CN112190534A - 一种防脱洗发水及其制备方法和应用 - Google Patents
一种防脱洗发水及其制备方法和应用 Download PDFInfo
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- CN112190534A CN112190534A CN202011149871.1A CN202011149871A CN112190534A CN 112190534 A CN112190534 A CN 112190534A CN 202011149871 A CN202011149871 A CN 202011149871A CN 112190534 A CN112190534 A CN 112190534A
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Abstract
本发明涉及日用品技术领域，具体来说是一种防脱洗发水及其制备方法和应用。由组方中药和洗发水基质制成，所述组方中药由如下重量份数的原料组成：黑枸杞8‑15份、沙棘籽2‑7份、益生菌5‑9份、纳豆10‑16份、番茄6‑11份、黄精3‑8份、何首乌7‑11份、葛根4‑8份、生姜2‑5份、人参2‑5份、雪莲1‑4份、松花2‑3份、虫草0.5‑1份。本发明采用副作用低、对皮肤影响较小的的中药材以主要原料，对脂溢性脱发进行针对性治疗，根据君、臣、佐、使的中医思想，以通、调、排、补组方中药为主要功效添加剂，辅以洗发水中常用基质成分配制而成的中药防脱洗发水。
Description
技术领域
本发明涉及日用品技术领域，具体来说是一种防脱洗发水及其制备方法和应用。
背景技术
脂溢性脱发是在皮脂溢出过多的基础上发生的一种脱发，常伴有头屑增多，头皮油腻，痛痒明显。多发生于皮脂腺分泌旺盛的青壮年，头发细软，有的伴有头皮脂溢性皮炎，开始逐渐自头顶部开始胶发，最后蔓延及额部。头皮油腻而亮红，结黄色油性痂。溢脂性脱发的治疗须首先注重头发的保健护理，少食油腻及辛辣食物，勤于洗头，局部用药去除油脂，减少皮屑，消炎止痒，其次需对身体进行调理。
中药对脱发的外治主要是将中药制成生发的酊剂，使药物直接作用于患处,对局部起一定刺激作用，从而促进局部皮肤的血液循环，改善毛发营养，促进毛发生长和药物吸收，经过透皮吸收，亦可产生全身作用。一般最初效果表现为固发，即停止脱发或脱发减少，随后出现生发、长发，即先生出毳毛样发，再逐渐变为终毛，或毳毛样发逐渐变黑、粗、硬、长。另对头皮瘙痒、头屑、皮脂过多都有不同程度的治疗作用。
发明内容
针对上述存在的技术不足，本发明的目的是提供了一种防脱洗发水及其制备方法和应用，本发明采用副作用低、对皮肤影响较小的的中药材以主要原料，对脂溢性脱发进行针对性治疗，根据君、臣、佐、使的中医思想，以组方中药提取物为主要功效添加剂，辅以洗发水中常用基质成分配制而成的中药防脱洗发水。
为解决上述技术问题，本发明采用如下技术方案：
一种防脱洗发水，由组方中药和洗发水基质制成，所述组方中药由如下重量份数的原料组成：黑枸杞8-15份、沙棘籽2-7份、益生菌5-9份、纳豆10-16份、番茄6-11份、黄精3-8份、何首乌7-11份、葛根4-8份、生姜2-5份、人参2-5份、雪莲1-4份、松花2-3份、虫草0.5-1份；
