CN112386545A - 一种白金茶萃漱口液及其制备方法 - Google Patents
一种白金茶萃漱口液及其制备方法 Download PDFInfo
- Publication number
- CN112386545A CN112386545A CN202011506887.3A CN202011506887A CN112386545A CN 112386545 A CN112386545 A CN 112386545A CN 202011506887 A CN202011506887 A CN 202011506887A CN 112386545 A CN112386545 A CN 112386545A
- Authority
- CN
- China
- Prior art keywords
- tea
- tea extract
- honeysuckle
- extract
- ethanol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000284 extract Substances 0.000 title claims abstract description 77
- 238000002360 preparation method Methods 0.000 title claims abstract description 23
- 241001122767 Theaceae Species 0.000 title 1
- 244000269722 Thea sinensis Species 0.000 claims abstract description 145
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 claims abstract description 64
- 241000205585 Aquilegia canadensis Species 0.000 claims abstract description 54
- 238000003756 stirring Methods 0.000 claims abstract description 53
- 239000002324 mouth wash Substances 0.000 claims abstract description 37
- 239000002994 raw material Substances 0.000 claims abstract description 37
- 241000213006 Angelica dahurica Species 0.000 claims abstract description 36
- 229940051866 mouthwash Drugs 0.000 claims abstract description 35
- 239000000463 material Substances 0.000 claims abstract description 33
- 239000007788 liquid Substances 0.000 claims abstract description 32
- 229910052697 platinum Inorganic materials 0.000 claims abstract description 32
- 238000001914 filtration Methods 0.000 claims abstract description 31
- 239000000469 ethanolic extract Substances 0.000 claims abstract description 29
- 238000002156 mixing Methods 0.000 claims abstract description 26
- 238000004140 cleaning Methods 0.000 claims abstract description 18
- 239000011259 mixed solution Substances 0.000 claims abstract description 18
- 238000001816 cooling Methods 0.000 claims abstract description 16
- 239000000203 mixture Substances 0.000 claims abstract description 10
- 238000004659 sterilization and disinfection Methods 0.000 claims abstract description 8
- 238000003860 storage Methods 0.000 claims abstract description 6
- 239000010938 white gold Substances 0.000 claims abstract description 6
- 229910000832 white gold Inorganic materials 0.000 claims abstract description 6
- 235000013616 tea Nutrition 0.000 claims description 134
- 239000000706 filtrate Substances 0.000 claims description 44
- 238000000605 extraction Methods 0.000 claims description 38
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 37
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 36
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 34
- PUZPDOWCWNUUKD-UHFFFAOYSA-M sodium fluoride Chemical compound [F-].[Na+] PUZPDOWCWNUUKD-UHFFFAOYSA-M 0.000 claims description 26
- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 claims description 19
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 claims description 19
- 229940041616 menthol Drugs 0.000 claims description 19
- 238000005303 weighing Methods 0.000 claims description 15
- 239000000243 solution Substances 0.000 claims description 14
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims description 13
- 239000004378 Glycyrrhizin Substances 0.000 claims description 13
- BIVBRWYINDPWKA-VLQRKCJKSA-L Glycyrrhizinate dipotassium Chemical compound [K+].[K+].O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@H]1CC[C@]2(C)[C@H]3C(=O)C=C4[C@@H]5C[C@](C)(CC[C@@]5(CC[C@@]4(C)[C@]3(C)CC[C@H]2C1(C)C)C)C(O)=O)C([O-])=O)[C@@H]1O[C@H](C([O-])=O)[C@@H](O)[C@H](O)[C@H]1O BIVBRWYINDPWKA-VLQRKCJKSA-L 0.000 claims description 13
- 239000004359 castor oil Substances 0.000 claims description 13
- 235000019438 castor oil Nutrition 0.000 claims description 13
