CN112190613A - Acupoint desensitization traditional Chinese medicine composition and preparation method thereof - Google Patents
Acupoint desensitization traditional Chinese medicine composition and preparation method thereof Download PDFInfo
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Abstract
The invention relates to an acupoint desensitization traditional Chinese medicine composition and a preparation method thereof, wherein the acupoint desensitization traditional Chinese medicine composition comprises the following raw material components: radix Aconiti lateralis Preparata, semen Sinapis Albae, herba Agastaches, herba asari, flos Caryophylli, radix kansui, cortex Cinnamomi, Olibanum, and rhizoma corydalis. The invention has the beneficial effects that: the traditional Chinese medicine composition for desensitizing acupuncture points disclosed by the invention is prepared by compounding 9 raw materials including prepared monkshood, semen brassicae, agastache rugosus, asarum, clove, euphorbia kansui, cinnamon, frankincense and rhizoma corydalis, so that the raw materials supplement each other and play the roles of warming the lung and dispelling cold, clearing and ventilating lung qi, dredging channels and collaterals and dispelling wind and dredging orifices. Has the characteristics of wide treatment range, short treatment time, high treatment safety and low treatment cost.
Description
Technical Field
The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to an acupoint desensitization traditional Chinese medicine composition and a preparation method thereof.
Background
Currently, in the treatment of allergic diseases, the World Health Organization (WHO) has identified that the most effective is desensitization therapy, mainly by sublingual administration, whereby specific allergens are absorbed sublingually, thus initiating a desensitization reaction. The serum IgG4 level is increased, the cell ratio of Th2/Th1 is improved, for specific desensitization, desensitization treatment is only carried out on specific allergens, and the allergens which are not detected and known are also allergic, and the treatment range is narrow. In addition, the sublingual desensitization time is as long as 2-5 years, and the treatment cost is higher.
Disclosure of Invention
In order to solve the problems in the prior art, the invention provides an acupoint desensitization traditional Chinese medicine composition and a preparation method thereof, the acupoint desensitization traditional Chinese medicine composition is an acupoint non-specific desensitization external medicine, the treatment time is only about 10 days, and the acupoint desensitization traditional Chinese medicine composition has the characteristics of wide treatment range, short treatment time, safety and reliability.
In order to achieve the purpose, the invention adopts the following technical scheme:
an acupoint desensitization traditional Chinese medicine composition comprises the following raw material components: radix Aconiti lateralis Preparata, semen Sinapis Albae, herba Agastaches, herba asari, flos Caryophylli, radix kansui, cortex Cinnamomi, Olibanum, and rhizoma corydalis. Preferably, the acupoint desensitization traditional Chinese medicine composition comprises the following raw material components in parts by weight: 1 to 3 weight portions of prepared aconite, 0.5 to 1.5 weight portions of white mustard seed, 0.5 to 1.5 weight portions of wrinkled gianthyssop herb, 1 to 3 weight portions of asarum, 0.5 to 1.5 weight portions of clove, 0.2 to 1 weight portion of kansui root, 0.2 to 1 weight portion of cinnamon, 0.5 to 1.5 weight portions of frankincense and 0.5 to 1.5 weight portions of rhizoma corydalis. More preferably, the acupoint desensitization traditional Chinese medicine composition comprises the following raw material components in parts by weight: 2 parts of prepared aconite root, 1 part of white mustard seed, 1 part of wrinkled gianthyssop herb, 2 parts of asarum, 1 part of clove, 0.5 part of euphorbia kansui, 0.5 part of cinnamon, 1 part of frankincense and 1 part of rhizoma corydalis.