所述洗发水基质由如下重量份数的原料组成：柠檬酸0.04-0.08份、硬脂酸乙二醇双脂0.10-0.15份、椰油酰胺MEA 0.15-0.25份，增稠剂0.1-0.2份；山梨酸钾0.08-0.12份；乙二胺四乙酸二钠0.02-0.04份；CA-35发泡剂0.04-0.08份；
洗发水基质与组方中药的质量百分比比例为65-75：25-35，二者的质量百分比之和为100％。
优选的，所述组方中药由如下重量份数的原料制成：黑枸杞10-13份、沙棘籽3-6份、益生菌6-8份、纳豆12-15份、番茄7-9份、黄精5-7份、何首乌8-10份、葛根5-7份、生姜3-4份、人参3-5份、雪莲2-4份、松花2.3-2.8份、虫草0.6-0.9份。
优选的，所述组方中药由如下重量份数的原料制成：黑枸杞12份、沙棘籽5份、益生菌7份、纳豆14份、番茄8份、黄精6份、何首乌9份、葛根6份、生姜3.5份、人参4份、雪莲3份、松花2.5份、虫草0.8份。
优选的，所述增稠剂为果胶、透明质酸钠、羧甲基纤维素或纤维素胶中的一种。
本发明还保护了一种防脱洗发水的制备方法，包括如下步骤：
(1)按照如下重量份数称取各原料：黑枸杞8-15份、沙棘籽2-7份、益生菌5-9份、纳豆10-16份、番茄6-11份、黄精3-8份、何首乌7-11份、葛根4-8份、生姜2-5份、人参2-5份、雪莲1-4份、松花2-3份、虫草0.5-1份，备用；
(2)将黄精经过九蒸九制后，切割剁碎后，得到处理黄精；
(3)将沙棘籽和番茄分别经过压榨，并得到的沙棘籽油和番茄汁；
(4)将黑枸杞、纳豆、何首乌、葛根、生姜、人参、雪莲、松花和虫草混合并粉碎后，与步骤(2)的处理黄精混合，然后经水提得到水提物，再将水提物浓缩，得到浸膏；
(5)将步骤(3)的沙棘籽油和番茄汁、步骤(4)的浸膏、益生菌及洗发水基质混合，得到共混物，将共混物共同加入至鲸蜡醇水溶液中并混合均匀，调节pH至7.2-7.8，得到防脱洗发水；
其中，共混物与鲸蜡醇水溶液的质量之比为20-30：100，共混物中洗发水基质的重量百分比为65-75％，鲸蜡醇水溶液的质量分数为1.5-5％。
优选的，在所述步骤(5)中先将番茄汁和浸膏经活性炭吸附脱色后再与益生菌及洗发水基质混合。
本发明还保护了一种防脱洗发水在做为防脱控油功效的护发制剂中的应用。
与现有技术相比，本发明具有的有益效果是：
黑枸杞：清除皮肤有害物质自由基的堆积和沉淀，黑枸杞中花青素的多羟基结构使其具有较强的清除自由基，从而抑制氧化损伤，提高皮肤的抵抗力、免疫力和抗辐射能力；
沙棘籽：沙棘油是从天然植物沙棘的果实当中提取出来的天然的油脂，它里边除了含有不饱和脂肪酸以外，还含有黄酮、维生素、微量元素等一百多种生物活性物质，；
益生菌：快速到达问题发质，重新调理平衡头皮菌群，清除皮肤有害物质的堆积和沉淀，维护头皮一个健康的微生态，从而达到防脱发的一个很好的效果；
何首乌：何首乌的用药部位是块根，性味苦、甘、涩、微温，归肝、心、肾经，有解毒、消痈、截疟、润肠通便的功效；
葛根：葛根有发表解肌，升阳透疹，解热生津的功效；
生姜：促进血液循环，也具有“发汗”的作用，有助于人通过血液和汗腺将毒素排出体外；
人参：具有大补元气、复脉固脱、补脾益肺、生津及安神之效；