- 229940101029 dipotassium glycyrrhizinate Drugs 0.000 claims description 13
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 claims description 13
- LPLVUJXQOOQHMX-UHFFFAOYSA-N glycyrrhetinic acid glycoside Natural products C1CC(C2C(C3(CCC4(C)CCC(C)(CC4C3=CC2=O)C(O)=O)C)(C)CC2)(C)C2C(C)(C)C1OC1OC(C(O)=O)C(O)C(O)C1OC1OC(C(O)=O)C(O)C(O)C1O LPLVUJXQOOQHMX-UHFFFAOYSA-N 0.000 claims description 13
- 229960004949 glycyrrhizic acid Drugs 0.000 claims description 13
- UYRUBYNTXSDKQT-UHFFFAOYSA-N glycyrrhizic acid Natural products CC1(C)C(CCC2(C)C1CCC3(C)C2C(=O)C=C4C5CC(C)(CCC5(C)CCC34C)C(=O)O)OC6OC(C(O)C(O)C6OC7OC(O)C(O)C(O)C7C(=O)O)C(=O)O UYRUBYNTXSDKQT-UHFFFAOYSA-N 0.000 claims description 13
- 235000019410 glycyrrhizin Nutrition 0.000 claims description 13
- LPLVUJXQOOQHMX-QWBHMCJMSA-N glycyrrhizinic acid Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@@H]1C([C@H]2[C@]([C@@H]3[C@@]([C@@]4(CC[C@@]5(C)CC[C@@](C)(C[C@H]5C4=CC3=O)C(O)=O)C)(C)CC2)(C)CC1)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O LPLVUJXQOOQHMX-QWBHMCJMSA-N 0.000 claims description 13
- 235000013024 sodium fluoride Nutrition 0.000 claims description 13
- 239000011775 sodium fluoride Substances 0.000 claims description 13
- 239000000600 sorbitol Substances 0.000 claims description 13
- IDGUHHHQCWSQLU-UHFFFAOYSA-N ethanol;hydrate Chemical compound O.CCO IDGUHHHQCWSQLU-UHFFFAOYSA-N 0.000 claims description 12
- 239000012535 impurity Substances 0.000 claims description 10
- 239000011148 porous material Substances 0.000 claims description 10
- 238000012216 screening Methods 0.000 claims description 10
- 238000002791 soaking Methods 0.000 claims description 10
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims description 6
- 238000000034 method Methods 0.000 claims description 6
- 239000007864 aqueous solution Substances 0.000 claims description 5
- 238000009835 boiling Methods 0.000 claims description 5
- 238000010438 heat treatment Methods 0.000 claims description 5
- 239000008236 heating water Substances 0.000 claims description 5
- 238000004806 packaging method and process Methods 0.000 claims description 5
- 150000003333 secondary alcohols Chemical class 0.000 claims description 5
- 229960000414 sodium fluoride Drugs 0.000 claims description 5
- 239000006228 supernatant Substances 0.000 claims description 5
- 235000006468 Thea sinensis Nutrition 0.000 claims description 4
- 238000002481 ethanol extraction Methods 0.000 claims description 3
- 235000009569 green tea Nutrition 0.000 claims description 3
- 235000020334 white tea Nutrition 0.000 claims description 3
- 235000020338 yellow tea Nutrition 0.000 claims description 3
- 235000020279 black tea Nutrition 0.000 claims description 2
- 235000019225 fermented tea Nutrition 0.000 claims description 2
- 235000020333 oolong tea Nutrition 0.000 claims description 2
- 230000000694 effects Effects 0.000 description 13
- 150000008442 polyphenolic compounds Chemical class 0.000 description 11
- 235000013824 polyphenols Nutrition 0.000 description 11
- 235000011187 glycerol Nutrition 0.000 description 10
- 208000002193 Pain Diseases 0.000 description 8
- 230000001276 controlling effect Effects 0.000 description 8
- 230000036407 pain Effects 0.000 description 8
- 208000025865 Ulcer Diseases 0.000 description 5
- 239000000126 substance Substances 0.000 description 5
- 235000019640 taste Nutrition 0.000 description 5
- 231100000397 ulcer Toxicity 0.000 description 5
- 241000894006 Bacteria Species 0.000 description 4
- 239000003814 drug Substances 0.000 description 4
- 210000002200 mouth mucosa Anatomy 0.000 description 4
- 241000193830 Bacillus <bacterium> Species 0.000 description 3
- 206010006326 Breath odour Diseases 0.000 description 3
- 208000032139 Halitosis Diseases 0.000 description 3