According to the acupoint desensitization traditional Chinese medicine composition, prepared monkshood is used as a monarch drug for reviving yang and rescuing collapse, tonifying fire and supporting yang and expelling wind-cold-dampness evil. Semen Sinapis Albae has effects of warming lung, eliminating phlegm, activating qi-flowing, resolving hard mass, dredging collaterals and relieving pain; the asarum has the effects of relieving exterior syndrome and dispelling cold, expelling wind and relieving pain, dredging orifices, warming lung and dissolving water, and is used as a ministerial drug together. Gan sui purges water and dispels swelling, subdues swelling and dissipates nodulation; cinnamon has main diseases, nourishes spirit, is color-blended, benefits joints, and tonifies middle-jiao and Qi; the frankincense has the effects of activating blood, promoting qi circulation, relieving pain, eliminating swelling and promoting granulation; rhizoma corydalis is used as adjuvant drug for promoting blood circulation, removing blood stasis, regulating qi-flowing and relieving pain. Agastache rugosus, herba Agastaches, with the effects of eliminating turbid pathogen, regulating the middle warmer and relieving vomiting, relieving exterior syndrome and relieving summer-heat; clove, flos Caryophylli, as a guiding drug, warms the middle-jiao, warms the kidney and lowers adverse qi. The medicines are combined to play the effects of warming lung and dispelling cold, clearing and ventilating lung qi, dredging channels and collaterals, and dispelling wind and dredging orifices.
The acupoint desensitizing traditional Chinese medicine composition is used on acupoints, is stimulated by combining with rational acupoints, has the effect of allergen (allergen), can generate non-specific desensitizing effect, and can increase the level of serum IgG4 and improve the ratio of Th2/Th1 cells. The invention adopts the interdisciplinary thinking of Chinese and western medicine, fully utilizes the acupuncture points and the channels of the traditional Chinese medicine to treat allergic diseases, and combines the acupuncture point and the channels treatment with desensitization. Experiments prove that the acupoint desensitization traditional Chinese medicine composition is effective on various allergic diseases, including but not limited to allergic rhinitis, allergic pharyngitis and allergic asthma. In the treatment of the above diseases, acupoints on both sides of Fengchi, Feishu, Gaohuang and Guanyuan can be selected, and good desensitization can be achieved by combining with thermal or force stimulation, such as local moxibustion and massage.
According to the traditional Chinese medicine composition for desensitization of acupuncture points, the dosage form of the traditional Chinese medicine composition is a pharmaceutical dosage form suitable for external use, and preferably an external paste.
The invention also provides a method for preparing the acupoint desensitization traditional Chinese medicine paste, which comprises the following steps:
(1) respectively drying and pulverizing radix Aconiti lateralis Preparata, semen Sinapis Albae, herba Agastaches, herba asari, flos Caryophylli, radix kansui, cortex Cinnamomi, Olibanum, and rhizoma corydalis to obtain fine powder of each raw material; uniformly mixing the fine powder of each raw material to obtain mixed medicinal powder; preferably, the particle size of each raw material fine powder is 120-300 meshes, and more preferably, the particle size of each raw material fine powder is 200 meshes;
(2) cleaning rhizoma Zingiberis recens, mashing, squeezing with sterile gauze to obtain juice;
(3) adding ginger juice into the mixed medicinal powder, and stirring to obtain a paste, namely the acupoint desensitization traditional Chinese medicine paste, wherein preferably, the volume ratio of the mass of the mixed medicinal powder to the ginger juice is 3g:0.6-1.5 mL.
The invention relates to application of an acupoint desensitization traditional Chinese medicine composition in preparing a medicine for treating allergic diseases.
The invention has the beneficial effects that:
the traditional Chinese medicine composition for desensitizing acupuncture points disclosed by the invention is prepared by compounding 9 raw materials including prepared monkshood, semen brassicae, agastache rugosus, asarum, clove, euphorbia kansui, cinnamon, frankincense and rhizoma corydalis, so that the raw materials supplement each other and play the roles of warming the lung and dispelling cold, clearing and ventilating lung qi, dredging channels and collaterals and dispelling wind and dredging orifices. Has the characteristics of wide treatment range, short treatment time, high treatment safety and low treatment cost.
