰胺(N-(异丁氧基甲基)丙烯酰胺)之间的迈克尔加成反应形成。
组合物11
通过将20g的微胶囊浆料A和0.5g的甲基丙烯酰胺基乙基亚乙基脲(MAEEU,可从Solvay,Cranbury,NJ以商标SipomerTM WAM II商购获得)以及750ppm 4-甲氧基苯酚(SigmaAldrich,作为催化剂)在室温(约25℃)反应24小时来制备组合物11。
由此制备的组合物11含有具有聚脲微胶囊壁的改性微胶囊11,其中甲基丙烯酰胺基乙基亚乙基脲部分共价键合至所述聚脲微胶囊壁。
在改性微胶囊11中,亚乙基脲经由胺键化学键合至微胶囊壁的表面,所述胺键通过微胶囊A表面上的伯胺或仲胺基团与α,β-不饱和酰胺(N-(异丁氧基甲基)丙烯酰胺)之间的迈克尔加成反应形成。
另外,组合物11还含有改性聚乙烯亚胺11,所述改性聚乙烯亚胺11具有经由胺基团共价键合至支化聚乙烯亚胺的亚乙基脲部分,其通过支化聚乙烯亚胺中的伯胺或仲胺基团与甲基丙烯酰胺基乙基亚乙基脲之间的迈克尔加成反应形成。
组合物12
通过将20g的微胶囊浆料A和0.05g三羟甲基丙烷三缩水甘油基醚(Sigma-Aldrich,St.Louis,MO)在pH 11和室温(约25℃)下反应24小时来制备组合物12。
由此制备的组合物12含有具有聚脲微胶囊壁的改性微胶囊12,其中三羟甲基丙烷部分共价键合至所述聚脲微胶囊壁。
在改性微胶囊12中,三羟甲基丙烷经由羟胺键化学键合至微胶囊壁的表面,所述羟胺键通过微胶囊A表面上的伯胺或仲胺基团与缩水甘油基基团之间的开环反应形成。
另外,组合物12还含有改性聚乙烯亚胺12,所述改性聚乙烯亚胺12具有经由羟胺基团共价键合至支化聚乙烯亚胺的三羟甲基丙烷部分,其通过支化聚乙烯亚胺中的伯胺或仲胺基团与三羟甲基丙烷三缩水甘油基醚之间的开环反应形成。
组合物13
通过将20g的微胶囊浆料A和溶解在Neobee油(Stepan,Northfield,IL)中的0.05g三羟甲基丙烷三缩水甘油基醚(Sigma-Aldrich,St.Louis,MO)在pH 11和室温(约25℃)下反应24小时来制备组合物13。
由此制备的组合物13含有改性微胶囊12和改性聚乙烯亚胺12。
组合物14
通过将20g的微胶囊浆料B和0.05g三羟甲基丙烷三缩水甘油基醚(Sigma-Aldrich,St.Louis,MO)在pH 11和室温(约25℃)下反应24小时来制备组合物14。
由此制备的组合物14含有改性微胶囊12。
组合物15
通过将20g的微胶囊浆料B、0.05g三羟甲基丙烷三缩水甘油基醚(Sigma-Aldrich,St.Louis,MO)和按组合物15的重量计1.2%的水平的支化聚乙烯亚胺(可以商标WF(BASF)商购获得)反应来制备组合物15。将混合物在pH 11和室温(约25℃)下搅拌24小时。
由此制备的组合物15含有改性微胶囊12和改性聚乙烯亚胺12。
组合物16
通过将20g的微胶囊浆料A、1g的3-(甲基丙烯酰基氨基)丙基]三甲基氯化铵(Sigma-Aldrich,St.Louis,MO)和750ppm 4-甲氧基苯酚(Sigma Aldrich)在室温(约25℃)反应24小时来制备组合物16。
由此制备的组合物16含有具有聚脲微胶囊壁的改性微胶囊16,其中三甲基氯化铵部分共价键合至所述聚脲微胶囊壁。
在改性微胶囊16中,三甲基氯化铵部分经由胺键化学键合至微胶囊壁的表面,所述胺键通过微胶囊A表面上的伯胺或仲胺基团与3-(甲基丙烯酰基氨基)丙基]三甲基氯化铵之间的迈克尔加成反应形成。
另外,组合物16还含有改性聚乙烯亚胺16,所述改性聚乙烯亚胺16具有经由胺基团共价键合至支化聚乙烯亚胺的三甲基氯化铵部分,其通过支化聚乙烯亚胺中的伯胺或仲胺基团与3-(甲基丙烯酰基氨基)-丙基]三甲基氯化铵之间的迈克尔加成反应形成。
组合物17
通过将20g的微胶囊浆料A、1g的(3-丙烯酰胺基丙基)三甲基氯化铵(Sigma-Aldrich)和750ppm 4-甲氧基苯酚(Sigma Aldrich)在室温(约25℃)反应24小时来制备组合物17。
由此制备的组合物17含有具有聚脲微胶囊壁的改性微胶囊17,其中三甲基氯化铵部分共价键合至所述聚脲微胶囊壁。
在改性微胶囊17中,三甲基氯化铵部分经由胺键化学键合至微胶囊壁的表面,所述胺键通过微胶囊A表面上的伯胺或仲胺基团与(3-丙烯酰胺基丙基)三甲基氯化铵之间的迈克尔加成反应形成。
另外,组合物17还含有改性聚乙烯亚胺17,所述改性聚乙烯亚胺17具有经由胺基团共价键合至支化聚乙烯亚胺的三甲基氯化铵部分,其通过支化聚乙烯亚胺中的伯胺或仲胺基团与(3-丙烯酰胺基丙基)-三甲基氯化铵之间的迈克尔加成反应形成。
组合物18
通过将20g的微胶囊浆料A、1g的N-[三(羟基甲基)甲基]丙烯酰胺(Sigma-Aldrich)和750ppm 4-甲氧基苯酚(Sigma-Aldrich)在室温(约25℃)反应24小时来制备组合物18。