- 206010061218 Inflammation Diseases 0.000 description 3
- 208000007117 Oral Ulcer Diseases 0.000 description 3
- 208000002399 aphthous stomatitis Diseases 0.000 description 3
- 230000035876 healing Effects 0.000 description 3
- 230000004054 inflammatory process Effects 0.000 description 3
- 230000007774 longterm Effects 0.000 description 3
- 210000000214 mouth Anatomy 0.000 description 3
- LSHVYAFMTMFKBA-TZIWHRDSSA-N (-)-epicatechin-3-O-gallate Chemical compound O([C@@H]1CC2=C(O)C=C(C=C2O[C@@H]1C=1C=C(O)C(O)=CC=1)O)C(=O)C1=CC(O)=C(O)C(O)=C1 LSHVYAFMTMFKBA-TZIWHRDSSA-N 0.000 description 2
- 206010018291 Gingival swelling Diseases 0.000 description 2
- 208000032843 Hemorrhage Diseases 0.000 description 2
- 206010037660 Pyrexia Diseases 0.000 description 2
- 239000004480 active ingredient Substances 0.000 description 2
- 230000000844 anti-bacterial effect Effects 0.000 description 2
- 230000003064 anti-oxidating effect Effects 0.000 description 2
- 239000000022 bacteriostatic agent Substances 0.000 description 2
- 230000000740 bleeding effect Effects 0.000 description 2
- 230000001680 brushing effect Effects 0.000 description 2
- 229940126678 chinese medicines Drugs 0.000 description 2
- 208000002925 dental caries Diseases 0.000 description 2
- 238000004332 deodorization Methods 0.000 description 2
- 230000001877 deodorizing effect Effects 0.000 description 2
- 230000003467 diminishing effect Effects 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 235000013305 food Nutrition 0.000 description 2
- 230000036541 health Effects 0.000 description 2
- 230000002401 inhibitory effect Effects 0.000 description 2
- 230000002265 prevention Effects 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 230000001954 sterilising effect Effects 0.000 description 2
- 230000008961 swelling Effects 0.000 description 2
- 229940126673 western medicines Drugs 0.000 description 2
- CWVRJTMFETXNAD-FWCWNIRPSA-N 3-O-Caffeoylquinic acid Natural products O[C@H]1[C@@H](O)C[C@@](O)(C(O)=O)C[C@H]1OC(=O)\C=C\C1=CC=C(O)C(O)=C1 CWVRJTMFETXNAD-FWCWNIRPSA-N 0.000 description 1
- 206010002198 Anaphylactic reaction Diseases 0.000 description 1
- 244000063299 Bacillus subtilis Species 0.000 description 1
- 235000014469 Bacillus subtilis Nutrition 0.000 description 1
- PZIRUHCJZBGLDY-UHFFFAOYSA-N Caffeoylquinic acid Natural products CC(CCC(=O)C(C)C1C(=O)CC2C3CC(O)C4CC(O)CCC4(C)C3CCC12C)C(=O)O PZIRUHCJZBGLDY-UHFFFAOYSA-N 0.000 description 1
- GHXZTYHSJHQHIJ-UHFFFAOYSA-N Chlorhexidine Chemical compound C=1C=C(Cl)C=CC=1NC(N)=NC(N)=NCCCCCCN=C(N)N=C(N)NC1=CC=C(Cl)C=C1 GHXZTYHSJHQHIJ-UHFFFAOYSA-N 0.000 description 1
- 208000001840 Dandruff Diseases 0.000 description 1
- 206010059866 Drug resistance Diseases 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 241000588724 Escherichia coli Species 0.000 description 1
- 206010018276 Gingival bleeding Diseases 0.000 description 1
- 206010019233 Headaches Diseases 0.000 description 1
- 208000003445 Mouth Neoplasms Diseases 0.000 description 1
- 206010028748 Nasal obstruction Diseases 0.000 description 1
- CWVRJTMFETXNAD-KLZCAUPSSA-N Neochlorogenin-saeure Natural products O[C@H]1C[C@@](O)(C[C@@H](OC(=O)C=Cc2ccc(O)c(O)c2)[C@@H]1O)C(=O)O CWVRJTMFETXNAD-KLZCAUPSSA-N 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 206010031009 Oral pain Diseases 0.000 description 1
- 208000000114 Pain Threshold Diseases 0.000 description 1
- 208000003251 Pruritus Diseases 0.000 description 1
- 208000019155 Radiation injury Diseases 0.000 description 1
- 241000191940 Staphylococcus Species 0.000 description 1
- 241000191967 Staphylococcus aureus Species 0.000 description 1
- 241000194017 Streptococcus Species 0.000 description 1
- 208000033809 Suppuration Diseases 0.000 description 1
