CN112316096A - Traditional Chinese medicine volatile oil composition, preparation thereof, preparation method and application of preparation - Google Patents
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Abstract
The invention provides a traditional Chinese medicine volatile oil composition, a preparation thereof, a preparation method of the preparation and an application of the preparation, wherein the composition comprises, by weight, 5-35 parts of ginger volatile oil, 1-25 parts of fistular onion stalk volatile oil, 1-25 parts of perilla leaf volatile oil, 1-25 parts of fermented soybean volatile oil, 1-20 parts of mint volatile oil and 1-5 parts of borneol, the composition is reasonably compatible according to the traditional Chinese medicine 'monarch, minister, assistant and guide', all components have synergistic effects and jointly play the effects of relieving exterior syndrome and dispelling cold, the traditional Chinese medicine volatile oil composition has the advantages of quick drug effect and no side effect, can be directly administrated from a respiratory tract, can directly reach a focus, is simple and convenient, takes effect quickly, can effectively relieve clinical symptoms of chills, sneeze, rhinorrhea, headache and the like in a short period, and is used for preparing a medicine for treating cold.
Description
Technical Field
The invention relates to the field of traditional Chinese medicines, and in particular relates to a traditional Chinese medicine volatile oil composition capable of treating wind-cold type common cold, a traditional Chinese medicine preparation with active ingredients or effective ingredients of the traditional Chinese medicine volatile oil composition, a preparation method of the traditional Chinese medicine preparation, and application of the traditional Chinese medicine volatile oil composition in preparation of a medicine for treating wind-cold type common cold.
Background
The common cold is the most common acute respiratory infectious disease of human beings, and is suffered from the common cold 2 to 6 times per year in average for adults and 6 to 8 times per year in average for children. Cold can cause a significant social and economic burden, and it has been shown by us data that cold causes 23 billion days of miscarriage and 25 billion days of miswork each year, 27 billion visits each year for cold, over-the-counter medication costs nearly $ 20 billion per year to relieve cold symptoms such as cough, and 22.7 billion dollars for antibacterial drugs. In addition, repeated medication, improper combination medication and abuse of antibiotics are frequently used for clinically treating cold, and in addition, the treatment of the cold becomes more and more troublesome due to the continuous variation of viruses in recent years, and the subsequent side effects, complications and drug resistance increase the burden of diseases and even threaten the life of patients.
Early symptoms of the cold mainly comprise nasopharynx catarrhal symptoms, symptoms such as chills, sneezes, nasal obstruction, watery nasal discharge, coughs, fever, headache and the like can be seen, if the early symptoms cannot be effectively treated in time, complications such as bronchitis, rhinitis, pharyngitis, otitis media and the like or primary diseases can be worsened, the health and daily work and life of patients are influenced, and the risk of infecting other people exists, so the early treatment of the cold is very important. The cold is mostly caused by virus infection, however, no specific antiviral drug exists at present, only symptomatic treatment can be realized clinically, and the abuse of antibiotics aggravates the drug resistance of diseases. (Ringjiang waves. experts in normative diagnosis and treatment of common cold J. China department of internal medicine J2012, (4):330 + 333.)
In 2020, the traditional Chinese medicine is deeply involved to play an important role in resisting novel coronavirus pneumonia, and the advantages of the traditional Chinese medicine in treating exogenous diseases are also paid attention to by people. The traditional Chinese medicine considers that the cold is the symptom of disharmony between defensive surface and upper energizer caused by invasion of lung defense by exogenous pathogenic factors, and the cold is mainly wind pathogen. The book Su Wen, Taiyin Yangmen wheel is characterized by: wind pathogen invades from the mouth, nose or skin and fur and often invades the lung and respiratory tract of the upper energizer, so that symptoms of lung dysfunction such as nasal obstruction and watery nasal discharge appear.
