CN112370568A - Liquid dressing and preparation method thereof - Google Patents
Liquid dressing and preparation method thereof Download PDFInfo
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- CN112370568A CN112370568A CN202011376046.5A CN202011376046A CN112370568A CN 112370568 A CN112370568 A CN 112370568A CN 202011376046 A CN202011376046 A CN 202011376046A CN 112370568 A CN112370568 A CN 112370568A
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- liquid dressing
- octenidine
- forming agent
- wound healing
- film forming
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0061—Use of materials characterised by their function or physical properties
- A61L26/0066—Medicaments; Biocides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
- A61L26/0014—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
- A61L26/0023—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0057—Ingredients of undetermined constitution or reaction products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/204—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials with nitrogen-containing functional groups, e.g. aminoxides, nitriles, guanidines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/23—Carbohydrates
- A61L2300/232—Monosaccharides, disaccharides, polysaccharides, lipopolysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/30—Compounds of undetermined constitution extracted from natural sources, e.g. Aloe Vera
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/412—Tissue-regenerating or healing or proliferative agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/412—Tissue-regenerating or healing or proliferative agents
- A61L2300/414—Growth factors
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Materials Engineering (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention discloses a liquid dressing and a preparation method thereof, and the formula comprises the following components in percentage by mass: 0.1-8% of film forming agent, 0.01-0.03% of octenidine, 0.2-10% of humectant, 0.1-5% of substance for promoting wound healing, 0.1-5% of alginate oligosaccharide and 80.89-86.88% of water; the octenidine and the brown algae oligosaccharide have a synergistic effect, so that the antibacterial ability can be improved and the wound healing can be facilitated when the octenidine and the brown algae oligosaccharide are used together, the liquid dressing can be free from external interference through the improvement of the whole formula, the bacteria can be effectively inhibited, the wound healing can be promoted, and a continuous moisturizing environment is provided for the skin.
Description
Technical Field
The invention relates to the field of medical materials, in particular to a liquid dressing and a preparation method thereof.
Background
The liquid dressing is a broad-spectrum bactericide which can act on the body surface and the lacuna mucosa of a human body, and can be applied to skin treatment such as debridement, irrigation, moistening of acute and chronic wounds, ulcer, incision, abrasion, burn and the like.
The prior liquid dressing formula mainly adopts antibacterial agents comprising: povidone iodine, chlorhexidine, silver ions, and the like; however, the dressing prepared by the formula has a short bacteriostasis time; the bacteriostatic effect is easily influenced by interferents (such as blood and mucus); the drug resistance is easy to generate, the skin can not be well protected, a continuous moisturizing environment is provided, and the wound is not healed; the market needs a liquid dressing which is not interfered by the outside, can effectively inhibit bacteria, promotes wound healing and provides a continuous moisture-preserving environment for the skin, and the invention solves the problems.
Disclosure of Invention
In order to solve the defects of the prior art, the invention aims to provide a liquid dressing and a preparation method thereof, and the liquid dressing can be free from external interference, effectively inhibit bacteria, promote wound healing and provide a continuous moisturizing environment for skin by improving a formula.
In order to achieve the above object, the present invention adopts the following technical solutions:
a liquid dressing comprises the following components in percentage by mass: 0.1-8% of film forming agent, 0.01-0.03% of octenidine, 0.2-10% of humectant, 0.1-5% of substance for promoting wound healing, 0.1-5% of alginate oligosaccharide and 80.89-86.88% of water.
The liquid dressing comprises the following film forming agents: polyvinyl alcohol, sodium carboxymethyl cellulose.
The liquid dressing, the humectant comprises: sodium hyaluronate, glycerol.
The liquid dressing comprises the following materials for promoting wound healing: centella asiatica extract, allantoin, epidermal growth factor.