- 208000037386 Typhoid Diseases 0.000 description 1
- 241000607626 Vibrio cholerae Species 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 206010048038 Wound infection Diseases 0.000 description 1
- 208000005946 Xerostomia Diseases 0.000 description 1
- 206010000269 abscess Diseases 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 208000003455 anaphylaxis Diseases 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 230000003266 anti-allergic effect Effects 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- 235000006708 antioxidants Nutrition 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 230000003385 bacteriostatic effect Effects 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 235000013361 beverage Nutrition 0.000 description 1
- 235000019658 bitter taste Nutrition 0.000 description 1
- 208000034158 bleeding Diseases 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 238000002512 chemotherapy Methods 0.000 description 1
- 229940112822 chewing gum Drugs 0.000 description 1
- 235000015218 chewing gum Nutrition 0.000 description 1
- 229960003260 chlorhexidine Drugs 0.000 description 1
- 239000000460 chlorine Substances 0.000 description 1
- 229910052801 chlorine Inorganic materials 0.000 description 1
- 125000001309 chloro group Chemical group Cl* 0.000 description 1
- CWVRJTMFETXNAD-JUHZACGLSA-N chlorogenic acid Chemical compound O[C@@H]1[C@H](O)C[C@@](O)(C(O)=O)C[C@H]1OC(=O)\C=C\C1=CC=C(O)C(O)=C1 CWVRJTMFETXNAD-JUHZACGLSA-N 0.000 description 1
- 229940074393 chlorogenic acid Drugs 0.000 description 1
- FFQSDFBBSXGVKF-KHSQJDLVSA-N chlorogenic acid Natural products O[C@@H]1C[C@](O)(C[C@@H](CC(=O)C=Cc2ccc(O)c(O)c2)[C@@H]1O)C(=O)O FFQSDFBBSXGVKF-KHSQJDLVSA-N 0.000 description 1
- 235000001368 chlorogenic acid Nutrition 0.000 description 1
- BMRSEYFENKXDIS-KLZCAUPSSA-N cis-3-O-p-coumaroylquinic acid Natural products O[C@H]1C[C@@](O)(C[C@@H](OC(=O)C=Cc2ccc(O)cc2)[C@@H]1O)C(=O)O BMRSEYFENKXDIS-KLZCAUPSSA-N 0.000 description 1
- 230000001112 coagulating effect Effects 0.000 description 1
- 238000004891 communication Methods 0.000 description 1
- 235000009508 confectionery Nutrition 0.000 description 1
- 239000002826 coolant Substances 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 239000000645 desinfectant Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 206010013781 dry mouth Diseases 0.000 description 1
- 208000001848 dysentery Diseases 0.000 description 1
- 230000009982 effect on human Effects 0.000 description 1
- 230000001804 emulsifying effect Effects 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 238000004299 exfoliation Methods 0.000 description 1
- 210000004709 eyebrow Anatomy 0.000 description 1
- 235000003599 food sweetener Nutrition 0.000 description 1
- 208000007565 gingivitis Diseases 0.000 description 1
- 229930182470 glycoside Natural products 0.000 description 1
- 231100000869 headache Toxicity 0.000 description 1
- 230000002949 hemolytic effect Effects 0.000 description 1
- 239000003906 humectant Substances 0.000 description 1
- 230000036737 immune function Effects 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 230000007803 itching Effects 0.000 description 1
- MWDZOUNAPSSOEL-UHFFFAOYSA-N kaempferol Natural products OC1=C(C(=O)c2cc(O)cc(O)c2O1)c3ccc(O)cc3 MWDZOUNAPSSOEL-UHFFFAOYSA-N 0.000 description 1
- 230000002147 killing effect Effects 0.000 description 1
- 208000012987 lip and oral cavity carcinoma Diseases 0.000 description 1
- 230000003859 lipid peroxidation Effects 0.000 description 1
- LRDGATPGVJTWLJ-UHFFFAOYSA-N luteolin Natural products OC1=CC(O)=CC(C=2OC3=CC(O)=CC(O)=C3C(=O)C=2)=C1 LRDGATPGVJTWLJ-UHFFFAOYSA-N 0.000 description 1
- 235000009498 luteolin Nutrition 0.000 description 1
- -1 luteolin glycoside Chemical class 0.000 description 1