雪莲：雪莲中含有氨基酸、维生素、糖分、矿物质及生物酶等活性物质，具有补肾阳、祛风除湿、强筋骨之效；
松花：具有助阳益阴，散寒，调理脏腑，暖肾健脾，疏通经络，舒筋活血，扶正补虚，延年益寿的作用；
虫草：冬虫夏草补益肺肝肾，调节人体免疫力，提高人体抗病以及恢复的能力。
本发明根据君、臣、佐、使的中医思想，以组方中药提取物为主要功效添加剂，辅以洗发水中常用基质成分配制而成的中药防脱洗发水。君、臣、佐、使的中医思想体现在本申请的洗发水中主要表现为通、调、排、补，以黑枸杞、沙棘籽和益生菌为君药，以达到疏通毛囊的目的；以纳豆、番茄和黄精为臣药，以达到调气血的目的；以何首乌、葛根和生姜为佐药，以达到排热毒的目的；以人参、雪莲、松花和虫草为使药，以达到补肾气的目的。
本发明以通、调、排、补为发明构思，通：疏通毛囊，毛囊疏通后头发就会进行生长，通过黑枸杞、沙棘籽和益生菌进行毛囊疏通；黑枸杞清除皮肤有害物质自由基的堆积和沉淀、提高皮肤的抵抗力、免疫力和抗辐射能力，益生菌重新调理平衡头皮菌群，维护头皮一个健康的微生态，从而达到防脱发的一个很好的效果；沙棘籽中的沙棘油保护头皮健康，辅助疏通毛囊；
调：调气血，发为气血之余，气血充足之后，促进头发生长，通过使用纳豆、番茄和黄精调气血；辅助君药作用；
排：排热毒，体内毒素排出之后，毛囊也疏通了，头发就会生长，以何首乌、葛根和生姜排热毒，何首乌解毒、消痈、截疟、润肠通便，葛根发表解肌，升阳透疹，解热生津，生姜促进血液循环，有助于人通过血液和汗腺将毒素排出体外；辅助君药和臣药；
补：补肾气，肾虚引起脱发，补充肾气促进头发生长；通过人参、雪莲、松花和虫草补肾气；人参复脉固脱、补脾益肺，雪莲补肾阳、祛风除湿、强筋骨，松花助阳益阴，虫草益肺肝肾，调节人体免疫力，四者共奏实现肾气的增补，克服肾气不足的引起脱发。
本发明制得的防脱洗发水采用天然温和、安全无刺激的中药材，并极易被皮肤吸收，具有疏通毛囊、调气血、排热毒、补肾气的作用，通过标本兼治的原理达到防止头发脱落、促进毛发生长及头皮控油的功效。
本发明的防脱洗发水还包括了洗发水基质，洗发水基质中的柠檬酸为助剂，维持头皮酸碱平衡，硬脂酸乙二醇双脂，能增加产品的粘度，还具有滋润皮肤、养发护发和抗静电作用，椰油酰胺MEA做为乳化剂，山梨酸钾做为防腐剂同时调节酸碱度；乙二胺四乙酸二钠做为络合剂；CA-35做为发泡剂。
具体实施方式
下面结合本发明实施例，用以较佳的实施例配合详细的说明。
实施例1
一种防脱洗发水的制备方法，包括如下步骤：
(1)按照如下重量份数称取各原料：黑枸杞8份、沙棘籽7份、益生菌9份、纳豆10份、番茄6份、黄精3份、何首乌11份、葛根4份、生姜2份、人参5份、雪莲4份，松花3份、虫草0.5份，备用；
(2)将黄精经过九蒸九制后，切割剁碎后，得到处理黄精；
(3)将沙棘籽和番茄分别经过压榨，并得到的沙棘籽油和番茄汁；
(4)将黑枸杞、纳豆、何首乌、葛根、生姜、人参、雪莲、松花和虫草混合并粉碎后，与步骤(2)的处理黄精混合，然后经水提得到水提物，再将水提物浓缩，得到浸膏；
(5)将步骤(3)的沙棘籽油和番茄汁、步骤(4)的浸膏、益生菌及洗发水基质混合，洗发水基质均质共混，得到共混物，将共混物共同加入至1.5％鲸蜡醇水溶液中并混合均匀，共混物与鲸蜡醇水溶液的质量之比为20：100，调节pH至7.2，共混物中洗发水基质的重量份数为65％，得到防脱洗发水。