Detailed Description
In order to make the objects, technical solutions and advantages of the present invention more apparent, the technical solutions of the present invention will be described in detail below. It is to be understood that the described embodiments are merely a few embodiments of the invention, and not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the examples given herein without any inventive step, are within the scope of the present invention. In the following examples, 1 part by weight represents 1 g.
Example 1
The embodiment provides an acupoint desensitization traditional Chinese medicine ointment which is prepared from the following raw material components in parts by weight: 2 parts of prepared aconite root, 1 part of white mustard seed, 1 part of wrinkled gianthyssop herb, 2 parts of asarum, 1 part of clove, 0.5 part of euphorbia kansui, 0.5 part of cinnamon, 1 part of frankincense and 1 part of rhizoma corydalis.
The preparation method of the acupoint desensitization traditional Chinese medicine ointment comprises the following steps:
(1) respectively drying and pulverizing radix Aconiti lateralis Preparata, semen Sinapis Albae, herba Agastaches, herba asari, flos Caryophylli, radix kansui, cortex Cinnamomi, Olibanum, and rhizoma corydalis to obtain fine powder of 200 mesh; uniformly mixing the fine powder of each raw material to obtain mixed medicinal powder;
(2) cleaning rhizoma Zingiberis recens, mashing, squeezing with sterile gauze to obtain juice;
(3) adding ginger juice (3 g of ginger juice: 1mL) into the mixed medicinal powder, and stirring to obtain a paste, namely the acupoint desensitization traditional Chinese medicine paste.
Example 2
The embodiment provides an acupoint desensitization traditional Chinese medicine ointment which is prepared from the following raw material components in parts by weight: 1 part of prepared aconite root, 1.5 parts of white mustard seed, 0.5 part of wrinkled gianthyssop herb, 3 parts of asarum, 0.5 part of clove, 1 part of euphorbia kansui, 0.2 part of cinnamon, 1.5 parts of frankincense and 0.5 part of rhizoma corydalis.
The preparation method of the acupoint desensitization traditional Chinese medicine ointment comprises the following steps:
(1) respectively drying and pulverizing radix Aconiti lateralis Preparata, semen Sinapis Albae, herba Agastaches, herba asari, flos Caryophylli, radix kansui, cortex Cinnamomi, Olibanum, and rhizoma corydalis to obtain fine powder of 120 mesh; uniformly mixing the fine powder of each raw material to obtain mixed medicinal powder;
(2) cleaning rhizoma Zingiberis recens, mashing, squeezing with sterile gauze to obtain juice;
(3) adding ginger juice (3 g of ginger juice: 0.6mL) into the mixed medicinal powder, and stirring to obtain a paste, namely the acupoint desensitization traditional Chinese medicine paste.
Example 3
The embodiment provides an acupoint desensitization traditional Chinese medicine ointment which is prepared from the following raw material components in parts by weight: 3 parts of prepared aconite root, 0.5 part of white mustard seed, 1.5 parts of wrinkled gianthyssop herb, 1 part of asarum, 1.5 parts of clove, 0.2 part of euphorbia kansui, 1 part of cinnamon, 0.5 part of frankincense and 1.5 parts of rhizoma corydalis.
The preparation method of the acupoint desensitization traditional Chinese medicine ointment comprises the following steps:
(1) respectively drying and pulverizing radix Aconiti lateralis Preparata, semen Sinapis Albae, herba Agastaches, herba asari, flos Caryophylli, radix kansui, cortex Cinnamomi, Olibanum, and rhizoma corydalis to obtain fine powder of 300 mesh; uniformly mixing the fine powder of each raw material to obtain mixed medicinal powder;
(2) cleaning rhizoma Zingiberis recens, mashing, squeezing with sterile gauze to obtain juice;
(3) adding ginger juice (3 g of ginger juice: 1.5mL) into the mixed medicinal powder, and stirring to obtain a paste, namely the acupoint desensitization traditional Chinese medicine paste.
