CN115381870A - Traditional Chinese medicine composition and medicament for treating rhinitis of children and preparation method thereof - Google Patents
Traditional Chinese medicine composition and medicament for treating rhinitis of children and preparation method thereof Download PDFInfo
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Abstract
The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine composition for treating rhinitis of children, a medicament and a preparation method thereof. The invention relates to a traditional Chinese medicine composition for treating rhinitis of children, which is prepared from the following medicinal materials in parts by weight: the traditional Chinese medicine composition is obtained by directly sticking the medicines on corresponding acupuncture points by only adopting the conventional adhesive plaster to directly stick the medicines, so that the children resistance can be enhanced, the defensive yang strengthening effect can be achieved, and the children rhinitis can be prevented and treated. The preparation method of the medicament for treating the rhinitis of children is simple and easy to produce.
Description
Technical Field
The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine composition and a medicament for treating rhinitis of children and a preparation method thereof
Background
Chronic rhinitis is a chronic inflammation of the nasal mucosa and submucosa. The main characteristics are that the inflammation lasts for more than three months or attacks repeatedly, the intermittence period can not be recovered to normal, and no definite pathogenic microorganism exists, and the nasal obstruction with different degrees, secretion increase, swelling or thickening of nasal mucosa and other obstacles are accompanied. At present, the chronic rhinitis is treated by glucocorticoids such as the glucocorticoids budesonide, mometasone furoate, fluticasone propionate and the like, has the effects of resisting inflammation and allergy, can promote the repair of damaged ciliated epithelium, and relieve the edema and the congestion degree of mucous membranes of respiratory tract and nasal cavity. Vasoconstrictor is also used, but the main components of the vasoconstrictor are benfuresate nasal drops, ephedra alkaline solution of 0.5 to 1 percent, oxymetazoline of 0.05 percent, xylometazoline nasal drops of 0.1 to 0.05 percent and the like, and the vasoconstrictor has the main effect of relieving nasal obstruction symptoms of chronic rhinitis. However, long-term use of such drugs can cause damage to the nasal mucosa.
Aiming at the disadvantages of the prior art, the conventional treatment technology of chronic rhinitis mostly adopts oral administration, nasal drops and smearing paste, and the application of external acupuncture points is rare. Although patches are also most often limited to three volt days of use. With the juvenile onset of chronic rhinitis patients, most of the existing medicines do not have specific chronic rhinitis medicines for children, a few patent technologies for treating chronic rhinitis for children by external application exist, most of the existing medicines are evolved by taking the formula of the Sanfu plaster in Zhang Yi Tong as a base prescription, and the problem of chronic rhinitis for children at present cannot be effectively solved.
Disclosure of Invention
The invention aims to provide a traditional Chinese medicine composition for treating rhinitis of children, which is obtained by the synergistic effect of monarch drug angelica dahurica, ministerial drug asarum and centipeda minima, and adjuvant drug cinnamon and messenger drug borneol.
The second object of the present invention is to provide a medicament for treating rhinitis in children, which can satisfy the medicinal requirements of children patients by obtaining a simple external application paste.
The third purpose of the invention is to provide a preparation method of the medicament for treating the rhinitis of children, which is simple and easy to produce.
The invention is realized by the following technical scheme:
in a first aspect, the invention provides a traditional Chinese medicine composition for treating rhinitis of children, which is prepared from the following medicinal materials in parts by weight: 5-15 parts of angelica dahurica, 3-10 parts of asarum, 3-10 parts of cinnamon, 5-15 parts of centipeda minima and 3-10 parts of borneol.
Further, in a preferred embodiment of the present invention, the traditional Chinese medicine composition is prepared from the following medicinal materials in parts by weight: 8-12 parts of angelica dahurica, 4-8 parts of asarum, 4-8 parts of cinnamon, 8-12 parts of centipeda minima and 4-8 parts of borneol.
Further, in a preferred embodiment of the present invention, the traditional Chinese medicine composition is prepared from the following medicinal materials in parts by weight: 10 parts of angelica dahurica, 5 parts of asarum, 5 parts of cinnamon, 10 parts of centipeda minima and 5 parts of borneol.
In a second aspect, the invention provides a medicament for treating rhinitis of children, which comprises the traditional Chinese medicine composition.
Further, in a preferred embodiment of the present invention, the above-mentioned dosage form comprises a paste.
In a third aspect, the invention provides a preparation method of a medicament for treating rhinitis of children, which comprises the steps of selecting angelica dahurica, asarum, cinnamon and centipeda minima according to a proportion, drying, crushing, adding borneol and water for mixing uniformly;
further, in a preferred embodiment of the present invention, after the step of blending and homogenizing, a sterilization step is further included, wherein the sterilization temperature is 121-130 ℃.
