CN112169014A - Material for promoting rapid repair of skin surface wound by SOD (superoxide dismutase) and preparation method thereof - Google Patents
Material for promoting rapid repair of skin surface wound by SOD (superoxide dismutase) and preparation method thereof Download PDFInfo
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- CN112169014A CN112169014A CN202011030149.6A CN202011030149A CN112169014A CN 112169014 A CN112169014 A CN 112169014A CN 202011030149 A CN202011030149 A CN 202011030149A CN 112169014 A CN112169014 A CN 112169014A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
- A61L26/0014—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
- A61L26/0023—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
- A61L26/0028—Polypeptides; Proteins; Degradation products thereof
- A61L26/0038—Gelatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
- A61L26/0028—Polypeptides; Proteins; Degradation products thereof
- A61L26/0047—Specific proteins or polypeptides not covered by groups A61L26/0033 - A61L26/0042
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0061—Use of materials characterised by their function or physical properties
- A61L26/0066—Medicaments; Biocides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/216—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials with other specific functional groups, e.g. aldehydes, ketones, phenols, quaternary phosphonium groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/252—Polypeptides, proteins, e.g. glycoproteins, lipoproteins, cytokines
- A61L2300/254—Enzymes, proenzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/412—Tissue-regenerating or healing or proliferative agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/45—Mixtures of two or more drugs, e.g. synergistic mixtures
Abstract
The invention relates to the technical field of medical dressings, in particular to a material for promoting rapid repair of skin surface wounds by SOD superoxide dismutase and a preparation method thereof, wherein the material comprises the following components in parts by weight: 0.1-0.2 part of polyacrylic acid, 0.5-1.5 parts of triethanolamine, 2-6 parts of glycerol, 0-20 parts of SOD5, 0-2 parts of vitamin C, 0-20 parts of gelatin, 0-15 parts of sodium alginate and 200 parts of pure water, and the method comprises the following steps: the method comprises the following steps: weighing the materials according to the prescription, adding water, decocting for at least 2 times, filtering, cooling, mixing, filtering, eluting with alcohol, collecting the alcohol eluate, recovering alcohol under reduced pressure, steaming the concentrated solution into viscous gel at 100 deg.C in water bath, and vacuum drying to obtain extract; step two: respectively placing water and the extract in a container, heating to melt the extract, stirring and mixing continuously in one direction at constant temperature, and cooling to obtain the final product; the invention improves the perfection of the skin barrier from the inside and repairs the skin tissue damage by adding SOD and adopting biological synergy and synergy.
Description
Technical Field
The invention relates to the technical field of medical dressings, in particular to a material for promoting rapid repair of skin surface wounds by SOD superoxide dismutase and a preparation method thereof.
Background
The medical dressing is a medical material used for covering sores, wounds or other injuries, and with the deep research on the pathophysiology of the wound healing process, people understand the wound healing process more and more deeply, so that the continuous improvement and development of the medical wound dressing are caused, but the existing medical dressing can not prevent infection, the wound inflammation causes the wound to be repeated, and the healing time is prolonged; meanwhile, the secretion of the wound causes poor healing environment, and the cell growth near the wound needs fresh air environment.
The existing dressing has the following defects that 1, the manufacturing process is complex, the cost is high, blended yarns need to be sized, the weaving process is complicated, the processes of cutting, folding and pasting gauze and the like are needed, multiple devices are needed, the manufacturing cost is high, the gauze containing nano materials can promote wound healing through modification, but the dressing has certain defects in structure, the wound is in direct contact with the gauze, inflammatory secretion permeates into the gauze, the gauze is adhered with the wound surface along with healing of the wound surface, the wound can be ruptured again in the dressing changing process, the healing progress is slowed down, and the infection rate is increased.
Disclosure of Invention
The invention aims to provide a material for promoting wound healing, inhibiting bacteria and resisting inflammation, namely SOD superoxide dismutase and promoting rapid repair of skin surface wounds and a preparation method thereof.
In order to solve the technical problems, the invention adopts the technical scheme that: a material for promoting rapid repair of skin surface wounds by SOD superoxide dismutase comprises the following components in parts by weight:
0.1-0.2 part of polyacrylic acid, 0.5-1.5 parts of triethanolamine, 2-6 parts of glycerol, 0-20 parts of SOD5, 0-2 parts of vitamin C, 0-20 parts of gelatin, 0-15 parts of sodium alginate and 100 parts of pure water.