Comparative example 1
The comparative example provides an acupoint desensitization traditional Chinese medicine ointment which is the same as the total amount of the raw materials and the preparation method in example 1, and is different only in the mixture ratio of the raw materials. Specifically, the comparative example is prepared from the following raw material components in parts by weight: 0.6 part of prepared aconite root, 1.4 parts of white mustard seed, 2 parts of wrinkled gianthyssop herb, 2 parts of asarum, 1 part of clove, 0.5 part of euphorbia kansui, 0.5 part of cinnamon, 1 part of frankincense and 1 part of rhizoma corydalis.
Comparative example 2
The comparative example provides an acupoint desensitization traditional Chinese medicine ointment, which is different from the embodiment 1 only in that ephedra is used for replacing radix aconiti lateralis preparata, and specifically, the comparative example is prepared from the following raw material components in parts by weight: 2 parts of ephedra, 1 part of white mustard seed, 1 part of wrinkled giant hyssop, 2 parts of asarum, 1 part of clove, 0.5 part of euphorbia kansui, 0.5 part of cinnamon, 1 part of frankincense and 1 part of rhizoma corydalis.
Examples of the experiments
1. Data and method
1.1 general data 120 cases of patients with allergic rhinitis were randomly drawn, and all the cases were outpatient in otorhinolaryngology between 2017 and 2018, and all the patients had symptoms and signs of rhinocnesmus, sneezing, rhinorrhea, nasal obstruction, swelling of nasal mucosa and the like with different degrees. Treatment group 1, treatment group 2, treatment group 3 and control group were randomized. 130 cases in the treatment group, 19 men, 11 women, age 18-55 years; 230 cases in the treatment group, 20 men, 10 women, age 20-46 years; treatment group 330, 20 men, 10 women, age 19-50 years; the control group comprises 30 cases, 18 cases for men and 12 cases for women, and the age is 18-55 years. The difference of sex, age, course of disease, etc. of patients among groups has no significance (P >0.05), and all the treatment drugs are stopped within 7 days before the treatment and 28 days after the treatment.
1.2 diagnostic criteria
1.2.1 reference to the Western medicine diagnosis standard "diagnosis and treatment principles and recommended protocol for allergic rhinitis" 4: (1) paroxysmal rhinocnesmus, nasal obstruction, thin nasal discharge and continuous sneeze are main symptoms accompanied with symptoms of eye conjunctiva itch, lacrimation, pharynx itch and the like; (2) the medicine has the advantages of acute onset, lasting time from minutes to tens of minutes, no nasal discharge and sneezing in intermittent attack, and complicated urticaria and asthma; (3) the disease is often caused by contacting with sensitizing substances such as dust, chemical gas, pollen, cold air or dust mites, and the like, and sometimes the environmental temperature change can be induced; (4) nasal examination for pale mucosa, swollen nasal concha, clear and thin secretion during attack; (5) nasal secretion smears, allergen tests, serum IgE tests help to define the diagnosis. Medical history and specificity tests are the main diagnostic basis.
1.2.2 the standard of diagnosis of traditional Chinese medicine refers to the standard of curative effect of diagnosis of traditional Chinese medicine syndrome of State administration of traditional Chinese medicine 5: (1) the main symptoms are paroxysmal rhinocnesmus, continuous sneezing, nasal obstruction and clear and thin nasal discharge; (2) the onset of the disease is rapid, the symptoms generally last for a plurality of minutes to tens of minutes, and the intermittent period has no sneeze and nasal obstruction; (3) frequently, the disease is caused by contacting with sensitizers such as pollen, smoke dust, chemical gas and the like, and sometimes, the environmental temperature change can be induced; (4) nasal examination is mostly pale with swollen nasal turbinates. There are more clear and thin secretions at onset.