由此制备的组合物18含有具有聚脲微胶囊壁的改性微胶囊18,其中三(羟基甲基)甲基部分共价键合至所述聚脲微胶囊壁。
在改性微胶囊18中,三(羟基甲基)甲基部分经由胺键化学键合至微胶囊壁的表面,所述胺键通过微胶囊A表面上的伯胺或仲胺基团与N-[三(羟基甲基)甲基]丙烯酰胺之间的迈克尔加成反应形成。
另外,组合物18还含有改性聚乙烯亚胺18,所述改性聚乙烯亚胺18具有经由胺基团共价键合至支化聚乙烯亚胺的三(羟基甲基)甲基部分,其通过支化聚乙烯亚胺中的伯胺或仲胺基团与N-[三(羟基甲基)-甲基]丙烯酰胺之间的迈克尔加成反应形成。
组合物19
通过将20g的微胶囊浆料A、1g的丙烯酰胺(Sigma-Aldrich)和750ppm 4-甲氧基苯酚(Sigma-Aldrich)在室温(约25℃)反应24小时来制备组合物19。
由此制备的组合物19含有具有聚脲微胶囊壁的改性微胶囊19,其中酰胺部分共价键合至所述聚脲微胶囊壁。
在改性微胶囊19中,酰胺部分经由胺键化学键合至微胶囊壁的表面,所述胺键通过微胶囊A表面上的伯胺或仲胺基团与丙烯酰胺之间的迈克尔加成反应形成。
另外,组合物19还含有改性聚乙烯亚胺19,所述改性聚乙烯亚胺19具有经由胺基团共价键合至支化聚乙烯亚胺的酰胺部分,其通过支化聚乙烯亚胺中的伯胺或仲胺基团与丙烯酰胺之间的迈克尔加成反应形成。
组合物20
通过将20g的微胶囊浆料A、1g的N-(3,4-二羟基苯乙基)丙烯酰胺(可从AlfaChemistry商购获得)和750ppm 4-甲氧基苯酚(Sigma-Aldrich)在室温(约25℃)反应24小时来制备组合物20。
由此制备的组合物20含有具有聚脲微胶囊壁的改性微胶囊20,其中二羟基苯基部分共价键合至所述聚脲微胶囊壁。
在改性微胶囊20中,二羟基苯乙基部分经由胺键化学键合至微胶囊壁的表面,所述胺键通过微胶囊A表面上的伯胺或仲胺基团与N-(3,4-二羟基苯乙基)丙烯酰胺之间的迈克尔加成反应形成。
另外,组合物20还含有改性聚乙烯亚胺20,所述改性聚乙烯亚胺20具有经由胺基共价键合至支化聚乙烯亚胺的二羟基苯基部分,其通过支化聚乙烯亚胺中的伯胺或仲胺基团与N-(3,4-二羟基苯乙基)丙烯酰胺之间的迈克尔加成反应形成。
组合物21
通过将20g的微胶囊浆料A、1g的氧化苯乙烯(Sigma-Aldrich)在室温(约25℃)反应24小时来制备组合物21。
由此制备的组合物21含有具有聚脲微胶囊壁的改性微胶囊21,其中苯基部分共价键合至所述聚脲微胶囊壁。
在改性微胶囊21中,苯基部分经由羟胺键化学键合至微胶囊壁的表面,所述羟胺键通过微胶囊A表面上的伯胺或仲胺基团与氧化苯乙烯之间的开环反应形成。
另外,组合物21还含有改性聚乙烯亚胺21,所述改性聚乙烯亚胺21具有经由羟胺基团共价键合至支化聚乙烯亚胺的苯基部分,其通过支化聚乙烯亚胺中的伯胺或仲胺基团与氧化苯乙烯之间的迈克尔加成反应形成。
组合物22
通过将20g的微胶囊浆料A、0.025g的4-(丙-2-烯酰胺基甲基)苯甲酸(Sigma-Aldrich)和750ppm 4-甲氧基苯酚(Sigma-Aldrich)在室温(约25℃)反应24小时来制备组合物22。
由此制备的组合物22含有具有聚脲微胶囊壁的改性微胶囊22,其中苯甲酸部分共价键合至所述聚脲微胶囊壁。在该微胶囊中,苯甲酸部分经由胺键化学键合至微胶囊壁的表面,所述胺键通过微胶囊A表面上的伯胺或仲胺基团与4-(丙-2-烯酰胺基甲基)苯甲酸之间的迈克尔加成反应形成。
另外,组合物22还含有改性聚乙烯亚胺22,所述改性聚乙烯亚胺22具有经由胺基团共价键合至支化聚乙烯亚胺的苯甲酸部分,其通过支化聚乙烯亚胺中的伯胺或仲胺基团与4-(丙-2-烯酰胺基甲基)苯甲酸之间的迈克尔加成反应形成。
组合物23
通过将20g的微胶囊浆料A、1g的2-乙基己基缩水甘油基醚(Sigma-Aldrich)在室温(约25℃)反应24小时来制备组合物23。
由此制备的组合物23含有具有聚脲微胶囊壁的改性微胶囊23,其中2-乙基己基部分共价键合至所述聚脲微胶囊壁。
在改性微胶囊23中,2-乙基己基部分经由羟胺键化学键合至微胶囊壁的表面,所述羟胺键通过微胶囊A表面上的伯胺或仲胺基团与2-乙基己基缩水甘油基醚之间的开环反应形成。
另外,组合物23还含有改性聚乙烯亚胺23,所述改性聚乙烯亚胺23具有经由羟胺基团共价键合至支化聚乙烯亚胺的2-乙基己基部分,其通过支化聚乙烯亚胺中的伯胺或仲胺基团与2-乙基己基缩水甘油基醚之间的开环反应形成。
组合物24
通过将20g的微胶囊浆料A和0.1g的(3-缩水甘油基氧基丙基)三甲氧基硅烷(Sigma-Aldrich)在室温反应24小时来制备组合物24。
由此制备的组合物24含有具有聚脲微胶囊壁的改性微胶囊24,其中三甲氧基甲硅烷基部分共价键合至所述聚脲微胶囊壁。
在改性微胶囊24中,三甲氧基甲硅烷基部分经由羟胺键化学键合至微胶囊壁的表面,所述羟胺键通过微胶囊A表面上的伯胺或仲胺基团与(3-缩水甘油基氧基丙基)三甲氧基硅烷之间的开环反应形成。
