CN112273370A - Intelligent isolated organ perfusion regulation and control device and method - Google Patents
Intelligent isolated organ perfusion regulation and control device and method Download PDFInfo
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- CN112273370A CN112273370A CN202011032412.5A CN202011032412A CN112273370A CN 112273370 A CN112273370 A CN 112273370A CN 202011032412 A CN202011032412 A CN 202011032412A CN 112273370 A CN112273370 A CN 112273370A
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/02—Preservation of living parts
- A01N1/0236—Mechanical aspects
- A01N1/0242—Apparatuses, i.e. devices used in the process of preservation of living parts, such as pumps, refrigeration devices or any other devices featuring moving parts and/or temperature controlling components
- A01N1/0247—Apparatuses, i.e. devices used in the process of preservation of living parts, such as pumps, refrigeration devices or any other devices featuring moving parts and/or temperature controlling components for perfusion, i.e. for circulating fluid through organs, blood vessels or other living parts
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Abstract
The invention aims to provide an intelligent isolated organ perfusion regulation device and method, which solve the problem of lack of stable regulation of perfusate dynamic indexes.
Description
Technical Field
The invention relates to the technical field of organ transplantation, in particular to an intelligent isolated organ perfusion regulation and control device and method.
Background
In organ transplantation, organ quality is one of the key factors affecting patient prognosis. During organ transplantation, the blood flow of the donated organ needs to be interrupted, then the organ is taken down and transplanted to a recipient, and then the blood flow is recovered, so that the organ is inevitably subjected to ischemia-reperfusion injury in the process, and the quality of the donated organ is greatly influenced. Therefore, in the field of organ transplantation, a blood-deficiency-free transplantation technique has been started, which perfuses an isolated organ with a perfusate to fully simulate the physiological environment of the organ in the human body. Among them, the stability of perfusion hemodynamics is one of the key modules for simulating normal physiological environment. The blood vessel endothelial cells of the isolated organ can be damaged due to the over-high flow speed and over-high pressure of the perfusate, and thrombus is easily formed after the perfusate is transplanted to a receptor; the perfusion fluid has too low flow rate and too low pressure, which can cause insufficient perfusion of the isolated organ, at the moment, the organ is not completely in an ischemia-free state, and ischemia-reperfusion injury can occur after the organ is transplanted to a receptor.
Patent CN201410384703.9 discloses a cryo-or sub-normothermic preserving device for ex vivo kidney, which has been considered to improve the preservation quality of kidney by perfusing and preserving organs at sub-normothermia, but does not relate to how to intelligently maintain the perfusion kinetics stability. Patent CN201280066672.1 discloses an oxygen supply device for an organ perfusion system, the setup of which has been started to monitor the flow rate of the perfusion fluid, but the adjustment of the kinetics is a manual adjustment.
The above patents all utilize the perfusion mode to improve the preservation quality of isolated organs, but lack the stable regulation of the kinetic index of the perfusate.
Disclosure of Invention
The invention aims to provide an intelligent isolated organ perfusion regulation and control device and method, and solves the problem of lack of stable regulation of perfusate dynamic indexes.
The above object of the present invention is achieved by the following technical solutions:
the utility model provides an intelligent isolated organ fills regulation and control device, its characterized in that, including signal processing and regulation and control system, display screen, peristaltic pump, organ perfusion storehouse, backward flow route, perfusion route, pressure sensor, flow rate sensor, the organ perfusion storehouse in place isolated organ, signal processing and regulation and control system respectively with display screen, peristaltic pump, pressure sensor, flow rate sensor link to each other, pressure sensor, flow rate sensor, peristaltic pump install perfusion route on, perfusion route connect organ perfusion storehouse on, backward flow route connect organ perfusion storehouse on.
Further, the perfusion passage passes through the side wall of the organ perfusion cabin to be connected with the isolated organ.
Further, the backflow passage passes through the bottom of the organ perfusion cabin and is connected with the isolated organ.
Furthermore, perfusate is injected into the organ perfusion cabin, and the perfusate is perfusate based on concentrated red blood cells.
Furthermore, the organ perfusion cabin is internally provided with scales.
