CN112354034A - Fish cheek type extracorporeal circulation oxygenator system - Google Patents
Fish cheek type extracorporeal circulation oxygenator system Download PDFInfo
- Publication number
- CN112354034A CN112354034A CN202011333739.6A CN202011333739A CN112354034A CN 112354034 A CN112354034 A CN 112354034A CN 202011333739 A CN202011333739 A CN 202011333739A CN 112354034 A CN112354034 A CN 112354034A
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- Prior art keywords
- oxygenator
- extracorporeal circulation
- oxygenation
- liquid
- pressure
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- 230000004087 circulation Effects 0.000 title claims abstract description 14
- 238000006213 oxygenation reaction Methods 0.000 claims abstract description 22
- 241000251468 Actinopterygii Species 0.000 claims abstract description 6
- 239000012528 membrane Substances 0.000 claims description 21
- 239000007788 liquid Substances 0.000 claims description 20
- 239000012510 hollow fiber Substances 0.000 claims description 19
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 14
- 229910052760 oxygen Inorganic materials 0.000 claims description 14
- 239000001301 oxygen Substances 0.000 claims description 14
- 230000017531 blood circulation Effects 0.000 claims description 8
- 238000000034 method Methods 0.000 claims description 4
- 239000000523 sample Substances 0.000 claims description 4
- 239000008280 blood Substances 0.000 description 17
- 210000004369 blood Anatomy 0.000 description 17
- 238000004519 manufacturing process Methods 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 210000000056 organ Anatomy 0.000 description 3
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 2
- 230000001154 acute effect Effects 0.000 description 2
- 239000003146 anticoagulant agent Substances 0.000 description 2
- 238000007599 discharging Methods 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 239000007789 gas Substances 0.000 description 2
- 210000003462 vein Anatomy 0.000 description 2
- 206010001526 Air embolism Diseases 0.000 description 1
- 208000028399 Critical Illness Diseases 0.000 description 1
- 206010019280 Heart failures Diseases 0.000 description 1
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 description 1
- 208000004756 Respiratory Insufficiency Diseases 0.000 description 1
- 206010049418 Sudden Cardiac Death Diseases 0.000 description 1
- 208000007536 Thrombosis Diseases 0.000 description 1
- 229940127219 anticoagulant drug Drugs 0.000 description 1
- 230000000740 bleeding effect Effects 0.000 description 1
- 230000023555 blood coagulation Effects 0.000 description 1
- 230000036772 blood pressure Effects 0.000 description 1
- 210000004556 brain Anatomy 0.000 description 1
- 230000005587 bubbling Effects 0.000 description 1
- 229910002092 carbon dioxide Inorganic materials 0.000 description 1
- 239000001569 carbon dioxide Substances 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 229960002897 heparin Drugs 0.000 description 1
- 229920000669 heparin Polymers 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 230000004807 localization Effects 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 230000000241 respiratory effect Effects 0.000 description 1
- 201000004193 respiratory failure Diseases 0.000 description 1
- 208000014221 sudden cardiac arrest Diseases 0.000 description 1
- 238000002054 transplantation Methods 0.000 description 1
- 238000013022 venting Methods 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3621—Extra-corporeal blood circuits
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
- A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
- A61M1/1621—Constructional aspects thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
- A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
- A61M1/1698—Blood oxygenators with or without heat-exchangers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/369—Temperature treatment
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- Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Engineering & Computer Science (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Emergency Medicine (AREA)
- Cardiology (AREA)
- External Artificial Organs (AREA)
Abstract
The invention relates to a fish cheek type extracorporeal circulation oxygenator system. The invention provides a fishbone type extracorporeal circulation oxygenator system, which solves various problems in the prior art by using an efficient oxygenation mode and can be used as an efficient conventional auxiliary treatment means and applied in a light state to promote the rapid rehabilitation of a patient. The invention has simple principle, reasonable design, extremely high oxygenation efficiency and safer application.
Description
Technical Field
The invention relates to the field of medical treatment, life science, medical instruments and film material application, in particular to a fish cheek type extracorporeal circulation oxygenator system.