实施例2
一种防脱洗发水的制备方法，包括如下步骤：
(1)按照如下重量份数称取各原料：黑枸杞13份、沙棘籽3份、益生菌6份、纳豆12份、番茄9份、黄精7份、何首乌8份、葛根5份、生姜4份、人参3份、雪莲4份，松花2.3份，虫草0.9份，备用；
(2)将黄精经过九蒸九制后，切割剁碎后，得到处理黄精；
(3)将沙棘籽和番茄分别经过压榨，并得到的沙棘籽油和番茄汁；
(4)将黑枸杞、纳豆、何首乌、葛根、生姜、人参、雪莲、松花和虫草混合并粉碎后，与步骤(2)的处理黄精混合，然后经水提得到水提物，再将水提物浓缩，得到浸膏；
(5)将步骤(3)的沙棘籽油和番茄汁、步骤(4)的浸膏、益生菌及洗发水基质混合，洗发水基质均质共混，得到共混物，将共混物共同加入至2％鲸蜡醇水溶液中并混合均匀，共混物与鲸蜡醇水溶液的质量之比为23：100，调节pH至7.4，共混物中洗发水基质的重量份数为68％，得到防脱洗发水。
实施例3
一种防脱洗发水的制备方法，包括如下步骤：
(1)按照如下重量份数称取各原料：黑枸杞12份、沙棘籽5份、益生菌7份、纳豆14份、番茄8份、黄精6份、何首乌9份、葛根6份、生姜3.5份、人参4份、雪莲3份、松花2.5份、虫草0.8份，备用；
(2)将黄精经过九蒸九制后，切割剁碎后，得到处理黄精；
(3)将沙棘籽和番茄分别经过压榨，并得到的沙棘籽油和番茄汁；
(4)将黑枸杞、纳豆、何首乌、葛根、生姜、人参、雪莲、松花和虫草混合并粉碎后，与步骤(2)的处理黄精混合，然后经水提得到水提物，再将水提物浓缩，得到浸膏；
(5)将步骤(3)的沙棘籽油和番茄汁、步骤(4)的浸膏、益生菌及洗发水基质混合，洗发水基质均质共混，得到共混物，将共混物共同加入至3％鲸蜡醇水溶液中并混合均匀，共混物与鲸蜡醇水溶液的质量之比为25：100，调节pH至7.5，共混物中洗发水基质的重量份数为70％，得到防脱洗发水。
实施例4
一种防脱洗发水的制备方法，包括如下步骤：
(1)按照如下重量份数称取各原料：黑枸杞10份、沙棘籽6份、益生菌8份、纳豆15份、番茄7份、黄精5份、何首乌10份、葛根7份、生姜3份、人参5份、雪莲2份、松花2.8份、虫草0.6份，备用；
(2)将黄精经过九蒸九制后，切割剁碎后，得到处理黄精；
(3)将沙棘籽和番茄分别经过压榨，并得到的沙棘籽油和番茄汁；
(4)将黑枸杞、纳豆、何首乌、葛根、生姜、人参、雪莲、松花和虫草混合并粉碎后，与步骤(2)的处理黄精混合，然后经水提得到水提物，再将水提物浓缩，得到浸膏；
(5)将步骤(3)的沙棘籽油和番茄汁、步骤(4)的浸膏、益生菌及洗发水基质混合，洗发水基质均质共混，得到共混物，将共混物共同加入至4％鲸蜡醇水溶液中并混合均匀，共混物与鲸蜡醇水溶液的质量之比为28：100，调节pH至7.6，共混物中洗发水基质的重量份数为72％，得到防脱洗发水。
实施例5
一种防脱洗发水的制备方法，包括如下步骤：
(1)按照如下重量份数称取各原料：黑枸杞15份、沙棘籽2份、益生菌5份、纳豆16份、番茄11份、黄精8份、何首乌7份、葛根8份、生姜5份、人参2份、雪莲1份、松花2份、虫草1份，备用；
(2)将黄精经过九蒸九制后，切割剁碎后，得到处理黄精；
