CN112351989B - 肽化合物及其治疗用途 - Google Patents

肽化合物及其治疗用途 Download PDF

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Publication number
CN112351989B
CN112351989B CN201980041027.6A CN201980041027A CN112351989B CN 112351989 B CN112351989 B CN 112351989B CN 201980041027 A CN201980041027 A CN 201980041027A CN 112351989 B CN112351989 B CN 112351989B
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peptide
seq
proline
amino acid
peptides
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Chinese (zh)
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CN112351989A (zh
Inventor
艾伦·欧瓦迪亚
艾维·班-席蒙
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Immune Pharmaceuticals Ltd
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Immune Pharmaceuticals Ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Epidemiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Immunology (AREA)
  • Psychiatry (AREA)
  • Ophthalmology & Optometry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
CN201980041027.6A 2018-07-11 2019-07-10 肽化合物及其治疗用途 Active CN112351989B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IL260555 2018-07-11
IL26055518 2018-07-11
PCT/IL2019/050774 WO2020012478A2 (en) 2018-07-11 2019-07-10 Peptide compounds and therapeutic uses of same

Publications (2)

Publication Number Publication Date
CN112351989A CN112351989A (zh) 2021-02-09
CN112351989B true CN112351989B (zh) 2024-03-26

Family

ID=69141375

Family Applications (1)

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CN201980041027.6A Active CN112351989B (zh) 2018-07-11 2019-07-10 肽化合物及其治疗用途

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US (2) US11912790B2 (enExample)
EP (2) EP4566617A3 (enExample)
JP (2) JP7395517B2 (enExample)
KR (1) KR102880543B1 (enExample)
CN (1) CN112351989B (enExample)
AU (2) AU2019300567B2 (enExample)
BR (1) BR112020024748A2 (enExample)
CA (1) CA3100961A1 (enExample)
CO (1) CO2021001290A2 (enExample)
EA (1) EA202190249A1 (enExample)
ES (1) ES3026158T3 (enExample)
HR (1) HRP20250746T1 (enExample)
HU (1) HUE072141T2 (enExample)
IL (2) IL280101B2 (enExample)
MX (1) MX2021000264A (enExample)
PL (1) PL3820882T3 (enExample)
RS (1) RS66946B1 (enExample)
SG (1) SG11202012773QA (enExample)
UA (1) UA130911C2 (enExample)
WO (1) WO2020012478A2 (enExample)
ZA (1) ZA202100587B (enExample)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7395517B2 (ja) 2018-07-11 2023-12-11 イミュニティ ファルマ リミテッド ペプチド化合物およびその治療的用途
IL272074B2 (en) * 2020-01-15 2024-12-01 Immunity Pharma Ltd Peptide compounds and methods of treating diseases using same

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006083906A2 (en) * 2005-02-01 2006-08-10 Attenuon, Llc Compositions containing the anti-angiogenic phscn-peptide
CN101035554A (zh) * 2004-08-23 2007-09-12 维兹曼科学研究所耶达研究与发展有限公司 介导应激反应的肽抑制剂
WO2011033511A1 (en) * 2009-09-17 2011-03-24 Ramot At Tel-Aviv University Ltd. Peptides for the treatment of oxidative stress related disorders
WO2011126882A2 (en) * 2010-03-30 2011-10-13 American Type Culture Collection Therapeutic peptides and their derivatives and therapeutic uses thereof
CN104045703A (zh) * 2013-03-15 2014-09-17 深圳君圣泰生物技术有限公司 一种多肽、多肽衍生物、多肽的可药用盐及药物组合物
CN105209492A (zh) * 2013-03-14 2015-12-30 免疫制药有限公司 抗嗜酸细胞活化趋化因子抗体在治疗炎症性肠病中的应用
CN107001442A (zh) * 2014-07-15 2017-08-01 耶路撒冷希伯来大学伊森姆研究发展公司 Cd44的分离的多肽及其应用

