CN210186175U

CN210186175U - Needle and system are kept somewhere to sustainable fluid infusion and vein of sampling based on microdialysis

Info

Publication number: CN210186175U
Application number: CN201920104350.0U
Authority: CN
Inventors: Guoyue Shi; 施国跃; Xinguang Zhou; 周信光
Original assignee: East China Normal University
Current assignee: East China Normal University
Priority date: 2019-01-22
Filing date: 2019-01-22
Publication date: 2020-03-27
Anticipated expiration: 2029-01-22

Abstract

The utility model provides a venous indwelling needle based on continuous fluid infusion and sampling in microdialysis, which comprises an indwelling needle sleeve, wherein the indwelling needle sleeve comprises a first cavity, a second cavity and a third cavity; the first cavity is provided with a metal needle head; the second cavity is communicated with the third cavity; the outside of third cavity is equipped with the fluting, fluting department sets up the pellicle. The utility model also provides a continuous sampling and fluid infusion system based on microdialysis, the utility model discloses a noninvasive, real-time, last, carry out vein fluid infusion and sampling in step, have wide application prospect.

Description

Needle and system are kept somewhere to sustainable fluid infusion and vein of sampling based on microdialysis

Technical Field

The utility model relates to the field of medical technology, especially, relate to a clinical vein is stayed needle commonly used, more specifically can be one kind can realize the fluid infusion and sample novel vein that combines and stay needle and system thereof.

Background

The vein indwelling needle, the component part of core is including keeping somewhere the soft pipe in the blood vessel, and the puncture guide needle core of stainless steel, because of its texture is soft, can be crooked along with the vascular shape, be difficult for puncturing the vascular wall and reduced the puncture rate, advantages such as the stay time is long, by wide application in clinical care, can avoid repeated puncture to cause patient's misery on the one hand, protect patient's vein, avoid appearing excessive destruction, on the other hand can supply for clinical treatment, the first aid is used medicine provides convenience, reduce the emergence probability that the acupuncture is hindered, there is certain control action to blood nature disease propagation risk.

The microdialysis technology is a novel membrane sampling technology which is developed from the field of neurochemistry and can sample endogenous substances and in-vivo medicines in real time. In recent years, with the emergence of a large number of modern analysis technologies with high sensitivity and good selectivity, the application of microdialysis in medical research is on the rise, and the real-time, continuous and online detection of medicines and chemical transmitters in body fluid of living animals is realized. The online combined analysis has great advantages compared with the offline measurement. The automatic continuous operation can effectively avoid enzymolysis of the sample due to sampling at room temperature, improve the stability of the sample, save complex sample pretreatment and sample loss and errors caused by the sample pretreatment, and save time and cost.

With the advent of the individual diagnosis and treatment age, how to obtain TDM real-time information (clinical blood concentration monitoring) plays an important role in clinical treatment.

SUMMERY OF THE UTILITY MODEL

An object of the utility model is to solve the problem among the prior art, combine microdialysis sampling technique, constructed a needle is kept somewhere to vein based on microdialysis lasts sampling and fluid infusion, is different from traditional vein and keeps somewhere the needle.

The utility model provides a needle is kept somewhere to sustainable fluid infusion and vein of sampling based on microdialysis, it is including keeping somewhere the needle sleeve pipe. The indwelling needle cannula comprises a first cavity, a second cavity and a third cavity; a metal needle head is arranged in the first cavity; the second cavity is communicated with the third cavity.

The first cavity is a transfusion channel; the tail end of the first cavity is open.

The first cavity is an independent channel, is an infusion part, does not relate to sampling, and is not communicated with sampling parts such as the second cavity and the third cavity.

The second cavity is a perfusion liquid input channel. The third cavity is a dialysate output channel. The second cavity is communicated with the third cavity. The perfusion liquid flows into the third cavity through the second cavity. The second cavity and the third cavity are not communicated with the first cavity.

The outside of third cavity is equipped with the fluting, fluting department sets up the pellicle, and the material exchange can be carried out to the membrane both sides. Preferably, the outer wall of the third cavity is a semi-permeable membrane material. The second and third chambers are sampled by a semi-permeable membrane based on concentration diffusion, preferably with a recovery rate in the range of 10-50%.

The semipermeable membrane is a high-molecular composite material such as regenerated cellulose or polyacrylonitrile material; preferably, the semi-permeable membrane has a molecular cut-off of 20-50 kDa. Preferably, the semipermeable membrane is a PES polyethersulfone material; preferably, the semi-permeable membrane has a molecular cut-off of 30 KDa.

In a specific embodiment, in the venous indwelling needle of the present invention, a flexible catheter for indwelling the indwelling needle in a blood vessel is constructed as a three-cavity pipeline, which includes a perfusion tube, a perfusion inlet tube and a perfusion outlet tube; wherein the perfusion liquid inlet pipe is communicated with the perfusion liquid outlet pipe; and a slot is formed in the outer side of the perfusion liquid outlet pipe, and a semipermeable membrane is covered on the slot. The semipermeable membrane is made of regenerated cellulose or polyacrylonitrile. The molecular cut-off of the semipermeable membrane is between 20 and 50 KDa.