A preparation method of a liquid dressing comprises the following steps:
the materials are prepared in accordance with the formulation,
the formula comprises the following components in percentage by mass: 0.1-8% of film forming agent, 0.01-0.03% of octenidine, 0.2-10% of humectant, 0.1-5% of substance for promoting wound healing, 0.1-5% of alginate oligosaccharide and 80.89-86.88% of water;
slowly adding the film forming agent into water, and then heating to 30-90 ℃ until the film forming agent is completely dissolved;
adding octenidine into the solution, controlling the temperature at 30-50 ℃, and stirring for 20-30 minutes;
adding the humectant into the solution, controlling the temperature to be 20-40 ℃, and stirring for 10-20 minutes;
adding the substance for promoting wound healing into the solution, controlling the temperature to be 20-40 ℃, and stirring for 10-20 minutes;
adding the alginate oligosaccharide into the solution, controlling the temperature at 20-40 ℃, and stirring for 20-30 minutes to obtain the liquid dressing.
In the preparation method of the liquid dressing, the film-forming agent comprises: polyvinyl alcohol, sodium carboxymethyl cellulose.
In the preparation method of the liquid dressing, the humectant comprises: sodium hyaluronate, glycerol.
In the preparation method of the liquid dressing, the wound healing promoting substance comprises: centella asiatica extract, allantoin, epidermal growth factor.
The invention has the advantages that:
the octenidine and the brown alginate oligosaccharide have a synergistic effect, and when the octenidine and the brown alginate oligosaccharide are used together, the bacteriostatic ability can be improved, and the wound healing is facilitated;
the film forming agent of the invention is prepared from the following materials: polyvinyl alcohol and sodium carboxymethyl cellulose can form a layer of good physical barrier on the surface of a wound;
the humectant is added into the formula, so that a moist environment can be formed on the wound surface, and the wound healing is further assisted;
the invention adds the wound healing promoting substance, and is further beneficial to wound healing.
Detailed Description
The present invention will be described in detail with reference to the following embodiments.
Samples 1-3 and comparative samples 1-2 were prepared using the formulations of the following examples and the following preparation methods.
Example 1: polyvinyl alcohol 0.1%, octenidine 0.02%, sodium hyaluronate 8%, centella asiatica extract 3%, alginate oligosaccharide 2%, and water 86.88%;
example 2: polyvinyl alcohol 4%, octenidine 0.01%, glycerin 10%, centella asiatica extract 0.1%, alginate oligosaccharides 5%, water 80.89%;
example 3: 8% of polyvinyl alcohol, 0.03% of octenidine, 0.2% of glycerol, 5% of allantoin, 0.1% of alginate oligosaccharide and 86.67% of water;
comparative example 1: 4% of polyvinyl alcohol, 10% of glycerol, 0.1% of centella asiatica extract, 5% of alginate oligosaccharides and 80.9% of water;
comparative example 2: polyvinyl alcohol 4%, octenidine 0.01%, glycerin 10%, centella asiatica extract 0.1%, water 85.89%;
the method comprises the following steps:
firstly, slowly adding a film-forming agent into water, and then heating to 30-90 ℃ until the film-forming agent is completely dissolved;
secondly, adding octenidine into the solution, controlling the temperature at 30-50 ℃, and stirring for 20-30 minutes;
thirdly, adding the humectant into the solution, controlling the temperature to be 20-40 ℃, and stirring for 10-20 minutes;
fourthly, adding the substance for promoting wound healing into the solution, controlling the temperature to be 20-40 ℃, and stirring for 10-20 minutes;
fifthly, adding the alginate oligosaccharides into the solution, controlling the temperature at 20-40 ℃, and stirring for 20-30 minutes to obtain the liquid dressing.
The obtained samples 1 to 3 and the comparative samples 1 to 2 were subjected to the following verification experiments:
experiment one: bacteriostatic experiments:
1. test instruments and materials
1.1 test apparatus
FA2004 electronic balance; an XFH-30CA electric heating type pressure steam sterilizing pot; BCC-1100112-X biological safety cabinet; SHP-80 biochemical incubator; XK96-A flash mixer.
1.2 culture Medium
Trypticase Soytone agar Medium (TSA), Sabouraud dextrose agar Medium (SDA)
1.3 strains: escherichia coli (CMCC), staphylococcus aureus ((CMCC), candida albicans (CMCC), pseudomonas aeruginosa (CMCC).