1.3 dialectical basis of dialectical standard allergic rhinitis, according to the Chinese medicine administration 'Standard for the curative Effect of diagnosis of traditional Chinese medicine syndrome' 5: lung deficiency cold: it is usually caused by wind-cold and abnormal qi, manifested as aversion to wind-cold, pale complexion, shortness of breath, cough, white and white sputum. The tongue coating is thin and white and the pulse is superficial.
1.4 methods of treatment group: adopts acupoint application and acupoint moxibustion of a smokeless moxibustion instrument. Selecting Fengchi, Feishu, Gaohuanshu and Guanyuan on two sides, pressing each acupuncture point for a plurality of times by using an acupuncture point pressing bar before moxibustion, then coating desensitization traditional Chinese medicine ointment of the acupuncture points of the embodiment or the comparative example, and then performing moxibustion until a patient feels local warm and comfortable or the skin is flushed, wherein the treatment time is about 30min each time, and the treatment lasts for 7 days, and local skin foaming is taken as the standard. Control group: orally administering desloratadine citrate disodium (1 tablet (8.8mg) 1 time per day for 7 days (Guangzhou Hairy pharmaceutical Co., Ltd., Yangzhou pharmaceutical industry group, national drug Standard H20090138).
1.5 Observation and follow-up of therapeutic effects the therapeutic effects of the symptoms and signs of the two groups of patients before and at the end of treatment and 28 days after the end of treatment were compared according to "diagnosis and treatment principles and recommended protocol for allergic rhinitis" 4. Grading and scoring standard of physical signs: the inferior turbinate is tightly close to the nasal fundus and the nasal septum, the middle turbinate can not be seen, or polyp is formed by polypoid change of the mucosa of the middle turbinate, and the score is 3; the inferior turbinate is tightly close to the nasal septum, and a small gap is arranged between the inferior turbinate and the nasal fundus, and the number is 2; the inferior turbinate is slightly swollen, and the septum and middle turbinate are still visible and scored 1.
1.6 the evaluation standard of the curative effect refers to 'diagnosis and treatment principle and recommendation scheme of allergic rhinitis' 4, the curative effect is evaluated according to the scoring of symptoms and physical signs of patients before and after treatment and after the treatment is finished and the medicine is stopped for 28 days, and the scoring method comprises the following steps: x 100%, score ≧ 66% is significant, 26% -65% is significant, and ≦ 25% is null.
2. Results
The symptoms and sign integral results before treatment, at the end of treatment and 28 days after the end of treatment are compared, namely when the observation of the curative effect is finished, the curative group 1 has 10 effective cases, 18 effective cases and 2 ineffective cases, and the total effective rate is 93.3 percent; the treatment group 2 has 7 cases of obvious effect, 19 cases of effect and 4 cases of no effect, and the total effective rate is 86.7 percent; the treatment group has 3 cases with 6 cases, 19 cases and 5 cases with no effect, and the total effective rate is 83.3 percent; the control group has 10 effective cases, 14 effective cases and 6 ineffective cases, the total effective rate is 80 percent, and the difference between each treatment group and the control group has significant significance (P < 0.05). 28 days after the treatment is finished, the medicine is stopped, the treatment group 1 has 7 cases of obvious effect, 18 cases of effect and 5 cases of no effect, and the total effective rate is 83.3 percent; the treatment group 2 has 6 effective cases, 18 effective cases and 6 ineffective cases, and the total effective rate is 80 percent; the treatment group 3 has 4 cases of obvious effect, 17 cases of effect and 9 cases of no effect, and the total effective rate is 70 percent; the control group has 6 effective cases, 14 effective cases and 10 ineffective cases, the total effective rate is 66.7 percent, and the difference between each treatment group and the control group has significant significance (P < 0.05). The results show that the total effective rate of the treatment group 1 at the end of treatment and 28 days after the end of treatment is stopped is obviously higher than that of the other treatment groups and the control group, and the results show that the acupoint desensitization traditional Chinese medicine ointment has scientific raw material compatibility, reasonable proportion and more prominent effect of treating allergic rhinitis.