Further, the paint comprises the following components in percentage by weight:
0.1 part of polyacrylic acid, 1 part of triethanolamine, 4 parts of glycerol, 10 parts of SOD, 1 part of vitamin C, 10 parts of gelatin, 10 parts of sodium alginate and 100 parts of pure water.
Further, the paint comprises the following components in percentage by weight:
polyacrylic acid 0.1 part, triethanolamine 1 part, glycerin 4 parts, SOD10 parts, and pure water 100 parts.
Further, the activity unit of the SOD is 5000U/g.
The method for preparing the material for promoting the rapid repair of the skin surface wound by the SOD superoxide dismutase comprises the following steps:
the method comprises the following steps: weighing the materials according to the prescription, adding water, decocting for at least 2 times, filtering, cooling, mixing, filtering, eluting with alcohol, collecting the alcohol eluate, recovering alcohol under reduced pressure, steaming the concentrated solution into viscous gel at 100 deg.C in water bath, and vacuum drying to obtain extract;
step two: respectively placing water and the extract in a container, heating to melt the extract, stirring and mixing continuously in one direction at constant temperature, and cooling to obtain the final product;
further, in the step one, the alcohol content adopted by the alcohol elution is 70%.
Further, in the first step, the cooling temperature is 30-40 ℃.
Further, in the first step, the vacuum drying condition is that the temperature is 96 ℃, and the vacuum degree is 104pa。
Further, in the second step, the heating temperature is 90-95 ℃.
Further, in the second step, the temperature of the finished product is lower than 42 ℃.
Compared with the prior art, the invention has the advantages and positive effects that:
the invention adopts the biological cooperation and the coordination effect of multienzyme to repair the skin barrier and form film protection on the epidermis by adding superoxide dismutase, so that the activity of the horny layer cell is enhanced, the synthesis speed of the epidermis lipid is accelerated, the perfection of the skin barrier is improved from the inside, the skin tissue damage is repaired, and the cell regeneration is activated.
Repairing the wound surface: aiming at skin problems of plastic cosmetic surgery, laser minimally invasive surgery, dermatitis, eczema and the like, the burning pain is relieved, the erythema is eliminated, and the repair time is shortened.
Repairing the heavy sunburn: high wound healing efficiency, bacteriostasis, anti-inflammation and repair of skin tissue damage.
A novel material for promoting the rapid repair of skin surface wounds by SOD superoxide dismutase is plant macromolecule extraction.
The substance for promoting the rapid repair of the skin surface wound by the SOD superoxide dismutase is prepared by heating and mixing.
Detailed Description
For a better understanding of the present invention, the present invention is further described below in conjunction with specific embodiments.
Example 1:
the method for preparing the material for promoting the rapid repair of the skin surface wound by the SOD superoxide dismutase comprises the following steps:
the method comprises the following steps: weighing 0.1 part of polyacrylic acid, 0.5 part of triethanolamine, 2 parts of glycerol, 5 parts of SOD and 100 parts of pure water, adding water, decocting for at least 2 times, filtering, cooling to 30 ℃, mixing, filtering, eluting with 70% alcohol, collecting alcohol eluent, recovering alcohol under reduced pressure, steaming the concentrated solution at 100 ℃ in a water bath to obtain viscous gel, vacuum drying at 96 ℃ and a vacuum degree of 104pa to obtain the extract;
step two: respectively placing water and the extract in a container, heating to 90 deg.C, melting the extract, stirring and mixing at constant temperature in one direction, and cooling to below 42 deg.C to obtain the final product; as experimental group a.