Because six qi at four times are different and the quality of human body is different, the cold has different symptoms such as wind cold, wind heat, summer heat and the like in clinic, wherein the early cold is most common due to cold evil, namely the common language of catching cold, and the wind-cold is manifested as severe chillness, light fever, head and body pain, nasal obstruction, watery nasal discharge, pharynx itch and cough, and the symptoms are light and shallow; if the condition is delayed, swollen and sore throat, cough with yellow sputum and yellow and thick nasal discharge may occur, and at this time, cold pathogen is transformed into heat, the condition is aggravated, and the disease is difficult to treat, and is easy to prolong and other diseases are complicated, so the medicines should be applied as early as possible to dispel pathogenic wind-cold and suppress the cold in the light and shallow stage. (Wu Weihua, Wang Xinyue, Chinese medicine science [ M ]. Chinese traditional medicine Press, 7 month 3 rd edition 2012: 69-72.)
The ancient books of traditional Chinese medicine have a plurality of formulas for treating the wind-cold type common cold, but the traditional Chinese medicine has the problems of inconvenient decoction, poor taste, difficult entrance and the like, dosage forms of patent medicines for treating the wind-cold type common cold on the market are granules, oral liquid, capsules, tablets, pills and the like, are difficult to accept by children, need to exert curative effects through gastrointestinal tract absorption and liver and kidney metabolism, have slow onset of action and can also stimulate the gastrointestinal tract, and therefore more convenient, fast and effective medicinal dosage forms need to be explored.
Chinese patent application CN111035751A discloses a wind-cold type common cold conditioning bath powder and a preparation method thereof, wherein the raw material medicines comprise 20-30 parts of purple perilla, 20-30 parts of dried ginger, 5-10 parts of houttuynia cordata, 5-10 parts of wrinkled gianthyssop herb, 5-10 parts of schizonepeta, 3-5 parts of ephedra, 3-5 parts of honeysuckle, 3-5 parts of wild chrysanthemum flower, 1-3 parts of isatis root and 1-3 parts of liquorice. Chinese patent application CN110123892A discloses a herbal cream for treating wind-cold type common cold and a preparation method thereof, wherein the raw material medicines comprise 25-32 parts of angelica dahurica, 7-12 parts of cassia twig, 10-15 parts of notopterygium root, 9-16 parts of divaricate saposhnikovia root, 3-10 parts of white paeony root and 9-13 parts of bitter almond. The two medicines can treat wind-cold type common cold, but the administration modes are medicated bath and external cream, and the drug effect cannot directly reach the disease site through a percutaneous absorption mode.
Chinese patent application CN 110742924A discloses a traditional Chinese medicine volatile oil composition for preventing and inhibiting influenza caused by influenza virus and application thereof, wherein the raw materials comprise 1-35 parts of holy basil volatile oil, 1-15 parts of patchouli volatile oil, 1-15 parts of wild chrysanthemum flower volatile oil and 1-5 parts of borneol. Chinese patent application CN 110522870A discloses a preparation method of a nasal inhalant for removing filth, which comprises rhizoma Atractylodis, folium Artemisiae Argyi, rhizoma Kaempferiae, rhizoma Acori Graminei volatile oil and Borneolum Syntheticum. The two medicaments are administrated through the respiratory tract and can directly reach the focus of a disease, but the ingredients are mainly products for dissipating dampness with aromatics and clearing heat and removing toxicity, mainly aim at influenza caused by warm pathogenic toxins and are not suitable for wind-cold type cold.
Disclosure of Invention
Based on the technical problems in the prior art, the invention aims to provide the traditional Chinese medicine volatile oil composition for treating the wind-cold type common cold, which can be directly administrated through the respiratory tract, so that the medicine components directly act on the affected part, the symptoms of local cough and watery nasal discharge are relieved, and meanwhile, the exterior evil is dispelled to go out by means of relieving the pungent and warm properties of exterior medicines, and the disease condition is cut off.
In order to achieve the purpose, the technical scheme of the invention is as follows:
a traditional Chinese medicine volatile oil composition comprises the following components in parts by weight:
in some embodiments, the traditional Chinese medicine volatile oil composition comprises the following components in parts by weight:
in some embodiments, the traditional Chinese medicine volatile oil composition comprises the following components in parts by weight:
or:
or:
or:
in some embodiments, the ginger volatile oil, the fistular onion stalk volatile oil, the fermented soybean volatile oil, the mint volatile oil and the perilla leaf volatile oil can be prepared by extracting the relevant plants by any one or more methods selected from a water vapor method, a water diffusion steam distillation method, a solvent extraction method and a carbon dioxide supercritical extraction method.