Further, in a preferred embodiment of the present invention, the weight of the water is 10% to 20% of the total weight of the dahurian angelica root, the asarum, the cinnamon, the centipeda minima and the borneol.
Further, in a preferred embodiment of the present invention, the drying temperature is 50 to 60 ℃.
Furthermore, in a preferred embodiment of the present invention, the above-mentioned radix angelicae dahuricae, asarum herb, cinnamon bark and centipeda minima are pulverized into particles with a size of 100-120 meshes.
Compared with the prior art, the invention at least has the following technical effects:
the traditional Chinese medicine pathology of the chronic rhinitis of children is that the chronic rhinitis of children is caused by the failure of lung qi and the insecurity of defensive yang, so that the chronic rhinitis of children is easily attacked by wind-cold evil and the lung loses the function of clearing and descending, so that nasal orifices are obstructed, and the chronic rhinitis of children is treated as rhinitis. The traditional Chinese medicine composition is prepared by the synergistic effect of monarch drug angelica dahurica, ministerial drugs asarum and centipeda minima, and adjuvant drug cinnamon and messenger drug borneol.
Wherein the monarch drug angelica dahurica is pungent in nature and flavor, warm in nature and enters lung meridian. Has the efficacies of dispelling wind and relieving exterior syndrome, is also a key medicine for treating nasosinusitis, and has the functions of resolving dampness and dredging nasal orifices. Aiming at the pathogenesis of the chronic rhinitis of children, the traditional Chinese medicine composition has the functions of dispelling wind cold of lung and recovering the clearing and purifying function of lung, thereby having the functions of dredging nasal orifices and relieving the rhinitis.
The ministerial drugs are asarum and centipeda minima, and the asarum has pungent and warm flavor and enters lung channels. Has effects of dispelling pathogenic wind and cold, dispelling pathogenic wind, warming lung, and eliminating phlegm. The asarum can not only externally disperse wind-cold but also internally dispel yin-cold, and assists the monarch drug of angelica dahurica to strengthen the effects of strengthening defensive yang and dispersing lung wind-cold. Centipeda minima, pungent in nature and taste and warm in nature, enters lung meridian. Dispersing wind-cold, dredging nasal orifice, assisting monarch drug radix Angelicae Dahuricae, strengthening and recovering lung function, dredging nasal orifice, and relieving rhinitis.
The cinnamon is pungent, sweet and big-heat in nature and has the effects of warming middle-jiao and tonifying yang, and dispelling cold and relieving pain. On the one hand, the effects of strengthening defensive yang and dispersing lung wind-cold of angelica dahurica and asarum are assisted and strengthened. On the other hand, the skin of the local acupuncture points is stimulated, the effects of stimulating the acupuncture points and warming and dredging the channels and collaterals are achieved, and the monarch and minister drugs are enabled to play a role in stimulating the acupuncture points.
The conductant drug is borneol, the borneol is pungent and fragrant, and can dredge the orifices, enhance the transdermal effect of acupoint stimulation on one hand, and assist monarch and minister drugs in dredging nasal orifices on the other hand.
The compatibility of the monarch, the minister, the assistant and the guide selects natural traditional Chinese medicine raw materials, the prepared traditional Chinese medicine composition has no toxic or side effect, is economical and practical, follows the prescription and medication principle of the traditional Chinese medicine, and is proved by clinical application to have obvious curative effect and can obviously reduce the recurrence rate of the disease. The prepared Chinese medicinal composition is directly pasted on corresponding acupuncture points, so that the effects of enhancing the resistance of children and strengthening defensive yang are achieved, and the rhinitis of children is prevented and treated.
The invention provides a medicament for treating rhinitis of children, which can meet the medicinal requirements of children patients by obtaining simple paste.
The preparation method of the medicament for treating the rhinitis of children provided by the invention selects natural traditional Chinese medicine raw materials, is simple in preparation method and convenient to operate, and can realize industrial production without purchasing expensive equipment.
Drawings
FIG. 1 is a schematic view of a Visual Analogue Scoring (VAS) method for nasal congestion symptoms according to embodiment 5 of the present invention
Detailed Description
Embodiments of the present invention will be described in detail with reference to the following examples, but those skilled in the art will understand that the following examples are merely illustrative of the present invention and should not be construed as limiting the scope of the present invention, and that the specific conditions not specified in the examples are carried out according to conventional conditions or conditions suggested by the manufacturer, and that the reagents or equipment used are not specified by the manufacturer, and are all conventional products available through commercial purchase.