Example 2:
the method for preparing the material for promoting the rapid repair of the skin surface wound by the SOD superoxide dismutase comprises the following steps:
the method comprises the following steps: weighing 0.2 part of polyacrylic acid, 1.5 parts of triethanolamine, 6 parts of glycerol, 20 parts of SOD, 2 parts of vitamin C, 20 parts of gelatin, 15 parts of sodium alginate and 200 parts of pure water, adding water, decocting for at least 2 times, filtering, cooling to 40 ℃, mixing, filtering, eluting with alcohol with the alcohol content of 70%, collecting alcohol eluent, recovering alcohol under reduced pressure, steaming the concentrated solution into viscous gel at the temperature of 100 ℃ in water bath, drying in vacuum at the temperature of 96 ℃ and the vacuum degree of 104pa to obtain the extract;
step two: and respectively placing the water and the extract in containers, heating to 95 ℃, melting the extract, continuously stirring and mixing in one direction at constant temperature, and cooling to less than 42 ℃ to obtain a finished product serving as an experimental group B.
Example 3:
the method for preparing the material for promoting the rapid repair of the skin surface wound by the SOD superoxide dismutase comprises the following steps:
the method comprises the following steps: weighing 0.15 part of polyacrylic acid, 1 part of triethanolamine, 4 parts of glycerol, 15 parts of SOD, 1 parts of vitamin C, 10 parts of gelatin, 10 parts of sodium alginate and 150 parts of pure water, adding water, decocting for at least 2 times, filtering, cooling to 35 ℃, mixing, filtering, eluting with 70% alcohol, collecting alcohol eluent, recovering alcohol under reduced pressure, steaming the concentrated solution at 100 ℃ in a water bath to obtain viscous gel, drying in vacuum at 96 ℃ and 10 degrees of vacuum4pa to obtain the extract;
step two: and respectively placing the water and the extract in containers, heating to 93 ℃, melting the extract, stirring and mixing continuously in one direction at constant temperature, and cooling to less than 42 ℃ to obtain a finished product, wherein the finished product is used as an experimental group C.
Example 4:
the method for preparing the material for promoting the rapid repair of the skin surface wound by the SOD superoxide dismutase comprises the following steps:
the method comprises the following steps: weighing 0.1 part of polyacrylic acid, 1 part of triethanolamine, 4 parts of glycerol, 10 parts of SOD, 1 parts of vitamin C, 10 parts of gelatin, 10 parts of sodium alginate and 100 parts of pure water, adding water, decocting for at least 2 times, filtering, cooling to 30 ℃, mixing, filtering, eluting with 70% alcohol, collecting alcohol eluent, recovering alcohol under reduced pressure, steaming the concentrated solution at 100 ℃ in a water bath to obtain viscous gel, vacuum drying at 96 ℃ and 10 degrees of vacuum4pa to obtain the extract;
step two: and respectively placing the water and the extract in containers, heating to 90 ℃, melting the extract, continuously stirring and mixing in one direction at a constant temperature, and cooling to less than 42 ℃ to obtain a finished product serving as an experimental group D.
Example 5:
the effect of experimental groups a-D was tested.
The method comprises the steps of adopting 5 female rabbits with the same size and weight, adopting intravenous pentobarbital sodium for anesthesia, then symmetrically cutting two round wounds with the diameter of 2cm along two sides of a spine, causing a bleeding wound, respectively applying the medical dressing and the sterilized gauze manufactured by the application to the wounds on two sides, slightly pressing for 1min, stopping bleeding after 45min, then adopting 5ml of cyanide methemoglobin reagent, cleaning the replaced dressing, and adopting the wavelength of 560nm of an ultraviolet spectrophotometer to measure the bleeding amount, wherein the results are shown in table 1.
Table 1: absorbance of luminosity
| Experimental group A | Experimental group B | Experimental group C | Experimental group D | |
| Dressing material | 0.984 | 0.761 | 0.738 | 0.784 |
| Sterilizing gauze | 1.785 | 1.852 | 1.695 | 1.732 |
As can be seen from the table 1, the skin barrier is repaired by adding superoxide dismutase and adopting the biological synergy and the synergistic interaction of multiple enzymes, so that the membrane protection is formed on the epidermal skin, the activity of the stratum corneum cells is enhanced, the synthesis speed of epidermal lipid is accelerated, the perfection of the skin barrier is improved from the inside, the skin tissue damage is repaired, and the cell regeneration is activated.
The embodiments of the present invention have been described in detail, but the description is only for the preferred embodiments of the present invention and should not be construed as limiting the scope of the present invention. All equivalent changes and modifications made within the scope of the present invention should be covered by the present patent.