The invention utilizes the characteristic that the volatile oil in the exterior-releasing medicament is extracted and directly administrated through respiratory tract, so that the medicinal components directly act on the affected part to relieve local cough and rhinorrhea symptoms, and simultaneously the pungent and warm properties of the exterior-releasing medicament expel exterior pathogens and block the disease.
The composition provided by the invention takes the ginger volatile oil and the fistular onion stalk volatile oil as monarch drugs, and has the effects of dispelling cold, relieving exterior syndrome and activating yang qi; the perilla leaf volatile oil and the fermented soybean volatile oil are ministerial drugs, so that the effect of relieving exterior syndrome of monarch drugs is enhanced, and meanwhile, the qi is regulated, the restlessness is relieved, the spleen is stimulated, and the discomfort is relieved; the mint volatile oil is an adjuvant drug, combines cold and warm properties, releases exterior syndrome with pungent and cool properties, and prays for the action of dispersing exterior pathogens together; borneol is a guiding drug and has the functions of inducing resuscitation by fragrance and promoting the ascending of drugs. The raw materials are combined to achieve synergistic interaction, so that the effect of treating the initial wind-cold type common cold is achieved. The five medicines are all visible and medicine-food homologous varieties in life, are convenient to obtain materials, do not contain other chemical components, do not bring any negative influence on the environment and the health of human bodies, and are fresh and fragrant in taste and easy to accept in taste.
The invention also aims to provide a traditional Chinese medicine preparation, and the active ingredients or active ingredients of the traditional Chinese medicine preparation are the traditional Chinese medicine volatile oil composition in any embodiment.
In some embodiments, the herbal formulation comprises the herbal volatile oil composition of any of the above embodiments and a pharmaceutically acceptable excipient.
In some embodiments, the pharmaceutically acceptable excipient comprises at least one of a preservative, an emulsifier, a humectant, a thickener.
In some embodiments, the herbal formulation is at least one of an oral nebulizer, a nasal snuff, a nasal drop, and a massage cream.
The invention also aims to provide a preparation method of the traditional Chinese medicine preparation in any one of the above embodiments, which comprises the following steps: mixing and dissolving the ginger volatile oil, the fistular onion stalk volatile oil, the perilla leaf volatile oil, the fermented soybean volatile oil, the mint volatile oil and the borneol, adding pharmaceutically acceptable auxiliary materials, and preparing at least one of an oral atomizing agent, a snuff agent, a nasal drop agent and a massage cream according to a conventional process means.
The invention also aims to provide application of the traditional Chinese medicine volatile oil composition in preparation of a medicine for treating wind-cold type common cold.
Compared with the prior art, the invention has the following beneficial effects:
the traditional Chinese medicine volatile oil composition is prepared by precisely selecting six raw material volatile oils according to a certain weight formula according to years of research and practice experiences of an inventor by combining modern pharmacological research results under the guidance of traditional Chinese medicine theory. The invention only takes the ginger volatile oil, the fistular onion stalk volatile oil, the perilla leaf volatile oil, the fermented soybean volatile oil, the mint volatile oil and the borneol as active ingredients or effective ingredients, the compatibility of the medicines accords with the principle of 'monarch, minister, assistant and guide' of traditional Chinese medicines, the medicines have few medicines, the components have synergistic effect, the efficacies of relieving exterior syndrome and dispelling cold are jointly played, and the invention has the advantages of quick drug effect, no side effect and the like.
Pharmacological experiments carried out by the inventor prove that the invention can obviously reduce the serum inflammatory factor expression of a mouse with the wind-cold type common cold and increase the CD4 in peripheral blood+T、CD8+T content and nasal secretion IgA content, which shows that the invention can effectively induce local and systemic immune reaction and inhibit inflammatory reaction, thereby playing a role in treating wind-cold type common cold.
In addition, the preparation method is simple, has low cost, is a safe and effective traditional Chinese medicine composition, and has good application prospect.