另外,组合物24还含有改性聚乙烯亚胺24,所述改性聚乙烯亚胺24具有经由羟胺基团共价键合至支化聚乙烯亚胺的三甲氧基甲硅烷基部分,其通过支化聚乙烯亚胺中的伯胺或仲胺基团与(3-缩水甘油基氧基丙基)三甲氧基硅烷之间的开环反应形成。
组合物25
通过将20g的微胶囊浆料A、0.5g的丙烯酰胺(Sigma-Aldrich)、0.5g缩水甘油基三甲基氯化铵(Sigma Aldrich)和750ppm 4-甲氧基苯酚(Sigma-Aldrich)在室温(约25℃)反应24小时来制备组合物25。
由此制备的组合物25含有具有聚脲微胶囊壁的改性微胶囊25,其中以下两个部分共价键合至所述聚脲微胶囊壁:(i)酰胺部分和(ii)三甲基氯化铵部分。
在改性微胶囊25中,以下两个部分化学键合至微胶囊壁的表面:(i)酰胺部分和(ii)三甲基氯化铵部分。酰胺部分经由胺键键合,所述胺键通过微胶囊A表面上的伯胺或仲胺基团与丙烯酰胺之间的迈克尔加成反应形成。三甲基氯化铵部分经由羟胺键键合,所述羟胺键通过微胶囊A表面上的伯胺或仲胺基团与缩水甘油基三甲基氯化铵之间的开环反应形成。
另外,组合物25还含有具有酰胺部分和三甲基氯化铵部分的改性聚乙烯亚胺25,所述酰胺部分和三甲基氯化铵部分二者经由胺或羟胺基团共价键合至支化聚乙烯亚胺。
组合物26
通过将20g的微胶囊浆料A、0.5g的丙烯酰胺、0.5g的[3-(甲基丙烯酰基氨基)丙基]三甲基氯化铵(Sigma Aldrich)和750ppm 4-甲氧基苯酚在室温反应24小时来制备组合物26。
由此制备的组合物26含有具有聚脲微胶囊壁的改性微胶囊26,其中以下两个部分共价键合至所述聚脲微胶囊壁:(i)酰胺部分和(ii)三甲基氯化铵部分。
在改性微胶囊26中,以下两个部分化学键合至微胶囊壁的表面:(i)酰胺部分和(ii)三甲基氯化铵部分。酰胺部分经由胺键键合,所述胺键通过微胶囊A表面上的伯胺或仲胺基团与丙烯酰胺之间的迈克尔加成反应形成。三甲基氯化铵部分经由胺键键合,所述胺键通过微胶囊A表面上的伯胺或仲胺基团与[3-(甲基丙烯酰基氨基)丙基]三甲基氯化铵之间的迈克尔加成反应形成。
另外,组合物26还含有具有酰胺部分和三甲基氯化铵部分的改性聚乙烯亚胺26,所述酰胺部分和三甲基氯化铵部分二者经由单独的胺基团共价键合至支化聚乙烯亚胺。
组合物27
通过将20g的微胶囊浆料A、0.5g的丙烯酰胺、0.5g的(3-丙烯酰胺基丙基)三甲基氯化铵和750ppm 4-甲氧基苯酚在室温反应24小时来制备组合物27。
由此制备的组合物27含有具有聚脲微胶囊壁的改性微胶囊27,其中以下两个部分共价键合至所述聚脲微胶囊壁:(i)酰胺部分和(ii)三甲基氯化铵部分。
在改性微胶囊27中,以下两个部分化学键合至微胶囊壁的表面:(i)酰胺部分和(ii)三甲基氯化铵部分。酰胺部分经由胺键键合,所述胺键通过微胶囊A表面上的伯胺或仲胺基团与丙烯酰胺之间的迈克尔加成反应形成。三甲基氯化铵部分经由胺键键合,所述胺键通过微胶囊A表面上的伯胺或仲胺基团与(3-丙烯酰胺基丙基)三甲基氯化铵之间的迈克尔加成反应形成。
另外,组合物27还含有具有酰胺部分和三甲基氯化铵部分的改性聚乙烯亚胺27,所述酰胺部分和三甲基氯化铵部分二者经由单独的胺基团共价键合至支化聚乙烯亚胺。
组合物28
通过将20g的微胶囊浆料A、0.5g的N-[三(羟基甲基)甲基]丙烯酰胺(SigmaAldrich)、0.5g的缩水甘油基三甲基氯化铵(Sigma Aldrich)和750ppm 4-甲氧基苯酚在室温反应24小时来制备组合物28。
由此制备的组合物28含有具有聚脲微胶囊壁的改性微胶囊28,其中以下两个部分共价键合至所述聚脲微胶囊壁:(i)三(羟基甲基)甲基部分和(ii)三甲基氯化铵部分。
在改性微胶囊28中,以下两个部分化学键合至微胶囊壁的表面:(i)三(羟基甲基)甲基部分和(ii)三甲基氯化铵部分。三(羟基甲基)甲基部分经由胺键键合,所述胺键通过微胶囊A表面上的伯胺或仲胺基团与N-[三(羟基甲基)甲基]丙烯酰胺之间的迈克尔加成反应形成。三甲基氯化铵部分经由羟胺键键合,所述羟胺键通过微胶囊A表面上的伯胺或仲胺基团与缩水甘油基三甲基氯化铵之间的开环反应形成。
另外,组合物28还含有具有三(羟基甲基)甲基部分和三甲基氯化铵部分的改性聚乙烯亚胺28,所述三(羟基甲基)甲基部分和三甲基氯化铵部分二者经由胺或羟胺基团共价键合至支化聚乙烯亚胺。
组合物29
通过将20g的微胶囊浆料A、0.5g的丙烯酸(Sigma Aldrich)、0.5g的缩水甘油基三甲基氯化铵(Sigma Aldrich)和750ppm 4-甲氧基苯酚在室温反应24小时来制备组合物29。
由此制备的组合物29含有具有聚脲微胶囊壁的改性微胶囊29,其中以下两个部分共价键合至所述聚脲微胶囊壁:(i)羧酸部分和(ii)三甲基氯化铵部分。