The utility model also provides a continuous sampling and fluid infusion system based on microdialysis, which comprises the venous indwelling needle, a perfusion pump and a sampling instrument; a liquid inlet is formed in the second cavity and communicated with the filling pump; and a liquid outlet is arranged on the third cavity and communicated with the sampling instrument.

The utility model also provides a continuous sampling and fluid infusion method based on microdialysis utilizes aforementioned vein to keep somewhere the needle, the method includes fluid infusion step and sampling step, wherein:

the liquid supplementing step comprises the following steps: the liquid is replenished through the first cavity, namely the transfusion tube;

the sampling step comprises the following steps: perfusate perfused by the perfusion pump flows in through the second cavity, namely the liquid inlet pipe, and is subjected to dynamic extraction on a target object in blood through semipermeable membrane microdialysis to obtain dialysate, and the dialysate flows out through the third cavity, namely the liquid outlet pipe; and continuously monitoring the information molecules in the dialysate in real time through a sampling instrument.

The utility model discloses in, the perfusion fluid includes normal saline, phosphate buffer saline solution or artifical cerebrospinal fluid etc. and is unrestricted, can select etc. according to actual need's target substance difference.

The utility model discloses can carry out real-time, continuous sampling and fluid infusion based on microdialysis simultaneously. Preferably, the flow rate of the perfusion fluid is 2-10. mu.L/min. Preferably, the sampler has a continuous, online, real-time sampling function.

The utility model provides a continuous fluid infusion and sampling vein indwelling needle based on microdialysis, which comprises an indwelling needle sleeve, wherein the indwelling needle sleeve comprises a first cavity, a second cavity and a third cavity, and a metal needle head is arranged in the first cavity; the second cavity is communicated with the third cavity. Wherein the first cavity is a transfusion channel; the second cavity is a perfusion liquid input channel; the third cavity is a dialysate output channel; the outside of third cavity is equipped with the fluting, fluting department sets up the pellicle.

The utility model discloses the vein based on little dialysis that the innovation provided is continuously sampled and fluid infusion is stayed needle, system and method, will stay the needle and keep somewhere the mild pipe in the blood vessel, constitutes three chamber pipelines, wherein is the fluid infusion all the way, and two tunnel are little dialysis sampling pipeline in addition. The utility model provides a vein is kept somewhere the needle and has been established a novel continuous sampling means, provides novel stable sampling scheme for clinical blood concentration monitoring (TDM), establishes the basis for the continuous on-line analysis of blood concentration, has avoided the misery that the blood of getting repeatedly in the TDM led to the fact simultaneously. The utility model discloses based on keep somewhere the needle with traditional and combine together with microdialysis technique, developed a novel vein of multi-functional usage and kept somewhere the needle, collect fluid infusion, sampling as an organic whole, can provide a non-invasive, last, real-time, synchronous scheme for the monitoring of the internal medicine metabolism level of patient. The utility model can be used in the practical application of the monitoring of the therapeutic drugs and the clinical timely intervention.

Drawings

Fig. 1 is the structural schematic diagram of the venous indwelling needle based on micro-dialysis continuous sampling and fluid infusion.

Fig. 2a, 2b, 2c are the sectional views of the venous indwelling needle based on microdialysis continuous sampling and fluid infusion of the present invention.

Fig. 3 is a schematic structural diagram of the continuous sampling and fluid infusion system based on microdialysis.

Fig. 4 is a flow chart of the continuous sampling and fluid infusion method based on microdialysis of the present invention.

Detailed Description

The present invention will be described in further detail with reference to the following specific examples and the accompanying drawings. The procedures, conditions, experimental methods and the like for carrying out the present invention are general knowledge and common general knowledge in the art except for the contents specifically mentioned below, and the present invention is not particularly limited.

In fig. 1-3, 1-first chamber (infusion tube); 2-second cavity (perfusion liquid inlet tube); 21-a liquid inlet; 3-third cavity (perfusate outlet pipe); 31-a liquid outlet; 4-a semi-permeable membrane; 5-a perfusion pump; 6-a sampling instrument; 7-metal needle.

The utility model provides a venous indwelling needle based on micro-dialysis continuous sampling and fluid infusion, which is a soft catheter for indwelling the indwelling needle in a blood vessel, and is constructed into a three-cavity pipeline, comprising a perfusion tube, a perfusion fluid inlet tube and a perfusion fluid outlet tube; the infusion tube is a No. 1 passage which is used as a common vein fluid infusion passage; the second cavity 2 is a perfusion liquid inlet pipe and is used as a perfusion liquid inlet passage; the third cavity 3 is a perfusion liquid outlet pipe and is used as a perfusion liquid outlet passage after dialysis.

