CN112384238A - 减少瘢痕形成的局部黏着激酶抑制剂的受控水凝胶递送 - Google Patents

减少瘢痕形成的局部黏着激酶抑制剂的受控水凝胶递送 Download PDF

Info

Publication number
CN112384238A
CN112384238A CN201980045397.7A CN201980045397A CN112384238A CN 112384238 A CN112384238 A CN 112384238A CN 201980045397 A CN201980045397 A CN 201980045397A CN 112384238 A CN112384238 A CN 112384238A
Authority
CN
China
Prior art keywords
composition
hydrogel
fak
faki
inhibitor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201980045397.7A
Other languages
English (en)
Chinese (zh)
Inventor
G·C·古特尼尔
权蝉萤
M·I·纳齐尔·阿赫麦德
J·拉贾达斯
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Leland Stanford Junior University
Original Assignee
Leland Stanford Junior University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Leland Stanford Junior University filed Critical Leland Stanford Junior University
Publication of CN112384238A publication Critical patent/CN112384238A/zh
Pending legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/56—Porous materials, e.g. foams or sponges
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
    • A61L15/225—Mixtures of macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42—Use of materials characterised by their function or physical properties
    • A61L15/425—Porous materials, e.g. foams or sponges
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42—Use of materials characterised by their function or physical properties
    • A61L15/44—Medicaments
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42—Use of materials characterised by their function or physical properties
    • A61L15/60—Liquid-swellable gel-forming materials, e.g. super-absorbents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
    • A61L27/24—Collagen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/52—Hydrogels or hydrocolloids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/204—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials with nitrogen-containing functional groups, e.g. aminoxides, nitriles, guanidines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/416—Anti-neoplastic or anti-proliferative or anti-restenosis or anti-angiogenic agents, e.g. paclitaxel, sirolimus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
    • A61L2300/602—Type of release, e.g. controlled, sustained, slow
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/18—Materials or treatment for tissue regeneration for hair reconstruction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/34—Materials or treatment for tissue regeneration for soft tissue reconstruction

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Transplantation (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Dermatology (AREA)
  • Dispersion Chemistry (AREA)
  • Materials Engineering (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Materials For Medical Uses (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN201980045397.7A 2018-05-16 2019-05-16 减少瘢痕形成的局部黏着激酶抑制剂的受控水凝胶递送 Pending CN112384238A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201862672513P 2018-05-16 2018-05-16
US62/672,513 2018-05-16
US201962848515P 2019-05-15 2019-05-15
US62/848,515 2019-05-15
PCT/US2019/032697 WO2019222520A1 (en) 2018-05-16 2019-05-16 Controlled hydrogel delivery of focal adhesion kinase inhibitor for decreased scar formation

Publications (1)

Publication Number Publication Date
CN112384238A true CN112384238A (zh) 2021-02-19

Family

ID=68540759

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201980045397.7A Pending CN112384238A (zh) 2018-05-16 2019-05-16 减少瘢痕形成的局部黏着激酶抑制剂的受控水凝胶递送

Country Status (8)

Country Link
US (1) US12178940B2 (enExample)
EP (1) EP3793589B1 (enExample)
JP (2) JP7585045B2 (enExample)
CN (1) CN112384238A (enExample)
AU (2) AU2019269608B2 (enExample)
CA (1) CA3100352A1 (enExample)
ES (1) ES2980620T3 (enExample)
WO (1) WO2019222520A1 (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2019269608B2 (en) * 2018-05-16 2025-04-03 The Board Of Trustees Of The Leland Stanford Junior University Controlled hydrogel delivery of focal adhesion kinase inhibitor for decreased scar formation
EP4126223A4 (en) * 2020-03-26 2024-04-24 The Board of Trustees of the Leland Stanford Junior University Methods for tissue regeneration and kits therefor
WO2022191812A1 (en) * 2021-03-08 2022-09-15 National Cheng Kung University Method of facilitating wound-induced hair follicle neogenesis, tissue regeneration and reducing wound stiffness
AU2022318736A1 (en) * 2021-07-30 2023-11-16 The Board Of Trustees Of The Leland Stanford Junior University Mechanotransduction disruption mediation in skin grafting methods and compositions for use in practicing the same
EP4661921A1 (en) * 2023-02-24 2025-12-17 Tautona Group Research And Development Company, L.L.C. Wound dressing assembly
WO2025122385A1 (en) * 2023-12-08 2025-06-12 Purinomia Biotech, Inc. Methods and compositions for reducing scar formation and treating dermatological wounds

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110305745A1 (en) * 2010-03-04 2011-12-15 Gurtner Geoffrey C Pollulan regenerative matrix
US20130165463A1 (en) * 2011-12-09 2013-06-27 The Board Of Trustees Of The Leland Stanford Junior University Inhibition of focal adhesion kinase for control of scar tissue formation

