CN112204037A - 用于治疗和预防细菌感染的新氧代喹嗪化合物 - Google Patents

用于治疗和预防细菌感染的新氧代喹嗪化合物 Download PDF

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Publication number
CN112204037A
CN112204037A CN201980036229.1A CN201980036229A CN112204037A CN 112204037 A CN112204037 A CN 112204037A CN 201980036229 A CN201980036229 A CN 201980036229A CN 112204037 A CN112204037 A CN 112204037A
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CN
China
Prior art keywords
methyl
indol
pyrido
oxo
carboxylic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201980036229.1A
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English (en)
Chinese (zh)
Inventor
F·戴伊
丁晓
胡逸民
刘永强
沈宏
师厚光
谭雪菲
周辰刚
周明伟
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of CN112204037A publication Critical patent/CN112204037A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CN201980036229.1A 2018-05-28 2019-05-27 用于治疗和预防细菌感染的新氧代喹嗪化合物 Pending CN112204037A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN2018088728 2018-05-28
CNPCT/CN2018/088728 2018-05-28
PCT/EP2019/063562 WO2019228940A1 (en) 2018-05-28 2019-05-27 Novel oxoquinolizine compounds for the treatment and prophylaxis of bacterial infection

Publications (1)

Publication Number Publication Date
CN112204037A true CN112204037A (zh) 2021-01-08

Family

ID=66912773

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201980036229.1A Pending CN112204037A (zh) 2018-05-28 2019-05-27 用于治疗和预防细菌感染的新氧代喹嗪化合物

Country Status (5)

Country Link
US (1) US20210238197A1 (https=)
EP (1) EP3802549B1 (https=)
JP (1) JP7296992B2 (https=)
CN (1) CN112204037A (https=)
WO (1) WO2019228940A1 (https=)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020064661A1 (en) * 2018-09-26 2020-04-02 F. Hoffmann-La Roche Ag Substituted pyridoindoles for the treatment and prophylaxis of bacterial infection
CN113166174A (zh) * 2018-11-22 2021-07-23 豪夫迈·罗氏有限公司 用于治疗和预防细菌感染的游离氨基化合物
EP3887370B1 (en) * 2018-11-27 2023-01-18 F. Hoffmann-La Roche AG Tricyclic compounds for the treatment and prophylaxis of bacterial infection
WO2020109191A1 (en) * 2018-11-27 2020-06-04 F. Hoffmann-La Roche Ag Aryl compounds for the treatment and prophylaxis of bacterial infection
WO2020127624A1 (en) * 2018-12-20 2020-06-25 F. Hoffmann-La Roche Ag Oxopyrido[1,2-a]pyrimidine compounds for the treatment and prophylaxis of bacterial infection

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003012670A (ja) * 2001-04-10 2003-01-15 Sato Pharmaceutical Co Ltd 抗菌活性を有する４−オキソキノリジン系化合物
CN102015716A (zh) * 2008-02-28 2011-04-13 诺瓦提斯公司 用于治疗C-Met酪氨酸激酶介导的疾病的咪唑并[1,2-b]哒嗪衍生物
US20130245035A1 (en) * 2010-09-27 2013-09-19 Evolva Sa 2-pyridone antimicrobial compositions
CN104837827A (zh) * 2012-12-13 2015-08-12 诺华股份有限公司 吡啶酮衍生物及其在治疗结核病中的用途
WO2018178041A1 (en) * 2017-03-30 2018-10-04 F. Hoffmann-La Roche Ag Novel pyrido[2,3-b]indole compounds for the treatment and prophylaxis of bacterial infection
CN112752762A (zh) * 2018-09-26 2021-05-04 豪夫迈·罗氏有限公司 用于治疗和预防细菌感染的取代的吡啶并吲哚

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2686320B1 (en) 2011-03-15 2016-05-18 Merck Sharp & Dohme Corp. Tricyclic gyrase inhibitors

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003012670A (ja) * 2001-04-10 2003-01-15 Sato Pharmaceutical Co Ltd 抗菌活性を有する４−オキソキノリジン系化合物
CN102015716A (zh) * 2008-02-28 2011-04-13 诺瓦提斯公司 用于治疗C-Met酪氨酸激酶介导的疾病的咪唑并[1,2-b]哒嗪衍生物
US20130245035A1 (en) * 2010-09-27 2013-09-19 Evolva Sa 2-pyridone antimicrobial compositions
CN104837827A (zh) * 2012-12-13 2015-08-12 诺华股份有限公司 吡啶酮衍生物及其在治疗结核病中的用途
WO2018178041A1 (en) * 2017-03-30 2018-10-04 F. Hoffmann-La Roche Ag Novel pyrido[2,3-b]indole compounds for the treatment and prophylaxis of bacterial infection
CN112752762A (zh) * 2018-09-26 2021-05-04 豪夫迈·罗氏有限公司 用于治疗和预防细菌感染的取代的吡啶并吲哚

Also Published As

Publication number Publication date
JP7296992B2 (ja) 2023-06-23
EP3802549B1 (en) 2023-03-01
EP3802549A1 (en) 2021-04-14
US20210238197A1 (en) 2021-08-05
JP2021525745A (ja) 2021-09-27
WO2019228940A1 (en) 2019-12-05

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