Claims (10)
1. A material for promoting the rapid repair of skin surface wounds by SOD superoxide dismutase is characterized in that: the composition comprises the following components in parts by weight:
0.1-0.2 part of polyacrylic acid, 0.5-1.5 parts of triethanolamine, 2-6 parts of glycerol, 0-20 parts of SOD5, 0-2 parts of vitamin C, 0-20 parts of gelatin, 0-15 parts of sodium alginate and 100 parts of pure water.
2. The material for promoting the rapid repair of skin surface wounds by SOD superoxide dismutase as claimed in claim 1, wherein: comprises the following components in percentage by weight:
0.1 part of polyacrylic acid, 1 part of triethanolamine, 4 parts of glycerol, 10 parts of SOD, 1 parts of vitamin C, 10 parts of gelatin, 10 parts of sodium alginate and 100 parts of pure water.
3. The material for promoting the rapid repair of skin surface wounds by SOD superoxide dismutase as claimed in claim 1, wherein: comprises the following components in percentage by weight:
polyacrylic acid 0.1 part, triethanolamine 1 part, glycerin 4 parts, SOD10 parts, and pure water 100 parts.
4. The material for promoting the rapid repair of skin surface wounds by SOD superoxide dismutase as claimed in claim 2, wherein: the activity unit of the SOD is 5000U/g.
5. A method for preparing a material for promoting rapid repair of wounds on the skin surface from SOD superoxide dismutase as described in any one of claims 1 to 4, wherein: the method comprises the following steps:
the method comprises the following steps: weighing the materials according to the prescription, adding water, decocting for at least 2 times, filtering, cooling, mixing, filtering, eluting with alcohol, collecting the alcohol eluate, recovering alcohol under reduced pressure, steaming the concentrated solution into viscous gel at 100 deg.C in water bath, and vacuum drying to obtain extract;
step two: respectively placing water and the extract in a container, heating to melt the extract, stirring and mixing continuously in one direction at constant temperature, and cooling to obtain the final product.
6. The method for preparing a material for promoting rapid repair of skin surface wounds by SOD superoxide dismutase as claimed in claim 5, wherein: in the first step, the alcohol content adopted by the alcohol elution is 70%.
7. The method for preparing a material for promoting rapid repair of skin surface wounds by SOD superoxide dismutase as claimed in claim 5, wherein: in the first step, the cooling temperature is 30-40 ℃.
8. The method for preparing a material for promoting rapid repair of skin surface wounds by SOD superoxide dismutase as claimed in claim 5, wherein: in the first step, the vacuum drying condition is that the temperature is 96 ℃, and the vacuum degree is 104pa。
9. The method for preparing a material for promoting rapid repair of skin surface wounds by SOD superoxide dismutase as claimed in claim 5, wherein: in the second step, the heating temperature is 90-95 ℃.
10. The method for preparing a material for promoting rapid repair of skin surface wounds by SOD superoxide dismutase as claimed in claim 5, wherein: in the second step, the temperature of the finished product is lower than 42 ℃.
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| Application Number | Priority Date | Filing Date | Title |
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| CN202011030149.6A CN112169014A (en) | 2020-09-27 | 2020-09-27 | Material for promoting rapid repair of skin surface wound by SOD (superoxide dismutase) and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN202011030149.6A CN112169014A (en) | 2020-09-27 | 2020-09-27 | Material for promoting rapid repair of skin surface wound by SOD (superoxide dismutase) and preparation method thereof |
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| CN108619495A (en) * | 2018-04-24 | 2018-10-09 | 金寨县鑫和新能源科技有限公司 | A kind of composition of the health products of auxiliary treatment pelvic hydrops |
| CN113491663A (en) * | 2021-03-25 | 2021-10-12 | 广州真极和美生物科技有限公司 | Superoxide dismutase composition and preparation method thereof |
| CN115381735A (en) * | 2022-08-13 | 2022-11-25 | 上海纳米技术及应用国家工程研究中心有限公司 | Hydrogel dressing for skin oxidation resistance and preparation method thereof |
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| CN115381735A (en) * | 2022-08-13 | 2022-11-25 | 上海纳米技术及应用国家工程研究中心有限公司 | Hydrogel dressing for skin oxidation resistance and preparation method thereof |
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