Background
With the continuous development of medical technology and material technology, the function of an extracorporeal membrane lung oxygenator (ECMO) is gradually recognized by people, and the ECMO is widely applied to clinical critical first aid, such as patients with sudden cardiac arrest, patients with acute severe cardiac failure, patients with acute severe respiratory failure and other diseases seriously threatening respiratory cycle function, patients waiting for donor in organ transplantation support and the like to breathe and circulate in vitro so as to maintain the life of the patients, and can win precious time for the rescue of critically ill patients. The oxygenator is the most important component in the ECMO system, and is used for leading blood out of a vein for oxygenation and then injecting the blood back into a body as arterial blood after oxygenation. The early bubbling oxygenator has large damage to blood, is easy to generate air embolism and thrombus and is not safe enough. At present, the clinical application is a hollow fiber membrane oxygenator which is characterized in that blood flows outside a tube, air flows inside the tube and the blood flows outside the hollow fiber. The production process of the special semipermeable membrane hollow fiber is mastered by only a few developed countries, and the special semipermeable membrane hollow fiber still needs to be imported at present, but the oxygenation performance of the semipermeable membrane hollow fiber is still not stable, and blood seepage is often caused in the conventional clinical application process. In order to prevent blood coagulation in the pipeline, a large amount of anticoagulant medicament (such as heparin and the like) is often required to be coated and injected, the pipeline is long, the work of pre-filling and air-discharging is complicated, bubbles enter the blood carelessly slightly, secondary damage can be caused to a patient, the quantity, the speed and the storage temperature of medicament injection are required to be certain conditions, and otherwise internal bleeding of organs and body tissues of the patient can be caused. The operation of the conventional ECMO system can be completed only by a huge team full-force cooperative operation, a large amount of manpower is consumed, the cost is high, and the ECMO system cannot be widely applied.
Disclosure of Invention
In order to solve the technical problems that the traditional extracorporeal circulation oxygenator has a complex structure, long pipelines, complicated work of pre-filling and air-discharging, improper operation, easy secondary damage to a patient, unstable oxygenation performance, frequent occurrence of blood seepage in the using process, high labor consumption, high cost, incapability of being widely applied and the like, the invention provides a fish gill type extracorporeal circulation oxygenator system: the oxygenator consists of a container containing an oxygenation liquid and a semi-permeable membrane hollow fiber bundle (semi-permeable membrane hollow fibers in a bundled parallel state) pipeline soaked in the oxygenation liquid, wherein two ends of the semi-permeable membrane hollow fiber bundle are connected with a blood conveying pipeline in series, and blood flows through the semi-permeable membrane hollow fiber bundle pipeline when the oxygenator is used; high-pressure oxygen in the external air inlet pipeline passes through the refiner and is filled into the oxygenated liquid in a micro-bubble form; the inside of the oxygenator is in a positive pressure state due to the continuous filling of oxygen, a cover with a pressure limiting exhaust valve and a PH value sensor probe is arranged at the container opening, and the pressure value in the container is maintained by the adjustable pressure limiting exhaust valve on the cover. The oxygenation is carried out in liquid, in the same way as the principle of gill of the blood oxygen exchange organ of fish, so that the extracorporeal circulation oxygenator is called as 'membrane gill' rather.