在改性微胶囊29中,以下两个部分化学键合至微胶囊壁的表面:(i)羧酸部分和(ii)三甲基氯化铵部分。羧酸部分经由胺键键合,所述胺键通过微胶囊A表面上的伯胺或仲胺基团与丙烯酸之间的迈克尔加成反应形成。三甲基氯化铵部分经由羟胺键键合,所述羟胺键通过微胶囊A表面上的伯胺或仲胺基团与缩水甘油基三甲基氯化铵之间的开环反应形成。
另外,组合物29还含有具有羧酸部分和三甲基氯化铵部分的改性聚乙烯亚胺29,所述羧酸部分和三甲基氯化铵部分二者经由胺或羟胺基团共价键合至支化聚乙烯亚胺。
组合物30
通过将18g的微胶囊浆料A、8g的微胶囊浆料C和0.25g的(3-缩水甘油基氧基丙基)三甲氧基硅烷(Sigma-Aldrich)在pH 11和室温下反应24小时来制备组合物30。
由此制备的组合物30含有具有聚脲微胶囊壁的改性微胶囊30,其中三甲氧基硅烷部分共价键合至所述聚脲微胶囊壁。
在改性微胶囊30中,三甲氧基甲硅烷基部分经由羟胺键化学键合至微胶囊壁的表面,所述羟胺键通过微胶囊A表面上的伯胺或仲胺基团与(3-缩水甘油基氧基丙基)三甲氧基硅烷之间的开环反应形成。
另外,组合物30还含有具有二氧化硅微胶囊壁的改性二氧化硅微胶囊30,其中三甲氧基甲硅烷基部分共价键合至所述二氧化硅微胶囊壁。
组合物31
通过将50g的微胶囊浆料A、1.9g的癸醛(国际香料和香精公司)在55℃反应5小时来制备组合物31。
由此制备的组合物31含有具有聚脲微胶囊壁的改性微胶囊31,其中亚胺部分共价键合至所述聚脲微胶囊壁。
在改性微胶囊31中,亚胺部分经由亚胺键化学键合至微胶囊壁的表面,所述亚胺键通过微胶囊A表面上的伯胺基团与醛(癸醛)之间的反应形成。
ζ电位
使用Malvern Zetasizer(可从Malvern,Inc.商购获得)来测量微胶囊组合物的ζ电位。将微胶囊组合物(0.2g)用99.8g的水稀释以制得0.2%测试溶液用于测量。遵循由Zetasizer提供的实验方案。对微胶囊浆料A和B以及微胶囊组合物1-4进行评价。
微胶囊浆料A的ζ电位为+58.61mV。
微胶囊浆料B的ζ电位为+74.65mV。
微胶囊组合物1的ζ电位为+22.66mV。
微胶囊组合物2的ζ电位为-25.16mV。
微胶囊组合物3的ζ电位为+45.12mV。
微胶囊组合物4的ζ电位为+42.44mV。
红外光谱
使用Nicolet 6700FT-IR光谱仪(可从Thermo Scientific商购获得)来测量微胶囊组合物的红外光谱。使用干燥胶囊样品进行测量。基于微胶囊组合物1和2的红外光谱,并未观察到通常从C=C伸缩观察到的特征峰(丙烯酸,1637cm-1),表明通过丙烯酸的化学反应进行了表面改性。此外,也未观察到=C-H弯曲在933cm-1处的吸收,表明在反应中消耗了丙烯酸。相比于微胶囊浆料B,O-H伸缩(3320-3340cm-1)、C-N伸缩(1180-1240cm-1)的吸收增加和C=O的轻微位移(从1700cm-1至1730cm-1)确认了表面改性。对于微胶囊组合物3和4,存在O-H伸缩(3325cm-1)和C-N伸缩(1180-1240cm-1)的吸收增加,表明形成羟基基团,其由缩水甘油基基团的开环反应产生。并未观察到表明缩水甘油基三甲基氯化铵中的环氧化物的在1266cm-1和869cm-1处的峰。此外,并未观察到大约815-950cm-1处的不对称环氧环变形峰。
HPLC
高效液相色谱(HPLC)分析分别显示出微胶囊组合物1和2中13.49mmol(0.39mmol,28.1mg反应)和13.06mmol(0.82mmol,59.1mg反应)的残余丙烯酸含量。结果表明在胶囊表面消耗过量丙烯酸。两倍的差异也与组合物1和2相对于聚脲微胶囊3的ζ电位变化一致。
NMR光谱:游离BPEI官能化
使用Bruker的13C-NMR光谱仪研究微胶囊组合物5和6中支化聚乙烯亚胺(BPEI)的官能度。
由起始材料缩水甘油基三甲基氯化铵制备微胶囊组合物5。该起始材料在NMR光谱上显示出以下峰:(i)53.5ppm(对于三甲基铵基团N(CH3)3)、(ii)68ppm(对于-CH2-N(CH3)3的CH2基团上的碳原子)和(iii)45ppm和45.7ppm处的两个峰(对于缩水甘油基基团-CH2-O-(CH-)-)。在反应完成后,(i)53.5ppm处的峰消失并且在55ppm处发现新峰,(ii)68ppm处的峰消失并且在69.5ppm处观察到新峰,并且(iii)45ppm和45.7ppm处的两个峰消失,表明缩水甘油基基团开环。NMR中的变化表明三甲基铵基团与BPEI的共价键合。
由起始材料(3-氯-2-羟基丙基)三甲基氯化铵制备微胶囊组合物6。该起始材料在NMR光谱上显示出以下峰:(i)53.5ppm(对于三甲基铵基团N(CH3)3)、(ii)68.1ppm(对于-CH2-N(CH3)3的CH2基团上的碳原子)和(iii)47.9ppm处的峰(对于3-氯-2-羟基丙基基团-C-Cl)。在反应完成后,(i)53.5ppm处的峰消失并且在55ppm处发现新峰,(ii)68.1ppm处的峰消失并且在70.5ppm处观察到新峰,并且(iii)47.9处的峰消失,表明Cl的取代。NMR中的变化表明三甲基铵基团与BPEI的共价键合。