An intelligent isolated organ perfusion regulation method comprises the following steps:
s1, setting standard values, and presetting the flow rate range and the pressure range of the perfusion liquid;
s2, the signal processing and regulating system receives the real-time numbers detected by the pressure sensor and the flow rate sensor, and when the flow rate and the pressure values are in the preset range in the step S1, the adjustment is not carried out; when any one of the flow rate and the pressure value exceeds the upper limit of the preset range in the step S1, the signal processing and regulating system outputs a signal to the peristaltic pump, and the rotating speed of the peristaltic pump is reduced until the rotating speed is in the preset range; when any one of the flow rate and the pressure value is lower than the lower limit of the preset range in the step S1, the signal processing and regulating system outputs a signal to the peristaltic pump, and the rotating speed of the peristaltic pump is increased until the rotating speed is in the preset range; when the automatic regulation and control times exceed 5 times and the pressure and the flow rate cannot be regulated to the preset range, the signal processing and regulation and control system transmits signals to the display screen and sends out alarm signals.
In conclusion, the beneficial technical effects of the invention are as follows:
(1) the invention simultaneously regulates and controls two indexes of flow rate and pressure which are very related to the organ preservation effect, so that the flow rate and the pressure are in a limited proper range, and the preservation effect of the isolated organ and the subsequent transplantation success rate are greatly improved;
(2) the regulation and control method is intelligent regulation and control, and the time of the isolated organ in abnormal flow rate and pressure range is reduced through the rapid judgment and regulation and control of the system, so that the workload of nursing staff is greatly reduced.
Drawings
In order to make the objects, technical solutions and advantages of the present invention more apparent, the present invention will be further described in detail with reference to the accompanying drawings, in which:
fig. 1 is a schematic diagram of an intelligent isolated organ blood flow regulation device.
The specific symbols are:
1-a signal processing and regulating system; 2-a display screen; 3-a peristaltic pump; 4-organ perfusion chamber; 5-a return path; 6-perfusion pathway; a P-pressure sensor; f-flow rate sensor.
Detailed Description
In order to more clearly illustrate the embodiments or technical solutions in the prior art of the present invention, the drawings and technical solutions required to be used in the description of the embodiments or the prior art will be briefly described below, it is obvious that the drawings in the following description are only some embodiments of the present invention, and for those skilled in the art, other drawings can be obtained according to the drawings without creative efforts.
The invention is further described below with reference to the accompanying drawings.
Fig. 1 is an intelligent isolated organ blood flow regulating device, comprising: the device comprises a signal processing and regulating device 1, a display screen 2, a peristaltic pump 3, an organ perfusion cabin 4, a backflow passage 5, a perfusion passage 6, a pressure sensor P and a flow rate sensor F.
The signal processing and regulating system 1 is respectively connected with the display screen 2, the peristaltic pump 3, the pressure sensor P and the flow velocity sensor F, the pressure sensor P, the flow velocity sensor F and the peristaltic pump 3 are installed on the perfusion passage 6, the perfusion passage 6 is connected on the organ perfusion cabin 4, and the backflow passage 5 is connected on the organ perfusion cabin 4.
The perfusion passage 6 passes through the side wall of the organ perfusion cabin 4 to be connected with the isolated organ; the reflux passage 5 passes through the bottom of the organ perfusion cabin 4 to be connected with the isolated organ, and scales are arranged inside the organ perfusion cabin 4.
The organ perfusion chamber 4 is filled with perfusion fluid which is based on concentrated red blood cells.
The using method comprises the following steps:
and S1, setting standard values, presetting a flow rate range and a pressure range of the perfusion liquid, wherein the pressure and the flow rate range have different ranges for different organs and are consistent with a physiological range.
S2, the signal processing and regulating system 1 receives the real-time numbers detected by the pressure sensor P and the flow rate sensor F, and when the flow rate and pressure values are in the preset range in the step S1, no adjustment is made; when any one of the flow rate and the pressure value exceeds the upper limit of the preset range in the step S1, the signal processing and regulating system 1 outputs a signal to the peristaltic pump 3, and the rotating speed of the peristaltic pump 3 is reduced until the rotating speed is in the preset range; when any one of the flow rate and the pressure value is lower than the lower limit of the preset range in the step S1, the signal processing and regulating system 1 outputs a signal to the peristaltic pump 3, and the rotating speed of the peristaltic pump 3 is increased until the rotating speed is in the preset range; when the automatic regulation and control times exceed 5 times and still can not regulate the pressure and the flow rate to the preset range, the signal processing and regulation and control system 1 transmits signals to the display screen 2 and sends out alarm signals, manual intervention processing is needed at the moment, and the reason that manual intervention is needed when the automatic regulation and control times cannot be regulated to the normal range may be that: when the ratio of the flow rate to the pressure change is too large, the system is prompted to have too low internal resistance, which is seen in the falling of a pipeline at a certain position of the system or the excessive expansion of a perfused organ blood vessel; when the ratio of the change of the flow rate to the pressure is too small, the increase of the internal resistance of the system is prompted, and the situations of embolism, such as thromboembolism, vascular embolism or thrombosis in an isolated organ, vasoconstriction in the isolated organ and the like occur in the system.
The above description is only an embodiment of the present invention, but the scope of the present invention is not limited thereto, and any changes or substitutions that are not thought of through the inventive work should be included in the scope of the present invention. Therefore, the protection scope of the present invention shall be subject to the protection scope defined by the claims.
Claims (6)
1. The utility model provides an intelligent isolated organ fills regulation and control device, its characterized in that, including signal processing and regulation and control system, display screen, peristaltic pump, organ perfusion storehouse, backward flow route, perfusion route, pressure sensor, flow rate sensor, the organ perfusion storehouse in place isolated organ, signal processing and regulation and control system respectively with display screen, peristaltic pump, pressure sensor, flow rate sensor link to each other, pressure sensor, flow rate sensor, peristaltic pump install perfusion route on, perfusion route connect organ perfusion storehouse on, backward flow route connect organ perfusion storehouse on.
2. The isolated organ perfusion regulation device of claim 1, wherein the perfusion pathway connects to the isolated organ through a sidewall of the organ perfusion compartment.
3. The isolated organ perfusion regulation device of claim 1 or 2, wherein the backflow passage connects to the isolated organ through a bottom of the organ perfusion compartment.
4. The isolated organ perfusion regulation device of claim 1, wherein the organ perfusion compartment is filled with a perfusate, and the perfusate is a concentrated red blood cell-based perfusate.
5. The isolated organ perfusion regulation device of claim 1, wherein the organ perfusion compartment is internally provided with graduations.
6. An intelligent isolated organ perfusion control method based on the intelligent isolated organ perfusion control device of claim 1, comprising the following steps:
s1, setting standard values, and presetting the flow rate range and the pressure range of the perfusion liquid;
s2, the signal processing and regulating system receives the real-time numbers detected by the pressure sensor and the flow rate sensor, and when the flow rate and the pressure values are in the preset range in the step S1, the adjustment is not carried out; when any one of the flow rate and the pressure value exceeds the upper limit of the preset range in the step S1, the signal processing and regulating system outputs a signal to the peristaltic pump, and the rotating speed of the peristaltic pump is reduced until the rotating speed is in the preset range; when any one of the flow rate and the pressure value is lower than the lower limit of the preset range in the step S1, the signal processing and regulating system outputs a signal to the peristaltic pump, and the rotating speed of the peristaltic pump is increased until the rotating speed is in the preset range; when the automatic regulation and control times exceed 5 times and the pressure and the flow rate cannot be regulated to the preset range, the signal processing and regulation and control system transmits signals to the display screen and sends out alarm signals.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113842517A (en) * | 2021-10-11 | 2021-12-28 | 四川大学 | Intelligent regulation and control method for liquid perfusion |
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| CN103719075A (en) * | 2014-01-14 | 2014-04-16 | 吕凌 | Isolated organ preserving device and preserving method thereof |
| CN104186459A (en) * | 2014-08-07 | 2014-12-10 | 中国人民解放军第三〇九医院 | Sub-normal-temperature or low-temperature isolated kidney storage device |
| CN105123672A (en) * | 2015-07-28 | 2015-12-09 | 东南大学 | High-precision constant-temperature perfusion instrument for isolated organs |
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