CN112351787A - 人抗aav2衣壳多克隆抗体表位 - Google Patents

人抗aav2衣壳多克隆抗体表位 Download PDF

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Publication number
CN112351787A
CN112351787A CN201980041584.8A CN201980041584A CN112351787A CN 112351787 A CN112351787 A CN 112351787A CN 201980041584 A CN201980041584 A CN 201980041584A CN 112351787 A CN112351787 A CN 112351787A
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aav
gly
pro
asn
thr
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琪·阿达
萧兰·张
中井弘之
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Oregon Health and Science University
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
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    • C12N15/86—Viral vectors
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    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1065—Preparation or screening of tagged libraries, e.g. tagged microorganisms by STM-mutagenesis, tagged polynucleotides, gene tags
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
    • A61K2039/575—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 humoral response
    • C—CHEMISTRY; METALLURGY
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    • C12N2750/00011—Details
    • C12N2750/14011—Parvoviridae
    • C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
    • C12N2750/14122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
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    • C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
    • C12N2750/00011—Details
    • C12N2750/14011—Parvoviridae
    • C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
    • C12N2750/14141—Use of virus, viral particle or viral elements as a vector

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  • Gastroenterology & Hepatology (AREA)
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  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
CN201980041584.8A 2018-05-04 2019-05-06 人抗aav2衣壳多克隆抗体表位 Pending CN112351787A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862667360P 2018-05-04 2018-05-04
US62/667,360 2018-05-04
PCT/US2019/030955 WO2019213668A1 (en) 2018-05-04 2019-05-06 Human anti-aav2 capsid polyclonal antibody epitopes

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CN112351787A true CN112351787A (zh) 2021-02-09

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US (1) US20210292370A1 (https=)
EP (1) EP3799568A4 (https=)
JP (2) JP2021523702A (https=)
CN (1) CN112351787A (https=)
WO (1) WO2019213668A1 (https=)

Cited By (2)

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CN113583112A (zh) * 2021-07-30 2021-11-02 信念医药科技(苏州)有限公司 Aav特异性抗体及其应用
CN114685651A (zh) * 2022-04-15 2022-07-01 三峡大学 一种特异识别aav9衣壳蛋白的多克隆抗体及制备方法

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EP3861010A1 (en) 2018-10-02 2021-08-11 Voyager Therapeutics, Inc. Redirection of tropism of aav capsids
IL293658A (en) * 2019-12-10 2022-08-01 Homology Medicines Inc Adeno-associated virus preparations and a method of using them
US12209251B2 (en) 2020-05-05 2025-01-28 The University Of North Carolina At Chapel Hill Modified adeno-associated virus 5 capsids and uses thereof
CN116096734A (zh) 2020-05-13 2023-05-09 沃雅戈治疗公司 Aav衣壳的向性的重定向
CN113999861B (zh) * 2021-09-08 2024-03-15 三峡大学 腺相关病毒衣壳蛋白保守区多克隆抗体的制备方法及应用
MX2024004936A (es) 2021-11-02 2024-05-08 Voyager Therapeutics Inc Variantes de capsides de aav y sus usos.
WO2025100417A1 (ja) * 2023-11-06 2025-05-15 株式会社ダイセル Ａａｖのフルカプシドに対するアフィニティポリペプチド

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US20130295614A1 (en) * 2012-05-02 2013-11-07 Sangeetha Hareendran Nucleotide sequences, methods, kit and a recombinant cell thereof
US20130310443A1 (en) * 2012-05-15 2013-11-21 University Of Florida Research Foundation, Inc. Aav vectors with high transduction efficiency and uses thereof for gene therapy
CN105247044A (zh) * 2013-05-31 2016-01-13 加利福尼亚大学董事会 腺相关病毒变体及其使用方法
US20170067908A1 (en) * 2014-04-25 2017-03-09 Oregon Health & Science University Methods of viral neutralizing antibody epitope mapping
WO2017058892A2 (en) * 2015-09-28 2017-04-06 The University Of North Carolina At Chapel Hill Methods and compositions for antibody-evading virus vectors

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DK2675902T3 (da) * 2011-02-17 2019-06-03 Univ Pennsylvania Sammensætninger og fremgangsmåder til at ændre vævsspecificitet og forbedre aav9-medieret genoverførsel
FI3445773T3 (fi) * 2016-05-13 2023-03-30 4D Molecular Therapeutics Inc Adenoassosioituneen viruksen kapsidimuunnoksia ja niiden käyttömenetelmiä
BR112020007405A2 (pt) * 2017-10-18 2020-12-08 Regenxbio Inc. Produtos terapêuticos de anticorpo pós-translacionalmente modificados totalmente humanos

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US20130295614A1 (en) * 2012-05-02 2013-11-07 Sangeetha Hareendran Nucleotide sequences, methods, kit and a recombinant cell thereof
US20130310443A1 (en) * 2012-05-15 2013-11-21 University Of Florida Research Foundation, Inc. Aav vectors with high transduction efficiency and uses thereof for gene therapy
CN105247044A (zh) * 2013-05-31 2016-01-13 加利福尼亚大学董事会 腺相关病毒变体及其使用方法
US20170067908A1 (en) * 2014-04-25 2017-03-09 Oregon Health & Science University Methods of viral neutralizing antibody epitope mapping
WO2017058892A2 (en) * 2015-09-28 2017-04-06 The University Of North Carolina At Chapel Hill Methods and compositions for antibody-evading virus vectors

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BRITTNEY L GURDA等: "Mapping a neutralizing epitope onto the capsid of adeno-associated virus serotype 8", 《J VIROL》 *
BRITTNEY L GURDA等: "Mapping a neutralizing epitope onto the capsid of adeno-associated virus serotype 8", 《J VIROL》, vol. 86, no. 15, 31 August 2012 (2012-08-31), pages 7739 - 7751, XP055590574, DOI: 10.1128/JVI.00218-12 *
DAMIEN MARSIC等: "Vector design Tour de Force: integrating combinatorial and rational approaches to derive novel adeno-associated virus variants", 《MOL THER》 *
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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113583112A (zh) * 2021-07-30 2021-11-02 信念医药科技(苏州)有限公司 Aav特异性抗体及其应用
CN114685651A (zh) * 2022-04-15 2022-07-01 三峡大学 一种特异识别aav9衣壳蛋白的多克隆抗体及制备方法
CN114685651B (zh) * 2022-04-15 2023-07-11 三峡大学 一种特异识别aav9衣壳蛋白的多克隆抗体及制备方法

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Publication number Publication date
JP2021523702A (ja) 2021-09-09
EP3799568A4 (en) 2022-07-06
EP3799568A1 (en) 2021-04-07
US20210292370A1 (en) 2021-09-23
JP2024119818A (ja) 2024-09-03
WO2019213668A1 (en) 2019-11-07

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