The technical scheme of the specific implementation mode of the invention is as follows:
the invention provides a traditional Chinese medicine composition for treating rhinitis of children, which is prepared from the following medicinal materials in parts by weight: 5-15 parts of angelica dahurica, 3-10 parts of asarum, 3-10 parts of cinnamon, 5-15 parts of centipeda minima and 3-10 parts of borneol.
Further, the traditional Chinese medicine composition is prepared from the following medicinal materials in parts by weight: 8-12 parts of angelica dahurica, 4-8 parts of asarum, 4-8 parts of cinnamon, 8-12 parts of centipeda minima and 4-8 parts of borneol.
Further, the traditional Chinese medicine composition is prepared from the following medicinal materials in parts by weight: 10 parts of angelica dahurica, 5 parts of asarum, 5 parts of cinnamon, 10 parts of centipeda minima and 5 parts of borneol.
The invention also provides a medicament for treating rhinitis of children, which comprises the traditional Chinese medicine composition.
Further, the above dosage forms include ointments. The purpose is to meet the medicinal requirements of different patients through the ointment.
Furthermore, the above ointment can be administered by placing the ointment on a sticky patch, and applying the patch containing the ointment to Feishu acupoint, dingchuan acupoint, tiantu acupoint and Zusanli acupoint.
Through long-term test trials, the combination of the ointment and the acupuncture points finally discovers that the acupuncture points of Feishu acupuncture point, dingchuan acupuncture point, tiantu acupuncture point and Zusanli acupuncture point are combined with the rhinitis ointment, and the rhinitis ointment has obvious effect of treating the rhinitis of children.
Of the above-mentioned acupoints, the main acupoint is Feishu acupoint, which belongs to the bladder meridian of foot Taiyang and the back Shu acupoint of lung, and the main diseases are: the lung meridian and respiratory tract diseases play a role in treating chronic rhinitis and recovering the clearing and purifying functions of the lung.
The auxiliary points are asthma-relieving and Tiantu, the asthma-relieving point is an extra-channel point, the Tiantu point belongs to the ren channel, the two points are commonly used points for treating lung diseases and abnormal lung qi clearing and purifying functions, and the auxiliary main points play the roles of ventilating the lung, regulating the flow of qi and treating rhinitis.
The foot sanli matching point is one of the main points of the stomach channel of foot yangming, and has the functions of strengthening the physique of children, strengthening defensive yang and preventing repeated attack of chronic rhinitis.
The maximum curative effect of the medicine can be better exerted by the action of the medicine and the specific acupuncture points.
The thickness of the ointment is 3-10 mm. The rhinitis ointment aims to be applied too much and easily cause unnecessary waste, but the effect of the rhinitis ointment is affected by too little application.
The invention provides a preparation method of a medicament for treating rhinitis of children, which comprises the steps of selecting dahurian angelica root, asarum, cinnamon and centipeda minima according to a proportion, drying, crushing, adding borneol and water for blending uniformly.
The traditional Chinese medicine composition prepared by the method has the advantages of easily-obtained raw material selection and simple preparation method, and the final composition can be obtained only by crushing, adding borneol and a solvent and then preparing into a paste.
Further, after the step of blending and homogenizing, the method also comprises a step of sterilizing, wherein the sterilizing temperature is 121-130 ℃. The aim is to ensure the sanitation and convenient long-term preservation of the ointment through the sterilization temperature.
Further, the weight of the water is 10-20% of the total weight of the angelica dahurica, the asarum, the cinnamon, the centipeda minima and the borneol. The purpose of the range of water weight is to ensure that the drug concentration of the ointment is within an effective range and the ointment is shaped.
Further, the drying temperature is 50-60 ℃. The aim is to ensure the formation of a paste without being too hard or too soft.
Further, the radix angelicae dahuricae, the asarum, the cinnamon and the centipeda minima are crushed to have the particle size of 100-120 meshes. The purpose is to ensure the texture of the ointment, is favorable for good contact feeling of skin contact, and plays an effective acupuncture point stimulation role and a drug permeation role.
The following describes in detail specific embodiments of the present invention. It should be understood that the detailed description and specific examples, while indicating the present invention, are given by way of illustration and explanation only, not limitation.
Example 1
The embodiment provides a traditional Chinese medicine composition for treating rhinitis of children, which is prepared from the following medicinal materials in parts by weight of 5 parts of radix angelicae, 3 parts of asarum, 3 parts of cinnamon, 5 parts of centipeda minima and 3 parts of borneol.
