CN112402593A - 一种缓解运动膝关节不适的凝胶制剂 - Google Patents
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Abstract
本发明属于运动营养领域,涉及一种缓解运动膝关节不适的凝胶制剂。该方法包括以下几个步骤:(1)海棠果提取液制备;(2)叶黄素酯、鱼鳞胶原二肽溶解;(3)油相制备;(4)水相制备;(5)水相、油相混合,涂布分装。本发明技术方案有效提取了海棠果中的功效成分,同时复配了叶黄素酯和鱼鳞胶原二肽,在减少乳酸堆积的同时,减少肌肉和关节处的炎症因子,从而达到缓解运动后关节不适的作用;进一步地,本发明技术方案利用凝胶制剂,在提高载药量的同时,能够减少传统贴敷制剂带来的过敏反应,更加适合长期使用。
Description
技术领域
本发明涉及运动营养领域,特别涉及一种缓解运动膝关节不适的凝胶制剂。
背景技术
随着人们健康意识的不断增加,越来越多的人选择在学习和工作之余进行跑步、健身等各式各样的运动来锻炼身体。然而,在很多情况下,由于缺乏系统的训练和有效的热身与运动后的拉伸放松,使得很多人在运动的过程中和运动后出现不同程度的膝关节不适症状,例如:膝关节酸胀、膝关节紧张、膝关节疼痛等。而这种膝关节不适症状势必会影响到随后的工作和日常生活。另一方面,由于快速的工作和生活节奏,导致有膝关节不适症状的人无法得到合理的休息,就会加剧这种不适症状,甚至会出现不可逆的膝关节疾病。
就目前而言,轻度的膝关节不适症状的人群往往会选择硬抗(即不采取任何措施,任由其自行恢复);中度和重度的人群会采用冷敷喷雾、药物喷雾和麝香贴膏等措施来缓解和改善膝关节不适。然而,不可否认的是:(1)冷敷喷雾属于物理措施,只能保证一时的缓解,无法长效久治;(2)药物喷雾和麝香贴膏尽管能取得良好的缓解和治疗效果,但是长期连续使用可能会引发皮肤过敏症状,且由于药性的原因,不适用于特殊人群(孕妇、生理期妇女等),并具有较大的气味,会影响到周围的人群。
发明内容
有鉴于此,本发明的目的在于提供一种缓解运动膝关节不适的凝胶制剂,该技术能够有效提取海棠果的功效成分,同时复配叶黄素酯和鱼鳞胶原二肽,在减少乳酸堆积的同时,减少肌肉和关节处的炎症因子,从而达到加速运动疲劳恢复的作用;进一步地,本发明技术方案利用凝胶制剂,在提高载药量的同时,能够减少传统贴敷制剂带来的过敏反应,更加适合长期使用。
为实现上述目的,本发明提供如下技术方案:
一种缓解运动膝关节不适的凝胶制剂,按重量份计由50份海棠果提取液、5份叶黄素酯、10份鱼鳞胶原二肽、14份聚丙烯酸钠、12份聚乙烯吡咯烷酮、1份甘羟铝、60份甘油、1份酒石酸和1份冰片组成。
该凝胶制剂的制备包括以下几个步骤:
步骤1、将新鲜的海棠果,采用粉碎机粉碎后,加入其重量10倍的20%的乙醇溶液,80℃条件下,回流提取4小时,得到海棠果粗提液;
步骤2、将步骤1中得到的海棠果粗提液通过葡聚糖凝胶柱分离,收集15分钟以后的过滤液,得海棠果提取液;
步骤3、取50份重量的步骤2中得到的海棠果提取液,依次加入5份重量的叶黄素酯和10份重量的鱼鳞胶原二肽,搅拌均匀,得海棠果-叶黄素酯-鱼鳞胶原二肽混合液,加入1份重量的冰片、1份重量的酒石酸和12份重量的聚乙烯吡咯烷酮,搅拌均匀,室温放置24小时,得到水相混合液;
步骤4、取60份重量的甘油,将14份重量的聚丙烯酸钠和1份重量的甘羟铝,搅拌均匀,得油相混合液;
步骤5、将步骤3中得到的水相混合液,边搅拌边加入到步骤4中得到的油相混合液中,混合均匀,得混合液,按照10g每份进行涂布分装,即得。
其中,
海棠果提取液中富含多酚和黄酮物质,配合叶黄素酯能够达到加速体内由于运动产生的乳酸分解,避免乳酸堆积;
进一步地,海棠果提取液、鱼鳞胶原二肽能有效清除膝关节组织的炎症因子,润滑膝关节组织,缓解运动产生的膝关节僵硬、疼痛等不适症状。
最后,冰片能够带来一定程度的清凉感,能够给膝关节以物理冰敷来缓解不适。
本发明具有以下优点及有益效果:
(1)相比于现有技术产品,该方法针对运动产生的膝关节不适,通过海棠果提取液、叶黄素酯、鱼鳞胶原二肽和冰片的协同作用来减少运动后的乳酸堆积,消除膝关节组织的炎症因子,辅以物理冰敷,由表至里地缓解膝关节不适症状。
(2)相比于现有技术产品,该方法以凝胶剂型来承载天然功效成分,作用温和,针对性更强,不易产生皮肤过敏,特殊人群也能使用,且没有异味。
具体实施例
本发明公开了一种缓解运动膝关节不适的凝胶制剂,本领域技术人员可以借鉴本文内容,适当改进参数实现。特别需要指出的是,所有类似的替换和改动对本领域技术人员来说是显而易见的,它们都被视为包括在本发明。本发明所述制剂已经通过较佳实施例进行了描述,相关人员明显能在不脱离本发明内容、精神和范围内对本文所述的方法和应用进行改动或适当变更与组合,来实现和应用本发明。
为更好地阐述本发明,以下将通过具体的实施例进行说明。
实施例1:
步骤1、将新鲜的海棠果,采用粉碎机粉碎后,加入其重量10倍的20%的乙醇溶液,80℃条件下,回流提取4小时,得到海棠果粗提液;
步骤2、将步骤1中得到的海棠果粗提液通过葡聚糖凝胶柱分离,收集15分钟以后的过滤液,得海棠果提取液;
