CN112236139A - 用于治疗骨髓增殖性肿瘤和与癌症相关的纤维化的pim激酶抑制剂 - Google Patents

用于治疗骨髓增殖性肿瘤和与癌症相关的纤维化的pim激酶抑制剂 Download PDF

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Publication number
CN112236139A
CN112236139A CN201980037795.4A CN201980037795A CN112236139A CN 112236139 A CN112236139 A CN 112236139A CN 201980037795 A CN201980037795 A CN 201980037795A CN 112236139 A CN112236139 A CN 112236139A
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compound
pharmaceutically acceptable
acceptable salt
cancer
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J·M·福尔克斯
S·L·沃纳
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Sumitomo Pharma Oncology Inc
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Sumitomo Pharma Oncology Inc
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Priority to CN202311331258.5A priority Critical patent/CN117959303A/zh
Priority to CN202311324993.3A priority patent/CN117838695A/zh
Publication of CN112236139A publication Critical patent/CN112236139A/zh
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN201980037795.4A 2018-04-13 2019-04-12 用于治疗骨髓增殖性肿瘤和与癌症相关的纤维化的pim激酶抑制剂 Pending CN112236139A (zh)

Priority Applications (2)

Application Number Priority Date Filing Date Title
CN202311331258.5A CN117959303A (zh) 2018-04-13 2019-04-12 用于治疗骨髓增殖性肿瘤和与癌症相关的纤维化的pim激酶抑制剂
CN202311324993.3A CN117838695A (zh) 2018-04-13 2019-04-12 用于治疗骨髓增殖性肿瘤和与癌症相关的纤维化的pim激酶抑制剂

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
US201862657563P 2018-04-13 2018-04-13
US201862657540P 2018-04-13 2018-04-13
US62/657,540 2018-04-13
US62/657,563 2018-04-13
US201862743469P 2018-10-09 2018-10-09
US62/743,469 2018-10-09
US201862753025P 2018-10-30 2018-10-30
US201862753023P 2018-10-30 2018-10-30
US62/753,025 2018-10-30
US62/753,023 2018-10-30
PCT/US2019/027217 WO2019200254A1 (en) 2018-04-13 2019-04-12 Pim kinase inhibitors for treatment of myeloproliferative neoplasms and fibrosis associated with cancer

Related Child Applications (2)

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CN202311324993.3A Division CN117838695A (zh) 2018-04-13 2019-04-12 用于治疗骨髓增殖性肿瘤和与癌症相关的纤维化的pim激酶抑制剂
CN202311331258.5A Division CN117959303A (zh) 2018-04-13 2019-04-12 用于治疗骨髓增殖性肿瘤和与癌症相关的纤维化的pim激酶抑制剂

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CN112236139A true CN112236139A (zh) 2021-01-15

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CN201980037795.4A Pending CN112236139A (zh) 2018-04-13 2019-04-12 用于治疗骨髓增殖性肿瘤和与癌症相关的纤维化的pim激酶抑制剂
CN202311331258.5A Pending CN117959303A (zh) 2018-04-13 2019-04-12 用于治疗骨髓增殖性肿瘤和与癌症相关的纤维化的pim激酶抑制剂
CN202311324993.3A Pending CN117838695A (zh) 2018-04-13 2019-04-12 用于治疗骨髓增殖性肿瘤和与癌症相关的纤维化的pim激酶抑制剂

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CN202311324993.3A Pending CN117838695A (zh) 2018-04-13 2019-04-12 用于治疗骨髓增殖性肿瘤和与癌症相关的纤维化的pim激酶抑制剂

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US (2) US20210113562A1 (https=)
EP (1) EP3773560A4 (https=)
JP (2) JP2021521170A (https=)
KR (2) KR20260036611A (https=)
CN (3) CN112236139A (https=)
AU (2) AU2019252793A1 (https=)
CA (1) CA3095580A1 (https=)
MX (2) MX2020010556A (https=)
WO (1) WO2019200254A1 (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3812387A1 (en) 2011-07-21 2021-04-28 Sumitomo Dainippon Pharma Oncology, Inc. Heterocyclic protein kinase inhibitors
KR20260008165A (ko) 2019-02-12 2026-01-15 스미토모 파마 아메리카, 인크. 헤테로시클릭 단백질 키나제 억제제를 포함하는 제제
CN120302975A (zh) * 2022-10-31 2025-07-11 住友制药美国公司 治疗骨髓增生性肿瘤的pim1抑制剂

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TW201620519A (zh) * 2014-01-20 2016-06-16 吉李德科學股份有限公司 治療癌症之療法
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