Detailed Description
In the following description, numerous specific details are set forth in order to provide a thorough understanding of the present invention. This invention may, however, be embodied in many different forms and should not be construed as limited to the embodiments set forth herein, but rather should be construed as broadly as the present invention is capable of modification in various respects, all without departing from the spirit and scope of the present invention.
Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. The terminology used in the description of the invention herein is for the purpose of describing particular embodiments only and is not intended to be limiting of the invention.
The ginger volatile oil, the fistular onion stalk volatile oil, the fermented soybean volatile oil, the perilla leaf volatile oil and the mint volatile oil used in the following embodiments are prepared by the following method:
1. preparing ginger volatile oil: cutting 1kg of fresh gingerPerforming microwave vacuum drying treatment, grinding, sieving with 30 mesh sieve, placing into supercritical extraction kettle, extracting at 40 deg.C and 25 L.h under 25MPa-1And dynamically extracting for 100min to obtain the ginger volatile oil.
2. Preparing the fistular onion stalk volatile oil: cutting 1kg fresh Bulbus Allii Fistulosi, microwave vacuum drying, grinding, sieving with 30 mesh sieve, placing into supercritical extraction kettle, extracting at 50 deg.C and 30 L.h under 30MPa-1And dynamically extracting for 120min to obtain fistular onion stalk volatile oil.
3. Preparing fermented soybean volatile oil: cutting 1kg semen Sojae Preparatum, microwave vacuum drying, grinding, sieving with 30 mesh sieve, placing into supercritical extraction kettle, extracting at 50 deg.C and 30MPa, and flow rate of 300 L.h-1And dynamically extracting for 100min to obtain the fermented soybean volatile oil.
4. Preparing perilla leaf volatile oil: pulverizing 1kg of dried folium Perillae, grinding, sieving with 30 mesh sieve, placing into supercritical extraction kettle, extracting at 50 deg.C under 15MPa and 300 L.h-1And dynamically extracting for 30min to obtain folium Perillae volatile oil.
5. Preparing the mint volatile oil: pulverizing 1kg dried herba Menthae, grinding, sieving with 30 mesh sieve, placing into supercritical extraction kettle, extracting at 50 deg.C and 6MPa at flow rate of 300 L.h-1And dynamically extracting for 90min to obtain the mint volatile oil.
The borneol is purchased in a pharmacy or prepared according to the conventional process in the field.
Example 1: preparation of an oral nebulant
Mixing and dissolving 15 parts of ginger volatile oil, 10 parts of fistular onion stalk volatile oil, 10 parts of perilla leaf volatile oil, 10 parts of fermented soybean volatile oil, 6 parts of mint volatile oil and 2 parts of borneol, adding a proper amount of vegetable glycerol as an emulsifier, adding a proper amount of sweet orange essence to adjust the taste, uniformly mixing, and adding an atomizing agent to obtain the traditional Chinese medicine.
Example 2: preparation of snuff
Mixing and dissolving 20 parts of ginger volatile oil, 15 parts of fistular onion stalk volatile oil, 15 parts of perilla leaf volatile oil, 15 parts of fermented soybean volatile oil, 8 parts of mint volatile oil and 3 parts of borneol, adding cotton cores into the mixed solution for soaking for 48 hours, taking out the cotton cores, and filling the cotton cores into an ABS injection molding tube to obtain the injection molding material.
Example 3: preparation of nasal drops
Mixing and dissolving 10 parts of ginger volatile oil, 8 parts of fistular onion stalk volatile oil, 8 parts of perilla leaf volatile oil, 8 parts of fermented soybean volatile oil, 4 parts of mint volatile oil and 1 part of borneol, adding a proper amount of tween 80 serving as an emulsifier, a proper amount of sodium benzoate serving as a preservative, adding a proper amount of deionized water to dilute to 100 times, and mixing and dissolving to obtain the traditional Chinese medicine.
Example 4: preparing massage cream
Mixing and dissolving 20 parts of ginger volatile oil, 15 parts of fistular onion stalk volatile oil, 15 parts of perilla leaf volatile oil, 15 parts of fermented soybean volatile oil, 10 parts of mint volatile oil and 4 parts of borneol, adding a proper amount of vaseline, diluting to 100 times, and mixing. When in use, the composition is applied to acupoints such as Yingxiang, Taiyang, Fengchi, Fengfu, Hegu, etc., and massaged at certain acupoints, and the medicine is absorbed transdermally and stimulates corresponding acupoints to achieve the effects of warming channels, dispelling cold, dispelling pathogenic wind and dredging orifices.