Drawings
FIG. 1 is a schematic diagram of a gill-type extracorporeal circulation oxygenator system of the present invention:
1 is represented by an oxygenator container 2, is represented by a semi-permeable membrane hollow fiber tube 3, is represented by a blood conveying tube
4 is represented by an air inlet pipe 5 and is represented by an oxygen-containing liquid 6 and is represented by a liquid surface
7 for a refiner 8, a container lid 9 for a pressure limiting venting valve
10 denotes a pH sensor probe
Detailed Description
The invention relates to a fishbone-type extracorporeal circulation oxygenator system, wherein an oxygenator of the system consists of a container 1 containing an oxygenation liquid 5 and a semi-permeable membrane hollow fiber bundle 2 (semi-permeable membrane hollow fibers in a bundled parallel state) pipeline soaked in the oxygenation liquid, and two ends of the semi-permeable membrane hollow fiber bundle are connected with a blood conveying pipeline 3 in series. The high-pressure oxygen in the external air inlet pipeline 4 passes through the thinning device 7 and is filled into the oxygenation liquid in a micro-bubble form, so that the oxygenation liquid is rich in dissolved oxygen, and the blood flows through the semi-permeable membrane hollow fiber bundle pipeline to finish oxygenation; the interior of the oxygenator is in a positive pressure state due to the continuous filling of oxygen, and the pressure value in the container is maintained by the adjustable pressure-limiting exhaust valve 9 on the cover 8, so that the pressure of the semi-permeable membrane hollow fiber in the liquid is balanced, no blood seeps out, the liquid is not easy to be polluted, the oxygen in a high-pressure environment is more easily dissolved with the liquid, and the oxygenation efficiency is higher; a pH sensor probe 10 is provided at an appropriate position of the cap (the concentration of carbon dioxide changes the pH value), and the dissolved oxygen of the liquid is monitored to adjust the amount of oxygen supplied and the amount of exhaust gas.
2, the invention relates to a fish cheek type extracorporeal circulation oxygenator system, which comprises: the blood of a patient is led out from a vein and is injected into the oxygenator through a necessary pipeline by a blood pump, the oxygenation mode is that the blood flows through a semi-permeable membrane hollow fiber bundle pipeline soaked in an oxygenation liquid, the blood is injected back into the patient body after gas exchange is completed, the whole oxygenation process is completed, an intelligent program system can be matched to dynamically monitor indexes such as temperature, PH value, blood flow rate, air supply quantity and the like, and meanwhile, the physical signs of the patient such as blood pressure, blood sugar, blood oxygen concentration, electrocardio waves, brain waves and the like are monitored. Because the pipeline is short, anticoagulant drugs can be reduced or not used, and a large amount of medical and human resources are saved; the applied semipermeable membrane material can produce products meeting application requirements by the domestic existing production process level, so that the localization is realized, and the production and use cost is greatly reduced. At that time, the system can be used as an efficient conventional auxiliary treatment means when the condition of the patient is light, and the patient can be promoted to recover more quickly.
Claims (3)
1. A gill formula extracorporeal circulation oxygenator system which characterized in that: the oxygenator consists of a container containing an oxygenation liquid and a semi-permeable membrane hollow fiber bundle pipeline soaked in the oxygenation liquid, and when the oxygenator is used, blood flows through the semi-permeable membrane hollow fiber bundle pipeline; the dissolved oxygen of the oxygen-containing liquid is filled in by high-pressure oxygen provided by an air inlet pipeline in a micro-bubble form through a refiner; the container mouth is provided with a cover with a pressure-limiting exhaust valve and a PH value sensor probe.
2. The gill-type extracorporeal circulation oxygenator system of claim 1, wherein: when the oxygenator is in operation, blood flows through the semi-permeable membrane hollow fiber bundle pipeline soaked in an oxygenation liquid, and the oxygenation process is completed in the liquid.
3. The fish gill type extracorporeal circulation oxygenator system of claim 1 or claim 2, wherein: the oxygenator is designed to be in positive pressure, and the pressure value in the oxygenator is maintained by a pressure limiting exhaust valve on the cover.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202011333739.6A CN112354034A (en) | 2020-11-24 | 2020-11-24 | Fish cheek type extracorporeal circulation oxygenator system |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202011333739.6A CN112354034A (en) | 2020-11-24 | 2020-11-24 | Fish cheek type extracorporeal circulation oxygenator system |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN112354034A true CN112354034A (en) | 2021-02-12 |
Family
ID=74534101
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202011333739.6A Pending CN112354034A (en) | 2020-11-24 | 2020-11-24 | Fish cheek type extracorporeal circulation oxygenator system |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN112354034A (en) |
-
2020
- 2020-11-24 CN CN202011333739.6A patent/CN112354034A/en active Pending
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| PB01 | Publication | ||
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| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20210212 |