Family Cites Families (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL154600B (nl) 1971-02-10 1977-09-15 Organon Nv Werkwijze voor het aantonen en bepalen van specifiek bindende eiwitten en hun corresponderende bindbare stoffen.
JPS4843906B1 (enExample) * 1970-08-11 1973-12-21
NL154598B (nl) 1970-11-10 1977-09-15 Organon Nv Werkwijze voor het aantonen en bepalen van laagmoleculire verbindingen en van eiwitten die deze verbindingen specifiek kunnen binden, alsmede testverpakking.
NL154599B (nl) 1970-12-28 1977-09-15 Organon Nv Werkwijze voor het aantonen en bepalen van specifiek bindende eiwitten en hun corresponderende bindbare stoffen, alsmede testverpakking.
US3901654A (en) 1971-06-21 1975-08-26 Biological Developments Receptor assays of biologically active compounds employing biologically specific receptors
US3853987A (en) 1971-09-01 1974-12-10 W Dreyer Immunological reagent and radioimmuno assay
US3867517A (en) 1971-12-21 1975-02-18 Abbott Lab Direct radioimmunoassay for antigens and their antibodies
NL171930C (nl) 1972-05-11 1983-06-01 Akzo Nv Werkwijze voor het aantonen en bepalen van haptenen, alsmede testverpakkingen.
US3850578A (en) 1973-03-12 1974-11-26 H Mcconnell Process for assaying for biologically active molecules
US3935074A (en) 1973-12-17 1976-01-27 Syva Company Antibody steric hindrance immunoassay with two antibodies
US3996345A (en) 1974-08-12 1976-12-07 Syva Company Fluorescence quenching with immunological pairs in immunoassays
US4034074A (en) 1974-09-19 1977-07-05 The Board Of Trustees Of Leland Stanford Junior University Universal reagent 2-site immunoradiometric assay using labelled anti (IgG)
US3984533A (en) 1975-11-13 1976-10-05 General Electric Company Electrophoretic method of detecting antigen-antibody reaction
US4098876A (en) 1976-10-26 1978-07-04 Corning Glass Works Reverse sandwich immunoassay
US4879219A (en) 1980-09-19 1989-11-07 General Hospital Corporation Immunoassay utilizing monoclonal high affinity IgM antibodies
US5011771A (en) 1984-04-12 1991-04-30 The General Hospital Corporation Multiepitopic immunometric assay
US4666828A (en) 1984-08-15 1987-05-19 The General Hospital Corporation Test for Huntington's disease
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US4801531A (en) 1985-04-17 1989-01-31 Biotechnology Research Partners, Ltd. Apo AI/CIII genomic polymorphisms predictive of atherosclerosis
US5272057A (en) 1988-10-14 1993-12-21 Georgetown University Method of detecting a predisposition to cancer by the use of restriction fragment length polymorphism of the gene for human poly (ADP-ribose) polymerase
US5192659A (en) 1989-08-25 1993-03-09 Genetype Ag Intron sequence analysis method for detection of adjacent and remote locus alleles as haplotypes
US5281521A (en) 1992-07-20 1994-01-25 The Trustees Of The University Of Pennsylvania Modified avidin-biotin technique
US6432407B1 (en) * 1995-12-12 2002-08-13 Takara Shuzo Co., Ltd. Antigenic protein originating in malassezia
WO1997044447A2 (en) * 1996-05-03 1997-11-27 President And Fellows Of Harvard College Transcriptional activation system, activators, and uses therefor
US6861256B2 (en) * 1997-05-15 2005-03-01 The General Hospital Corporation Therapeutic and diagnostic tools for impaired glucose tolerance conditions
GB9711148D0 (en) * 1997-05-31 1997-07-23 Peptide Therapeutics Ltd Human MAFA
EP0928968A1 (en) 1998-01-12 1999-07-14 Universität Basel Screening method for apoptosis and necrosis
US20090087878A9 (en) * 1999-05-06 2009-04-02 La Rosa Thomas J Nucleic acid molecules associated with plants
CA2443314C (en) 2001-04-03 2006-03-21 The Board Of Trustees Of The Leland Stanford Junior University Method of imaging cell death in vivo
US20040204340A1 (en) * 2003-04-11 2004-10-14 Guilford Pharmaceuticals, Inc. Polyprolyl inhibitors of cyclophilin
US7704953B2 (en) 2006-02-17 2010-04-27 Mdrna, Inc. Phage displayed cell binding peptides
JP2007228925A (ja) * 2006-03-02 2007-09-13 Kaneka Corp 新規酸化酵素及びそれを用いたグリオキサールの製造方法
JP5351495B2 (ja) * 2008-11-05 2013-11-27 国立大学法人東北大学 スーパーオキシドディスムターゼを用いるアセトアルデヒド分解方法
EP2593595B1 (en) * 2010-07-16 2020-03-11 Avantgen, Inc. Novel peptides and uses thereof
WO2012087964A1 (en) * 2010-12-23 2012-06-28 Codexis, Inc. Gene disruptants producing fatty acyl-coa derivatives
EP3263127B1 (en) 2011-05-23 2019-08-21 Yeda Research and Development Co. Ltd Use of akt phosphorylation as a biomarker for prognosing neurodegenerative diseases and treating same
US8802633B1 (en) 2013-03-18 2014-08-12 Board Of Regents, The University Of Texas System Autophagy-inducing peptide analogs
US9453061B2 (en) * 2014-08-06 2016-09-27 Brown University Method and compositions for treatment of calcineurin-related diseases
CA3172682A1 (en) 2015-04-23 2016-10-27 Nantomics, Llc Cancer neoepitopes
WO2017011338A1 (en) 2015-07-10 2017-01-19 President And Fellows Of Harvard College Sortase-mediated coupling of immunogenic polysaccharide-protein conjugates and their use
JP7395517B2 (ja) 2018-07-11 2023-12-11 イミュニティ ファルマ リミテッド ペプチド化合物およびその治療的用途
IL272074B2 (en) 2020-01-15 2024-12-01 Immunity Pharma Ltd Peptide compounds and methods of treating diseases using same