- 210000001165 lymph node Anatomy 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 229960000282 metronidazole Drugs 0.000 description 1
- VAOCPAMSLUNLGC-UHFFFAOYSA-N metronidazole Chemical compound CC1=NC=C([N+]([O-])=O)N1CCO VAOCPAMSLUNLGC-UHFFFAOYSA-N 0.000 description 1
- 210000004877 mucosa Anatomy 0.000 description 1
- 210000004400 mucous membrane Anatomy 0.000 description 1
- 230000035772 mutation Effects 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 230000037040 pain threshold Effects 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 238000010926 purge Methods 0.000 description 1
- 230000008929 regeneration Effects 0.000 description 1
- 238000011069 regeneration method Methods 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- 229940092665 tea leaf extract Drugs 0.000 description 1
- 208000004371 toothache Diseases 0.000 description 1
- 229940034610 toothpaste Drugs 0.000 description 1
- 239000000606 toothpaste Substances 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 201000008297 typhoid fever Diseases 0.000 description 1
- 229940118696 vibrio cholerae Drugs 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/35—Caprifoliaceae (Honeysuckle family)
- A61K36/355—Lonicera (honeysuckle)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/82—Theaceae (Tea family), e.g. camellia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/20—Halogens; Compounds thereof
- A61K8/21—Fluorides; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/41—Amines
- A61K8/416—Quaternary ammonium compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/63—Steroids; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/06—Free radical scavengers or antioxidants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/805—Corresponding aspects not provided for by any of codes A61K2800/81 - A61K2800/95
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Birds (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Alternative & Traditional Medicine (AREA)
- Medical Informatics (AREA)
- Emergency Medicine (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Inorganic Chemistry (AREA)
- Biochemistry (AREA)
- Toxicology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Cosmetics (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
本发明公开一种白金茶萃漱口液,包括基础原料混合液、白芷金银花乙醇萃提液、茶叶萃提液,其质量比为(15~35):(5~30):(35~80)。本发明还公开了一种白金茶萃漱口液的制备方法,包括:(1)、配制白芷金银花乙醇萃提液;(2)配制基础原料混合液;(3)、配制茶叶萃提液;(4)、分别按照配方量将基础原料混合液、茶叶萃提液加入到配液罐B中,边加入物料边搅拌,使二者充分混匀;(5)、向配液罐B中加入配方量的白芷金银花乙醇萃提液,至完全混合均匀后,边搅拌边降温至常温停止搅拌,经100~300目滤网过滤后,存储于清洗消毒后的储液罐中常温保存72~120小时,即得到白金茶萃漱口液。
Description
技术领域
本发明属于口腔护理领域,具体涉及一种白金茶萃漱口液及其制备方法。
背景技术
随着生活水平的提高,人们越来越关注口腔的健康。口腔溃疡、牙龈肿痛、龋齿、口臭等口腔问题逐渐成为人们面对面清新交流的阻碍。为此,每天仅有的早晚两次刷牙已远远不能满足人们对口气清新的需求。增加刷牙次数,嚼口香糖等解决措施虽然能达到一定效果,但是不够方便,不够理想。相应的漱口水便成为广泛关注的对象,它方便,快捷,见效快。
目前市场上的漱口液分为以下两类:第一类为添加化学药物的消毒杀菌剂,如氯己定漱口液,口感苦涩,且长期使用将会对人体产生副作用,易导致牙齿变黄;如添加甲硝唑等抗生素的漱口液,长期使用细菌会产生相应的耐药性,也可能会引发其他的口腔问题,如口腔黏膜脱落甚至过敏反应。另一类为添加了抑菌成分的漱口液,如添加化学成分的漱口液,长期使有会引起口腔味觉改变,对舌头有灼烧感;添加中药成分的漱口液,中药提取过程复杂繁琐,且口感欠佳;添加了酒精成分的漱口液,口味单一难闻,口感不好,影响用户体验,且会受室温的影响产生不适症状。
发明内容
为了解决上述现有技术的不足,本发明提供一种白金茶萃漱口液及其制备方法,本发明公开的白金茶萃漱口液具有清新口气的作用,茶叶中富含的主要功效成分茶多酚(tea polyphenols,TP)可以抑制口腔细菌、除口臭作用、促进溃疡愈合、抗口腔辐射伤害、调节免疫功能、抗口腔癌。茶多酚为植物性抗氧化剂,能清除过量自由基,增强口腔黏膜的抵抗力和代谢作用,保护口腔黏膜的完整性、促进口腔黏膜溃疡愈合;同时茶多酚可增强微血管弹性、韧性,防止出血,改善血液循环,减轻疼痛,抑制口腔炎症发生;此外茶多酚还可有效抑制溃疡面上细菌生长繁殖,增强黏膜的再生能力,从而加快溃疡面愈合速度。用茶多酚含漱液进行化疗后口腔护理,口腔疼痛、出血、溃疡、颌下淋巴结肿大的临床缓解率显著提高;同样用茶多酚漱口液进行口腔颌面外科围术期患者口腔护理,结果显示牙龈出血、伤口感染、口腔溃疡、口干、口臭、咽痛发生率显著降低。这些功效使茶类漱口液成为局部防治口腔黏膜病的理想选择。
本发明充分利用茶叶香气清新、杀菌、除臭、防龋齿和抗氧化等多重功能,结合白芷、金银花和口腔清洁防护常用日化成分,中西结合、相辅相成,制备一种能长期使用而不产生副作用的,保持口气清新、维护口腔健康的日用品,以解决现有漱口液的安全和味道问题。
技术方案:一种白金茶萃漱口液,包括基础原料混合液、白芷金银花乙醇萃提液、茶叶萃提液,其中:
基础原料混合液:白芷金银花乙醇萃提液:茶叶萃提液的质量比为(15~35):(5~30):(35~80);
所述基础原料混合液以质量百分比计,包括:甘油1~20%、山梨醇1~8%、PEG-40氢化蓖麻油0.1~3%、西比氯胺0.01~0.6%、甘草酸二钾0.01~0.15%、甘草酸苷0.02~0.5%、氟化钠0.01~0.25%,余量为水。