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3973420B2 (ja) 2001-12-28 2007-09-12 ライフケア技研株式会社 創傷被覆材の製造方法
WO2005060550A2 (en) * 2003-12-11 2005-07-07 Teikoku Pharma Usa, Inc. Methods and compositions for treating skin wounds
KR101499080B1 (ko) 2006-08-03 2015-03-06 더 보드 오브 트러스티스 오브 더 리랜드 스탠포드 쥬니어 유니버시티 반흔 및/또는 켈로이드의 치료 또는 예방을 위한 디바이스 및 붕대와 그것을 위한 방법 및 키트
JP5904949B2 (ja) 2010-11-12 2016-04-20 日産化学工業株式会社 脂質ペプチド型ゲル化剤と高分子化合物とを含有するゲルシート
US20140072613A1 (en) 2012-09-10 2014-03-13 Cynthia Lander Compositions and Methods for Treating Cutaneous Scarring
AU2019269608B2 (en) * 2018-05-16 2025-04-03 The Board Of Trustees Of The Leland Stanford Junior University Controlled hydrogel delivery of focal adhesion kinase inhibitor for decreased scar formation

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110305745A1 (en) * 2010-03-04 2011-12-15 Gurtner Geoffrey C Pollulan regenerative matrix
US20130165463A1 (en) * 2011-12-09 2013-06-27 The Board Of Trustees Of The Leland Stanford Junior University Inhibition of focal adhesion kinase for control of scar tissue formation

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
KUN MA等: "Controlled Delivery of a Focal Adhesion Kinase Inhibitor Results in Accelerated Wound Closure with Decreased Scar Formation", 《JOURNAL OF INVESTIGATIVE DERMATOLOGY》, vol. 138, 15 May 2018 (2018-05-15) *
徐荣祥主编: "《中国烧伤创疡学（烧伤湿性医疗技术局部治疗部分）》", 31 May 1997, 中国烧伤创疡科技中心《中国烧伤创疡杂志社》, pages: 139 *

Also Published As

Publication number Publication date
AU2019269608B2 (en) 2025-04-03
AU2025205095A1 (en) 2025-07-24
CA3100352A1 (en) 2019-11-21
AU2019269608A1 (en) 2020-11-26
JP7585045B2 (ja) 2024-11-18
ES2980620T3 (es) 2024-10-02
JP2024123220A (ja) 2024-09-10
WO2019222520A1 (en) 2019-11-21
US20210361833A1 (en) 2021-11-25
EP3793589A4 (en) 2022-01-26
EP3793589B1 (en) 2024-05-01
US12178940B2 (en) 2024-12-31
JP2021524849A (ja) 2021-09-16
EP3793589A1 (en) 2021-03-24

Similar Documents

Publication Publication Date Title
CN112384238A (zh) 减少瘢痕形成的局部黏着激酶抑制剂的受控水凝胶递送
JP6042815B2 (ja) 生物医学的応用のためのアルギン酸塩及びヒアルロン酸を用いる抗癒着性バリア膜
JP2022174265A (ja) 羊膜粉末ならびに創傷治癒および組織工学構築物におけるその使用
JP6538139B2 (ja) 癒着防止のためのハイドロゲル膜
Ma et al. Controlled delivery of a focal adhesion kinase inhibitor results in accelerated wound closure with decreased scar formation
KR102049124B1 (ko) 교차-결합된 히알루론산의 섬조 및 이들의 이용 방법
US20120039959A1 (en) Anti-Adhesion Alginate Barrier of Variable Absorbance
JP2000511512A (ja) 酸化ポリサッカライドで架橋したゼラチンを含有する新規医薬
JP2018525360A (ja) 創傷治癒、組織工学、及び再生医療のための組成物及び方法における使用のための大豆由来の生物活性ペプチド
EP3305339B1 (en) Method for manufacturing collagen film using ultraviolet light, collagen film manufactured by using same, and biomaterial prepared using collagen film
Alka et al. Polymeric gel scaffolds and biomimetic environments for wound healing
Zhao et al. Biodegradable multifunctional hyaluronic acid hydrogel microneedle band-aids for accelerating skin wound healing
WO2008125872A1 (en) Wif-1 for accelerating wound healing
JP2008543922A (ja) 生体吸収性ヒドロゲル
JP2022505767A (ja) 機能的な創傷治療ドレッシング材
EP1543846A1 (fr) Hydrogel biorésorbable réticulé à base d'albumine
KR20160142758A (ko) 자외선을 이용한 콜라겐 필름의 제조방법, 이를 이용하여 제조된 콜라겐 필름 및 콜라겐 필름을 이용하여 제조된 생체재료
KR20250050595A (ko) 창상을 치료하기 위한 상피세포성장인자 마이크로 비드 시스템 및 그의 제조 방법
CN118892571A (zh) 一种多功效的可降解组织粘合贴片及其制备方法和应用
US20100056452A1 (en) Angiogenesis-promoting substrate

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination