CN112245551A - Pure traditional Chinese medicine transdermal liniment for treating liver diseases and preparation method thereof - Google Patents

Pure traditional Chinese medicine transdermal liniment for treating liver diseases and preparation method thereof Download PDF

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CN112245551A
CN112245551A CN202011332275.7A CN202011332275A CN112245551A CN 112245551 A CN112245551 A CN 112245551A CN 202011332275 A CN202011332275 A CN 202011332275A CN 112245551 A CN112245551 A CN 112245551A
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liver diseases
treating liver
traditional chinese
radix
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祝松军
李少龙
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    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A61K36/8965—Asparagus, e.g. garden asparagus or asparagus fern
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61K36/185—Magnoliopsida (dicotyledons)
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/35—Caprifoliaceae (Honeysuckle family)
    • A61K36/355—Lonicera (honeysuckle)
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/51—Gentianaceae (Gentian family)
    • A61K36/515—Gentiana
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/65—Paeoniaceae (Peony family), e.g. Chinese peony
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
    • A61K36/708—Rheum (rhubarb)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/74—Rubiaceae (Madder family)
    • A61K36/748—Oldenlandia or Hedyotis
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    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH

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Abstract

The invention provides a pure traditional Chinese medicine transdermal liniment for treating liver diseases and a preparation method thereof, and relates to the technical field of pure traditional Chinese medicines. Relates to a pure traditional Chinese medicine transdermal liniment for treating liver diseases, which is mainly prepared from the following raw materials in parts by weight: 12-15 parts of asparagus cochinchinensis, 12-15 parts of honeysuckle, 12-15 parts of oldenlandia diffusa, 13-18 parts of white paeony root, 12-15 parts of gentian, 15-18 parts of curcuma aromatica, 9-12 parts of glossy ganoderma, 10-15 parts of rheum officinale and 20-25 parts of sweet wormwood herb; also relates to a preparation method of the pure traditional Chinese medicine transdermal liniment for treating liver diseases, which comprises the following steps: s1, putting radix asparagi, flos Lonicerae, herba Hedyotidis Diffusae, radix Paeoniae alba, radix Gentianae, radix Curcumae, Ganoderma lucidum seu japonicum, radix et rhizoma Rhei, and herba Artemisiae Annuae into stone mortar according to the weight parts, and mashing into powder; s2, soaking the mashed mixed powder in 50-100 parts by weight of 75% alcohol for 20-25 days. The embodiment adopts pure Chinese medicinal preparation with small side effect, adopts effective raw materials and reasonable proportion, has reliable curative effect, simple and quick preparation method, and is convenient and safe to use as liniment.

Description

Pure traditional Chinese medicine transdermal liniment for treating liver diseases and preparation method thereof
Technical Field
The invention relates to the technical field of pure traditional Chinese medicines, in particular to a pure traditional Chinese medicine transdermal liniment for treating liver diseases and a preparation method thereof.
Background
Liver disease refers to a lesion that occurs in the liver. Including hepatitis B, hepatitis A, hepatitis C, liver cirrhosis, steatosis, liver cancer, alcoholic liver disease and other liver diseases. Is a common disease with great harmfulness.
Some existing medicines for treating liver diseases are prepared by combining western medicines or a plurality of pure traditional Chinese medicines according to a certain proportion; the preparation method of the existing medicine for treating liver diseases comprises the steps of decoction and/or filtration and/or stewing and the like.
In the process of implementing the embodiment, the inventor finds at least the following problems:
some existing medicines for treating liver diseases adopt western medicines, and side effects are large; in addition, although some pure traditional Chinese medicine compositions are adopted, the selected raw materials and the mixture ratio are not good enough, and the curative effect is not obvious; in addition, some take the form of non-liniments, which are inconvenient and relatively unsafe to use.
The existing preparation method of the medicine for treating the liver diseases has relatively complex process and multiple steps.
Disclosure of Invention
The invention aims to provide a pure traditional Chinese medicine transdermal liniment for treating liver diseases, which solves the technical problems of insignificant curative effect, inconvenient use and unsafe of the existing pure traditional Chinese medicine transdermal liniment for treating liver diseases.
In order to solve the technical problems, the technical scheme of the invention is as follows:
the invention provides a pure traditional Chinese medicine transdermal liniment for treating liver diseases, which is mainly prepared from the following raw materials in parts by weight: 12-15 parts of asparagus, 12-15 parts of honeysuckle, 12-15 parts of oldenlandia diffusa, 13-18 parts of white paeony root, 12-15 parts of gentian, 15-18 parts of curcuma aromatica, 9-12 parts of glossy ganoderma, 10-15 parts of rhubarb and 20-25 parts of sweet wormwood herb.
Further, 13 parts of asparagus, 13 parts of honeysuckle, 14 parts of ophiorrhiza pumila, 15 parts of white paeony root, 13 parts of gentian, 16 parts of radix curcumae, 11 parts of ganoderma lucidum, 13 parts of rheum officinale and 22 parts of sweet wormwood.
The beneficial effect of this scheme does:
the embodiment provides a pure traditional Chinese medicine transdermal liniment for treating liver diseases, which adopts a pure traditional Chinese medicine preparation and has small side effect; the effective raw materials and reasonable proportion are adopted, so that the treatment effect on the hepatopathy is obviously improved; the external liniment is convenient and safe to use when being used as a transdermal liniment.
The invention also aims to provide a preparation method of the pure traditional Chinese medicine transdermal liniment for treating liver diseases, which aims to solve the technical problems of relatively complex preparation process and multiple steps in the existing preparation method of the pure traditional Chinese medicine transdermal liniment for treating liver diseases.
In order to solve the technical problems, the technical scheme of the invention is as follows:
the invention also provides a preparation method of the pure traditional Chinese medicine transdermal liniment for treating liver diseases, which comprises the following steps:
s1, putting radix asparagi, flos Lonicerae, herba Hedyotidis Diffusae, radix Paeoniae alba, radix Gentianae, radix Curcumae, Ganoderma lucidum seu japonicum, radix et rhizoma Rhei, and herba Artemisiae Annuae into stone mortar according to the weight parts, and mashing into powder;
s2, soaking the mashed mixed powder in 50-100 parts by weight of alcohol for 20-25 days.
Further, the mashed mixed powder is put into 75% alcohol with the weight of 50-100 parts to be soaked for 20-25 days.
The beneficial effect of this scheme does:
the embodiment provides a preparation method of a pure traditional Chinese medicine transdermal liniment for treating liver diseases, which comprises the steps of grinding raw materials into powder, and soaking the powder for 20-25 days by using 75% alcohol in a reasonable proportion; grinding into powder is favorable for fully mixing the medicines, and brewing with alcohol for the above days can fully exert the drug effect and synergistic effect of the components. In addition, alcohol has the effect of sterilization and disinfection, and optionally, the concentration of alcohol in the embodiment is 75%, so that the alcohol is more suitable for human skin.
Therefore, the preparation method of the pure traditional Chinese medicine transdermal liniment for treating liver diseases has simple preparation process and few steps, and the pure traditional Chinese medicine composition can be fully dissolved by adopting alcohol, so that the drug effect is fully exerted and the treatment effect is improved.
The effects of the medicines in the invention are as follows:
asparagus: to nourish yin, moisten dryness, clear lung and promote fluid production.
Honeysuckle flower: has the effects of clearing away heat and toxic materials.
White hop: clear heat and remove toxicity, cure abscess and remove dampness.
White peony root: has the effects of warming yang, eliminating dampness, tonifying deficiency, strengthening spleen and stomach, etc.
Gentian: clear heat and dry dampness, purge liver and gallbladder fire.
Turmeric root-tuber: promoting blood circulation to arrest pain, promoting qi circulation to relieve depression, clearing away heart-fire, cooling blood, promoting bile flow, and eliminating jaundice.
Ganoderma lucidum: to replenish qi and blood, calm mind, strengthen spleen and stomach.
Rhubarb: purging heat-toxin, breaking stagnation and removing blood stasis.
Sweet wormwood herb: clear deficiency heat, remove bone-steaming, relieve summer-heat, check malaria, and remove jaundice.
Detailed Description
In order to make the objects, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below, and it is obvious that the described embodiments are a part of the embodiments of the present invention, but not all of the embodiments.
Thus, the following detailed description of the embodiments of the present invention is not intended to limit the scope of the invention as claimed, but is merely representative of selected embodiments of the invention. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Example one
The invention provides a pure traditional Chinese medicine transdermal liniment for treating liver diseases, which is mainly prepared from the following raw materials in parts by weight: 12 parts of asparagus cochinchinensis, 12 parts of honeysuckle, 12 parts of oldenlandia diffusa, 13 parts of white paeony root, 12 parts of gentian, 15 parts of curcuma aromatica, 9 parts of glossy ganoderma, 10 parts of rheum officinale and 20 parts of sweet wormwood herb.
The preparation method of the pure traditional Chinese medicine transdermal liniment for treating liver diseases comprises the following steps:
s1, putting radix asparagi, flos Lonicerae, herba Hedyotidis Diffusae, radix Paeoniae alba, radix Gentianae, radix Curcumae, Ganoderma lucidum seu japonicum, radix et rhizoma Rhei, and herba Artemisiae Annuae into stone mortar according to the weight parts, and mashing into powder;
s2, the mashed mixed powder is put into 75% alcohol with the weight of 50 parts to be soaked for 20 days for use.
Example two
The invention provides a pure traditional Chinese medicine transdermal liniment for treating liver diseases, which is mainly prepared from the following raw materials in parts by weight: 13 parts of asparagus, 13 parts of honeysuckle, 14 parts of oldenlandia diffusa, 15 parts of white peony root, 13 parts of gentian, 16 parts of curcuma aromatica, 11 parts of ganoderma lucidum, 13 parts of rheum officinale and 22 parts of sweet wormwood.
The preparation method of the pure traditional Chinese medicine transdermal liniment for treating liver diseases comprises the following steps:
s1, putting radix asparagi, flos Lonicerae, herba Hedyotidis Diffusae, radix Paeoniae alba, radix Gentianae, radix Curcumae, Ganoderma lucidum seu japonicum, radix et rhizoma Rhei, and herba Artemisiae Annuae into stone mortar according to the weight parts, and mashing into powder;
s2, the mashed mixed powder is put into 75 parts by weight of 75% alcohol to be soaked for 22 days.
EXAMPLE III
The invention provides a pure traditional Chinese medicine transdermal liniment for treating liver diseases, which is mainly prepared from the following raw materials in parts by weight: 15 parts of asparagus cochinchinensis, 15 parts of honeysuckle, 15 parts of oldenlandia diffusa, 18 parts of white paeony root, 15 parts of gentian, 18 parts of curcuma aromatica, 12 parts of glossy ganoderma, 15 parts of rheum officinale and 25 parts of sweet wormwood herb.
The preparation method of the pure traditional Chinese medicine transdermal liniment for treating liver diseases comprises the following steps:
s1, putting radix asparagi, flos Lonicerae, herba Hedyotidis Diffusae, radix Paeoniae alba, radix Gentianae, radix Curcumae, Ganoderma lucidum seu japonicum, radix et rhizoma Rhei, and herba Artemisiae Annuae into stone mortar according to the weight parts, and mashing into powder;
s2, the mashed mixed powder is put into 75% alcohol of 100 parts by weight to be soaked for 25 days.
1 clinical cases
Case selection: 120 patients with liver diseases with confirmed diagnosis are selected, and the course of disease is 2 months to 3 years.
And (3) analyzing the disease condition: the most common liver diseases in clinic are viral hepatitis and liver cirrhosis, the early symptoms of the liver diseases are more and atypical, the symptoms can be manifested as fatigue, weakness, greasiness, anorexia, dyspepsia, nausea, vomiting, abdominal distension, loose stool, right upper abdomen discomfort or distending pain, dull pain and the like, and jaundice also appears in some patients. There may also be liver palms, spider nevi, and breast development in men, testicular atrophy, erectile dysfunction, and prolonged menstruation in women, which are caused by the decreased inactivation of estrogen. In addition, the patients often have face appearance, dark complexion, loss of luster and elasticity due to chronic liver diseases.
2 method of treatment
The using method comprises the following steps: the pure traditional Chinese medicine transdermal liniment prepared by the embodiment of the invention is applied to the whole body except the head; the treatment course comprises three times per day, 30 days as one treatment course, and 3 treatment courses in total, wherein the first treatment course is a remission period, the second treatment course is a recovery period, and the third treatment course is a consolidation period.
Grouping: randomly dividing 120 cases into 3 experimental groups and 3 control groups corresponding to the experimental groups respectively; wherein, each experimental group and the corresponding control group are 20 people.
Experiment group one: the formulation of example one was used;
control group one: on the basis of the formula proportion of the first formula, the amount of each medicine is reduced by 1 part.
Experiment group two: the formulation of example two was used;
control group two: on the basis of the mixture ratio of the second formula, the components of one medicine, namely the asparagus, are reduced.
Experiment group three: the formulation of example three was used;
control group three: on the basis of the mixture ratio of the three formulas in the example, the amount of each medicine is increased by 1 part.
3 judgment of therapeutic effects
According to the standard of the curative effect of the diagnosis of the traditional Chinese medicine symptoms, the following standards are determined:
and (3) curing: the related symptoms are eliminated, and the body related indexes are recovered to be normal.
Improvement: body-related indices and signs improved but were not eradicated.
And (4) invalidation: no obvious change before and after clinical symptoms.
4 therapeutic results
After 3 courses of treatment, the treatment effect of the patients is detailed in the following table:
group name Cure/example Improvement/example Invalid/example High efficiency Cure rate
Experiment set 1 16 2 2 90％ 80％
Control group one 14 3 3 85％ 70％
Experiment group two 18 1 1 95％ 90％
Control group two 14 3 3 85％ 70％
Experiment group III 16 3 1 95％ 80％
Control group III 15 3 2 90％ 75％
Comparative analysis of the data in the table: wherein, compared with the first control group and the third control group, the data of the experimental group is higher than that of the control group, namely, the experimental group has higher effective rate and cure rate, and the cure rate in the two control groups is lower than 80 percent, so the proportion range in the formula is more reasonable; in addition, through comparison of the experimental group II and the control group II, the control group II has certain effect, but the effect of the experimental group II is better, and meanwhile, by combining the data of the other two experimental groups, the formula of 3 experimental groups has higher effective rate and cure rate, namely, the components of the formula are effective in a reasonable proportioning range.
Therefore, the invention adopts effective raw materials and reasonable proportion, obviously improves the treatment effect on liver diseases, has no other serious adverse events in the treatment case during the clinical observation period, and has no obvious difference in some basic indexes of the body before and after treatment.
Finally, it should be noted that: the above embodiments are only used to illustrate the technical solution of the present invention, and not to limit the same; while the invention has been described in detail and with reference to the foregoing embodiments, it will be understood by those skilled in the art that: the technical solutions described in the foregoing embodiments may still be modified, or some or all of the technical features may be equivalently replaced; and the modifications or the substitutions do not make the essence of the corresponding technical solutions depart from the scope of the technical solutions of the embodiments of the present invention.

Claims (4)

1. A pure traditional Chinese medicine transdermal liniment for treating liver diseases is characterized by being mainly prepared from the following raw materials in parts by weight: 12-15 parts of asparagus, 12-15 parts of honeysuckle, 12-15 parts of oldenlandia diffusa, 13-18 parts of white paeony root, 12-15 parts of gentian, 15-18 parts of curcuma aromatica, 9-12 parts of glossy ganoderma, 10-15 parts of rhubarb and 20-25 parts of sweet wormwood herb.
2. The pure traditional Chinese medicine transdermal liniment for treating liver diseases according to claim 1, which is characterized by being mainly prepared from the following raw materials, by weight, 13 parts of asparagus cochinchinensis, 13 parts of honeysuckle, 14 parts of oldenlandia diffusa, 15 parts of white peony root, 13 parts of gentian, 16 parts of curcuma aromatica, 11 parts of ganoderma lucidum, 13 parts of rheum officinale and 22 parts of artemisia apiacea.
3. A method for preparing a pure Chinese medicinal transdermal liniment for treating liver diseases, which is characterized by comprising the preparation method of the pure Chinese medicinal transdermal liniment for treating liver diseases according to claim 1 or 2, and comprises the following steps:
s1, putting radix asparagi, flos Lonicerae, herba Hedyotidis Diffusae, radix Paeoniae alba, radix Gentianae, radix Curcumae, Ganoderma lucidum seu japonicum, radix et rhizoma Rhei, and herba Artemisiae Annuae into stone mortar according to the weight parts, and mashing into powder;
s2, soaking the mashed mixed powder in 50-100 parts by weight of alcohol for 20-25 days.
4. The method for preparing a pure Chinese medicinal transdermal liniment for treating liver diseases according to claim 3, wherein the volume fraction of the alcohol in step S2 is 75%.
CN202011332275.7A 2020-11-24 2020-11-24 Pure traditional Chinese medicine transdermal liniment for treating liver diseases and preparation method thereof Withdrawn CN112245551A (en)

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Application publication date: 20210122