1.4 test article
The prepared liquid dressing for inhibiting bacteria and promoting healing has the specification of 25 ml/bottle. Sample 1, sample 2, sample 3, comparative sample 1, comparative sample 2
2 contents of the experiment
2.1 preparation of bacterial liquid
Taking the appropriate amountInoculating the plate culture of Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa and Candida albicans cultured at 34 deg.C for 24 hr into 1ml 0.9% sterile NaCl solution (hereinafter referred to as solvent), and further diluting with solvent by 100 times to obtain 5 × 105-5×106cfu/ml of bacterial solution for later use.
2.2 test methods: taking 4 bottles of 5ml of sample and 5ml of reference solution (sterile water), respectively, adding 100 μ l of the prepared bacterial solution dropwise into each sample and reference solution, mixing, timing, and allowing to act for 20 min. Diluting the affected bacterial liquid with sterile water by 10 times, respectively taking 0.25ml of diluted bacterial liquid, and uniformly coating on TSA (Escherichia coli, Pseudomonas aeruginosa and Staphylococcus aureus) or SDA (Candida albicans) plate. The TSA plate was incubated at 34 ℃ and the SDA plate at 25 ℃
And counting colonies and calculating the bacteriostasis rate after 2-3 days.
2.3 calculating the bacteriostasis rate
Bacteriostasis rate (contrast group-test article group)/contrast article group
2.4 the results are shown in Table 1:
TABLE 1
And (4) analyzing results: from table 1, it can be seen that sample 1, sample 2, and sample 3 all have better bacteriostatic effects, and sample 1, sample 2, and sample 3 have substantial progress in bacteriostatic effects compared to comparative sample 1 and comparative sample 2, so that the synergistic effect of the coordination experiment of octenidine and fucoidan oligosaccharide in bacteriostatic action can be demonstrated.
Experiment two: test of healing promoting Performance of liquid dressing of the present invention
1. Test materials
1.1 healthy and early-adult albino rabbits 30 animals are used, male and female are not limited, and the weight is not less than 2 kg.
1.2 test article preparation liquid dressing 3 bottles, 25 ml.
1.3 control
Comparative sample 1, comparative sample 2, and 1 bottle each
1.4 test device
1ml syringe, hair cutter and scalpel
2. Test method
The selected animals are 30 healthy and early-adult albino rabbits, the male and female are not limited, and the weight is not lower than 2 kg. The samples were randomly divided into five groups, comparative sample 1, comparative sample 2, sample 1, sample 2, and sample 3. Feeding at 16-28 deg.C with maximum daily temperature difference of 4 deg.C and relative humidity of 40-70%. Sufficient feed and drinking water (national standard of the people's republic of China) are given every day. The animals were acclimatized for 5 days under the prescribed conditions and tested. Performing intravenous injection anesthesia with 1% sodium pentobarbital, removing hair on the back of the rabbit, removing to expose skin, cutting 7cm long wound surface to below dermis to allow hemorrhage, spraying appropriate amount of test sample on day 1, and covering with gauze; spraying and replacing once a day, when the wound surface does not bleed, directly spraying the test sample without covering gauze, continuously spraying to ensure that the wound surface does not have red swelling and scabbing, comparing the comparison sample 1 and the comparison sample 2 with the sample group, observing and recording the red swelling, scabbing and scabbing conditions of the wound surface
3. The observation results are shown in table 2 below:
TABLE 2
And (4) analyzing results: it can be seen from the table that sample 1, sample 2 and sample 3 all have excellent wound healing ability, and sample 1, sample 2 and sample 3 have substantial progress in wound healing effect compared with comparative sample 1 and comparative sample 2, and demonstrate that the cooperative use of octenidine and fucoidan oligosaccharide has synergistic effect in wound healing.
The octenidine and the brown alginate oligosaccharide have a synergistic effect, and when the octenidine and the brown alginate oligosaccharide are used together, the bacteriostatic ability can be improved, and the wound healing is facilitated; and the formula can form a good physical barrier on the surface of the wound, so that the wound surface can form a moist environment, and the wound healing can be assisted.
The foregoing illustrates and describes the principles, general features, and advantages of the present invention. It should be understood by those skilled in the art that the above embodiments do not limit the present invention in any way, and all technical solutions obtained by using equivalent alternatives or equivalent variations fall within the scope of the present invention.
