CN112351793A - 免疫检查点抑制剂共表达载体 - Google Patents

免疫检查点抑制剂共表达载体 Download PDF

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Publication number
CN112351793A
CN112351793A CN201980044406.0A CN201980044406A CN112351793A CN 112351793 A CN112351793 A CN 112351793A CN 201980044406 A CN201980044406 A CN 201980044406A CN 112351793 A CN112351793 A CN 112351793A
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sequence
antigen
vector
nucleic acid
acid sequence
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Chinese (zh)
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W·布莱尔
K·朱斯
L·吉特林
C·D·斯卡伦
A·R·拉帕波特
G·M·格罗滕布雷格
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Gritstone Bio Inc
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Gritstone Oncology Inc
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Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4414990A3 (en) 2013-01-17 2024-11-06 Personalis, Inc. Methods and systems for genetic analysis
US10125399B2 (en) 2014-10-30 2018-11-13 Personalis, Inc. Methods for using mosaicism in nucleic acids sampled distal to their origin
US11299783B2 (en) 2016-05-27 2022-04-12 Personalis, Inc. Methods and systems for genetic analysis
EP3634449A4 (en) 2017-05-08 2021-03-17 Gritstone Oncology, Inc. ALPHAVIRUS NEOANTIGEN VECTORS
WO2020037302A1 (en) * 2018-08-17 2020-02-20 Gritstone Oncology, Inc. Antigen-binding proteins targeting shared antigens
AU2019374874A1 (en) * 2018-11-07 2021-06-10 Gritstone Bio, Inc. Alphavirus neoantigen vectors and interferon inhibitors
TWI852977B (zh) 2019-01-10 2024-08-21 美商健生生物科技公司 前列腺新抗原及其用途
MX2021014525A (es) 2019-05-30 2022-03-17 Gritstone Bio Inc Adenovirus modificados.
JP7470787B2 (ja) 2019-11-05 2024-04-18 パーソナリス,インコーポレイティド 単一試料からの腫瘍純度の推定
CR20220220A (es) 2019-11-18 2022-09-20 Janssen Biotech Inc Vacunas basadas en calr y jak2 mutantes y sus usos
EP4168569A4 (en) * 2020-06-18 2024-08-07 Personalis, Inc. Machine-learning techniques for predicting surface-presenting peptides
EP4175664A2 (en) 2020-07-06 2023-05-10 Janssen Biotech, Inc. Prostate neoantigens and their uses
CN116438308A (zh) 2020-08-06 2023-07-14 磨石生物公司 多表位疫苗盒
WO2022229966A1 (en) 2021-04-29 2022-11-03 Yeda Research And Development Co. Ltd. T cell receptors directed against ras-derived recurrent neoantigens and methods of identifying same
WO2023034881A1 (en) * 2021-09-02 2023-03-09 Elixirgen Therapeutics, Inc. Temperature-controllable, rna immunotherapeutic for cancer
WO2023059654A1 (en) 2021-10-05 2023-04-13 Personalis, Inc. Customized assays for personalized cancer monitoring

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997041241A1 (en) * 1996-04-25 1997-11-06 GESELLSCHAFT FüR BIOTECHNOLOGISCHE FORSCHUNG MBH (GBF) Polycistronic expression constructs, their use and vaccines
US20140271724A1 (en) * 2013-03-14 2014-09-18 The Wistar Institute Of Anatomy And Biology Methods and compositions for treating or preventing cancer
CN106456724A (zh) * 2013-12-20 2017-02-22 博德研究所 使用新抗原疫苗的联合疗法
WO2017152042A2 (en) * 2016-03-04 2017-09-08 New York University Virus vectors expressing multiple epitopes of tumor associated antigens for inducing antitumor immunity
WO2017192924A1 (en) * 2016-05-04 2017-11-09 Fred Hutchinson Cancer Research Center Cell-based neoantigen vaccines and uses thereof
WO2018161092A1 (en) * 2017-03-03 2018-09-07 New York University Induction and enhancement of antitumor immunity involving virus vectors expressing multiple epitopes of tumor associated antigens and immune checkpoint inhibitors or proteins
CN110545810A (zh) * 2016-11-23 2019-12-06 磨石肿瘤生物技术公司 新抗原的病毒递送

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002061113A2 (en) * 2001-02-01 2002-08-08 The Johns Hopkins University Nucleic acid derived vaccine that encodes an antigen linked to a polypeptide that promotes antigen presentation
EP1434859A2 (en) * 2001-07-25 2004-07-07 New York University Use of glycosylceramides as adjuvants for vaccines against infections and cancer
CA2500955A1 (en) * 2002-10-03 2004-04-15 Genencor International, Inc. Optimized multi-epitope constructs and uses thereof
CA2960096A1 (en) * 2014-09-03 2016-03-10 Bavarian Nordic A/S Methods and compositions for enhancing immune responses
MX2018004544A (es) * 2015-10-12 2018-11-09 Nantomics Llc Composiciones y métodos para los neoepítopos de cáncer viral.
CA3014466A1 (en) * 2016-03-03 2017-09-08 Cue Biopharma, Inc. T-cell modulatory multimeric polypeptides and methods of use thereof

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997041241A1 (en) * 1996-04-25 1997-11-06 GESELLSCHAFT FüR BIOTECHNOLOGISCHE FORSCHUNG MBH (GBF) Polycistronic expression constructs, their use and vaccines
US20140271724A1 (en) * 2013-03-14 2014-09-18 The Wistar Institute Of Anatomy And Biology Methods and compositions for treating or preventing cancer
CN106456724A (zh) * 2013-12-20 2017-02-22 博德研究所 使用新抗原疫苗的联合疗法
WO2017152042A2 (en) * 2016-03-04 2017-09-08 New York University Virus vectors expressing multiple epitopes of tumor associated antigens for inducing antitumor immunity
WO2017192924A1 (en) * 2016-05-04 2017-11-09 Fred Hutchinson Cancer Research Center Cell-based neoantigen vaccines and uses thereof
CN110545810A (zh) * 2016-11-23 2019-12-06 磨石肿瘤生物技术公司 新抗原的病毒递送
WO2018161092A1 (en) * 2017-03-03 2018-09-07 New York University Induction and enhancement of antitumor immunity involving virus vectors expressing multiple epitopes of tumor associated antigens and immune checkpoint inhibitors or proteins

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
N TATSIS等: "Chimpanzee-origin adenovirus vectors as vaccine carriers", GENETHERAPY, vol. 13, pages 421 - 429 *

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