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101035554A (zh) * 2004-08-23 2007-09-12 维兹曼科学研究所耶达研究与发展有限公司 介导应激反应的肽抑制剂
WO2006083906A2 (en) * 2005-02-01 2006-08-10 Attenuon, Llc Compositions containing the anti-angiogenic phscn-peptide
WO2011033511A1 (en) * 2009-09-17 2011-03-24 Ramot At Tel-Aviv University Ltd. Peptides for the treatment of oxidative stress related disorders
WO2011126882A2 (en) * 2010-03-30 2011-10-13 American Type Culture Collection Therapeutic peptides and their derivatives and therapeutic uses thereof
CN105209492A (zh) * 2013-03-14 2015-12-30 免疫制药有限公司 抗嗜酸细胞活化趋化因子抗体在治疗炎症性肠病中的应用
CN104045703A (zh) * 2013-03-15 2014-09-17 深圳君圣泰生物技术有限公司 一种多肽、多肽衍生物、多肽的可药用盐及药物组合物
CN107001442A (zh) * 2014-07-15 2017-08-01 耶路撒冷希伯来大学伊森姆研究发展公司 Cd44的分离的多肽及其应用

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
Electronic interactions of i, i + 1 dithioamides: increased fluorescence quenching and evidence for n-to-p* interactions;Yun Huang等;ChemComm;第52卷(第50期);7798-7801 *
Motoyoshi Nomizu 等.Convulsant peptides related to corticotropin-releasing factor (CRF).1989,第505卷(第50期),326-328. *
unnamed protein product [Tuber aestivum];GenBank: CUS07144.1;NCBI;1-4 *

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AU2024278477B2 (en) 2026-07-09
WO2020012478A2 (en) 2020-01-16
UA130911C2 (uk) 2026-06-17
IL317252A (en) 2025-01-01
SG11202012773QA (en) 2021-01-28
BR112020024748A2 (pt) 2021-03-23
JP2021531246A (ja) 2021-11-18
HRP20250746T1 (hr) 2025-08-15
EP4566617A2 (en) 2025-06-11
KR102880543B1 (ko) 2025-11-04
JP7395517B2 (ja) 2023-12-11
AU2019300567B2 (en) 2024-09-19
EP4566617A3 (en) 2025-10-01
IL280101B2 (en) 2025-05-01
CN112351989A (zh) 2021-02-09
EA202190249A1 (ru) 2021-05-21
WO2020012478A3 (en) 2020-02-20
HUE072141T2 (hu) 2025-10-28
PL3820882T3 (pl) 2025-08-11
US11912790B2 (en) 2024-02-27
US20210261615A1 (en) 2021-08-26
ES3026158T3 (en) 2025-06-10
US20240190919A1 (en) 2024-06-13
AU2024278477A1 (en) 2025-01-30
IL280101A (en) 2021-03-01
MX2021000264A (es) 2021-05-12
CA3100961A1 (en) 2020-01-16
EP3820882A2 (en) 2021-05-19
CO2021001290A2 (es) 2021-02-26
AU2019300567A1 (en) 2021-02-25
ZA202100587B (en) 2022-07-27
RS66946B1 (sr) 2025-07-31
EP3820882B1 (en) 2025-04-02
IL280101B1 (en) 2025-01-01
JP2024026217A (ja) 2024-02-28
JP7682248B2 (ja) 2025-05-23
KR20210045397A (ko) 2021-04-26
EP3820882C0 (en) 2025-04-02

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