As shown in fig. 1-2c, the utility model discloses well pipeline adopts extrusion process to produce a plurality of parallel passageways, wherein second cavity 2 and third cavity 3 UNICOM each other to fluting in the outside of third cavity 3, cover the pellicle on the groove. The semipermeable membrane is made of medical grade semipermeable membranes such as regenerated cellulose or polyacrylonitrile, and the molecular interception amount is 20-50 KDa.

The pipeline of the venous indwelling needle of the utility model can have various forms: as shown in fig. 2a, the second cavity 2 and the third cavity 3 are respectively attached to the tube wall of the first cavity 1; or as shown in fig. 2b, the

passages

1, 2 and 3 of the cavities are coaxially and sequentially nested outwards; or as shown in fig. 2c, the third cavity 3 is attached to the wall of the passageway of the first cavity 1, and the passageway of the third cavity 2 is attached to the wall of the passageway of the third cavity 3. As long as can realize the utility model discloses the structure of sampling principle is all feasible.

As shown in fig. 3, the utility model provides a continuous sampling and fluid infusion system based on microdialysis, including aforementioned vein indwelling needle, perfusion pump and sampling instrument. The venous indwelling needle is based on the microdialysis principle, and aiming at target molecules in a venous blood vessel, the target molecules are diffused into perfusion liquid based on the concentration gradient between the perfusion liquid and blood to obtain dialysate, and the dialysate continuously flows out of the body through the third cavity 3, so that the target molecules are continuously sampled, and a foundation is laid for reflecting the concentration of substances in the blood in real time. Wherein the power of liquid comes from the micro-filling pump in the 3 passageways of second cavity 2 and third cavity, the utility model discloses carry out in vivo, real-time and online sample under the condition that does not disturb the internal normal physiology process, its advantage is that can realize dynamic observation, quantitative analysis, need not to get blood many times, reduces patient's misery.

Preferably, the flow rate of the perfusion fluid is 2-10. mu.L/min. Preferably, the sampler has a continuous, online, real-time sampling function. Preferably, the sample recovery is 10-50%.

As shown in fig. 4, the utility model also provides a continuous sampling and fluid infusion method based on microdialysis, adopts aforementioned continuous sampling and fluid infusion system based on microdialysis, including the following steps: when a patient needs to be replenished with liquid, the liquid can be replenished in a traditional infusion mode, and the liquid can be accurately infused through a micropump. Meanwhile, when the concentration and the metabolic information of the target object in the patient body are required to be measured, physiological saline only needs to be filled through the micropump, flows in through the 2 pipelines of the second cavity body, passes through the semipermeable membrane, is dynamically extracted with the target object in blood based on the microdialysis principle, forms a stable sampling recovery rate, flows out through the 3 pipelines of the third cavity body, is analyzed through a corresponding analytical instrument, and finally realizes the continuous real-time monitoring of the information molecules in the patient body. The utility model discloses continuous sampling and fluid infusion method based on microdialysis, fluid infusion and sampling can be gone on separately simultaneously or separately.

The protection of the present invention is not limited to the above embodiments. Variations and advantages that may occur to those skilled in the art may be incorporated into the invention without departing from the spirit and scope of the inventive concept, and the scope of the appended claims is intended to be protected.

Claims

1. A venous indwelling needle based on continuous fluid infusion and sampling of microdialysis is characterized by comprising an indwelling needle sleeve, wherein the indwelling needle sleeve comprises a first cavity (1), a second cavity (2) and a third cavity (3); a metal needle (7) is arranged in the first cavity (1); the second cavity (2) is communicated with the third cavity (3);

wherein the first cavity (1) is a transfusion channel; the second cavity (2) is a perfusion liquid input channel; the third cavity (3) is a dialysate output channel; the outside of third cavity (3) is equipped with the fluting, fluting department sets up pellicle (4).

2. The microdialysis-based venous indwelling needle for continuous fluid replacement and sampling according to claim 1, wherein said first lumen is open at its distal end.

3. The microdialysis-based venous indwelling needle for sustainable fluid replacement and sampling according to claim 1, where the semipermeable membrane (4) is a polymeric composite; the molecular cutoff of the semipermeable membrane (4) is 20-50 KDa.

4. The microdialysis-based venous indwelling needle for continuous fluid replacement and sampling according to claim 3, wherein said polymeric composite is regenerated cellulose or polyacrylonitrile.

5. A system for continuous fluid infusion and sampling based on microdialysis, characterized in that it comprises a venous indwelling needle according to any one of claims 1 to 4, as well as an infusion pump (5) and a sampler (6); a liquid inlet (21) is formed in the second cavity (2), and the liquid inlet (21) is communicated with the filling pump (5); a liquid outlet (31) is formed in the third cavity (3), and the liquid outlet (31) is communicated with the sampling instrument (6).