The positive effects of the invention are proved by animal experiments
1. Experimental materials: compositions of the invention (oral nebulant, prepared as in example 1); mouse immunoglobulin g (igg) enzyme linked immunosorbent assay kit; mouse interleukin 6(IL-6) enzyme linked immunosorbent assay kit; mouse tumor necrosis factor alpha (TNF-alpha) enzyme linked immunosorbent assay kit.
2. Experimental animals: 30 SPF-grade BABL/c mice, male, with the mass of 13-15 g. 5, one cage is used for freely eating and drinking water.
3. The experimental method comprises the following steps:
(1) animal grouping and modeling
The BABL/c mice were randomly divided into 3 groups of 10 mice each, control, model, experimental. Wherein, the contrast group is not subjected to molding treatment; the animals of the model group and the experimental group are molded by adopting the following method:
and (3) putting the mouse into a wind-cold stimulation box, controlling the temperature to be 7-13 ℃ and the wind speed to be 25m/s, stopping for 1h after continuously stimulating for 5h, allowing the mouse to freely ingest and drink water, and stopping after continuously stimulating for 5 h. After molding, animals have obvious symptoms of wind-cold type common cold, which is marked by sneezing, moist and loose hair, arch back, increased nasal secretion, reduced food intake and increased drinking water.
(2) Animal administration
The experimental group adopts an ultrasonic atomizer to atomize and administer 0.05mL twice a day, and the model group and the normal group adopt normal saline to atomize and continuously administer 7 d.
(3) Observation index
Recording physiological state of mouse every day, taking blood from eyeball after administration, detecting blood CD4 with flow cytometer+T、CD8+T content, ELISA method for detecting IL-6 and TNF-alpha content in serum, collecting nasal secretion, ELISA method for detecting IgA content, and the test results are shown in tables 1-3.
4. Results of the experiment
(1) General status of mice in each group
Normal mice have bright hair and flexible movement. Listlessness, damp and loose hair, crouched and contracted hunch, sneezing, increased nasal secretion, decreased food intake and increased drinking water after molding. After one week of treatment, the tested group had better spirit, increased activity, obviously decreased sneezing frequency, and increased food intake due to only a small amount of nasal secretion.
TABLE 1 CD4 in peripheral blood of mice in each group+T、CD8+T content (x. + -. s)
Note: in contrast to the blank group,#P<0.05, comparison with model group,. about.P<0.01。
TABLE 2 serum IL-6, TNF-alpha content (x. + -.s) of each group of mice
Note: in contrast to the blank group,##P<0.01, comparison with model group,. about.P<0.01。
TABLE 3 nasal secretion IgA content (x. + -. s) for each group of mice
5. Conclusion of the experiment
According to the experimental results, the compound can obviously relieve the symptoms of sneezing and rhinorrhea of the mice with the wind-cold type common cold, the mental and eating states are improved, the serum inflammatory factors are reduced compared with those in a model group, and the CD4 in the peripheral blood is+T、CD8+The T content and the IgA content of nasal secretion are higher than those of a model group, which indicates that the composition can play a role in treating the wind-cold type common cold by inhibiting inflammatory reaction and inducing local and whole immune reaction.
Typical cases
Typical case 1: when a male is in 4 years old and is not covered at night, the symptoms of nasal obstruction, thin nasal discharge and cough at night are caused by the common cold of wind-cold in 1 day, 6-10 mouths of the aerosol in the example 1 are inhaled every time, and symptoms are eliminated in the morning, the middle and the evening and 4 times before sleep for 2 days.
Typical case 2: when a certain amount of Yang is male, the male is 29 years old, the symptoms of nasal obstruction, watery nasal discharge and sneeze are aggravated after suffering from the wind-cold type common cold, the snuff in the embodiment 2 is used, the snuff is inhaled for 10min every time, 3 times are divided into the morning, the middle and the evening, the nasal cavity is unobstructed when the user inhales the snuff, and the symptoms of the common cold are eliminated after 4 days.