Claims (8)
1. The liquid dressing is characterized in that the formula comprises the following components in percentage by mass: 0.1-8% of film forming agent, 0.01-0.03% of octenidine, 0.2-10% of humectant, 0.1-5% of substance for promoting wound healing, 0.1-5% of alginate oligosaccharide and 80.89-86.88% of water.
2. The liquid dressing of claim 1, wherein the film-forming agent comprises: polyvinyl alcohol, sodium carboxymethyl cellulose.
3. The liquid dressing of claim 1, wherein the moisturizer comprises: sodium hyaluronate, glycerol.
4. The liquid dressing of claim 1, wherein the wound-healing-promoting substance comprises: centella asiatica extract, allantoin, epidermal growth factor.
5. The preparation method of the liquid dressing is characterized by comprising the following steps:
the materials are prepared in accordance with the formulation,
the formula comprises the following components in percentage by mass: 0.1-8% of film forming agent, 0.01-0.03% of octenidine, 0.2-10% of humectant, 0.1-5% of substance for promoting wound healing, 0.1-5% of alginate oligosaccharide and 80.89-86.88% of water;
slowly adding the film forming agent into water, and then heating to 30-90 ℃ until the film forming agent is completely dissolved;
adding octenidine into the solution, controlling the temperature at 30-50 ℃, and stirring for 20-30 minutes;
adding the humectant into the solution, controlling the temperature to be 20-40 ℃, and stirring for 10-20 minutes;
adding the substance for promoting wound healing into the solution, controlling the temperature to be 20-40 ℃, and stirring for 10-20 minutes;
adding the alginate oligosaccharide into the solution, controlling the temperature at 20-40 ℃, and stirring for 20-30 minutes to obtain the liquid dressing.
6. The method for preparing the liquid dressing according to claim 5, wherein the film forming agent comprises: polyvinyl alcohol, sodium carboxymethyl cellulose.
7. The method for preparing a liquid dressing according to claim 5, wherein the moisturizing agent comprises: sodium hyaluronate, glycerol.
8. The method for preparing a liquid dressing according to claim 5, wherein the wound-healing promoting substance comprises: centella asiatica extract, allantoin, epidermal growth factor.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202011376046.5A CN112370568A (en) | 2020-11-30 | 2020-11-30 | Liquid dressing and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202011376046.5A CN112370568A (en) | 2020-11-30 | 2020-11-30 | Liquid dressing and preparation method thereof |
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| CN112370568A true CN112370568A (en) | 2021-02-19 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN202011376046.5A Pending CN112370568A (en) | 2020-11-30 | 2020-11-30 | Liquid dressing and preparation method thereof |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113289055A (en) * | 2021-05-25 | 2021-08-24 | 振德医疗用品股份有限公司 | Green liquid adhesive bandage with antibacterial function and preparation method thereof |
| CN113607903A (en) * | 2021-07-30 | 2021-11-05 | 振德医疗用品股份有限公司 | Method for detecting bacterial endotoxin containing positive charge polymer |
| CN114028607A (en) * | 2021-11-26 | 2022-02-11 | 青岛鸿蒙草本医疗科技有限公司 | Liquid dressing and preparation method thereof |
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| CN110624127A (en) * | 2019-10-14 | 2019-12-31 | 河南承东生物科技有限公司 | Dual-bacteriostatic healing-promoting liquid dressing and preparation method thereof |
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2020
- 2020-11-30 CN CN202011376046.5A patent/CN112370568A/en active Pending
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113289055A (en) * | 2021-05-25 | 2021-08-24 | 振德医疗用品股份有限公司 | Green liquid adhesive bandage with antibacterial function and preparation method thereof |
| CN113607903A (en) * | 2021-07-30 | 2021-11-05 | 振德医疗用品股份有限公司 | Method for detecting bacterial endotoxin containing positive charge polymer |
| CN113607903B (en) * | 2021-07-30 | 2024-03-15 | 振德医疗用品股份有限公司 | Method for detecting bacterial endotoxin containing positive charge polymer |
| CN114028607A (en) * | 2021-11-26 | 2022-02-11 | 青岛鸿蒙草本医疗科技有限公司 | Liquid dressing and preparation method thereof |
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