CN112334193A - Dll3的嵌合受体及其使用方法 - Google Patents

Dll3的嵌合受体及其使用方法 Download PDF

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Publication number
CN112334193A
CN112334193A CN201980025035.1A CN201980025035A CN112334193A CN 112334193 A CN112334193 A CN 112334193A CN 201980025035 A CN201980025035 A CN 201980025035A CN 112334193 A CN112334193 A CN 112334193A
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cell
seq
clone
amino acid
receptor
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Chinese (zh)
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M·J·吉芬
M·托马斯
C·穆劳斯基
R·B·凯斯
L·吴
J·维尔丘斯
R·A·罗德里格斯
J·冯
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American Amgen
Kite Pharma Inc
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American Amgen
Kite Pharma Inc
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    • C07—ORGANIC CHEMISTRY
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    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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    • A61K40/10—Cellular immunotherapy characterised by the cell type used
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CN201980025035.1A 2018-04-10 2019-04-10 Dll3的嵌合受体及其使用方法 Pending CN112334193A (zh)

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US201862655725P 2018-04-10 2018-04-10
US62/655725 2018-04-10
PCT/US2019/026840 WO2019200007A1 (en) 2018-04-10 2019-04-10 Chimeric receptors to dll3 and methods of use thereof

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CN112334193A true CN112334193A (zh) 2021-02-05

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EP (1) EP3773912A1 (https=)
JP (1) JP7479290B2 (https=)
KR (1) KR102951376B1 (https=)
CN (1) CN112334193A (https=)
AR (1) AR114283A1 (https=)
AU (2) AU2019251473A1 (https=)
BR (1) BR112020020857A2 (https=)
CA (1) CA3095920A1 (https=)
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WO2022237647A1 (zh) * 2021-05-08 2022-11-17 上海齐鲁制药研究中心有限公司 针对dll3的结合分子及其应用
WO2024037288A1 (zh) * 2022-08-15 2024-02-22 南京博安生物技术有限公司 一种靶向人dll3抗原的第四代car及其载体的制备和应用
WO2025067338A1 (en) * 2023-09-26 2025-04-03 Nanjing Legend Biotech Co., Ltd. Dll3 binding moieties and uses thereof
WO2025082340A1 (zh) * 2023-10-16 2025-04-24 上海先博生物科技有限公司 一种靶向δ样配体3的CAR及应用
WO2026039940A1 (zh) * 2024-08-19 2026-02-26 南京博安生物技术有限公司 一种增强型靶向dll3蛋白的嵌合抗原受体和突变体以及应用
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CA3160759A1 (en) * 2019-12-05 2021-06-10 Vycellix, Inc. Modulators of the immune escape mechanism for universal cell therapy
WO2021183861A1 (en) 2020-03-12 2021-09-16 Amgen Inc. Method for treatment and prophylaxis of crs in patients comprising a combination of bispecifc antibodies binding to cds x cancer cell and tnfalpha or il-6 inhibitor
US20240317856A1 (en) * 2021-05-10 2024-09-26 Amgen Inc. Dosing regimen for combination therapy targeting dll3 and pd-1
CA3225252A1 (en) 2021-07-14 2023-01-19 Jordan JARJOUR Engineered t cell receptors fused to binding domains from antibodies
AU2023228374A1 (en) 2022-03-03 2024-09-19 Cambridge Enterprise Limited Therapeutic antibodies
CN119546328A (zh) 2022-04-08 2025-02-28 再生元制药公司 多部分受体和信号传导复合物
WO2023199069A1 (en) 2022-04-14 2023-10-19 Crescendo Biologics Limited Chimeric antigen receptor that binds mesothelin
IL317811A (en) 2022-07-25 2025-02-01 Interius Biotherapeutics Inc Mutated polypeptides, compositions containing them and uses thereof
CN116813784B (zh) * 2023-05-17 2024-03-01 星奕昂(上海)生物科技有限公司 靶向dll3的抗体及其应用
GB202402048D0 (en) 2024-02-14 2024-03-27 Bivictrix Ltd Therapeutic antibodies
GB202402046D0 (en) 2024-02-14 2024-03-27 Bivictrix Ltd Therapeutic antibodies
WO2025202653A1 (en) 2024-03-27 2025-10-02 Ucl Business Ltd T-cell therapy targetting mutant calreticulin
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Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12606635B2 (en) 2020-03-12 2026-04-21 Nanjing Legend Biotech Co., Ltd. Glypican-2-binding moieties, chimeric antigen receptors and uses thereof
WO2022206994A1 (en) * 2021-04-02 2022-10-06 Nanjing Legend Biotech Co., Ltd. Engineered immune cells and uses thereof
WO2022237647A1 (zh) * 2021-05-08 2022-11-17 上海齐鲁制药研究中心有限公司 针对dll3的结合分子及其应用
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