Typical case 3: when the massage cream in the embodiment 4 is used, the massage is carried out on the parts of Yingxiang, Sun, wind pool, Fengfu and Hegu for 10min each time, 3 times in the morning, at noon and at night, the massage feels relaxed immediately, and the symptoms of 3 days are eliminated.
In conclusion, the medicine for treating the wind-cold type common cold prepared by taking the traditional Chinese medicine volatile oil composition provided by the invention as an active ingredient or an active ingredient has the effects of relieving exterior syndrome and dispelling cold, plays a role in treating the wind-cold type common cold by inhibiting inflammatory reaction and inducing local and whole-body immune reaction, has quick drug effect and no side effect, can be directly administrated from a respiratory tract, and enables the medicine to directly reach a focus, or enables the medicine to be absorbed through skin and stimulate corresponding acupuncture points through acupuncture point massage, and is simple, convenient and rapid to take effect.
The technical features of the embodiments described above may be arbitrarily combined, and for the sake of brevity, all possible combinations of the technical features in the embodiments described above are not described, but should be considered as being within the scope of the present specification as long as there is no contradiction between the combinations of the technical features.
The above-mentioned embodiments only express several embodiments of the present invention, and the description thereof is more specific and detailed, but not construed as limiting the scope of the invention. It should be noted that, for a person skilled in the art, several variations and modifications can be made without departing from the inventive concept, which falls within the scope of the present invention. Therefore, the protection scope of the present patent shall be subject to the appended claims.
Claims (10)
1. The traditional Chinese medicine volatile oil composition is characterized by comprising the following components in parts by weight:
2. the traditional Chinese medicine volatile oil composition of claim 1, which comprises the following components in parts by weight:
3. the traditional Chinese medicine volatile oil composition of claim 1, which comprises the following components in parts by weight:
or:
or:
or:
4. the traditional Chinese medicine volatile oil composition as claimed in any one of claims 1 to 3, wherein the ginger volatile oil, the fistular onion stalk volatile oil, the fermented soybean volatile oil, the mint volatile oil and the perilla leaf volatile oil can be prepared by extracting from related plants by any one or more of a steam method, a water diffusion steam distillation method, a solvent extraction method and a carbon dioxide supercritical extraction method.
5. A Chinese medicinal preparation, wherein the effective component or active component is the Chinese medicinal volatile oil composition of any one of claims 1 to 4.
6. The Chinese medicinal preparation according to claim 5, which consists of the Chinese medicinal volatile oil composition of any one of claims 1 to 4 and pharmaceutically acceptable excipients.
7. The Chinese medicinal formulation of claim 6, wherein the pharmaceutically acceptable excipients comprise at least one of preservatives, emulsifiers, humectants, and thickeners.
8. The Chinese medicinal preparation as claimed in claim 6, wherein the Chinese medicinal preparation is at least one of oral nebulant, nasal snuff, nasal drop and massage cream.
9. The method for preparing a Chinese medicinal preparation according to any one of claims 5 to 8, comprising the steps of: mixing and dissolving the ginger volatile oil, the fistular onion stalk volatile oil, the perilla leaf volatile oil, the fermented soybean volatile oil, the mint volatile oil and the borneol, adding pharmaceutically acceptable auxiliary materials, and preparing at least one of an oral atomizing agent, a snuff agent, a nasal drop agent and a massage cream according to a conventional process means.
10. Use of the Chinese medicinal volatile oil composition of any one of claims 1 to 4 in the preparation of a medicament for treating wind-cold type common cold.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202011310733.7A CN112316096A (en) | 2020-11-20 | 2020-11-20 | Traditional Chinese medicine volatile oil composition, preparation thereof, preparation method and application of preparation |
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| CN110841051A (en) * | 2019-12-12 | 2020-02-28 | 河南中医药大学 | External-use ginger and white-cord essential oil for treating migraine |
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| Title |
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| 李勇主编: "《中国中草药图典 上》", 31 January 2019 * |
| 胡其海: "中药外敷脐眼治疗婴幼儿常见病312例", 《湖南中医杂志》 * |
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