The embodiment provides a preparation method of a medicament for treating rhinitis of children, which comprises the steps of selecting the angelica dahurica, the asarum, the cinnamon and the centipeda minima, drying at 50 ℃, crushing after drying, enabling the crushed particles to be 100 meshes, continuously adding the borneol, adding water accounting for 10% of the total weight of the angelica dahurica, the asarum, the cinnamon, the centipeda minima and the borneol, and uniformly mixing to obtain a paste composition.
Example 2
The embodiment provides a traditional Chinese medicine composition for treating rhinitis of children, which is prepared from the following medicinal materials in parts by weight: 15 parts of angelica dahurica, 10 parts of asarum, 10 parts of cinnamon, 15 parts of centipeda minima and 10 parts of borneol.
The embodiment provides a preparation method of a medicament for treating rhinitis of children, which comprises the steps of selecting the angelica dahurica, the asarum, the cinnamon and the centipeda minima, drying at the temperature of 60 ℃, crushing after drying, enabling the crushed particles to be 120 meshes, continuously adding the borneol, adding water accounting for 20% of the total weight of the angelica dahurica, the asarum, the cinnamon, the centipeda minima and the borneol, and uniformly mixing to obtain a paste composition.
Example 3
The embodiment provides a traditional Chinese medicine composition for treating rhinitis of children, which is prepared from the following medicinal materials in parts by weight: 8 parts of angelica dahurica, 4 parts of asarum, 4 parts of cinnamon, 8 parts of centipeda minima and 4 parts of borneol.
The embodiment provides a preparation method of a medicament for treating rhinitis of children, which comprises the steps of selecting the angelica dahurica, the asarum, the cinnamon and the centipeda minima, drying at 55 ℃, crushing after drying, enabling the crushed particles to have a particle size of 110 meshes, continuously adding the borneol, adding water accounting for 15% of the total weight of the angelica dahurica, the asarum, the cinnamon, the centipeda minima and the borneol, and uniformly mixing to obtain a paste composition.
Example 4
The embodiment provides a traditional Chinese medicine composition for treating rhinitis of children, which is prepared from the following medicinal materials in parts by weight: 12 parts of angelica dahurica, 8 parts of asarum, 8 parts of cinnamon, 12 parts of centipeda minima and 8 parts of borneol.
The embodiment provides a preparation method of a medicament for treating rhinitis of children, which comprises the steps of selecting the angelica dahurica, the asarum, the cinnamon and the centipeda minima, drying at 52 ℃, crushing after drying, enabling the crushed particles to have a particle size of 110 meshes, continuously adding the borneol, adding water accounting for 18% of the total weight of the angelica dahurica, the asarum, the cinnamon, the centipeda minima and the borneol, and uniformly mixing to obtain a paste composition.
Example 5
The embodiment provides a traditional Chinese medicine composition for treating rhinitis of children, which is prepared from the following medicinal materials in parts by weight: 10 parts of angelica dahurica, 5 parts of asarum, 5 parts of cinnamon, 10 parts of centipeda minima and 5 parts of borneol.
The embodiment provides a preparation method of a medicament for treating rhinitis of children, which comprises the steps of selecting the angelica dahurica, the asarum, the cinnamon and the centipeda minima, drying at the temperature of 58 ℃, crushing after drying, enabling the crushed particles to be 120 meshes, continuously adding the borneol, adding water accounting for 14% of the total weight of the angelica dahurica, the asarum, the cinnamon, the centipeda minima and the borneol, and uniformly mixing to obtain a paste composition.
Example 6
The embodiment provides a traditional Chinese medicine composition for treating rhinitis of children, which is prepared from the following medicinal materials in parts by weight: 7 parts of angelica dahurica, 6 parts of asarum, 6 parts of cinnamon, 7 parts of centipeda minima and 6 parts of borneol.
The embodiment provides a preparation method of a medicament for treating rhinitis of children, which comprises the steps of selecting the angelica dahurica, the asarum, the cinnamon and the centipeda minima, drying at 56 ℃, crushing after drying, enabling the crushed particles to be 100 meshes, continuously adding the borneol, adding water accounting for 15% of the total weight of the angelica dahurica, the asarum, the cinnamon, the centipeda minima and the borneol, and uniformly mixing to obtain a paste composition.