(3)将沙棘籽和番茄分别经过压榨，并得到的沙棘籽油和番茄汁；
(4)将黑枸杞、纳豆、何首乌、葛根、生姜、人参、雪莲、松花和虫草混合并粉碎后，与步骤(2)的处理黄精混合，然后经水提得到水提物，再将水提物浓缩，得到浸膏；
(5)将步骤(3)的沙棘籽油和番茄汁、步骤(4)的浸膏、益生菌及洗发水基质混合，洗发水基质均质共混，得到共混物，将共混物共同加入至5％鲸蜡醇水溶液中并混合均匀，共混物与鲸蜡醇水溶液的质量之比为30：100，调节pH至7.8，共混物中洗发水基质的重量份数为75％，得到防脱洗发水。
本发明均制备得到了针对脂溢性脱发有效的防脱洗发水，且防脱发效果平行，下面以实施例3制得的防脱洗发水为例进行研究，具体研究方法如下：
将本发明制得的防脱洗发水进行卫生指标认证，其质量完全符合QB/T1974-2004洗发液(膏)的要求，其理化指标如表1所示：
本发明的防脱洗发水经过急性皮肤刺激性试验得出无刺激性；急性眼刺激性实验，为正常轻微刺激性；皮肤光毒性实验，未见皮肤光毒性。
二、临床实验
选取脂溢性脱发人群，设计实验组和对照组，每组30人，实验组使用本发明的实施例3的防脱洗发水，对照组使用试用市售的洗发水，进行次数和用量相同的洗发，3天洗发一次，使用30天。
观察两组人群试用前后的脱发情况、头皮油脂分泌情况以及去屑情况，具体结果如下：
表2洗发水使用效果比较
“防脱发情况”的很好为毛发停止脱落，脱发再生达70％以上；较好为脱发现象减轻，头顶毛发增多，脱发再生达30％以上；不明显为脱发现象和头顶毛发量无明显变化，脱发再生不足30％或仍继续脱落；
“控油持久性”的很好为清洗后4天无明显出油状况；较好为清洗后3天无明显出油状况；不明显为清洗后第二天明显出油；
“去屑情况”的很好为肉眼不见头皮屑，头皮舒适；较好为头皮屑量减少，轻微瘙痒；不明显为头皮屑量和瘙痒症状未得到任何改善；
对比来看，在防脱发、控油、控油持久性和去屑情况使用的调查中显示：本发明的防脱洗发水的使用效果更好，得到了认可，且相比于现有技术市售的防脱洗发水更加优异。
脱发药效实验
1、实验材料
(1)动物
Wistar大鼠，雌雄各半，体重200-250g；
(2)药品与试剂
本发明实施例1-5的样品，生理盐水，3％苦味酸溶液，丙酸睾丸酮注射液；
(3)实验分组
将Wistar大鼠随机分为6组：实施例1-5组和空白对照组，实验组为实施例1-5组，空白对照组为清水组，每组10只，雌雄各半，共60只。
(4)造模
造模方法：每日灌胃给予等体积生理盐水，并于颈后皮下注射丙酸睾丸酮注射液5mg/(kg·d)，1次/日，造模和给药4周后，将大鼠单独饲养，并将大鼠脱落的毛发收集后用3％苦味酸溶液染色，便于计数；
(5)实验和实验方法
实验方法：采用实施例1-实施例5的样品及空白对照组的清水分别每日对造模大鼠进行清洗，对脱落的毛发染色后进行计量并对大鼠脱毛区况并记录，记录1日、7日和14日的情况并进行对比，结果表3和表4所示；
表3对大鼠毛发脱落数量的影响
表4对大鼠脱毛区脱毛状况的影响
结果表明：与空白对照组相比，本发明的实施例组对注射丙酸睾丸酮注射液导致脱毛发大鼠有积极显著的止脱发作用，且能够有效治疗脱发的情况。
显然，本领域的技术人员可以对本发明进行各种改动和变型而不脱离本发明的精神和范围。这样，倘若本发明的这些修改和变型属于本发明权利要求及其等同技术的范围之内，则本发明也意图包含这些改动和变型在内。