实施例32-45
洗发剂组合物
通过分别将微胶囊组合物10-13、15、17-21和24-30和未加香精的模型洗发剂(例如可从Magic Botanicals,纽约商购获得)在4000-6000rpm的剪切速率下混合2分钟来制备洗发剂组合物S10-13、S15、S17-21和S24-S30。由此制备的洗发剂组合物各自含有0.5%香精油(即,0.5%净油当量或NOE)。以相同的方式制备比较洗发剂,不同之处在于使用微胶囊浆料A代替本发明的微胶囊组合物中的一者。
沉积评价
本发明的微胶囊组合物显示出与比较洗发剂相比出乎意料地在头发上的高沉积率。
为了评价洗发剂组合物S10的沉积率,将2g的组合物连同外标添加至2束湿头发样本(8股)。在起泡后,将头发样本在350mL热水中冲洗,然后晾干24小时,随后使用甲醇萃取并且使用GC分析。使用外标作为100重量%来计算沉积率(以重量%计)。
按照相同的程序,确定比较洗发剂以及洗发剂组合物S11-13、S15、S17-21和S24-S30的沉积率(重量%)。
比较洗发剂的沉积率为3%。洗发剂组合物S11-13、S15、S17-21和S24-S30中的每一个都具有至少21%的沉积率,其是比较洗发剂的7倍。
实施例46-61
护发剂组合物
通过分别将微胶囊组合物7-10、12、13、15-17和21-29与模型护发剂混合来制备护发剂组合物HC7-10、HC12、HC13、HC15-17和HC21-29。由此制备的护发剂组合物各自含有0.5%香精油(即,0.5%净油当量或NOE)。
以相同的方式制备比较护发剂,不同之处在于使用微胶囊浆料A代替本发明的微胶囊组合物。
沉积评价
本发明的微胶囊组合物显示出与比较护发剂相比在护发剂用途中出乎意料地高沉积率。
为了评价护发剂组合物HC7的沉积率,将2g的组合物连同外标(3a,4,5,6,7,7a-六氢-1H-4,7-亚甲基茚-1-基丙酸酯,可从IFF,Union Beach,NJ以商标商购获得)添加至2束湿头发样本(8股)。在起泡后,将头发样本在350mL热水中冲洗,然后晾干24小时,随后使用甲醇萃取并且使用GC分析。使用外标作为100重量%来计算沉积率(以重量%计)。
按照相同的程序,确定比较护发剂以及护发剂组合物HC8-10、HC12、HC13、HC15-17和HC21-29的沉积率(重量%)。比较护发剂的沉积率为4%。护发剂组合物HC8-10、HC12、HC13、HC15-17和HC21-29中的每一个都具有至少40%的沉积率,其是比较护发剂的10倍。
香精强度评价
评判员小组评价了用比较护发剂、护发剂HC7和HC12处理的头发的香精强度。在如上所述用护发剂处理头发样本并且晾干(lined-tried)24小时后,评判员小组对它们进行嗅闻,然后以范围为0至10的等级进行评级。数值5表明头发样本产生强的强度,而值10表明头发样本产生非常强的气味。一个头发样本在不进行梳理的情况下进行评价以获得梳理前(pre-brush)香精强度,并且另一个头发样本用于获得在用梳子梳理头发样本后的梳理后(post-brush)香精强度。
比较护发剂具有0.8的梳理前香精强度和2.9的梳理后香精强度。
护发剂HC7具有1的梳理前香精强度和5.6的梳理后香精强度。
护发剂HC12具有1.75的梳理前香精强度和525的梳理后香精强度。
微胶囊之间的交联
组合物30的显微照片示出了聚脲微胶囊A(直径为10微米的粒度)被多个二氧化硅微胶囊C(具有直径为2微米的尺寸)交联并包围。
醛释放增强
将微胶囊浆料1和组合物31分别给料至不含香精的喷雾淀粉基质的溶液中以用于感官和顶空评价。将复合物以0.5%(wt/wt)给料至喷雾淀粉基质中,并且使用Silverson均化器以4000RPM均化以确保均匀的混合物。将喷雾淀粉放入泵式喷雾瓶中。将0.5g的喷雾淀粉溶液的等分试样施加至擦手毛巾(hand cloth),之后立即进行熨烫评价。
然后使用以下方案评价上述样品。将含有喷雾淀粉的毛巾折叠一次,并且放在塑料盒下方。将收集管置于盒盖下方。并且使用750ml/min的收集速率对平衡空气的顶部空间进行采样1分钟,以获得熨烫前(pre-iron)浓度。然后将毛巾熨烫15秒,并且立即盖在塑料盒中。使用750ml/min的收集速率达1分钟来测量顶空浓度,以获得熨烫后(post-iron)浓度。
结果显示出微胶囊A具有0ng/L的熨烫前浓度和2ng/L的熨烫后浓度。相比之下,本发明的组合物31具有152ng/L的熨烫前浓度和486ng/L的熨烫后浓度。
其他实施方案
本说明书中公开的所有特征都可以以任意组合合并。本说明书中公开的每个特征都可以被用作相同、等同或相似目的的备选特征替换。因此,除非另外明确说明,公开的每个特征都仅是等同或相似特征的通用系列的实例。