In order to demonstrate that the traditional Chinese medicine composition provided by the application has the effect of improving and treating rhinitis, the following experiments are carried out:
140 cases of children with chronic rhinitis are selected from 1-12 months and 4 primary department hospital in 2021, and are divided into an experimental group and a control group according to a random number method, wherein each group comprises 70 cases, the control group simply adopts the existing Chinese patent medicines, and the product name is as follows: xinqin granules, nanjing Tongrentang pharmaceutical finite responsibility company, national Standard Z32020020, in the specification of 20g and 20mg per bag, are used at a dose of 2 times per day. Experimental group the ointment prepared in this example 5 was applied to sticky patches by the acupoint application therapy on the basis of the control group, and the patches containing the ointment were applied to feishu, dingchuan, tiantu and zusanli acupoints for a treatment period of 4 weeks, and the results showed that: the nasal obstruction, nasal itching, running nose score and total symptom score difference of the children patients in the experimental group and the control group have statistical significance (P is less than 0.05). Compared with the total effective rate, the difference has statistical significance (P < 0.05).
TABLE 1 evaluation chart for nasal obstruction, rhinocnesmus, rhinorrhoea and overall discomfort of experimental group and control group
The symptoms are evaluated by Visual Analogue Scoring (VAS), as shown in figure 1
The nasal itching, nasal discharge and overall discomfort are all consistent with nasal obstruction scoring standard
TABLE 2 effective rate of the treatment effect of the experimental group and the control group
| Rate of recovery | Display efficiency | Effective rate of | Inefficiency of | Total effective rate | |
| |
9 persons, 13.64% | 34 persons, 51.52% | 20 persons, 30.30% | 3 persons, 4.55% | 95.45 |
| Control group | |||||
| 1 human, 1.67% | 10 people, 16.675 | 40 persons, 66.67% | 9 persons, 15.00% | 85.00％ |
The curative effect is judged, the clinical symptoms are completely disappeared, and no relapse occurs after 6 months of observation after the medicine is stopped;
the effect is obvious, the clinical symptoms are obviously improved, and the relapse is 1 time after the medicine is stopped and observed for 6 months;
the method has the following advantages: the clinical symptoms are improved, and the disease recurs for 2 times in 6 months after the medicine is stopped;
no effect, no obvious change of clinical symptoms, even aggravation.
Finally, it should be noted that: the above description is only a preferred embodiment of the present invention, and is not intended to limit the scope of the present invention. Any modification, equivalent replacement, or improvement made within the spirit and principle of the present invention should be included in the protection scope of the present invention.
Claims (10)
1. The traditional Chinese medicine composition for treating rhinitis of children is characterized by being prepared from the following medicinal materials in parts by weight: 5-15 parts of angelica dahurica, 3-10 parts of asarum, 3-10 parts of cinnamon, 5-15 parts of centipeda minima and 3-10 parts of borneol.
2. The traditional Chinese medicine composition for treating rhinitis of children as claimed in claim 1, wherein the traditional Chinese medicine composition is prepared from the following medicinal materials in parts by weight: 8-12 parts of angelica dahurica, 4-8 parts of asarum, 4-8 parts of cinnamon, 8-12 parts of centipeda minima and 4-8 parts of borneol.
3. The traditional Chinese medicine composition for treating rhinitis of children according to claim 2, which is prepared from the following medicinal materials in parts by weight: 10 parts of angelica dahurica, 5 parts of asarum, 5 parts of cinnamon, 10 parts of centipeda minima and 5 parts of borneol.
4. A medicament for treating rhinitis in children, which comprises the traditional Chinese medicine composition as claimed in any one of claims 1 to 3.
5. The medicament of claim 4, wherein the dosage form comprises a paste.
6. A method for preparing the medicament for treating rhinitis of children as claimed in any one of claims 4-5, wherein radix Angelicae Dahuricae, herba asari, cortex Cinnamomi and herba Centipedae are selected proportionally, dried, pulverized, and mixed with Borneolum Syntheticum and water to obtain a uniform mixture.
7. The method for preparing a medicament for treating rhinitis in children according to claim 6, further comprising a sterilization step after the step of uniformly blending, wherein the sterilization temperature is 121-130 ℃.
8. The method for preparing a medicament for treating rhinitis in children according to claim 6, wherein the weight of the water is 10% -20% of the total weight of radix Angelicae Dahuricae, herba asari, cortex Cinnamomi, herba Centipedae and Borneolum Syntheticum.
9. The method for preparing a medicament for treating rhinitis in children according to claim 6, wherein the drying temperature is 50-60 ℃.
10. The method for preparing a medicament for treating rhinitis in children according to claim 6, wherein the radix angelicae dahuricae, asarum herb, cinnamon bark and centipeda minima are crushed to have a particle size of 100-120 meshes.
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