Claims (7)
1.一种防脱洗发水，其特征在于，由组方中药和洗发水基质制成，所述组方中药由如下重量份数的原料制成：黑枸杞8-15份、沙棘籽2-7份、益生菌5-9份、纳豆10-16份、番茄6-11份、黄精3-8份、何首乌7-11份、葛根4-8份、生姜2-5份、人参2-5份、雪莲1-4份、松花2-3份、虫草0.5-1份；
所述洗发水基质由如下重量份数的原料组成：柠檬酸0.04-0.08份、硬脂酸乙二醇双脂0.10-0.15份、椰油酰胺MEA 0.15-0.25份，增稠剂0.1-0.2份；山梨酸钾0.08-0.12份；乙二胺四乙酸二钠0.02-0.04份；CA-35发泡剂0.04-0.08份；
洗发水基质与组方中药的质量百分比比例为65-75：25-35，二者的质量百分比之和为100％。
2.根据权利要求1所述的一种防脱洗发水，其特征在于，所述组方中药由如下重量份数的原料制成：黑枸杞10-13份、沙棘籽3-6份、益生菌6-8份、纳豆12-15份、番茄7-9份、黄精5-7份、何首乌8-10份、葛根5-7份、生姜3-4份、人参3-5份、雪莲2-4份、松花2.3-2.8份、虫草0.6-0.9份。
3.根据权利要求1所述的一种防脱洗发水，其特征在于，所述组方中药由如下重量份数的原料制成：黑枸杞12份、沙棘籽5份、益生菌7份、纳豆14份、番茄8份、黄精6份、何首乌9份、葛根6份、生姜3.5份、人参4份、雪莲3份、松花2.5份、虫草0.8份。
4.根据权利要求1所述的一种防脱洗发水，其特征在于，所述增稠剂为果胶、透明质酸钠、羧甲基纤维素或纤维素胶中的一种。
5.根据权利要求1-4任一所述的一种防脱洗发水的制备方法，其特征在于，包括如下步骤：
(1)按照如下重量份数称取各原料：黑枸杞8-15份、沙棘籽2-7份、益生菌5-9份、纳豆10-16份、番茄6-11份、黄精3-8份、何首乌7-11份、葛根4-8份、生姜2-5份、人参2-5份、雪莲1-4份、松花2-3份、虫草0.5-1份，备用；
(2)将黄精经过九蒸九制后，切割剁碎后，得到处理黄精；
(3)将沙棘籽和番茄分别经过压榨，并得到的沙棘籽油和番茄汁；
(4)将黑枸杞、纳豆、何首乌、葛根、生姜、人参、雪莲、松花和虫草混合并粉碎后，与步骤(2)的处理黄精混合，然后经水提得到水提物，再将水提物浓缩，得到浸膏；
(5)将步骤(3)的沙棘籽油和番茄汁、步骤(4)的浸膏、益生菌及洗发水基质混合，得到共混物，将共混物共同加入至鲸蜡醇水溶液中并混合均匀，调节pH至7.2-7.8，得到防脱洗发水；
其中，共混物与鲸蜡醇水溶液的质量之比为20-30：100，共混物中洗发水基质的重量百分比为65-75％，鲸蜡醇水溶液的质量分数为1.5-5％。
6.根据权利要求5所述的一种防脱洗发水的制备方法，其特征在于，在所述步骤(5)中先将番茄汁和浸膏经活性炭吸附脱色后再与益生菌及洗发水基质混合。
7.根据权利要求1所述的一种防脱洗发水在做为防脱控油功效的护发制剂中的应用。
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Application publication date: 20210108 |