实际上,为了实现沉积活性材料的目的,本领域技术人员可以通过使用不同的囊封聚合物、涂层、多官能亲核试剂和/或亲电子试剂和/或胶囊形成助剂,改变这些形成壁的材料和/或催化剂的浓度来设计和制备胶囊组合物,以实现消费品中的期望感官或释放性质。另外,多官能亲核试剂和/或亲电子试剂、胶囊形成助剂、辅剂、芯改性剂、活性材料和催化剂之间的比率也可以由技术人员通过本领域已知的试验来确定,以制备具有所需性质的胶囊组合物。
根据以上描述,技术人员可以容易地确定本发明的必要特征,并且在不脱离其实质和范围的情况下,可以对本发明进行多种变化和改变以使其适合于多种用途和条件。因此,其他实施方案也在权利要求范围内。
Claims (44)
1.一种制备微胶囊组合物的方法,所述方法包括以下步骤:
(a)提供含有多个微胶囊的微胶囊浆料,其中每个微胶囊具有微胶囊芯和囊封所述微胶囊芯的微胶囊壁,并且具有内表面和外表面的所述微胶囊壁由具有伯胺或仲胺基团的囊封聚合物形成,
(b)提供具有反应性基团的沉积剂,以及
(c)在所述伯胺或仲胺基团和所述反应性基团之间形成共价键以将所述沉积剂接枝到所述微胶囊壁的所述外表面上的所述囊封聚合物以获得表面改性的微胶囊,
其中所述沉积剂是缩水甘油基三甲基铵盐、N-(2-(2-氧代咪唑烷-1-基)乙基)甲基丙烯酰胺、N-(2-(2-氧代咪唑烷-1-基)乙基)丙烯酰胺、N-(3,4-二羟基苯乙基)甲基丙烯酰胺、3,4-二羟基苯甲醛、[3-(甲基丙烯酰基氨基)丙基]三甲基氯化铵、(3-丙烯酰胺基丙基)三甲基铵或其组合,并且所述微胶囊芯含有香精。
2.根据权利要求1所述的方法,其中所述微胶囊芯还含有香精前体、香料、恶臭中和剂、维生素、抗炎剂、杀真菌剂、麻醉剂、止痛剂、抗病毒剂、祛痘剂、皮肤光亮剂、驱昆虫剂、兽用驱避剂、软化剂、皮肤保湿剂、皱纹控制剂、UV防护剂、织物柔顺剂活性成分、硬表面清洁活性成分、皮肤或头发调理剂、阻燃剂、抗静电剂、味道调节剂、细胞、益生菌或其组合。
3.根据权利要求1所述的方法,其中所述微胶囊芯还含有抗微生物活性成分。
4.根据权利要求1所述的方法,其中所述微胶囊芯还含有抗感染剂。
5.根据权利要求1所述的方法,其中所述微胶囊芯还含有驱寄生虫剂。
6.根据权利要求1所述的方法,其中所述微胶囊芯还含有纳米至微米尺寸的无机固体。
7.根据权利要求1所述的方法,其中所述微胶囊芯还含有聚合物或弹性体颗粒。
8.根据权利要求1-7中任一项所述的方法,其中所述反应性基团是环氧基团、丙烯酰基基团、甲基丙烯酰基基团或醛基团。
9.根据权利要求1-7中任一项所述的方法,其中所述囊封聚合物是由多异氰酸酯和多胺的反应获得的聚脲聚合物。
10.根据权利要求9所述的方法,其中所述多胺是支化聚乙烯亚胺、线型聚乙烯亚胺、聚乙烯胺、胺改性的聚乙烯胺或氨端聚二甲基硅氧烷。
11.根据权利要求1-7中任一项所述的方法,其中所述囊封聚合物是三聚氰胺-甲醛聚合物、聚丙烯酸酯聚合物或二氧化硅聚合物。
12.根据权利要求1-7中任一项所述的方法,其中所述微胶囊浆料含有游离的支化聚乙烯亚胺,并且所述沉积剂与所述支化聚乙烯亚胺反应以形成改性的聚乙烯亚胺。
13.通过根据权利要求1-12中任一项所述的方法制备的微胶囊组合物。
14.根据权利要求13所述的微胶囊组合物,所述微胶囊组合物还包含游离沉积助剂,所述游离沉积助剂选自由以下各项组成的组:聚季铵盐-4、聚季铵盐-5、聚季铵盐-6、聚季铵盐-7、聚季铵盐-10、聚季铵盐-16、聚季铵盐-22、聚季铵盐-24、聚季铵盐-28、聚季铵盐-39、聚季铵盐-44、聚季铵盐-46、聚季铵盐-47、聚季铵盐-53、聚季铵盐-55、聚季铵盐-67、聚季铵盐-68、聚季铵盐-69、聚季铵盐-73、聚季铵盐-74、聚季铵盐-77、聚季铵盐-78、聚季铵盐-79、聚季铵盐-80、聚季铵盐-81、聚季铵盐-82、聚季铵盐-86、聚季铵盐-88、聚季铵盐-101、聚乙烯胺、聚乙烯亚胺、聚乙烯胺和乙烯甲酰胺共聚物及其组合。
15.一种表面改性的微胶囊,所述表面改性的微胶囊包含微胶囊芯和囊封所述微胶囊芯的微胶囊壁,
其中
所述微胶囊芯含有香精,
所述微胶囊壁由聚脲聚合物形成并且具有内表面和外表面,
所述内表面与所述微胶囊芯接触,
所述外表面具有各自经由共价键连接至所述外表面的一个或多个沉积基团,并且
所述沉积基团含有缩水甘油基三甲基铵部分、N-(2-(2-氧代咪唑烷-1-基)乙基)甲基丙烯酰胺部分、N-(2-(2-氧代咪唑烷-1-基)乙基)丙烯酰胺部分、N-(3,4-二羟基苯乙基)甲基丙烯酰胺部分、3,4-二羟基苯甲醛部分、[3-(甲基丙烯酰基氨基)丙基]三甲基氯化铵部分或(3-丙烯酰胺基丙基)三甲基铵部分。
16.根据权利要求15所述的表面改性的微胶囊,其中所述微胶囊的尺寸为0.1微米至1000微米;并且所述聚脲聚合物是支化聚乙烯亚胺和多异氰酸酯的反应产物。
17.根据权利要求16所述的表面改性的微胶囊,其中所述多异氰酸酯是六亚甲基二异氰酸酯的三聚体、异佛尔酮二异氰酸酯的三聚体、六亚甲基二异氰酸酯的缩二脲、甲苯二异氰酸酯的聚异氰脲酸酯、甲苯二异氰酸酯的三羟甲基丙烷加合物、苯二甲撑二异氰酸酯的三羟甲基丙烷加合物或其组合。