进一步地,所述白芷金银花乙醇萃提液以质量百分比计,包括:白芷2~10%,金银花2~10%,薄荷脑0.02~0.4%,余量为35%~75%V/V的乙醇水溶液。
进一步地,所述茶叶萃提液以质量百分比计,包括:茶叶1~4%、余量为水,其中:
所述茶叶是绿茶、白茶、黄茶、乌龙茶、红茶、黑茶中的任何一种或几种复配而成。
进一步地,所述基础原料混合液:所述白芷金银花乙醇萃提液:所述茶叶萃提液的质量比为25:10:65。
进一步地,所述基础原料混合液以质量百分比计,包括:甘油12%、山梨醇8%、EG-40氢化蓖麻油2%、西比氯胺0.3%、甘草酸二钾0.05%、甘草酸苷0.2%、氟化钠0.02%、余量为水。
进一步地,所述白芷金银花乙醇萃提液以质量百分比计,包括:白芷2%、金银花5%、薄荷脑0.12%,余量为46%V/V的乙醇水溶液。
进一步地,所述茶叶萃提液以质量百分比计,包括:茶叶3%、水97%。
一种白金茶萃漱口液的制备方法,包括如下步骤:
(1)、配制白芷金银花乙醇萃提液
(11)、分别称取配方量的金银花和白芷,经挑拣筛除杂质并清理干净后,置于萃提容器中;
(12)、第一次醇提:
向提取容器中加8~20倍体积的45%~85%V/V乙醇水溶液,在45~65℃条件下浸渍12~72小时,滤过,收集滤液;
(13)、第二次醇提:
向提取容器中加入6~12倍体积的45%~85%V/V乙醇水溶液,在45~65℃条件下浸渍6~48小时,滤过,收集滤液;
(14)、合并步骤(12)和步骤(13)得到的滤液;
(15)、将步骤(14)合并后的滤液冷却至1~5℃,静置24~120小时,采集上清液,经0.2~1.0微米孔径的滤材过滤,收集滤液;
(16)、将步骤(15)得到的滤液置于浓缩罐中,在55~75℃、-0.1MPa~-0.05MPa条件下减压浓缩至乙醇含量35%~75%V/V后,在其中加入配方量的薄荷脑,充分搅拌使薄荷脑完全溶解,得到白芷金银花乙醇萃提液;
(2)配制基础原料混合液:
称取配方量的水加至配料罐A中,将配料罐A中的水加热至75~85℃后保持温度不变,边搅拌边加入配方量的甘油、山梨醇、PEG-40氢化蓖麻油、西比氯胺、甘草酸二钾、甘草酸苷和氟化钠,待全部物料完全溶解后,保持温度不变继续搅拌15~30分钟,即得基础原料混合液;
(3)、配制茶叶萃提液:
称取配方量的茶叶,经挑拣筛除杂质并清理干净后,置于萃提容器中,取12倍茶叶质量的水加热至沸腾后注入盛放有茶叶的萃提容器中,在80~98℃条件下萃提5~10分钟,经200~300目滤网过滤,收集滤液;之后再用12倍茶叶质量的沸水如上所述重复萃提茶叶1~7次,合并所有滤液即得到茶叶萃提液;
(4)、分别按照配方量将上述步骤(2)配制的基础原料混合液、步骤(3)配制的茶叶萃提液加入到控温在75~80℃的配液罐B中,边加入物料边搅拌,搅拌转速控制在10~30转/分钟,使二者充分混匀,边搅拌边降温至45~55℃;
(5)、向配液罐B中加入配方量的步骤(1)所得白芷金银花乙醇萃提液,边加入物料边搅拌,搅拌转速控制在10~30转/分钟,至完全混合均匀后,边搅拌边降温至常温停止搅拌,经100~300目滤网过滤后,存储于清洗消毒后的储液罐中常温保存72~120小时,即得到白金茶萃漱口液。
进一步地,还包括步骤(6):将步骤(5)得到的白金茶萃漱口液经0.2~1.0微米孔径的滤材过滤后,在洁净环境下进行封装,制成独立包装的白金茶萃漱口液。
茶叶:主要功效性成分是多酚类物质,又称茶多酚、茶鞣质或茶单宁。茶多酚具有较强的抗氧化作用,能有效清除有害自由基,阻断脂质过氧化过程,提高人体内酶的活性,从而起到抗突变、抗癌症的作用。除抗氧化作用外,茶多酚还具有抑菌作用,能够通过凝结蛋白质的收敛作用,与菌体蛋白质结合而致细菌死亡,对葡萄球菌、大肠杆菌、枯草杆菌等具有较强的抑制作用。茶多酚还可以吸附食品中的异味,因此具有一定的除臭作用。
金银花:主要功效是清热解毒。现代研究证明,金银花含有绿原酸、木犀草素苷等药理活性成分,具有很好的抗菌消炎的作用,且抗菌谱广,对伤寒杆菌、副伤寒杆菌、金黄色葡萄球菌、溶血性链球菌、痢疾杆菌、霍乱弧菌等有明显的抑制杀灭作用。此外,金银花还具有抗病毒、消炎、泻火解热、调节免疫等多种功能。
白芷:色白、性温、味辛、微苦,具有散风除湿、通窍止痛、消肿排脓、治疗牙龈炎及其红肿疼痛的作用,在临床上广泛用于感冒头疼、眉棱骨疼、鼻塞、鼻渊、牙痛、白带、脓肿等病症,具有较好的疗效。白芷内有效的脂溶性成分可使痛阈值明显提高,可以达到解热镇痛的效果。本产品以金银花和白芷萃取物为有效添加成分,以达到抑菌杀菌、除臭止痛的效果。
薄荷脑是清凉剂,也可用作牙膏、饮料和糖果等的赋香剂。作用于皮肤或粘膜,有清凉止痒作用。
所述基础原料混合液中甘油和山梨醇是保湿剂,EG-40氢化蓖麻油是增乳剂,西比氯胺是含氯乳化抑菌剂,甘草酸二钾是抗敏抑菌剂,甘草酸苷是甜味剂,氟化钠是氟离子的供体,共同起到清洁洗涤、除臭去屑、消炎抑菌、清新爽口、防龋齿的作用。
本发明公开的一种白金茶萃漱口液及其制备方法具有以下有益效果:
以茶叶萃取液为主要主体,添加药食同源活性成分与适宜的口腔护理日化材料,中西结合、相辅相成,能够有效治理口腔溃疡、减缓牙龈肿痛,有去火、清新口气的效果,能较为长期的使用而不产生副作用。
具体实施方式:
下面对本发明的具体实施方式详细说明。
具体实施例1
一种白金茶萃漱口液,包括基础原料混合液、白芷金银花乙醇萃提液、茶叶萃提液,其中:
基础原料混合液:白芷金银花乙醇萃提液:茶叶萃提液的质量比为25:10:65;
所述基础原料混合液以质量百分比计,包括:甘油12%、山梨醇8%、EG-40氢化蓖麻油2%、西比氯胺0.3%、甘草酸二钾0.05%、甘草酸苷0.2%、氟化钠0.02%、余量为水。
进一步地,所述白芷金银花乙醇萃提液以质量百分比计,包括:白芷2%,金银花5%,薄荷脑0.12%,余量为46%V/V的乙醇水溶液。
进一步地,所述茶叶萃提液以质量百分比计,包括:茶叶3%、余量为水,其中:
所述茶叶是绿茶。
一种白金茶萃漱口液的制备方法,包括如下步骤:
(1)、配制白芷金银花乙醇萃提液
(11)、分别称取配方量的金银花和白芷,经挑拣筛除杂质并清理干净后,置于萃提容器中;
(12)、第一次醇提:
向提取容器中加10倍体积的65%V/V乙醇水溶液,在55℃条件下浸渍36小时,滤过,收集滤液;
(13)、第二次醇提:
向提取容器中加入10倍体积的65%V/V乙醇水溶液,在55℃条件下浸渍24小时,滤过,收集滤液;
(14)、合并步骤(12)和步骤(13)得到的滤液;
(15)、将步骤(14)合并后的滤液冷却至3℃,静置60小时,采集上清液,经0.5微米孔径的滤材过滤,收集滤液;
(16)、将步骤(15)得到的滤液置于浓缩罐中,在65℃、-0.08MPa条件下减压浓缩至乙醇含量46%V/V后,在其中加入配方量的薄荷脑,充分搅拌使薄荷脑完全溶解,得到白芷金银花乙醇萃提液;
(2)配制基础原料混合液:
称取配方量的水加至配料罐A中,将配料罐A中的水加热至80℃后保持温度不变,边搅拌边加入配方量的甘油、山梨醇、PEG-40氢化蓖麻油、西比氯胺、甘草酸二钾、甘草酸苷和氟化钠,待全部物料完全溶解后,保持温度不变继续搅拌20分钟,即得基础原料混合液;
(3)、配制茶叶萃提液:
称取配方量的茶叶,经挑拣筛除杂质并清理干净后,置于萃提容器中,取12倍茶叶质量的水加热至沸腾后注入盛放有茶叶的萃提容器中,在90℃条件下萃提8分钟,经250目滤网过滤,收集滤液;之后再用12倍茶叶质量的沸水如上所述重复萃提茶叶2次,合并所有三次的滤液即得到茶叶萃提液;
(4)、分别按照配方量将上述步骤(2)配制的基础原料混合液、步骤(3)配制的茶叶萃提液加入到控温在77℃的配液罐B中,边加入物料边搅拌,搅拌转速控制在20转/分钟,使二者充分混匀,边搅拌边降温至50℃;
(5)、向配液罐B中加入配方量的步骤(1)所得白芷金银花乙醇萃提液,边加入物料边搅拌,搅拌转速控制在20转/分钟,至完全混合均匀后,边搅拌边降温至常温停止搅拌,经200目滤网过滤后,存储于清洗消毒后的储液罐中常温保存96小时,即得到白金茶萃漱口液。
进一步地,还包括步骤(6):将步骤(5)得到的白金茶萃漱口液经0.5微米孔径的滤材过滤后,在洁净环境下进行封装,制成独立包装的白金茶萃漱口液。
具体实施例2
一种白金茶萃漱口液,包括基础原料混合液、白芷金银花乙醇萃提液、茶叶萃提液,其中:
基础原料混合液:白芷金银花乙醇萃提液:茶叶萃提液的质量比为15:5:35;
所述基础原料混合液以质量百分比计,包括:甘油1%、山梨醇1%、PEG-40氢化蓖麻油0.1%、西比氯胺0.01%、甘草酸二钾0.01%、甘草酸苷0.02%、氟化钠0.01%,余量为水。