步骤3、取500g的步骤2中得到的海棠果提取液,依次加入50g的叶黄素酯和100g的鱼鳞胶原二肽,搅拌均匀,得海棠果-叶黄素酯-鱼鳞胶原二肽混合液,加入10g的冰片、10g的酒石酸和120g的聚乙烯吡咯烷酮,搅拌均匀,室温放置24小时,得到水相混合液;
步骤4、取600g的甘油,将140g的聚丙烯酸钠和10g的甘羟铝,搅拌均匀,得油相混合液;
步骤5、将步骤3中得到的水相混合液,边搅拌边加入到步骤4中得到的油相混合液中,混合均匀,得混合液,按照10g每份进行涂布分装,即得。
实施例2:
选择30名具有膝关节不适症状的30-40岁的人群(15名男性和15名女性),按照如下方案进行人体试食实验:按照运动1天(慢跑5公里),休息4天的频率运动3次(不贴敷本发明技术方案的凝胶制剂);再按照运动1天(慢跑5公里),休息4天的频率运动3次(每天贴敷本发明技术方案的凝胶制剂10g)。记录膝关节不适的恢复周期和有效程度,结果如表1和表2所示:
表1膝关节不适恢复周期试验结果
未贴敷时的膝关节恢复周期(天) | 贴敷后的膝关节恢复周期(天) |
3.45±0.73 | 2.29±0.61<sup>*</sup> |
注:*,在α=0.05时,未贴敷时和贴敷时具有显著性差异。
表2膝关节不适恢复有效率试验结果
有效人数 | 无效人数 | 有效率(%) |
28 | 2 | 93.3 |
从表1和表2看出,本发明技术方案所得的凝胶制剂能够有效缓解运动膝关节不适。
以上所述仅是本发明的特定实施方式,应当指出,对于本技术领域的普通技术人员来说,在不脱离本发明原理的前提下,还可以做出若干改进和润饰,这些改进和润饰也应视为本发明的保护范围。
Claims (2)
1.一种缓解运动膝关节不适的凝胶制剂,其特征在于,所述凝胶制剂按重量份计由50份海棠果提取液、5份叶黄素酯、10份鱼鳞胶原二肽、14份聚丙烯酸钠、12份聚乙烯吡咯烷酮、1份甘羟铝、60份甘油、1份酒石酸和1份冰片组成。
2.根据权利要求1所述的凝胶制剂,其特征在于,所述凝胶制剂的制备包括以下几个步骤:
步骤1、将新鲜的海棠果,采用粉碎机粉碎后,加入其重量10倍的20%的乙醇溶液,80℃条件下,回流提取4小时,得到海棠果粗提液;
步骤2、将步骤1中得到的海棠果粗提液通过葡聚糖凝胶柱分离,收集15分钟以后的过滤液,得海棠果提取液;
步骤3、取50份重量的步骤2中得到的海棠果提取液,依次加入5份重量的叶黄素酯和10份重量的鱼鳞胶原二肽,搅拌均匀,得海棠果-叶黄素酯-鱼鳞胶原二肽混合液,加入1份重量的冰片、1份重量的酒石酸和12份重量的聚乙烯吡咯烷酮,搅拌均匀,室温放置24小时,得到水相混合液;
步骤4、取60份重量的甘油,将14份重量的聚丙烯酸钠和1份重量的甘羟铝,搅拌均匀,得油相混合液;
步骤5、将步骤3中得到的水相混合液,边搅拌边加入到步骤4中得到的油相混合液中,混合均匀,得混合液,按照10g每份进行涂布分装,即得。
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Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1998045241A2 (en) * | 1997-04-04 | 1998-10-15 | Henkel Corporation | Lutein esters having high bioavailability |
CN105029400A (zh) * | 2015-04-10 | 2015-11-11 | 劲膳美生物科技股份有限公司 | 类风湿关节炎医学配方食品 |
CN105919983A (zh) * | 2016-07-07 | 2016-09-07 | 中日友好医院 | 一种药物基质组合物及其制备方法和用途 |
-
2020
- 2020-10-22 CN CN202011138750.7A patent/CN112402593A/zh active Pending
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1998045241A2 (en) * | 1997-04-04 | 1998-10-15 | Henkel Corporation | Lutein esters having high bioavailability |
CN105029400A (zh) * | 2015-04-10 | 2015-11-11 | 劲膳美生物科技股份有限公司 | 类风湿关节炎医学配方食品 |
CN105919983A (zh) * | 2016-07-07 | 2016-09-07 | 中日友好医院 | 一种药物基质组合物及其制备方法和用途 |
Non-Patent Citations (1)
Title |
---|
姜锡瑞 等: "《中国人最爱吃的60种水果》", vol. 4, 中国中医药出版社, pages: 223 - 225 * |
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