18.根据权利要求15-17中任一项所述的表面改性的微胶囊,所述表面改性的微胶囊还包含胶囊形成助剂,所述胶囊形成助剂选自由以下各项组成的组:聚乙烯醇、胺改性的聚乙烯胺、聚磺苯乙烯、羧甲基纤维素、多糖、季铵化多糖、氨端聚二甲基硅氧烷、萘磺酸盐缩合物盐、聚乙烯吡咯烷酮、乙烯吡咯烷酮和季铵化甲基丙烯酸二甲基氨基乙酯的共聚物及其组合。
19.根据权利要求15-17中任一项所述的表面改性的微胶囊,其中所述共价键是胺键(N-C)、亚胺键(N=C)、醚键(O-C)、酰胺键(-C(O)N-)或酯键(-C(O)O-)。
20.根据权利要求15-17中任一项所述的表面改性的微胶囊,其中所述微胶囊芯还含有香精前体、香料、恶臭中和剂、维生素、抗炎剂、杀真菌剂、麻醉剂、止痛剂、抗病毒剂、祛痘剂、皮肤光亮剂、驱昆虫剂、兽用驱避剂、软化剂、皮肤保湿剂、皱纹控制剂、UV防护剂、织物柔顺剂活性成分、硬表面清洁活性成分、皮肤或头发调理剂、阻燃剂、抗静电剂、味道调节剂、细胞、益生菌或其组合。
21.根据权利要求15-17中任一项所述的表面改性的微胶囊,其中所述微胶囊芯还含有抗微生物活性成分。
22.根据权利要求15-17中任一项所述的表面改性的微胶囊,其中所述微胶囊芯还含有抗感染剂。
23.根据权利要求15-17中任一项所述的表面改性的微胶囊,其中所述微胶囊芯还含有驱寄生虫剂。
24.根据权利要求15-17中任一项所述的表面改性的微胶囊,其中所述微胶囊芯还含有纳米至微米尺寸的无机固体。
25.根据权利要求15-17中任一项所述的表面改性的微胶囊,其中所述微胶囊芯还含有聚合物或弹性体颗粒。
26.根据权利要求12所述的方法,其中所述改性的聚乙烯亚胺通过以下步骤制备:
(a)提供含有伯胺或仲胺基团的聚乙烯亚胺,
(b)提供具有反应性基团的沉积剂,以及
(c)在所述伯胺或仲胺基团和所述反应性基团之间形成共价键以将所述沉积剂接枝到所述聚乙烯亚胺,
其中所述沉积剂是缩水甘油基三甲基铵盐、N-(2-(2-氧代咪唑烷-1-基)乙基)甲基丙烯酰胺、N-(2-(2-氧代咪唑烷-1-基)乙基)丙烯酰胺、N-(3,4-二羟基苯乙基)甲基丙烯酰胺、3,4-二羟基苯甲醛、[3-(甲基丙烯酰基氨基)丙基]三甲基氯化铵、(3-丙烯酰胺基丙基)三甲基铵或其组合。
27.根据权利要求26所述的方法,其中所述反应性基团是环氧基团、丙烯酰基基团、甲基丙烯酰基基团或醛基团。
28.根据权利要求26或27所述的方法,其中所述聚乙烯亚胺是支化聚乙烯亚胺、线型聚乙烯亚胺或其组合。
29.通过根据权利要求26-28中任一项所述的方法制备的改性的聚乙烯亚胺。
30.根据权利要求29所述的改性的聚乙烯亚胺,所述改性的聚乙烯亚胺包含聚乙烯亚胺主链和沉积部分,其中所述沉积部分经由共价键连接至所述聚乙烯亚胺主链,并且所述沉积部分是缩水甘油基三甲基铵部分、N-(2-(2-氧代咪唑烷-1-基)乙基)甲基丙烯酰胺部分、N-(2-(2-氧代咪唑烷-1-基)乙基)丙烯酰胺部分、N-(3,4-二羟基苯乙基)甲基丙烯酰胺部分、3,4-二羟基苯甲醛部分、[3-(甲基丙烯酰基氨基)丙基]三甲基氯化铵部分或(3-丙烯酰胺基丙基)三甲基铵部分。
31.根据权利要求30所述的改性的聚乙烯亚胺,其中所述聚乙烯亚胺主链是支化聚乙烯亚胺主链。
32.一种微胶囊组合物,所述微胶囊组合物包含微胶囊和根据权利要求29-31中任一项所述的改性的聚乙烯亚胺。
33.一种消费品,所述消费品包含根据权利要求13-14和32中任一项所述的微胶囊组合物或根据权利要求15-25中任一项所述的表面改性的微胶囊,其中所述消费品选自由以下各项组成的组:化妆品制备物、通用清洁剂、口腔护理产品、个人护理产品、织物护理产品和除臭剂。
34.一种消费品,所述消费品包含根据权利要求13-14和32中任一项所述的微胶囊组合物或根据权利要求15-25中任一项所述的表面改性的微胶囊,其中所述消费品选自由以下各项组成的组:洗发剂、护发剂、头发清新剂、头发固定助剂、头发漂白剂、头发染料、肥皂、沐浴液、浴厕清洁剂、地板清洁剂、窗户清洁剂、浴巾、纸巾、尿布疹乳膏或护臀膏、婴儿爽身粉、尿不湿、围嘴、牙膏、漱口水、牙齿增白剂、义齿粘附剂、口香糖、口气清新剂、口腔可溶条、咀嚼糖、硬糖、洗手液、抗炎软膏、抗炎喷雾剂、牙线、牙刷、卫生棉塞、卫生巾、防晒乳液、防晒喷雾剂、基于蜡的除臭剂、二醇型除臭剂、皂型除臭剂、面部乳液、手部乳液、爽身粉、剃须膏、去角质磨砂膏、足霜、织物柔顺剂、织物清新剂、熨烫水、液体衣物洗涤剂、液体碗碟洗涤剂、增味剂、烘干纸、固体香料、粉末粉底、液体粉底、眼影、唇膏、淡香水产品、地毯除臭剂、蜡烛、房间除臭剂、消毒剂和止汗剂。
35.一种消费品,所述消费品包含根据权利要求13-14和32中任一项所述的微胶囊组合物或根据权利要求15-25中任一项所述的表面改性的微胶囊,其中所述消费品是一次性擦拭巾。