进一步地,所述白芷金银花乙醇萃提液以质量百分比计,包括:白芷6%,金银花2%,薄荷脑0.02%,余量为35%V/V的乙醇水溶液。
进一步地,所述茶叶萃提液以质量百分比计,包括:茶叶1%、余量为水,其中:
所述茶叶是白茶。
一种白金茶萃漱口液的制备方法,包括如下步骤:
(1)、配制白芷金银花乙醇萃提液
(11)、分别称取配方量的金银花和白芷,经挑拣筛除杂质并清理干净后,置于萃提容器中;
(12)、第一次醇提:
向提取容器中加8倍体积的45%V/V乙醇水溶液,在45℃条件下浸渍12小时,滤过,收集滤液;
(13)、第二次醇提:
向提取容器中加入6倍体积的45%V/V乙醇水溶液,在45℃条件下浸渍6小时,滤过,收集滤液;
(14)、合并步骤(12)和步骤(13)得到的滤液;
(15)、将步骤(14)合并后的滤液冷却至1℃,静置24小时,采集上清液,经0.2微米孔径的滤材过滤,收集滤液;
(16)、将步骤(15)得到的滤液置于浓缩罐中,在55℃、-0.05MPa条件下减压浓缩至乙醇含量35%V/V后,在其中加入配方量的薄荷脑,充分搅拌使薄荷脑完全溶解,得到白芷金银花乙醇萃提液;
(2)配制基础原料混合液:
称取配方量的水加至配料罐A中,将配料罐A中的水加热至75℃后保持温度不变,边搅拌边加入配方量的甘油、山梨醇、PEG-40氢化蓖麻油、西比氯胺、甘草酸二钾、甘草酸苷和氟化钠,待全部物料完全溶解后,保持温度不变继续搅拌15分钟,即得基础原料混合液;
(3)、配制茶叶萃提液:
称取配方量的茶叶,经挑拣筛除杂质并清理干净后,置于萃提容器中,取12倍茶叶质量的水加热至沸腾后注入盛放有茶叶的萃提容器中,在80℃条件下萃提5分钟,经200目滤网过滤,收集滤液;之后再用12倍茶叶质量的沸水如上所述重复萃提茶叶7次,合并所有8次的滤液即得到茶叶萃提液;
(4)、分别按照配方量将上述步骤(2)配制的基础原料混合液、步骤(3)配制的茶叶萃提液加入到控温在75℃的配液罐B中,边加入物料边搅拌,搅拌转速控制在10转/分钟,使二者充分混匀,边搅拌边降温至45℃;
(5)、向配液罐B中加入配方量的步骤(1)所得白芷金银花乙醇萃提液,边加入物料边搅拌,搅拌转速控制在10转/分钟,至完全混合均匀后,边搅拌边降温至常温停止搅拌,经100目滤网过滤后,存储于清洗消毒后的储液罐中常温保存72小时,即得到白金茶萃漱口液。
进一步地,还包括步骤(6):将步骤(5)得到的白金茶萃漱口液经0.2微米孔径的滤材过滤后,在洁净环境下进行封装,制成独立包装的白金茶萃漱口液。
具体实施例3
一种白金茶萃漱口液,包括基础原料混合液、白芷金银花乙醇萃提液、茶叶萃提液,其中:
基础原料混合液:白芷金银花乙醇萃提液:茶叶萃提液的质量比为35:30:80;
所述基础原料混合液以质量百分比计,包括:甘油20%、山梨醇6%、PEG-40氢化蓖麻油3%、西比氯胺0.6%、甘草酸二钾0.15%、甘草酸苷0.5%、氟化钠0.25%,余量为水。
进一步地,所述白芷金银花乙醇萃提液以质量百分比计,包括:白芷10%,金银花10%,薄荷脑0.4%,余量为75%V/V的乙醇水溶液。
进一步地,所述茶叶萃提液以质量百分比计,包括:茶叶4%、余量为水,其中:
所述茶叶是黄茶。
一种白金茶萃漱口液的制备方法,包括如下步骤:
(1)、配制白芷金银花乙醇萃提液
(11)、分别称取配方量的金银花和白芷,经挑拣筛除杂质并清理干净后,置于萃提容器中;
(12)、第一次醇提:
向提取容器中加20倍体积的85%V/V乙醇水溶液,在65℃条件下浸渍72小时,滤过,收集滤液;
(13)、第二次醇提:
向提取容器中加入12倍体积的85%V/V乙醇水溶液,在65℃条件下浸渍48小时,滤过,收集滤液;
(14)、合并步骤(12)和步骤(13)得到的滤液;
(15)、将步骤(14)合并后的滤液冷却至5℃,静置120小时,采集上清液,经1.0微米孔径的滤材过滤,收集滤液;
(16)、将步骤(15)得到的滤液置于浓缩罐中,在75℃、-0.1MPa条件下减压浓缩至乙醇含量75%V/V后,在其中加入配方量的薄荷脑,充分搅拌使薄荷脑完全溶解,得到白芷金银花乙醇萃提液;
(2)配制基础原料混合液:
称取配方量的水加至配料罐A中,将配料罐A中的水加热至85℃后保持温度不变,边搅拌边加入配方量的甘油、山梨醇、PEG-40氢化蓖麻油、西比氯胺、甘草酸二钾、甘草酸苷和氟化钠,待全部物料完全溶解后,保持温度不变继续搅拌30分钟,即得基础原料混合液;
(3)、配制茶叶萃提液:
称取配方量的茶叶,经挑拣筛除杂质并清理干净后,置于萃提容器中,取12倍茶叶质量的水加热至沸腾后注入盛放有茶叶的萃提容器中,在98℃条件下萃提10分钟,经300目滤网过滤,收集滤液;之后再用12倍茶叶质量的沸水如上所述重复萃提茶叶1次,合并所有2次的滤液即得到茶叶萃提液;
(4)、分别按照配方量将上述步骤(2)配制的基础原料混合液、步骤(3)配制的茶叶萃提液加入到控温在80℃的配液罐B中,边加入物料边搅拌,搅拌转速控制在30转/分钟,使二者充分混匀,边搅拌边降温至55℃;
(5)、向配液罐B中加入配方量的步骤(1)所得白芷金银花乙醇萃提液,边加入物料边搅拌,搅拌转速控制在30转/分钟,至完全混合均匀后,边搅拌边降温至常温停止搅拌,经300目滤网过滤后,存储于清洗消毒后的储液罐中常温保存120小时,即得到白金茶萃漱口液。
进一步地,还包括步骤(6):将步骤(5)得到的白金茶萃漱口液经1.0微米孔径的滤材过滤后,在洁净环境下进行封装,制成独立包装的白金茶萃漱口液。
具体实施例4-10
与具体实施例1大致相同,区别仅仅在于所使用的的茶叶不同:
上面对本发明的实施方式做了详细说明。但是本发明并不限于上述实施方式,在所属技术领域普通技术人员所具备的知识范围内,还可以在不脱离本发明宗旨的前提下做出各种变化。
Claims (9)
1.一种白金茶萃漱口液,其特征在于,包括基础原料混合液、白芷金银花乙醇萃提液、茶叶萃提液,其中:
基础原料混合液:白芷金银花乙醇萃提液:茶叶萃提液的质量比为(15~35):(5~30):(35~80);
所述基础原料混合液以质量百分比计,包括:甘油1~20%、山梨醇1~8%、PEG-40氢化蓖麻油0.1~3%、西比氯胺0.01~0.6%、甘草酸二钾0.01~0.15%、甘草酸苷0.02~0.5%、氟化钠0.01~0.25%,余量为水。
2.如权利要求1所述的一种白金茶萃漱口液,其特征在于,所述白芷金银花乙醇萃提液以质量百分比计,包括:白芷2~10%,金银花2~10%,薄荷脑0.02~0.4%,余量为35%~75%V/V的乙醇水溶液。
3.如权利要求2所述的一种白金茶萃漱口液,其特征在于,所述茶叶萃提液以质量百分比计,包括:茶叶1~4%、余量为水,其中:
所述茶叶是绿茶、白茶、黄茶、乌龙茶、红茶、黑茶中的任何一种或几种复配而成。
4.如权利要求1所述的一种白金茶萃漱口液,其特征在于,所述基础原料混合液:所述白芷金银花乙醇萃提液:所述茶叶萃提液的质量比为25:10:65。
5.如权利要求1所述的一种白金茶萃漱口液,其特征在于,所述基础原料混合液以质量百分比计,包括:甘油12%、山梨醇8%、EG-40氢化蓖麻油2%、西比氯胺0.3%、甘草酸二钾0.05%、甘草酸苷0.2%、薄荷脑0.12%、氟化钠0.02%、余量为水。
6.如权利要求2所述的一种白金茶萃漱口液,其特征在于,所述白芷金银花乙醇萃提液以质量百分比计,包括:白芷2%、金银花5%、薄荷脑0.12%,余量为46%V/V的乙醇水溶液。
7.如权利要求3所述的一种白金茶萃漱口液,其特征在于,所述茶叶萃提液以质量百分比计,包括:茶叶3%、水97%。
8.一种白金茶萃漱口液的制备方法,其特征在于,包括如下步骤:
(1)、配制白芷金银花乙醇萃提液:
(11)、分别称取配方量的金银花和白芷,经挑拣筛除杂质并清理干净后,置于萃提容器中;
(12)、第一次醇提:
向提取容器中加8~20倍体积的45%~85%V/V乙醇水溶液,在45~65℃条件下浸渍12~72小时,滤过,收集滤液;
(13)、第二次醇提:
向提取容器中加入6~12倍体积的45%~85%V/V乙醇水溶液,在45~65℃条件下浸渍6~48小时,滤过,收集滤液;
(14)、合并步骤(12)和步骤(13)得到的滤液;
(15)、将步骤(14)合并后的滤液冷却至1~5℃,静置24~120小时,采集上清液,经0.2~1.0微米孔径的滤材过滤,收集滤液;
(16)、将步骤(15)得到的滤液置于浓缩罐中,在55~75℃、-0.1MPa~-0.05MPa条件下减压浓缩至乙醇含量35%~75%V/V后,在其中加入配方量的薄荷脑,充分搅拌使薄荷脑完全溶解,得到白芷金银花乙醇萃提液;
(2)配制基础原料混合液:
称取配方量的水加至配料罐A中,将配料罐A中的水加热至75~85℃后保持温度不变,边搅拌边加入配方量的甘油、山梨醇、PEG-40氢化蓖麻油、西比氯胺、甘草酸二钾、甘草酸苷和氟化钠,待全部物料完全溶解后,保持温度不变继续搅拌15~30分钟,即得基础原料混合液;