The above description is only for the specific embodiments of the present invention, but the scope of the present invention is not limited thereto, and any person skilled in the art can easily conceive of the changes or substitutions within the technical scope of the present invention, and all the changes or substitutions should be covered within the scope of the present invention. Therefore, the protection scope of the present invention shall be subject to the protection scope of the appended claims.
Claims (10)
1. The acupoint desensitization traditional Chinese medicine composition is characterized by comprising the following raw material components: radix Aconiti lateralis Preparata, semen Sinapis Albae, herba Agastaches, herba asari, flos Caryophylli, radix kansui, cortex Cinnamomi, Olibanum, and rhizoma corydalis.
2. The acupoint desensitization traditional Chinese medicine composition according to claim 1, which is characterized by comprising the following raw material components in parts by weight:
1 to 3 weight portions of prepared aconite, 0.5 to 1.5 weight portions of white mustard seed, 0.5 to 1.5 weight portions of wrinkled gianthyssop herb, 1 to 3 weight portions of asarum, 0.5 to 1.5 weight portions of clove, 0.2 to 1 weight portion of kansui root, 0.2 to 1 weight portion of cinnamon, 0.5 to 1.5 weight portions of frankincense and 0.5 to 1.5 weight portions of rhizoma corydalis.
3. The acupoint desensitization traditional Chinese medicine composition according to claim 2, which is characterized by comprising the following raw material components in parts by weight:
2 parts of prepared aconite root, 1 part of white mustard seed, 1 part of wrinkled gianthyssop herb, 2 parts of asarum, 1 part of clove, 0.5 part of euphorbia kansui, 0.5 part of cinnamon, 1 part of frankincense and 1 part of rhizoma corydalis.
4. The acupoint-desensitized traditional Chinese medicine composition according to any one of claims 1 to 3, wherein the dosage form of the traditional Chinese medicine composition is a pharmaceutical dosage form suitable for external use.
5. The acupoint-desensitized traditional Chinese medicine composition according to claim 4, wherein the dosage form of the traditional Chinese medicine composition is external ointment.
6. A method for preparing the acupoint desensitized traditional Chinese medicine ointment of claim 5, which is characterized by comprising the following steps:
(1) respectively drying and pulverizing radix Aconiti lateralis Preparata, semen Sinapis Albae, herba Agastaches, herba asari, flos Caryophylli, radix kansui, cortex Cinnamomi, Olibanum, and rhizoma corydalis to obtain fine powder of each raw material; uniformly mixing the fine powder of each raw material to obtain mixed medicinal powder;
(2) cleaning rhizoma Zingiberis recens, mashing, squeezing with sterile gauze to obtain juice;
(3) adding ginger juice into the mixed medicinal powder, and stirring to obtain a paste, namely the acupoint desensitization traditional Chinese medicine paste.
7. The production method according to claim 6, wherein in the step (1), the particle size of each raw material fine powder is 120 to 300 mesh.
8. The production method according to claim 7, wherein the particle size of each raw material fine powder is 200 mesh.
9. The preparation method according to claim 6, wherein in the step (3), the ratio of the mass of the mixed medicinal powder to the volume of the ginger juice is 3g:0.6-1.5 mL.
10. Use of the acupoint-desensitized traditional Chinese medicine composition according to any one of claims 1 to 5 in the preparation of a medicament for treating allergic diseases.
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Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102302559A (en) * | 2011-09-15 | 2012-01-04 | 上海交通大学医学院附属新华医院 | Medicament for treating respiratory system diseases and application thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102302559A (en) * | 2011-09-15 | 2012-01-04 | 上海交通大学医学院附属新华医院 | Medicament for treating respiratory system diseases and application thereof |
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| 刘岩红: "穴位贴敷治疗过敏性鼻炎1000例", 《中国针灸》 * |
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