36.一种消费品,所述消费品包含根据权利要求13-14和32中任一项所述的微胶囊组合物或根据权利要求15-25中任一项所述的表面改性的微胶囊,其中所述消费品是婴儿擦拭巾。
37.一种消费品,所述消费品包含根据权利要求13-14和32中任一项所述的微胶囊组合物或根据权利要求15-25中任一项所述的表面改性的微胶囊,其中所述消费品是身体乳液。
38.一种消费品,所述消费品包含根据权利要求13-14和32中任一项所述的微胶囊组合物或根据权利要求15-25中任一项所述的表面改性的微胶囊,其中所述消费品是浸浴用品。
39.一种消费品,所述消费品包含根据权利要求13-14和32中任一项所述的微胶囊组合物或根据权利要求15-25中任一项所述的表面改性的微胶囊,其中所述消费品是面巾。
40.一种消费品,所述消费品包含根据权利要求13-14和32中任一项所述的微胶囊组合物或根据权利要求15-25中任一项所述的表面改性的微胶囊,其中所述消费品是清洁擦拭巾。
41.一种消费品,所述消费品包含根据权利要求13-14和32中任一项所述的微胶囊组合物或根据权利要求15-25中任一项所述的表面改性的微胶囊,其中所述消费品是自动碗碟洗涤剂。
42.一种消费品,所述消费品包含根据权利要求13-14和32中任一项所述的微胶囊组合物或根据权利要求15-25中任一项所述的表面改性的微胶囊,其中所述消费品是单位剂量片剂或胶囊。
43.一种消费品,所述消费品包含根据权利要求13-14和32中任一项所述的微胶囊组合物或根据权利要求15-25中任一项所述的表面改性的微胶囊,其中所述消费品是精制香精。
44.一种消费品,所述消费品包含根据权利要求13-14和32中任一项所述的微胶囊组合物或根据权利要求15-25中任一项所述的表面改性的微胶囊,其中所述消费品是滚抹式产品或气溶胶产品。
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Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
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Family Cites Families (14)
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US6849185B1 (en) * | 1999-05-14 | 2005-02-01 | Pall Corp | Charged membrane |
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US20060248665A1 (en) * | 2005-05-06 | 2006-11-09 | Pluyter Johan G L | Encapsulated fragrance materials and methods for making same |
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US20160090552A1 (en) * | 2014-09-25 | 2016-03-31 | The Procter & Gamble Company | Detergent compositions containing a polyetheramine and an anionic soil release polymer |
US20180015009A1 (en) * | 2015-12-30 | 2018-01-18 | International Flavors & Fragrances Inc. | Microcapsule compositions with improved deposition |
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US20180085291A1 (en) * | 2016-09-28 | 2018-03-29 | International Flavors & Fragrances Inc. | Microcapsule compositions containing amino silicone |
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-
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CN104888671A (zh) * | 2015-05-05 | 2015-09-09 | 华南理工大学 | 一种双壳层微胶囊及其制备方法及应用 |
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