(3)、配制茶叶萃提液:
称取配方量的茶叶,经挑拣筛除杂质并清理干净后,置于萃提容器中,取12倍茶叶质量的水加热至沸腾后注入盛放有茶叶的萃提容器中,在80~98℃条件下萃提5~10分钟,经200~300目滤网过滤,收集滤液;之后再用12倍茶叶质量的沸水如上所述重复萃提茶叶1~7次,合并所有滤液即得到茶叶萃提液;
(4)、分别按照配方量将上述步骤(2)配制的基础原料混合液、步骤(3)配制的茶叶萃提液加入到控温在75~80℃的配液罐B中,边加入物料边搅拌,搅拌转速控制在10~30转/分钟,使二者充分混匀,边搅拌边降温至45~55℃;
(5)、向配液罐B中加入配方量的步骤(1)所得白芷金银花乙醇萃提液,边加入物料边搅拌,搅拌转速控制在10~30转/分钟,至完全混合均匀后,边搅拌边降温至常温停止搅拌,经100~300目滤网过滤后,存储于清洗消毒后的储液罐中常温保存72~120小时,即得到白金茶萃漱口液。
9.如权利要求8所述的一种白金茶萃漱口液的制备方法,其特征在于,还包括步骤(6):将步骤(5)得到的白金茶萃漱口液经0.2~1.0微米孔径的滤材过滤后,在洁净环境下进行封装,制成独立包装的白金茶萃漱口液。
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN202011506887.3A CN112386545A (zh) | 2020-12-18 | 2020-12-18 | 一种白金茶萃漱口液及其制备方法 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN202011506887.3A CN112386545A (zh) | 2020-12-18 | 2020-12-18 | 一种白金茶萃漱口液及其制备方法 |
Publications (1)
Publication Number | Publication Date |
---|---|
CN112386545A true CN112386545A (zh) | 2021-02-23 |
Family
ID=74625345
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN202011506887.3A Pending CN112386545A (zh) | 2020-12-18 | 2020-12-18 | 一种白金茶萃漱口液及其制备方法 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN112386545A (zh) |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103655419A (zh) * | 2013-12-04 | 2014-03-26 | 何小刚 | 新型草本漱口水及其制备方法 |
CN106074341A (zh) * | 2016-07-11 | 2016-11-09 | 周晗生 | 便携式口腔护理液 |
CN106265423A (zh) * | 2016-08-23 | 2017-01-04 | 广州立白企业集团有限公司 | 具有清火消痛作用的口腔护理组合物 |
CN106619284A (zh) * | 2016-12-08 | 2017-05-10 | 西安中天生物医药有限公司 | 一种用于口腔抑菌和口气清新的重要漱口水及其配制方法 |
CN111919934A (zh) * | 2020-09-17 | 2020-11-13 | 傅松涛 | 一种用于降三高保护心血管的红花苏心茶及其制备方法 |
-
2020
- 2020-12-18 CN CN202011506887.3A patent/CN112386545A/zh active Pending
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103655419A (zh) * | 2013-12-04 | 2014-03-26 | 何小刚 | 新型草本漱口水及其制备方法 |
CN106074341A (zh) * | 2016-07-11 | 2016-11-09 | 周晗生 | 便携式口腔护理液 |
CN106265423A (zh) * | 2016-08-23 | 2017-01-04 | 广州立白企业集团有限公司 | 具有清火消痛作用的口腔护理组合物 |
CN106619284A (zh) * | 2016-12-08 | 2017-05-10 | 西安中天生物医药有限公司 | 一种用于口腔抑菌和口气清新的重要漱口水及其配制方法 |
CN111919934A (zh) * | 2020-09-17 | 2020-11-13 | 傅松涛 | 一种用于降三高保护心血管的红花苏心茶及其制备方法 |
Non-Patent Citations (1)
Title |
---|
梁润等: "中药漱口液治疗复发性口腔溃疡临床疗效观察", 《湖北中医药大学学报》 * |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US6811769B2 (en) | Oral composition, method of making the oral composition and oral hygiene method in japanese and chinese herbal remedy | |
WO2015034252A1 (ko) | 한방추출물과 프로폴리스가 첨가된 치약 | |
KR101481371B1 (ko) | 울금을 함유한 치약 조성물 및 그 제조 방법 | |
CN108186441A (zh) | 一种止血抗过敏的复合草本漱口水及其制备方法 | |
CN104013547A (zh) | 一种止血亮白清新口气型牙膏及其制备方法 | |
CN108014070A (zh) | 止血消炎的可视化蜂胶酸性漱口水及其制备方法 | |
CN111450038A (zh) | 一种抑制口腔幽门螺杆菌牙膏 | |
CN109125144A (zh) | 一种预防口腔溃疡、抑制幽门螺旋杆菌的牙膏及其制法 | |
CN108272862A (zh) | 一种蒲地蓝口腔喷雾剂及其制备方法 | |
CN110946804B (zh) | 一种预防龋齿和口腔溃疡的漱口水及其制备方法 | |
CN101181208B (zh) | 一种含天然抗菌素的漱口液及其制备方法 | |
WO2016010284A1 (ko) | 울금을 함유한 치약 조성물 및 그 제조 방법 | |
CN107982192A (zh) | 一种有效除烟味的草本护理漱口水 | |
KR102364900B1 (ko) | 도꼬마리 및 작두콩 추출물을 유효성분으로 포함하는 구강내 염증 개선용 치약조성물 및 그 제조방법 | |
CN103599182A (zh) | 中药组合物及其制备方法、口腔清洁护理用品及其制备方法 | |
KR102171798B1 (ko) | 천연 추출물을 포함하는 구취 감소 및 치주질환 예방용 조성물 및 이의 제조 방법 | |
CN106038334A (zh) | 含有苦丁茶提取物的抑菌祛味牙膏 | |
CN110151915A (zh) | 一种蜂胶口腔护理液及其制备方法 | |
CN112386545A (zh) | 一种白金茶萃漱口液及其制备方法 | |
CN111743790B (zh) | 一种低粘度的海盐口腔护理漱口水 | |
CN112972355A (zh) | 一种中药牙膏及其制备方法 | |
KR101910716B1 (ko) | 녹차 함유 구강세척제 | |
CN113491660B (zh) | 一种中草药漱口水及其制备方法 | |
CN112336678B (zh) | 一种清新口气的牙膏 | |
CN113181102B (zh) | 一种具有滋润口腔清新口气功能的漱口水及其制备方法 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PB01 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
RJ01 | Rejection of invention patent application after publication |
Application publication date: 20210223 |
|
RJ01 | Rejection of invention patent application after publication |